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'You Can See Everything' surges with $19.5M at box office; 'Clayface' takes No. 1
DC Studios scored a modest, R-rated win with “Clayface,” landing a $24 million opening weekend, according to studio estimates Sunday.
Essentia Health hosting joint-replacement seminar in Baxter
Essentia Health hosting joint-replacement seminar in Baxter
Marcos Leonardo Opens Up On A Difficult Start At Ajax
Following Ajax's win against Atalanta, Marcos Leonardo spoke about a difficult start at Ajax.
A Look at the Cleveland Guardians' Pending Free Agents
The Cleveland Guardians have a handful of players who will hit the open market.
Open Thread World Series Game One
We get game one of the World Series tonight. I guess I’m sort of cheering for the Brewers but really it doesn’t matter. But in games three and four, Ernie Clement will be ‘providing player-first coverage’, which should be fun. Lineups: Today’s Lineups RAYS BREWERS Yandy Diaz – DH Jackson Chourio – LF Jonathan Aranda […]
5 Players Withdraw From WTA Guangzhou Open
The WTA Guangzhou Open, a WTA 250, is scheduled to take place in Guangzhou China from October 26 to November 1. WTA Guangzhou has faced a series of withdrawals ahead of the tournament, with a number of changes made to the main draw. With the tournament approaching, the main draw includes several new names, while …
Sandisk's New Business Model Is Transforming the Business. Now Is the Time to Buy the Stock.
Sandisk is entering into contractual agreements rather than just selling on the open market.
In Arkansas, Democrats see an opening at the edge of the competitive midterms map
In a sign of the potentially dire midterm political environment, Republicans have spent millions of dollars playing defense in Arkansas, one of the most conservative states in the country.
Sunday Open Thread
There is no Jays news and I’ve got nothing to talk about, so lets have an open thread. We had the second great World Series game in a row last night. I like watching baseball (or any sport) when I have no rooting interest. After a season of caring about every Jays game, I like […]
Rockets-Spurs: Thompson Block & Sengun Buckets Put Houston Back In Business
The Houston Rockets sent a message with their Friday night 114-110 win over the San Antonio Spurs. The Rockets had already won their season opener on Wednesday. But in a sign of how far expectations had fallen for Houston this season, that matchup was against the lowly Dallas Mavericks. Just two games in, expectations are …
World Series Game 2 Open Thread
The Brewers look to take a commanding lead over the back-to-back champs as the series swings to Los Angeles.
What One Extra Hour of Sleep Could Do for Your Mental Health | Hartford HealthCare
Learn more about News Detail at hartfordhealthcare.org
Trump's midterm swing brings him to Michigan as Republicans aim to undermine El-Sayed in Senate race
President Donald Trump's busy midterm campaign schedule is bringing him to Michigan, where Republicans hope to claim an open Senate seat on Election Day | Newsradio 1140 WRVA
Auburn University opens $224 million STEM+Ag science complex
Largest research construction project in school's history completed after six years of planning
Oregon’s famous Carver Cafe, featured in 'Twilight' movie series, listed for sale
Carver Cafe, known for its appearance in “Twilight,” is for sale as its owner prepares to retire, but the business says it remains open.
Blazers Look to Build on Opening Night
Fresh off a dominant rout of Phoenix, Damian Lillard and Ja Morant lead Portland into Sacramento to test their elite ball movement against a struggling Kings backcourt.
NFL Week 7 Game Discussion and Open Thread
Talk about all the Week 7 NFL games with us here!
AI tool REA cracks paid software: Is the software industry's business model coming to an end?
Videos with titles like “Clone Everything” and “How to Copy Any App” are currently drawing viewers in on YouTube. The open-source tool REA (Reverse Engineer Anything) is designed to analyze the code of any paid app, allowing AI to recreate the software from scratch. Could this disrupt the market? Here's a closer look.
New Business: Caribbean Market reopens in Manchester; Cuban ...
Caribbean Market has reopened in Manchester after a two-year rebuild, while Plymouth’s Cuba Libre has become Viva Cuba Restaurant following a trademark issue.
Texas opens as heavy favorite against Mississippi State
The Longhorns are three-score favorite as they welcome the Bulldogs to Austin.
