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AIFF to offer 40 film programs, four days of entertainment
Ashland-born filmmaker to screen debut feature film ‘A Simple Machine’ Celebrating its 25th anniversary, the Ashland Independent Film Festival is set to return in late April, bringing in acclaimed filmmakers […]
Surfshark Just Dropped a Next-Gen VPN Protocol That Could Be Faster and More Secure Than Other VPN Connections
The new Dausos connection protocol has been independently audited and includes a few key innovations not found in other VPNs.
‘I’m playing the long game’: Journalists are striking out alone and discovering the business is toughest beat of all
News Creators have become preferred sources for younger viewers, but how do they grow and sustain their independent endeavors?
Science Pub: Investigating the Lithium Rush
Lithium has been described as “white gold,” the next oil, or a kind of savior from climate change. Consumers are
Baseball great Phil Garner dies aged 76 after cancer battle
Phil Garner has passed away at the age of 76
What Flutter Entertainment (FLUT)'s Board Shuffle, Buybacks and Quiet Dart Stake Mean For Shareholders
In recent days, Flutter Entertainment plc reported that long-serving independent director Alfred F. Hurley, Jr. will retire at the 2026 AGM, with Nancy Dubuc set to assume the role of Chair of the Compensation and Human Resources Committee, while the company continues executing a multi-billion-dollar share repurchase program. At the same time, billionaire investor Kenneth Dart has quietly built substantial economic exposure to Flutter through total return swaps, even as analysts question...
Protecting Taxpayers Means Looking Beyond the Politics of Short-Term Rentals
Santa Barbara is on the verge of making a consequential decision about short-term rentals — but without first answering a basic question: What will it cost?
LeBron James hits NBA milestone as LA Lakers crush Suns
James became only the fourth NBA player to reach the milestone
Best of Your Hometown Community’s Choice Awards business spotlight: Pracht Law Firm
We’re in the final stretch! Ready to recognize your favorite local businesses? Submit your nominations for Best of Your Hometown Community’s Choice Awards today.
What’s at stake as Michigan voters weigh constitutional convention question
Conservatives could try to repeal the state constitution's guarantee of the right to an abortion.
Science finds surprising link between your martial status and risk of cancer
Married people tend to have greater financial stability and stronger social support, which can help them maintain healthier habits and get medical care earlier, researchers noted
Science finds surprising link between your martial status and risk of cancer
Married people tend to have greater financial stability and stronger social support, which can help them maintain healthier habits and get medical care earlier, researchers noted
Robert MacIntyre faces reprimand after giving Masters the middle finger
MacIntyre made a quadruple-bogey-nine on the 15th after finding the water twice in a nightmare round of +8
New YouTube Report Shows How Online Animators Are Reshaping the Entertainment Industry
YouTube has released a new report on how independent animators creating straight-to-audiences content on YouTube are reshaping the industry.
Ex-Sports Haven Building To Be Demolished
Dozens of chairs were piled high outside of the fenced-off former Sports Haven site Thursday -- as crews clear out the shuttered off-track-betting venue in advance of the building's coming demolition.
3L Rachel Sadler Charts Path in Brain Health, Technology, and Policy Through UC Law SF’s Health Law Concentration - UC Law San Francisco (Formerly UC Hastings)
3L Rachel Sadler studies health law and policy at UC Law SF while researching the legal implications of neurotechnology and other emerging tools that may affect human cognition. 3L student Rachel Sadler shares how UC Law SF’s Health Law Concentration prepared her for a career focused on the intersection of brain health, government policy, and technology. Gained a detailed understanding of how U.S. health care is regulated and where policy reform is needed through coursework and research. Interned with state and federal agencies that regulate health care services and worked with a major health care provider’s bioethics department. Plans to pursue a career focused on protecting cognitive liberty and mental privacy as new technologies reshape healthcare. 3L Rachel Sadler: The Health Law Concentration has given me fluency in one of the most complex regulated industries and the tools to become an effective advocate for better health policy. Before coming to law school, I spent a decade teaching and working with teachers and administrators on high school programming for multilingual learners. Healthcare kept emerging as the most powerful driver of student outcomes. I wanted to understand how to make effective policy change in this area and how to use existing law to defend people’s health rights in California. Through the concentration’s coursework, I gained a sophisticated understanding of how U.S. healthcare is regulated. I also learned where the pressure points for reform exist. The courses gave me space to develop what became my central research interest: how law and policy can be built to protect human cognition and healthy brain development, particularly regarding new technologies such as generative AI and neurotechnology. The health law faculty were instrumental in that process, genuinely invested in helping me and other students define and pursue our own intellectual vision. During law school, I interned at the General Counsel’s Office for Region IX of the U.S. Department of Health and Human Services. I also externed at the California Department of Justice’s Health, Education and Welfare Division. Additionally, I externed at Kaiser Permanente Northern California’s Bioethics Department. Alongside those placements, I conducted extensive independent research on mental privacy and emerging neurotechnology, working closely with Professors Emily Murphy and George Horvath. That research became the throughline of my law school experience and the foundation of my current policy focus. I must also credit Nicole Ozer of the Center for Constitutional Democracy (CCD), whose deep knowledge of California privacy law and the public-interest privacy landscape deeply informed my work. I currently serve a research assistant with the CCD, where I spearhead the development of K-12 educational resources in partnership with law faculty and students. I’ve found UC Law SF to be an ideal place for second-career, nontraditional students. There is a tremendous diversity of life and career experience here, and I felt fully welcomed into the community, despite returning as a student at a different stage of life. I came to law school wanting to promote equity in California’s healthcare system. I am leaving with a sharper and more specific ambition: to build a policy career focused on protecting cognitive liberty and mental privacy from technological intrusion. This is both an urgent and underserved area of law, and I want to be part of defining this landscape going forward. Whether as a practicing attorney or a policy advisor, I plan to work on these issues after law school. I strongly recommend UC Law SF and the Health Law Concentration. When I arrived in law school, I worried the concentration would be narrow and that my non-clinical background would be a disadvantage. The opposite was true. The health law faculty thinks about health expansively, encompassing social determinants of health, structural inequity, and emerging technologies alongside the regulatory mechanics of the industry. The faculty are accessible, intellectually generous, and genuinely invested in students’ development. I found my research vision here, and I deeply appreciate the concentration’s role in this. The Evidence of Success series highlights UC Law SF students as they share how the College’s opportunities equip them with the experience, skills, and confidence to excel in the legal profession.
