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'These are striking forecasts': Super El Niño keeps getting even more likely, and it could bring a humanitarian crisis
Forecasts point to the ongoing El Niño rapidly strengthening to a likely all-time record in the coming months, fueling temperature rises and extreme weather.
Orange-lipped monkey that roars and snorts deep in Congo rainforest is new species to science
A striking new monkey species, Colobus congoensis, was discovered deep in the Congo rainforest and has been scientifically described for the first time.
Dozens at an Ebola treatment center in northeast Congo go on strike over unpaid salaries
Some of the center’s health workers and those working on the ground began striking last week.
Scientists warn invasive Asian mantises are threatening Europe's wildlife
Two striking Asian praying mantis species that have rapidly spread across Europe have now been officially classified as invasive, raising new concerns about their impact on native wildlife. Boosted by climate change and urban environments, these fast-breeding predators are expanding northward, where they prey on native insects, pollinators, and even small vertebrates while also reducing native mantis populations through deadly mating interactions.
Striking Mass General Brigham home health clinicians picket outside headquarters: "We're at our breaking point"
While 4,000 Brigham and Women's nurses are locked out of the Boston hospital following a one-day strike, 450 home health clinicians are on day 3 of their week-long work stoppage.
Why Putin’s nuclear threats aren’t working anymore
Ukraine is striking deep into Russia and pressuring Crimea. Does Putin have any “red lines” anymore?
Supreme Court ruling likely means more political ads in Ohio
Thanks to the new U.S. Supreme Court ruling striking down limits on campaign finance restrictions, even more political ads will likely be flooding the airwaves ahead of the November election.
Zack Wheeler expresses frustration over All-Star snub after striking out 14 Reds: 'I feel like I've earned it'
Hospice Nurses Strike at Allina Health
Hospice workers at Allina Health in Minnesota are striking for one day in response to what they call unfair working conditions. The SEIU-Healthcare
Dodgers notes: Shohei Ohtani, Freddie Freeman, Yoshinobu Yamamoto
The Dodgers are riding high during their final homestand of the first half, taking a commanding 3-0 series lead over the San Diego Padres after shutting them out 3-0 on Saturday. The latter game’s success was done without Shohei Ohtani in the lineup, as the two-way superstar was absent after striking out nine hitters in […]
Two different parties, two strikingly similar immigrant stories. Lawmakers from both parties share what being American means
Supreme Court strikes limits on party spending in federal elections, backing GOP appeal
The Supreme Court on Tuesday erased limits on how much political parties can spend in coordination with candidates for Congress and president, striking down a federal election law that is more than 50 years old.
Supreme Court expands Trump’s power over the federal bureaucracy
The justices allowed the president to fire a Democratic member of the Federal Trade Commission, striking down a nearly century-old precedent intended to insulate independent agencies from political influence by the executive.
Jaguars’ New DT Compared to All-Pro Chris Jones
Jacksonville’s interior defense gains a high-upside disruptor in Ruke Orhorhoro, a raw Clemson product whose elite frame and athleticism draw striking comparisons to the Chiefs’ superstar anchor.
Bullseye! Enormous 'bow and arrow' galaxy is unlike anything radio astronomers have ever seen — Space photo of the week
Astronomers and citizen scientists have discovered RAD-BAARG, a radio galaxy with a striking bow-and-arrow shape, offering a rare direct view of a galaxy falling into the environment of a galaxy cluster.
Star Wars Eclipse "literally cannot be finished" without more staff, insist striking Quantic Dream developers
Striking staff at Quantic Dream have warned that if the studio proceeds with layoffs, its upcoming Star Wars Eclipse game "literally cannot be finished".
Star Wars Eclipse in danger of cancelation, claim striking Quantic Dream developers
Workers protested in Paris over proposed layoffs at the Star Wars Eclipse studio…
Quantic Dream Developers Strike to Save Star Wars Eclipse, Warning that 115 Layoffs Would Doom the Unfinished Game
Quantic Dream developers are striking to save Star Wars Eclipse, warning that 115 layoffs would leave the unfinished game without a future.
Scientists find thousands of earthquakes in a perfectly straight line in Alaska, revealing a hidden 'microplate'
Tiny earthquakes that emerge in a strikingly linear pattern revealed the Yakutat microplate, which may be focusing volcano and earthquake activity.
Cold water changes your cells, and science says it only takes one week - Futura-Sciences
A daily dip in cold water might do more than jolt you awake. A study from the University of Ottawa suggests that a week of cold-water immersion can shift how cells protect and repair themselves, switching on a kind of internal cleanup crew. It is a striking finding, but also...
Play Chaos Cubed Today
Chaos Cubed has landed in Minecraft! Explore a striking cave biome filled with bubbling sulfur pools, build with sulfur and cinnabar, and discover the sulfur cube’s curious appetite for blocks! From bouncing and sliding to explosive surprises, this unpredictable mob unlocks exciting new ways to build, compete, and survive. Play Chaos Cubed today in Minecraft!
105 mph?! Brewers ace Jacob Misiorowski posts another velocity record while striking out 15 in first career shutout
Jacob Misiorowski threw the four fastest pitches ever recorded by a starter in a single inning. It wound up being one of the best starts MLB has ever seen.
Touchscreen MacBook '100% Confirmed,' Says Reputable Leaker
Apple's first touchscreen MacBook is now "100% confirmed," according to the prolific Chinese leaker known as Instant Digital, who appears to have insider information from sources in the supply chain. The leaker made their definitive statement this morning in a Weibo post. Instant Digital has a good track record for Apple rumors and has provided some strikingly accurate information in the past, so it's always worth noting what they have to say about Apple's plans.
7-month-old baby killed after Israeli troops open fire on a car, Palestinian health officials say
The Palestinian health ministry said that a 7-month-old baby was killed after Israeli troops opened fired at his parents’ vehicle in the occupied West Bank, with the bullet striking the boy in the face.
The Virginia Supreme Court Chose Principle Over Politics: Katherine T. Bennett in RealClearPolicy - American Legislative Exchange Council
RealClearPolicy op-ed by Katherine T. Bennett examines Va. Supreme Court ruling striking a redistricting amendment over constitutional law.
Gravity Waves From Super Typhoon Sinlaku
Satellites observed striking upper-atmosphere phenomena generated by an intensifying tropical cyclone.
Trump won big with the White working-class. Now they’re souring on him.
In a striking shift, White voters without college degrees that voted to reelect Trump by a huge margin are now net-negative on his job approval.
The State of Politics: Wisconsin Republicans Have Plan to Win in November
Top officials outlined their game plan; it's about key issues and striking first.
The mental health benefit of striking up conversations with strangers
Nick Epley was commuting to work at the University of Chicago when he looked across the train and wondered: Why are all these people sitting elbow to elbow ignoring each other?
Cate Blanchett looks striking at Cannes Film Festival
The actor wore a black gown from Louis Vuitton with a black ruff that elegantly framed her face.
Scientists say house cats could help unlock new cancer treatments for humans
Scientists have cracked open the “black box” of feline cancer in a landmark study that genetically analyzed nearly 500 cat tumors from around the world. The research uncovered striking similarities between cancers in cats, dogs, and humans — including shared cancer-driving genes tied to aggressive breast cancers.
