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Physicists just found a tiny flaw in time itself
Physicists are rethinking one of quantum mechanics’ biggest puzzles: how fuzzy possibilities become definite reality. New research suggests that spontaneous “collapse” processes—possibly linked to gravity—could subtly blur time itself. This wouldn’t affect clocks we use today, but it reveals a hidden limit to how precise time can ever be. The findings open a new path toward uniting quantum physics with gravity.
Why International Order Still Matters
It is easier to point out the fraying of the existing international order than it is to precisely define what international order is.
Scientists Unveil ‘Long Lost’ Map for Smell
The odor receptors in the nose are not distributed at random but organized in a precise spatial pattern, two new studies reveal.
Scientists Think Time Could Move Fast and Slow All at Once. They’re About to Prove It.
Ultraprecise atomic clocks could test the idea that time moves at multiple speeds.
MIT researchers find self-organizing “pencil beam” laser could help scientists design brain-targeted therapies
After a surprising discovery that overcomes a longstanding problem in fiber optics, MIT researchers demonstrated a biomedical imaging technique that is faster and more precise than other methods, which could help scientists and clinicians study new brain therapies.
AI just discovered new physics in the fourth state of matter
Physicists have taken a major step toward using AI not just to analyze data, but to uncover entirely new laws of nature. By combining a specially designed neural network with precise 3D tracking of particles in a dusty plasma—a strange “fourth state of matter” found from space to wildfires—the team revealed hidden patterns in how particles interact. Their model captured complex, one-way (non-reciprocal) forces with over 99% accuracy and even overturned long-held assumptions about how these forces behave.
The Universe Is Expanding Too Fast and Scientists Can’t Explain Why
The most precise measurement yet shows the Universe is expanding faster than expected, deepening the Hubble tension. The result hints that something may be missing from our current understanding of the cosmos.
How can scientists visualize cellular life with greater precision? - Salk Institute for Biological Studies
Highlights Salk researchers collaborated with scientists at Albert Einstein College of Medicine to develop a new class of probes for imaging living cells The probes, called visible-spectrum antigen-stabilizable fluorescent nanobodies (VIS-Fbs), generate high-contrast images with minimal disruption to normal cellular activity The technology enables more precise investigation of complex biological processes, including cell signaling, development, and disease progression LA JOLLA—Fluorescent proteins have revolutionized science, enabling researchers to tag and visualize individual molecules in living cells, tissues, and animals. Using these tools, researchers have watched viruses infect cells in real time, observed cellular trash collection, and tracked the signaling that spurs tumor growth.
ARPA-H announces first research teams for $139 million initiative to transform behavioral health and bring new, more precise and effective treatments to Americans
The EVIDENT initiative builds on the Trump Administration’s executive order to accelerate medical treatments for serious mental illness.
Shaky political science: using "simulated" elections over real-world elections
[Dear DSOS readers – this article is the latest in our “Shaky Political Science” series. In our 38 page report, “Shaky political ‘science’ misses mark on ranked choice voting,” released in early December, we examined over 40 studies focused on ranked choice voting. We found that many of these studies suffered from puzzling research methodologies, poorly constructed surveys, unrealistic simulated elections, cherry picked data, and faulty analyses that often were contradicted by results from real-world elections (a link to our full paper is here). Here are links to the first three articles in our series: the first one summarizing the overall results of our report, the second one analyzing a study co-authored by University of Minnesota academic Larry Jacobs, which was one of the most error-prone of all the research we reviewed in our report, and a third article showing an admirable example of two political scientists holding two other political scientists accountable for their flawed, sloppy research]. In this fourth article in our “Shaky Political Science” series, we shine a spotlight on seven studies that were web-hosted and funded by New America’s Political Reform Program and its Electoral Reform Research Group (the ERRG is an ad hoc committee headed by New America’s Political Reform Program and joined by the American Enterprise Institute, the Unite America Institute and Stanford University’s Center on Democracy, Development, and the Rule of Law). This research consortium has been led by Lee Drutman, senior fellow with New America’s Political Reform Program. These seven studies are simply not credible from any objective standard about how political “science” is supposed to illuminate our understanding of either ranked choice voting or politics in general. The feature that six of these seven studies have in common is that they all used surveys – artificial, simulated elections -- to attempt to say something cogent or interesting about ranked choice voting (RCV) elections. None of them used real world data from actual RCV elections – either the 1000+ elections in the US or the many thousands of elections from places like Australia, Ireland and elsewhere where RCV has been used for 100 years. While a few of these studies conclude with some mixed positives about RCV, our analysis here is content neutral. The idea that, with a political reform like RCV, you can ask respondents in a mock, artificial election to vote with that method, with only the barest of explanation about how RCV works or its likely impacts (i.e. no spoiler candidates, majority winners, voters liberated to pick their favorite candidates, coalition-building), and then ask them their thoughts/reactions about voting in that system, with fake candidates and no real campaigning, no real exposure to an actual election or actual candidates, rests on some very puzzling assumptions. The findings of these seven studies actually are contradicted by the findings from many other studies based on real-world RCV elections. These New America studies also failed to list the real-world RCV studies in their own citations, instead including those studies that reinforced their conclusions. The seven studies featured in this article were chosen because they form a cohesive cohort which precisely illustrates one of the main points of our research paper, namely that using surveys, i.e. artificial elections, or mathematical/theoretical models, instead of real-world data, is in fact “shaky political science.” Below are summaries of our analysis of five of the seven New America studies. You can read our complete analysis of all seven studies at our paper, “Shaky political ‘science’ misses mark on ranked choice voting.” Choosing to “Vote As Usual” by Andre Blais, Carolina Plescia, and Semra Sevi. New America. (Blais et al., 2021). This study, web-hosted and funded by New America’s Political Reform Program and its Electoral Reform Research Group, used two surveys in which respondents completed ballots for simulated elections using plurality, approval, RCV and point (Score) voting. In both cases the authors provided the respondents with only minimal explanation of each method. For example, the entire explanation for RCV was “For this vote, rank the candidates from your first to your last choice (you do not need to rank them all). This is called the ranked vote.” That’s it. The study did not provide any context or explanation to survey respondents about why she/he might want to rank multiple candidates. Participants were not even told that ballots would be tabulated using an “instant” runoff, not to mention any description of RCVs ability to eliminate the spoiler effect or liberate voters to rank their favorite candidates without fear of helping the “greater evil” candidate to win. That’s like taking an iPhone back in time to 1970 and asking someone if they like it better than their rotary phone without explaining how it works. Their first survey targeted states that held 2020 Super Tuesday Democratic primaries and used the real candidates’ names in the survey; the second survey used fictitious candidates. In other words, they surveyed respondents who had only ever participated in plurality elections, had no history or background with using RCV or any of the other methods, had no clue about its likely impacts, and did not communicate how the alternative methods would be counted, and then asked them: “How satisfied are you with using each system?” Predictably, the winner was plurality elections, the system used for president, Congress, gubernatorial and state legislative elections – in other words, the method they have been using, year after year, all their voting lives. With so little explanation of RCV and its impacts, this study is simply not credible in discovering anything useful about real-world RCV elections. It merely shows that a basic voter education campaign is needed when adopting a new election system. Additionally, the result contradicts many other post-election surveys following real RCV elections, asking opinions from voters who had just participated in a RCV election, that showed a great deal of satisfaction with RCV (see details on that in Studies 22-25 in our paper, as well as the four studies cited in the review for Study 28). Share Other studies on “satisfaction” and “understanding” make similar mistakes, in terms of basing their surveys on inadequate explanation to respondents and lack of education about context. How could any survey ever hope to measure accurately, in essence simulate a real-world election, without actual campaigning candidates, the media writing about those