New YouTube report shows how online animators are reshaping the entertainment industry
Independent creators on YouTube are redefining the animation landscape as global audiences shift their focus toward original online series. This report explores how a new generation of animators reaches millions of people through digital platforms and cross-language content.
Ishbia family taking swing at youth sports facility for vacant Office Depot
(Editor’s Note: Alex Harrison Perry reported this story for Evanston RoundTable, a neighboring independent newsroom. It was shared with The Record as part of an ongoing collaborative effort.) The vacant Office Depot building at 2722 Green Bay Road — just a block south of Wilmette — could become a year-round site for youth sports, as a North Shore family […]
In Search of Health Care Options for Real Estate Agents
Real estate professionals who work as independent contractors often face expensive health care choices, but brokers and associations are finding new ways to expand access and support agents’ financial well-being.
2026 Texas Science and Engineering Fair Results
Posts Details/Default Board Post Page - Plano Independent School District
Executive Summary: A Patients’ Bill of Rights To Lower Health Care Costs
CAP’s plan would limit unjustified premium increases; reduce deductibles by reining in outlier hospital prices; and replace prior authorization with independent, evidence-based clinical review to lower health care costs and increase access to timely care.
Business opposition growing to plan to replace Missouri income tax with sales tax
A business lobbying group is stepping up its opposition to a proposal to replace the Missouri income tax with sales taxes.
Bone rescans 'another example of health inequalities' in Jersey
Patients have been called for a repeat scan after an independent review found "potential concerns".
‘No Labels’ Arizona Wants to Rebrand as the Independent Party
Both the Democratic and Republican parties in Arizona have been locked in a legal battle with a chapter of the group “No Labels” as it tries to rechristen itself.
Opinion: Why Alaska may point to the future of independent politics
Rather than labeling themselves as independents in protest of dysfunctional Republicans and Democrats, the title now stands for pragmatism and common-sense.
White House shuts down speculation about Trump’s absence over health: ‘literally never stops working’
The Blue Flame offers entertainment spot for UNH students despite age policy change
The independent student newspaper of New Hampshire University since 1911.
Scientists discover fossils that change what we know about evolution
Scientists have discovered fossils in China that reveal a crucial transition from simple to complex life on Earth
Club sports serve as a pathway to varsity level athletics
While club and varsity sports operate as independent units, participants are all athletes on one campus. As a Division III school, opportunities arise for club athletes to play on a bigger field, and vice versa. For senior lacrosse goalkeeper Nichole Allan, the chance did not come until her final semester at Ithaca College.
Your Party to focus local election efforts on backing independent candidates
The party, whose parliamentary leader is Jeremy Corbyn, will back 250 candidates, focusing on urban areas
Sen. Marshall meets Kansas small business owners on key issues
TOPEKA (KSNT) – Small business owners from across Kansas met April 1, with Senator Roger Marshall and the National Federation of Independent Business to discuss the issues they say are puttin…
Sen. Marshall meets Kansas small business owners on key issues
TOPEKA (KSNT) – Small business owners from across Kansas met April 1, with Senator Roger Marshall and the National Federation of Independent Business to discuss the issues they say are putting the mos...
Wisconsin state government will look vastly different after wave of retirements
A Wisconsin political scientist says next year will be a 'fundamentally new reality in the Capitol.'
Will California elect a GOP governor? Democrats are panicked
Odds of the GOP grabbing both slots in the June primary aren't high, but aren't zero. Nervous Democrats ponder options like a write-in or independent candidate.
Poll shows Carlos Giménez’s lead narrowing in CD 28 amid economic, policy headwinds
A potential new entrant to the race could capitalize on independent voters breaking toward Democrats, pollsters found.
Guest column: Get partisanship out to Deschutes County politics
It is time to wrench two-party partisanship out of Deschutes County politics. As a registered Independent, I joined an overwhelming majority of voters in the recent elections to make the […]
Climate Science Has No Place in Scientific Reference Manual for Judges, Attorneys General Say
A chapter on climate science has been removed from a manual designed to be an independent, neutral source of scientific information for judges.
Scientists achieve ‘impossible’ solar efficiency in renewables breakthrough
‘Spin-flip’ technique promises to shatter efficiency limits
Missouri bill to cut off recurring political donations moves toward state Senate debate
A Missouri Senate committee gave a warm reception to a bill to bar candidates from raising money with automatically recurring donations.
With Sam Graves retiring, Missouri stands to lose a key power broker in Washington
Sam Graves’ retirement marked the exit of one of the few Missouri politicians in Washington who had turned time in office into real institutional power.
The Trump-voting pastor Democrats think could cost them a chance at a Nebraska Senate seat
In Nebraska’s Senate race, a Trump-supporting, anti-abortion pastor is running as a Democrat. The state’s Democratic Party — which is backing an independent candidate — says he’s a Republican plant. And another Democratic primary candidate says she’s running just to stop him.
AKC Canine Health Foundation Joins All Access hosted by Andy Garcia to Explore the Science of Veterinary Innovation
The AKC Canine Health Foundation (CHF) is excited to announce a collaboration with the educational program "All Access hosted by Andy Garcia" to develop a documentary segment centered on canine health research. Set to film on April 15, 2026, at the Foundation's headquarters and the North Carolina State University College of Veterinary Medicine, the production will provide an objective look at how independent research improves the well-being of dogs, through highlighting CHF's pivotal role as a f
The psychology of holidays: the perfect space between breaks according to science
As the great Easter break begins, It’s tempting to base annual leave around maximising days out of the office, but there’s a much better way to make the most of your holiday. Lydia Spencer-Elliott followed made one big change to her annual leave schedule and was shocked by the benefits
Politics Unplugged (Full Episode) March 29, 2026
This week on Politics Unplugged, Secretary of State Adrian Fontes discusses a judge’s ruling that the No Labels Party can’t change its name to the Arizona Independent Party. Then, consultants Stacy Pearson and Matt Benson discuss the impact of high gas prices in Arizona and the Phoenix City Council's vote restricting ICE's use of public facilities.
