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Late Kankakee business owner honored with street renaming
Arthur E. Lax, the late owner of Lax Mortuary, had part of a street honorarily named after him by the Kankakee City Council recently.
France Politics
France's Prime Minister Sebastien Lecornu, right, France's Decentralisation Minister Francoise Gatel, left, France's Culture Minister Catherine Pegard, second left and the Mayor of Limoges Guillaume Guerin, center, listen to explanations
😂 Mystery note? BVB match-winner explains bizarre moment
Did you catch the curious scene after the final whistle in the big clash between Borussia Dortmund and Eintracht Frankfurt? Match-winner Maxi Beier suddenly found himself holding a piece of paper shor...
DOJ orders some California counties to set aside ballots from suspected noncitizens
The letters are the latest escalation in a legal battle between California and President Donald Trump's Department of Justice, which has recently focused on the state in its efforts to root out noncitizen voting ahead of the midterm elections.
Redes named RBHS Science student of the Semester
Red Bluff High School recently named fall semester science students through the first grading Oscar Redes a senior, with a GPA of 4.37 was recognized.
Nonprofit organizes ‘silkies’ hike to support military members’ mental health
Veterans, active military service members and community supporters recently gathered for a hike organized by a nonprofit dedicated to suicide prevention.
Dylan Sampson activated from IR
Browns RB Dylan Sampson back on 53-man roster after missing time with injury
Apple's $2,000 foldable iPhone reportedly cracks within hours as owners report display failures
Some early iPhone Duo buyers have reported cracked inner displays within hours of receiving Apple's $1,999 foldable smartphone. One owner claims the screen broke after fewer than 20 folds, although the extent and cause of the reported failures remain unknown.
U.S. is reducing staffing at 4 Middle East embassies over increased threats from Iran
In a memo sent Friday to Secretary of State Marco Rubio, Director of National Intelligence Jay Clayton said his teams “have received intelligence that Iran has substantially increased efforts to target U.S. personnel.”
Indiana football should be better. It also could be worse
On one hand, Indiana hasn’t played its best football in weeks. On the other, neither has anyone else, really.
Manchester United vs Bournemouth: Live updates from Old Trafford
Under-fire Manchester United manager Michael Carrick is under enormous pressure heading into today’s Premier League clash with Bournemouth on the back of a seven-game run without a win.The boss has ...
ADHD effects women differently than men, says UW Health
In recent studies, symptoms of ADHD in women are often overlooked altogether or misinterpreted as a different condition.
Science Snapshots: October 25, 2026
Three key science updates in one minute: Starry Night’s dawn matched to Jul 22, 1889; cold boosts lifespan via BH2/BH4; cluster similar-buildings cools cities.
UCLA Health expansion raises costs and concerns
UCLA Health has fast expanded its number of hospitals and number of clinics in recent years. Critics say the expansion is raising healthcare costs and question why it hasn’t included lower-income neighborhoods.
Buccaneers HC Bowles in Dubious Territory As Record Worsens
A three-game slide in fifteen games puts Todd Bowles below his predecessors’ worst marks. With star departures and close losses mounting, the struggling coach is at a crossroads.
Chris Olave targeted 10 times in Week 7
New Orleans wide receiver Chris Olave went for six receptions for 56 yards on 10 targets in Week 7
Engadget review recap: iPhone Duo, Rivian R2 and more
A roundup of recent reviews from Engadget.
UCLA Health expansion raises costs and concerns
UCLA Health has fast expanded its number of hospitals and number of clinics in recent years. Critics say the expansion is raising healthcare costs and question why it hasn’t included lower-income neighborhoods.
Juventus is limiting one of their best players
Kerim Alajbegovic was expected to receive considerably more playing time following Kenan Yildiz’s injury, which is set to keep the attacker out of action until the end of 2026. However, things have ...
New directorships provide crucial support for Vanderbilt Health’s missions
The most recent Vanderbilt Health directorships are spread throughout many departments — highlighting individuals who make an impact in myriad ways.
Browns Week 7 fantasy start-sit: Boston, Judkins, Fannin, Concepcion
Tennessee has allowed the 10th-most half-PPR points to receivers, while Dylan Sampson’s return from injured reserve threatens Quinshon Judkins’ receiving work.
