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Political newcomer Darline Graham wins South Carolina’s GOP Senate runoff
Her win in the snap primary to replace her late brother Lindsey Graham comes after President Donald Trump significantly boosted her campaign.
Flush with campaign cash, Uthmeier gets a boost from GOP attorneys general group
The Republican Attorneys General Association is pumping six-figures into the campaign
NVIDIA DLSS 4.5 Ray Reconstruction Review
NVIDIA DLSS 4.5 Ray Reconstruction boosts image quality with a new AI-powered model that uses 20% more parameters and 35% more compute, all without sacrificing performance. Our testing shows that ray-traced visuals are enhanced, offering crisper, richer textures, especially in path tracing.
Boeing’s New $131 Billion F-15 Contract Boosts Defense Business
Boeing was awarded a contract to maintain and upgrade its F-15 fighter jets.
Lone Star vibes: Six Flags Entertainment is returning to its Texas roots
Six Flags (FUN) will move its HQ to Arlington, Texas in 2027, boosting support for its parks network and operations—get the latest stock and strategy...
Creatine: is there truth behind the hype?
Creatine has become the go-to supplement for anyone wanting to give their fitness a boost and build muscle. It’s even made it out of the gym, with influencers touting its cognitive benefits. But what’s the science behind creatine, and does the evidence stack up? Madeleine Finlay hears from science editor Ian Sample and Dr Justin Roberts, professor of nutritional physiology at Anglia Ruskin University
AI for Science Shifts from Efficiency Boost to Systemic Reform of Research
AI for Science has entered its 'second half' — shifting from building AI-powered research tools to restructuring the entire research ecosystem, according to E Weinan, an academician of the Chinese Academy of Sciences.
First-of-its-kind PA program at UM hopes to boost rural health access
The University of Montana is making history with the launch of a new health care training program.The university is beginning its first week of classes for its
Trump to headline RNC fundraiser in Houston aimed at boosting Ken Paxton’s Senate campaign
An analysis by AdImpact suggests that Paxton, Democratic state Rep. James Talarico, and groups supporting both campaigns could spend roughly $440 million on the Texas Senate race, making it the second-most expensive U.S. Senate contest in history.
Highmark Health boosts Q2 operating income
Led by gains in its health plans and hospital subsidiaries, Highmark Health on Monday reported more than a six-fold increase in operating income for the...
The GTA VI “CyberLeek” leaks keep coming.
Despite Rockstar and Microsoft’s push to find the source, the GTA VI leaks continue to flow. These short clips show a player going on a mission to steal a conspiracy theorist’s truck with a bathtub full of gas, visiting a strip club and nudist town, and flying over Vice City at night. Other than boosting a crypto scheme, messages from the leaker(s) are calling for gamers to go to Rockstar offices and threatening to leak video of the other main character, Lucia. [Image: https://platform.theverge.com/wp-content/uploads/sites/2/2026/08/cyberleek-files-824.png?quality=90&strip=all]
A tiny “rainbow on a chip” could help supercharge 6G networks
Researchers have created a tiny chip that produces a stable “rainbow” of light capable of generating multiple high-frequency signals at once, potentially boosting the speed and capacity of future 6G networks. Its extreme precision could also make it valuable for quantum timing, navigation, radar, and even space-based technologies.