Tottenham release statement as Igor Tudor departs after 44 days
The 47-year-old won just won of his seven matches in charge of Spurs who are fighting to avoid relegation from the Premier League
Hingham Schools Eye Business Curriculum Expansion as Class Size Concerns Mount
HINGHAM - March 23, 2026 - The Hingham School Committee moved to modernize its high school offerings Monday night, reviewing a comprehensive plan to expand the “small but mighty” Business Department while simultaneously grappling with data that places Hingham as an outlier in elementary class sizes. Director of Social Studies Andy Hoey presented a two-year program review that highlighted the department’s success in community partnerships but warned that high student demand is testing current staffing limits. Meanwhile, committee Chair Jen Benham presented independent research showing Hingham is the only benchmark district with second-grade classes hitting a 25-student cap, sparking a directive for the Policy Subcommittee to review class-size standards. Editors note: South Shore News is going paid in April, subscribe now to make sure you don’t miss a story. Reach out for group or organizational pricing. Subscribe The Full Story The meeting opened with a look into the future of Hingham High School’s (HHS) curriculum. Andy Hoey, who oversees the Business Department, presented the first formal program review for the department since 2009. [15:09] Hoey characterized the department as a vital elective hub that currently serves between 14% and 27% of the HHS student body in any given year. [31:31] “We are very proud of our business department here at Hingham High School... while we’re very proud of it, we are always striving to make improvements and enhancements.” [15:55] — Andy Hoey, Director of Social Studies A key highlight of the presentation was the announcement of a new AP Business with Personal Finance course launching next year, pending enrollment. [20:08] The review team found that while the program is “well-aligned” to national standards, it remains a high-school-only offering. Hoey outlined an action plan to explore “vertical articulation,” potentially introducing business or financial literacy units at the middle school level to fill a “gap” identified between fifth and eighth grade. [41:48] However, the department faces “smoke and mirrors” regarding student GPA, according to Hoey. Currently, most business courses are “unleveled” and do not count toward a student’s GPA, which survey data suggests may deter some students from enrolling. [28:15] The committee discussed the possibility of offering Honors or College Prep (CP) credit for advanced courses, such as investing or marketing, to better reflect their academic rigor. [38:27] The discussion took a sharp turn toward elementary education during an enrollment update. Superintendent Dr. Katie Roberts noted a net gain of four students mid-year, but it was Jen Benham’s “rabbit hole” data analysis that caught the committee’s attention. [50:35] Benham researched 13 benchmark towns—representing 34 elementary schools—and found that Hingham was the only district with a second-grade section reaching 25 students this year. [51:36] Benham’s findings suggested that while many districts lack formal class-size policies, Hingham’s current cap of 25 for second grade may be too high. “I think if we could at least have 23 at a cap for grade two,” Benham suggested, noting the importance of that grade level for literacy development. [53:09], [54:55] Dr. Roberts cautioned that smaller classes require more staff, which is a significant hurdle following a budget season where nine general education positions were cut across the district. [55:56] The committee also finalized the 2025 Town Report, which was updated to be more “student-centered” and highlight staff early in the document. [11:12] Additionally, a series of food service policies were approved to align with Massachusetts’ universal free school meal mandate, including new protocols for meal modifications due to allergies or religious needs. [59:23] Share Why It Matters The meeting underscored a tension between Hingham’s desire to offer elite, specialized programming and the foundational pressure of class sizes. The expansion of the Business Department—including potential Microsoft certifications and AP courses—aims to prepare students for a “real world” where credit scores and financial literacy are paramount. [46:20] However, the revelation that Hingham’s second-grade classes are larger than those in all neighboring benchmark towns suggests a potential strain on early education that could impact long-term student performance if not addressed by the Policy Subcommittee. Official Minutes & Data Key Motions & Votes Motion: To approve the Hingham Public Schools 2025 Town Report. [13:16] Vote: Unanimous (7-0) ([01:13:28]) Motion: To approve the Memorandum of Agreement (MOA) for summer counselor work regarding course placement. [57:33] Vote: Unanimous (7-0) ([57:50]) Motion: To approve Policy EFBA (School Food and Nutrition/Meal Modifications). [01:00:32] Vote: Unanimous (7-0) ([01:00:44]) Motion: To approve Policy EFC (Universal Free School Meals). [01:00:54] Vote: Unanimous (7-0) ([01:01:07]) Public Comment No members of the public spoke during the meeting or via the remote link. [01:02:30] What’s Next The Policy Subcommittee will take up the review of elementary class-size caps over the next year to determine if the Grade 2 limit should be lowered from 25 to 23. [52:18] The Business Department will monitor enrollment for the new AP Business course and continue exploring dual-enrollment partnerships with Quincy College. [38:13] Source Video: Harbor Media South Shore News is a reader-supported publication. To receive new posts and support my work, consider becoming a free or paid subscriber. Subscribe
Floyd Mayweather reveals Manny Pacquiao rematch will be an ‘exhibition’
The pair are set to resume their rivalry in September but Mayweather has cast doubt on whether this bout will be his return to professional boxing
Scientists mimicking the Big Bang accidentally turn lead into gold
The physicists made an unexpected breakthrough
Short-Term Rental Policy Is Politics, Not Planning
Santa Barbara’s Flawed STR ordinance is being rushed ahead.
12 Cool New Apps That Will Upgrade Your Mac Experience In 2026
The Mac has a thriving developer community, with independents and large companies both introducing new and interesting apps for the platform in 2026.
Council members approve live entertainment pilot program, construction contracts
Reno's independent, online news and events source. Established in 2009.
Book Review: Politics Without Politicians: The Case for Citizen Rule, Hélène Landemore
During the ratification battle over the United States Constitution, the Federalists and Anti-Federalists were divided on many issues. One major axis of
Ashley Benson Signs With Strand Entertainment
EXCLUSIVE: Strand Entertainment has signed Ashley Benson, an actress and producer whose work spans studio features, independent film, and television, for management. Benson was most recently seen star...
A surprise resignation could open the door for an independent to win a Montana Senate seat
Two-term GOP Sen. Steve Daines shocked Montana when he announced his retirement. Democrats worry a new independent candidate will split their party's vote.
Cottage Health Appoints Melissa Ruiz, MD, MPH, as Endowed Chair of Pediatric Residency Program
Credit: Courtesy SANTA BARBARA, CA—March 25, 2026—Cottage Health has appointed Melissa Ruiz, MD, MPH, as the Endowed Chair of the Pediatric Residency
The Pharmacy Business Model Is Breaking. States Are Scrambling To Fix It.