Business Ins and Outs | Atlanta dessert shop, Provisions, Mexirican and donut shop opening
Business Ins and Outs | Atlanta dessert shop, Provisions, Mexirican and donut shop opening
Bloomington business continues to blossom
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r/opensource just banned AI, non-English speakers and more
The opensource subreddit’s new rules against AI have sparked a revolt.
Timberwolves proves size isn’t everything with historic rebounding surge
The Minnesota Timberwolves may have sacrificed size this offseason, but their first two games suggest they gained something even more valuable: relentless physicality. After reshaping their roster around speed and defensive versatility . Minnesota has opened the season with a franchise-record rebounding margin. The Timberwolves dominated the […] The post Timberwolves proves size isn’t everything with historic rebounding surge appeared first on ClutchPoints.
Three Boston Celtics Takeaways From Win vs. Knicks
The C's toppled the Knicks in the home opener at TD Garden.
SnakePit Post-season GDT, #19
The Brewers successfully held serve in the World Series opener, though it certainly got a bit tense there in the ninth inning, as Tampa had the tying run in scoring position with one out. It ended up as the 11th one-run game this post-season. That’s still a long way off the MLB postseason record for […]
Suns' Collin Gillespie describes adjustment to offseason workouts
Collin Gillespie played in 21 minutes off the bench in the Phoenix Suns loss to the Portland Trail Blazers in their opening game.
Yountville launches entertainment zone
Yountville in Napa County launched its first open container district.
HSA users can pay for prescriptions, copays and more while building long-term savings
As open enrollment season approaches, consumers reviewing their health insurance options may want to consider a health savings account, or HSA, as a way to save money on health care expenses.
Tampa General Hospital and Health Care District of Palm Beach County to Open Lakeside Cancer Center in September 2027, Expanding Access to Academic-Based Cancer Care in Florida’s Rural Communities - Florida Hospital News and Healthcare Report
Lakeside Cancer Center will connect cancer patients in the Glades with world-class treatment, complex care coordination and access to oncology specialists. October Tampa General Hospital and Health Care District of […]
Bexar County opens facility combining public health, community resources
WOAI NBC News Channel 4 San Antonio provides local news, weather forecasts, traffic updates, investigations, and items of interest in the community, sports and entertainment programming for San Antonio and nearby towns and communities in South Central Texas, including Windcrest, Uvalde, Universal City, Somerset, Seguin, Schertz, San Marcos, Sabinal, Poth, Poteet, Pleasanton, Pearsall, New Braunfels, Live Oak, Kerrville, Hondo, Helotes, Goliad, Fredericksburg, Floresville, Eagle Pass, Devine, Del Rio, Cuero, Crystal City, Converse, Cibolo, Castroville, Carrizo Springs, Boerne, Bandera.
Micron Just Revealed a New Business Strategy. That Change Makes It a Screaming Buy.
Micron is changing more toward contracts, rather than letting the open market dictate pricing.
Connecticut health insurance enrollment for 2027 opens
Access Health CT is holding one-day enrollment fairs across the state throughout October and November, with more events expected in December and January.
Latino businesses still fearful amid ICE sightings 8 months after Operation Metro Surge
A handful of new Latino eateries have opened on Payne Avenue, as others have slashed hours or remain closed certain weekdays.
Week 8 Open Thread
With no UW game this weekend, you can stay on this thread for the full weekend. Here are some of the top games to watch in each game window. Friday Evening – There are two ACC games tonight. First, Duke heads to Virginia in a fairly even matchup between teams trying to get a step […]
Watch “The Simpsons”’ spooky stop-motion “Nightmare Before Christmas” parody from ‘Treehouse of Horror’ (exclusive)
The new opening comes from Stoopid Buddy Stoodios, the stop-motion team behind “Robot Chicken.”
What Nuggets Can Learn From Season Opener Loss to Thunder
The Nuggets need to clean it up on the court.
Week 7 Early Games Open Thread
The only games I’m really keyed in on are the Steelers and Texans both losing to the NFC team and then decided which team between the Bengals and Ravens are the bigger threat to Denver’s future playoff seeding arrangement. Here are the games we have to watch today before the Denver Broncos take on the […]
Corey Lewandowski Always Found His Way Back to Trump. Until Now.
The Justice Department has opened an inquiry into Mr. Lewandowski. President Trump has not jumped to his defense.
