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In 1980, His Business Became The Fastest Company In History To Reach $1 Billion In Sales. Today, His Heirs Sit On Top a $453 Billion Combined Fortune. Here’s How Sam Walton Built the Biggest Retail Empire in America’s History

Sam Walton opened a single discount store in rural Arkansas in 1962 with no obvious path to greatness. What he built in the decades that followed rewrote every assumption about how fast a retail empire could grow and how much wealth one family could accumulate.

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Sep 27 • 8:35 PM EDT • Business • finance.yahoo.com
Inside $23 billion Schonfeld's macro growth

The New York-based manager has dozens of macro investment staffers around the world now.

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Sep 14 • 5:41 AM EDT • Business • businessinsider.com
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UT Health San Antonio’s $1 billion multiyear investment helps meet demand for care

Healthcare is a strong economic driver in San Antonio, generating more than $43 billion annually and supporting nearly 200,000 jobs across the region, according to the San Antonio Chamber of Commerce. As the region's academic health center, UT Health San Antonio contributes approximately $3.2 billion annually through patient care, research, education and workforce development.

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Jul 17 • 6:02 PM EDT • Health • news.uthscsa.edu
Iran war cost $38 billion through July, report says

The U.S. is expected to spend $2 billion to $3 billion per month as the war continues, according to the Congressional Budget Office.

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Sep 15 • 3:13 PM EDT • Politics • washingtonpost.com
Bank of America Stadium renovation plans don’t include a dome. Here’s why

The newly unveiled, $1.3 billion Bank of America Stadium renovation plans didn’t include a dome. Tepper Sports’ CEO explains.

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Jul 24 • 9:00 AM EDT • Sports • charlotteobserver.com
Melco Resorts & Entertainment (MLCO) Stock Rises on Q2 2026 Earnings

Melco Resorts & Entertainment Limited (MLCO) reported second-quarter 2026 revenue of $1.3 billion, down 40.0% from a year earlier, as gross profit fell sharply to $429.4 million. Despite the weaker top line, operating profit improved to $127.8 million, while net income attributable to common shareholders rose to $22.7 million, or $0.057 per diluted share.Cash generation strengthened meaningfully during the quarter. Cash from operating activit

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Aug 13 • 10:31 AM EDT • Entertainment • quiverquant.com
What to Know Ahead of Trump’s Primetime Speech | WSJ Politics Newsletter for July 16

Plus, President Trump weighs expansion of the Iran war, and more than 100 House Democrats vote against $3 billion in military aid to Israel.

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Jul 16 • 6:45 AM EDT • Politics • wsj.com
In the decade since rate cuts began, NH business tax revenues grew by an inflation-adjusted $3 billion - THE JOSIAH BARTLETT CENTER FOR PUBLIC POLICY

In 2015, the year New Hampshire legislators began a series of business tax cuts, revenues from the state’s two primary business taxes were a combined $561.7 million. In the decade since, business tax revenues grew by more than $3 billion. From 2016-2025, the state collected $3.02 billion in new business tax revenue above the 2015 […]

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Aug 7 • 3:52 PM EDT • Business • jbartlett.org
Temple Health posted a $22.7 million operating profit in fiscal 2026

The North Philadelphia nonprofit's revenue climbed to $3.6 billion from $3.3 billion.

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Sep 29 • 11:42 AM EDT • Health • inquirer.com
Insurance Australia Group, RAC challenge $942M merger rejection

Insurance Australia Group Ltd. and RAC Insurance Pty Ltd. have lodged applications for a tribunal review of their blocked 1.3 billion Australian dollar ($942 million) takeover deal…

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Oct 9 • 10:15 AM EDT • Business • businessinsurance.com
Disney Ups Quarterly Entertainment Profit 64% to $1.68 Billion, Revenue Up 6% to $11.3 Billion

Disney Aug. 5 reported total entertainment revenue of $11.34 billion in the third quarter (ended June 27) from $10.7 billion in the previous-year quarter. Operating income skyrocketed 64% to $1.68 billion from $1.02 billion in the prior year period. Operating income growth was driven by streaming profits for Disney+ and Hulu, strong box-office returns from … Continue reading "Disney Ups Quarterly Entertainment Profit 64% to $1.68 Billion, Revenue Up 6% to $11.3 Billion"

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Aug 5 • 9:27 AM EDT • Entertainment • mediaplaynews.com
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The tariff math turns negative as refunds outpace revenue

The Trump administration’s tariff policy has resulted in substantial refunds and continued uncertainty about tariff revenue, Fortune reports. In May 2026, the Treasury refunded approximately $21.97 billion in tariffs while collecting about $21.93 billion. In June, refunds increased to $49.18 billion compared with $23.63 billion in new tariff collections, resulting in negative net customs revenue […]

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Aug 21 • 3:39 PM EDT • Business • businessreport.com
Princeton Equity Group Raises $1.3 Billion Fund III at Hard Cap

PRINCETON, N.J. & DALLAS--(BUSINESS WIRE)--Sep 29, 2026--

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Sep 29 • 8:32 AM EDT • Business • rutlandherald.com
Friant Ranch project could generate $1.3 billion in Fresno County

Friant Ranch, a proposed 2,500-home community, is projected to generate $1.3 billion in Fresno County economic activity over 10 years.

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Sep 17 • 12:17 PM EDT • Business • thebusinessjournal.com
Baidu missed revenue expectations as its ad business sank faster than AI cloud could grow

China's Baidu reported second-quarter revenue of 31.3 billion yuan, below analyst expectations, as online marketing continued to slide

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Aug 18 • 8:36 AM EDT • Business • qz.com
Reality Check: “Fifteen” attack ad on Ford raising taxes

The Better Nevada PAC’s assertion that Ford supported 15 tax hikes totaling over $3 billion is largely inaccurate. Several alleged tax increases were actually extensions of previous legislation or involved

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Sep 24 • 10:15 PM EDT • Politics • 2news.com
Democratic Senators Reintroduce the Health Infrastructure Security and Accountability Act

On September 17, 2026, two Democratic Senators reintroduced the Health Infrastructure Security and Accountability Act, which seeks to improve A pair of Democratic Senators reintroduced the Health Infrastructure Security and Accountability Act, which seeks to increase healthcare cybersecurity standards. The bill calls for $1.3 billion in government investment to help healthcare organizations adopt the essential and enhanced HHS cybersecurity goals, including $800 million for rural and underserved hospitals.

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Sep 18 • 10:34 AM EDT • Health • hipaajournal.com
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Alliance Entertainment Fiscal 2026 Revenue Rises 8% to $1.15 Billion

Alliance Entertainment (AENT) reported fiscal 2026 net revenue of $1.149 billion, up 8% from $1.063 billion in fiscal 2025. GAAP net income was $13.1 million, or $0.26 per diluted share, compared with $15.1 million, or $0.30 per diluted share, a year earlier.Gross profit rose 15% to $152.3 million and gross margin expanded 80 basis points to 13.3%. The fiscal year ended June 30, 2026.Vinyl revenue increased 13% to $383 million, while CD revenue r

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Sep 10 • 5:30 PM EDT • Entertainment • quiverquant.com
Future of Marketing Briefing: Imagining the ad business hiding inside Meta’s Muse

Meta built its $243 billion ads business on human attention. Agents could be next in line.

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Sep 25 • 12:01 AM EDT • Business • digiday.com
Science highlights six landmark DNA and Human Genome Project breakthroughs that missed the Nobel Prize

From Avery’s genetic material discovery to the Human Genome Project’s 3 billion base pairs, major life-science advances faced Nobel limits on co-authorship and timing

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Oct 5 • 11:16 AM EDT • Science • dongascience.com
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Fans, business owners react to Rays leaving St. Pete: 'A big change'

As the Tampa Bay Rays move closer to a $2.3 billion ballpark in Tampa, St. Pete businesses surrounding Tropicana Field are preparing for a new reality without the team.

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Aug 28 • 9:32 PM EDT • Business • fox13news.com
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Business interruption losses climb 30% in two years: Allianz Commercial

Rising business interruption losses are increasingly hitting companies, with fire and explosion driving the costliest claims at roughly 2.9 billion euros ($3.3 billion) as the average value of claims…

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Oct 9 • 10:15 AM EDT • Business • businessinsurance.com
Nvidia has been in talks to buy Hugging Face for more than $13 billion

Nvidia has held talks to acquire Hugging Face for more than $13 billion as the chip giant expands its AI dealmaking.

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Aug 26 • 8:34 PM EDT • Business • businessinsider.com
Site work to begin on entertainment hub, arena in Forsyth County, developer says

A $3 billion entertainment district that hopes to lure an NHL team to Forsyth County is expected to begin site work next week, according to the development team behind it.

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Sep 4 • 5:18 PM EDT • Entertainment • atlantanewsfirst.com
Singer-actor Cha Eun-woo files appeal after paying $9 mil. in taxes

Singer-actor Cha Eun-woo has filed an appeal against the National Tax Service (NTS), after paying some 13 billion won ($9 million) in additional ta...

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Aug 2 • 1:07 AM EDT • Entertainment • koreatimes.co.kr
Shopping around: How Detroit is trying to attract more retail

Detroit officials estimate residents spend over $3 billion a year in surrounding communities on goods and services they can't easily find in town.

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Sep 21 • 12:01 AM EDT • Business • detroitnews.com
How much is the NFL worth? Inside America’s most valuable sports league

Plus500 reports that the NFL is a $23 billion economy with franchises valued at an average of $7.1 billion, driven by media rights, betting, and merchandise.

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Aug 31 • 11:30 AM EDT • Sports • knsiradio.com
Visa Third-Quarter Revenue Climbs, Citing Resilient Consumer, Business Spending

The payments company said profit came in at $5.63 billion amid resilient consumer and business spending.

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Jul 28 • 4:35 PM EDT • Business • wsj.com
Bestow Launches AI-Native Lab for Innovation and Experimentation

Plus: AT&T closes on $23 billion wireless spectrum licenses acquisition, HF Sinclair plans separation of lubricants and specialties business, and more.

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Jul 31 • 10:00 AM EDT • Business • dmagazine.com
Grant Thornton to acquire CBIZ for nearly $3 billion

The all-cash, private equity-backed deal is poised to establish the largest accounting and professional services firm outside of the Big 4.

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Jul 29 • 10:30 AM EDT • Business • chicagobusiness.com
Only 46% of Gen Z, Millennial health plan members trust payers: Accenture survey

Member trust in insurers is on the decline among Gen Z and Millennials, down 10.5% between 2023 and 2026, new research from Accenture found. | This trust gap, according to analysts, could cost $3 billion in future member lifetime value for the largest commercial payers over the next decade.

