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“We weren’t surprised,” one team source told The …

“We weren’t surprised,” one team source told The …

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Jul 2 • 2:16 AM EDT • Sports • sports.yahoo.com
All politics is local — even the Declaration of Independence

"What I found to my surprise," said Maier, "was this mass of local 'declarations of independence,' the greater part of which come from Massachusetts."

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Jul 1 • 10:08 PM EDT • Politics • commonwealthbeacon.org
WHO, Member States discuss expanding South-East Asia Emergency Health Fund SEARHEF

With climate-related disasters, disease outbreaks and other health emergencies becoming more frequent and complex across South-East Asia, WHO and Member States today discussed measures to strengthen and expand the South-East Asia Regional Health Emergency Fund (SEARHEF) to ensure countries have rapid access to life-saving support when crises strike. "Health emergencies are becoming more frequent, more complex and more costly. Countries need rapid, flexible financing that can be mobilized immediately when lives are at risk. SEARHEF represents regional solidarity in action, enabling Member States to support one another when emergencies strike," said Dr Catharina Boehme, Officer-in-Charge WHO South-East Asia Region. She was addressing the Fifteenth Meeting of the Working Group on the Governance of SEARHEF.

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Jul 1 • 8:00 PM EDT • Health • who.int
Arkansas business conditions index rises in June

The broad Creighton University Mid-America Business Conditions Index ticked higher in June despite a rising number of manufacturing job losses, higher prices, and negative impacts from Trump Administration tariff policies....

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Jul 1 • 6:52 PM EDT • Business • talkbusiness.net
Local health experts explain cyclosporiasis rise in northwest Ohio, southeast Michigan

Local health officials are reporting a rise in Cyclosporiasis cases across southeast Michigan and northwest Ohio, with Lucas County recording approximately 65 cases and southeast Michigan reporting 170 total, including 90 in Monroe County and 33 in Lenawee County.

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Jul 1 • 6:02 PM EDT • Health • 13abc.com
Michael Weatherly to return to 'NCIS' after cancellation of 'Tony & Ziva' spinoff

Michael Weatherly is set to reprise his role of Tony DiNozzo in a season-long arc on 'NCIS.'

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Jul 1 • 4:00 PM EDT • Entertainment • ew.com
Alex Karp says AI models are 'irresponsibly oversold'

Palantir CEO Alex Karp said that "something has gone completely wrong" in the AI market. "The enterprises are just tired of it," he said.

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Jul 1 • 12:07 PM EDT • Business • businessinsider.com
Haleon teams up with Microsoft in 5-year AI pact to upgrade consumer health operations

Consumer health giant Haleon has tapped Microsoft to incorporate AI across its operations, joining a growing wave of healthcare and life sciences heavyweights turning to Big Tech to execute enterpr | Consumer health giant Haleon has tapped Microsoft to incorporate AI across its operations, joining a growing wave of healthcare and life sciences heavyweights turning to Big Tech to execute enterprise-wide digital overhauls.

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Jul 1 • 10:14 AM EDT • Health • fiercepharma.com
Surprise Mario Kart World Update Ends A Drought Of New Content

It only took a little over a year.

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Jul 1 • 10:14 AM EDT • Technology • gamespot.com
Democratic socialist Melat Kiros defeats longtime House incumbent in Colorado primary

Kiros, a 29-year-old lawyer turned doctoral student, is the latest candidate to rise from the party's left flank and boot establishment-backed candidates.

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Jul 1 • 9:27 AM EDT • Politics • pbs.org
Meta Stock Rises on Report It’s Building a Cloud Business. CoreWeave Drops.

Meta rises on a report that it hopes to generate revenue from selling excess computing power to third parties. CoreWeave and Nebius are falling.

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Jul 1 • 9:05 AM EDT • Business • barrons.com
Content Independence Day, one year on: building the business model for the agentic Internet

One year after declaring Content Independence Day, a dynamic market for monetized content has officially emerged. In this report, we examine how the rise of autonomous AI agents is upending traditional search referrals and detail the new infrastructure required to support a sustainable web economy.

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Jul 1 • 9:00 AM EDT • Business • blog.cloudflare.com
I thought I was raising a confident girl. Then her words surprised me.

My young daughter doesn't think she can become a doctor because she's a girl. I don't know how this got into her head.

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Jul 1 • 6:26 AM EDT • Business • businessinsider.com
Ovaries Appear to Develop an Incredible Second Role After Menopause

The human body continues to surprise us.

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Jul 1 • 12:03 AM EDT • Science • sciencealert.com
The Four Business Outcomes That Break When Enterprises Stop Validating Their Defenses - SPONSOR CONTENT FROM AWS AND TERRA SECURITY

Sponsor content from AWS and Terra Security.

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Jun 30 • 3:11 PM EDT • Business • hbr.org
Millions drop Obamacare health coverage after subsidies expire and costs rise

Experts share why millions of people lost their Affordable Care Act health insurance plans this year after federal subsidies expired.

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Jun 30 • 11:05 AM EDT • Health • abc7.com
Millions drop Obamacare health coverage after subsidies expire and costs rise

Experts share why millions of people lost their Affordable Care Act health insurance plans this year after federal subsidies expired.

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Jun 30 • 11:05 AM EDT • Health • 6abc.com
Nokia, SAP and Microsoft Enter Strategic Multi-Year Agreement to Advance Cloud- and AI-Driven Business Transformation

Nokia will accelerate its enterprise transformation using RISE with SAP Methodology, with SAP S/4HANA hosted on Microsoft Azure.