New owners of Mount Kato plan upgrades, reassure skiers hill will stay open
New owners of Mount Kato plan upgrades, reassure skiers hill will stay open
Business Briefcase: Open-air downtown farm market continues
SHENANDOAH — Schuylkill County’s longest running seasonal outdoor downtown farm market continues its popular run 8 a.m. to noon Tuesdays and Fridays through November along the east side of the first block of South Main Street. Launched in t…
Lady Gaga dancer reveals why he thinks she’ll succeed at motherhood
Lady Gaga’s backup dancer, who slid off stage mid-performance during last year’s Mayhem Ball world tour, is opening up about why he believes the singer will succeed at motherhood.
Jamal Murray Addresses Nuggets’ Turnover Issue in Loss to Thunder
Jamal Murray speaks after the Denver Nuggets drop their season opener.
RJW Logistics to open second Northwest Arkansas office
Chicago-based RJW Logistics Group, which has a Bentonville office, plans to open an additional Northwest Arkansas office amid client growth and to support demand for a new logistics program offered...
Honeydew is betting big on the 'Hollywood dose' of Accutane
Accutane has a reputation as a drug of last resort for persistent acne. One founder is changing how it's prescribed, opening up access to mini doses.
LIVE: Palmetto Sports Team previews the Charlotte Hornets home-opener from The Hive
WATCH: Palmetto Sports’ Carmine Gemei and Caroline Soro LIVE previewing the Charlotte Hornets home-opener against the Hawks from The Hive.
Progressive Community Health Centers expands services with new pharmacy
Looking to fill a void in pharmacy access on Milwaukee’s north side, Progressive Community Health Centers will open a full-service retail pharmacy Monday
Knicks’ fatal flaw that will doom 2027 NBA championship chances
Winning back-to-back titles is one of the hardest things to do in any sport, and the New York Knicks face an intense challenge as they look to repeat. It has been almost a decade since the last time an NBA franchise won two championships in a row. While New York’s 106-100 opening night loss to the Philadelphia 76ers featured some moments that […] The post Knicks’ fatal flaw that will doom 2027 NBA championship chances appeared first on ClutchPoints.
Physician Mental Health and Health System Privacy: Why Doctors Avoid Their Own EHR
In most organizations the default access model was built for patient care, not for protecting colleagues. A nurse on another unit, a resident who rotated with them, a department administrator: any of them may technically be able to open the record, even when policy says they should not.
New Cafe 24 serves soul food with love from Erie's east side
Mom of 5 opens Cafe 24, serving up soul food takeout, delivery and catering from East Fifth Street kitchen.
Netflix’s Leadership Shake Up…Explained
(Welcome to the “Most Important Story of the Week”, my bi-weekly strategy column analyzing the most important (but often not buzziest) news story of the last two weeks. I’m the Entertainment Strategy Guy, a former streaming executive who now analyzes business strategy in the entertainment industry. Please subscribe.) Well, I had a simple article planned for this week. Called “Whoa, I Missed It!”, I’d take a gander at a few important-but-under-the-radar stories I didn’t cover while I wrote about all things “Skydance. (Formerly known as “the saga of Netflix trying to buy Warner Bros., but not Discovery, then Paramount-Skydance bought all of Warner Bros. Discovery”.) Alas, that article will have to wait. Netflix made news. Ironically, my “Whoa, I Missed It!” article would have mostly been about “content” strategy decisions, which is also what today’s article is about. But instead of the entire industry, this article will only cover Netflix’s decision to upend their film and TV content teams. Just that! So that’s the full topic of the day. I’m going to tackle the issue in the opposite direction of the way “stuff” flows: uphill. We’ll start at film, then move onto TV, and then onto the CEOs themselves, and the strategy questions that still remain. But we start with the numbers driving this. Let’s dive in. Subscribe Most Important Story of the Week - Netflix Upends Their Corporate Hierarchy I’ve got a lot of thoughts, but we’ll start with the most common response to yesterday’s article. Let’s Talk Stock Price More than one person, responding to what I published two days ago, pointed out that, well, actually, the thing driving Netflix’s actions is this: In short, stock price! Even if Netflix isn’t obsessed with their own share price—they probably are, but, for the record, my strategic advice to every CEO is to absolutely ignore stock prices, which will, ironically, probably help the stock price long-term—most everyone thinks they are. By the way, I prefer market capitalization to stock prices, because