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Sep 15 • 10:30 AM EDT • Health • fiercehealthcare.com
$3 billion benefits broker club: decade of dominance revealed

DOL Form 5500 data reveals a three-way race - and a lead that changed hands three times

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Sep 25 • 9:13 AM EDT • Business • insurancebusinessmag.com
Michael Dell’s son built a $13 billion home battery business—and he’s going on 30 years old

Zach Dell is banking on a home electricity and battery rental business that offers backup power without buying an exorbitantly expensive system.

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Aug 6 • 3:07 AM EDT • Business • fortune.com
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Sword Health is buying Headspace for $300 million, far below its peak value

The all-cash deal values the meditation and mental health app at roughly $300 million, well below the $3 billion valuation it reached at its peak

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Sep 16 • 1:03 PM EDT • Health • qz.com
Starbucks considers selling majority stake in its Japan business

HONG KONG >> Starbucks Corp is weighing the sale of a majority stake in its Japan business in a potential deal that could value the coffee chain’s biggest overseas company-operated market at about $3 billion, two people with knowledge of the matter said.

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Sep 16 • 8:45 AM EDT • Business • staradvertiser.com
Scientists watch a comet being born 3 billion miles away

A rare look at a centaur transforming into a comet with coma is providing a missing link in the evolution of small, icy solar system bodies.

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Sep 4 • 6:00 AM EDT • Science • space.com
Parking meter sale heads to full City Council after aldermen wring $75M from deal

A $2.53 billion transfer of Chicago’s parking meter system is poised for a final City Council vote after aldermen secured an upfront payout and a share of future profits.

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Sep 24 • 3:01 PM EDT • Business • chicagobusiness.com
PayPal becomes a takeover target as it attempts a turnaround

Stripe and Advent International reportedly offered to buy PayPal for $53 billion as the firm faces a turnaround.

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Jul 30 • 10:34 AM EDT • Business • detroitnews.com
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Michael Dell’s son built a $13 billion home battery business—and he’s going on 30 years old

Zach Dell is banking on a home electricity and battery rental business that offers backup power without buying an exorbitantly expensive system.

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Aug 6 • 3:07 AM EDT • Business • finance.yahoo.com
Comcast Business 2026 Cybersecurity Threat Report: 79.3 Billion Events Show AI Pressurizing the Threat Landscape

Comcast Business has released its 2026 Cybersecurity Threat Report, an analysis of 79.3 billion cybersecurity events detected across its cybersecurity custom...

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Oct 5 • 10:00 AM EDT • Business • businesswire.com
UK's IG Group agrees to buy sports gaming firm Underdog for up to $1.3 billion

Britain's IG Group said ​on Thursday it has ‌agreed to acquire U.S. daily fantasy sports and prediction markets ​operator Underdog for up ​to $1.3 billion, in a deal ⁠that would strengthen its ​position in the fast-growing U.S. ​retail trading market.

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Jul 30 • 12:41 PM EDT • Sports • reuters.com
Intel's PC business will be dictated by AI data center momentum: CFRA

Intel (INTC) stock is surging by over 11% in Thursday's extended hours after smashing second quarter expectations, reporting adjusted earnings of $0.42 per share (vs. estimates of $0.21) and revenue of $16.1 billion (vs. estimates of $14.43 billion). CFRA Research senior vice president and equity analyst Angelo Zino dives into Intel's earnings release and what he can garner about the trajectory of the company's PC business.

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Jul 23 • 4:46 PM EDT • Business • finance.yahoo.com
Mom-and-Pop Business Owners Grapple with Harsh Times

Report shows small business owners in NYS less optimistic about the economy. Taxes, inflation, labor costs and competition from larger businesses are major concerns right now, they say By Aaron Gifford [caption id=attachment_11067 align=alignright width=300] Ashley Ranslow is director for New York state at The National Federation of Independent Business (NFIB).[/caption] Owners of mom-and-pop businesses in New York state have been less optimistic lately than their peers in other parts of the country, a recent report indicates. The National Federation of Independent Business (NFIB), based on a survey of 11,000 of its members in the Empire State, reported that taxes, inflation, labor costs and competition from larger businesses are major concerns right now. “Indeed, while taxes are a major problem in New York and the United States overall, New York small businesses notably are struggling more with the state’s onerous, multi-level tax burden,” Ashley Ranslow, NFIB’s director for New York state, said in the July report. Compared with surveys of business owners in other states, far fewer New York respondents rated their businesses as in excellent or good health. The report also said labor costs here are about 25% higher than the national average and are the “single most important problem” facing businesses. One respondent to the New York-specific survey complained that too much red tape, taxes and laws that restrict high-yielding companies have stifled their operation’s growth. Others said high disability and workers’ compensation insurance costs, alarming increases in utility rates and excessive building regulations are discouraging. Statewide, New York has a gross domestic product of $2.53 trillion (third in the nation, followed by Texas, $2.90 trillion; and California, $4.25 trillion), a per capita income of $90,500 (sixth) and an unemployment rate of 4.6% (34th). There are 2.4 million small businesses that employ 3.9 million people. [caption id=attachment_11112 align=alignright width=451] Member of the Greater Liverpool Chamber of Commerce gather at one of the several functions the chamber organizes monthly. “Everyone in this business community encourages each other to shop local. Everyone just wants to see each other succeed,” says Megan Wilmot, the chamber director[/caption] “New York state boasts one of the largest, wealthiest and most diverse cities in the world — and that’s still only about half the state’s population,” the report said. “In other words, the state is both its iconic city and so much more — geographically, demographically, economically. But New York is not without its challenges, challenges that include notably high taxes and other weaknesses that impact the small business environment,” it said. The report includes an optimism index that compares responses from New York (NFIB) members with those of their peers in other states across several categories. This ranges from plans to increase employment to expectations for higher sales, to plans to increase inventory or expand. The scores for Empire State business owners were lower in most categories, but they did score higher than the national average in noting that they have current employment openings, and that they are hopeful that the economy will improve. “The metrics so far paint a picture of a state with a series of challenges for small businesses, from a slightly below national average Optimism Index to a more seriously below national business health to very substantially below national Employment Index. What is going on with businesses that are creating these differences?” the report stated. In Central New York, the regional labor force comprises nearly 398,000 workers. The median household income here is $71,463, and the gross domestic product for the region last year totaled $61.3 billion, according to the CenterState CEO economic development and research organization. About half of the region’s labor force works for small and mid-sized businesses, although the number of people employed in that sector has decreased by 7% since 2010, according to CenterState’s 2026 economic forecast report. “While record-high employment in large-scale enterprises provides a strong foundation for Central New York,” the report says, “the long-term health of communities depends on a thriving small business sector to serve as a stabilizer.” Area employers identify several barriers to Central New York’s anticipated growth, including lack of specialized or skilled workers, government regulations, unaffordable housing options and long-term construction disruptions. In the city of Syracuse, the number of jobs in retail trade decreased by 1,500 or 4.7% between July 2025 and this past July. By contrast, the number of jobs in the leisure and hospitality sector increased by 2.5% or 700 jobs, in the same annual period, according to the New York State Department of Labor. Still, there’s plenty of interest for new businesses across Central New York. U.S. Census figures show that the number of applications for new businesses in all four counties increased significantly in the past 20 years. In Cayuga County, there were 324 applications in 2005 compared to 470 last year. In Madison County, the number increased from 385 to 480; Onondaga County, from 2411 to 4132; and Oswego County, from 553 to 836. Downtown Cazenovia is exemplary of Madison County’s trend: In the past year, the village welcomed a bait shop, a thrift store, a vitamin infusion center, a pizzeria, a Pilates studio and an Italian restaurant. A candy store is scheduled to open on the main drag in the months ahead. Oswego’s list of interesting new businesses in the past year includes a bubble tea shop, a hot dog eatery in Fulton, a specialty grocery store that features New York state products in Mexico, a beauty and esthetics studio in Hannibal and a hardware and farm supply store in Sandy Creek. In Onondaga County, the Liverpool area has also enjoyed a steady stream of new shops and eateries in recent years. That suburban community is unique in that, unlike neighboring communities, most of the restaurants are family-owned and not part of a national chain. [caption id=attachment_11116 align=alignright width=300] Megan Wilmot is the executive director of the Greater Liverpool’s Chamber of Commerce.[/caption] Megan Wilmot, executive director of the Greater Liverpool Chamber of Commerce, said independent business owners in her community maintain a strong sense of pride in holding their own against national companies. The chamber helps boost morale with red carpet events, ribbon cuttings, coffee hours and five-year anniversary celebrations for participating businesses. “We have built such a strong community,” Wilmot said. “Everyone in this business community encourages each other to shop local. Everyone just wants to see each other succeed.” In Syracuse, the downtown retail occupancy rate last year was about 82%, a slight improvement from 2024, according to the Downtown Syracuse Committee’s most recent annual report. Buildings with the largest amount of vacant space included The Galleries, One Park Place, and Equitable Towers, though not all of those spaces are designated for retail use. New businesses that opened in downtown Syracuse last year: Better with Time Clothing, Dakshin Curry & Biriyani, Havana Tattoo Society, Milano Bean Café, Miss Daisy, Pausa Coffee, Sweets for Babe, The Society CNY and Yafah Beauty Studio. The Destiny USA mall’s occupancy rate decreased from 80% in 2023 to 72% by the end of 2024, according to Integra Realty Resources. That leaves more than a quarter of the mall’s retail space vacant. “Looking ahead, the retail market is expected to see minimal rent growth, with vacancy rates likely remaining stable in community and neighborhood centers but continuing to rise in enclosed malls,” Integra’s report said. “New construction activity is low and redevelopment plans for former malls like Shoppingtown and Great Northern are still in the planning stages. The proposed Micron chip plant may spur development, but challenges remain in finding co-developers for large-scale projects.” Nationally, the U.S. Chamber of Commerce expects that small businesses will remain resilient and see their sales and revenues eventually improve. That organization, in a recent national survey, found that 25% of small business owners expect the economy to improve in 2027, while 45% indicated that they plan to increase employment in the next 12 months. And 69% said they believe their small business is in good shape and 70% said they are comfortable with their current cash flow. Thirty-one percent of small businesses reported raising their prices in July and 28% are planning to raise their prices within the next three to four months, the report said. Twelve percent indicated that this is a good time to expand their business. “Small business owners voice optimism for future revenues and hiring,” the report said. “High costs continue to be a wet blanket on reinvestment.” The NFIB reported in July that Main Street, despite gas price hikes, “is OK … for now.” Its small business economics trend report said sales across the country have been strong compared to last year, but continued inflation and higher prices from mom-and-pop establishments are causing some “cracks” to show. “If costs stay this high for much longer, reduced investment will have a tangible economic impact,” the report said. “The status quo is OK, but the outlook? The outlook is uncertain.”