candidates, organizations endorsing candidates and voters being inundated with crucial information? More than anything, what these “studies” based on surveys show is that if you ask voters about something they don’t know very much about, and fail to adequately educate them, their responses will unsurprisingly reflect their confusion. Equally puzzling is that New America’s Electoral Reform Research Group, headed by political scientist Lee Drutman, found this to be a credible enough study that they not only published it but highlighted it in Drutman’s own discussion of research related to ranked choice voting. This pattern was repeated in study after study featured by New America’s Electoral Reform Research Group. For example in Ranked-Choice Voting and Political Expression: Voter Guides Narrow the Gap between Informed and Uninformed Citizens by Cheryl Boudreau, Jonathan Colner, and Scott MacKenzie, the researchers based their analysis on a survey which found that respondents who were asked to vote in a simulated RCV election, with minimal explanation of RCV or how it works, displayed less evidence of being informed about how to use RCV effectively, with the least informed voters ranking fewer candidates. As pointed out under the study above, in a real election voters are informed by a wide variety of methods, including public education by the election administration, by interested political groups, the media, and the candidates themselves who benefit from voters being aware of how to vote in the new system. In Support for Ranked-Choice Voting across Race and Partisanship by Joseph Anthony, David C. Kimball, Jack Santucci and Jamil Scott, the researchers used respondents from different parties and races voting in simulated plurality and RCV elections, who indicated their satisfaction with each voting method. Instead of using real world election results, the authors fell back on the easy, armchair and less reliable academic research methodology of making up mock elections. As with the other studies, little explanation was given of how RCV works or what its implications might be (electing majority winners or eliminating spoilers, for example). Unsurprisingly, this study found that respondents were not very satisfied with RCV. However, when the authors added an explanation that RCV has a tendency to elect more women and people of color, they found that this greater explanation increased the preference for RCV. The more voters were familiar with it, and the more they understood potential positive impacts – surprise! -- the more they were open to switching away from the status quo. Of note, the results from this study are thoroughly contradicted by a number of other studies whose data was obtained from real RCV elections with real voters. Those studies show a great deal of satisfaction with RCV. More “fake election” research An interesting wrinkle on this “research by fake elections” approach, which only served to illustrate how unreliable such “research” can become, was taken in Ranked-Choice Voting, Runoff, and Democracy: Insights from Maine and Other U.S. States by Joseph Cerrone and Cynthia McClintock_,_ also web-hosted and funded by New America’s ERRG. It gets high marks for creativity, but an eye-roll for thinking this could possibly add anything meaningful to our understanding of real world RCV elections. This study tried to determine whether RCV, plurality or two-round runoff elections provided greater voter satisfaction and acceptance of election results. To determine that, the authors conducted a survey asking if voters were satisfied with a fictional newspaper report of an election, with three different versions given to respondents – plurality, runoff and RCV, with variations of Republican/Democrat winners and variations of “come-from-behind” winners,” i.e. candidates not initially in first place but who win the “runoff.” Again, a minimal explanation of RCV or how it works was given, and the survey showed that respondents had the greatest unfamiliarity with RCV than the other methods. The unsurprising result? Respondents were much more satisfied with “come-from-behind” victories in a traditional two-round runoff election than in RCV, even though RCV is also a runoff system but with a single round of counting. Interestingly, the dissatisfaction with RCV disappeared for those who were more familiar with RCV. In fact, among those respondents who were “very familiar” with RCV, they were equally satisfied with RCV, runoff and plurality. Surprise, surprise. Again, what this study revealed, more than anything, is not only the inadequacy of the explanation for RCV given by the authors of this study, but the failure of the research format itself, thinking that such an artificial mock election could somehow simulate what actually happens in the real world in a real RCV election. Those four studies reviewed above are fitting examples of inadequate and shaky political “science.” Other studies reviewed in our paper from the New America/Electoral Reform Research Group cohort which also used mock elections included: Ranked-Choice Voting is an Acquired Taste by Joseph Anthony and David C. Kimball. New America. (Anthony et al., 2021). Ranked-Choice Voting is No Refuge for Extreme Candidates by Melissa Baker. New America. (Baker, 2021). Also included in this New America cohort is Does Ranked-Choice Voting Reduce Racial Polarization? by Yuki Atsusaka and Theodore Landsman, which actually did use real-world election results data but applied an odd and unconventional methodology to the data which relied on shaky assumptions and non-real-world scenarios that were too divorced from reality. To determine levels of “racially polarized voting,” the researchers imagined “ethnic parties,” by which they mean political parties for each ethnic group, which was especially odd since the election data they were using came from nonpartisan RCV races. But then they made an even odder assumption, namely that since race and ethnic characteristics of studied voters were not available, the authors tried to infer that information based on who voters selected and the racial make-up of voters in each district. This amounted to little more than vague and ambiguous guesswork dressed up with a bunch of mathematical equations used to give it a veneer of scientific appearance. Indeed, it seemed to assume racial polarization in order to prove racial polarization. Based on this questionable methodology, the authors concluded that RCV doesn’t reduce racial polarization. But the premise of this study missed an obvious reality: since RCV incentivizes more candidates to run and can result in more diverse fields of candidates, one would expect more racially-polarized voting in voters’ top rankings, not less, because more voters would have someone on that ballot who represents their racial or ethnic identity and more freedom to vote for their real first choice. By encouraging more diverse candidates and eliminating the spoiler effect, RCV facilitates voting for a favorite candidate of your own race and then selecting a second choice with the best likelihood of winning. The real measure is what voters do with their additional rankings – do they consider other candidates and vote “for the best of the rest”? This study didn’t tell us anything useful about that. But readily available data shows this is common in real RCV elections, and candidates act on this knowledge by engaging with voters outside their racial group. So the authors of this study failed to consider or account for what actually happens in real-world elections, and their conclusions are tainted by this failure. New America has contributed a great deal over the past 2.5 decades to our understanding of many policy areas, including politics and political reform (full disclosure: Steven Hill, one of the authors of this article and of the “Shaky Political Science” research paper and series, is a former senior fellow and former director of New America’s political reform program, 2005-2010). So it was especially disappointing that New America funded and published such a large batch of dubious studies about ranked choice voting. The stated praiseworthy goal of its Electoral Reform Research Group was to inspire new academic research about ranked choice voting that would shed light and help the public better understand the impacts of RCV. Instead, the ERRG research did just the opposite. It produced dubious research that created more confusion and misinformation. In so doing, New America’s political reform program contributed to “shaky political science.” Steven Hill and Paul Haughey Share Upgrade to $5 subscription Thanks for reading DemocracySOS, a reader-supported digital portal for the pro-democracy movement. Subscribe for only $5 per month to receive full benefits and to support our work. Subscribe
Is Science the Last Bastion of Sanity?
As we look forward to landing on the moon in 2028, we cannot afford to miss a golden opportunity to enhance the humanities precisely through science.
Using atomic nuclei could allow scientists to read time more precisely than ever
Most clocks, from wristwatches to the systems that run GPS and the internet, work by tracking regular, repeating motions.
International Collaboration Helps Pinpoint Universe’s Expansion Rate
The universe is expanding, but the exact speed at which it’s doing so – a figure known as the “Hubble constant” – remains a mystery. Now, an international collaboration of astronomers has developed a framework that incorporates a range of methods into one analysis, to produce a more precise measurement.
How aggressive breast cancer turns off the immune system
Researchers are launching a new project to crack the mystery of aggressive breast cancer, where predicting disease progression remains a major hurdle. By studying how tumors interact with and suppress the immune system, scientists aim to identify new biomarkers that reveal how the cancer evolves. Using real patient samples, the team hopes to turn earlier discoveries into practical clinical tools. The goal: more precise, personalized treatments that can outsmart even the most dangerous tumors.