it’s a more apples-to-apples way to compare companies: But there’s an even better way to look at it, and it kinda casts some doubt on the entire push here: price-to-earnings. I have a long list of articles that I wish I had written, and chief among them is an article titled, “Am I Still a Netflix ‘Bear’?” meaning someone who thinks Netflix’s stock is overvalued. As of last summer, Netflix had solved their biggest problem—which for me (circa 2019) was the lack of free cash flow—but their stock was CRAZY overvalued. That’s this chart here: Why did Netflix’s stock price increase to a price-to-earnings ratio of 50 last summer? What financial metric changed so quickly? Nothing. Given that, historically, mature entertainment companies average 10 to 20, with 16 being the average, that increase made little sense. Netflix’s stock swoon these last eight or so months wasn’t irrational; the stock price rise last year was. So if you want a really hot Netflix take, here it is: Netflix’s stock price has been going down because the financial industry recovered its senses, not because of any strategic mistake. Yes, that would imply that cleaning house may have been a mistake. That’s why the charts yesterday are so important, because they show that Netflix did have a strategic problem (a lack of hits) and that’s what they moved to address. (One could also argue the industry drastically overrated Netflix’s growth prospects, but that’s a financial industry problem, not a Netflix strategy problem per se. Some growth estimates are just crazy. *cough* AI *cough*) Now, the last time Netflix’s stock price crashed—circa 2022—it gave them an opening. I’d argue Netflix insiders knew they needed to expand post-COVID-19 crisis, adding advertising, cracking down on password sharing, and dabbling in sports. But if they had done that when their stock price was high, it would give folks a reason to second guess their strategy. (Arguably, last year, when Netflix pursued the Warner Bros. merger, it gave the industry a chance to review their business.) Instead, after the 2022 fall, they had the opening to make strategic changes. We may see Netflix pivot again following this latest slide. For example, the “binge versus weekly” conversation is alive and well again. Same for expanding into theaters even more. And adding both linear channels and streaming bundles. And maybe more either social, user-generated, vertical, or creator content. But the first shift came with who is making the content calls. A Message from Our Sponsor Last winter Pulp Fiction was on Netflix. For those same 90 days, it was also free, with ads, on Pluto TV and the Roku Channel. That is not a glitch, and it is not rare. The title has run on 20 different US streaming services since 2019, across 80 separate windows, and for more than 600 of those days it sat on a paid subscription service and a free ad-supported one at the same time. Almost nobody can see this, because when a title leaves a service, the record that it was ever there tends to leave with it. Reelgood keeps that record, dated to the day rather than the month: 4MM+ movie, show and episode titles across 300+ services globally, with timestamped arrivals, departures and moves across SVOD, AVOD, TVOD and vMVPD. Licensing teams price against every prior window. Rights teams check what a licensee actually delivered, and when. Pick a title you think you know: data.reelgood.com/title-availability Film - Dan Lin Want to know why I don’t opine on individual film or TV executives, especially new hires? Dan Lin. As I always caution, it’s really, really, really tough to predict which executives will succeed in new roles and which won’t. The successful head of co-production/finance partner, Rideback, Lin was considered for the head of DC Studios job before taking the job as the head of Netflix. By all accounts at the time, this was a smart hire. (That’s my read of the news coverage anyways.) But now that Netflix has fired Dan Lin, we got a slew of news stories about how he was doing a terrible job. In sports media, Bryan Curtis, new Substack writer/podcaster from The Ringer, calls this the “now you tell us” story, when you only hear the bad news after a star athlete leaves a sports team. In this case, now they tell us that Dan Lin was bad with talent after he got kicked out the door. So was Dan Lin a flop? It’s actually tough to say. While film moves faster than TV, even two years isn’t really enough time to evaluate a person’s output. The new head hasn’t really taken control. As Emily Horgan noted, it takes much longer than two years to produce animated films, so yeah, it’s definitely too early to judge in that domain. As for live-action films, I just published an article by Brandon Katz called “Netflix’s Summer of Bummer”, but I’d point out Netflix had a bad summer two years ago too. Arguably, their best