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Oct 14 • 8:23 AM EDT • Business • oswegocountybusiness.com
$75 million deal clears path for parking meter transfer vote today

Chicago aldermen are set to vote on the $2.53 billion parking meter transfer after securing a $75 million payment and a share of future revenue.

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Sep 24 • 7:00 AM EDT • Business • chicagobusiness.com
Entertainment Agency Rep, Journalists in 3 Billion Won Stock Probe

Entertainment Agency Rep, Journalists in 3 Billion Won Stock Probe Authorities probe front-running scheme, 300 stocks, 3 billion won illicit gains

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Sep 9 • 3:20 AM EDT • Entertainment • chosun.com
Another record breaker for business expansions and job growth in Georgia

Gov. Brian Kemp and the state Department of Economic Development announced $35.2 billion in project investments for the fiscal year that ended June 30. That is up from $26.3 billion the prior fiscal year, which had also broken records.

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Sep 4 • 7:40 PM EDT • Business • wabe.org
Tyson cuts profit outlook as beef business struggles

The country’s largest meatpacker now sees annual adjusted operating income of $2.1 billion to $2.3 billion for fiscal year 2026, lowering its range by $100 million.

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Aug 3 • 8:50 AM EDT • Business • ttnews.com
Shift4 Payments (FOUR): A Stock Priced for Trouble, a Business Still Compounding Underneath

Back in August, Shift4 Payments, Inc. (NYSE:FOUR) lowered its full-year outlook, cutting expected gross revenue less network fees to $2.48 billion – $2.53 billion from $2.5 billion – $2.6 billion and adjusted earnings per share to $5.15 – $5.35 from $5.50 – $5.70, citing roughly $25 million from Middle East travel disruption and $20 million […]

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Sep 27 • 7:11 PM EDT • Business • finance.yahoo.com
7 US multimillionaire donors gave $189 million to universities in 2026, far more than Africa’s 23 billionaires publicly gave to science and research

Africa’s universities and research institutions continue to operate with far less funding than those in developed economies, even as several of the continent’s richest individuals have added billions of dollars to their fortunes in 2026

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Oct 8 • 7:45 AM EDT • Science • africa.businessinsider.com
Starbucks considers selling majority stake in its Japan business, sources say

Starbucks Corp is weighing the sale ​of a majority stake in its Japan business in a potential deal that could value the coffee chain's biggest overseas company-operated ‌market at about $3 billion, two people with knowledge of the matter said.

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Sep 16 • 5:24 AM EDT • Business • reuters.com
AbCellera women’s health data top ‘most aggressive upside scenario,’ putting Astellas and Bayer on notice

AbCellera has reported phase 2 results “beyond even the most aggressive upside scenario” that its CEO dared to consider, boosting the biotech’s chances of challenging Astellas and Bayer for a women’s health market. The phase 2 clinical trial compared ABCL635, an antibody targeting NK3R, to placebo in patients with hot flashes caused by menopause. Investigators enrolled 92 postmenopausal women experiencing a mean of about 10 moderate or severe hot flashes per day. By Week 4, the number of moderate or severe hot flashes had fallen by a mean of 8.8 on ABCL635 and by 3.5 on placebo. That statistically significant, placebo-adjusted reduction of 5.3 hit the trial’s primary endpoint. The level of efficacy also cleared the bar set by existing drugs. While cross-trial comparisons can be misleading, AbCellera CEO Carl Hansen, Ph.D., had seen enough to start hyping the program. “We now view ABCL635 as a potential best-in-class non-hormonal therapy with strong differentiation against approved NK3R competitors across all important dimensions, including efficacy, safety, dosing and convenience,” Hansen said on a Monday morning conference call with investors to discuss the data. “We believe ABCL635 is now a highly de-risked program.” Last week, Hansen used AbCellera’s earnings call to set expectations for readout, with the CEO defining success as a clean safety profile and efficacy comparable to the two approved small molecules. The data vaulted over that bar. Astellas linked (PDF) one of the small molecules, Veozah, to placebo-adjusted reductions in hot flash frequency of 2.1 and 2.6 at Week 4 of its two phase 3 trials. Bayer reported (PDF) placebo-adjusted reductions of 3.04 and 3.29 at Week 4 of pivotal studies for its small molecule, Lynkuet. At 5.3, the placebo-adjusted reduction in AbCellera’s trial comfortably cleared the standard set by the incumbents. Veozah and Lynkuet came to market based on evidence of their ability to reduce the frequency and severity of hot flashes. AbCellera’s phase 2 study covered both endpoints, with the Canadian biotech reporting a mean reduction in severity of 1.4 points at Week 4 on ABCL635, compared to 0.3 points for placebo. Again, the placebo-adjusted result compares favorably to data on Veozah and Lynkuet. Analysts shared Hansen’s enthusiasm for the data. The phase 2 results “firmly validate ABCL635 as a potentially best-in-class treatment,” BMO Capital Markets analysts said in a note to investors Monday. ABCL635’s apparent efficacy edge “is likely attributable to the higher dosing/target engagement the asset is able to reach vs. the oral agents due to its wider therapeutic index,” the analysts added. The analysts, who model $2.3 billion in unadjusted peak sales for ABCL635, flagged the safety profile as another positive of the phase 2 readout. While Veozah carries a boxed warning for liver damage, nobody on ABCL635 in the phase 2 trial had elevated liver enzymes or bilirubin values. If replicated in phase 3, the lack of a liver signal could allow approval without the monitoring requirements imposed on Veozah. Investors appeared equally enthused, sending AbCellera's stock up 32% to $9.21 in premarket trading Monday from a Friday closing price of $6.93. Next, AbCellera will collect the Week 12 data and talk to its advisors about further development. The results open up “a wide variety of possibilities of how we might take this forward into phase 3 studies to truly maximize the value of the asset and make sure that ABCL635 is able to demonstrate its differentiation potential,” Sarah Noonberg, M.D., Ph.D., AbCellera’s chief medical officer, told investors.

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Aug 10 • 8:24 AM EDT • Health • fiercebiotech.com
Johnson & Johnson is in talks to sell its orthopedics business to Apollo for $20 billion

Apollo is in discussions to acquire DePuy Synthes, which generated $9.3 billion in sales last year and could also be spun off as a public company

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Sep 14 • 9:53 AM EDT • Business • qz.com
BUSINESS UPDATE: All About Cannabis

SUNY Oswego’s cannabis studies prepares for growing business opportunities By Mary Beth Roach [caption id=attachment_11114 align=alignright width=383] Marthinus (Martin) Koen is associate professor of criminal justice and cannabis studies at SUNY Oswego. He and the chair of the SUNY Oswego’s Criminal Justice Department, Roger Guy, created the program.[/caption] As the cannabis industry in New York state continues to grow, so do the business opportunities. New York’s legal cannabis market is projected to hit $3 billion in annual sales this year and more than 600 licensed dispensaries are operating across the state, according to budpedia.com. It’s estimated that New York will add about 16,160 new cannabis jobs in 2026, according to the 2026 U.S. Cannabis Jobs Report. SUNY Oswego, realizing the potential, now offers two programs to acquaint both matriculated and non matriculated students with aspects of this multi-billion-dollar business. Its cannabis studies microcredential came out last year and a minor was introduced this fall. The microcredential allows traditional students to add electives to their degree. Students who are not enrolled in the college can sign up to take classes to learn more about the field, growing the crop and managing or opening a dispensary, according to Marthinus (Martin) Koen, associate professor of criminal justice and cannabis studies at SUNY Oswego. The classes are designed to give those who wish to pursue business opportunities in the field a much broader understanding of cannabis and a more overall perspective of the various aspects of running a business, such as supply chain management, customer service and best practices. “When you’re trying to market it, when you’re trying to make sales, you’re understanding will be a lot more vast and nuanced,” he said. “The last 10 years especially, the hard science on cannabis increased and we have a lot more nuanced understanding right now that hasn’t yet permeated the pop culture,” he added. Koen’s team is also hoping to develop an independent study class that will help somebody who wants to apply for a license. That the classes fill up quickly should come as no surprise. “I think there’s a lot of people who are excited about it because it’s a new industry,” he said and they see an opportunity to make some money. Matriculated students may look at it as fun to learn about and stack on top of their existing major or minor. According to the college’s website, students interested in a microcredential would take cannabis law and policy and cultivation of cannabis, along with two other electives. For the first elective they could select either the economics of cannabis or manufacturing, distribution, and logistics of cannabis; and the second elective would be either cannabis science, analysis, and well-being or cannabis and society. The idea for a microcredential in cannabis studies at SUNY Oswego began in 2023, Koen said, as SUNY statewide was advocating for these types of initiatives. Koen and the chair of the SUNY Oswego’s Criminal Justice Department, Roger Guy, began brainstorming on ideas. Catching their attention was the legalization of full recreational marijuana use in New York state in 2021 and the problem-riddled rollout of the state’s Office of Cannabis Management. Guy and Koen created a Criminal Justice Elective called CRJ 420, called cannabis and society, to see if there was any interest. It shouldn’t surprise anyone that there was interest —a lot of it. Further discussions led to the microcredential, cannabis studies, which incorporated science, business and anthropological perspectives, Koen said. They were allowed to create their own prefixes for the classes, such as CAN 310; CAN 320; and CAN 420. Yes, the 420 was intentional — it’s a slang term and symbol used to refer to cannabis consumption and counterculture — but it’s also meant to reflect that the course, being on the 400 level, is “very academically involved,” Koen explained. The term 420 was coined in 1971 by a group of California high school students as a secret code to meet at 4:20 p.m. at a campus landmark to search for an abandoned cannabis crop nearby. The phrase has evolved, to say the least. It is now associated with cannabis use worldwide. For more information, visit ww1.oswego.edu/academics/microcredentials/cannabis-studies.