The Universe is expanding too fast and scientists still can’t explain it
A major international effort has produced an ultra-precise measurement of the Universe’s expansion rate, confirming it’s faster than early-Universe models predict. By linking multiple distance-measuring techniques, scientists ruled out simple errors as the cause of the discrepancy. The persistent “Hubble tension” now looks more real than ever. It could mean our current model of the cosmos is incomplete.
Physicists moved volatile antimatter by truck for the first time ever — paving the way for groundbreaking new research
CERN scientists transported antimatter by truck for the first time, enabling ultraprecise studies that could reveal why matter dominates the universe.
MXene breakthrough boosts conductivity 160x with perfect atomic order
A new breakthrough is transforming MXenes—ultra-thin, high-tech materials—into something far more powerful and precise. Researchers have developed a cleaner, more controlled way to build these materials using molten salts and iodine, eliminating the messy chemical processes that once left their surfaces disordered. The result is a perfectly arranged atomic structure that lets electrons flow with remarkable ease, boosting conductivity by up to 160 times.
Scientists say BMI gets it wrong for over one third of adults
A new study suggests that one of the most widely used health metrics, BMI, may be getting it wrong for a large portion of the population. By comparing BMI classifications with precise body fat measurements using advanced DXA scans, researchers found that more than one-third of adults were placed in incorrect weight categories. Many people labeled as overweight or obese did not actually have the corresponding body fat levels, while others were missed entirely.
‘Change the terrain’ for deliberative democracy
Vince Bzdek’s Gazette piece on James Fishkin’s experiments in deliberative democracy is an interesting read, though the very factors that produced its results — balanced information, expert moderation, and structured discussion — are what everyday politics lacks, and precisely what make these experiments so difficult to scale (“Can deliberation save democracy?” March 8). The processes […]
Stanford scientists create shape-shifting material that changes color and texture like an octopus
A new shape-shifting material can change both its texture and color in seconds, inspired by the camouflage abilities of octopuses. By precisely controlling how a polymer swells with water, researchers can create detailed, reversible patterns at the nanoscale. The material can even mimic realistic surfaces and dynamically adjust how it reflects light. In the future, AI could allow it to automatically blend into its surroundings.
This new “phonon laser” could measure gravity more precisely than ever before
Scientists have taken lasers beyond light and into the realm of sound, creating a breakthrough “phonon laser” that manipulates tiny vibrations at the quantum level. By dramatically reducing noise in these systems, researchers can now measure motion and forces with unprecedented precision. This advance could unlock new ways to study gravity, probe quantum physics, and even revolutionize navigation with ultra-accurate, satellite-free systems.
Day in the life of Liz Plosser; former Women's Health editor-in-chief
Liz Plosser, the former editor-in-chief of Women's Health, starts her day with a precise alarm and has a tinned fish wrap for lunch every afternoon.
Your Thymus and Your Healthspan
Our thymus gland plays a central role in the development or our immune system, specifically for supporting T cell development (how these cells got their name, maturation and differentiation in the thymus) and discriminating between self and foreign, non-self antigen proteins with production of dendritic cells. As we age, our thymus gland shrinks—the process known as involution—with progressive change from spongy to fatty tissue, with loss of functionality. But this process, with respect to timeline and extent, markedly varies from one person to the next. And to make things even more complicated, our thymus gland anatomy and precise location in the chest also is highly variable. So the famous Frank Netter diagrams from the 1960s (such as at left below) don’t capture the remarkable heterogeneity that a random set of 12 chest CT scans (below at right). What I consider as 2 landmark papers in Nature this week (here and here) used AI to quantify health of the thymus in 2 large cohorts, and then correlate the metric to a broad array of health outcomes. In this edition of Ground Truths, I’m going to cover three questions: (1) How was thymus health determined by AI?; (2) How is thymus health linked to key clinical outcomes? and (3) Are there ways we can promote a healthy (aka rejuvenate) thymus gland in our later years? Subscribe 1. How was thymus health determined by AI? This was accomplished by extensive work developing and validating an AI pipeline for 2 stages, the first for localization and segmentation of the thymus bed, and the second to quantify a digital marker, termed the thymic health score. There’s a lot to this algorithmic development, so I won’t go into all the details, but just provide a rudimentary outline of what was done. The 1st stage used supervised learning with 2 radiologists reviewing 2,461 chest CT scans. That work trained a 3D U-Net model to automatically identify the thymic bed’s 3D cropped region using center of mass coordinates, which reached 99.8% accuracy. The 2nd stage used a foundation model that was pre-trained with SwAV (which stands for Swapping Assignment between multiple Views), a self-supervised model, that generated a high-dimensional thymus representation of 4,096 features. That compares to the radiology reductionist and subjective scoring of 0 to 3 where 0 means the thymus is fully degenerated and fatty, and 3 is considered dense, intact glandular soft tissue. Notably, the self-supervised learning (SSL) performance was superior to supervised (AUC ~0.75 vs 0.55, respectively) reflecting the shallowness of the 0-3 classifier vs SSL’s holistic, self-taught AI. The thymic health score ranged from 0 to 100, with the highest number indexed to fully preserved thymic health. The algorithmic work extended to explainability with both Shapely value distribution, meaning the model was holistic not relying on any “magic” pixel, and occlusion sensitivity, demonstrating the model’s performance was not affected by ribs, sternum, lung tissue, but rather focused on the thymic bed directly. Below are a few saliency maps from the occlusion sensitivity that indicate the thymic bed focus, not affected by neighboring structures, using the jet color scale. Now the AI was ready for processing ~25,000 CT scans, each over 30 MB files, from the 2 large participant cohorts to provide a thymic health score, it did so in less than 14 hours, which is less than 2 seconds per scan! Share 2. How is thymus health linked to key clinical outcomes? The two cohorts were the National Lung Screening Trial, NLST (N=25,031) and the Framingham Heart Study, FHS (N=2,581) each with baseline demographics and long term follow up of >12 years for health outcomes. From the NSLT, you can see below that increased age and body-mass index were correlated to reduced thymic health. And, overall, men had reduced thymic health scores compared with women. There are a lot of graphs in the paper for outcomes, for both the NLST and FHS cohorts. To simplify the major outcomes, below is a composite Figure with striking reduction of all-cause mortality and for the different causes of death. The results were consistent between the 2 cohorts. For example, the cardiovascular mortality hazard ratio average was 0.57 in NLST and 0.38 in FHS (weighted to be 0.53 for the aggregate). The reduction of mortality also extended to digestive diseases and pulmonary disease (data not shown below). Lung cancer incidence was reduced by 36% for high vs low thymic health (Figure below, with a panel -incidence and b panel-mortality, adjusted for age, sex, BMI, smoking status). Notably, there was a smoker’s paradox: lower incidence and improved survival for lung cancer in smokers who had a high thymus health score. Smoking was associated with lower thymic scores whereas alcohol was not. Higher thymic health was linked to higher HDL cholesterol, lower triglycerides, lower fasting blood glucose, and lower systolic and diastolic blood pressure. Inflammation biomarkers, such as C-reactive protein and interleukin-6, were elevated in the people with lower thymic health scores. In their second paper, the same team looked at the relationship between thymic score and outcomes for 3,476 patients receiving cancer immunotherapy. The non-small cell lung cancer progression-free survival was reduced in patients with low thymic health score. A parallel relationship for survival was seen for other types of cancer including melanoma, breast, and kidney with a 44% lower risk among high thymic scores (Figure). A similar pattern was seen with different immune checkpoint inhibitors. The thymus health score outperformed programmed death ligand-1 (PD-L1)and tumor mutation burden (TMB) assay of the tumor and was an independent prognostic marker of progression-free survival. In this dataset, a direct connect with thymus score and adaptive immune function was noted with a correlation before cancer