Mozambique strengthens regulation of medicines and imported vaccines, boosting health protection
Mozambique has reached a major milestone in strengthening the regulation of medicines and imported vaccines, with its national regulatory authority recognized by the World Health Organization (WHO) as having a stable, well-functioning and integrated regulatory system.The Autoridade Nacional Reguladora de Medicamentos de Moçambique (ANARME) has achieved Maturity Level 3 (ML3) for the regulation of medicines and imported vaccines under WHO’s global classification of national regulatory authorities.Mozambique becomes the 10th country in Africa to reach ML3, joining Egypt, Ethiopia, Ghana, Nigeria, Rwanda, Senegal, South Africa, Tanzania and Zimbabwe and marking further momentum in strengthening regulatory systems across the region.For people in Mozambique, stronger regulation means greater assurance that medicines and vaccines are appropriately evaluated for quality, safety and efficacy and monitored throughout their lifecycle. It also strengthens the country’s ability to identify and respond to safety concerns and substandard or falsified products, while supporting timely access to quality-assured health products.“Mozambique’s achievement is the result of sustained investment in regulatory capacity that will deliver crucial benefits for public health,” said Dr Sylvie Briand, WHO Chief Scientist and Assistant Director-General a.i. for Health Systems, Access and Data. “Strong regulatory systems protect people, build confidence in health products and help countries respond more effectively to evolving public health needs and challenges. Mozambique’s progress also contributes to advancing regulatory capacity across Africa and promoting more equitable access to safe and quality-assured medicines and vaccines.”Building a stronger regulatory systemMozambique’s achievement follows years of sustained efforts to build the institutions and capabilities needed for effective regulation.WHO worked closely with ANARME throughout this process, assessing the national regulatory system and supporting the authority in addressing identified gaps and strengthening priority areas.WHO evaluates national regulatory systems using its Global Benchmarking Tool (GBT), which assesses the regulatory functions required to ensure the quality, safety and efficacy of medical products. These include registration and marketing authorization, licensing, market surveillance and control, pharmacovigilance, regulatory inspection, laboratory testing and oversight of clinical trials, as applicable. WHO’s maturity levels range from 1 to 4. Reaching ML3 confirms a stable, well-functioning and integrated regulatory system, while ML4 represents an advanced system focused on continuous improvement.Benefits for Mozambique and the African continentAn ML3 regulatory system can support more timely and predictable regulatory decisions, reinforce safety monitoring and help ensure that health products entering and remaining on the market meet appropriate standards.It also creates greater opportunities for regulatory cooperation and reliance – approaches that help authorities make use of the work and decisions of trusted regulators, reduce unnecessary duplication and allocate limited resources more efficiently, while maintaining rigorous standards for quality, safety and efficacy.As the first Portuguese-speaking country in Africa to reach ML3, Mozambique’s experience can also contribute to strengthening regulatory systems and fostering greater cooperation, knowledge sharing and reliance among Portuguese-speaking countries and across the African continent. Its achievement further reinforces a more connected African regulatory ecosystem, providing a solid foundation on which the newly established African Medicines Agency can build to advance regulatory convergence and cooperation across the region.Strengthening confidence in regulatory recognitionMozambique’s achievement comes as WHO strengthens the process through which the performance of national regulatory systems is recognized.The newly established Technical Advisory Group on Regulatory Systems Strengthening (TAG-RSS) brings together independent international experts to advise WHO on whether recommendations concerning regulatory authorities reaching ML3 and ML4 and WHO-Listed Authorities, are supported by the findings of WHO evaluation processes. Its recommendations provide an additional level of independent assurance, strengthening the impartiality, transparency and credibility of WHO’s recognition process.Mozambique is among the first countries to achieve ML3 following consideration and recommendation by the TAG-RSS. As part of the same TAG-RSS process, South Africa was recommended to retain its ML3 status for the regulation of vaccines manufactured, imported or distributed in the country, following an additional WHO assessment. This extends the recognition first granted in 2022 and underscores the sustained performance of the South African Health Products Regulatory Authority (SAHPRA).The two recognitions highlight continued progress in strengthening regulatory systems across Africa, as well as the importance of continued performance, improvement and assessment in sustaining regulatory maturity.WHO will continue working with ANARME and SAHPRA to sustain these gains and support continuous improvement as science, technologies and public health needs evolve.
Sustainable ag, boosted health
Study finds mental, physical health and community benefits of program that works in ag with refugees, immigrants.
A final conversation with a Kansas political icon: In praise of local newspapers and community ties
Nancy Kassebaum, you see, was a fervent booster of local newspapers, and the reporting and commentary they contained.
ASU students return to Tempe boosting local businesses
Arizona State University students are returning to Tempe, bringing energy and business back to downtown restaurants and shops for the new school year. FOX 10's Irene Snyder checks out some local shops.