Xbox Reportedly Bungled $500 Million Netflix Deal
According to industry insiders, newly appointed Xbox CEO Asha Sharma overplayed cross-media potential with recent Netflix exec Peter Rice to the tune of $800 million
South Texas Health System (@stxhealthsystem)
2 likes, 1 comments - stxhealthsystem on October 25, 2026: "One Last Chance to Think Pink: Breast cancer remains the most common cancer among women after skin cancer, making routine screenings and early detection more important than ever. Mammograms can help identify breast cancer before symptoms appear, when treatment options may be most effective. Last week, South Texas Health System McAllen celebrated breast health and preventive care with a special Mammo Monday event featuring the vibrant sounds of mariachi music at the hospital’s main entrance. The celebration reflected STHS' ongoing commitment to encouraging women to prioritize their health through regular screenings. Now, there’s one final Mammo Monday remaining! Join us at STHS ER Mission on October 26 from 8 a.m. to 5 p.m. for the last breast cancer event of 2026. During the event, attendees can: 🎀 Learn about breast cancer screening options 🎀 Schedule a mammogram appointment 🎀 Receive a complimentary goodie bag while supplies last To help make preventive care more accessible, South Texas Health System is also offering reduced self-pay rates* throughout October: • 2D Mammogram: $100 • 3D Mammogram: $155 • Bone Density Screening: $160 A screening today could make all the difference tomorrow. Make your health a priority and encourage the women you love to do the same. For breast health resources and information on the Think Pink campaign, visit the link in our bio. *If not already a covered benefit of your insurance.".
Celebrate Halloween with Jervis Library in Rome
Jervis Public Library in Rome has announced its upcoming events for the final week in October, including being open for trick-or-treating for a book on Halloween.
Tiger Woods Comeback Buzz Grows As December Return Takes Shape
Tiger Woods fuels fresh comeback speculation after a promising practice session, with the Hero World Challenge and PNC Championship emerging as possible return dates.
Untreated sewage contaminates San Juan River as floodwaters threaten public health
Untreated sewage has entered the flooded San Juan River, Navajo Nation officials said Saturday, warning that contamination could remain long after the water recedes.
Christina Applegate misdiagnosis: Why can MS be difficult to diagnose?
MS advocate Christina Applegate recently announced that her MS diagnosis was incorrect, based on new test results. Why can the disease be difficult to identify?
Nico Williams publicly disavows his agent over Barcelona transfer claims
Barcelona’s long and drawn-out pursuit of Nico Williams has become one of the more familiar sagas of recent transfer windows.The Athletic Club winger ultimately opted to stay at San Mames, snubbing ...
I bought a house in Japan at 23 with 7 college friends for under $20k
A recent college graduate teamed with friends to buy and renovate an abandoned home in Hiroshima, Japan. They're using it as an escape from city life.
Alabama’s Receiver Rotation Raises a Bigger Question for Ryan Grubb
Crimson Tide wide receiver Noah Rogers waited almost the entire devastating loss at Tennessee from the sideline. The NC State transfer, who played two snaps in Knoxville, and Keelon Russell, who never threw a pass his way. Alabama’s leading receiver, Ryan Coleman-Williams, missed the game after reportedly having knee surgery, so the door looked wide …
Breece Hall questionable for Week 7
Breece Hall's status will need to be watched by fantasy players ahead of Week 7.
Skip Bayless Has Bold Vikings Declaration After Bears Win
Skip Bayless doubled down on his belief that the Minnesota Vikings will win the NFC North despite the Chicago Bears’ recent victory, keeping the division race firmly in the spotlight. The outspoken sports commentator’s prediction signals that he remains confident in Minnesota’s chances as the NFC North contenders continue to battle for position. The Bears’ […] The post Skip Bayless Has Bold Vikings Declaration After Bears Win appeared first on Gridiron Heroics.
Middleburg High School volleyball stays on track in FHSAA playoffs
A recent champion advanced and a 21-season streak ended in Saturday's FHSAA high school volleyball playoffs in Northeast Florida.
Phibro Animal Health (PAHC) Stock May Still Offer Value At This Price
Phibro Animal Health has seen its share price move around in recent years, and that raises a straightforward question for investors who focus on fundamentals. Is the current US$38.80 price tag adequately supported by the earnings the company is generating today? Over the past 3 years the stock has delivered a very large gain of 284.1%, which puts real pressure on the question of whether current earnings can carry that kind of re-rating. The business model is tied closely to recurring demand...