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Jun 30 • 9:00 AM EDT • Business • news.sap.com
Carnell Tate's impressive performance during Titans' OTAs draws praise

Tennessee Titans rookie Carnell Tate is turning heads at OTAs after the team surprised analysts with his high draft selection.

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Jun 30 • 5:11 AM EDT • Sports • sports.yahoo.com
Top GLP-1 prescription indications include sleep apnea, depression and kidney disease, study finds

A report from Trilliant Health looking at payer data found that, as prescriptions for the popular weight loss drugs spike, so rises the number of approved benefits.

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Jun 30 • 4:04 AM EDT • Health • healthexec.com
How the Chicago Bulls retooled their sponsorship business to meet CMO data demands

As sports sponsorship spending rises, CMOs are looking for hard evidence to justify their deals. Teams and franchise owners are responding, but there’s competition.

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Jun 30 • 12:01 AM EDT • Business • digiday.com
Cyclosporiasis cases on the rise in Monroe County, health officials say

An outbreak of Cyclosporiasis is spreading in Monroe County, health officials announced on Monday.

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Jun 29 • 8:39 PM EDT • Health • fox2detroit.com
5 takeaways from STAT’s investigation into microhospital operator Nutex Health

Read the takeaways from STAT's investigation into Nutex, which used the No Surprises Act to fuel a stunning financial turnaround.

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Jun 29 • 1:28 PM EDT • Health • statnews.com
Melon Ball hosts Goldpine in concert Friday

Goldpine will be appearing in concert at the Melon Ball at Watermelon Music on Friday July 3.

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Jun 29 • 12:39 PM EDT • Entertainment • davisenterprise.com
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About 3 million people have dropped Obamacare health coverage after subsidies expire and costs rise

The Department of Health and Human Services suggests the 13% drop is due to a federal crackdown on fraudulent enrollmentut, but health analysts believe it's more likely related to the Jan. 1 expiration of federal subsidies.

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Jun 29 • 12:12 PM EDT • Health • pbs.org
Templafy data reveals shifts in enterprise AI document workflows

Enterprises face AI challenges as generic tools cause content inconsistency and dilute brand identity, affecting business-critical document quality.

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Jun 29 • 10:35 AM EDT • Business • businessinsider.com
Liver health is the latest wellness obsession

Interest in liver health and sales of liver-focused supplements is soaring as people become more aware of the organ's role in overall health, and rates of liver disease rise.

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Jun 29 • 8:36 AM EDT • Health • businessinsider.com
World Cup 2026 exit leaves South Korean football in crisis

After crashing out of the World Cup, BBC Sport investigates the rise and fall of South Korean football.

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Jun 29 • 8:03 AM EDT • Sports • bbc.com
Meet the worst L.A. free-agent signing ever

There have been a lot of bad free-agent signing in L.A. sports history, but this one rises, or sinks among all the others.

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Jun 29 • 7:25 AM EDT • Sports • latimes.com
The Anti-Data-Center Movement Is Reshaping Michigan Politics

Climate activist Will Lawrence cofounded the Sunrise Movement. Now, he has shifted his focus in his attempt to compete for a swing-district seat by calling for a data center moratorium.

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Jun 29 • 6:30 AM EDT • Politics • wired.com
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Google Cloud to Offer Specialist AI Models for Science Research

Alphabet Inc.’s Google will start offering specialist artificial intelligence models from software company SandboxAQ through its cloud service, expanding enterprise and research access to technology designed to accelerate drug discovery, materials science and semiconductor manufacturing.

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Jun 29 • 6:00 AM EDT • Science • bloomberg.com
Millions drop Obamacare health coverage after subsidies expire and costs rise

Health analysts say the drop in enrollment was likely related to the Jan. 1 expiration of federal subsidies, which caused a surge in plan costs that resulted in many people being unable to pay their premiums.

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Jun 29 • 2:04 AM EDT • Health • ms.now
A Doctor At Home: The Rise Of Ambient Home Health Monitoring

There is significant opportunity to improve long term health outcomes with ambient home monitoring.

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Jun 28 • 10:30 PM EDT • Health • forbes.com
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Millions drop Obamacare health coverage after subsidies expire and costs rise

Hampton Roads Virginia and Northeastern North Carolina News, Weather, Traffic and Sports.

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Jun 28 • 9:05 PM EDT • Health • wavy.com
Andy Burnham’s meteoric rise tells us much about how politics and power are changing

The former may of Greater Manchester’s rise raises questions about the changing dynamics of political parties and leadership in an accelerated political climate.

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Jun 28 • 8:29 PM EDT • Politics • theconversation.com
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England facing children’s mental health ‘crisis’ as referrals hit 1m

Commissioner calls for overhaul of state support after reporting 10% rise in young patient referrals last year

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Jun 28 • 7:01 PM EDT • Health • theguardian.com
‘Color Book’: An exquisite character piece

Strong performances anchor this memorable indie drama

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Jun 28 • 2:12 PM EDT • Entertainment • davisenterprise.com
AI coding agents gain trust as developers skip reviews

AI coding agents like Cursor are increasingly trusted to work autonomously, with a rise in AI-generated code reaching production directly.