Black Women, Beauty Politics and the Power of Rage in 'Is God Is'
In one of the film’s most surreal scenes, the twins at the center of *Is God Is*—Racine, “the Rough One,” and Anaia, “the Quiet One”—pretend to be strippers for a room full of men. But while Racine is welcomed, Anaia is rejected because her scarred face disrupts the men’s fantasies. That moment crystallizes one of the film’s central questions: What happens when Black women refuse to shrink themselves for the comfort of others? In Aleshea Harris’ Gothic revenge thriller, ugliness becomes both a burden and a source of power, as the film transforms into a stereotype-busting meditation on misogynoir, beauty politics and righteous rage. As the twins travel cross-country seeking vengeance against the father who burned their mother alive, Harris layers the conventions of the revenge genre with distinctly Black feminist aesthetics. The film moves between absurd comedy, trap music, intimate sisterhood and brutal violence while interrogating the ways Black women are expected to manage their pain, suppress their anger and perform acceptability. Anaia’s scarred face and Racine’s consuming rage become mirrors of the same misogynoir that shapes Black women’s lives—whether through beauty standards, domestic violence or the demand to remain silent. What makes *Is God Is* so striking is its refusal to look away from the “ugly.” Harris insists that Black women marked by violence, scars and fury still deserve visibility, complexity and even divinity. The film embraces the “angry Black woman” and the “ugly” Black woman as figures worthy of space, power and humanity. In doing so, it expands the tradition of Black feminist filmmaking by asking viewers to confront the realities dominant culture would rather ignore—and to recognize the beauty, dignity and selfhood that exist beyond respectability.
4 most striking moments from Stephen Colbert's last show
Colbert's last episode on "The Late Show" featured celebrity cameos, shots fired at CBS, and a Paul McCartney-sung farewell song.
State of the Coast keynote urges adaptability for coast business leaders
Striking the right chord with business and community leaders when it comes to adaptability was the message of the seventh annual State of the Coast Symposium, hosted by the Gulf Coast Business Council.
Scientists reverse Alzheimer’s in mice with breakthrough nanotechnology
A new nanotechnology treatment reversed Alzheimer’s symptoms in mice by restoring the brain’s natural cleanup system. The specially engineered nanoparticles helped clear toxic amyloid proteins from the brain and repair the blood-brain barrier, which normally protects and regulates the brain’s environment. In one striking experiment, elderly mice treated with the therapy later behaved like healthy younger mice.
‘He Didn’t Wanna Finish The Cut’
UFC 328 did not go according to plan for Khamzat Chimaev. “Borz” dropped a competitive split-decision to Sean Strickland in the main event, coughing up his Middleweight title in the process. The Russian wrestler started strong with his dominant wrestling, but he tired quickly and spent most of the back half of the fight striking […]
For Trump in China, a tonal shift yields few results
Trump's homage and deference to Xi were a striking display of an often commanding president adapting to a new power dynamic, understanding China's rise and its emerging role in the world.
Q&A: Amal Kasry works to strengthen science where it’s most needed
For the UNESCO section chief, “striking a balance between global coherence and respect for national ownership and cultural diversity is both essential and complex.”
Scientists stunned: students discover the purest star born right after the Big Bang - Futura-Sciences
The Search for the Universe’s Oldest Star SDSSJ0715-7334 is a star so strikingly poor in elements heavier than hydrogen and helium, it could only have been born at the dawn of the chemical evolution of galaxies, not long after the Big Bang itself. Currently, astronomers believe it is the oldest...
Brain scans reveal a shocking difference between psychopaths and other people
Scientists have uncovered a striking brain difference linked to psychopathy: people with psychopathic traits were found to have a striatum — a brain region tied to reward, motivation, and decision-making — that was about 10% larger on average than those without such traits. Using MRI scans and psychological assessments on 120 participants, researchers connected this enlarged brain region to thrill-seeking, impulsive behavior, and a stronger drive for stimulation.
Bill Maher Shares Unhinged Theory on Alleged Jeffrey Epstein Note
The 'Real Time With Bill Maher' host pointed out a striking similarity in the note to President Donald Trump.
US job growth likely slowed in April as boost from temporary factors fades
U.S. job growth likely slowed in April as the boost from warmer weather and return of striking health workers faded, but that would not signal a material change in labor market conditions, with the unemployment rate expected to have held steady at 4.3%.
Graham Platner and Susan Collins Duel in High-Stakes Maine Senate Race Ads
In strikingly different ads, Graham Platner argued that “Susan Collins’s charade is over” while Senator Collins highlighted the economic benefits she has brought to Maine.
'SOL Shogunate' is a samurai space opera set on the moon, but with an aerospace engineer making sure it's 'getting the science right'
Chaos Manufacturing CEO Guy Costantini and aerospace engineer Taylore McClurg tell us about the process of creating a believable but striking lunar adventure.
Scientists boost strawberry flavor and nutrition without changing growth
A surprising genetic twist shows that boosting a seemingly ordinary “housekeeping” gene can dramatically improve fruit quality without any trade-offs. By increasing the activity of a tRNA-related gene in strawberries, researchers unlocked richer color, stronger aroma, and higher levels of health-boosting compounds like anthocyanins and terpenoids. Even more striking, these enhancements came with zero impact on plant growth, fruit size, or sweetness—avoiding the usual downsides of metabolic tinkering.
Fight Your Fight: EA SPORTS™ UFC® 6 Arrives June 19, Delivering Next-Level Fighter Individuality and Gameplay Depth
Powered by Fighters, UFC ® 6 Features Alex Pereira and Max Holloway Stepping onto the Cover Watch the Reveal Trailer HERE Electronic Arts Inc. (NASDAQ: EA) today unveiled EA SPORTS™ UFC® 6 , launching June 19, 2026 on PlayStation®5 and Xbox Series X|S. Powered by fighters, UFC 6 brings unparalleled fighter authenticity to players with true-to-life fighter movement and striking. Former UFC middleweight and light heavyweight champion Alex Pereira and former UFC featherweight and BMF champion Max Holloway headline the Standard and Ultimate Edition covers, ushering in a new era of fighter individuality appearing in gameplay, allowing players to fight their fight like never before. UFC 6 Standard Edition EA SPORTS™ UFC® 6 delivers the most realistic and authentic fighting experience yet. Athletes move, strike, and react like their real-life counterparts thanks to Markerless Capture and the next generation of Sapien Technology, setting a new standard for authenticity in the Octagon and a
Evolution isn’t random. Scientists find the same genes used for 120 million years
Evolution seems to follow a script more often than expected. Researchers found that distantly related butterflies and moths have reused the same pair of genes for over 120 million years to produce strikingly similar warning colors. Rather than altering the genes themselves, evolution modifies how they’re switched on and off. This discovery hints that life may evolve in more predictable ways than previously believed.
Ducks bring speed to challenge the playoff-tested Golden Knights
If the first round of the NHL playoffs played out almost exactly like the opening series a year ago when the Golden Knights eliminated Minnesota in six games, their next opponent is a striking reminder to the one they just vanquished. The Golden Knights again are the more playoff-seasoned team, but the Anaheim Ducks counter with a faster team interested in more of a track meet when their best-of-seven series opens Monday night in Vegas. Much like the Utah Mammoth, a team Vegas eliminated in six games on Friday night.
State redistricting battles intensify following U.S. Supreme Court ruling on Voting Rights Act
A Supreme Court decision striking down a majority Black congressional district in Louisiana has amplified an already intense national redistricting battle. Here’s a look at how some states are responding.
The Emergence of the High-IQ Political Attacker
In a shift from the past, more accused violent assailants have striking academic records. “We’re seeing a new breed of individual.”
Motorola Signature design highlight: Striking the perfect balance between form and function
This phone may look quite familiar, but it also proves that boring can be beautiful when executed this well.
King Charles’ subtle but striking warning to America
In a new age of revolt, it took a king to remind America of its republican values: the rule of law, democracy and the power of its international example.