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Oct 14 • 8:23 AM EDT • Business • oswegocountybusiness.com
More than half of Premier League clubs break transfer records

More than half of the Premier League's clubs have broken their transfer records in a summer window featuring four of the top flight's five most expensive ever deals. After England internationals Elliot Anderson and Morgan Rogers joined Manchester City for £116 million ($157 million) and Chelsea for £117 million respectively, the final two days of the window brought an even bigger pair of deals as summer spending pushed beyond last season's record of £3 billion, with the final figure yet to be co

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Sep 2 • 12:33 AM EDT • Sports • sports.yahoo.com
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Nvidia in talks to acquire Hugging Face in $13 billion deal, Business Insider reports

Nvidia has been ​in serious ‌talks to acquire AI ​platform ​Hugging Face in a ⁠deal ​that would ​value the company at more ​than $13 billion, ​Business Insider reported ‌on ⁠Wednesday, citing a person familiar ​with ​the ⁠matter.

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Aug 26 • 8:45 PM EDT • Business • reuters.com
Novant Health drives $4.33B in regional economic impact, study says

Novant Health Coastal Region generates an annual overall economic impact of $4.33 billion in the Wilmington Metropolitan Statistical Area (MSA), according to a new report. Commissioned by Novant Health and conducted by Mouhcine Guettabi, associate professor of economics at the University of North Carolina Wilmington and the area’s regional economist, the report evaluates population growth in New Hanover, Brunswick and Pender counties and whether the area’s healthcare infrastructure is positioned to meet the region’s demand. According to the study, while healthcare employment has kept pace with population growth in New Hanover and Pender counties, it has not kept up with the rapid population growth in Brunswick County, which is skewed toward an older population. “It points very clearly to Brunswick County being the bottleneck, or being the place where investment is most needed,” Guettabi said to the Business Journal Friday, “because the growth is the fastest, the composition of the growth is older (adults) and demand for healthcare is much higher for the subpopulation.” The Novant Health Coastal Region employs 8,295 full-time equivalent workers, according to the report, and is the region’s largest employer. Overall, through direct, indirect and induced impacts, the Novant Health Coastal Region supports 19,573 jobs, the report said. Using data collected from internal payroll, financial and capital reports, the report estimates that Novant Health Coastal Region pays approximately $1.15 billion in total compensation to its employees. According to the study, the provider’s annual operating expenditures, or direct economic impact, total $2.36 billion. That direct impact ripples through the regional economy through spending at its suppliers, or indirect impact, and household spending by staff and its suppliers’ workers, or induced impact. The report estimates the Novant Health Coastal Region’s indirect economic impact is $786 million, reflecting the multiplying effect of the provider’s operating expenses on expenditures like medical supplies, facilities, food, IT and professional services. Because 86.9% of Novant Health Coastal Region employees live within the tri-county region, the report estimates that wages paid by Novant circulate into the regional economy, creating an induced economic impact of $1.17 billion. “That money just doesn’t go into thin air,” Guettabi said of the wages paid to Novant Health Coastal Region employees. “Some of that money is being re-spent, and therefore it’s supporting grocery stores, hiring, restaurants and bars, and there are a lot of other companies or organizations whose employment, whose activity partially depends on that.” The combination of direct ($2.36 billion), indirect ($786 million), and induced ($1.17 billion) impacts totals an estimated $4.33 billion, according to the report. A study commissioned by Novant Health in 2024 and conducted by FTI Consulting’s Center for Healthcare Economics and Policy found that Novant Health generated nearly $2 billion of direct impact, with $628 million in indirect impact and $857 million in induced impact. Healthcare investments in the pipeline for Brunswick County Additionally, the study found that while healthcare employment has kept pace with population growth in New Hanover and Pender counties, it lags in Brunswick County. “Once you go below the metro level and you decompose the three counties that make up the Wilmington Metro,” Guettabi said, “it becomes fairly clear that Brunswick is the standout. And not only that, but clearly the growth there is fully domestic migration and largely retiree-driven migrants.” Using data from the Centers for Medicare and Medicaid Services on per-capita healthcare spending among age groups, Guettabi estimates that adults aged 65 and older demand 2.44 times the healthcare of working-age adults. “The share of the population in Brunswick County that’s over the age of 65 is 33%,” Guettabi said, “which is so much higher than the average share of people over the age of 65 within the state or within the country.” The report emphasizes that Brunswick County is the “strongest candidate” for new healthcare investment, adding that patient discharge records show Brunswick residents rely heavily on facilities in New Hanover County for inpatient care. “Investments in Brunswick County would not only meet the demand for those residents, but it would also relieve pressure for New Hanover County residents,” Guettabi said. Laurie Whalin, president of the Novant Health Coastal Region, told the Business Journal Friday that the provider plans to expand services at Novant Health Brunswick Medical Center, in addition to other investments in the area. In April, the state granted conditional approval to both Novant Health and Columbus Regional Healthcare System to build new hospitals, just miles apart, on either side of the Columbus County and Brunswick County borders. Columbus Regional’s $214 million 30-bed hospital would be located at the former Acme-Delco Middle School in Delco, according to the application. The project’s approved timetable has construction slated to finish in May 2029, with the hospital open for service by October 2029. The Whiteville-based provider, which Atrium Health manages, broke ground on an Advanced Care facility in December 2025 and operates four specialty clinics in Leland. Meanwhile, Novant Health’s proposed $251 million 20-bed hospital would be built just miles from Columbus Regional’s proposed hospital, near the Compass Pointe community in Leland. The provider estimates the hospital will open by 2030. State officials also approved Novant Health in March to build a freestanding emergency department in Carolina Shores, near U.S. 17. The project is estimated to cost $24 million, according to the application, and will operate under the Novant Health Brunswick Medical Center license. Additionally, Novant Health’s 16,000-square-foot ambulatory surgery center is slated to open in Leland by year’s end, officials said.

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Sep 18 • 2:16 PM EDT • Health • wilmingtonbiz.com
Cloud AI Today - Cloud Gaming Thrives as 5G Fuels Traveler Entertainment

The cloud gaming sector is poised for substantial growth, particularly within the traveler segment, as advancements in 5G technology, edge computing, and increased travel fuel demand for entertainment on the go. Projections indicate the market will grow from $3.2 billion in 2025 to $4.1 billion in 2026, with expectations to reach $11.03 billion by 2030. This expansion is driven by factors such as enhanced mobile connectivity, widespread adoption of portable gaming devices, and rising interest...

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Aug 28 • 8:08 AM EDT • Entertainment • simplywall.st
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Scientists Pinpoint a Possible “Sweet Spot” for Life’s Origins 4.33 Billion Years Ago

By simulating a billion years of Earth’s history, researchers have identified a possible window for life’s earliest chemistry around 4.33 billion years ago. During its first few hundred million years, Earth was a hostile target. Asteroids, comets, and leftover planetesimals, smaller bodies remaining from planet formation, relentlessly battered the planet, generating intense heat that could

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Sep 28 • 9:38 AM EDT • Science • scitechdaily.com
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Trane inks business, marketing partnership with Bank of America Stadium

Trane Technologies is deepening its ties to Bank of America Stadium as a cornerstone partner that will lead HVAC upgrades as part of the $1.3 billion upgrade of the downtown Charlotte venue. The agreement will put Trane’s name on the stadium’s 300-level Silver Club section, starting in 2029, Tepper Sports & Entertainment said in a […]

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Sep 29 • 1:13 PM EDT • Business • businessnc.com
Grant Thornton to acquire CBIZ for nearly $3 billion

The combination would establish the fifth-largest accounting firm in the U.S.

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Jul 29 • 9:58 AM EDT • Business • crainscleveland.com
Sports without politics is a fantasy and the World Cup proves it