The crisis may be much broader than just independent pharmacies. The business of community pharmacy as a whole is under duress.
Arsenal exploring blockbuster summer move for PSG’s Khvicha Kvaratskhelia
Arsenal are exploring a blockbuster summer move for PSG winger Khvicha Kvaratskhelia (25), according to The Independent’s Miguel Delaney. The winger has proved an immediate hit for Les Parisiens o...
Aspen Medical Care joins Aspen Valley Health Primary Care
Aspen Valley Health has announced that Aspen Medical Care, a long-standing independent primary care practice serving the Roaring Fork Valley since 1997, will become part of its Primary Care network.
I didn’t pay attention to politics. Then my house fell down
This Overland Park independent voter is reminded of his father’s advice, and applies it to our democracy. | Opinion
Democracy Depends on Science—So Scientists Need to Show Up for Democracy
A shared commitment to facts and knowledge, produced independently from political interference, is critical to democracy—and worth fighting to protect.
Barber: Data centers and live entertainment regulations
Reno's independent, online news and events source. Established in 2009.
Court ruling reverses denial of Sunland Park entertainment venue
EL PASO, Texas (KTSM) — A recent court ruling is reversing the City of Sunland Park’s denial of a project that would create an entertainment venue and hospitality project, the developer…
Prologue Entertainment Taps Ken Segna As Head Of Television Development
EXCLUSIVE: Prologue Entertainment, the independent film and television studio that produced Netflix thrillers Zero Day and A House of Dynamite, is expanding its ranks, naming Ken Segna as Head of Tele...
Differences between W2 and 1099 workers for small businesses
Hiring for your small business? One of the first decisions you’ll face is who to hire and how to classify them. Should you bring on a W-2 employee or a 1099 independent contractor? In this episode of Small Business Smarts, ADP’s Laci Buzzelli breaks down the key differences between the two and when each option makes the most sense for small businesses. For more information, visit ADP.com/SPARK
iPhone Air Said to Be Roughly Twice as Popular as iPhone 16 Plus
While it certainly has its critics, the iPhone Air appears to have validated Apple's decision to retire the iPhone Plus, if new results from an independent analysis are anything to go by. Crowdsourced Speedtest data published by Ookla suggests the iPhone Air captured 6.8 percent of iPhone 17 generation samples in the U.S. during the fourth quarter of 2025, up from the 2.9 percent share the iPhone 16 Plus managed in the same launch window a year earlier.
Grub Lab: $6 Million Raised To Bring Sports And Entertainment IP To Independent Restaurants Nationwide
Grub Lab, an Australia-founded restaurant technology startup, announced it has raised $6 million in funding from Quantaco to accelerate its expansion across the United States and support a national rollout tied to major sports leagues and entertainment studios. The company is positioning itself as a modern solution to help independent restaurants compete for family dining traffic through interactive, branded experiences.
Kathy Ireland Accuses Business Managers of Looting Her Fortune
The model-turned-entrepreneur and lifelong Santa Barbara resident claims decades-long deception left her virtually broke.
Your Thymus and Your Healthspan
Our thymus gland plays a central role in the development or our immune system, specifically for supporting T cell development (how these cells got their name, maturation and differentiation in the thymus) and discriminating between self and foreign, non-self antigen proteins with production of dendritic cells. As we age, our thymus gland shrinks—the process known as involution—with progressive change from spongy to fatty tissue, with loss of functionality. But this process, with respect to timeline and extent, markedly varies from one person to the next. And to make things even more complicated, our thymus gland anatomy and precise location in the chest also is highly variable. So the famous Frank Netter diagrams from the 1960s (such as at left below) don’t capture the remarkable heterogeneity that a random set of 12 chest CT scans (below at right). What I consider as 2 landmark papers in Nature this week (here and here) used AI to quantify health of the thymus in 2 large cohorts, and then correlate the metric to a broad array of health outcomes. In this edition of Ground Truths, I’m going to cover three questions: (1) How was thymus health determined by AI?; (2) How is thymus health linked to key clinical outcomes? and (3) Are there ways we can promote a healthy (aka rejuvenate) thymus gland in our later years? Subscribe 1. How was thymus health determined by AI? This was accomplished by extensive work developing and validating an AI pipeline for 2 stages, the first for localization and segmentation of the thymus bed, and the second to quantify a digital marker, termed the thymic health score. There’s a lot to this algorithmic development, so I won’t go into all the details, but just provide a rudimentary outline of what was done. The 1st stage used supervised learning with 2 radiologists reviewing 2,461 chest CT scans. That work trained a 3D U-Net model to automatically identify the thymic bed’s 3D cropped region using center of mass coordinates, which reached 99.8% accuracy. The 2nd stage used a foundation model that was pre-trained with SwAV (which stands for Swapping Assignment between multiple Views), a self-supervised model, that generated a high-dimensional thymus representation of 4,096 features. That compares to the radiology reductionist and subjective scoring of 0 to 3 where 0 means the thymus is fully degenerated and fatty, and 3 is considered dense, intact glandular soft tissue. Notably, the self-supervised learning (SSL) performance was superior to supervised (AUC ~0.75 vs 0.55, respectively) reflecting the shallowness of the 0-3 classifier vs SSL’s holistic, self-taught AI. The thymic health score ranged from 0 to 100, with the highest number indexed to fully preserved thymic health. The algorithmic work extended to explainability with both Shapely value distribution, meaning the model was holistic not relying on any “magic” pixel, and occlusion sensitivity, demonstrating the model’s performance was not affected by ribs, sternum, lung tissue, but rather focused on the thymic bed directly. Below are a few saliency maps from the occlusion sensitivity that indicate the thymic bed focus, not affected by neighboring structures, using the jet color scale. Now the AI was ready for processing ~25,000 CT scans, each over 30 MB files, from the 2 large participant