Business Owner Slams This 'Embarrassing' Summer Job Trend From Parents
June Farms owner and reality series star Matthew Baumgartner is annoyed by a growing hiring trend — and his viral take is striking a nerve.
Wild Foxes review – animal-obsessed fighter at elite sports academy wonders if more to life than boxing
Valéry Carnoy’s striking film brims with unsynchronised ideas and images, but the physicality and performances of the young cast are undeniable
DNA reveals a hidden pitviper species in China
A vivid green pitviper hiding in Sichuan’s misty mountains has been revealed as a completely new species. Scientists had overlooked it for decades, assuming it was a common snake—until DNA analysis proved otherwise. Named after Laozi, it features striking differences between males and females, including bold stripes and eye colors. The discovery highlights just how many unknown species may still be lurking in well-studied regions.
Thailand’s Krabi Coast
The coastal province features striking tropical karst landscapes and sandy beaches alongside a mix of natural land cover and developed areas.
5 surreal and striking sci-fi anime to watch while you play Pragmata
Find your next favorite anime with these Pragmata look-alikes
Apple iPhone Fold: Release Date Leaked And Striking Design Revealed In Photos
What will the first folding iPhone look like? How big will it be compared to the current models? The first images claiming to be dummy units have just leaked.
‘I’m playing the long game’: Journalists are striking out alone and discovering the business is toughest beat of all
News Creators have become preferred sources for younger viewers, but how do they grow and sustain their independent endeavors?
Apple iPhone Fold: Release Date Leaked And Striking Design Revealed In Photos
What will the first folding iPhone look like? How big will it be compared to the current models? The first images claiming to be dummy units have just leaked.
NASA's Artemis II Crew Saw Meteorites Striking The Moon in Real Time
"Audible screams of delight."
NYT report details divisions inside Trump’s inner circle as the president weighed striking Iran
Alex Vindman internal poll shows him within striking distance of Ashley Moody
The Republican incumbent remains largely unknown to voters, according to a PPP survey.
MAGA Is Winning Its War Against U.S. Science
Source: NBER With all the other terrible news right now, you may not have noticed that Donald Trump is in the process of killing American science. OK, that’s an exaggeration — but not that much of an exaggeration. The Trump administration’s latest budget proposal calls for a gigantic increase in military spending combined with severe cuts to social programs. But as the chart above shows, it also calls for debilitating reductions in research funding. Furthermore, Trump appointees have already been strangling science by sharply reducing the rate at which research grants are approved. Here, for example, is the number of new grants approved by the National Science Foundation: Source: Nature Large numbers of existing grants have also been frozen or terminated, especially in the study of infectious diseases. Add to this a sharp drop in visas issued to foreign students, who often play a direct role in research and who help support academic departments that do research: Put all of this together, and much U.S. scientific research is set to come to a screeching halt — not a few years from now, but over the course of the next year or two. This new assault on U.S. science is taking place at a time when the role of American science in the world has already been greatly eroded. The chart below, based on research recently reported by the National Bureau of Economic Research, measures national strength in science by the share of publications in highly ranked journals. In the 1990s the United States had more such publications than the rest of the world combined. Since then we’ve dropped into third place — well behind China and slightly below the European Union. And this was before the Trump administration’s attack on science had time to take its full effect. Source Some erosion in U.S. scientific preeminence was inevitable given China’s growing sophistication and wealth. But we’ve also fallen behind Europe, even though everyone says that Europe is lagging economically and technologically. Claims about Europe’s underperformance are, in fact, dubious if one looks hard at the data. But it’s still striking to see America lagging. What’s going on? There are presumably multiple factors behind America’s scientific lag. But even before Trump II the growing hostility of the U.S. right to science surely had some negative effect. And since the rise of MAGA G.O.P. attitudes toward science in general have become overwhelmingly hostile. This is true even for the Republican rank and file: And while I haven’t been able to find good survey data, it’s obvious that the anti-science turn has been even more pronounced — and began earlier — among the Republican political elite. Chris Mooney published The Republican War on Science in 2005, and even then was describing a longstanding trend. Why have Republicans turned so anti-science? Part of the answer is that they believe that scientists don’t support them. And they’re right! A study of who scientists give money to shows that only a small percentage gave money to Republicans even 20 years ago, and that almost none of them donate to Republicans now: Social scientists have always been strongly pro-Democratic, while there used to be a significant number of physical, “hard” scientists supporting the GOP. But these days physicists are almost as uniformly Democratic, or at least non-Republican, as sociologists. Why are there almost no Republican scientists? It’s not a mystery. GOP political orthodoxy includes positions that are at odds with the scientific consensus on multiple issues, ranging from the validity of the theory of evolution, to the reality of climate change, to the efficacy and safety of vaccines. In each case the scientific consensus is solidly grounded in evidence. But even before the rise of MAGA the U.S. right was increasingly hostile to evidence-based policymaking — especially, of course, where the evidence is unfavorable to fossil fuel interests or quack medicine, both financial mainstays of right-wing politics. So scientists don’t support Republicans, and the feeling is mutual. Today’s Republican Party doesn’t like science or scientists. It doesn’t like having its preconceived views challenged by appeals to evidence. It knows that very few scientists are on its side electorally. In general, it sees scientific research as a threat to its grasp on political power. Add in MAGA’s combination of rabid anti-intellectualism and allergy to any hint of criticism, and one has the makings of a drastic anti-science turn in policy. “Ignorance is strength” might was well be an official MAGA motto. And as I said, we aren’t talking about something that will happen over the course of multiple years: The U.S. scientific enterprise is threatened with severe damage, even collapse, over just the next year. There are many reasons to find this prospect horrifying: Think of all the beneficial advances, affecting almost every part of life, that won’t happen because U.S. science — still crucial to the world — has been eviscerated. But think, also, of America’s international standing. Can a nation that has forfeited its role as a leader, or even a contender, in global science, still be a Great Power? No. MUSICAL CODA
Bordonaro: Legislature’s labor agenda risks hurting business competitiveness
With the Labor Committee approving 48 bills in six weeks, the cumulative weight of new scheduling rules, striking worker benefits and operational mandates risks making Connecticut a harder place to do business at exactly the wrong time.
After Gaza devastation, Israeli attacks on Lebanon's health care system feel familiar for many
SIDON, Lebanon (AP) — Two years ago, Dr. Mohammed Ziara watched Israel ravage Gaza's health care system, shelling hospitals, striking ambulances and forcing patients to evacuate.
Striking JBS workers to return to Colorado plant on promise of talks
Workers of the world's largest meat company, JBS , agreed to return to work at a beef plant in Greely, Colorado after it agreed to resume negotiations, bringing a three-week picket to an end, their union said in a statement on Saturday.
Meteor impacts may have sparked life on Earth, scientists say
Asteroid impacts may have helped kick-start life on Earth by creating hot, chemical-rich environments ideal for early biology. These impact-generated hydrothermal systems could have lasted thousands of years—long enough for life’s building blocks to form. Scientists now think these environments may have been common on early Earth, making them a strong candidate for where life began. The idea could also guide the search for life on other worlds.
Sky Sports: Liverpool must pay £87m to sign electric forward
Leipzig valuation puts Diomande among elite targetsLiverpool and Man Utd have been placed firmly on alert after RB Leipzig set a striking £87.3 million (€100m) valuation on highly-rated winger Yan ...
Hector Mujica enters CD 28 race, setting up potentially competitive challenge to Carlos Giménez
His switch from running for Senate to a Congressional bid follows polling that showed him within striking distance of the incumbent.
Scientists stunned by 'unprecedented' behavior in king penguins: 'It's quite striking'
"For the moment the species is able to cope with this change, but till when?"