‘It is essential’: Collegetown businesses welcome back students, see business boost
With college students now back in town, the streets are busy again, and businesses in the Collegetown area say they’re starting to feel that “boost” again.
‘It is essential’: Collegetown businesses welcome back students, see business boost
Now that students are back, they’re ready for business to pick back up.
You no longer need clean install for a free Windows 11-exclusive performance boost feature
Microsoft removed the mandatory clean install requirement for a Windows 11-exclusive feature that's said to boost performance.
Scientists turn tiny “defects” into a 5.5x heat transfer boost
Scientists have developed an ultrathin coating that could dramatically improve how efficiently heat is transferred during condensation. By turning tiny polymer structures once considered “defects” into places where water droplets can form, then helping those droplets detach quickly, the new surface keeps exposing fresh areas for condensation. In tests on copper tubes, it transferred heat up to 5.5 times more effectively than conventional copper and more than 50% better than a standard water-repelling coating.
I burned out as a startup founder. My interns changed everything.
A startup cofounder says his unique connection with his summer interns pulled him out of burnout, boosted productivity, and made his startup better.
200,000 Veterans Leave the Military Each Year. The Government Wants to Help Those Starting Small Businesses
Bill Briggs, deputy administrator of the U.S. Small Business Administration, boosted programs like Micro Lender to give veterans a leg up.
Edmond business celebrates end of 11-month road construction project by holding re-launch
Edmond's Danforth and Kelley intersection reopens, giving businesses a much-needed boost after months of construction.
El Paso health officials urge vaccines as whooping cough cases rise in the city
Pertussis is resurging in El Paso: cases jumped from 0 in 2023 to 8 in 2024 and 19 in 2025, hitting infants and teens hardest. Health officials point to waning immunity and urge Tdap boosters.
This yeast supplement may boost cancer-fighting immunity
A simple yeast-based food supplement may help restore the immune system’s ability to fight cancer, according to new research in mice. Scientists found that yeast beta-glucan reprogrammed early immune cells in the bone marrow, leading to stronger, longer-lasting cancer-fighting responses against colorectal, skin, and breast cancer cells.
Why Agentic AI Could Expose the Leadership Gaps Holding Businesses Back
Agentic AI can boost productivity while exposing leadership gaps that require stronger guidance, accountability, and decision-making.
Broderick Jones can reshape his Steelers future vs. Jets
Pittsburgh Steelers offensive tackle Broderick Jones looks to reclaim a starting role or boost his trade value in the preseason matchup with the Jets.
Business activity expands at fastest pace since 2022
*/ /*-->*/ Stronger demand and improved sentiment boosted hiring to its fastest pace since January 2025, while easing input costs helped support growth.
3 minutes of sprinting does something 90 minutes of exercise does not
A few minutes of sprinting may reshape the bloodstream far more dramatically than a much longer moderate workout. Six 30-second sprints altered nearly a quarter of the blood proteins measured and more than 200 metabolites, while 90 minutes of moderate cycling produced far smaller immediate changes. Many of the proteins affected by sprinting were also associated with lower risks of obesity, type 2 diabetes, and other metabolic diseases.
2 foods to eat more of for better gut health and longevity: dietitians
There's no single best food to improve your health, but dietitians shared 2 favorite high-fiber foods to boost gut health and help prevent disease.
Retail sales fall despite World Cup and hot weather boosting alcohol and drinks trade
Rolling coverage of the latest events in global financial markets, the economy and major corporate moves
Google gives publishers a new way to fight AI-driven traffic losses
Google is giving publishers a new button that lets readers make them a preferred source across Search, Discover, and Google News, potentially boosting their traffic as AI search sends fewer clicks to the web.
Walmart says it will use billions in tariff refunds to keep prices low
Walmart said it received nearly $2.9 billion in tariff refunds and plans to use some of the benefit to support lower prices for shoppers, while the refunds also provided a significant boost to quarterly operating income.