cohorts to provide a thymic health score, it did so in less than 14 hours, which is less than 2 seconds per scan! Share 2. How is thymus health linked to key clinical outcomes? The two cohorts were the National Lung Screening Trial, NLST (N=25,031) and the Framingham Heart Study, FHS (N=2,581) each with baseline demographics and long term follow up of >12 years for health outcomes. From the NSLT, you can see below that increased age and body-mass index were correlated to reduced thymic health. And, overall, men had reduced thymic health scores compared with women. There are a lot of graphs in the paper for outcomes, for both the NLST and FHS cohorts. To simplify the major outcomes, below is a composite Figure with striking reduction of all-cause mortality and for the different causes of death. The results were consistent between the 2 cohorts. For example, the cardiovascular mortality hazard ratio average was 0.57 in NLST and 0.38 in FHS (weighted to be 0.53 for the aggregate). The reduction of mortality also extended to digestive diseases and pulmonary disease (data not shown below). Lung cancer incidence was reduced by 36% for high vs low thymic health (Figure below, with a panel -incidence and b panel-mortality, adjusted for age, sex, BMI, smoking status). Notably, there was a smoker’s paradox: lower incidence and improved survival for lung cancer in smokers who had a high thymus health score. Smoking was associated with lower thymic scores whereas alcohol was not. Higher thymic health was linked to higher HDL cholesterol, lower triglycerides, lower fasting blood glucose, and lower systolic and diastolic blood pressure. Inflammation biomarkers, such as C-reactive protein and interleukin-6, were elevated in the people with lower thymic health scores. In their second paper, the same team looked at the relationship between thymic score and outcomes for 3,476 patients receiving cancer immunotherapy. The non-small cell lung cancer progression-free survival was reduced in patients with low thymic health score. A parallel relationship for survival was seen for other types of cancer including melanoma, breast, and kidney with a 44% lower risk among high thymic scores (Figure). A similar pattern was seen with different immune checkpoint inhibitors. The thymus health score outperformed programmed death ligand-1 (PD-L1)and tumor mutation burden (TMB) assay of the tumor and was an independent prognostic marker of progression-free survival. In this dataset, a direct connect with thymus score and adaptive immune function was noted with a correlation before cancer treatment for both T-cell diversity and thymus T-cell production (a metric known as T cell receptor excision circles). Thymus Removal Study There is a highly relevant citation about thymus function before moving onto ways to rejuvenate it. In 2023, a very important study of thymus removal during cardiothoracic surgery was published, with 1146 patients undergoing thymus removal vs 1146 matched controls (mean age 55 years). The adverse outcomes for thymus removal were striking, with a 2.9 higher risk of all-cause mortality and doubling of cancer incidence, 1.5 fold increase in cancer mortality, and 1.5-fold increase in autoimmune diseases. The immune function showed marked compromise after thymus removal, as reflected by CD4+ and CD8+ T cells (Figure below) Share Ground Truths 3. Are there ways we can promote a healthy (aka rejuvenate) thymus gland in our later years? In recent months we’ve learned a lot about the process of thymus involution and the pathways by which this may be modulated. Thymus involution is primarily due to loss to thymus epithelial cells (TECs) and there are 2 subtypes with different functions: the cortical, responsible for positive selection of T cells, and the medullary, for negative selection. When adipose tissue infiltrates the thymus, thymic adipocytes are pro-inflammatory, knocking out T-cell output. Likewise, systemic inflammation, or “inflammaging,” from smoking, obesity, and chronic stress promote thymic adipocytes. Now, from preclinical studies, we know about key pathways that account for these processes. Historically, back in 2014, FOXN1 was recognized as a single master transcription factor essential for TEC function, with studies in mice with forced FOXN1 upregulation leading to thymus regeneration. That laid the foundation for potential regrowth of quiescent thymus cells. It took awhile to find pathways to accomplish this goal and to even refute its role as the master regulator. The Liver-Thymus Axis Feng Zhang and his team recently showed that injection of an mRNA vaccine to the liver encoding DLL1, IL-7 and FLT3-L in combination, factors known to support thymopoiesis (Figure), successfully enhanced immune function in aged mice. However, the effect was transient. The FGF21 Story Two reports in 2025 addressed the thymus gland’s production of FGF21, a growth factor (fibroblast growth factor 21) and its control of thymus involution. This growth factor is also produced by the liver, but it doesn’t have impact on the thymus in aged rodent models. In contrast, The liver’s hepatocyte growth factor (HGF) has been shown to reverse senescent TEC structural changes. Growth hormone stimulates production of insulin growth factor-1 (IGF-1) in the liver and the thymus. Two small studies in human participants (TRIIM, for Thymus Regeneration, Immunorestoration, and Insulin Mitigation) of 6 and 50 people, respectively, treated with combined human growth hormone, metformin and DHEA, suggested the potential of slowing epigenetic aging and improving thymus mass and function. But the combination of drugs, small sample, and lack of controls make conclusions murky. Increased thymus FGF21 led to increased CD8 T cells in old mice and extended healthspan and improved physical performance. Building on the previous FOXN1 data, ablation of β-klotho, the obligatory co-receptor for FOXN1, accelerated thymic aging. The benefit to FGF21 was confirmed in a companion paper using an FGF21 knock-in mouse model showing thymus enlargement and increased TECs throughout the lifespan. (schematic Figure below). The accompanying editorial for these 2 papers speculated: “The proposed link between age-associated thymus involution and organismal aging is intriguing, and suggests we might seek to achieve systemic rejuvenation by counteracting thymic involution.” Other Factors Lessons from the Axolotl (Mexican Salamander) In an elegant set of experiments of the axolotl (Figure), known for its complete thymus regeneration after total surgical removal, mediators were identified. Surprisingly FOXN1 was dispensable. But midkine, a growth factor, appeared to be the driver, the initiator of thymus cell growth, survival, and