summer came from KPop Demon Hunters last year and Happy Gilmore 2, the latter of which I saw credited to Lin. Then, the stories came out that Dan Lin clashed with talent, both Ben Affleck and Greta Gerwig, classic “now they tell us” factoids to explain his firing. This may have been true, but also should have been expected given that he was given the mandate to bring budgets back in check, especially after Rebel Moon. So if he made folks upset, well, that’s what he was hired to do! But also, he was described as “well-liked” at his hiring! In that case, I’m a bit sympathetic to Lin, since he may have been undercut by senior leadership, as often happens. Basically, a CEO hires a subordinate to be their “bad cop” and keep budgets in check, but then when talent complains, the CEO ends up undercutting them. That’s how I think you end up with a Narnia movie as expensive as any of the other flops, along with a film executive the town no longer likes. As a result, I think that Netflix is now executing a classic “hire the opposite” move by hiring Peter Rice. This phrase comes from my experience following football and basketball coaching decisions, where teams generally hire the opposite of who they just had. If you have an offense-minded head coach, hire the defensive guy. Or in college football, if you have a strong recruiter, then you pivot to an “X’s and Os” type of guy. Or in pro basketball, if you have a very analytically minded coach, you hire the player-friendly guy. I see that here. After dropping Scott Stuber—arguably a talent-friendly executive with lax budget control—Netflix hired the business guy to keep costs in check. Now Netflix is pivoting back to Peter Rice and presumably a more talent-friendly regime. (Disney, by the way, has done this twice: hiring business guys to succeed talent-friendly Bob Iger. It didn’t work out last time.) When it comes to Peter Rice…we’ll see! Maybe he works out, but maybe he doesn’t. I’d actually say the biggest problem is that Netflix still hasn’t solved its “IP Problem”, in that they don’t own much IP, so they just have a lower hit rate. The new executive won’t solve that. (Though buying Lionsgate would help.) Share “Content” - Bela Bajaria I almost published yesterday’s article after this column, but ended up flipping the order, because it told the story so well. So if you want the data for why Netflix is looking at TV to fix their problems, it’s in that article, this graph in particular: I know I just wrote that it’s often hard to judge executives, but Bajaria ran TV for six years and film for three and a half more. That’s more than enough to judge hit rates, and Netflix needs more hits. That’s the story. Since 2023, Netflix hasn’t had as many hit shows as it used to, and many of its previous power house TV shows have ended their runs (Stranger Things most of all). Also, many shows from 2020 to 2022 probably pre-dated Bajaria’s tenure. (That said, one thing may have been outside of Bajaria’s control, which I explain below.) Let’s lump some content strategy thoughts about Netflix and TV into one place: We’re just getting started with this issue, but the rest is for paid subscribers of the Entertainment Strategy Guy, so if you’d like to find out… Why I partially blame Squid Game for Netflix’s latest troubles… What is “the football trap”... Why it might not be the TV shows or films’ fault at all… What change I don’t think Netflix will make... How Bela Bajaria evolved Netflix’s TV strategy in smart ways… Whose departure likely submarined Bajaria’s final few years… One sneaky explanation for Netflix’s content struggles... And a whole lot more... ...please subscribe! We can only keep doing this great work with your support.
Drake University students say civility comes from open-minded conversations
Drake University students involved with political student organizations discussed political civility on a panel Friday.
Orlando Science Center hosts Halloween party
Adults can enjoy an open bar, laser shows, and more at the Orlando Science Center's Halloween After Dark on October 31.
Investment driving growth at NWS Crane
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Report: Northwest Arkansas commercial real estate market remains tight
The Northwest Arkansas commercial real estate market remained tight in the office, industrial and retail sectors in the third quarter as major projects opened and new development broke ground across...
Iain Armitage says “Young Sheldon” cast drove each other ‘crazy’ while shooting season 3 opening credits
The ensemble would ‘drive each other nuts.’
'You Can See Everything' surges with $19.5M at box office; 'Clayface' takes No. 1
DC Studios scored a modest, R-rated win with “Clayface,” landing a $24 million opening weekend, according to studio estimates Sunday. But the biggest success story in theaters remained A24’s...