Trump’s threats of targeting water plants in Iran, a potential war crime, alarm Gulf allies
After President Donald Trump floated on Monday the possibility of expanding the Iran war by potentially striking water treatment plants in Iran, some Gulf countries reiterated grave concerns to the Trump administration about any strikes on civilian infrastructure and the risk of an intensifying tit-for-tat escalation, according to four regional sources.
Coffee at night may increase risky behavior, especially in women
Drinking coffee at night might come with an unexpected downside: increased impulsivity. In a new study, fruit flies given caffeine after dark behaved more recklessly, ignoring signals that normally make them stop. Daytime caffeine didn’t have the same effect, pointing to a strong link between timing and behavior. Even more striking, females were far more sensitive than males.
Just a few minutes of effort could lower your risk of 8 major diseases
Just a few minutes of getting out of breath each day could dramatically cut your risk of major diseases—including heart disease, dementia, and diabetes. A large study of nearly 100,000 people found that it’s not just how much you move, but how intensely you move that matters. Short bursts of vigorous activity—like rushing for a bus or climbing stairs quickly—were linked to striking reductions in disease risk, especially for inflammatory conditions and brain health.
Scientists Stunned: Colossal Eggs Discovered 3,500 Meters Beneath an Active Volcano
Beneath an active seafloor volcano off Vancouver Island, researchers have documented a congregation of giant eggs at roughly 3,500 meters, a discovery that reframes how life can flourish under extreme conditions. The eggs belong to the Pacific white skate, an elusive deep‑sea species adapted to cold, crushing pressure and perpetual darkness. What seemed an unlikely nursery is actually a geothermally warmed refuge, where subtle heat helps embryos survive a marathon incubation. The finding links volcanic energy to a quiet engine of biodiversity, turning a hostile landscape into an incubator. A living volcano, a hidden nursery The seamount long assumed dormant now exhales mineral‑rich, shimmering plumes, proof of hydrothermal life at depth. Expedition cameras swept across black basalt and pale bacterial mats, revealing vents that pulse with warmth. That warmth, though modest by human standards, alters the physics of development for cold‑adapted embryos. In a realm where metabolism creeps, even a few degrees can mean faster growth and higher survival. The volcano is not only active; it is ecologically formative, drafting a blueprint for a thriving oasis. Giant eggs and a skate built for the abyss The Pacific white skate, Bathyraja spinosissima, is built for the abyss: broad wings, armored spines, and a life history that trades speed for endurance. Females lay outsized, rectangular “mermaid’s purses,” often 46–50 centimeters long, packed with rich yolk to fuel years of growth. In the frigid deep, embryos can require around four years to hatch, a timeline that magnifies every energetic advantage. The scale is striking—large eggs, large adults, and a textbook case of deep‑sea gigantism. The volcano’s gentle heat may literally shave months or years from the wait. Why heat matters at the bottom of the sea Hydrothermal circulation delivers low‑level warmth without the turbulence that would scatter fragile egg‑cases. Slightly elevated temperatures accelerate enzyme kinetics, nudging development along while keeping embryos within a safe range. Mineral‑laden fluids likely shape local microbiomes, which, in turn, can influence biofilms on egg surfaces. The environment acts like a slow, steady incubator, countering the deep sea’s tyrannies of cold and scarcity. For a species with long maturation and few offspring, every incremental boost compounds across generations. An ecosystem sculpted by fire and water Seafloor volcanoes create steep environmental gradients, stitching together hot vents, cool eddies, and mineral gardens into mosaic habitats. Microbes harvest chemical energy, seeding food webs that support crustaceans, fishes, and skates. Cameras documented egg‑cases nestled among rocky ledges, near communities nourished by vent‑driven chemistry. These islands of productivity behave like deep‑sea oases, sustaining life far beyond the vent orifice’s flickering light. The nursery’s success underscores how geological forces engineer biological opportunity. “Finding a cradle of life tucked beneath a breathing volcano reminds us that the planet’s harshest places can be profoundly generous.” What the discovery could change The nursery reframes conservation priorities in regions where volcanism quietly underwrites reproduction. Protecting hydrothermal corridors could safeguard entire lifecycles, not just charismatic adults spotted during occasional surveys. It also sharpens questions about how climate‑driven shifts in ocean circulation might influence vent activity, temperature fields, and embryo survival. With methodical mapping, time‑series cameras, and environmental DNA, scientists can track whether nurseries remain stable or drift with geologic rhythms. Key implications include: Enhanced understanding of deep‑sea reproduction at hydrothermal sites. New conservation targets centered on geothermal nurseries. Comparative studies with other volcanic regions, from the Galápagos to rift zones. Biotechnological insights from organisms adapted to long, cold development. Better models of how seafloor heat shapes regional biodiversity. Methods behind the revelation Remotely operated vehicles threaded through chimney fields, gathering video, temperatures, and mineral signatures. High‑definition imagery captured the distinctive, horned egg cases, their edges dusted with fine volcanic silt. Geochemical profiles mapped how heat and chemicals disperse, outlining the “thermal lanes” where eggs most cluster. Combined, these datasets reveal a nursery organized by geothermal topography, with egg‑cases concentrated in pockets of gentle, sustained warmth. A fragile boon in a changing ocean Deep‑sea environments feel remote, yet they intersect with global pressures: mining proposals, cable routes, and shifting oxygen levels. The nursery’s resilience hinges on stable heat flow, intact substrates, and minimal disturbance from noise or sediment. Safeguarding such places is not just about protecting novelty; it preserves a slow, ancient strategy that lets large, long‑lived animals endure in the coldest reaches of the Pacific. Where geology and biology meet, the planet’s deep time still writes living stories. This volcano‑warmed nursery adds a vital chapter to that story, revealing how subtle thermal gifts can tip the scales toward life in the abyss. With each dive, researchers trace the contours of an unseen world, where fire feeds water, and water—against all odds—feeds the future.
Rethinking brain-like artificial intelligence: New study reveals hidden mismatches
A new study by York University researchers has found a potential striking flaw in artificial intelligence (AI) models. Artificial neural networks (ANNs), a type of AI model built to solve vision tasks ...
North Carolina’s photo voter ID mandate can continue as a judge upholds the law
A federal judge has upheld North Carolina's photo voter ID law, rejecting claims by civil rights groups that discrimination against Black and Latino voters warrants striking it down.
Americans Broadly Disapprove of U.S. Military Action in Iran
Most Americans say striking Iran was the wrong decision and disapprove of Trump's handling of the conflict, with stark partisan divides.