treatment for both T-cell diversity and thymus T-cell production (a metric known as T cell receptor excision circles). Thymus Removal Study There is a highly relevant citation about thymus function before moving onto ways to rejuvenate it. In 2023, a very important study of thymus removal during cardiothoracic surgery was published, with 1146 patients undergoing thymus removal vs 1146 matched controls (mean age 55 years). The adverse outcomes for thymus removal were striking, with a 2.9 higher risk of all-cause mortality and doubling of cancer incidence, 1.5 fold increase in cancer mortality, and 1.5-fold increase in autoimmune diseases. The immune function showed marked compromise after thymus removal, as reflected by CD4+ and CD8+ T cells (Figure below) Share Ground Truths 3. Are there ways we can promote a healthy (aka rejuvenate) thymus gland in our later years? In recent months we’ve learned a lot about the process of thymus involution and the pathways by which this may be modulated. Thymus involution is primarily due to loss to thymus epithelial cells (TECs) and there are 2 subtypes with different functions: the cortical, responsible for positive selection of T cells, and the medullary, for negative selection. When adipose tissue infiltrates the thymus, thymic adipocytes are pro-inflammatory, knocking out T-cell output. Likewise, systemic inflammation, or “inflammaging,” from smoking, obesity, and chronic stress promote thymic adipocytes. Now, from preclinical studies, we know about key pathways that account for these processes. Historically, back in 2014, FOXN1 was recognized as a single master transcription factor essential for TEC function, with studies in mice with forced FOXN1 upregulation leading to thymus regeneration. That laid the foundation for potential regrowth of quiescent thymus cells. It took awhile to find pathways to accomplish this goal and to even refute its role as the master regulator. The Liver-Thymus Axis Feng Zhang and his team recently showed that injection of an mRNA vaccine to the liver encoding DLL1, IL-7 and FLT3-L in combination, factors known to support thymopoiesis (Figure), successfully enhanced immune function in aged mice. However, the effect was transient. The FGF21 Story Two reports in 2025 addressed the thymus gland’s production of FGF21, a growth factor (fibroblast growth factor 21) and its control of thymus involution. This growth factor is also produced by the liver, but it doesn’t have impact on the thymus in aged rodent models. In contrast, The liver’s hepatocyte growth factor (HGF) has been shown to reverse senescent TEC structural changes. Growth hormone stimulates production of insulin growth factor-1 (IGF-1) in the liver and the thymus. Two small studies in human participants (TRIIM, for Thymus Regeneration, Immunorestoration, and Insulin Mitigation) of 6 and 50 people, respectively, treated with combined human growth hormone, metformin and DHEA, suggested the potential of slowing epigenetic aging and improving thymus mass and function. But the combination of drugs, small sample, and lack of controls make conclusions murky. Increased thymus FGF21 led to increased CD8 T cells in old mice and extended healthspan and improved physical performance. Building on the previous FOXN1 data, ablation of β-klotho, the obligatory co-receptor for FOXN1, accelerated thymic aging. The benefit to FGF21 was confirmed in a companion paper using an FGF21 knock-in mouse model showing thymus enlargement and increased TECs throughout the lifespan. (schematic Figure below). The accompanying editorial for these 2 papers speculated: “The proposed link between age-associated thymus involution and organismal aging is intriguing, and suggests we might seek to achieve systemic rejuvenation by counteracting thymic involution.” Other Factors Lessons from the Axolotl (Mexican Salamander) In an elegant set of experiments of the axolotl (Figure), known for its complete thymus regeneration after total surgical removal, mediators were identified. Surprisingly FOXN1 was dispensable. But midkine, a growth factor, appeared to be the driver, the initiator of thymus cell growth, survival, and repair. Other components that contributed were Postn+ (periostin-expressing mesenchymal niches) and Ccl19, a chemokine protein from the bloodstream. RANK and RANKL RANK (receptor activator of nuclear factor κB its ligand (RANKL) have been considered key regulators of medullary TECs. In a study of both aged mice and human thymus cell cultures, their key role was confirmed, with multiple benefits of resorting TEC function, recruitment of progenitor cells, and T cell development. Subscribe Summing Up This body of work strongly supports the health of the thymus gland as a critical regulator of human healthspan, not just a correlate or link. The new landmark studies are reinforced by the regenerative biology experimental models that have shown, via an array of mediators, that healthspan of aged mice is at least in part dependent on thymus gland function and its critical role for maintaining adaptive immunity. It sure seems that we’d be better off having an immune reservoir of naive T cells instead of a profile in older adults of exhausted, low quality, memory T cells, with a senescent phenotype. It is striking that we ignored the importance of the thymus gland for many decades. A wake-up call was the results of the thymectomy matched control study reviewed here, with the opposite of high thymic health score improved health outcomes. The convergence of AI and healthspan here is notable. The exceptional and laborious work for developing and validating (no less explaining) the AI to quantify thymus health set the foundation for probing the connect the major health outcomes in two cohorts with extensive follow-up. We’ve never had a way to meaningfully quantify the thymus gland before, so this represents important leverage of supervised, self-supervised, and transformer models. The study wouldn’t have been possible without AI. And it begs the question as to whether there are ways we can maintain our thymus at a high health score. But it’s not so simple to rejuvenate our thymus. There are multiple risks including the induction of autoimmunity, increasing the risk of cancer, and inducing a pro-inflammatory state. For example, factors that increase TEC proliferation could compromise the medulllary negative selection process and leak out auto-reactive (self-attacking) T cells. Thymic cells could be induced to proliferate, but we know, for example, that growth hormone and IGF-1 are associated with an increase risk of cancer. If thymus rejuvenation doesn’t clear out the accumulated senescent cells in older adults, then inflammation within the gland could block the production of TECs. Keeping these risks in mind, we now have identified many ways to keep our thymus healthy as we age that undoubtedly will be tested in clinical trials going forward. Ultimately, the benefit-to-risk tradeoffs will be defined. In the meantime, we have desperately needed an immunome. As I’ve stressed in multiple prior Ground Truths, we have no test in the clinic to assess a patient’s immune status! It was very encouraging for me to get an email from Hugo Aerts, the senior author of the landmark papers in the days after they were published: “I also wanted to say that your Substack on “Why We Need an Immunome” was inspiring for this work. We found it a very compelling perspective and greatly enjoyed reading it.” Just having an assessment of a person’s immune status via a chest CT scan, with millions of these performed per year, might help in guiding the right immunotherapy for cancer (e.g. more intensive, combinations for those with low thymic health scores) and help define people who are increased risk for age-related diseases of cancer, cardiovascular, and neurodegenerative. The main theme of Super Agers is that we now have many layers of data (genetics, proteins, biomarkers, organ clocks that can be integrated via multimodal AI) for us to define a person’s specific risk decades before one of these age-related diseases leads to symptoms, enabling prevention. From the new studies this week, we can add thymus health score as yet another way to understand a person’s risk, a window into their adaptive immune system and healthspan. And perhaps someday we will be able to safely rejuvenate the thymus, or maintain its health through one’s life, and use the thymus health score to monitor. NB: I wrote this post (No A.I.) A Quick Poll Loading... ********************************************************************* Thanks to Ground Truths subscribers (now > 200,000) from every US state and 212 countries. Your subscription to these free essays and podcasts makes my work in putting them together worthwhile. Please join! If you found this interesting PLEASE share it! Share Ground Truths Paid subscriptions are voluntary and all proceeds from them go to support Scripps Research. They do allow for posting comments and questions, which I do my best to respond to. Please don’t hesitate to post comments and give me feedback. Let me know topics that you would like to see covered. Leave a comment Many thanks to those who have contributed—they have greatly helped fund our summer internship programs for the past two years. It enabled us to accept and support 47 summer interns in 2025! We aim to accept even more of the several thousand who will apply for summer 2026.