From ancient Greece to Nazi Germany, sport and politics have long been intertwined. Nevertheless, we still imagine that international sport can be kept above the fray and serve as a neutral arena where nations compete on merit alone. In this article, diplomacy scholar Geoffrey Allen Pigman argues the 2026 FIFA World Cup shows this is a dangerous illusion. When international sport is left entirely to revenue-maximizing private bodies like FIFA, it doesn't escape politics, but rather surrenders to its worst expressions. With the 2028 Los Angeles Olympics fast approaching, the IOC must decide whether to learn that lesson or repeat the same mistakes. The largest and most lucrative FIFA World Cup ever draws toward its climactic conclusion amidst a swirl of controversy. Team members, staff, fans, and spectators have been denied their right to enter the United States to participate, and US President Donald Trump intervened with FIFA boss Gianni Infantino to overturn a referee’s call that Trump believed disadvantaged the US national team. It is a moment to step back and reflect on what the purposes of international sport mega-events like the World Cup, and international sport more broadly, are, and what they should be. Does international sport serve public purposes? Is there a public interest? Or is it primarily a private endeavor organized by commercial enterprises to entertain the global public (and generate profit in the process), which is occasionally used by governments and leaders for raisons d’etat? Central to the idea of sport is the principle of fair play, which in the international context demands that games be free from political interference. However, it is impossible to separate sport from politics, all claims to the contrary notwithstanding. The most positive political use of international sport through the millennia has been to facilitate diplomacy. The use of international sport for diplomatic objectives has existed since at least the time of the ancient Olympic Games, around which was instituted the custom of the Ekecheiria, or Olympic Truce, between participating states to facilitate fair competition and diplomatic achievements by ensuring that participants could travel safely to the Olympiad. In his seminal work On Diplomacy (1987), diplomacy scholar James Der Derian characterized the objectives of diplomacy as overcoming alienation and mediating estrangement between governments and between peoples. One increasingly important diplomatic tool in the technology-infused media environment over the past century has been public diplomacy, under which governments and non-state diplomatic actors (e.g. transnational corporations) communicate to global publics about their international policy objectives and to shape their global brand image. Political scientist Michał Kobierecki, in his important book Sports Diplomacy (2020), views sports diplomacy as falling broadly within the ambit of public diplomacy, as international sport intimately involves the participation of global publics as spectators and consumers of global media. Diplomacy scholar Stuart Murray and this author, in a 2013 article, distinguish between international sport used for diplomatic purposes and international sport-as-diplomacy, which encompasses the range of diplomacy that occurs as teams and competitors, spectators and fans, and government officials all converge for international sporting events like the Olympic Games and FIFA World Cup. Diplomacy scholar H.E. Chehabi, in a 2001 article on US-Iran sports diplomacy, describes the interaction between spectators and fans at international sporting events as “people-to-people diplomacy,” in which relationships develop independently of governments and their objectives. Diplomacy by the aforementioned definitions is often unsuccessful. Moreover, all too often the tools of diplomacy may be employed by governments and other actors to thwart or oppose the objectives of diplomacy as characterized by Der Derian. Governments routinely use the tools of public diplomacy to disseminate propaganda, spreading misinformation in the attempt to deceive global publics about their objectives and to create misleading impressions about their brand identity. Within sports diplomacy, the term “sportswashing” has been coined recently to describe how governments invest in and promote international sport to create positive global public impressions of their nations and, in doing so, to distract the global public from their deficient records in areas such as human rights and democratic governance. Murray, in his 2018 book Sports Diplomacy: Origins, Theory and Practice, introduces the concept of sports anti-diplomacy, wherein governments intentionally use international sport to advance aggressive and nationalistic objectives. Obvious historical examples include Hitler’s use of the 1936 Berlin Olympics to glorify his Third Reich and the 1969 El Salvador-Honduras football “war.” SUGGESTED READING The beautiful game made ugly By Emily Ryall FIFA argues that it is and seeks to be apolitical in its stewardship of international Association Football (soccer). FIFA policies governing bids to host the World Cup require uninhibited and non-discriminatory access for players, team staff, and spectators of all participating countries to host nations and venues. It became clear soon after Trump returned to power in the United States in January 2025 that Trump’s political intentions and objectives to limit non-US citizens from living and working in the United States and, in numerous cases, even visiting the country, would collide with FIFA’s host nation policies. Beginning soon after the start of the second Trump administration, US federal authorities imposed restrictions on entry to the United States of citizens of between 20 and 40 countries for any purpose, with only limited exceptions. Federal Immigration and Customs Enforcement (ICE) began arresting non-US citizens in the United States, including persons with and without legal status, holding them in jails, concentration camps, and other detention facilities until they were deported to their home or third countries, where they faced substantive risks to their personal safety. FIFA boss Gianni Infantino, in an effort to ensure the most successful and lucrative World Cup in history, engaged diplomatically with President Trump in an attempt to facilitate entry to the US for World Cup participants. Infantino did all in his power to ingratiate himself with Trump, to the extent of creating a FIFA “Peace Prize,” which he awarded to Trump in December 2025 at a ceremony in the then Trump-controlled John F. Kennedy Center for the Performing Arts in Washington, DC, on the occasion of the World Cup draw. The prize was an ersatz consolation for someone who aspired in vain to win the rather more prestigious and well-known Nobel Peace Prize. And in the run-up to the World Cup, conditions became worse. In February 2026, Trump and Israeli Prime Minister Benjamin Netanyahu launched a war of aggression against Iran, illegal under international law, under the false pretence that Iran’s government was preparing to attack the United States and Israel. During the US aerial bombardment of Iran, US planes bombed Azadi Stadium, the facility where Iran’s national football team trained. As the 2026 FIFA World Cup began, it was clear that Infantino’s efforts had been for naught: the Trump administration would not adhere to FIFA policies governing access to World Cup host nations. World Cup referee Omar Artan, a citizen of Somalia, was denied a US visa to enter the United States to participate in the World Cup. Trump’s government only granted US visas to Iran’s football team ten days before they were scheduled to arrive for the tournament. Numerous members of the support staff for Iran’s team were denied US visas. Iran’s team, which had been scheduled to train in Arizona, was directed to shift its training site to Tijuana, Mexico, notwithstanding that all three of their group stage matches took place at US venues. The US Department of Homeland Security only permitted the Iranian team to enter the US on the day before each scheduled match and then to return to Mexico immediately after playing. Members of Iraq’s and Switzerland’s football teams were delayed for hours by US officials at the US border, and an Iraqi team photographer was refused entry. Spectators and fans from Haïti and Iran were denied entry to the United States altogether. A large number of fans from a range of countries had their applications for US visas rejected. There were multiple off-ramps through which participants could have avoided the negative consequences of Trump’s decisions for the 2026 World Cup. Once it was clear that the Trump government intended to violate the established expectations for World Cup hosts, FIFA could have shifted the matches scheduled to take place in the United States to Mexico and Canada. The three nations were already designated as co-hosts, and host cities and venues had been selected. Once it was clear that FIFA, governed by FIFA boss Gianni Infantino’s dependent and dysfunctional relationship with Trump, would never consider this option on its own, it fell to the national football federations to act. The national federations, particularly some combination of federations of the leading contenders (France, Spain, Brazil, Argentina, Morocco, England, Germany, etc.), could have refused to participate under the US-imposed conditions or, at the least, demanded an ironclad agreement with the Trump government that FIFA policies on access would be respected. ___ International sport is inextricably entangled with diplomacy of different sorts, for good or ill, it cannot be considered to be in the purely private realm and left to revenue-maximizing private actors. ___ Why did neither FIFA nor the national football federations act to protect the interests of players, team staff, referees, fans, and spectators? In essence, the relentless engines of capitalism prevailed over norm observance, ethics, and fair play. The revenue interests of FIFA, sponsors, global media, and host cities won out. FIFA’s managers viewed hosting another World Cup principally in the United States as a veritable pot of gold for FIFA and its collaborators. FIFA has estimated its own revenue over the 2023-26 budget cycle, which includes the 2026 World Cup, at $13 billion, revised up from an initial projection of $11 billion, and 72% higher than the previous revenue cycle. Of that total, FIFA is estimated to have generated $8.9 billion from the Cup itself in revenue from TV rights ($3.92 billion), sponsorships ($2.69 billion), ticket sales ($3.1 billion), licensing rights, and other sources. A joint study by FIFA and the World Trade Organization estimates that the World Cup will contribute over $40 billion to global GDP, including nearly $14 billion in direct visitor spending in the three host countries (but principally in the United States, which hosted the lion’s share of the matches). The FIFA World Cup is now reportedly “the single most lucrative recurring commercial property in global sport.” And yet, notwithstanding the Trump government’s uses of the World Cup for sports anti-diplomacy, and the climate of anxiety that this created for participants and spectators, diplomacy that did not depend upon governments was able to thrive at the World Cup. Examples of successful people-to-people diplomacy were legion, as citizens of towns and cities across the States, as well as in Mexico and Canada, welcomed team members, their families and supporters, to training sites across North America. Fans of different teams joined together in person in stadiums for matches, at watch parties and bars, and at welcome events sponsored by host cities. The joy and camaraderie shared between the citizenry of Boston and Scotland’s “Tartan Army” of fans is but one example of how the “Beautiful Game” brings people together. Friendships forged across continents are likely to endure well beyond the Cup final. Even those achievements cannot be seen as unalloyed, however. As South African football fan Byron Pillay commented to Al Jazeera, “Football is called the Beautiful Game for a reason, for its ability to unite people. But it’s hard to believe in that magic with the politics and war rhetoric off the field of play, especially when one of the tournament hosts is central to that.” Ultimately, the experience of the 2026 FIFA World Cup illustrates that, as international sport is inextricably entangled with diplomacy of different sorts, for good or ill, it cannot be considered to be in the purely private realm and left to revenue-maximizing private actors. As long as there is the possibility of diplomatic progress in mediating estrangement between governments or between peoples, there is a broad and overarching public interest in international sport. Likewise, as it would be difficult to put on an international sport mega-event without international sporting organizations like FIFA and the International Olympic Committee (IOC), global media firms, and companies purchasing sponsorships, public and private interests in international sport must coexist, most likely somewhere on a shifting spectrum between partnership and rivalry or cross purposes. As the World Cup wraps up, the IOC needs to consider its lessons before the scheduled 2028 Los Angeles Olympics if they want to avoid a media-hyped Trump version of the 1936 Berlin Olympiad. The IOC and the National Olympic Committees need to set conditions on and make demands of Trump’s government with clearly articulated consequences for non-compliance, up to and including cancellation of the Games. Time is running out for the IOC, as unlike with the FIFA World Cup, there is no at-the-ready alternate venue for Los Angeles.

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Jul 16 • 8:00 PM EDT • Politics • iai.tv
Scientists watch a comet being born 3 billion miles away

A rare look at a centaur transforming into a comet with coma is providing a missing link in the evolution of small, icy solar system bodies.

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Sep 4 • 6:00 AM EDT • Science • yahoo.com
Chartbook 464 The"China squeeze" - the politics of development counterfactuals.