Glyphosate: A story of science, risk, and nuance
In the summer of 2014, a California groundskeeper named Dewayne Johnson started noticing patches of raw, weeping skin spreading across his body. He had spent years applying Roundup, Monsanto’s glyphosate-based herbicide, for a school district, sometimes drenched in it when equipment malfunctioned. By 2014, he had a diagnosis: non-Hodgkin’s lymphoma. In 2018, a jury awarded him $289 million in damages, later reduced on appeal. Tens of thousands of lawsuits followed. The story hasn’t quieted down. It’s all over the internet, swinging between “this will kill you, buy organic” and “relax, you’re fear-mongering.” Some of that recent chatter stems from an Executive Order protecting glyphosate and its production, which set off intense infighting within the MAHA movement. Some of it reflects a deeper truth: Americans genuinely care about harmful chemicals in their environment (see poll below). And the conversation isn’t going anywhere, with a Supreme Court case involving Monsanto set for this April. Glyphosate (the active ingredient in Roundup) is one of the most widely used herbicides in the world. But does glyphosate cause cancer? And how much exposure is actually risky? With so much mistrust in institutions and corporations (and some genuine conflicts of interest), making sense of the actual scientific evidence is genuinely hard. Here is a translation of what the scientific evidence actually says. Does glyphosate cause harm? Glyphosate is an herbicide that kills most plants it contacts rather than targeting specific species. It works by blocking an enzyme pathway (EPSPS) that plants and many microorganisms need to produce essential amino acids. Without those amino acids, the plant can’t grow and dies. Glyphosate was first developed by Monsanto in the 1970s and became ubiquitous after the company introduced “Roundup Ready” crops in the 1990s. In 2024, Bayer removed glyphosate from residential Roundup-branded products due to litigation pressure. But today it is still the most widely used herbicide in the world. Farmers also discovered they could spray it directly on crops like oats, lentils, beans, and peas just before harvest to dry them out faster and make harvesting easier. Because of its widespread use, it’s obviously really important to understand if it’s harmful to humans. The key principle: The dose makes the poison The most important concept in toxicology is that “the dose makes the poison.” Sixteenth-century physician Paracelsus articulated what remains the foundational principle of toxicology: sola dosis facit venenum. Water will kill you if you drink enough of it. Aspirin saves lives at 81 milligrams and causes internal bleeding at higher chronic doses. So, at what dose is glyphosate poisonous? The LD50 in rats (the dose that kills half the test animals) is around 5,600 mg/kg body weight. Table salt is roughly 3,000 mg/kg. By that classic measure, glyphosate is less acutely toxic than salt. But some people are exposed to a lot of glyphosate through their work. And among the general public, there are many questions about low-dose, cumulative exposure from multiple sources over long periods. Does glyphosate cause health problems? Cancer Correlation maps are striking, with one analysis finding that 60% of counties that spray the most glyphosate have non-Hodgkin’s lymphoma rates above the national average. But correlation alone doesn’t establish cause, which is why animal and human studies matter. In animals: Rat studies are typically what most fear is rooted in, but most people don’t know the study details on the dosage given to rats. A pooled analysis of the 13 most rigorous rat studies found evidence that very high doses, around 55,000 times greater than typical food residue exposure, can cause certain cancers. In humans: One of the strongest studies followed 55,000 herbicide users over 20 years and found no overall increased cancer risk. There was one signal: among those with the highest use, rates of acute myeloid leukemia (AML) appeared elevated. A broader meta-analysis of 18 human studies also found no overall cancer risk, though a separate meta-analysis focused specifically on non-Hodgkin lymphoma found that people with high cumulative glyphosate exposure faced a 41% higher relative risk compared to those with low or no exposure. These human studies are observational studies (randomized controlled trials would be unethical), and meta-analyses are only as reliable as the studies they pool. But the story seems consistent: at very high exposure levels, there may be some cancer risk. But that’s about as far as the science currently takes us. Emerging research: gut and reproductive health Gut: Because glyphosate targets a pathway that exists in some gut bacteria, scientists have questioned whether it could affect the microbiome. In mice, a 2023 University of Iowa study found that glyphosate altered gut bacterial composition and raised markers of intestinal inflammation. A 2024 systematic review found similar patterns: disrupted gut bacteria and problems with the mucus layer that protects the intestinal wall in mice. Whether this translates to humans is an open question. The human gut is highly variable and resistant, and we don't yet have strong studies confirming the same effects in people. Reproductive health: Animal studies have found that glyphosate-based herbicides can interfere with reproductive hormones, including disrupting egg cell development in mice and reducing the number of eggs available in sheep’s ovaries. However, the doses used in these experiments were high, so it’s not yet clear whether the same effects would occur in humans. On the human side, a 2021 pilot study led by Mount Sinai researchers tested urine samples from pregnant women across the U.S. and found glyphosate in 95% of them. The study also found a possible connection between higher glyphosate exposure during pregnancy and a subtle physical difference measured in female newborns. That said, some connections weren’t statistically reliable and this was a small study. The researchers themselves said more and larger studies are needed before drawing firm conclusions. What do regulators say about glyphosate safety? In 2015, the International Agency for Research on Cancer (IARC), part of the World Health Organization, classified glyphosate as "probably carcinogenic to humans" (Group 2A). The classification is worth taking seriously. But, there’s an important distinction: IARC classifies hazard, meaning the potential to cause harm under some conditions. It does not assess risk, which accounts for actual exposure levels and the real-world probability of harm. The U.S. EPA, the European Food Safety Authority, Health Canada, and regulatory agencies in Australia and Japan have all concluded that glyphosate is “unlikely to be carcinogenic to humans” at realistic exposure levels. They’re asking a different question: given how much of this people actually encounter, what is the probability of harm? Your actual exposure is what determines your actual risk. What does glyphosate mean for your daily life? At the grocery store: Food residues are small. The EPA’s acceptable daily intake is 1.75 mg/kg of body weight per day. To hit that threshold from oatmeal alone, a 150-pound adult would need to eat roughly 50 pounds of oats every day. But this calculation addresses only one pathway (food), and we don’t yet have robust tools to measure people’s actual total exposure. If reducing exposure matters to you, organic certification prohibits synthetic herbicides, and organic oat products generally test at lower or undetectable levels. Either way, a diet rich in whole grains, conventional or organic, is far better for your health than one that omits them out of fear of residues. On the farm: Occupational exposure is orders of magnitude higher than consumer exposure. Farmers and farm workers who mix, load, and apply glyphosate-based herbicides, especially without protective equipment, face meaningfully different risk profiles. Proper PPE isn’t optional. Integrated weed management strategies that rotate chemical modes of action are also worth taking seriously, both for health and for long-term effectiveness. If you live near a farm: Spray drift is real. Concentrations near field edges can spike during and after application, particularly on windy days. This is an area where I think public health could really step up and empower rural communities with buffer zones, rather than placing the onus on individuals. But for now, knowing your local agricultural calendar and keeping windows closed during application are the first steps. Bottom line Dewayne Johnson was exposed to glyphosate at levels most people will never encounter, and a jury decided he deserved compensation. That outcome is not evidence that the oatmeal in your pantry is dangerous. But it is a reminder that the dose, the context, and the person doing the exposing all matter enormously. Glyphosate is a chemical tool with benefits, trade-offs, and genuine open scientific questions. Learning to hold that complexity without collapsing into panic or dismissal is, honestly, one of the most useful and hardest things to do in navigating modern health science. Love, YLE Your Local Epidemiologist (YLE) is founded and operated by Dr. Katelyn Jetelina, MPH PhD—an epidemiologist, wife, and mom of two little girls. Hannah Totte, MPH, is an epidemiologist and YLE Community Manager. YLE reaches more than 425,000 people in over 132 countries with one goal: “Translate” the ever-evolving public health science so that people will be well-equipped to make evidence-based decisions. This newsletter is free to everyone, thanks to the generous support of fellow YLE community members. To support the effort, subscribe or upgrade below: Subscribe
Marathon has sold 1.2M copies across Steam, PS5, and Xbox