Obama, in Midwest, assails 'cruelty' and indecency from Trump and his allies in the midterm campaign
Obama remains the Democratic Party’s best motivator nearly a decade after leaving the White House. And he's taking his star power on the road in the final days of the midterm elections, which will help determine the balance of power in American politics on Nov. 3.
Intermountain Health Receives One of the Nation’s Largest Gifts in Pediatric Care
LAS VEGAS — Intermountain Foundation announced today that Nevada’s first stand-alone children’s hospital will be named Intermountain Health Felicia and Ben Horowitz Children’s Hospital in honor of a historic $150 million commitment. Felicia Horowitz, president of the Horowitz Family Foundation and co-founder and president of The Paid ...
Hibernian vs Celtic – Match preview and team news
Celtic will look to bounce back from their recent European defeat as they travel away from home to face Hibernian in their next Scottish Premiership match on Sunday.Hibernian vs Celtic – Match prev...
🥈 Bullet header places Antoine Griezmann in MLS goalscoring pantheon
Antoine Griezmann's arrival in MLS has come up with the goods in expected fashion across much of the 2026 season, with the World Cup winner and France icon becoming one of the faces of the league and ...
Islanders Gameday News: Starting in Dallas; Hellebuyck moves next door
The Islanders have touched down in Dallas for a Sunday night encounter, where Pete DeBoer will be the story as he faces his most recent former team. The Stars are in their 1980s Capitals era (or more generously, 1980s Flyers), perennially fielding really good teams but finding different reasons and divine interventions to prevent their […]
Liverpool and Man United contacted about transfer of wonderkid
Liverpool have a fair few positions among their ranks that still need to be upgraded. The Anfield outfit have fallen behind their title rivals quite dramatically recently with most of their players fa...
Addressing mental health and loneliness through art: LaunchSpace's SocialRx program gets United Way funding support
LaunchSpace's SocialRx program received a $75,000 grant from the United Way of Franklin & Hampshire Region to boost regional wellness.
Family Health Insurance Now Costs $28,303 — But Workers at Small Companies Pay 42% More
Americans have grown accustomed to watching their paychecks shrink under the weight of rising expenses. Groceries cost more, housing consumes a larger share of household income, and utility bills keep climbing. Yet one of the biggest financial burdens is often deducted before workers even receive their paychecks: health insurance. Unlike a trip to the supermarket, […]
Two Colts players receiving trade interest
Colts OG Quenton Nelson, DT DeForest Buckner are trade targets for teams leading up to deadline
Steve Kerr accuses Grizzlies of flopping after Warriors loss
Steve Kerr accuses Grizzlies of flopping after Warriors loss
Misery Index: Texas Tech's big money and bigger talk can't save it from embarrassing loss
Pols & Politics: Questions raised in recent polling on Gov’s race as RNC survey shows tight matchup
Recent polls on the upcoming race for Massachusetts Governor, which showed double-digit leads for Gov. Maura Healey over GOP challenger Mike Minogue, have raised questions on their methodology.
'I miss him.' Lakers reunite with Rui Hachimura in first game against Clippers
Rui Hachimura, who signed with the Clippers in the offseason, received a warm welcome from Austin Reaves and Luka Doncic before the Clippers' loss to the Lakers.
Guest opinion: Partisan politics don’t belong in Montana’s courtrooms
As retired district court judges who worked in courtrooms across Montana, we know there is no Democratic or Republican way to handle the everyday court cases Montanans face. That’s why we support Constitutional Initiative 132 to keep our judicial elections nonpartisan.
Think local first, our businesses need us
At a recent Good Morning Galveston meeting, I asked our members a simple question: How many of you expect to still be in business next year?
Dear Abby | Disliked dad's daughter receives no condolences
Dear Abby: A friend's wife's elderly biological father was killed in a one-car auto accident recently. She had been estranged from him for as long as I can remember (more
Connections: Law firms hire attorneys for NWA offices
Two Little Rock-based law firms have hired attorneys for their Northwest Arkansas offices, and the Single Parent Scholarship Fund of Northwest Arkansas recently announced new board members. NEW HIRES Banking...
Amorim eyes raid on Manchester United for £52m defender
Ruben Amorim is keen on a reunion with Manchester United defender Leny Yoro at AC Milan.The Serie A side are weighing up a move for the 20-year-old at the end of the season, according to reports in It...