Boston Encourages Residents to Apply for Health Insurance during Open Enrollment Season
Friday, October 23, 2026 – Open Enrollment season begins today, October 23, 2026 and runs through January 23, 2027, and Mayor Michelle Wu, the City of Boston, and Boston Public Health Commission strongly encourage residents to take advantage of the numerous coverage options available in Massachusetts and apply for health insurance through the Massachusetts Health Connector Marketplace. For those who need help navigating
2022 Top 10 NBA Draft Pick Finds New Landing Spot While Thunder Open Two-Way By Waiving 2nd-Round Pick
Jeremy Sochan has found a new home. Sochan was selected with the No. 1 pick in the 2026 G-League Draft by the Texas Legends earlier today. The Legends, the G-League affiliate of the Dallas Mavericks, are the 2022 Top 10 draft pick's fourth franchise over the last year. Jeremy Sochan will be the No. 1 …
Apple Stores Reportedly Rolling Out New Anti-Theft System for iPhones
Bloomberg's Mark Gurman today reported that Apple is facing a growing problem where some people will buy iPhones or other products and either remove accessories from the box, open up the device and remove components, and/or remove the entire device, and then attempt to return the box hoping that the employee will not notice.
Why experts are pushing RFK Jr. to release a federal definition of ultraprocessed foods
More than 100 science, medical and nutrition experts signed and sent an open letter Friday to the Office of Management and Budget, urging the administration to release the first-ever government definition of ultraprocessed foods.
Montgomery County Precinct 4 to open new park
Montgomery County Commissioner Precinct 4 will open Granger Park in Conroe on Oct. 29 with a walking trail, children's play features and a ribbon cutting.
Katie Boulter’s Japan Open run halted after reclaiming British No 1
Katerina Siniakova, the 12-time grand slam doubles winner, will play in the 11th singles final of her career on Sunday
10 Thoughts From Watching Others Sweat It Out
Back during the very lean years of the Ray Goff era in Athens, a certain revered columnist for the Macon Telegraph joked in a weekly prediction column that Georgia would lose to “Open” during its upcoming bye week. Thankfully, those years have passed by, and the outlook for Georgia during open weeks for what is […]
Saturday football open thread
Good morning! Tottenham Hotspur Women are playing in the North London Derby today at the Tottenham Hotspur Stadium, but if you’re not into Spurs Women (weird!) or like watching other Premier League clubs other than Tottenham (super weird!) then this is the thread for you. There’s a trio of Premier League matches today, not including […]
ESMO: Roche touts ‘convincing’ phase 3 KRAS data after win over rivals
Roche has shed more light on its investigational KRAS G12C inhibitor's phase 3 victory over Amgen’s Lumakras and Bristol Myers Squibb’s Krazati. The open-label Krascendo 1 trial enrolled 338 people with previously treated KRAS G12C-mutated non-small cell lung cancer (NSCLC). Patients who had already received a KRAS G12C inhibitor or pan-KRAS/RAS inhibitor were excluded from the trial. Participants received either divarasib once daily, Lumakras once daily or Krazati twice daily. Roche announced back in July that divarasib had demonstrated statistically significant improvements in progression-free survival (PFS) and overall survival (OS), meeting the trial’s primary and key secondary endpoints. But the Swiss pharma had been holding back the detailed data until now. At the European Society for Medical Oncology (ESMO) Congress in Madrid, Roche revealed that median OS for the 167 patients who received divarasib was 17.7 months, compared to 12 months for the 171 patients who received Lumakras or Krazati. The benefit was similarly clear when it came to median PFS, which stood at 9.8 months versus 5.7 months, respectively. A total of 44% of patients receiving divarasib were alive without disease progression at one year, compared to 24% of the control group, according to Roche’s presentation. It was a similar story for the objective response rate, which came in at 58% for divarasib versus 32% for the control group, while median duration of response was 11.9 months versus 6.9 months. Stefan Frings, M.D., Ph.D., deputy chief medical officer at Roche Pharma, told Fierce that the data made for a “very comprehensive, strong package, which should be convincing to health authorities.” “It’s an important advance for patients with lung cancer,” Frings said in an interview at a Madrid hotel during the conference. “It's a second-line setting, and patients who receive divarasib benefit compared to the current