Alinea Analytics estimates show that Marathon has generated gross revenues of $55M via 1.2M copies sold on Steam, PS5, and Xbox: Looking at the split between Steam, PS5, and Xbox, Steam is clearly the main platform for Marathon, accounting for a little under 70% of the audience (800K copies sold). Meanwhile, PS5 takes about 19% (217K) and Xbox (including console, PC, and cloud) accounts for a bit over 11% or 133K. Marathon is technically a first-party Sony title, so seeing the home console struggle to break 20% of the volume is a notable data point for the ongoing platform-agnostic debate. PlayStation Studios online games will almost certainly continue being multiplatform (despite Sony reportedly pulling back on PC releases). Subscribe for free to get the most accurate games estimates in your inbox twice a week 🫶 Subscribe As for Marathon, the consensus among hardcore players who pushed through the awkward onboarding phase – myself included – is that it’s fantastic. The gunplay, aesthetic, and presentation are among the best in the shooter genre. A great game doesn’t always equal an immediate hit, though, as shown by our estimates. Things are looking lukewarm right now. But this might be one of those marathon-not-a-sprint situations. Had to, didn’t I? Why wasn’t Marathon a hit on the same level as Arc Raiders? One topic that came up in a lot of conversations at GDC this year was why Marathon hasn’t hit the same stratosphere as Arc Raiders. On paper, they’re both extraction shooters, and Marathon has the Bungie pedigree – the house that built the gold standard for gunplay in Halo and Destiny. Marathon’s neon-futuristic aesthetic also distinguishes itself from the gritty realism of Tarkov or the post-apocalyptic hope of ARC Raiders. But vibes can only get you so far for first impressions if the onboarding feels like a brick wall. Marathon is a sweaty PvP-focused experience with a first-time user experience and UI that I can only describe as dreadful. Players are dropped into a complex ecosystem where the UI, though visually striking, is functionally uninformative, forcing users to manually hover over nondescript, identical icons just to identify basic gear or weapon mods. This lack of clarity is compounded by punishing mechanics like a severe heat gauge for movement and a scarcity of vital resources, all without a clear tutorial or a low-stakes mode to learn the ropes. Most people – even top streamers and veteran shooter players – have no idea what’s going on in Marathon at first. Arc is on the complete other end of the spectrum. As we covered here and here, Arc Raiders offers a more collaborative, approachable loop where players often work together toward shared goals. And the objectives are instantly clear. To many players, this contrast only emphasised Marathon’s issues, especially during the testing period. Players understand the Arc Raiders loop within 30 minutes, while Marathon acts as a massive filter, chewing up newcomers and spitting them out before they can experience the depth of Bungie’s signature gunplay. What I’m getting at here is that the poor first-time user experience of Marathon’s Server Slam likely stifled launch sales, while the opposite was true for Arc. Let’s look at the pre-launch copies sold for each game during their respective Server Slams (launch-aligned) : Looking at the trajectory: Arc Raiders saw a massive 80% jump in copies sold during its three-day Server Slam (day -13 to -11). Players jumped in, realised the water was fine, and immediately opened their wallets. Marathon, meanwhile, saw a 49% increase in the four days following its Slam (Day -7 to -3). At the time of each game’s respective launch, Arc Raiders had nearly double the Steam footprint of Marathon – and word of mouth only continued to grow. Bungie could have had more time to fix the onboarding process had the beta happened earlier. But Marathon launched three days after the beta finished. These factors limited the launch sales quite a bit, I reckon. Marathon has found a niche audience, though Despite the friction-heavy start, the data suggests that those who survived Marathon’s onboarding are loving life. We’ve been tracking cross-platform DAUs, and while there’s the expected post-launch leakage, many players are sticking with it. After peaking at 478K total DAUs on its first Saturday, Marathon has settled into a respectable rhythm, holding 345K DAUs as of yesterday and averaging 380K DAUs across the weekend. Steam continues to do the heavy lifting here, consistently accounting for the lion’s share of the daily players. Players have been putting in the hours, too: On Steam, Marathon’s average playtime has climbed to 27.8 hours, significantly outpacing the console averages on PS5 (16.5h) and Xbox (17.3h). Even more telling than the averages: 22% of the Steam audience has surged past the 50-hour mark, and nearly 7% have already logged over 100 hours. Subscribe for free to get the most accurate games estimates in your inbox twice a week 🫶 Subscribe This data suggests that once the Bungie magic clicks, it hooks players deeper than the average extraction shooter. There’s also started to be a shift in the game’s discourse. Marathon launched as one of those games that’s cool to hate. But as Marathon’s 100-hour club grows, we’re seeing conversations around its mechanical merit outweigh the negativity. Several high-profile creators, who were initially vocal critics, have spent the last week coming around on the mechanical depth of the endgame. It’s a subtle but positive signal; the hate train is losing steam, and a new narrative about the game is emerging. Bungie faithfuls unite Another interesting metric in Marathon’s first few weeks is who, exactly, is playing. Bungie leans heavily on its prestige as the “makers of Halo and Destiny,” in its marketing, and that message has clearly hit the mark. On Steam, the gravity (hammer) of Bungie’s previous work is unavoidable. A staggering 78.2% of Marathon players also played Destiny 2. The trend carries across other platforms, with 74.2% of PS5 players and 82.7% of Xbox players also having played Destiny 2. The Halo legacy lives on, it seems. More on that in a bit. While Destiny 2 went free to play, these numbers still represent a high-intent migration of a fanbase that trusts Bungie’s specific brand of kinetic gunplay and cryptic world-building. The Xbox data adds another layer of legacy. About 85.7% of Marathon players on Xbox have played Halo Infinite, while over half of the Steam audience has spent time in Halo Infinite and 36.1% in the Master Chief Collection (a paid collection of the old Bungie-made legacy games). Interestingly, we see a 55.9% overlap with ARC Raiders on Steam. Overlap is even higher there on PlayStation (60.5%) and Xbox (66.5%). And there’s also significant crossover with Helldivers 2 on all platforms, too. Subscribe for free to get the most accurate games estimates in your inbox twice a week 🫶 Subscribe Bungie has found some of its fans with Marathon, and the challenge now is keeping this engaged in a high-stakes PvP environment when they’ve spent the last decade primarily enjoying the power fantasies of PvE. On that note… Go the full 26 miles? Or cut and run? Time for some could’ve, should’ve, would’ve. These things would have improved Marathon’s performance at launch: A more robust onboarding process, perhaps in the form of a short single-player/PvE campaign. We know Bungie fans love this stuff. A traditional arena-based mode akin to Destiny’s Crucible could have been a bridge for the cautious players who’d have been otherwise deterred by the Server Slam. It’s also a great palate cleanser after getting merked. Introducing a dedicated PvE environment would have similarly diversified the conversation and lowered the barrier for the Bungie faithful who found the pure PvP extraction loop too abrasive. PvE is safer than PvP these days. There’s an argument that a thin PvE mode would have just felt like a budget Destiny, potentially hurting the brand more. But given how dire the FTUE is, I think it would have been a net positive. Any kind of tutorialised loop that demystifies the stakes, really. While there is merit in a studio sticking firmly to a singular creative vision, and going all in on the hardcore extraction loop. Less forgiving is the technical reality is that the user interface and first-time user experience (FTUE) were not at a commercial standard for launch. Subscribe for free to get the most accurate games estimates in your inbox twice a week 🫶 Subscribe In a landscape where player time is oversaturated and the most contested currency, a flawed FTUE is a critical failure point. But it’s not all doom and gloom, as Marathon has an incredible, unique gameplay loop, suggesting that financial success is still attainable if Bungie can pivot effectively. Bungie and PlayStation now face a difficult strategic crossroads, though – one within a challenging games market. They could: Double down on Marathon with a long-term Rainbow Six Siege- or No Man’s Sky-style recovery plan, which is something I heard Last Stand Media’s Chris Maldonado mention last week. While this could be a sunk-cost fallacy in action, it could eventually yield the audience the game’s mechanical depth deserves. Shift focus toward the inevitable Destiny 3 or another project, mitigating the escalating opportunity cost and cutting their losses, so to speak. Doing both is an expensive proposition, given the high overhead and burn rate of operating out of Bellevue, Washington. With Sony recently demonstrating a lower threshold for underperforming studios and projects, the margin for error has vanished. Whatever happens, the next six months will determine whether Marathon becomes a cornerstone of Sony’s live-service portfolio or a cautionary tale of vision exceeding accessibility. I’m hoping it’s the former, because Marathon rocks. As always, hit subscribe to get updates on Marathon and other relevant games. Subscribe Want to get your hands on our data for yourself – for free? We’re offering a free trial of our platform for games companies. Send us a message here, or reply to this email, and we’ll set you up. The last word Reply to this email – or reach out here – if you have any feedback for the newsletter – or want to request a game for us to cover. [Alinea Analytics boasts the most accurate PC and console estimates in the business. Game makers use our platform to understand their audience, keep an eye on the competition, monitor sales trends, and spot new opportunities. We equip game studios and financial institutions with accurate data and the confidence to make smarter, data-driven decisions. Want to talk about all things games market data? We’d love to chat!]