repair. Other components that contributed were Postn+ (periostin-expressing mesenchymal niches) and Ccl19, a chemokine protein from the bloodstream. RANK and RANKL RANK (receptor activator of nuclear factor κB its ligand (RANKL) have been considered key regulators of medullary TECs. In a study of both aged mice and human thymus cell cultures, their key role was confirmed, with multiple benefits of resorting TEC function, recruitment of progenitor cells, and T cell development. Subscribe Summing Up This body of work strongly supports the health of the thymus gland as a critical regulator of human healthspan, not just a correlate or link. The new landmark studies are reinforced by the regenerative biology experimental models that have shown, via an array of mediators, that healthspan of aged mice is at least in part dependent on thymus gland function and its critical role for maintaining adaptive immunity. It sure seems that we’d be better off having an immune reservoir of naive T cells instead of a profile in older adults of exhausted, low quality, memory T cells, with a senescent phenotype. It is striking that we ignored the importance of the thymus gland for many decades. A wake-up call was the results of the thymectomy matched control study reviewed here, with the opposite of high thymic health score improved health outcomes. The convergence of AI and healthspan here is notable. The exceptional and laborious work for developing and validating (no less explaining) the AI to quantify thymus health set the foundation for probing the connect the major health outcomes in two cohorts with extensive follow-up. We’ve never had a way to meaningfully quantify the thymus gland before, so this represents important leverage of supervised, self-supervised, and transformer models. The study wouldn’t have been possible without AI. And it begs the question as to whether there are ways we can maintain our thymus at a high health score. But it’s not so simple to rejuvenate our thymus. There are multiple risks including the induction of autoimmunity, increasing the risk of cancer, and inducing a pro-inflammatory state. For example, factors that increase TEC proliferation could compromise the medulllary negative selection process and leak out auto-reactive (self-attacking) T cells. Thymic cells could be induced to proliferate, but we know, for example, that growth hormone and IGF-1 are associated with an increase risk of cancer. If thymus rejuvenation doesn’t clear out the accumulated senescent cells in older adults, then inflammation within the gland could block the production of TECs. Keeping these risks in mind, we now have identified many ways to keep our thymus healthy as we age that undoubtedly will be tested in clinical trials going forward. Ultimately, the benefit-to-risk tradeoffs will be defined. In the meantime, we have desperately needed an immunome. As I’ve stressed in multiple prior Ground Truths, we have no test in the clinic to assess a patient’s immune status! It was very encouraging for me to get an email from Hugo Aerts, the senior author of the landmark papers in the days after they were published: “I also wanted to say that your Substack on “Why We Need an Immunome” was inspiring for this work. We found it a very compelling perspective and greatly enjoyed reading it.” Just having an assessment of a person’s immune status via a chest CT scan, with millions of these performed per year, might help in guiding the right immunotherapy for cancer (e.g. more intensive, combinations for those with low thymic health scores) and help define people who are increased risk for age-related diseases of cancer, cardiovascular, and neurodegenerative. The main theme of Super Agers is that we now have many layers of data (genetics, proteins, biomarkers, organ clocks that can be integrated via multimodal AI) for us to define a person’s specific risk decades before one of these age-related diseases leads to symptoms, enabling prevention. From the new studies this week, we can add thymus health score as yet another way to understand a person’s risk, a window into their adaptive immune system and healthspan. And perhaps someday we will be able to safely rejuvenate the thymus, or maintain its health through one’s life, and use the thymus health score to monitor. NB: I wrote this post (No A.I.) A Quick Poll Loading... ********************************************************************* Thanks to Ground Truths subscribers (now > 200,000) from every US state and 212 countries. Your subscription to these free essays and podcasts makes my work in putting them together worthwhile. Please join! If you found this interesting PLEASE share it! Share Ground Truths Paid subscriptions are voluntary and all proceeds from them go to support Scripps Research. They do allow for posting comments and questions, which I do my best to respond to. Please don’t hesitate to post comments and give me feedback. Let me know topics that you would like to see covered. Leave a comment Many thanks to those who have contributed—they have greatly helped fund our summer internship programs for the past two years. It enabled us to accept and support 47 summer interns in 2025! We aim to accept even more of the several thousand who will apply for summer 2026.
This CEO took legal advice from ChatGPT to avoid paying $250 million bonus. It backfired
The court stressed that company executives are expected to exercise independent judgment, not outsource good-faith decisions to an AI.
Why mosquitoes always find you and how they decide to attack
Scientists have finally cracked how mosquitoes decide where to fly—and it’s not by following each other. Instead, each insect independently reacts to visual cues and carbon dioxide, zeroing in on humans when both signals align. Dark colors and CO2 together create the strongest attraction, triggering swarming and biting behavior. This insight could reshape how we design traps and prevent mosquito-borne diseases.
Jack Draper blown away in ‘difficult’ Miami Open exit
The giant Opelka fired down 25 aces and 47 winners in two tiebreak sets, winning 7-6 (3) 7-6 (0), as Draper suffered a second-round exit
Striking Down Pentagon Press Limits, Judge Vindicates Independent Journalism
The ruling cut deeper than left-versus-right politics, declaring that the policy imposed by Defense Secretary Pete Hegseth is unconstitutional.
Pentagon policy limiting independent press access is unlawful, judge rules
A federal judge on Friday voided various parts of a restrictive press policy rolled out by Defense Secretary Pete Hegseth last year, ruling that they trampled on the constitutional rights of reporters who seek to cover the US military from within its sprawling headquarters.