FAU star receiver achieves historic feat with 5-TD performance
The FAU Owls set themselves apart in college football history following a spectacular performance from Easton Messer in their 51-49 win over the Rice Owls on Saturday afternoon. Messer is going through the final season of his collegiate career, his second with the Owls. He shines as one of the best receivers in the nation, ranking high with a lot […] The post FAU star receiver achieves historic feat with 5-TD performance appeared first on ClutchPoints.
Not sure who to vote for? Here are the main political parties ahead of Israeli elections
From Netanyahu’s Likud to Eisenkot’s Yashar and Winter’s Amcha Israel, the contenders differ on security, military service, religion and the courts
Los Angeles health authorities report 2nd second rabies-positive raccoon
In a follow-up on the report a rabies-positive raccoon found in Los Angeles County, the first in more than 5 decades, the LA County Department of Public Health is investigating a second rabies-positive raccoon found in the Westlake Village area of Los Angeles County. Public Health has confirmed that the first raccoon was positive for a variant of rabies typically found in bats. Strain testing for the second raccoon is currently pending. The second rabid raccoon was found in a backyard in the vicinity of where the first raccoon was reported and appeared sick and aggressive. No residents or pets were exposed to the raccoon. Two people at a worksite may have been exposed to the raccoon and are receiving recommended follow-up for rabies post-exposure prophylaxis. The World’s Deadliest Viruses Prior to these detections, the last confirmed rabid raccoon in Los Angeles County was detected in 1973, when the skunk variant (strain) of rabies was still present in the County. That strain has not been detected in Los Angeles County since 1979. In 2014, a skunk infected with the bat variant of rabies was detected in Long Beach. “The detection of rabies in another raccoon is an important reminder to never touch, handle, or feed any wild animals, even when they appear healthy,” said Muntu Davis, MD, MPH, Los Angeles County Health Officer. “Always keep a safe distance from wildlife and contact your local animal control if you encounter an animal that appears to be sick, injured, or behaving unusually. It is also critical to ensure your pets are up to date on rabies vaccination so they are protected before any potential exposure. Keeping your pets vaccinated is one of the most important steps you can take to protect your entire family.” Outbreak News Today is a reader-supported publication. To receive new posts and support my work, consider becoming a free or paid subscriber. Subscribe
A woman owned small business opportunity through a popular Valley farmer’s market
Among the rows and rows of homemade items and other one-of-a-kind creations found at the Pinnacle Peak Farmers Market, woman owned business proprietor, Tara J. Harley offers something shoppers have a difficult time finding: handmade jewelry where every piece a unique creation. Harley, owner of Lady J’s Creations, designs unique handmade jewelry and brings her...
Former Minecraft lead, Xbox veteran and COO Helen Chiang "fired" for "policy violations"
A new report suggests that Helen Chiang, recently appointed as Xbox Chief Operations Officer, was terminated for "policy violations," although there's no word on exactly what.
Browns Star Denzel Ward Drops 2-Word Message on Injury
Denzel Ward offered a two-word update after a late-week hand injury, as the Browns received encouraging news on several other key defenders. The post Browns Star Denzel Ward Drops 2-Word Message on Injury appeared first on HEAVY.
States are forcing hospitals to offer more people financial aid. In Oregon, it’s working.
Four years ago, Oregon hospitals were under fire from state authorities and patient advocates. Hospitals, critics said, had made it too hard for patients to apply for and receive help paying their bills. Within months, the state enacted a sweeping law that required hospitals to proactively screen patients and give financial aid to those who […]
Helen Mirren receives Legend of Entertainment Award at SCAD Savannah Film Festival
Helen Mirren receives Legend of Entertainment Award at SCAD Savannah Film Festival
Clatsop County health inspections for September
Clatsop County health inspectors recently completed a round of restaurant inspections that yielded overwhelmingly positive results for most local eateries. But one Seaside establishment received a temporary closure after receiving […]
Columbus CEO Celebrates Our 2026 Best of Business Awards Winners
Columbus CEO honored the 85 winners of our 19th annual Best of Business awards on Oct. 14. The reception, held at Vitria on the Square in Columbus, drew more than 180 guests and included networking, a panel discussion and an awards ceremony.
Memorial Health System receives donations for mobile health unit
Memorial Health System is giving a big thanks to the Population Health Department’s auxiliary unit for donating a defib and two body mass index monitors to the mobile health unit. These items enhance the ability to provide safe, high-quality care in the communities served. The defib will provide tools to respond effectively during medical emergencies in the field. The BMI...