There are three types of China shock discourse. Each has a distinct temporal register. China shock 1.0 was a phrase coined by US academics in the 2010s to retrospectively summarize the impact on particular US labour markets, which they identified through painstaking empirical investigation. China shock 2.0 on everyone’s lips in Europe in the mid 2020s is an alarm raised by trans-Atlantic policy thinkers warning of a coming disaster which they project onto Europe’s ailing car industry. The third type of China shock discourse - commonly known as the “China squeeze” launched most recently by Indian economists Shoumitro Chatterjee and Arvind Subramanian in the pages of Foreign Affairs - mobilizes a different, more speculative temporal register: the counterfactual realm of alternate history. The China squeeze argument asks not what has happened, or what is going to happen, but what might have been. Specifically, what options for economic development might have been open to Global South economies like India or the economies of sub-Saharan Africa, had it not been for China’s spectacular industrialization since the late 1990s and the persistent competitiveness of China’s manufacture in low-skilled segments. Chatterjee and Subramanian’s argument is that whilst China has built a powerful position in electrical machinery and other high-skill manufacturing, which is now delivering China Shock 2.0, it also continues to run a trade surplus in low-skill, labour-intensive manufacturing. This surplus is large and has remained largely unchanged in fifteen years. Indeed, in the 2010s, in trade with low-income countries, China’s surplus rapidly increased. On their reading, this squeezes low-income producers in low-skill sectors in which they “should” be able to compete. Source: “China’s Mercantilist Squeeze on Developing Countries” Shoumitro Chatterjee and Arvind Subramanian. Peterson Institute for International Economics 26-7 May 2026 Chatterjee and Subramanian’s wording is telling: (emphasis mine) The canonical trajectory of economic development in the post-World War II period is for countries to transition from agriculture to manufacturing, first in low-skilled manufacturing and then later on to high-skill manufacturing (Herrendorf, Rogerson, and Valentinyi 2013). At the global level, this implies that high-income countries (HICs) that once specialized in low-skilled activities cede manufacturing export space to poorer countries that come along to occupy that space. In 1965, advanced economies accounted for about 60 percent of global value-added exports in four key low-skilled manufacturing sectors, i.e., apparel, leather, textiles, and footwear. Over time this share declined and began to be occupied first by the East Asian tigers and, beginning in the late 1990s, by China. Today China accounts for about 50 percent of the global market. The question is whether China, with its rising prosperity, is continuing to behave like its richer counterparts and ceding export space to poorer followers or to behave unlike them and continuing to occupy space. In terms of the conceptual maneuvers it performs, of the three China shock discourses, the “China squeeze” argument is by far the most ambitious. After all, it bases its critique of China on a counterfactual imagining of the world. Like any counterfactual argument, to construct this alternative reality it must rely on a heuristic model. To make their argument Chatterjee and Subramanian mobilize two key claims. The first reference point is the actual history of rich-country industrialization, what they refer to as the “canonical path”. The idea is that countries transition from agriculture to light industry and low-skilled manufacturing and from there up the value chain. To make this useful as a standard of comparison and a means to construct a normative standard, they adjust sectoral export shares for two factors: 1. the underlying level of economic development of the exporting country, as measured by national income and 2. the degree to which the sector in question is internationalized. The idea being that for a high income country to have a high export share in low-skill sectors is anomalous and even more so if that particular product is highly internationalized and thus suitable for being “conceded” to lower-income competitors. Where should this process end? Here Chatterjee and Subramanian introduce their second benchmark. Their normative idea of a global development path is one in which, in due course, low-skill manufacturing exports are distributed in proportion to a country’s share in the global labour force. They imagine, in other words, a world of proportional, polycentric global development without much national specialization in low-skill manufacturing. A useful benchmark is that, in labor-intensive manufacturing sectors, a country’s share of world exports should be broadly commensurate with its share of the world’s low-skilled labor endowment. … In the Heckscher-Ohlin model, this would be true if value added per worker and export propensities, i.e., fraction of output that is exported, are the same across countries. It is this pleasant liberal vista of orderly global development, progressing towards a general distribution of low-skilled manufacturing against which they judge reality and conclude that the low-income countries are suffering a “China squeeze”. China is not exiting low-skill sectors fast enough Allowing for its gdp level and the degree of globalization, China’s share of low-skill manufacturing exports is far higher than it “should” be. Relative to population, its low-skill share of exports is far too high. That in turn yields the conclusion that huge numbers of jobs - the authors suggest tens of millions - are being hoarded by China. For the four sectors captured in figure 4, this excess in value-added exports is $110 billion in 2022. For all low-skilled sectors overall captured in appendix figure D.1, excess value-added exports amount to $365 billion. The crowding out of LMIC exports by China is therefore substantial. Both these claims have in common that they are strong structuralisms. The first is that development paths ought to resemble each other. The second is that broadly speaking as far as low-skilled manufacturing is concerned, all countries are alike. If the world currently diverges from the distribution of trade implied by these assumptions, if China is not following the advanced economy path and has huge exports, this must be the result of “policy”, which the authors then put in question as illegitimate or unfair. Thus the naturalistic construction of a canonical path leading to a “level” distribution of low-skilled manufacturing reveals itself to be a polemical tool. From the point of view of China shock polemics, this discourse is no doubt welcome. But as an account of economic history, it must surely be regarded as nothing short of bamboozling. Development paths do not follow a regular, natural sequence. As David Fishman put it aptly, “development is not a queue”. They are always and everywhere, through and through political. Development is not so much a process, as a project. Each such project is more or less well adjusted to its context. As Gerschenkron taught uneven and combined development implies differentiation rather than simple imitation on a single parth. It may be true that Europe and the US exited relatively early from low-skill work. But clearly technology has changed. As C&S themselves point out, China no longer enjoys a low wage environment. Do they really believe that such huge differences can be accounted for either by industrial policy, which as they admit does not operate powerfully in low-skill sectors, or by exchange rate manipulation? What is overwhelmingly dominant in explaining the persistence of “low-skill” manufacturing in China are surely the network effects of complex supply chains. Indeed the label of “low-skill” may miss the point. The degree of globalization which Chatterjee and Subramanian decide to conjure away in their model of the development path - to allow for the fact that Europe and American textiles exporters did not enjoy just-in-time logistics in the 1950s - obscures the point that the networks through which Chinese factories supply the world are themselves key parts of the low-skill industrialization project. China isn’t knocking out 1970s style “cheap”. It has redefined the entire product cycle. C&S’s casual reference to “T-shirts” is telling. In today’s “fast fashion”, there is weight on both terms. Fashion and fast. China’s success in delivering on both at unprecedentedly high speed and at unprecedentedly low cost, isn’t a low-skill operation at all. If we see development trajectories not as the serial repetition of the same, but as distinctive, crafted projects that cumulate in complex agglomerations of skill, technology and labor, then this explains why the assumption that low-skilled manufacturing should follow the distribution of population flies in the face of all experience. As countless cases attest, low-wage, low-income developed economies are not by themselves the makings of a competitive production base. As Leon Liao puts it quite fairly: “International trade has never been allocated according to population. A country’s population gives it no natural claim to an equivalent share of global exports." And the remarkable fact is that Subramanian alone and with co-authors has long been making this point, not to pillory China, as is the case of the tendentious _Foreign Affair_s and Peterson pieces, but to highlight the great counterpart to China’s industrial success, namely India’s relative failure. The much-quoted Foreign Affairs piece showed low-skill export shares only for China, not for India. If you put both countries in the picture as Chaterjee and Subramanian have done on other occasions, the picture looks like this. China is far above the line, but India, almost as large in terms of population, is no less anomalous, just in the opposite direction. As far as global populations are concerned, and the imagining of tens of millions of “squeezed” jobs, it is this Sino-Indian pair that account for a huge share of the action. What this graph reveals is not China’s cheating, but India’s “greatest development failure”, at least this is the argument made Arvind Subramanian, this time in co-authorship with Devesh Kapur, in their major book, A Sixth of Humanity. Independent India’s Development Odyssey which appeared with Oxford University Press earlier this year. In this highly critical work on India’s development, China is repeatedly evoked, not to criticize but as a benchmark against which to illuminate what India’s political economy has not delivered i.e. large-scale formal employment for hundreds of millions of citizens. Kapur and Subramanian leave no doubt, if you want to understand why China, not India was the main driver of manufacturing globalization from the 1980s, don’t look to slots opening up in the division of labour thanks to the liberal mindedness of advanced economies, look to the contrasting political economy of the Maoist PRC and India’s post-independence political economy. As Kapur and Subramian note: The great divergence between China and India did not begin in 1978 with the Deng reforms—it was well underway by then. In one of the great ironies of modern history, the conditions created by Maoism turned out to be a great launching pad for industrial globalization. As the comparison of India and China in 1980 makes clear, to imagine manufacturing would be equally distributed when populations are so differently endowed in terms of educational and nutritional is fanciful. Here is the data from Kapur and Subramanian, data which I explored back at the very beginning of Chartbook. As Kapur and Subramanian insist, the striking fact is that even as India’s growth accelerated from the 1980s, structural change has not. Formal employment in India lags woefully behind. Why? As Kapur and Subramanian note, the path-dependent impact of India’s poor early start was devastating. The list of factors they mention is long and weighty: We argue for a new five-fold explanation applicable at different stages of Indian history: in the initial stages, the legacy of two key pre-1980s policies, the neglect of agriculture and the strangling of the domestic private sector, were critical. The failure of broad-based agricultural growth militated against rural industrialization, which would have been devoted to satisfying local needs that would have necessarily been labour intensive. Then, when the boom came after 1980, the thicket of regulation and broader labour protections that were legislated prematurely in a nascent democracy, underpinned by a deep ideological aversion to private capital in general and big capital specifically, became a barrier to attaining the size that would be necessary to compete globally. Similarly, the reforms after 1991, while wide-ranging, did not quite encompass non-tradeable inputs critical to manufacturing, namely, land, logistics infrastructure and power. A combination of low investment (logistics infrastructure), regulation (land) and the continued monopoly supply by state governments (power), combined with residual socialism, kept costs at 75–100 per cent above efficient supply. These factors were compounded on the supply side by the government, which dominated the formal labour market and established exorbitantly high wages at the lower end of the skill spectrum. This made their employment in the labour-intensive sector by the private sector less attractive. Finally, when the services sector and its exports boomed, wages soared even further via a Dutch Disease effect: one successful tradeable sector killed and cannibalized another less-skilled tradable sector, namely, manufacturing. Thus, scarcity-inducing policies of the planning era, precocious democracy and a Gandhian aversion to size; inefficient, monopolistic supply of critical non-tradable inputs; the behemoth of government; and super-successful skill-intensive services successively undermined India’s unskilled labour employment opportunities. The employment failure seems to have been over-determined. … Less quantifiable but no less important are some of the sociological factors that have undermined manufacturing and factory jobs. Take the impact of the success of the IT sector—located in urban areas with better working conditions, such as air-conditioned offices, good schools for children and attractive entertainment options. It became a more attractive place for engineering and management graduates to flock to. … Consider manufacturing and female employment. Indian society makes it difficult for women to work, reflected in India’s unusually low female labour force participation (elaborated in Chapter XIII). Indian society, in particular the routine harassment of women in public spaces, makes it even more difficult for them to travel long distances to take up work.37 Combined with onerous regulations on creating hostels and dormitories for women—which, in turn, prevents multiple shifts of operation—factories need to be located in areas with a large female labour pool. While firms can take apparel plants to female labour or bring them to the plants by building large-scale dormitories, this raises costs. If there was a case for subsidies to encourage labour-intensive manufacturing, housing subsidies to build dormitories for women workers would be a good place to start. All of this meant, that when opportunities did open up, in part thanks to adjustments in China, India was in no position to take advantage. Here is the account of the 2020s from Kapur and Subramanian. It stands in dizzying contrast to the one-sided, “China squeeze” argument delivered in the Peterson and Foreign Affairs pieces: In 2022, for example, India’s share of global exports in clothing (the canonical labour-intensive sector) was 3.1 per cent compared to 32 per cent for China. This is extremely disappointing because China started vacating export space in this sector after the Global Financial Crisis as its wages started rising; it then vacated further space in the aftermath of geopolitical developments that led investors to seek alternative investment locations. Between its peak and today, China lost about 7.5 percentage points of global export share (worth about $43 billion in 2022); over this period, India’s export share remained stagnant at 3 per cent, while that of Vietnam and Bangladesh rose by 3.5 to 4 percentage points. China’s loss did not translate into any gain for India in terms of low-skill exports and employment. Put differently, when the conditions for dynamism and prosperity were established after 1991, and even more tantalizingly when the global export opportunities opened up, it was as if India was a high-wage economy and only skilled labour could benefit from the dynamism. It had converted its physically abundant unskilled workforce into an economically expensive resource, penalizing its use. It is not my mission here to argue for or against Kapur and Subramanian’s interpretation of India’s development trajectory. The point in this context is simply that the “China squeeze” such as it is can only be understood, in relation to the heavy burden of domestic constraints that Kapur and Subramanian so unsparingly enumerate. I am concentrating here on India because it is the great counterpart to China and the unspoken reference point of the “China squeeze” discourse. But the point is more general. Can anyone with a straight face suggest that the main problems afflicting the development of South Africa or Nigeria, the great centers of mass underemployment in sub-saharan Africa, are cheap competition from China driven by Beijing’s industrial policy and an undervalued RMB? Likewise, is the main problem of the American working-class the threat of Chinese competition or the manifest crisis of social reproduction in the United States itself? The point here, as in the discourse around China shock 2.0 in Europe, is to insist that we should not normalize the world and pathologize China, without actually investigating what is going on in America’s industrial wastelands, the German car industry, or India’s lopsided labour market. One-sided pathologization should be understood for what it is, a polemical gesture. Concepts like China shock and China squeeze are, what Reinhart Koselleck, following Carl Schmitt, would have described as “asymmetrische Kampfbegriffe”, or “asymmetrical counter-concepts” or “asymmetrical combat concepts”. If the function of arguments like the “China squeeze” is to alert elites in the rest of the world of the need to rejuvenate and energize their development projects, so be it. But let us see the resulting discourses as the mobilizing interventions that they are. Interestingly, a significant slice of China’s public sphere - the so-called industrial party - have been obsessed for the last twenty years with precisely these questions of counterfactual economic history. Since the mid 2000s, a massive online discourse developed around an alternative history in which Chinese techno-patriots were asked to imagine how they would proceed if they had the possibility of traveling back in time to transport modern technology into the Ming dynasty (1368-1644) thus averting the “great divergence” of the 18th and 19th centuries. It is a fantasy of course, but also a goad. The point was not directed at Westerners. The alternate history is dramatically nationalist, but few n the West had even heard of it until recently. The adherents of the industrial party are not liberal moralists. They don’t project natural ladders of international development and ask why others don’t cede space. They take the Realpolitik of global economic development for granted. Their pointe was directed against fellow Chinese. The rallying cry of the alternative narrative was this: Now that we are beginning to gain steam and push forward on our national development path, now that we are breaking out of the inferior position assigned to us even in the early years following WTO accession, do not lose yourself in humanistic imaginings about better futures. In the spirit of Deng, they called on China to embrace the hard truth of development. Perhaps one might of the Industrial Party as a cultural trend born out of desire for symbolic revenge against those who had inflicted the century of humiliation. In terms of the various temporalities of the “China shock” - retrospective, prospective and counterfactual - one might think of the Industrial Policy discourse as truly speculative, conjuring up the China shock that never was. Or perhaps one might better think of it as imagining a world in which a powerful China was no shock at all, but simply a defining fact of modern history. I love putting out Chartbook. I am particularly pleased that it goes out for free to thousands of subscribers around the world. But, writing this newsletter takes a lot of work. If you are enjoying it and would like to support the project, sign up for one of the subscription options here. It is the equivalent of a fancy cup of coffee per month! Subscribe

