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Tractor-trailer crash closes part of US-70W Business
Two lanes are closed on US-70W Business after a crash involving a tractor-trailer.
Ramaswamy ad puts Acton’s estranged mother in spotlight as records reveal family’s troubled past
Vivek Ramaswamy faces bipartisan backlash over an ad featuring Amy Acton’s estranged mother, whose rocky history emerges in court records and interviews.
Obama describes Trump as an agent of ‘chaos and cruelty’ in midterm elections pitch
The former president on Saturday also criticized Republican Vivek Ramaswamy’s attack ad featuring the estranged mother of Amy Acton, his Democratic rival for governor.
I'm 62 and refuse to dress or act my age
Lonni Pike got sober at 51 and reinvented her life. Now 62, she's a fashion influencer, gamer, and advocate for aging on her own terms.
New evidence suggests spinosaurus spent most of its life underwater
Millions of years after animals first conquered land, some took an extraordinary evolutionary U-turn and returned to the water. Using machine learning and thousands of fossil measurements, Yale scientists have uncovered surprising clues about which prehistoric creatures truly became aquatic. Their findings suggest that Spinosaurus spent most of its life underwater, while some ancient marine reptiles previously thought to be fully aquatic actually spent considerable time on land.
What gets fact-checked? How politics shapes the answer in four African countries
Many fact-checkers are moving away from declaring claims as true or false, and trying to help people judge information for themselves.
Former Minecraft lead, Xbox veteran and COO Helen Chiang "fired" for "policy violations"
A new report suggests that Helen Chiang, recently appointed as Xbox Chief Operations Officer, was terminated for "policy violations," although there's no word on exactly what.
An electronic health record tool for exercise prescription may reduce fall rate among older adults
In a large randomized clinical trial among 22 primary care practices, use of an electronic health record-integrated clinical decision support tool known as…
Will the Brewers lose again this year?
Milwaukee is cooking, y’all. After winning 103 regular season games, they blew through the Padres in the Division Series, swept the Dodgers in 4 games in the Championship Series and currently have a 2-0 lead in the World Series. They’re 5-1 in one-run games, so they’re not exactly blowing teams out. But with their bullpen […]
Brian Branch set to make season debut in Week 7
Lions S Brian Branch will make his 2026 debut as the team is expected to activate him from PUP
After long, strange trip, Compass CEO nears launch of psilocybin pill
Compass Pathways is on the cusp of FDA approval for a proprietary version of psilocybin — the active drug in magic mushrooms.
Gyökeres May Not Be Scoring, But He’s Helping Arsenal Win
Viktor Gyökeres is still waiting for his first Premier League goal of the season, and for a striker of his reputation, that’s always going to attract attention.But are we becoming too focused on wh...
Bloomington business continues to blossom
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Voters in 2 Democratic strongholds could ban transgender girls from girls school sports
Colorado and Washington are reliably Democratic states where elected officials have rejected moves to ban transgender women and girls from female sports competitions. Now activists have gone around lawmakers to put proposed bans on both states’ ballots.
Instacart Stock What Health Benefits Deal And $5 Million Settlement Mean
Instacart parent Maplebear has agreed to a US$5,000,000 settlement with U.S. authorities over past PERM hiring practices and has been selected by True Rx Health Strategists to power an employer funded healthy food benefit through Instacart Health Fresh Funds starting in 2027. The True Rx program positions Instacart within pharmacy benefit design and ties employer spend directly to clinically supervised food choices. The settlement adds compliance obligations, policy changes and monitoring...
Week 7 inactives for Saints
New Orleans declares seven players inactive versus Pittsburgh
Seattle Mariners Rumors: Zach Neto Gaining Traction as Possible Target
The M's certainly have a need for what Neto can provide.
GO Health asks families to be lead-aware
BATAVIA — Area health departments are encouraging families to get the facts and get their children and homes tested for National Lead Poisoning Prevention Week.
Business co-owner kills man ‘acting irrationally’ outside Zumba class, NC police say
The business co-owner was carrying a firearm, Spindale police say.
Vikings planning big Jordan Mason decision ahead of Week 7
The Minnesota Vikings plan to activate running back Jordan Mason from injured reserve ahead of Sunday’s Week 7 matchup against the Indianapolis Colts , provided everything goes well Saturday. ESPN’s Jeremy Fowler reported Saturday via X, formerly known as Twitter, that Minnesota expects to bring Mason back after a four-game absence. “Vikings plan […] The post Vikings planning big Jordan Mason decision ahead of Week 7 appeared first on ClutchPoints.