Bengals News: Andrew Hawkins Weighs in on Bengals vs. Ravens
The former Bengals receiver and current NFL analyst has some thoughts on Sunday’s big matchup.
The educational divide could spell trouble for Republicans
Republicans tend to run better among voters without a college degree than those with one, which has battered Democrats in recent presidential elections. But that same pattern could give Democrats a potentially decisive boost in next month’s midterms.
Union to Dedicate Historic Marker Commemorating Battle of Connecticut Farms as Part of America's 250th Celebrations
Union – The Township of Union Planning Committee for the 250th Anniversary of the United States, in partnership with the Union Township Historical Society, invites residents and history enthusiasts...
CVS Health (CVS) Stock May Be Undervalued Despite Opioid Settlement
CVS Health has delivered solid gains over the past few years, and recent headlines have kept the company firmly in focus. With the stock around US$93, the question for you is whether that price is well supported by the earnings CVS generates today. Over the past 3 years CVS Health has returned 57.9%, which puts real weight on whether current earnings can shoulder the higher valuation investors are now paying. The US$315 million opioid settlement and related compliance upgrades may affect...
TJPDC announces rural health program funding
CHARLOTTESVILLE, Va. (CBS19 NEWS) -- The Thomas Jefferson Planning District Commission has been selected to receive an $11.8M award to bring healthcare closer to rural residents.
“We Have No Business up There” – Gattuso Insists Lazio Are Targeting 40 Points
Gennaro Gattuso urges Lazio to keep their feet on the ground and focus on modest objectives despite leading the Serie A table.Lazio Overcome Parma TestThe Biancocelesti raised their tally to 22 from a...
Rumored Lucia Actress Goes Viral After Dodging Swarm of GTA 6 Comments During Livestream
Manni L. Perez, the actress long rumored to be playing Lucia in GTA 6, has gone viral after dodging a swarm of comments from Grand Theft Auto fans during a recent livestream.
When a teen posts a selfie, how much filter is 'too much' filter?
The recent Meta settlement includes a clause banning "cosmetic procedure filters" for teens. But defining what constitutes an extreme makeover isn't easy.
France Politics
France's Prime Minister Sebastien Lecornu, right, and France's Urbanity and Decentralisation Minister Francoise Gatel attend a visit at a police station in the context of security and reconstruction efforts after
Real Madrid boss Jose Mourinho sends DEFIANT Lamine Yamal message ahead of El Clasico
Real Madrid manager Jose Mourinho insists his side will not alter their tactical approach to deal with Barcelona sensation Lamine Yamal in Sunday's massive Liga fixture. The Portuguese coach dismissed his team's recent thrashings of Sevilla and RB Leipzig, declaring that previous form means nothing during El Clasico.
Titans $74 Million WR Tabbed Trade Candidate Before Week 7
A member of the Tennessee Titans wide receiver room is tabbed as a potential trade candidate by an NFL writer The post Titans $74 Million WR Tabbed Trade Candidate Before Week 7 appeared first on HEAVY.
Bayern Munich insiders raised red flags over 'workaholic' Vincent Kompany's health weeks before training ground collapse
New reports have emerged suggesting that senior figures at Bayern Munich were increasingly concerned about Vincent Kompany’s health and lack of work-life balance weeks before his recent collapse. The former Manchester City captain was rushed to hospital after falling ill while observing a reserve team training session, leaving those present at the Sabener Strasse facility deeply shaken.
Local breakfast chain plans Derby expansion
The Easy Egg, a Wichita-based breakfast and lunch restaurant, recently announced plans to expand into Derby. Reports indicate the local chain will take over the space at 317 N. Rock
Latest Karl-Anthony Towns Update is Good News For Warriors
The Golden State Warriors need to find creative routes to improve the roster with Stephen Curry starting to hit the late chapters of his career. NBA pundits have started to question whether the New York Knicks will retain Karl-Anthony Towns. Recent reports have shown Towns and the Knicks far apart on the extension talks of […] The post Latest Karl-Anthony Towns Update is Good News For Warriors appeared first on HEAVY.
New York state woman charged with voting illegally says she recently learned she wasn’t a citizen
Marva Cook was adopted as a toddler and had always assumed she was a U.S. citizen, she told Homeland Security investigators earlier this month, according to the criminal complaint.
Omarion Hampton Receives Favorable Ranking Among Sophomore Running Backs
Los Angeles Chargers running back Omarion Hampton receives a favorable ranking when compared to the rest of the sophomore running backs in the NFL.