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Jun 28 • 10:00 AM EDT • Business • businessinsider.com
Meteor streaks across skies, causes bright flash Sunday morning

Early risers across southeast Louisiana were treated to quite a sight on Sunday morning when a brilliant flash of light streaked across the pre-dawn sky. Around 5:00 a.m., Storm Station viewers reported seeing what looked like a large, vibrant green ball with fire trailing behind it followed by a bright flash. When small space rocks (meteoroids) slam into Earth's atmosphere at high speeds, they create the light streaks we call shooting stars

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Jun 28 • 8:00 AM EDT • Technology • wbrz.com
Rise in cancer in younger adults may be explained by faster 'biological aging,' early study hints

Researchers report that younger adults with older‑than‑expected biological ages are more likely to develop early‑onset lung, gastrointestinal and uterine cancers, but more research is needed.

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Jun 28 • 8:00 AM EDT • Science • livescience.com
Peer Support May Be the Answer to the Mental Health Crisis

Peer support is the sleeping giant that may help us overcome the social and mental health crises we currently face.

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Jun 28 • 8:00 AM EDT • Health • psychologytoday.com
Americans now live longer in Democratic-held House districts. Here’s why

Even as health care issues rise in the 2026 campaign debate, new data show that far more House Republicans than Democrats represent districts where the most residents face major medical challenges — and lack health insurance.

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Jun 28 • 6:30 AM EDT • Health • cnn.com
Dispatch reporter Emma Wozniak covers real estate development, business

From lawsuits to high-rises to market trends, here's how Emma Wozniak covers real estate and business news in Columbus.

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Jun 28 • 6:00 AM EDT • Business • dispatch.com
UNC, NC State to get millions from sports betting; gambling deductions allowed in budget proposal

Not only would the tax on sports betting operators rise to 23%, but North Carolina would levy taxes on prediction market operators as well under proposals expected to be included in the state budget.

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Jun 28 • 5:30 AM EDT • Sports • wral.com
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What watching a sunset can do for your brain

Humans appear to see sunrises and sunsets "almost like bookends". Here's what a daily dose of golden hour can do for our memory, sleep and mood.

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Jun 28 • 5:01 AM EDT • Health • bbc.com
Maryland health insurance rates could rise 13.7% in 2027 under proposal

BALTIMORE — Maryland residents who buy health insurance through the Affordable Care Act marketplace could see higher premiums next year, with insurers requesting an average rate increase of 13.7% for

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Jun 28 • 5:00 AM EDT • Health • hanfordsentinel.com
Jaron 'Boots' Ennis knew his talent would always rise
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Jun 28 • 2:41 AM EDT • Sports • sports.yahoo.com
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Application deadline for 2026 RISE Up Harlingen Business Pitch Competition is July 6

The competition is a collaborative effort between the Harlingen Economic Development Corporation and UT Rio Grande Valley's Entrepreneurship and Commercialization Center.

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Jun 27 • 8:00 PM EDT • Business • riograndeguardian.com
Gunnar gives back: O's shortstop surprises local kid with specialized cleats

BALTIMORE -- The story of 11-year-old Declan Lefevre’s youth baseball career is inspirational. When Declan was about 4 years old, a doctor noticed his legs were different lengths. And it wasn’t something he would grow out of, either, which is something his parents -- father Jeff Lefevre and mother Nichole

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Jun 27 • 6:57 PM EDT • Technology • mlb.com
Morgan Stanley Raises PT on International Business Machines (IBM) Stock

International Business Machines Corporation (NYSE:IBM) is one of the Best Cloud Computing Stocks to Buy According to Hedge Funds. On June 23, Morgan Stanley lifted its price objective on the company’s stock to $267 from $225, and maintained an “Equal Weight” rating on the shares. As per the analyst, Dell and HPE earnings demonstrate that the enterprise server demand […]

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Jun 27 • 6:18 PM EDT • Business • finance.yahoo.com
Chicago faith leaders, businesses rally to collect supplies for Venezuela earthquake victims

In Chicago, pastors and businesses across the city are coordinating efforts to send aid after devastating earthquakes in Venezuela.

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Jun 27 • 4:13 PM EDT • Business • nbcchicago.com
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Millions drop Obamacare health coverage after subsidies expire and costs rise

NEW YORK — About 3 million fewer people in the United States had Affordable Care Act health insurance plans in February compared with the same time...

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Jun 27 • 2:39 PM EDT • Health • post-gazette.com
Millions drop Obamacare health coverage after subsidies expire and costs rise

About 3 million fewer people in the United States had Affordable Care Act health insurance plans in February compared with the same time last year, according to new federal data. In the report releas...

yahoo.com logo
Jun 27 • 1:51 PM EDT • Health • yahoo.com
Millions drop Obamacare health plans after subsidies expire and costs rise

New federal figures show that about 3 million fewer people had Affordable Care Act health insurance plans in February compared with the same time last year.

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Jun 27 • 1:51 PM EDT • Health • apnews.com
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Millions drop Obamacare health coverage after subsidies expire and costs rise

New federal figures show that about 3 million fewer people had Affordable Care Act health insurance plans in February compared with the same time last year. The Department of Health and Human Services...

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Jun 27 • 1:51 PM EDT • Health • bigrapidsnews.com
☹️ Negative (-11%)
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Millions drop Obamacare coverage after subsidies expire, costs rise

New federal figures show that about 3 million fewer people had Affordable Care Act health insurance plans in February compared with the same time last year

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Jun 27 • 1:51 PM EDT • Health • abcnews.com
Maia Reficco finds love in Mallorca in the first look at Anna Todd's 'The Last Sunrise' (exclusive)

EW has the exclusive first look at Prime Video's 'The Last Sunrise,' director Carlson Young's adaptation of the coming-of-age novel.