Packers activate Josh Jacobs
Packers running back Josh Jacobs is set to make his first appearance of the 2026 season.
Juventus is limiting one of their best players
Kerim Alajbegovic was expected to receive considerably more playing time following Kenan Yildiz’s injury, which is set to keep the attacker out of action until the end of 2026. However, things have ...
Three giant black holes discovered in a galaxy from the dawn of time
Astronomers have discovered three actively feeding black holes inside a single galaxy more than 12.5 billion light-years away, revealing a remarkable scene from the universe’s infancy. Two of the black holes are separated by just 620 light-years and are expected to eventually merge, while a third lurks farther away. One weighs an astonishing 80 million suns, and another is growing faster than conventional theories predict.
ClicData Launches MCP Server to Bring Trusted Business Data to AI Assistants for Midmarket Teams
Every query runs inside existing ClicData permissions, security protocols, and audit trails, so AI tools reach only data a user is authorized to see.
Micron Just Revealed a New Business Strategy. That Change Makes It a Screaming Buy.
Micron is changing more toward contracts, rather than letting the open market dictate pricing.
Dylan Sampson activated from IR
Browns RB Dylan Sampson back on 53-man roster after missing time with injury
Appleton-area high school sports results for Saturday, Oct. 24
High school tennis, volleyball, soccer and cross-country teams were in action.
Nonprofit organizes ‘silkies’ hike to support military members’ mental health
Veterans, active military service members and community supporters recently gathered for a hike organized by a nonprofit dedicated to suicide prevention.
Week 7 inactives for Ravens
Baltimore declares five players inactive versus Cincinnati
Kalel Mullings, K.J. Osborn elevated to play in Week 7
Titans RB Kalel Mullings, WR K.J. Osborn recalled from practice squad for Week 7's game against the Browns
How to watch every ‘Rambo’ movie in order, from ‘First Blood’ to ‘Last Blood’
The ‘Rambo’ franchise spans five movies and more than 40 years, with a prequel on the way in 2027. Revisit Sylvester Stallone’s action-packed saga, from ‘First Blood’ to ‘Last Blood.’
Demichelis' Gamble Pays Off As Leipzig Crush Elversberg 4-0
After a tactical reshuffle, the Red Bulls maintained their flawless home record as Rômulo’s clinical double and Christoph Baumgartner’s emotional return ignited a dominant four-goal second-half blitz.
DeVonta Smith out for Week 7
Eagles WR DeVonta Smith won't play in Week 7 after not practicing all week
Union County Best of the Best Business of the Year Magnolia Renovations Joshua Andrews, owner
What was your reaction when you learned your business had been named Business of the Year?
Liverpool 2, Brighton 0 – Match Recap: That Was Actually Fun
A look back at the key moments in Liverpool's great victory over Brighton in Premier League action.
Buccaneers vs. Panthers Week 7 inactives: Baker Mayfield returns
The Tampa Bay Buccaneers are set to take on the Carolina Panthers Sunday afternoon in a crucial NFC South matchup at Bank of America Stadium in Charlotte. Tampa Bay received some encouraging news ahead of kickoff as quarterback Baker Mayfield is officially active and will start after missing the previous three games with a dislocated […]
Netflix’s Leadership Shake Up…Explained
(Welcome to the “Most Important Story of the Week”, my bi-weekly strategy column analyzing the most important (but often not buzziest) news story of the last two weeks. I’m the Entertainment Strategy Guy, a former streaming executive who now analyzes business strategy in the entertainment industry. Please subscribe.) Well, I had a simple article planned for this week. Called “Whoa, I Missed It!”, I’d take a gander at a few important-but-under-the-radar stories I didn’t cover while I wrote about all things “Skydance. (Formerly known as “the saga of Netflix trying to buy Warner Bros., but not Discovery, then Paramount-Skydance bought all of Warner Bros. Discovery”.) Alas, that article will have to wait. Netflix made news. Ironically, my “Whoa, I Missed It!” article would have mostly been about “content” strategy decisions, which is also what today’s article is about. But instead of the entire industry, this article will only cover Netflix’s decision to upend their film and TV content teams. Just that! So that’s the full topic of the day. I’m going to tackle the issue in the opposite direction of the way “stuff” flows: uphill. We’ll start at film, then move onto TV, and then onto the CEOs themselves, and the strategy questions that still remain. But we start with the numbers driving this. Let’s dive in. Subscribe Most Important Story of the Week - Netflix Upends Their Corporate Hierarchy I’ve got a lot of thoughts, but we’ll start with the most common response to yesterday’s article. Let’s Talk Stock Price More than one person, responding to what I published two days ago, pointed out that, well, actually, the thing driving Netflix’s actions is this: In