TST Best Bets: October 24, 2026
A full week later, it’s still hard to wrap my head around what we witnessed in college football last week.In unprecedented fashion, five of the top seven nationally ranked teams lost outright, throwing the sport’s balance of power into disarray.A lesser gambler might want to stay away from college football this week until things settle down, but we remain undaunted.For all of your college football betting picks, here are today’s TST Best Bets, brought to you by BetOnline.ag. Click here to join.
One Underrated Timberwolves Wing Gets High Praise From Chris Finch
Terrence Shannon Jr. is shaping up to be one of the Timberwolves' sneakiest threats.
Which States Are Smelliest, Hottest, And Stupidest
In recent research, the AI model had wild answers about where the sexiest and ugliest Americans live, too.
City make four changes for trip to Aston Villa
City make four changes for Saturday’s return to Premier League action away at Aston Villa. Men's Team One Moment in Time: Distin's wonder goal at Villa Park Erling Haaland, Marc Guéhi, Jérémy Dok...
Austin Hedges’ Future With the Guardians Appears Uncertain
Austin Hedges has been an important piece of the Cleveland Guardians roster for the last half-decade, but there's no guarantee he's back in 2027.
Wrexham’s Summer Striker Decision Faces Fresh Scrutiny After Blackburn Defeat
Wrexham’s decision to back their current centre-forwards has become a renewed talking point after Saturday’s 2–0 defeat at Blackburn Rovers exposed the gap between attacking activity and a meaningful goal threat.
Why Mikel Arteta is right about Max Dowman
Mikel Arteta has faced some pushback on his recent comments about Max Dowman, but the Arsenal manager was right to suggest that what the 16-year-old is doing is unique.Photo by Julian Finney/Getty Ima...
Penn State men's basketball player profile: Jay Rodgers, Guard
Penn State basketball is getting ready to take the court once again, so here’s a look at new guard Jay Rodgers.
Lakers 1st-Round Draft Pick Floated as Trade Piece
The Los Angeles Lakers are off to a fast start. Could it be time to weigh trading away some young pieces to boost the rotation? The post Lakers 1st-Round Draft Pick Floated as Trade Piece appeared first on HEAVY.
Nebraska volleyball vs. USC live updates, stats and highlights
Nebraska hosts USC in a Big Ten volleyball match on Saturday night. The Huskers are undefeated through 20 games for the 10th time in program history.
Forget shopping for gifts — receiving them is stressing us out
Experts offer tips on how to manage the feelings of disappointment, guilt or anxiety when you get a bad or inappropriate present.
LETTER TO THE EDITOR: Misleading political mailer is a smear campaign
The recent misleading smear mailer by the opponents of Denise Krause in the Oregon Senate campaign is the most disgusting exhibit of money and indecency used to capture uninformed voters’ […]
The Locations of North Carolina’s Industrial Poultry Farms Have Been a Secret—Until Now
A few days before Christmas in 2023, the U.S. Environmental Protection Agency received a complaint through its National Response Center: “There has been a horrible smell in the air for almost a week,” the caller said, according to state records. “It’s so bad it’s making people throw up.” The caller thought the odor was emanating […]
France Politics
France's Culture Minister Catherine Pegard, France's Trade Minister Serge Papin, France's Prime Minister Sebastien Lecornu, Mayor of Limoges Guillaume Guerin and France's Decentralisation Minister Francoise Gatel walk during a visit
ESMO: Roche touts ‘convincing’ phase 3 KRAS data after win over rivals
Roche has shed more light on its investigational KRAS G12C inhibitor's phase 3 victory over Amgen’s Lumakras and Bristol Myers Squibb’s Krazati. The open-label Krascendo 1 trial enrolled 338 people with previously treated KRAS G12C-mutated non-small cell lung cancer (NSCLC). Patients who had already received a KRAS G12C inhibitor or pan-KRAS/RAS inhibitor were excluded from the trial. Participants received either divarasib once daily, Lumakras once daily or Krazati twice daily. Roche announced back in July that divarasib had demonstrated statistically significant improvements in progression-free survival (PFS) and overall survival (OS), meeting the trial’s primary and key secondary endpoints. But the Swiss pharma had been holding back the detailed data until now. At the European Society for Medical Oncology (ESMO) Congress in Madrid, Roche revealed that median OS for the 167 patients who received divarasib was 17.7 months, compared to 12 months for the 171 patients who received Lumakras or Krazati. The benefit was similarly clear when it came to median PFS, which stood at 9.8 months versus 5.7 months, respectively. A