Your Thymus and Your Healthspan
Our thymus gland plays a central role in the development or our immune system, specifically for supporting T cell development (how these cells got their name, maturation and differentiation in the thymus) and discriminating between self and foreign, non-self antigen proteins with production of dendritic cells. As we age, our thymus gland shrinks—the process known as involution—with progressive change from spongy to fatty tissue, with loss of functionality. But this process, with respect to timeline and extent, markedly varies from one person to the next. And to make things even more complicated, our thymus gland anatomy and precise location in the chest also is highly variable. So the famous Frank Netter diagrams from the 1960s (such as at left below) don’t capture the remarkable heterogeneity that a random set of 12 chest CT scans (below at right). What I consider as 2 landmark papers in Nature this week (here and here) used AI to quantify health of the thymus in 2 large cohorts, and then correlate the metric to a broad array of health outcomes. In this edition of Ground Truths, I’m going to cover three questions: (1) How was thymus health determined by AI?; (2) How is thymus health linked to key clinical outcomes? and (3) Are there ways we can promote a healthy (aka rejuvenate) thymus gland in our later years? Subscribe 1. How was thymus health determined by AI? This was accomplished by extensive work developing and validating an AI pipeline for 2 stages, the first for localization and segmentation of the thymus bed, and the second to quantify a digital marker, termed the thymic health score. There’s a lot to this algorithmic development, so I won’t go into all the details, but just provide a rudimentary outline of what was done. The 1st stage used supervised learning with 2 radiologists reviewing 2,461 chest CT scans. That work trained a 3D U-Net model to automatically identify the thymic bed’s 3D cropped region using center of mass coordinates, which reached 99.8% accuracy. The 2nd stage used a foundation model that was pre-trained with SwAV (which stands for Swapping Assignment between multiple Views), a self-supervised model, that generated a high-dimensional thymus representation of 4,096 features. That compares to the radiology reductionist and subjective scoring of 0 to 3 where 0 means the thymus is fully degenerated and fatty, and 3 is considered dense, intact glandular soft tissue. Notably, the self-supervised learning (SSL) performance was superior to supervised (AUC ~0.75 vs 0.55, respectively) reflecting the shallowness of the 0-3 classifier vs SSL’s holistic, self-taught AI. The thymic health score ranged from 0 to 100, with the highest number indexed to fully preserved thymic health. The algorithmic work extended to explainability with both Shapely value distribution, meaning the model was holistic not relying on any “magic” pixel, and occlusion sensitivity, demonstrating the model’s performance was not affected by ribs, sternum, lung tissue, but rather focused on the thymic bed directly. Below are a few saliency maps from the occlusion sensitivity that indicate the thymic bed focus, not affected by neighboring structures, using the jet color scale. Now the AI was ready for processing ~25,000 CT scans, each over 30 MB files, from the 2 large participant cohorts to provide a thymic health score, it did so in less than 14 hours, which is less than 2 seconds per scan! Share 2. How is thymus health linked to key clinical outcomes? The two cohorts were the National Lung Screening Trial, NLST (N=25,031) and the Framingham Heart Study, FHS (N=2,581) each with baseline demographics and long term follow up of >12 years for health outcomes. From the NSLT, you can see below that increased age and body-mass index were correlated to reduced thymic health. And, overall, men had reduced thymic health scores compared with women. There are a lot of graphs in the paper for outcomes, for both the NLST and FHS cohorts. To simplify the major outcomes, below is a composite Figure with striking reduction of all-cause mortality and for the different causes of death. The results were consistent between the 2 cohorts. For example, the cardiovascular mortality hazard ratio average was 0.57 in NLST and 0.38 in FHS (weighted to be 0.53 for the aggregate). The reduction of mortality also extended to digestive diseases and pulmonary disease (data not shown below). Lung cancer incidence was reduced by 36% for high vs low thymic health (Figure below, with a panel -incidence and b panel-mortality, adjusted for age, sex, BMI, smoking status). Notably, there was a smoker’s paradox: lower incidence and improved survival for lung cancer in smokers who had a high thymus health score. Smoking was associated with lower thymic scores whereas alcohol was not. Higher thymic health was linked to higher HDL cholesterol, lower triglycerides, lower fasting blood glucose, and lower systolic and diastolic blood pressure. Inflammation biomarkers, such as C-reactive protein and interleukin-6, were elevated in the people with lower thymic health scores. In their second paper, the same team looked at the relationship between thymic score and outcomes for 3,476 patients receiving cancer immunotherapy. The non-small cell lung cancer progression-free survival was reduced in patients with low thymic health score. A parallel relationship for survival was seen for other types of cancer including melanoma, breast, and kidney with a 44% lower risk among high thymic scores (Figure). A similar pattern was seen with different immune checkpoint inhibitors. The thymus health score outperformed programmed death ligand-1 (PD-L1)and tumor mutation burden (TMB) assay of the tumor and was an independent prognostic marker of progression-free survival. In this dataset, a direct connect with thymus score and adaptive immune function was noted with a correlation before cancer treatment for both T-cell diversity and thymus T-cell production (a metric known as T cell receptor excision circles). Thymus Removal Study There is a highly relevant citation about thymus function before moving onto ways to rejuvenate it. In 2023, a very important study of thymus removal during cardiothoracic surgery was published, with 1146 patients undergoing thymus removal vs 1146 matched controls (mean age 55 years). The adverse outcomes for thymus removal were striking, with a 2.9 higher risk of all-cause mortality and doubling of cancer incidence, 1.5 fold increase in cancer mortality, and 1.5-fold increase in autoimmune diseases. The immune function showed marked compromise after thymus removal, as reflected by CD4+ and CD8+ T cells (Figure below) Share Ground Truths 3. Are there ways we can promote a healthy (aka rejuvenate) thymus gland in our later years? In recent months we’ve learned a lot about the process of thymus involution and the pathways by which this may be modulated. Thymus involution is primarily due to loss to thymus epithelial cells (TECs) and there are 2 subtypes with different functions: the cortical, responsible for positive selection of T cells, and the medullary, for negative selection. When adipose tissue infiltrates the thymus, thymic adipocytes are pro-inflammatory, knocking out T-cell output. Likewise, systemic inflammation, or “inflammaging,” from smoking, obesity, and chronic stress promote thymic adipocytes. Now, from preclinical studies, we know about key pathways that account for these processes. Historically, back in 2014, FOXN1 was recognized as a single master transcription factor essential for TEC function, with studies in mice with forced FOXN1 upregulation leading to thymus regeneration. That laid the foundation for potential regrowth of quiescent thymus cells. It took awhile to find pathways to accomplish this goal and to even refute its role as the master regulator. The Liver-Thymus Axis Feng Zhang and his team recently showed that injection of an mRNA vaccine to the liver encoding DLL1, IL-7 and FLT3-L in combination, factors known to support thymopoiesis (Figure), successfully enhanced immune function in aged mice. However, the effect was transient. The FGF21 Story Two reports in 2025 addressed the thymus gland’s production of FGF21, a growth factor (fibroblast growth factor 21) and its control of thymus involution. This growth factor is also produced by the liver, but it doesn’t have impact on the thymus in aged rodent models. In contrast, The liver’s hepatocyte growth factor (HGF) has been shown to reverse senescent TEC structural changes. Growth hormone stimulates production of insulin growth factor-1 (IGF-1) in