“Loyal Slaves” and Campfire Entertainment in Frank Vizetelly’s Confederate Camp
Frank Vizetelly’s illustration titled “Night Amusements in the Confederate Camp” appeared in the Illustrated London News on January 10, 1863. It was one among a number of wartime scenes that Vizetelly captured for the newspaper. Subscribe Following the war, the illustration appeared in a number of books, including John O. Casler’s Four Years in the Stonewall Brigade (1893) and Campfires of the Confederacy (1898) by Ben La Bree. The scene depicts a Confederate camp at night with an enslaved man, most likely a camp servant, performing a dance around a fire with the music provided by a soldier playing a banjo. Another enslaved man looks on at the right. Vizetelly likely witnessed the scene—one that would have been common throughout the war. It’s a wonderful example of the way in which Confederates—slaveowners and nonslaveowners alike—experienced the presence of slave labor in the army. Vizetelly was deeply sympathetic to the Confederate cause. His depiction of the enslaved man as more than happy to entertain the very people who were fighting to keep him enslaved was precisely the kind of image designed to reassure a British audience that slavery was benign, and by implication, that Britain need not feel morally troubled about recognizing or supporting the Confederacy. Share Just as importantly, the sight of a dancing slave reassured Confederates themselves that the institution of slavery remained secure even after President Lincoln signed the Emancipation Proclamation. I’ve come across this illustration many times before and I plan on using it in my next book project on the role of enslaved labor in the Confederate army during the Gettysburg Campaign, but this is not the reason I am sharing it with you today. It has to do with where I recently found it, which came as a complete surprise and is incredibly revealing. Let’s take a look.
Chinese scientists create clock so precise it could redefine second
Optical clock measures time using light emitted by electrons transitioning between energy levels
At the Winter Paralympics, some athletes have found business opportunities
At the Winter Paralympics, athletes with prosthetics often modify them to fit their bodies more precisely. That has led to some competitors starting their own businesses to help fellow amputees.
At the Winter Paralympics, some athletes have found business opportunities
At the Winter Paralympics, athletes with prosthetics often modify them to fit their bodies more precisely. That has led to some competitors starting their own businesses to help fellow amputees.
Scientists control 'free-flowing' electric currents with light
By controlling magnetic fields using light, a team of researchers led by NTU scientists has solved a long-standing challenge to precisely direct electric currents produced by quantum materials. Their ...
Nordic Semiconductor introduces precise, adaptive battery health-monitoring to enable smarter, longer-lasting IoT devices
Nordic Semiconductor, a global leader in low-power wireless connectivity solutions, today announces Nordic Fuel Gauge v2.0, a major upgrade of its highly accurate software-based fuel gauge solution for the award-winning nPM1300, and nPM1304 Power Management ICS, at Embedded World 2026. The release adds sophisticated State-of-Health estimation, adaptive battery modeling, and long-term fleet analytics capabilities, extending advanced battery management to a wide range of power-constrained IoT prod
Why presidents stumble in this most solemn task
After ordering US troops to execute a regime change in Panama in 1989, President George H.W. Bush held a press conference at the precise moment the first US casualties were arriving on US soil.
3L Kevin Afiesh Learns to Translate Legal Risk Into Business Strategy as FinTech Extern - UC Law San Francisco (Formerly UC Hastings)
3L Kevin Afiesh strengthened his corporate and fintech skillset through an externship at Plaid, gaining real-world experience at the intersection of technology and financial services. 3L student Kevin Afiesh shares how UC Law San Francisco’s Corporate Counsel Externship provided immersive, practice-ready training inside Plaid’s in-house legal department. Reviewed and analyzed technology-focused agreements, including emerging AI provisions and liability terms Explored financial services regulation and data governance within a growth-stage company Learned how internal legal teams shape product, partnership, and compliance planning 3L student Kevin Afiesh: During my externship at Plaid, I worked with the in-house legal team supporting a rapidly growing company at the intersection of technology and financial services. My work focused primarily on corporate, commercial, and intellectual property matters. I helped review and analyze vendor and partnership agreements, paying close attention to emerging artificial intelligence-related provisions and risk allocation terms. I also investigated regulatory and compliance issues involving financial services and data governance, and I researched intellectual property litigation relevant to fintech companies. This work supported legal risk assessment to guide strategic decision making. I learned firsthand how an in-house legal team operates in a highly regulated, innovation-driven environment, where legal analysis is closely integrated with business decision making. I saw how attorneys balance legal risk with commercial priorities and how their advice shapes contracting, compliance, and intellectual property strategy. It reinforced that effective in-house lawyers need to understand both the law and the operational realities of the business. The experience also strengthened my ability to communicate complex legal concepts clearly to non-lawyers and to provide advice that is precise, practical, and commercially aware. Throughout my academic and professional journey, I’ve worked with technology companies at different stages. Plaid added a distinct perspective within the tech ecosystem, showing me how a growth-stage fintech company approaches regulatory complexity, innovation, and risk tolerance. This sharpened my ability to adapt to clients with different structures, priorities, and compliance needs. As I prepare to practice corporate law in the technology industry, this exposure has strengthened my ability to align legal advice with a company’s stage of growth, strategic objectives, and internal dynamics. I would absolutely recommend the Corporate Counsel Externship Program. Working directly with an in-house legal team provided a meaningful sense of day-to-day practice inside a technology company, and the attorneys at Plaid were generous with their time and mentorship. The classroom component was equally valuable. Professors Nira Geevargis and Scott Darling created a thoughtful environment where we reflected on our experiences, discussed real-world challenges, and developed practical skills that complemented our fieldwork. More broadly, UC Law San Francisco’s location offers a clear advantage for students interested in technology, corporate practice, and public-interest work. Proximity to courts, law firms, and innovative companies — combined with programs like the Corporate Counsel Externship and an extensive Bay Area alumni network — make it a strong option for students who want to build their careers in the region. The Evidence of Success series highlights UC Law SF students as they share how the college’s opportunities equip them with the experience, skills, and confidence to excel in the legal profession.
Scientists capture a magnetic flip in 140 trillionths of a second
Scientists at the University of Tokyo have captured something never seen before: a frame-by-frame view of how electron spins flip inside an antiferromagnet, a material once thought to be magnetically “invisible.” By firing ultrafast electrical pulses into a thin layer of manganese–tin and tracking the response with precisely timed flashes of light, the team uncovered two distinct switching mechanisms. One relies on heat generated by strong currents, while the other flips spins directly with minimal heating — a far more efficient process.
The hidden technology that could unlock commercial fusion power
Fusion energy may be one of the most promising clean power sources of the future—but only if scientists can precisely measure the extreme, fast-moving plasmas that make it possible. A new U.S. Department of Energy–sponsored report urges major investment in advanced diagnostic tools—the high-tech “sensors” that track plasma temperature, density, and behavior inside fusion systems. Bringing together 70 experts from universities, national labs, and private industry, the workshop identified seven priority areas ranging from burning plasma to full-scale pilot plants.
For the first time, light mimics a Nobel Prize quantum effect
Scientists have pulled off a feat long considered out of reach: getting light to mimic the famous quantum Hall effect. In their experiment, photons drift sideways in perfectly defined, quantized steps—just like electrons do in powerful magnetic fields. Because these steps depend only on nature’s fundamental constants, they could become a new gold standard for ultra-precise measurements. The discovery also hints at tougher, more reliable quantum photonic technologies.
Your morning coffee could one day help fight cancer
Scientists at Texas A&M are turning an everyday pick-me-up into a high-tech medical switch. By combining caffeine with CRISPR gene editing, researchers have created a system that allows cells to be programmed in advance — and then activated simply by consuming a small dose of caffeine from coffee, chocolate, or soda. The approach, known as chemogenetics, lets scientists precisely turn gene-editing activity on and off inside targeted cells, including powerful immune T cells that can fight cancer.