total of 44% of patients receiving divarasib were alive without disease progression at one year, compared to 24% of the control group, according to Roche’s presentation. It was a similar story for the objective response rate, which came in at 58% for divarasib versus 32% for the control group, while median duration of response was 11.9 months versus 6.9 months. Stefan Frings, M.D., Ph.D., deputy chief medical officer at Roche Pharma, told Fierce that the data made for a “very comprehensive, strong package, which should be convincing to health authorities.” “It’s an important advance for patients with lung cancer,” Frings said in an interview at a Madrid hotel during the conference. “It's a second-line setting, and patients who receive divarasib benefit compared to the current first-generation KRAS G12C inhibitors by having far longer overall survival,” he continued. “They live longer. They have better progression-free survival, better response rates, and with a safety profile which is—if [anything]—even better,” he said. According to Roche, 4.8% of patients receiving divarasib discontinued treatment due to treatment-related adverse events, compared to 11.7% in the control group. Serious treatment-related adverse events were also less common with divarasib, at 7.8% versus 15.2%. Roche’s confidence in divarasib had been building even before this phase 3 success. The candidate had already shown better potency and selectivity than the incumbent KRAS G12C inhibitors Krazati and Lumakras in preclinical tests. After cross-trial comparisons suggested that the edge translated into better clinical outcomes, Roche axed a study comparing divarasib to the chemotherapy docetaxel and went toe-to-toe with Lumakras and Krazati. “We designed the drug on purpose with higher potency and better selectivity,” Frings explained. “So, based on preclinical models, we clearly knew it would be superior to the first generation.” “It’s honestly not so frequent that pharma companies go head-to-head,” he added. “But if you want to make a point, if you want to convince payers, prescribers and patients … then a head-to-head win is rather rewarding.” While Amgen and BMS reached the regulatory finish line first for KRAS G12C-mutated, locally advanced or metastatic NSCLC in 2021 and 2022, respectively, they have struggled to capitalize on their head start. Krazati brought in $55 million for BMS in the second quarter, while Lumakras delivered $111 million to Amgen. For its part, Roche is aiming for peak divarasib sales of 1 billion to 2 billion Swiss francs ($1.2 billion to $2.5 billion), according to Frings. The Big Pharma is currently recruiting patients into a phase 3 trial comparing divarasib plus Keytruda against Keytruda plus chemotherapy in previously untreated advanced or metastatic nonsquamous KRAS G12C-mutated NSCLC. Roche has previously suggested that sales in metastatic disease would account for most of the forecast. Frings was tight-lipped on the exact timeline for a regulatory filing but said the Swiss pharma is “certainly keen to get this to as many patients as possible around the world.” Roche has more RAS drugs coming up behind divarasib. The pharma has already launched phase 1 trials of a pan-RAS inhibitor called RG6505 and a KRAS G12D inhibitor dubbed RG6620 in solid tumors. Roche’s partner Chugai Pharmaceutical is also testing a pan-KRAS inhibitor called AUBE00. Roche has made a “deliberate effort” to test a range of RAS drugs, Frings said. “If you have many rare mutations and you are scrambling to find sufficient patients, a pan-RAS inhibitor makes a lot of sense,” he explained.
Buccaneers vs. Panthers Week 7 inactives: Baker Mayfield returns
The Tampa Bay Buccaneers are set to take on the Carolina Panthers Sunday afternoon in a crucial NFC South matchup at Bank of America Stadium in Charlotte. Tampa Bay received some encouraging news ahead of kickoff as quarterback Baker Mayfield is officially active and will start after missing the previous three games with a dislocated […]
Tom Arnold defends Roseanne Barr from Chuck Lorre’s claim she ‘hated’ her show’s writers: ‘She only liked the funny ones’
Lorre’s memoir, “Sitcom,” has ignited a firestorm of controversy that shows no signs of slowing down.
Q+A: How this private equity group raised $1.3 billion investing in fr
Doug Kennealey, co-founder of Princeton Equity Group, said franchises are "phenomenal" and "cash-rich" business models. The firm secured $1.3 billion in two months for its most recent fund.
Senator, former California Secretary of State Alex Padilla weighs in on voter roll fight
With one week left before the midterm elections, California is facing a federal lawsuit alleging that non-citizens were registered to vote, received mail-in ballots, and, in some cases, voted.