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Aug 5 • 7:18 AM EDT • Politics • adamtooze.substack.com
Yankees news: Bombers close to securing $3B financing deal

Yanks close to securing $3 billion financing deal, new draftees make Yankees’ top 10 list, Chapman finally moves on

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Jul 16 • 5:00 AM EDT • Sports • sports.yahoo.com
Former OpenAI executive Fidji Simo joins Nscale board as company prepares for U.S. IPO

Fidji Simo joins Nscale's board as the London-based AI infrastructure company prepares for a U.S. IPO targeting up to $3 billion.

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Sep 16 • 7:39 AM EDT • Business • bizjournals.com
Starbucks Explores Majority Stake Sale in Japan Business at Potential $3 Billion Valuation

Starbucks (NASDAQ:SBUX) is considering selling a majority stake in its Japanese operations in a transaction that could value the business at approximately $3 billion, according to two people familiar with the matter. The company has invited several financial advisers to present options for the business and is open to relinquishing majority ownership, the sources told Reuters.

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Sep 16 • 6:06 AM EDT • Business • finance.yahoo.com
Long Lake, the World’s First AI Holding Company, Completes $6.3 Billion Acquisition of American Express Global Business Travel

Long Lake, the World’s First AI Holding Company, Completes $6.3 Billion Acquisition of American Express Global Business Travel

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Sep 29 • 8:28 AM EDT • Business • businesswire.com
Dating app Bumble closes deal to sell for $1.3B

Bumble, the Austin, Texas-based dating app company, has officially closed a deal that will see it acquired by Ithaca Holdings for $1.3 billion. Bumble announced the sale Tuesday morning, less

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Oct 13 • 5:05 PM EDT • Entertainment • thederrick.com
Carolina Panthers Unveil Rengderings For Expanded $1.3 Billion Stadium Renovation

The Panthers released renderings of their renovated stadium on Thursday as they hope to host major events in the future.

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Jul 23 • 2:45 PM EDT • Sports • foxsports.com
Hugging Face could be acquired for $13 billion amid AI boom

Hugging Face, an AI developer platform, has been exploring a potential $13 billion sale, highlighting its key role in the AI ecosystem.

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Aug 23 • 3:01 PM EDT • Business • businessinsider.com
University of Pittsburgh launches health sciences startup incubator in Oakland

Pitt trustees approved the incubator on the same day the university announced a $3 billion fundraising campaign to support university initiatives further.

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Sep 29 • 10:31 AM EDT • Health • yahoo.com
Mistral raises €3B as sovereign AI becomes big business

The French AI lab has raised €3 billion at a €21 billion valuation in a Series D round led by Samsung, Scaleup Europe and PSG Equity.

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Sep 8 • 10:17 AM EDT • Business • techcrunch.com
India's Manipal Health jumps 10.5% in market debut, valued at $9 billion

India's Manipal Health Enterprises made its market debut at a 10.5% premium on Wednesday, valuing the hospital ​chain at 857.63 billion rupees ($9.03 billion).

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Aug 5 • 12:25 AM EDT • Health • reuters.com
Starbucks considers selling majority stake in its Japan business: Reuters

Starbucks may sell a majority stake of its Japan business, their biggest overseas company-operated market, in a deal worth around $3 billion, sources say.

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Sep 16 • 11:36 AM EDT • Business • cnbc.com
Uber to acquire ezCater for $2.3B, expanding catering reach

Uber plans a $2.3 billion acquisition of ezCater to expand into catering, offering large order delivery for business events.

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Oct 6 • 10:51 AM EDT • Business • businessinsider.com
PayPal stock surges on reports of Stripe and Advent acquisition bid

PayPal shares soar as Stripe and Advent International reportedly propose a $53 billion acquisition, marking a major M&A offer in the payments sector.

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Jul 15 • 6:16 AM EDT • Business • businessinsider.com
‘CoCo’ would take taxpayers for a ride

Colorado wants taxpayers to spend another $4.73 billion on passenger rail. Don’t worry. They have a plan. Which is a little like your brother-in-law announcing he’s launching another exciting restaurant venture after his last three restaurants ended in bankruptcy. Please. Tell me where to send the check. This week the Front Range Passenger Rail District […]

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Jul 26 • 7:00 AM EDT • Politics • coloradopolitics.com
University of Pittsburgh launches health sciences startup incubator in Oakland

Pitt trustees approved the incubator on the same day the university announced a $3 billion fundraising campaign to support university initiatives further.

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Sep 29 • 10:31 AM EDT • Science • yahoo.com
Nvidia’s Israeli networking business is booming, and so is its economic footprint

The company’s networking revenue reached $32.3 billion in just the first half of fiscal 2027, already surpassing the previous full-year total. Much of the technology behind the business traces back to Mellanox and Nvidia’s Israeli development centers.

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Sep 7 • 7:16 AM EDT • Business • calcalistech.com
Novant Health’s economic impact hits $4.33B as Cape Fear population surges

Novant Health’s Coastal Region now generates $4.33 billion in annual economic output, more than triple what it reported a decade ago, according to an updated independent analysis by University of North Carolina Wilmington economist Mouhcine Guettabi.

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Sep 18 • 5:24 PM EDT • Health • wect.com
$75 million deal clears path for parking meter transfer vote today

Chicago aldermen are set to vote on the $2.53 billion parking meter transfer after securing a $75 million payment and a share of future revenue.

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Sep 24 • 7:00 AM EDT • Politics • chicagobusiness.com
Nvidia in talks to acquire Hugging Face in $13 billion deal, Business Insider reports

Aug 26 (Reuters) - Nvidia has been ​in ‌serious talks to acquire AI ‌platform ​Hugging ⁠Face in ⁠a deal that would value ​the company ⁠at ⁠more than $13 ​billion, Business ​Insider reported on ‌Wednesday, citing a person ⁠familiar with the matter. Reut...

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Aug 26 • 8:45 PM EDT • Business • kfgo.com
Tepper S&E’s tech-advanced experience center opens in support of Bank of America Stadium renovation

Tepper Sports & Entertainment’s tech-advanced experience center has opened for business in support of the $1.3 billion Bank of America Stadium renovation project.

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Jul 24 • 10:41 AM EDT • Entertainment • sportsbusinessjournal.com
'1.3 billion premature deaths': Scientists give frightening play-by-play of hypothetical Yellowstone supervolcano eruption
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Sep 21 • 11:18 AM EDT • Science • nypost.com
SBA Loan Defaults Surged at 2 Nonbank Lenders. $1.3 Billion Entered Liquidation

The Small Business Administration stopped non-bank lender exams just one week before lifting a nearly 40-year moratorium on admitting more of them into the program.

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Sep 24 • 11:35 AM EDT • Business • inc.com
Scientists have detected a strange signal that took 10 billion years to reach Earth. It has come from deep space near the dawn of time | BBC Sky at Night Magazine

Discovery of FRB 20240304B, a flash of radio waves from when the Universe was 3 billion years old, the most distant fast radio burst known.

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Oct 13 • 4:42 AM EDT • Science • skyatnightmagazine.com
Texas lawmakers weigh future of data center tax breaks

The cost to the state in lost revenue from data centers has grown from a $14 million estimate over a decade ago to a projected $3.3 billion in sales tax losses over the next two years.