Scientists crushed diamond beyond Neptune-like pressures—and solved a 20-year mystery
Extreme experiments have revealed how diamond behaves at crushing pressures beyond those inside Neptune and Uranus, resolving a decades-old conflict between theory and observation. The results could help scientists boost fusion energy output while revealing more about the exotic diamond rain hidden inside ice giant planets.
Elon Musk Is Expected to Point His Money Machine at Texas
Sources tell WIRED that Elon Musk is expected to spend up to $200 million in the midterms. It could be a big boost for GOP Senate candidate Ken Paxton, who’s struggled to raise cash.
$15 million project underway to boost business in New Orleans East
A privately funded $15 million development at Chef Menteur Highway and Crowder Boulevard in New Orleans East is set to bring national brands, local businesses, and retail opportunities to the area.
Downtown Dunedin businesses seek open-container entertainment district
Businesses are also urging the city to consider an open-container entertainment district and revive "Second Friday" events to boost local activity.
Drive for nuclear power boosts uranium industry — and tribal health concerns in southwest
For decades, White Mesa uranium mill has sparked debate over whether radioactive contamination threatens human health by getting into the water and air.
NASA Updates Next Steps for Commercial Swift Boost Mission
NASA and Katalyst Space announced Wednesday the LINK spacecraft will not capture or boost an agency satellite to a higher altitude.
Target receives $1bn boost from Trump tariff refunds
The US chain said it received a $994 million pre-tax reimbursement, which resulted in its second quarter operating income rising to $2.6bn.
The best Nordic Naturals supplements to boost your health
Nordic Naturals is family-owned and prides itself on focusing on science-backed supplements that address the areas of health that impact all human beings.
Coffee drinkers have less fat, more muscle, and surprising hormone differences
Coffee drinkers may be getting more than an energy boost. A Finnish study found that people who drank more coffee tended to have less total and abdominal fat, more muscle, and healthier metabolic markers despite having similar BMIs. Higher coffee intake was also linked to lower levels of certain amino acids associated with insulin resistance and type 2 diabetes risk.
World University Games a chance to showcase link between sports, innovation in the Triangle
While the 2029 FISU World University Games will undoubtedly provide a significant economic boost, their greatest value may be in showcasing the innovation, diversity and entrepreneurial spirit that define the Triangle.
Major sports events boost business near Chase Center, but lasting impact uncertain
Earth's Organisms Developed Via Evolution. Some Theorists Wonder: What if the Entire Cosmos Did, Too?
The idea that universes evolve like organisms sat on the fringes of theoretical physics for decades. Then, a Substack post and a 2022 find by the James Webb Space Telescope boosted the concept
Scientists who turned to OnlyFans to fund marmot research receive crypto boost
Funding boost worth $100,000 has recently materialized in form of new marmot-themed cryptocurrency
A Top Marathoner Needs Science to Win Big. He Comes to Wake Forest for Testing
When John Korir hit the track at Wake Forest University’s Kentner Stadium on a recent steamy summer afternoon, he needed to know one thing: Could he somehow tailor his training to boost his performance by 1%?
Try This Doctor-Approved Walking Routine to Preserve Bone Health in Mid-Life
In TODAY.com’s Expert Tip of the Day, an orthopedic surgeon breaks down how interval walking training can help protect bone density and boost heart health.
Highlands crime rates decrease following increased police presence and business crackdowns
City leaders and local business owners in Louisville’s Highlands neighborhood are pointing to a boost in police presence and stricter rules for late-night establishments as key factors in a recent drop in reported violence.
Paying for a Health App Boosts Engagement, but Not for Long
New research from Yale SOM's Kosuke Uetake finds that upgrading to the paid tier of a fitness app sparks a burst of activity that fades within weeks, rarely translating into long-term weight loss.
YouTube is changing how it counts views to give the numbers a boost
Watching one frame of a video will count as a view.
Athens business owners revitalize storefronts with new city grant
Seven local small businesses are getting a big boost thanks to a new city grant program designed to spruce up properties and foster economic growth.