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Jun 27 • 8:00 AM EDT • Entertainment • ew.com
Trump news at a glance: president tests out a new ‘red scare’ ahead of midterms

Republican strategists believe rise of Mamdani could present opportunity to tag Democrats with most extreme views of the left – key US politics stories from Friday 26 June

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Jun 26 • 9:00 PM EDT • Politics • theguardian.com
Politics Unusual: Co-chairs of NYC-DSA, Rep. Malliotakis

In this episode of Politics Unusual, FOX 5 NY's political reporter Morgan McKay sits down with the co-chairs of New York City's Democratic Socialists of America to discuss their success on primary night. Also, a conversation with Rep. Nicole Malliotakis about the rise of democratic socialism and the direction the Democratic Party could take in the coming years.

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Jun 26 • 6:28 PM EDT • Politics • fox5ny.com
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Is the No Surprises Act working? Government watchdog is uncertain

The nonpartisan Congressional Budget Office said it needs more data to determine what savings the 2020 law is bringing to the U.S. healthcare system—but early data indicate it falls short of expectations.

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Jun 26 • 5:24 PM EDT • Health • healthexec.com
A World Cup watch party reconnected me with someone from my past

Jill Tucker taught English in Cape Verde 35 years ago, and was surprised when one of her former students recognized her at a World Cup watch party.

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Jun 26 • 5:05 PM EDT • Business • businessinsider.com
Apple Loop: iPhone 18 Pro Release Date, Hidden iOS 27 Features, iPhone Air 2 Details

This week’s Apple headlines: iPhone 18 Pro price and release date, hidden iOS 27 features, iPhone Air 2 specs, unexpected Mac and iPad price rises, how Apple wins AI and more...

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Jun 26 • 5:03 PM EDT • Technology • forbes.com
PlayStation hardware sales fall to their lowest May total since 2000

Price rises hit Sony's console sales, but 007 First Light and Switch 2 help US game spending to grow 3%

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Jun 26 • 1:37 PM EDT • Technology • gamesindustry.biz
MAI-Code-1-Flash for Copilot Business and Copilot Enterprise

MAI-Code-1-Flash, Microsoft AI’s in-house coding model, is now generally available for GitHub Copilot Business and Copilot Enterprise, building on its recent expansion across Copilot surfaces. Purpose-built for coding and optimized…

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Jun 26 • 12:35 PM EDT • Business • github.blog
Dragon's Dogma 2: Dark Arisen: What We Learned In Capcom's Showcase

Kento Kinoshita, Dragon's Dogma: Dark Arisen's original director, is returning for Dragon's Dogma 2: Dark Arisen

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Jun 26 • 10:31 AM EDT • Technology • kotaku.com
Enterprise AI spending grows, OpenAI leads, RBC reveals

RBC's latest CIO survey finds no AI token panic, no SaaSpocalypse, and surging enterprise AI spending, led by OpenAI.

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Jun 26 • 5:01 AM EDT • Business • businessinsider.com
How Perizaad Zorabian Left Bollywood And Turned Her Family's Poultry Business Into A Rs 120 Crore Enterprise

Perizaad Zorabian was at the peak of her career when she decided to quit acting and turned her focus to her family's poultry business

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Jun 26 • 4:49 AM EDT • Business • ndtv.com
CRAWFORD | Kenny Klein, beloved longtime Louisville sports information director, dies at 66

Klein's career spanned nearly four decades and helped shape the public face of Cardinals athletics through some of its greatest triumphs and most difficult crises.

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Jun 25 • 10:45 PM EDT • Sports • wdrb.com
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As San Joaquin County sees rise in rabid bats, public health says not to worry
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Jun 25 • 8:22 PM EDT • Health • cbsnews.com
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Dolly Parton makes surprise appearance — complete with a joke

Dolly Parton just made a surprise appearance, complete with her trademark humor, amid health issues.

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Jun 25 • 6:58 PM EDT • Entertainment • ew.com
Making Our Own Luck