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Jul 28 • 9:33 AM EDT • Politics • spectrumlocalnews.com
Samsung Stock Jumps Over 6% In Seoul as AI Memory Business Delivers Record Profit: 'Supply Constraints' Expected to Continue

Samsung Electronics Co. Ltd.‘s (OTC:SSNLF) shares rose on Thursday after the chipmaker posted a record second-quarter operating profit as surging artificial intelligence memory demand boosted its semiconductor business, though higher component costs weighed on earnings in its mobile division. Operating Profit Beat Estimates Operating profit climbed to a record 89.5 trillion KRW ($61.93 billion) for the second-quarter, beating the 88.13 trillion KRW ($60.98 billion) analysts’ forecast compiled by

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Jul 29 • 10:22 PM EDT • Business • finance.yahoo.com
Uber to buy US catering platform ezCater for $2.3 billion

Oct 6 (Reuters) - Uber said on Tuesday it would buy US catering platform ezCater in an all-cash deal for $2.3 billion, expanding its food delivery and workplace meals business.

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Oct 6 • 8:34 AM EDT • Business • kansas.com
Novant Health’s economic impact hits $4.33B as Cape Fear population surges

Novant Health’s Coastal Region now generates $4.33 billion in annual economic output, more than triple what it reported a decade ago, according to an updated independent analysis by University of North Carolina Wilmington economist Mouhcine Guettabi.

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Sep 18 • 5:24 PM EDT • Health • wcax.com
Nvidia confirms it's buying Hugging Face for $13 billion

Nvidia is buying Hugging Face for $12.9 billion, the companies said on Thursday, confirming Business Insider's previous reporting.

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Sep 3 • 8:21 AM EDT • Business • businessinsider.com
Designing Direct-to-Government Assistance: Three Case Studies in Global Health Financing

In September 2025, the US State Department released the America First Global Health Strategy, announcing a major shift in how the United States programs foreign assistance in one of its largest sectors, representing over $13 billion in FY 2024. Global health dollars, the strategy states, will now flow primarily to foreign governments, not to nongovernmental organizations (NGOs), as has been the case in recent decades. The Department has sought to advance this strategy by signing non-binding, multi-year memoranda of understanding (MOUs) with dozens of its largest aid recipients. While officials acknowledge that there will be real challenges to providing direct assistance in the near term, the explicit goal of these MOUs is to transition from donor-driven systems to partner government-led implementation.

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Aug 10 • 8:00 AM EDT • Health • cgdev.org
Princeton Equity Group secures $1.3 billion to fund franchise business

With $1.3 billion in commitments, Princeton Equity Group secured more than double the $575 million raised for its predecessor fund.

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Sep 29 • 12:58 PM EDT • Business • dallasnews.com
Georgian National Charged in US with Laundering $1.3B in Health Care Fraud Scheme

A federal grand jury in Boston has indicted a Georgian national on charges of conspiracy to launder proceeds from a $1.3 billion health care fraud scheme.

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Sep 6 • 8:14 AM EDT • Health • sovanews.tv
AZ's R&D chief Barr touts internal 'science success story' after IL-33 antibody's stellar showing in COPD

With a detailed data drop that AstraZeneca’s R&D chief described as an internal “science success story,” the British Big Pharma has secured an FDA priority review for what it believes could become a flagship biologic in chronic obstructive pulmonary disease (COPD). In detailed results from the late-stage Oberon and Titania trials—first teased in March and detailed in full at the European Respiratory Society Congress in Barcelona this week—the drugmaker laid out the extent of its IL-33 inhibitor’s potential to reduce moderate and severe exacerbations in a wide range of COPD patients still struggling with those “lung attacks,” as AstraZeneca’s Sharon Barr, Ph.D., called them, despite using standard-care inhaled therapy. In the headline results, a 300 mg dose of tozorakimab given once every four weeks curbed those moderate and severe exacerbations in the studies’ primary population of former smokers by 29% in the Oberon study and 34% in Titania. In the overall population of both current and former smokers, these reductions were 30% and 29%, respectively, versus placebo and inhaled standard of care. The benefits also extended to clinically meaningful exacerbation reductions in all prespecified patient subgroups and specifically turned up promising signals in patients across a range of blood eosinophil counts, with Barr telling Fierce that “it’s the details that make this even more exciting than the high-level results that we’ve already shared.” In fact, during AZ’s tozorakimab poster presentation at the ERS 2026 Congress this past weekend, attendees were so enamored by the data that event organizers had to encourage people to clear the room and look at the other presentations on offer, Barr said in an interview. “I think it really speaks to the fact that there is a lot of buzz around these data because the entire respiratory community has been so desperate for new therapies for these patients,” she explained. The respiratory disease continues to represent a “staggering unmet medical need,” Barr said, highlighting the COPD exacerbations that the Oberon and Titania studies homed in on, which she added carry a greater mortality risk than a heart attack. “When a patient has a severe exacerbation, only about half of them are still alive within three and a half years,” she pointed out. As for tozorakimab specifically, Barr christened the molecule “an AstraZeneca science success story,” harkening several years back to the point at which researchers began to explore IL-33 as a driver of respiratory disease, and COPD in particular. At the same time, “there was still so much that wasn’t understood,” she admitted, highlighting the insight that IL-33 signals through both ST2 and EGFR through the RAGE pathway, a discovery Barr attributed to AstraZeneca's own scientists. Understanding the need to tackle both pathways in COPD—and aware of competitor candidates in the hopper, including one that bound ST2—the company ultimately had to make some “courageous decisions,” Barr said. These included taking a prior COPD molecule offline and going back to the drawing board to reinvent its potential IL-33 label “to make sure that we had a molecule that could block signaling through both arms of the pathway, through both the reduced form and the oxidized form, knowing that we wouldn’t be first, but striving to be best.” “When we put [tozorakimab] into the clinic, we firmly believed that we had a differentiated molecule, and we saw the other molecules blocking just ST2 or partially blocking IL-33, unable to deliver two positive pivotal studies in COPD,” Barr explained. “We kept marching forward because we believed our molecule was differentiated, and now I think we have the clinical validation that supports that.” Ultimately, AstraZeneca finds itself on much better footing these days when it comes to potential biologic rivals to tozorakimab in COPD. Sanofi and Regeneron’s Dupixent, for instance, is approved to treat COPD exacerbations in patients with high eosinophil counts, but not low ones. Meanwhile, the future has become cloudier for other next-gen IL-33 candidates from Sanofi and Regeneron, as well as Roche, which have suffered trial flops in recent years. One other potential ingredient for AstraZeneca’s success in its duo of studies was that the company was “ambitious in the trial design, willing to look at an all-comers population,” Barr said, “and willing to enroll the most severe patients.” Prior studies for would-be biologics rivals in COPD “avoided enrolling” those patients, she pointed out. She also highlighted the Big Pharma’s painstaking design of exacerbations in its trial, which “gave us a very rigorous readout,” and pointed to “the extra effort and investment” the company put in to understand the effect of mucus plugs in patients. Barr described mucus production as a “key feature in disease diversity,” noting that mucus plugs—obstructing clumps of mucus that block patients’ airways—are associated with worse outcomes in COPD. In its data announcement, AstraZeneca noted that an integrated analysis of Oberon and Titania found tozorakimab “demonstrated a reduction in patients’ mucus plug score,” with the pharma claiming its biologic is the first to deliver such results in a broad COPD population. “So being able to reduce those mucus plugs, we expect, is an important part of driving benefit for patients who are living with COPD,” Barr said. Again touching on the breadth of the study populations, Barr added that tozorakimab “worked across all eosinophil levels in both current and former smokers across all levels of lung function,” which she suggested “really simplifies decision-making for clinicians, and it allows them to offer therapy to the broadest possible patient population.” In the highest patient eosinophil count group, tozorakimab helped chart a 43% reduction in exacerbation risk, which Barr stressed were “unprecedented data.” In the mid-level group, AZ’s drug delivered a 23% reduction and, in the lowest group, a 34% reduction in eosinophils, which Barr said suggests efficacy “in all patient subgroups.” As for AZ’s recent guidance upgrade on the medicine’s sales opportunity, the lift from a $3 billion to $5 billion range to $5 billion plus was informed by multiple factors, Barr said, including the fact that “in 2024, there were multiple competitors, and there aren’t anymore.” Additionally, “we know that this is a massive unmet medical need, and this is a really incredible set of data that we think will be very convincing to the clinical community,” Barr said. Looking ahead to a potential evolution of the COPD treatment landscape, Barr noted that most patients start treatment in the community with an option like a triple therapy, and for them, having an option like AstraZeneca’s inhaler Breztri will remain a “really important part” of that journey. But of the patients uncontrolled on triple therapy, which Barr described as “about half of them today,” just a “small fraction” are currently eligible for biologic therapy, which she emphasized AstraZeneca is working to change. Understanding that COPD is not a “one-size-fits-all” disease, AstraZeneca is also looking at its antibody drug Tezspire for patients with T2-driven disease, and the company continues to think about new mechanisms for tackling COPD through both systemic and inhaled drugs, Barr said.

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Sep 8 • 10:50 AM EDT • Science • fiercebiotech.com
Suncoast construction, softer tourism weigh on Boyd’s Las Vegas properties

Boyd Gaming generated $1.03 billion in revenue in the second quarter of 2026, in line year over year, but revenue was down for its Las Vegas locals and downtown Las Vegas properties.

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Jul 23 • 7:10 PM EDT • Business • reviewjournal.com
SpaceX’s High-Margin Software Business Could Soon Hit $33 Billion. Investors Are Underestimating It.

Wall Street is fixated on SpaceX's lockup expiration while analysts quietly model a software business inside the company that could dwarf Google Cloud by 2030. Here is why the market may be pricing the wrong asset entirely.

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Aug 12 • 7:35 AM EDT • Business • finance.yahoo.com
Nestle to raise €3 billion from spin off of its water business

Nestle said on Thursday it expects to raise around €3 billion ($3.43 ​billion) from spinning off its water business into ‌a 50-50 joint venture with U.S. investment firm Platinum Equity.

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Jul 23 • 1:51 AM EDT • Business • reuters.com
Royals $3 Billion Ballpark Development Gets Key Approval

The city council overwhelmingly approved three stadium-related measures.

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Oct 9 • 11:10 AM EDT • Sports • sports.yahoo.com
AAR bulks up maintenance biz in $1.3B deal

Aircraft parts and maintenance provider AAR is buying a majority stake in competitor MRO Holdings for $1.3 billion.

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Sep 29 • 1:40 PM EDT • Business • chicagobusiness.com