Business split over whether SBTi’s new net-zero standard will boost action or dilute ambition
Five years since its initial launch, the Science Based Targets initiative’s (SBTi) flagship Net Zero Standard has undergone its first major update, prompting a mixed response from the climate community.
Could a drug designed for weight loss help athletes perform better?
GLP-1 weight-loss drugs can reduce weight and improve health, but could they also boost athletic performance?
Insurer reviews get an automation boost
The federal government's effort to modernize prior authorization is beginning to show up in the software doctors use.
Elite science high schools boost enrollment as AI, chip demand grows
South Korea's elite science high schools will admit a record number of students next year, expanding opportunities for young science talent at a time when unive
‘Spider-Man: Brand New Day’ leads domestic box office to stunning return to pre-pandemic form
‘Spider-Man: Brand New Day’ is leading the charge, along with ‘The Odyssey,’ in boosting 2026’s summer box office to historic new heights, with grosses 5.7 percent ahead of the summer 2019 box office.
Microsoft shares simple yet overlooked tip to help fix your slow Windows 11 PC
Microsoft reminds of a surprisingly simple yet overlooked tweak that could give your sluggish Windows 11 PC a much-needed speed boost.
Cowboys preseason crowds boost business at J. Gilligan's Bar & Grill
GLP-1 weight loss drugs may boost results but raise oral health risks, dentist warns
Jets activate 366-pound defensive monster ahead of 2026 season
The Jets received a major defensive boost Saturday, activating 366-pound tackle T’Vondre Sweat as the centerpiece of their blockbuster Jermaine Johnson trade finally gets on the field.
Scientists Made Protein-Packed Ketchup With Algae. Here’s Why They Did It.
Researchers added microalgae protein to ketchup, boosting its nutrition while discovering exactly how much algae flavor people will tolerate.
MacBook Neo 2 Release Date Will Boost Apple’s Spring Sales
The MacBook Neo 2 is expected to launch in Spring 2027 alongside the iPhone 18 and iPhone 18e. It's another step by Apple to split its professional and consumer hardware.
Republicans worry their chances of keeping Congress are slipping away. Inside the Trump campaign plan to change that
President Donald Trump has finally given the green light to pour millions of dollars from his personal PAC toward boosting vulnerable Republicans in November, two people familiar with the plans told CNN.
Democrats abandon deep-red state Senate races, boosting independents
Democratic Senate nominees in Nebraska, Idaho and South Dakota dropped out, clearing the way for independents. But Alani Bankhead in Montana declined to join them.
A doctor shares 4 bare minimum food rules to boost healthspan
Making small changes to your diet can make a big impact on your health, Dr. Ezekiel Emanuel said.
Santa Rosa launches downtown pilot program aimed at boosting local businesses
Santa Rosa kicked off a pilot program Friday night to bring life back into the downtown area. The goal is to help local businesses keep their doors open and flourish. But it's also an opportunity to bring community back to the city.
Trump visiting Long Island to boost Bruce Blakeman’s gubernatorial run with speech on crime
Trump is also hoping to bolster GOP chances of holding onto the House of Representatives in the fall midterm elections, although analysts say he could weigh down candidates in suburbs where he is deeply unpopular.
Miles ahead: China team boosts atom entanglement distance record fourfold
Donald Trump to give speech on crime and safety during New York visit
President visiting police academy in Long Island as he looks to boost Republicans in battleground races ahead of November midterms
NYC restaurant says year-round outdoor dining will help boost business
New initiative set to help small businesses grow in El Paso's Mission Trail
El Paso’s Mission Trail small businesses are getting an SBA-funded boost as Rep. Veronica Escobar, the County, Revby, and EFO Media launch hands-on marketing and technical assistance, from workshops to 1-on-1 support.