We are cross-posting a piece that former NIH official Kris Willis wrote for Macroscience. Kris is now the President and Founder of the Woodley Park Institute, for which I’m a board member. Picking winners or hedging bets? Federal science agencies have long wrestled with the question of how to ensure their billions of dollars of grants and contracts result in maximum benefits for Americans. On the surface, it might seem that a goal-oriented, interventionist style of management would be the best policy: prioritize our most pressing problems and distribute funding accordingly.This top-down strategy creates a unique hazard, though: bad choices can send resources in the wrong direction, resulting in slow progress that impedes the delivery of tangible benefits to citizens. Moreover, if decision makers pursue an applied advance when the underlying scientific principles remain poorly understood, they risk costly failures and a loss of support for the research enterprise at large. Examples include Nixon’s 1971 War on Cancer, undertaken on the premise that a cure could be achieved in less than a decade, the drive to build an operational commercial fusion plant by the mid-1990s, and the National Plan to Address Alzheimer’s Disease, which failed to produce the effective treatments and prevention strategies promised by 2025. The contrasting laissez-faire approach is to hedge your bets. If the path to an advance is impossible to predict, then the wisest choice might be to distribute funding to as widely as possible. The main risk of this strategy is that spreading funding thinly may limit the resources available to the most promising research, resulting in the same negative outcomes as the interventionist approach: limited support for the most promising topics, slow progress, and delayed returns. In reality, at science agencies like the National Science Foundation and National Institutes of Health, program managers navigate between these two extremes, setting some funds aside to target high-priority areas and using the rest to cover the widest possible range of meritorious proposals. This middle path seems like the most rational way to proceed, but it still requires making choices. How much should be set aside for high priority topics? What should those topics be? How should we define merit? Expert opinion can provide a helpful guide, but leading experts can have remarkably different opinions about what matters and what should be prioritized. Moreover, experts and administrators alike can be risk averse, giving an edge to high-profile, well-established concepts. What’s really needed is a data-driven framework to help guide decision-making, one that doesn’t simply repackage prestige or incumbency. Recognizing breakthroughs years in advance Many breakthroughs fail to attract funding or recognition at the earliest stages of development. Katalin Karikó, for example, spent years struggling to win grants for work on mRNA that would eventually win her and Drew Weissman a Nobel Prize. Similar stories can be told about Jim Allison’s groundbreaking studies leading to the development of cancer immunotherapy, Stan Pruisner’s demonstration that prions can self-replicate without DNA, or Robin Warren and Barry Marshall’s proof that Helicobacter pylori, not stress, causes ulcers. Yet at some point, the scientific community recognizes and responds to transformative breakthroughs like these. How does that change happen? And what if science funders could identify the areas that are on the cusp of a breakthrough? Those questions led my collaborators and me to study how scientists responded to past breakthroughs. Based on patterns in that data, we developed a means of predicting future breakthroughs, using biomedicine as a proof of concept. It’s worth taking a moment to describe how our approach works. Briefly, our prediction process begins by grouping the 18 million or so peer-reviewed papers in PubMed, the authoritative database of biomedical research, into roughly 50,000 unique topics. A small subset of these topics are so widely acclaimed as breakthroughs that they have been recognized with a major prize like a Nobel or a Lasker Award. We theorized that studying the development of these outliers over time, especially before they gained acclaim, was the key to identifying future instances of them. After defining topics, we chose 21 representative breakthroughs and asked what they looked like before they won prestigious prizes. To answer that question, we re-ran our topic-mapping algorithm repeatedly, winding back the clock one year each time, stringing together the years to follow the progress of each field as it grew and advanced. We found that in each case, the years leading up to a discovery followed a pattern: a burst of papers on a new, rapidly evolving topic, many of which quickly became influential. These characteristics—the percent of papers that are new, the percentage of papers that are brought in from other topics, and the influence of each individual paper—can all be measured separately for any given topic. Together, they act as a predictive signal that is detectable an average of five years before a transformative discovery is made, and up to thirty years before the discovery receives a major prize. Scanning the current research landscape for topics that display this signal allows us to predict what work will likely produce a future breakthrough. Each year we analyzed includes four or five signals, a number that appears to have remained constant across a twenty year time frame. In their classic work on the sociology of science, Bruno Latour and Steve Woolgar established that the desire to participate in a major discovery is an important motivator for scientists as they consider whether they should take up (or abandon) a research problem. Although further work is needed, the simplest explanation for our results is that this behavior is widespread enough to detect at scale. A foundational advance, or something like it, draws the attention of scientists and causes them to change the direction of their research. They vote with their feet, staking their own reputation and careers by publishing on and citing the new idea. That upswell of interest is the foundation of our breakthrough signal. What kind of research does our model identify as a breakthrough? After building a model based on the patterns in our 21 preselected breakthroughs, we tested it by identifying all early signals of discovery from 1994 through 1997. Of the 18 signals we found in that time period, 17 can be traced forward in time to a breakthrough. Examples include super-resolution fluorescence microscopy (see the image above), the directed evolution of proteins and enzymes (Chemistry Nobel, 2018), and sequencing the human genome (National Medal of Science, 2008). The discovery of the role of leptin signaling in obesity is a particularly interesting case study. Around 1950, scientists noticed the existence of a type of lab mouse that suffered from a unique inherited form of obesity. When given the freedom to choose their own diet, these mice ate more than normal and preferred food that was high in fat. Researchers had few clues as to why the animals overate; early experiments pointed to the existence of a soluble ob factor found circulating in the bloodstream that regulated appetite, but its identity was unknown. In 1994, Jeffrey Friedman and colleagues identified and sequenced the ob gene, noting that the protein it encoded appeared to fit the profile of a circulating factor. A year later, a trio of high-profile publications demonstrated that ob was a hormone that regulated body weight and fat deposition by regulating appetite. One of these was co-authored by Friedman, who christened it leptin from the ancient Greek word for