Markiplier to Microdramas: The Ankler x NAB Show’s Future of Entertainment
Share Subscribe Vegas, baby! The Ankler is heading back to NAB Show for a second year in a row — and doubling down on conversations with the smartest people in the industry. From April 18–22, we’re partnering again with the industry’s biggest media and tech gathering to break down the Business of Media and Entertainment as it’s actually evolving: faster, riskier and increasingly driven by new formats, new audiences and new power players. This curated series will bring together top creators, executives and innovators to tackle the forces reshaping the industry — from the AI disruption of Hollywood’s creative ecosystem to the rise of the creator economy, shifting audience behavior and the changing economics of production. We’ll be rolling out more programming in the coming weeks — including top speakers from leading AI studios, prediction markets and beyond — so keep an eye on the Business of Media and Entertainment hub. But first up, we’re announcing two panels about what’s actually working in Hollywood: The Scary-Smart Business of Horror A good scare has become one of the entertainment economy’s most reliable engines. With disciplined budgets, built-in fandoms and global box office upside, horror consistently outperforms. From theatrical releases to streaming-first originals and creator-driven IP, the genre is artistically flexible and financially durable — and one of the last truly communal experiences for Gen Z and Gen Alpha audiences. Join YouTube creator Mark Fischbach, aka Markiplier, whose independent feature Iron Lung earned more than $50 million at the global box office, Atomic Monster president Michael Clear and screenwriter Akela Cooper (M3GAN, Malignant) for a conversation moderated by Like & Subscribe’s Natalie Jarvey about why horror travels so effectively across platforms and borders, how studios and independents are building sustainable genre pipelines and why the next wave of breakout franchises may emerge from unexpected sources. Inside the Microdrama Boom Short-form serialized storytelling is having a major moment. Microdramas, social-native series and creator-led narratives are capturing massive audiences with low-cost, rapid production cycles and direct-to-fan distribution. What was once dismissed as niche or experimental is now attracting major platform investment. Moderated by Jarvey, this panel of microdrama creators and executives — including one of the format’s top stars and producers, Kasey Esser, and Dhar Mann Studios’ head of vertical content, Erin McFarlane — examines how format innovation, fandom dynamics and algorithmic discovery are reshaping the economics of scripted storytelling and what traditional studios can learn from these agile models. For sponsorship opportunities, contact Lynne@theankler.com Share
City of Santa Barbara Seeks Nominations for 2026 Business in Art Award
Credit: CourtesyCredit: Courtesy (SANTA BARBARA, Calif.) – Nominations are now open for the 2026 City of Santa Barbara Business in Art Award, which
New dispute emerges around Subnautica 2’s early access release
Lawyers for the ousted—and now partially reinstated—leadership team of Unknown Worlds, the studio behind Subnautica 2, are crying foul over news that the game will be released into early access in May. The release announcement earlier this week was made improperly, potentially “damaging the game and sowing additional confusion among the Subnautica community,” the lawyers said in a letter sent on Tuesday to Vice Chancellor Lori Will of Delaware’s Court of Chancery. In their letter, the lawyers also floated the idea of asking Will to find Krafton in contempt of the court’s ruling. The letter was sent just one day after Will’s bombshell ruling that publisher Krafton had breached its contract with Unknown Worlds’ executive team, when it fired them last June. The new issue isn’t necessarily the May early access timeframe, but how the news was announced. The letter and Krafton’s response have not been previously reported. A quick recap of prior events: Subnautica 2 is an unreleased, underwater survival adventure and the most-wishlisted game on Steam. Last year, longtime Unknown Worlds CEO Ted Gill, along with studio co-founders Charlie Cleveland and Max McGuire, were fired by Krafton. They swiftly sued, saying the publisher had terminated them to avoid paying out up to $250 million in potential performance-based bonuses. The studio leaders had hoped to earn that with an early access release of the game, which Krafton had blocked. The publisher argued in court that Subnautica 2 wasn’t ready, which the ousted execs disputed. On Monday, Will ruled that Krafton had violated its contract, firing the execs to avoid the performance payouts, and that it had to reinstate Gill and give him full authority over any early access release for Subnautica 2. On Tuesday, IGN reported on a new memo issued that day to Unknown Worlds staff by Steve Papoutsis, the executive Krafton had put in charge of Unknown Worlds after the 2025 firings. In the note, Papoutsis said that Subnautica 2 had passed a key development milestone “last week” and that he and Krafton had determined the game “is ready for Early Access release in May.” This news appeared to catch the lawyers for Gill, Cleveland and McGuire by surprise. On Tuesday night, they sent a letter to Will expressing “serious concerns” about whether it would be possible to forge an agreement with Krafton consistent with the judge’s order. Papoutsis’ memo was a problem, they wrote. He didn’t have the authority to declare anything about Subnautica 2’s release. As of 9am ET on Monday, March 16, the effective date of Will’s order, Papoutsis wasn’t CEO of Unknown Worlds. Gill was. And, per Will’s order, only Gill could make Subnautica 2 release decisions. They continued: Krafton self-servingly announced the launch without any regard to its impact on the game, the team, or the community—let alone this Court’s Opinion. Announcing the release of a game is momentous, and it is typically accompanied by significant marketing activity, fanfare, and community coordination. And most importantly, the announcement is carefully designed to maximize excitement for the game. That entire process was supposed to be driven by Mr. Gill. However, in defiance of the Court’s Opinion, Krafton has now taken that away, further damaging the game and sowing additional confusion among the Subnautica community. The lawyers speculated that Krafton had “intentionally leaked” Papoutsis’ memo and then issued an official statement to confirm the leak. Game File is a reader-supported publication. My reporting is only possible through support from readers like you. To support my work, consider becoming a free or paid subscriber. Subscribe On Wednesday, lawyers for Krafton defended their client in their own letter to vice chancellor Will, saying nothing they did violated her order nor showed contempt: Papoutsis’s message was simply celebrating the UW employees’ efforts toward a past event: Krafton’s pre-Opinion determination that Subnautica 2 was ready for Early Access release. There was nothing improper about conveying the results of the milestone review or thanking the development team for their dedication and talent. They added that Gill could still make his own call about Subnautica 2’s release: In his role as CEO, Gill will be able to assess independently his views on the state of Subnautica 2 and the appropriate release schedule; nothing in Papoutsis’s message alters Gill’s authority or discretion. Vice chancellor Will has not responded to the letters and doesn’t necessarily have to. Both parties were previously ordered by Will to confer this week and submit a proposed judgment consistent with her ruling. The letter from Gill’s attorney’s this week doesn’t indicate whether he would or would not support a May release for Subnautica 2. But it could limit his options. And, if Gill’s lawyers are right, the lack of marketing fanfare around the leak of the May date could dull the launch of the game. Any harm to Subnautica 2’s launch is an extra sensitive issue given the context of the legal dispute: millions of dollars of payouts are on the line, tethered to the scale of the game’s initial performance. In her ruling on Monday, Will noted that there was obvious “bad blood” between Gill’s side and Krafton but that the two would need to work together: “They can—and must—act in good faith to navigate their remaining contractual relationship.” Item 2: A new kind of couch co-op game A highlight of GDC each year is the Alt.Ctrl showcase that features games played with extremely experimental controllers. Perusing this year’s offerings last Friday, I found a game controlled with giant scissors, another with big toothbrushes and one that amounted to dumpster diving. My favorite was Pivot, a co-op game about collectively maneuvering a couch. It was developed by students at the University of Utah’s masters of arts and engineering games program. Players lift and tilt the physical couch in order to control the position of a virtual one. That virtual one is moving through an obstacle course on-screen, while being pursued by a giant skull. Developer Nishant Verma told me at GDC that the couch is made of styrofoam (this became more evident as I watched!) and that the name was a riff on an episode of the sitcom Friends. Item 3: In brief… 🚫 Ubisoft is laying off more than 100 workers at its Red Storm studio, as the North Carolina location known for decades for its Tom Clancy games, ceases in-house game development, VGC reports. 👀 On Monday, Nvidia’s revealed its DLSS 5 AI-driven graphics technology that purports to improve game graphics… and it has been roasted about it by the media and the online gaming public for the remainder of the week. The tech changed the faces of characters in footage from Resident Evil Requiem, Hogwarts Legacy and EA Sports FC, drawing accusations of giving carefully art-directed games the generic look of AI “slop.” Nvidia CEO Jensen Huang had said on Monday that “DLSS 5 is the GPT moment for graphics—blending handcrafted rendering with generative AI to deliver a dramatic leap in visual realism while preserving the control artists need for creative expression.” By mid-week, Huang was telling Tom’s Hardware that the new tech’s critics were “completely wrong” because game-makers could still “fine-tune the generative AI” to suit their game’s aesthetics.