Colorado is turning its back on agriculture
Colorado’s farmers and ranchers already face significant challenges, including volatile commodity prices, rising input costs, labor shortages and unpredictable weather. They should not also have to contend with a state legislature that increasingly seeks to regulate how they protect crops and livestock. Yet that is precisely what Senate Bills 26-062 and 26-065 represent: a top-down […]
Five Berkeley Lab Scientists Receive DOE Early Career Research Awards
Five scientists from Lawrence Berkeley National Laboratory (Berkeley Lab) have received Early Career Research Program (ECRP) awards from the Department of Energy. The ECRP program, now in its 16th year, was established to bolster the nation’s scientific workforce by supporting exceptional researchers at the outset of their careers, when many scientists do their most formative work. Recipients use the funding to pursue projects that have the potential to solve scientific challenges and advance the country’s STEM capabilities. To be eligible for the program, a researcher must be an untenured, tenure-track assistant or associate professor at a U.S. academic institution, or a full-time employee at a DOE national laboratory or Office of Science user facility, who is within 10 years of having earned their doctorate. Awards to an institution of higher education will be approximately $875,000 over five years, and awards to a DOE national laboratory or Office of Science user facility will be approximately $2,750,000 over five years. This year’s Berkeley Lab awardees and their projects are listed below: Timon Heim: Better detectors for more powerful particle colliders Timon Heim is a staff scientist in the Physics Division. His ECRP project will develop a new type of detector that can track the particles generated by collisions in particle colliders with high spatial and temporal resolution. Current detectors in use at high-energy colliders, like the ATLAS detector at the Large Hadron Collider (LHC) at CERN, can track the trajectory and measure momentum of particles, but they can’t track a particle’s time of arrival with sufficient precision to discern from which of the many particle interactions they originate. Heim’s proposed technology — called a 4D tracking detector, because it captures data about particles’ positions in space and time — aims to solve this challenge, allowing researchers to glean more precise data from collision experiments to uncover new insights into fundamental forces and potentially discover new particles. The enhanced capabilities of 4D detectors will be a necessity for experiments at future colliders, such as the Muon Collider or Future Circular Collider. The project will develop custom microelectronics that process the signal of a pixelated silicon sensor that can register charged particles passing through it in an extreme radiation environment that these colliders produce during operation. The goal is to measure individual particles’ position with 50-micro-meter spatial and 50 pico-second (one trillionth of a second) temporal precision, for an incoming flux of around 1 billion particles per second per square centimeter. Harrison Lisabeth: Studying underground processes to unleash abundant energy Harrison Lisabeth is a research scientist in the Energy Geoscience Division focused on combining real-world experiments and AI to guide development of geothermal energy systems. His project will explore how deep underground rock formations – where geothermal wells are dug – are stressed by chemical reactions of the minerals and mechanical strain from movements in the Earth. A better understanding of subsurface stresses is essential to engineer safe and reliable geothermal wells that access the heat of deep rocks to produce electricity. It is estimated that the U.S. could generate ten times the amount of energy needed to power the grid using geothermal sources. Lisabeth plans to simulate how minerals grow, dissolve, and influence the behavior of surrounding rock in geothermal reservoirs by tracking chemical changes in rock samples under pressure in the lab. The project will also develop machine learning models to predict geologic strain based on field measurements and refine existing models that describe how common rock types deform under stress. Combining these approaches, Lisabeth hopes to develop a framework to predict stress to improve stability and longevity of geothermal wells. Daniel Carney: Pushing the quantum boundaries of particle measurement Daniel Carney is a staff scientist in the Physics Division who uses quantum information science to study particle physics and gravity. At very small scales, “quantum noise” — random fluctuations from the act of measurement — can drown out faint signals from rare processes. Carney’s ECRP project, “Fundamental Physics at the Quantum Limits of Measurement,” aims to build a new mechanical quantum sensor that can measure extremely small particle interactions below the limits of that quantum noise. The approach uses lasers to hold a tiny bead containing radioactive atoms; when one decays, the system measures the bead’s motion and the energy of any particles emitted. The experiment’s initial goal is to search for heavy sterile neutrinos, hypothetical particles predicted by some extensions of the Standard Model. The system could also help measure the mass of the neutrino, study the way particles interact through the electromagnetic and weak forces, and hunt for low-mass dark matter — all unsolved mysteries in particle physics. Callum Wilkinson: Using machine learning to demystify neutrinos Callum Wilkinson is a staff scientist in the Physics Division and part of the international Deep Underground Neutrino Experiment (DUNE) hosted by Fermi National Accelerator Laboratory. DUNE will create an intense beam of neutrinos that interact in detectors in Illinois and, after an 800-mile journey through the earth, in massive detectors in South Dakota. By precisely measuring neutrinos and how they change, researchers will get a better understanding of their fundamental properties and whether they are responsible for why there is so much more matter than antimatter in our universe. Wilkinson’s ECRP project will apply two machine learning techniques to improve the analysis of DUNE’s data and enhance the experiment’s precision. One approach will look for hidden patterns in how neutrinos interact and produce low-energy particles, while the other will help correct for distortions in what the detectors record. The methods will be tested on one of DUNE’s prototype detectors and could be used in other neutrino experiments, improving their measurements and helping scientists build better models. Aditi Krishnapriyan: Machine learning methods that scale as datasets grow Aditi Krishnapriyan is a faculty scientist in Berkeley Lab’s Applied Mathematics and Computational Research Division (AMCR) and assistant professor at UC Berkeley. Her project, awarded through UC Berkeley, will develop machine learning methods that scale with dataset size for modeling complex, multi-scale phenomena. The resulting tools can be applied in a wide range of research, including the study of new electrolytes for batteries or the examination of molecular interactions. ### Lawrence Berkeley National Laboratory (Berkeley Lab) is committed to groundbreaking research focused on discovery science and solutions for abundant and reliable energy supplies. The lab’s expertise spans materials, chemistry, physics, biology, earth and environmental science, mathematics, and computing. Researchers from around the world rely on the lab’s world-class scientific facilities for their own pioneering research. Founded in 1931 on the belief that the biggest problems are best addressed by teams, Berkeley Lab and its scientists have been recognized with 17 Nobel Prizes. Berkeley Lab is a multiprogram national laboratory managed by the University of California for the U.S. Department of Energy’s Office of Science. DOE’s Office of Science is the single largest supporter of basic research in the physical sciences in the United States, and is working to address some of the most pressing challenges of our time. For more information, please visit energy.gov/science.
Scientists want to put a super laser on the moon
An ultrastable laser could enable extremely precise timing and navigation on the moon, and the cold, dark craters near the lunar poles would be the ideal location for it
Android Find Hub trackers continue to ignore UWB
One of the key marketing points of the Apple AirTag is “Precision Finding,” which shows you the precise location of...
Razer Launches Limited-Edition Boomslang Gaming Mouse for $1,337
Gaming computer company Razer today started accepting pre-orders for the Razer Boomslang mouse, which is being released to celebrate the 20th anniversary of the original peripheral. The original Razer Boomslang was one of the first gaming mice, providing a wheel that boasted more precise mouse tracking than other mic on the market.
Scientists may have discovered a pulsar at the Milky Way’s heart—a result that could reveal new physics
If the pulsar is confirmed, it could enable more precise measurements of the space-time around the galaxy’s central supermassive black hole
This paper-thin chip turns invisible light into a steerable beam
Researchers have built a paper-thin chip that converts infrared light into visible light and directs it precisely, all without mechanical motion. The design overcomes a long-standing efficiency-versus-control problem in light-shaping materials. This opens the door to tiny, highly efficient light sources integrated directly onto chips.