thin. Using our model, the data from 1996 make it clear this advance would become a breakthrough. Scientists had flocked to study the biology of the new hormone, generating the flurry of new papers and citations required to produce a signal. One of these demonstrated that serum leptin concentrations reflected the amount of adipose tissue in the human body, providing clinical validation of the earlier mouse studies. Before the identification of leptin, scientists were unable to point to a specific molecule that controlled appetite and adiposity, so that it was impossible to rule out non-physiological causes of obesity; its characterization fundamentally changed our concept of weight gain. In 2010, Friedman and fellow pioneer Douglas Coleman were awarded a Lasker for the discovery. Our work also identifies breakthroughs in clinical practice and behavioral and social sciences, even though these areas are less likely to draw the attention of major prize committees. One example that falls into this category is the introduction of endovascular aneurysm repair, a minimally invasive surgical procedure for the treatment of abdominal aortic aneurysm, a leading cause of death among Americans over the age of 65. Relative to the previous standard of care, it reduces in-hospital mortality by almost four-fold. In 2017, Timothy Chuter received the American College of Surgeons’ prestigious Jacobsen Innovation award for his multiple refinements to the technique. Another under-recognized breakthrough identified by our model is the development of standardized survey instruments to assess the quality of life for HIV+ patients. The antiretroviral cocktails introduced in the mid-1990s reduced AIDS mortality, but treatment came with serious side effects. The new evaluations showed that patients whose disease progressed had worse physical functioning than Americans with other chronic diseases, while those who were asymptomatic maintained a health-related quality of life on par with the overall US population. This evidence made it possible for patients and activists to argue that even in the absence of a total cure, and in spite of the side effects, alleviation of symptoms was a worthwhile priority for clinicians. My colleagues and I have failed to identify any significant recognition for the physicians and health policy experts who pioneered this advance, although in 2016, researchers called for the World Health Organization to set targets for good health-related quality of life as part of its framework to end the AIDS pandemic. From forecasting to funding How should science funders use our predictions? Any serious discussion of what we should do with this new capability needs to begin with an understanding of its limitations. We can’t (and shouldn’t) invest all of our resources in the small number of topics predicted to produce breakthroughs. Innovative new fields are born from existing ones; they rarely arise de novo. If funders don’t maintain a diverse portfolio, the breakthroughs of tomorrow will have no antecedents. Think of this as eating the seed corn, or killing the goose that lays the golden egg. There are also multiple goals of funding beyond basic scientific discovery, including translating discoveries into clinical practice, developing new technologies, supporting economic development, and training new scientists. The investments needed to accomplish these goals are likely different from those required to support emerging breakthroughs. Finally, we must be aware that we may not capture every instance of a breakthrough. The concept is fuzzy, and not every significant discovery is recognized with a major award. Further, breakthroughs are rare, meaning that our dataset is, by necessity, small. This makes formal estimates of accuracy challenging. Although our overall success rate appears to be high, any one signal may turn out to be a false positive. We found one apparent example: the development of the third generation COX-2 inhibitors, Vioxx and Celebrex, which were much celebrated in the early 2000s as effective but non-addictive pain relievers, meets all the algorithmic criteria of a breakthrough. Five years after it received FDA approval, researchers demonstrated that Vioxx was associated with serious cardiovascular complications, and the manufacturer voluntarily pulled the drug from the market. Celebrex remains available, although like other NSAIDs, it carries an FDA warning for increased cardiovascular risk. Decision makers who were overly focused on the breakthrough potential of this research might have wasted substantial resources nurturing an area that ultimately proved to be a failure—but so would those who relied on expert opinion at the time. That said, the potential benefits of funding the next mRNA vaccine or cancer immunotherapy years earlier than we might have are large. When we can’t assume the outcome of an action, it’s worth conducting an experiment. Can targeted support for areas that are poised to produce a breakthrough increase the return on scientific investment without cannibalizing future advances? With the necessary administrative infrastructure in place, conducting this experiment would be straightforward. First, identify all the breakthrough signals between 2018 and 2023, select half at random, and commit to a decade of investment. For biomedicine, a six year window should yield about 30 topics with the potential to produce a breakthrough. Providing strong support to half of these might be accomplished for $300 million a year. That’s roughly half of the recent annual budget of the NIH Common Fund or around 20% of the fiscal year 2025 budget for ARPA-H. After five years, then again at ten, compare to see which group — the one that was actively managed, or the control — produced more breakthroughs, and on what timescale. Although we used biomedicine as an example, the same experiment could just as well be run for physics, materials science, or any other discipline. Any attempt to undertake such an experiment should keep three points top of mind. First, we can predict the topic of future breakthroughs, but the people and vision for how to move the work forward are still important. In practice, this means success requires active program managers with the expertise to develop the science and the authority to do so, including by recruiting investigators. Second, we would be wise to learn from the failures of past attempts to fund transformative research. High among these are funding modestly repackaged work, confusing the genuinely novel with the merely unfamiliar, and relying too much on incumbent investigators. All of these risks can be mitigated by thoroughly and intelligently integrating high quality data into portfolio management. Finally, we need to have patience. Even with strong funding support, producing a breakthrough takes time. If supporting breakthroughs is the best way to nurture the birth of new fields, we also need to accurately describe and properly manage the other two stages, so that we invest wisely throughout the productive lifetime of ideas and divest once they reach the point of diminishing returns. We would benefit from more study of all of these phases, especially the transition from one to another. More research could answer questions like: When does a breakthrough become an established field? How do the availability of funding, the size and characteristics of the available workforce, and the accumulation of evidence that disagrees with prevailing models affect a field’s decline? Exactly how do old ideas give birth to new ones, and can we speed up the process? The more we understand about the dynamics of scientific progress, the better we can maximize the odds that our curiosity leads to results. I’d call that finding a way to make our own luck.