first-generation KRAS G12C inhibitors by having far longer overall survival,” he continued. “They live longer. They have better progression-free survival, better response rates, and with a safety profile which is—if [anything]—even better,” he said. According to Roche, 4.8% of patients receiving divarasib discontinued treatment due to treatment-related adverse events, compared to 11.7% in the control group. Serious treatment-related adverse events were also less common with divarasib, at 7.8% versus 15.2%. Roche’s confidence in divarasib had been building even before this phase 3 success. The candidate had already shown better potency and selectivity than the incumbent KRAS G12C inhibitors Krazati and Lumakras in preclinical tests. After cross-trial comparisons suggested that the edge translated into better clinical outcomes, Roche axed a study comparing divarasib to the chemotherapy docetaxel and went toe-to-toe with Lumakras and Krazati. “We designed the drug on purpose with higher potency and better selectivity,” Frings explained. “So, based on preclinical models, we clearly knew it would be superior to the first generation.” “It’s honestly not so frequent that pharma companies go head-to-head,” he added. “But if you want to make a point, if you want to convince payers, prescribers and patients … then a head-to-head win is rather rewarding.” While Amgen and BMS reached the regulatory finish line first for KRAS G12C-mutated, locally advanced or metastatic NSCLC in 2021 and 2022, respectively, they have struggled to capitalize on their head start. Krazati brought in $55 million for BMS in the second quarter, while Lumakras delivered $111 million to Amgen. For its part, Roche is aiming for peak divarasib sales of 1 billion to 2 billion Swiss francs ($1.2 billion to $2.5 billion), according to Frings. The Big Pharma is currently recruiting patients into a phase 3 trial comparing divarasib plus Keytruda against Keytruda plus chemotherapy in previously untreated advanced or metastatic nonsquamous KRAS G12C-mutated NSCLC. Roche has previously suggested that sales in metastatic disease would account for most of the forecast. Frings was tight-lipped on the exact timeline for a regulatory filing but said the Swiss pharma is “certainly keen to get this to as many patients as possible around the world.” Roche has more RAS drugs coming up behind divarasib. The pharma has already launched phase 1 trials of a pan-RAS inhibitor called RG6505 and a KRAS G12D inhibitor dubbed RG6620 in solid tumors. Roche’s partner Chugai Pharmaceutical is also testing a pan-KRAS inhibitor called AUBE00. Roche has made a “deliberate effort” to test a range of RAS drugs, Frings said. “If you have many rare mutations and you are scrambling to find sufficient patients, a pan-RAS inhibitor makes a lot of sense,” he explained.
Texas Tech Leads 'Bad' Week 8 for Big 12 Unbeatens
The Red Raiders’ playoff dreams hit a wall in Cincinnati as sloppy play and missed opportunities ended their unbeaten run. The Big 12 race is now more open than ever after surprising finishes elsewhere.
Is it rude to keep the airplane window shades open?
In this Sunday edition of Business Insider Today, we're breaking down the flight etiquette debate that's dividing the internet.
Trump's midterm swing brings him to Michigan as Republicans aim to undermine El-Sayed in Senate race
President Donald Trump's busy midterm campaign schedule is bringing him to Michigan, where Republicans hope to claim an open Senate seat on Election Day.
Omaha Tribe opens $8.5M water treatment plant, quadrupling capacity
The Omaha Tribe of Nebraska has opened the Umóⁿhoⁿ Ní Waxúbe — Omaha Sacred Water Treatment Facility, Ní Ti, an $8.5 million plant that quadruples water storage capacity, according to utility director Jerry Henscheid. The facility came online Oct. 6 on the Omaha Reservation in northeastern Nebraska, replacing a plant built in 1980 that had […]
NFL Week 7 Sunday afternoon open thread
Join us at Buffalo Rumblings as we chat all things NFL Week 7 LIVE with like-minded folks in Bills Mafia
Crackgate? iPhone Duo Owners Report Screens Breaking Along the Hinge
Some iPhone Duos are already experiencing hinge issues that cause display cracks, based on photos shared on Reddit and the MacRumors forums. Almost all of the display faults are right along the hinge, and most result in a line of bright pixels across one side of the screen. An iPhone Duo owner in Australia said his device cracked after being opened fewer than 20 times, and there was no visible damage beforehand. Had my iPhone Duo for about six hours and had probably opened it fewer than 20 times.
Anthropic's AI Hid a Secret Message in the Stars. OpenAI's Bot Found It.
Morse code is back, baby.