UF Diabetes Institute expands care across Florida with support from Google
UF Diabetes Institute Director Todd Brusko, Ph.D., speaks at Thursday's event announcing funding from Google.org to boost diabetes care in Florida. (University…
Two Surprising Fruits That Boost Heart Health (Without Raising Blood Sugar)
Here's what researchers found when pairing avocado and mango
Scheduling Dental Care During Prenatal Visits Boosts Oral Health Care During Pregnancy
Engaging vulnerable pregnant patients in oral health screenings and referrals can improve access to dental care
How local vendors are finding success at Providence Place
While mall vacancies have piled up, local vendors at Providence Place have pioneered a creative way to fill space and boost the local economy.
Common Health Coalition secures $100M from OpenAI Foundation to boost hepatitis C cure rates
The OpenAI Foundation invested $100 million towards a new public health initiative with the Common Health Coalition aimed at helping states and local jurisdictions close discovery-to-delivery gaps, | Funding will support the deployment of AI-enabled tools to help identify patients who have fallen out of care, reduce administrative burden, strengthen care coordination and improve patient outcomes.
The NSF’s Ph.D.-to-Industry Pipeline Push
The majority of STEM Ph.D.s take jobs outside academia. While some universities help them prepare, the National Science Foundation is now investing millions to boost those efforts.
Cyberattacks on US water systems raise alarms, but Congress faces hurdles on a fix
After recent cyberattacks targeted water systems, local leaders are urging Congress to boost protections before a more serious breach disrupts drinking water supplies.
Which hitter could be cut following possible star returns?
The Yannkees should at least receive a Belli boost soon.
India plans insurance reforms to rein in healthcare costs, sources say
India is weighing wide-ranging reforms of health insurance, from benchmarked treatment rates to a nationwide claims exchange, as it looks to boost transparency in a struggle to hold down some of the highest medical inflation in Asia, two sources said.
San Mateo County may require permit for businesses using humanoid robots
San Mateo County is considering a plan surrounding the use of humanoid robots to help firefighters put out fires caused by lithium-ion batteries.
NASA Swift Boost Spacecraft Prepares to Continue Mission
Katalyst Space uploaded a flight software update that reestablished attitude control of its LINK spacecraft, which is set to boost NASA’s Swift observatory.
Dietitian Shares No. 1 Plant-Based Protein to Boost Brain Health
These anti-inflammatory plant foods are also packed with protein.
Bilingual business network aims to boost Lowcountry startups with education and visibility
Bridge OKC Fund awards $794,750 to boost housing and mental health care in OKC
The Oklahoma City Community Foundation's Bridge OKC Fund has awarded $794,750 to three organizations that will fund housing and mental health care.The three org
US small-business sentiment rises to 11-month high in July, labor shortages a worry
U.S. small-business sentiment increased to an 11-month high in July amid a surge in the share of owners reporting plans to boost hiring, suggesting that last month's slump in nonfarm payrolls was probably temporary.
US small-business sentiment rises to 11-month high in July, labor shortages a worry
WASHINGTON, Aug 11 (Reuters) - U.S. small-business sentiment increased to an 11-month high in July amid a surge in the share of owners reporting plans to boost hiring, suggesting that last month's slump in nonfarm payrolls was probably temporary. The ...
Medical systems, health agencies get $80 million from feds to boost rural health
Dozens of projects from county health departments, healthcare systems and Maryland hospitals will share $80 million in new federal funding to improve access to healthcare in Maryland’s rural communities, the Moore administration announced Monday.
Doctors spanning the information gap to boost health literacy in Armenia
Council of Europe helps develop a more accessible and inclusive health system in the country
Reimagined night-call model boosts interventional radiologist well-being
Stanford University Medical Center has sought to alleviate burnout by rearranging its call model to minimize strain on physicians.
Uniper's first-half core profit rises on stronger gas business
German state-owned utility Uniper on Tuesday reported that core profit nearly doubled in the first half of 2026, boosted by the absence of negative impact on the group's gas business that had weighed on profits a year earlier.
Enterprise connectivity boosts AI performance and security
AI and cloud demands reshape enterprise connectivity. Optimum Business provides scalable solutions for secure and efficient network architecture.
Phillies gameday sponsorship delivers big brand boost for local business
Local companies advertising with the Phillies at Citizens Bank Park or with NBC Sports Philadelphia provides almost-unparalleled visibility in Philadelphia.