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Jun 25 • 4:48 PM EDT • Science • goodscience.substack.com
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Dolly Parton surprises fans at opening of her new travel stop amid ongoing health battle

Parton had to cancel her Las Vegas residency after announcing she was being treated for an undisclosed health issue.

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Jun 25 • 3:30 PM EDT • Health • komonews.com
UToledo Business Camp Hosts Pitch Competition

Dr. Terribeth Gordon-Moore, senior associate dean at the Neff College of Business, discusses the RISE Into Business summer enrichment camp that culminated in teams of high school students pitching their T-shirt business ideas to a panel of judges.

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Jun 25 • 3:17 PM EDT • Business • news.utoledo.edu
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Agentic-Native Platforms Are Creating A New Technology Business Model

For decades, the enterprise technology industry operated on a simple principle: software companies built products, and services firms helped enterprises.

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Jun 25 • 12:42 PM EDT • Business • forbes.com
Myles Garrett's Rise Could Fuel T.J. Watt's Next Steelers Surge

For years, T.J. Watt and Myles Garrett have been linked in one of the NFL's defining player rivalries. Now, with Garrett pulling ahead in recent seasons and Patrick Graham arriving in Pittsburgh, Watt has fresh reasons to respond. For much of their careers, Watt's production far outpaced Garrett's. That changed in 2023 when the Cleveland Browns hired Jim Schwartz as defensive coordinator and Garrett elevated his game to another level.

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Jun 25 • 10:02 AM EDT • Sports • sports.yahoo.com
Teen Entrepreneurs Develop, Pitch T-Shirt Businesses at Neff College of Business

The RISE Into Business summer enrichment camp brought teams of high school students to campus to explore marketing, finance, accounting and other core business skills.

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Jun 25 • 9:57 AM EDT • Business • news.utoledo.edu
Dolly Parton Makes Surprise Appearance Following Health Issues

Dolly Parton made a surprise appearance at the grand opening of her travel stop in Tennessee just one month after she canceled an upcoming Vegas residency due to health concerns.

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Jun 25 • 8:15 AM EDT • Health • today.com
Everything Announced At The 2026 Capcom Spotlight

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Jun 25 • 8:00 AM EDT • Technology • gameinformer.com
This beverage stock is likely to rise ahead of coffee business spinoff, Barclays says

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Jun 25 • 6:44 AM EDT • Business • cnbc.com
Palo Alto Networks CEO: Workers are in 'Darwinian moment' with AI

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Jun 25 • 4:35 AM EDT • Business • businessinsider.com
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CVS Health Foundation invests $1 million in Hartford nonprofits tackling community health needs

Local organizations receive Hometown Fund support to expand access to health care, food, housing and essential services

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Jun 25 • 3:00 AM EDT • Health • cvshealth.com
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Danville and Pittsylvania County officials have launched the Marcus Alert Program.

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Jun 24 • 7:02 PM EDT • Health • wset.com
Trump spoke with Live Nation CEO shortly before surprise Justice Department settlement, court filing reveals

Live Nation’s chief executive spoke with President Donald Trump less than a month before the ticketing and events giant reached a surprise antitrust settlement with the Justice Department that consumer advocate groups have largely panned.

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Jun 24 • 3:11 PM EDT • Politics • cnn.com
House Democrats’ anxiety rises after wins by Mamdani-backed candidates: ‘Are we going to let them take over the party?’

Top Democrats insist that they’re unfazed by the party’s forming a “Zohran Mamdani wing,” after the New York City mayor’s stunningly successful primary night.

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Jun 24 • 2:29 PM EDT • Politics • cnn.com
South Dakota business bankruptcies down, but closures and farm reorgs up

While post-pandemic Chapter 11 business bankruptcy filings in South Dakota are down, the number of business closures and Chapter 12 filings, common with farmers, have risen.

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Jun 24 • 12:34 PM EDT • Business • ktiv.com
Colts insider identifies potential 'surprise' starter on defense

One Colts insider identified a potential "surprise" starter on defense who could emerge during training camp.

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Jun 24 • 12:11 PM EDT • Sports • sports.yahoo.com
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50 Cent Diddy documentary alleges blame for Biggie, Tupac deaths

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Jun 24 • 11:04 AM EDT • Entertainment • centraloregondaily.com
Pat Kelsey & The Snub

Sunrise/ Sunset/ Since the beginning it hasn’t changed yet/ People fly high begin to lose sight/ You can’t see very clearly when you’re in flight — “On Your Way Down” Allen Toussaint To be honest I didn’t pay much attention initially when Pat Kelsey was first asked Monday morning about not being invited to attend […]

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Jun 24 • 10:17 AM EDT • Sports • sports.yahoo.com
Taylor Swift shocks crowd with surprise 'Love Story' performance, flashes ring at fiancé Travis Kelce's event

Swift joined country superstar Lainey Wilson on stage at Kelce's Tight Ends & Friends charity concert in Tennessee.

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Jun 24 • 9:06 AM EDT • Entertainment • yahoo.com
Governor Morrisey Announces $2.4 Million Investment to Expand Worksite Clinics Across West Virginia

CHARLESTON, W.Va. - Governor Patrick Morrisey today announced a $2.4 million investment to expand access to worksite-based healthcare services across West Virginia. Through the state's Rural Health Transformation Program (RHTP), the funding will expand employer-based health services and strengthen workforce participation as part of the Health to Prosperity (HTP) initiative. With this announcement, total funding opportunities and implementation initiatives under RHTP now exceed $88.5 million.

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Jun 24 • 8:00 AM EDT • Health • governor.wv.gov
The universe may be hiding conscious minds stranger than we can imagine

What if consciousness isn’t limited to brains like ours? Philosophers Eric Schwitzgebel and Jeremy Pober argue that consciousness could arise in many different forms of life, even in beings built from radically different materials than those found on Earth. Drawing on the vastness of the universe and the likely existence of countless alien civilizations, they suggest it would be surprisingly Earth-centric to assume that only Earth-like biology can support conscious experience.