Mark Allen 'completely overwhelmed' after opening up about mental health
The snooker player has given fresh hope that he may return to competition
Brewers' Biggest Winners and Losers from World Series Game 1
Jackson Chourio’s clutch hitting and William Contreras’s defensive masterclass propelled the Milwaukee Brewers to a gritty series-opening win.
Kinney Drugs offers free caregiver webinar series
Kinney Drugs will host four free caregiver webinars Oct. 28-Nov. 18 covering dementia, burnout, medication safety and caregiving tips. Registration is open.
Burnham open to 'honest discussion' on EU free movement
The PM said he wants a "factual" and "evidence-based debate" about returning to free movement between Britain and Europe.
Celebrate Halloween with Jervis Library in Rome
Jervis Public Library in Rome has announced its upcoming events for the final week in October, including being open for trick-or-treating for a book on Halloween.
Intermountain Health gets $150M for Las Vegas children’s hospital
The new hospital, slated to open in 2030, will be named in honor of Felicia and Ben Horowitz in honor of the contribution.
Iain Armitage says “Young Sheldon” cast drove each other ‘crazy’ while shooting season 3 opening credits
The ensemble would ‘drive each other nuts.’
Trump's midterm swing brings him to Michigan as Republicans aim to undermine El-Sayed in Senate race
President Donald Trump's busy midterm campaign schedule is bringing him to Michigan, where Republicans hope to claim an open Senate seat on Election Day.
U of M fellowship aims to boost rural obstetrics training and keep labor and delivery units open
The partnership is launching the new, one-year family medicine obstetrics fellowship next summer to prepare family medicine physicians to provide advanced prenatal, maternity and newborn care in rural communities. The only other fellowship of this kind in Minnesota is at Essentia Health in Duluth.
Obama compares Trump's White House renovations to 'Saddam Hussein opening a Cheesecake Factory' at Ohio rally
Barack Obama compared Trump's White House renovations to a Cheesecake Factory run by Saddam Hussein at a Cleveland rally for Ohio Democrats.
Opinion | East Asia’s cultural economies are bridging politics-driven divides
The cross-border penetration and appeal of cultural products throughout and beyond East Asia is making openings beyond traditional diplomacy.
Open Thread, Sunday, October 25: How we doing today, folks?
Your daily source for off topic chatter with the MMA Mania faithful.
IU Health’s new downtown medical campus has a name and an opening date
By Daniel Bradley | Indianapolis Business Journal
São Paulo fight back to draw away at Mirassol
Mirassol and São Paulo played out a 1–1 draw this Saturday (24) in the Brasileirão.Neto Moura opened the scoring with a header early in the game at Maião. Pedro Lima equalized for the Tricolor be...
Hornets drop home opener to Hawks in blowout fashion
The Charlotte Hornets struggled Friday night, as turnovers led to an Atlanta Hawks blowout victory at the Spectrum Center.
Cavs vs. Nets home opener game thread
The Cavs season begins in Philadelphia.
Buccaneers Start NFC South Push Against Panthers
The Buccaneers open NFC South play against the Panthers as Baker Mayfield returns from a thumb injury.
Fans surpass American Family Field capacity for World Series opener
There were more fans in attendance at American Family Field than the stadium has seats for Game 1 of the World Series.
Fastest pitch in World Series history as Brewers win opener
The Milwaukee Brewers beat the Tampa Bay Rays 3-2 in the opening game of the best-of-seven World Series as both sides aim for their first title.
New Lisbon business offering pet food and supplies
LISBON—A new business promises to provide the community with the highest quality food and supplies for their pets. The newest member of Lisbon’s business community, Pet Folk has officially opened their doors, celebrating its soft opening with a ribbon cutting and champagne Thursday. Located at 7556 state Route 45, Unit A, Pet Folk is entirely […]
Live & Local: Where to find upcoming local music, open mics and live entertainment
Rafters
Packers Star Reveals Turning Point After Brutal Start to Season
Green Bay Packers safety Evan Williams pointed to the team’s Week 3 loss to the Atlanta Falcons as the moment the defense raised its standards after an uneven start.The Packers entered that Thursday Night Football game at 1-1. They had dropped their opener to the Minnesota Vikings before beating the New York Jets in overtime. […] The post Packers Star Reveals Turning Point After Brutal Start to Season appeared first on HEAVY.