How injured Carlos Correa could return to Astros' lineup in 2026
Correa's return would be a huge boost for Houston's lineup.
AbCellera women’s health data top ‘most aggressive upside scenario,’ putting Astellas and Bayer on notice
AbCellera has reported phase 2 results “beyond even the most aggressive upside scenario” that its CEO dared to consider, boosting the biotech’s chances of challenging Astellas and Bayer for a women’s health market. The phase 2 clinical trial compared ABCL635, an antibody targeting NK3R, to placebo in patients with hot flashes caused by menopause. Investigators enrolled 92 postmenopausal women experiencing a mean of about 10 moderate or severe hot flashes per day. By Week 4, the number of moderate or severe hot flashes had fallen by a mean of 8.8 on ABCL635 and by 3.5 on placebo. That statistically significant, placebo-adjusted reduction of 5.3 hit the trial’s primary endpoint. The level of efficacy also cleared the bar set by existing drugs. While cross-trial comparisons can be misleading, AbCellera CEO Carl Hansen, Ph.D., had seen enough to start hyping the program. “We now view ABCL635 as a potential best-in-class non-hormonal therapy with strong differentiation against approved NK3R competitors across all important dimensions, including efficacy, safety, dosing and convenience,” Hansen said on a Monday morning conference call with investors to discuss the data. “We believe ABCL635 is now a highly de-risked program.” Last week, Hansen used AbCellera’s earnings call to set expectations for readout, with the CEO defining success as a clean safety profile and efficacy comparable to the two approved small molecules. The data vaulted over that bar. Astellas linked (PDF) one of the small molecules, Veozah, to placebo-adjusted reductions in hot flash frequency of 2.1 and 2.6 at Week 4 of its two phase 3 trials. Bayer reported (PDF) placebo-adjusted reductions of 3.04 and 3.29 at Week 4 of pivotal studies for its small molecule, Lynkuet. At 5.3, the placebo-adjusted reduction in AbCellera’s trial comfortably cleared the standard set by the incumbents. Veozah and Lynkuet came to market based on evidence of their ability to reduce the frequency and severity of hot flashes. AbCellera’s phase 2 study covered both endpoints, with the Canadian biotech reporting a mean reduction in severity of 1.4 points at Week 4 on ABCL635, compared to 0.3 points for placebo. Again, the placebo-adjusted result compares favorably to data on Veozah and Lynkuet. Analysts shared Hansen’s enthusiasm for the data. The phase 2 results “firmly validate ABCL635 as a potentially best-in-class treatment,” BMO Capital Markets analysts said in a note to investors Monday. ABCL635’s apparent efficacy edge “is likely attributable to the higher dosing/target engagement the asset is able to reach vs. the oral agents due to its wider therapeutic index,” the analysts added. The analysts, who model $2.3 billion in unadjusted peak sales for ABCL635, flagged the safety profile as another positive of the phase 2 readout. While Veozah carries a boxed warning for liver damage, nobody on ABCL635 in the phase 2 trial had elevated liver enzymes or bilirubin values. If replicated in phase 3, the lack of a liver signal could allow approval without the monitoring requirements imposed on Veozah. Investors appeared equally enthused, sending AbCellera's stock up 32% to $9.21 in premarket trading Monday from a Friday closing price of $6.93. Next, AbCellera will collect the Week 12 data and talk to its advisors about further development. The results open up “a wide variety of possibilities of how we might take this forward into phase 3 studies to truly maximize the value of the asset and make sure that ABCL635 is able to demonstrate its differentiation potential,” Sarah Noonberg, M.D., Ph.D., AbCellera’s chief medical officer, told investors.
Scientists discover a hidden switch inside silver nanocatalysts
Silver nanocatalysts have been found to switch where they perform their most important reactions depending on whether a solid oxide cell is making electricity or hydrogen. The discovery could enable smarter catalyst designs that boost clean power generation while making green hydrogen more energy-efficient.