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Jun 24 • 8:00 AM EDT • Science • sciencedaily.com
Jaguars coach explains what makes Liam Coen special

Who would have thought Liam Coen could ascend to this position so quickly? At least one coach wasn't surprised at all.

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Jun 24 • 5:05 AM EDT • Sports • sports.yahoo.com
Caitlin Clark's argument with her coach went viral. How did Indy sports reporters handle the story?

To anyone who’s familiar with WNBA coverage, it’s no surprise that a recent video of a mid-game disagreement between Caitlin Clark and her coach went viral.

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Jun 24 • 5:00 AM EDT • Sports • indianacapitalchronicle.com
German Ifo business sentiment rises in June

German business morale ‌rose in June, a survey showed on Wednesday, as companies assessed their ​current situation more positively ​and expectations were also somewhat less ⁠sceptical.

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Jun 24 • 4:16 AM EDT • Business • reuters.com
NBA Draft first round reaction: Winners! Losers! Surprises! Steals!
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Jun 24 • 2:03 AM EDT • Sports • sports.yahoo.com
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Darializa Avila Chevalier wins NY-13 Democratic primary, AP says

The district comprises parts of Upper Manhattan, including Harlem and Inwood, and parts of the Bronx, including Kingsbridge Heights.

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Jun 23 • 10:41 PM EDT • Politics • ny1.com
George Holani could be Seahawks biggest surprise player this offseason

Seahawks running back George Holani was named by ESPN as the player that has turned heads the most on the team with his play this offseason.

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Jun 23 • 5:33 PM EDT • Sports • sports.yahoo.com
Sabres' Alex Tuch conclusion could actually be a trade

This would be a surprise twist to the tale.

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Jun 23 • 4:05 PM EDT • Sports • sports.yahoo.com
Roku May Help Fox Avoid Aggregeddon

(Welcome to the “Most Important Story of the Week”, my bi-weekly strategy column analyzing the most important (but often not buzziest) news story of the last two weeks. I’m the Entertainment Strategy Guy, a former streaming executive who now analyzes business strategy in the entertainment industry. Please subscribe.) Scrolling through links over the last week, I stumbled across this fun headline: Wow. Formula 1 (the sport, not the docu-series) is the perfect “dog not barking”. As a reminder, each week in my Streaming Ratings Report, I call out the shows that miss every viewership chart. I dub them “dogs not barking”—like the Sherlock Holmes mystery—because without any data, we forget they even exist. This is in contrast to something like, say, a film flop—cough The Mandalorian and Grogu cough—where even underperforming at the box office is widely discussed here, there and everywhere. In the US, Formula 1 is now in “no public viewership data, so not discussed” territory. After moving to Apple TV from its former home of ESPN, basically no one talks about it. Apple did publish an initial, unsourced, unsubstantiated, (dare I say unserious) datecdote claiming more folks are watching Formula 1 on Apple than ESPN, but we haven’t gotten any updates since. This stands in contrast to when the sport streamed on ESPN, and ESPN PR provided weekly viewership figures. Formula 1 was, at best, a niche sport in America—averaging 1.3 million viewers in the Big Data Plus era—but now it’s basically anonymous. (And yeah, after moving to Apple, I very, very, very much doubt its ratings increased.) Unfortunately, that story isn’t quite big enough to warrant a section in today’s “Most Important Story of the Week” column, but I wanted to call it out, because otherwise, no one else will! Certainly, no one will write articles about the silence/ratings decline, unlike when they wrote breathless articles connecting the rise in viewership to Netflix’s Drive to Survive, including Reuters just last month. (This is a topic I’ve tried to provide a moderate/nuanced/non-hyped take since 2022.) Anyway, on to this week’s issue. I was a bit worried I didn’t have a juicy topic, then the Murdochs went out and did their Murdoch thing: buying Roku. So that’s the story of the week, and it happens to touch on quite a few themes of the streaming wars and the disruption therein. I’ll cover that, plus why more consolidation in Hollywood media looks likely, more good news on the Hollywood labor front, whether we’ll see an uptick in production in Los Angeles, some Broadway and theme park news, cellphone prices going up in the third world (and possibly everywhere), and more. Subscribe Most Important Story of the Week - Another Big Media & Entertainment Merger The story of the week is clearly Fox is buying Roku for $22 billion. I read a lot of good strategy takes on why Fox bought this streaming TV device maker—and I’ll have mine below—but what fascinates me more is how this deal connects to quite a few themes of the streaming wars, linking to everything from the pace of M&A to “aggregeddon” to Netflix’s recent M&A actions/inactions to the shift to advertising from pure play streaming and more. The only topic I can’t really connect it to is my old theory, “never bet against Rupert Murdoch” because he isn’t the one who did this deal; his son Lachlan inked it. (Do I think he provided advice, even at his 95 years of age? Sure.) That plus I have one additional piece of strategy for all entertainment players, inspired by this deal. So let’s dive into all those topics, starting with why I like this deal. Roku is a Great M&A Buy

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Jun 23 • 2:23 PM EDT • Entertainment • entertainment.substack.com
Kylie Jenner’s AI Meta Glasses Can Sing ‘Rise and Shine’

They use AI to sing “Rise and shine.”

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Jun 23 • 1:44 PM EDT • Technology • thecut.com