the liver and the thymus. Two small studies in human participants (TRIIM, for Thymus Regeneration, Immunorestoration, and Insulin Mitigation) of 6 and 50 people, respectively, treated with combined human growth hormone, metformin and DHEA, suggested the potential of slowing epigenetic aging and improving thymus mass and function. But the combination of drugs, small sample, and lack of controls make conclusions murky. Increased thymus FGF21 led to increased CD8 T cells in old mice and extended healthspan and improved physical performance. Building on the previous FOXN1 data, ablation of β-klotho, the obligatory co-receptor for FOXN1, accelerated thymic aging. The benefit to FGF21 was confirmed in a companion paper using an FGF21 knock-in mouse model showing thymus enlargement and increased TECs throughout the lifespan. (schematic Figure below). The accompanying editorial for these 2 papers speculated: “The proposed link between age-associated thymus involution and organismal aging is intriguing, and suggests we might seek to achieve systemic rejuvenation by counteracting thymic involution.” Other Factors Lessons from the Axolotl (Mexican Salamander) In an elegant set of experiments of the axolotl (Figure), known for its complete thymus regeneration after total surgical removal, mediators were identified. Surprisingly FOXN1 was dispensable. But midkine, a growth factor, appeared to be the driver, the initiator of thymus cell growth, survival, and repair. Other components that contributed were Postn+ (periostin-expressing mesenchymal niches) and Ccl19, a chemokine protein from the bloodstream. RANK and RANKL RANK (receptor activator of nuclear factor κB its ligand (RANKL) have been considered key regulators of medullary TECs. In a study of both aged mice and human thymus cell cultures, their key role was confirmed, with multiple benefits of resorting TEC function, recruitment of progenitor cells, and T cell development. Subscribe Summing Up This body of work strongly supports the health of the thymus gland as a critical regulator of human healthspan, not just a correlate or link. The new landmark studies are reinforced by the regenerative biology experimental models that have shown, via an array of mediators, that healthspan of aged mice is at least in part dependent on thymus gland function and its critical role for maintaining adaptive immunity. It sure seems that we’d be better off having an immune reservoir of naive T cells instead of a profile in older adults of exhausted, low quality, memory T cells, with a senescent phenotype. It is striking that we ignored the importance of the thymus gland for many decades. A wake-up call was the results of the thymectomy matched control study reviewed here, with the opposite of high thymic health score improved health outcomes. The convergence of AI and healthspan here is notable. The exceptional and laborious work for developing and validating (no less explaining) the AI to quantify thymus health set the foundation for probing the connect the major health outcomes in two cohorts with extensive follow-up. We’ve never had a way to meaningfully quantify the thymus gland before, so this represents important leverage of supervised, self-supervised, and transformer models. The study wouldn’t have been possible without AI. And it begs the question as to whether there are ways we can maintain our thymus at a high health score. But it’s not so simple to rejuvenate our thymus. There are multiple risks including the induction of autoimmunity, increasing the risk of cancer, and inducing a pro-inflammatory state. For example, factors that increase TEC proliferation could compromise the medulllary negative selection process and leak out auto-reactive (self-attacking) T cells. Thymic cells could be induced to proliferate, but we know, for example, that growth hormone and IGF-1 are associated with an increase risk of cancer. If thymus rejuvenation doesn’t clear out the accumulated senescent cells in older adults, then inflammation within the gland could block the production of TECs. Keeping these risks in mind, we now have identified many ways to keep our thymus healthy as we age that undoubtedly will be tested in clinical trials going forward. Ultimately, the benefit-to-risk tradeoffs will be defined. In the meantime, we have desperately needed an immunome. As I’ve stressed in multiple prior Ground Truths, we have no test in the clinic to assess a patient’s immune status! It was very encouraging for me to get an email from Hugo Aerts, the senior author of the landmark papers in the days after they were published: “I also wanted to say that your Substack on “Why We Need an Immunome” was inspiring for this work. We found it a very compelling perspective and greatly enjoyed reading it.” Just having an assessment of a person’s immune status via a chest CT scan, with millions of these performed per year, might help in guiding the right immunotherapy for cancer (e.g. more intensive, combinations for those with low thymic health scores) and help define people who are increased risk for age-related diseases of cancer, cardiovascular, and neurodegenerative. The main theme of Super Agers is that we now have many layers of data (genetics, proteins, biomarkers, organ clocks that can be integrated via multimodal AI) for us to define a person’s specific risk decades before one of these age-related diseases leads to symptoms, enabling prevention. From the new studies this week, we can add thymus health score as yet another way to understand a person’s risk, a window into their adaptive immune system and healthspan. And perhaps someday we will be able to safely rejuvenate the thymus, or maintain its health through one’s life, and use the thymus health score to monitor. NB: I wrote this post (No A.I.) A Quick Poll Loading... ********************************************************************* Thanks to Ground Truths subscribers (now > 200,000) from every US state and 212 countries. Your subscription to these free essays and podcasts makes my work in putting them together worthwhile. Please join! If you found this interesting PLEASE share it! Share Ground Truths Paid subscriptions are voluntary and all proceeds from them go to support Scripps Research. They do allow for posting comments and questions, which I do my best to respond to. Please don’t hesitate to post comments and give me feedback. Let me know topics that you would like to see covered. Leave a comment Many thanks to those who have contributed—they have greatly helped fund our summer internship programs for the past two years. It enabled us to accept and support 47 summer interns in 2025! We aim to accept even more of the several thousand who will apply for summer 2026.
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The rationale for striking Iran was already a mess. Trump just made it worse.
The Trump administration’s stated justifications for going to war with Iran were already a jumbled and self-contradictory mess before the president’s latest comments Tuesday.
In Their Words: How Trump's and his administration's statements on Iran evolved and conflicted
President Donald Trump and his team have given shifting and sometimes conflicting reasons for striking Iran, even as they claim the mission a total success
Israel bombing vintage US-made fighter jets in Iran
Video footage shows the Israel Defense Forces striking two F-4 and F-5 fighters before they took off from an airport in western Iran.
'It's not true.' Trump's reasons for Iran attacks questioned
Donald Trump says Iran was close to developing nuclear weapons and ballistic missiles capable of striking the U.S. Analysts say that's not true.
Oversharing Can Be A Positive Form Of Communication To Reach People
Effective communication requires you to balance sharing your feelings with staying stoic. Striking the right mix takes practice.
Balancing act: Top general tries to avoid conflict with Trump while preparing for possible war with Iran
As Chairman of the Joint Chiefs Gen. Dan Caine has been drafting military options for potentially striking Iran, a steady stream of top officials from the Army, Navy and Air Force have been quietly summoned directly to his office.
Starwatch: Jupiter shines steady in Gemini
Solar system’s largest planet remains a brilliant, unwavering beacon, forming a striking trio with Castor and Pollux
Trump Considers Targeted Strike Against Iran, Followed by Larger Attack
The top negotiators plan to meet in Geneva on Thursday for last-ditch talks, debating a new proposal that could create an off-ramp as two carrier groups massed within striking distance of Iran.