MIT's new brain tool could finally explain consciousness
Scientists still don’t know how the brain turns physical activity into thoughts, feelings, and awareness—but a powerful new tool may help crack the mystery. Researchers at MIT are exploring transcranial focused ultrasound, a noninvasive technology that can precisely stimulate deep regions of the brain that were previously off-limits. In a new “roadmap” paper, they explain how this method could finally let scientists test cause-and-effect in consciousness research, not just observe correlations.
Deflated: Israeli scientists find Jupiter is smaller than previously thought
Using data from NASA's Juno spacecraft, Weizmann Institute of Science researchers make most precise measurement to date, say the gas giant is thinner and flatter than believed
Scientists finally explain statin muscle pain
Statins are a cornerstone of heart health, but muscle pain and weakness cause many patients to quit taking them. Scientists have now identified the precise molecular trigger behind these side effects. They found that statins jam open a critical muscle protein, causing a toxic calcium leak. The discovery could lead to safer statins that keep their life-saving benefits without the muscle damage.
Nature
Genetic variations affect biological processes and can drive disease, but deciphering the precise effects of DNA sequence changes remains a significant...
iOS 26.3 Adds Privacy Setting to Limit Carrier Location Tracking
With iOS 26.3, Apple is adding a new "limit precise location" setting that reduces the location data available to mobile networks to increase user privacy. Mobile networks determine location based on the cellular towers that a device connects to, but with the setting enabled, some of the data typically made available to mobile networks is being restricted.
Distant entangled atoms acting as one sensor deliver stunning precision
Researchers have demonstrated that quantum entanglement can link atoms across space to improve measurement accuracy. By splitting an entangled group of atoms into separate clouds, they were able to measure electromagnetic fields more precisely than before. The technique takes advantage of quantum connections acting at a distance. It could enhance tools such as atomic clocks and gravity sensors.
Roku Starts Rolling Out Roku OS 15.1 Update to Roku TVs & Roku Players - Here is What's New
Roku has rolled out an update to its operating system that brings several improvements aimed at helping developers create better streaming apps for Roku devices. Known as Roku OS 15.1, this version focuses on tools that make app performance smoother, video playback more precise, and development processes more efficient. One major enhancement involves how videos […]
Alarm as US mulls prioritising citizens in research funding
A senior White House official said the Trump administration is considering ways to prioritise research funding to American citizens, triggering alarm in the research community that the country could destroy its century-long status as a magnet for overseas talent.Michael Kratsios, director of the White House Office of Science and Technology Policy (OSTP), said last week that it is “important for us to continue to emphasise the use of federal R&D dollars towards American scientists and technologists that are staffed by Americans in their labs.” Asked about support for Chinese students during a Congressional hearing, Kratsios went on to say that in future funding announcements, the OSTP would “emphasise” that “we're funding American students.”The precise meaning of his impromptu comments, and what they could mean in policy terms, isn’t yet clear. The OSTP did not respond to multiple requests for clarification from Science|Business.But given that US science and technology has relied on overseas talent for the past century, Kratsios’s words have alarmed former US science officials.Immigrants have made up around 30-40% of US Nobel Prize winners since the 1940s, for example. Except for some sensitive projects, countries typically grant research funding on a nationality-blind basis, lest they deter foreign scientists from immigrating. “If director Kratsios’s statements are taken literally and become official policy of the White House, [research-intensive] universities will likely have to close labs if not entire research divisions,” said David Biggs, a former science and technology official in the US State Department. In their most extreme interpretation, Kratsios’s comments would imply that foreign scientists established in the US would see access to funding curtailed. This would “result in many world-leading professors who work in the United States in fields that this administration considers a priority (like fusion energy, artificial intelligence, and quantum computing) leaving the country,” said Cole Donovan, a former US science diplomat, and now associate director at the Federation of American Scientists.CripplingHowever, given the context of the conversation, Kratsios may have been referring more narrowly to funding for doctoral or postdoctoral students. At the hearing, he said he wanted to see labs staffed by US citizens. But even this would have devastating consequences for the US science system, say former officials, because the country is so dependent on early-career foreign researchers. Recent statistics show that nearly half of those in the US with a PhD in science, technology, engineering or mathematics (STEM) are considered short-term visitors, or non-residents in the official terminology. If this included residents who are not yet citizens, the proportion would likely be even higher. “Foreign PhD students are really a significant and core part of the university STEM workforce, and postdocs is similarly large,” said Donovan. Preventing US-based academics from hiring them from overseas would be a serious blow, he said. “If it's the case that this administration intends to limit funding to labs staffed only with US citizens, the effect will be to cripple the American scientific enterprise,” said Chris Marcum, a former OSTP official. “To think that these researchers can simply be replaced is a pipe dream. The labs will close,” said Marcum. Go elsewhereAround half of US-trained postdocs are foreign-born, said Biggs. “If these top international students cannot get funding to do their research, or even if they hear that funding for foreign students has been greatly restricted and will be super competitive, they will no longer choose to study in the US and will go elsewhere.” It’s unclear for now if Kratsios’s comments will translate into a real policy shift. But they could add to turmoil in the US science system since Donald Trump took over as president one year ago. Related articlesNIH turmoil risks reciprocal EU-US access to health research fundingUS set to close office responsible for global science and technology dealsTrump halts new NIH grants to international health-research partnersSince then, nearly 8,000 grants at the National Institutes of Health and National Science Foundation have been frozen or terminated, Naturereports. Courts have overturned most of these cancellations, but the disruption caused remains significant. Both those agencies have also dished out around a quarter fewer grants this year than normal, the journal reported. International student enrolment is also down by 17%. The Trump administration also proposes to cut research budgets by around a third, although Congress may mollify the cuts.
Alarm over US plan to prioritise citizens in research funding
The US’s leading science official has said the country will focus its research spending on scientists with US citizenship, triggering alarm that the country could destroy its century-long status as a magnet for overseas talent.Michael Kratsios, director of the White House Office of Science and Technology Policy (OSTP), said last week that it is “important for us to continue to emphasise the use of federal R&D dollars towards American scientists and technologists that are staffed by Americans in their labs.” Asked about support for Chinese students during a Congressional hearing, Kratsios went on to say that in future funding announcements, the OSTP would “emphasise” that “we're funding American students.”Kratsios’s precise meaning, and what it could mean in policy terms, isn’t yet clear. The OSTP did not respond to multiple requests for clarification from Science|Business.But given that US science and technology has relied on overseas talent for the past century, Kratsios’s words have stunned former US science officials.Immigrants have made up around 30-40% of US Nobel Prize winners since the 1940s, for example. Except for some sensitive projects, countries typically grant research funding on a nationality-blind basis, lest they deter foreign scientists from immigrating. “If director Kratsios’s statements are taken literally and become official policy of the White House, [research-intensive] universities will likely have to close labs if not entire research divisions,” said David Biggs, a former science and technology official in the US State Department. In their most extreme interpretation, Kratsios’s comments would imply that foreign scientists established in the US would see access to funding curtailed. This would “result in many world-leading professors who work in the United States in fields that this administration considers a priority (like fusion energy, artificial intelligence, and quantum computing) leaving the country,” said Cole Donovan, a former US science diplomat, and now associate director at the Federation of American Scientists.CripplingHowever, given the context of the conversation, Kratsios may have been referring more narrowly to funding for doctoral or postdoctoral students. At the hearing, he said he wanted to see labs staffed by US citizens. But even this would have devastating consequences for the US science system, say former officials, because the country is so dependent on early-career foreign researchers. Recent statistics show that nearly half of those in the US with a PhD in science, technology, engineering or mathematics (STEM) are considered short-term visitors, or non-residents in the official terminology. If this included residents who are not yet citizens, the proportion would likely be even higher. “Foreign PhD students are really a significant and core part of the university STEM workforce, and postdocs is similarly large,” said Donovan. Preventing US-based academics from hiring them from overseas would be a serious blow, he said. “If it's the case that this administration intends to limit funding to labs staffed only with US citizens, the effect will be to cripple the American scientific enterprise,” said Chris Marcum, a former OSTP official. “To think that these researchers can simply be replaced is a pipe dream. The labs will close,” said Marcum. Go elsewhereAround half of US-trained postdocs are foreign-born, said Biggs. “If these top international students cannot get funding to do their research, or even if they hear that funding for foreign students has been greatly restricted and will be super competitive, they will no longer choose to study in the US and will go elsewhere.” It’s unclear for now if Kratsios’s comments will translate into a real policy shift. But they could add to turmoil in the US science system since Donald Trump took over as president one year ago. Since then, nearly 8,000 grants at the National Institutes of Health and National Science Foundation have been frozen or terminated, Naturereports. Courts have overturned most of these cancellations, but the disruption caused remains significant. Both those agencies have also dished out around a quarter fewer grants this year than normal, the journal reported. International student enrolment is also down by 17%. The Trump administration also proposes to cut research budgets by around a third, although Congress may mollify the cuts.