Ever Joint Claims Evaluated: What the Science Says About EverJoint Joint Support Ingredients
A 2026 company-issued informational report outlining how Ever Joint positions its joint support formula, ingredient-level research context, oxidative stress claims, pricing structure, and what consumers should verify before purchasingTallmadge, Ohio, March 18, 2026 (GLOBE NEWSWIRE) -- This release is based on information provided by Ever Joint and reflects how the company describes its product, ingredients, and related scientific context. It is not an independent product review or third-party ev
Misalignment and Risk Tolerance Gaps Undermine Business Resilience, Kroll Study Finds
Kroll, the leading independent provider of global financial and risk advisory solutions, today released global cyber resilience research findings revealing a critical gap between organizations' perception of their cyber preparedness and their actual capability to defend against, and recover from, sophisticated attacks. This gap is being driven by misalignment between the C-suite and cyber decision-makers. This disconnect is costly, as organizations face a yearly average of $2.2 million in recove
Trump’s Nominee to Run NSF is Unqualified, Conflicted, and a Threat to Science
If O’Neill is confirmed as NSF’s director, the Trump administration will further tighten its control over an agency created by Congress to be independent in its work to advance science.
Federal judge blocks RFK Jr.’s vaccine policy overhaul for now
The judge said the government has undermined its history of recognizing the importance of involving independent experts in setting the national public health agenda.
Aspen Valley Health partners with electronic health record platform
Aspen Valley Health has announced the launch of an Epic Connect partnership, aiming to shift how independent rural hospitals access advanced healthcare technology in alignment with local governance.
Scientists create first-of-its-kind ‘hexagonal diamond’ harder than real thing
Material exhibits slightly higher hardness than naturally found diamond
Poll: Israel's standing plummets among Democrats, fueling primaries on the left
More registered voters view Israel negatively than positively in the latest NBC News poll, driven by change among independents and especially Democrats.
Chinese scientists create clock so precise it could redefine second
Optical clock measures time using light emitted by electrons transitioning between energy levels
Politics Unplugged Podcast: Chuck Coughlin on the SRP election
Independent consultant Chuck Coughlin returns to the pod to talk about the SRP election and why not everyone can vote. Then Dennis, Colin and Arizona's Family film critic Hunter Norris preview the Oscars.
Open-Source "GreenBoost" Driver Aims To Augment NVIDIA GPUs vRAM With System RAM & NVMe To Handle Larger LLMs
An open-source, independently developed Linux kernel module called GreenBoost aims to augment the dedicated video memory on NVIDIA discrete GPUs with system memory and NVMe storage
The Sun Sports Quiz: Winter Sports Playoff Edition
The Cornell Daily Sun - Independent Since 1880.
Seth Bodnar thinks Montana could send an independent to the Senate. Hear why
Pennsylvania researchers, parents help shape autism science as founders of new independent committee
Founders of the new Independent Autism Coordinating Committee say they will act as an alternative body to a federal advisory group under RFK Jr.
Google sells partial stake in fiber business, becomes minority owner of new venture
Google said its GFiber unit is combing with Astound Broadband and forming a independent fiber provider.
All Booked | Dragons, Shadow Daddies, and the Politics of Escapism
Ella Heydenfeldt delves into the world of today’s hottest fantasy series — and why they’re more relevant than you may be inclined to believe.
Squid Game: Unleashed dev Boss Fight Entertainment relaunches as indie studio Bossfight
Boss Fight Entertainment’s original founders have relaunched as an independent studio under a similar name. Now called Bossfight, the studio is operat...
Primary Care Is in Trouble. So Doctors Band Together To Boost Their Market Power.
Thousands of primary care practices are fighting to remain financially viable and independent. Many are banding together to form Independent Physician Associations, or IPAs, to increase their market power.
Northwestern alumni turn passion into full-time antique jewelry business
When Kasia Bogdanowicz (Weinberg ’89) retired from her career as a corporate lawyer, she turned to her passion for antique jewelry by founding Blu Dog World, a business specializing in vintage fine jewelry. Now, her company, which sells jewelry at booths and online and competes in international antique and trunk shows, is opening an independent...
Georgia Independent Wrestling’s Empire of Entertainment
“I remember just standing there that night, and I could feel this connection between the fans and the performers in a way that I hadn’t really ever felt before, which makes sense now that I know more about wrestling, because fans really have agency over the action in the ring. The louder they cheer, the more the wrestler is going to labor to his feet. Wrestling doesn’t really work without an audience,” says Athens journalist Alison Lyn Miller, who published the nonfiction book Rough House: A Father, a Son, and the Pursuit of Pro Wrestling Glory earlier this year. Miller wasn’t a wrestling fan when she attended the now-defunct Southern Violence And Wrestling match back in 2019, but her passion […]
Small business optimism slips further as sales outlook weakens
U.S. small business optimism slipped again in February as owners grew more cautious about future sales and broader economic conditions, Bloomberg writes. The National Federation of Independent Business’ optimism index edged down to 98.8, marking the second consecutive monthly decline and reflecting softening expectations across several key indicators. A major drag on sentiment was the […]
The New Brand Playbook for Unpredictable Times
Multi-brand upheaval and geopolitical uncertainty are impacting business in 2026. Here’s how independent labels are buckling down accordingly.
Out of prison, GOP strategist Tony Dane is back in Nevada politics
After resolving a legal case in Nevada and serving years in a Virginia prison, the operative is working for a congressional candidate.