Scientists “resurrect” ancient cannabis enzymes with medical promise
Scientists have uncovered how cannabis evolved the ability to make its most famous compounds—THC, CBD, and CBC—by recreating ancient enzymes that existed millions of years ago. These early enzymes were multitaskers, capable of producing several cannabinoids at once, before evolution fine-tuned them into today’s highly specialized forms. By “resurrecting” these long-lost enzymes in the lab, researchers showed how cannabis chemistry became more precise over time—and discovered something unexpected: the ancient versions are often more robust and easier to work with.
Scientists found the brain rhythm that makes your body feel like yours
A new study reveals that alpha brain waves help the brain decide what belongs to your body. Faster rhythms allow the brain to match sight and touch more precisely, strengthening the feeling that a body part is truly yours. Slower rhythms blur that timing, making it harder to separate self from surroundings. The findings could improve prosthetic design and immersive virtual experiences.
Local business strategist helps solopreneurs search into their stars for success
“I want to make sure that they can be as powerful as who they are just with their own gifts, with their energetic alignment, with their precise actions for them,” said Woods, a Master Astrologer and Business Strategist.
This semi-secret Lego Smart Brick feature gives it even more potential
Precise distance measurement.
Superconductors, an opportunity for science and society
Superconductive technologies have long been central to particle physics, but they have also repeatedly moved beyond the laboratory, most notably with the emergence of magnetic resonance imaging scanners (MRI), demonstrating how breakthroughs in fundamental research can benefit society. Today, as global energy, climate and healthcare pressures grow, the conversation is shifting from “What can science give to society?” to “How can science and industry jointly develop technologies that benefit society while advancing research?” The event “Catalysing Impact – Superconductivity for Global Challenges” held at CERN in December was aimed precisely at answering this question. The workshop brought together leading researchers, industry representatives, investors and policymakers to explore how collaboration on superconducting technologies can advance particle physics while addressing some of the world’s most pressing societal challenges. The event sought to bridge fundamental research with real-world deployment and to accelerate collaborative pathways. Across keynotes, panels and round tables, participants examined both the current technological landscape and the opportunities ahead. Introducing the discussions, Frédérick Bordry, Chief Technology Officer of the Gauss Fusion company and former CERN Director for Accelerator and Technology, noted that “Superconductivity has become the silent engine of discovery science.” While the research community needs more capable and more resilient superconductors for the next generation of experiments, they also have significant potential for societal applications. Beyond their role in collider magnets, high-temperature superconductors (HTS) now promise lossless power transmission, compact fusion magnets, efficient renewable systems and new capabilities in healthcare, transport, computing and quantum technologies - all aligned with SDG-17’s emphasis on partnership-driven innovation. Participants also stressed that major hurdles remain. Global competition is accelerating, and Europe must act quickly to secure technological and economic leadership. Doing so will require coordinated investment and supportive policies, including stronger risk capital investment and mechanisms to bridge the gap between laboratory innovation and industrial deployment. The summit set in motion several concrete follow-up priorities, including aligning R&D roadmaps with societal goals and the UN Sustainable Development Goals; making it easier for public–private consortia to build demonstrators that serve both industry and research needs; and advancing investment pathways that better connect research institutions, governments and the private sector. A series of interviews of key participants is available here: Frédérick Bordry & Milena Roveda Mike Lamont Francesca Ferrazza Peter Schroth Ziad Melhem Pietro Corsaro
Scientists Discover How the Uterus “Feels” Its Way Through Childbirth
Molecular discoveries may help improve treatments for labor and pain. When labor starts, the uterus must produce steady, precisely timed contractions to allow a safe delivery. Hormones such as progesterone and oxytocin are known to drive this process, but researchers have long believed that physi
A simple chemistry trick could end forever plastic
Seeing plastic trash while hiking inspired a Rutgers chemist to rethink why synthetic plastics last forever while natural polymers don’t. By mimicking tiny structural features used in DNA and proteins, researchers designed plastics that remain durable but can be triggered to fall apart naturally. The breakdown speed can be precisely tuned, from days to years, or switched on with light or simple chemical signals. The discovery could reshape everything from food packaging to medicine delivery.
Beyond silicon: These shape-shifting molecules could be the future of AI hardware
Scientists have developed molecular devices that can switch roles, behaving as memory, logic, or learning elements within the same structure. The breakthrough comes from precise chemical design that lets electrons and ions reorganize dynamically. Unlike conventional electronics, these devices do not just imitate intelligence but physically encode it. This approach could reshape how future AI hardware is built.
Two unstable atoms are rewriting neutron star explosions
Scientists have precisely measured two unstable atomic nuclei that play a crucial role in explosive X-ray bursts on neutron stars. The results reveal faster nuclear reactions than previously thought, reshaping how we understand element formation in extreme cosmic environments.
Apple’s ‘Invisible AI’ Strategy Is Why 5-Star Analyst Dan Ives Sees Upside Into 2026
Apple Inc. ($AAPL) is best known for iPhones, services, and steady cash returns, not flashy AI launches. Yet that is precisely why top Wedbush analyst Dan Ives sees...
Mini brains reveal clear brain signals of schizophrenia and bipolar disorder
Tiny lab-grown brains are offering an unprecedented look at how schizophrenia and bipolar disorder disrupt neural activity. Researchers found distinct electrical firing patterns that could identify these conditions with high accuracy. The discovery opens the door to more precise diagnoses and personalized drug testing. Instead of guessing medications, doctors may one day see what works before treating the patient.
Subaru Telescope reveals a hidden giant planet
Astronomers have uncovered a massive hidden planet and a rare “failed star” by combining ultra-precise space data with some of the sharpest ground-based images ever taken. Using the Subaru Telescope in Hawaiʻi, the OASIS survey tracked subtle stellar wobbles to pinpoint where unseen worlds were lurking—then captured them directly.
Scientists found a hidden clock inside dinosaur eggshells
Researchers have found that fossilized dinosaur eggshells contain a natural clock that can reveal when dinosaurs lived. The technique delivers surprisingly precise ages and could revolutionize how fossil sites around the world are dated.
Adobe Firefly now supports prompt-based video editing, adds more third-party models
Adobe is updating its AI video-generation app, Firefly, with a new video editor that supports precise prompt-based edits, as well as adding new third-party models for image and video generation, including Black Forest Labs' FLUX.2 and Topaz Astra.
Enabling precise predictions with proton radiography
The polar regions hold some of this country’s most valuable assets. The U.S. has operational bases in both the Arctic and Antarctica that do important work for our national security.