short, stock price! Even if Netflix isn’t obsessed with their own share price—they probably are, but, for the record, my strategic advice to every CEO is to absolutely ignore stock prices, which will, ironically, probably help the stock price long-term—most everyone thinks they are. By the way, I prefer market capitalization to stock prices, because it’s a more apples-to-apples way to compare companies: But there’s an even better way to look at it, and it kinda casts some doubt on the entire push here: price-to-earnings. I have a long list of articles that I wish I had written, and chief among them is an article titled, “Am I Still a Netflix ‘Bear’?” meaning someone who thinks Netflix’s stock is overvalued. As of last summer, Netflix had solved their biggest problem—which for me (circa 2019) was the lack of free cash flow—but their stock was CRAZY overvalued. That’s this chart here: Why did Netflix’s stock price increase to a price-to-earnings ratio of 50 last summer? What financial metric changed so quickly? Nothing. Given that, historically, mature entertainment companies average 10 to 20, with 16 being the average, that increase made little sense. Netflix’s stock swoon these last eight or so months wasn’t irrational; the stock price rise last year was. So if you want a really hot Netflix take, here it is: Netflix’s stock price has been going down because the financial industry recovered its senses, not because of any strategic mistake. Yes, that would imply that cleaning house may have been a mistake. That’s why the charts yesterday are so important, because they show that Netflix did have a strategic problem (a lack of hits) and that’s what they moved to address. (One could also argue the industry drastically overrated Netflix’s growth prospects, but that’s a financial industry problem, not a Netflix strategy problem per se. Some growth estimates are just crazy. *cough* AI *cough*) Now, the last time Netflix’s stock price crashed—circa 2022—it gave them an opening. I’d argue Netflix insiders knew they needed to expand post-COVID-19 crisis, adding advertising, cracking down on password sharing, and dabbling in sports. But if they had done that when their stock price was high, it would give folks a reason to second guess their strategy. (Arguably, last year, when Netflix pursued the Warner Bros. merger, it gave the industry a chance to review their business.) Instead, after the 2022 fall, they had the opening to make strategic changes. We may see Netflix pivot again following this latest slide. For example, the “binge versus weekly” conversation is alive and well again. Same for expanding into theaters even more. And adding both linear channels and streaming bundles. And maybe more either social, user-generated, vertical, or creator content. But the first shift came with who is making the content calls. A Message from Our Sponsor Last winter Pulp Fiction was on Netflix. For those same 90 days, it was also free, with ads, on Pluto TV and the Roku Channel. That is not a glitch, and it is not rare. The title has run on 20 different US streaming services since 2019, across 80 separate windows, and for more than 600 of those days it sat on a paid subscription service and a free ad-supported one at the same time. Almost nobody can see this, because when a title leaves a service, the record that it was ever there tends to leave with it. Reelgood keeps that record, dated to the day rather than the month: 4MM+ movie, show and episode titles across 300+ services globally, with timestamped arrivals, departures and moves across SVOD, AVOD, TVOD and vMVPD. Licensing teams price against every prior window. Rights teams check what a licensee actually delivered, and when. Pick a title you think you know: data.reelgood.com/title-availability Film - Dan Lin Want to know why I don’t opine on individual film or TV executives, especially new hires? Dan Lin. As I always caution, it’s really, really, really tough to predict which executives will succeed in new roles and which won’t. The successful head of co-production/finance partner, Rideback, Lin was considered for the head of DC Studios job before taking the job as the head of Netflix. By all accounts at the time, this was a smart hire. (That’s my read of the news coverage anyways.) But now that Netflix has fired Dan Lin, we got a slew of news stories about how he was doing a terrible job. In sports media, Bryan Curtis, new Substack writer/podcaster from The Ringer, calls this the “now you tell us” story, when you only hear the bad news after a star athlete leaves a sports team. In this case, now they tell us that Dan Lin was bad with talent after he got kicked out the door. So was Dan Lin a flop? It’s actually tough to say. While film moves faster than TV, even two years isn’t really enough time to evaluate a person’s output. The new head hasn’t really taken control. As Emily Horgan noted, it takes much longer than two years to produce animated films, so yeah, it’s definitely too early to judge in that domain. As for live-action films, I just published an article by Brandon Katz called “Netflix’s Summer of Bummer”, but I’d point out Netflix had a bad summer two years ago too. Arguably, their best summer came from KPop Demon Hunters last year and Happy Gilmore 2, the latter of which I saw credited to Lin. Then, the stories came out that Dan Lin clashed with talent, both Ben Affleck and Greta Gerwig, classic “now they tell us” factoids to explain his firing. This may have been true, but also should have been expected given that he was given the mandate to bring budgets back in check, especially after Rebel Moon. So if he made folks upset, well, that’s what he was hired to do! But also, he was described as “well-liked” at his hiring! In that case, I’m a bit sympathetic to Lin, since he may have been undercut by senior leadership, as often happens. Basically, a CEO hires a subordinate to be their “bad cop” and keep budgets in check, but then when talent complains, the CEO ends up undercutting them. That’s how I think you end up with a Narnia movie as expensive as any of the other flops, along with a film executive the town no longer likes. As a result, I think that Netflix is now executing a classic “hire the opposite” move by hiring Peter Rice. This phrase comes from my experience following football and basketball coaching decisions, where teams generally hire the opposite of who they just had. If you have an offense-minded head coach, hire the defensive guy. Or in college football, if you have a strong recruiter, then you pivot to an “X’s and Os” type of guy. Or in pro basketball, if you have a very analytically minded coach, you hire the player-friendly guy. I see that here. After dropping Scott Stuber—arguably a talent-friendly executive with lax budget control—Netflix hired the business guy to keep costs in check. Now Netflix is pivoting back to Peter Rice and presumably a more talent-friendly regime. (Disney, by the way, has done this twice: hiring business guys to succeed talent-friendly Bob Iger. It didn’t work out last time.) When it comes to Peter Rice…we’ll see! Maybe he works out, but maybe he doesn’t. I’d actually say the biggest problem is that Netflix still hasn’t solved its “IP Problem”, in that they don’t own much IP, so they just have a lower hit rate. The new executive won’t solve that. (Though buying Lionsgate would help.) Share “Content” - Bela Bajaria I almost published yesterday’s article after this column, but ended up flipping the order, because it told the story so well. So if you want the data for why Netflix is looking at TV to fix their problems, it’s in that article, this graph in particular: I know I just wrote that it’s often hard to judge executives, but Bajaria ran TV for six years and film for three and a half more. That’s more than enough to judge hit rates, and Netflix needs more hits. That’s the story. Since 2023, Netflix hasn’t had as many hit shows as it used to, and many of its previous power house TV shows have ended their runs (Stranger Things most of all). Also, many shows from 2020 to 2022 probably pre-dated Bajaria’s tenure. (That said, one thing may have been outside of Bajaria’s control, which I explain below.) Let’s lump some content strategy thoughts about Netflix and TV into one place: We’re just getting started with this issue, but the rest is for paid subscribers of the Entertainment Strategy Guy, so if you’d like to find out… Why I partially blame Squid Game for Netflix’s latest troubles… What is “the football trap”... Why it might not be the TV shows or films’ fault at all… What change I don’t think Netflix will make... How Bela Bajaria evolved Netflix’s TV strategy in smart ways… Whose departure likely submarined Bajaria’s final few years… One sneaky explanation for Netflix’s content struggles... And a whole lot more... ...please subscribe! We can only keep doing this great work with your support.
Political attack ads are ugly. We don’t have to be
Political division is testing our character. It is time to trade the anger for kindness and respect.
California election officials frustrated, rattled by DOJ demand to sequester 'noncitizen' ballots
The administration has insisted that immigrants voting is a major problem nationwide, when in fact it is quite rare, as even its own investigations have shown.
Browns Week 7 inactives: Who's in, who's out?
The Browns are the healthiest they have been in some time as they take on the Titans in Week 7.
Tiger Woods Gets Double Good News as Vanessa Trump Shares Health Update
Tiger Woods remains a presence in golf through his playing career, business ventures, and course-design work. His TGR Design firm has worked on several projects, while a proposed development in Northern Ireland has attracted attention from the golf industry.Away from golf, Woods has also drawn public interest through his relationship with Vanessa Trump. The couple […] The post Tiger Woods Gets Double Good News as Vanessa Trump Shares Health Update appeared first on HEAVY.
NMSU research centers celebrate fall with outreach events
NMSU agricultural science centers hosted fall learning events featuring farm demonstrations, pumpkin patches and hands-on activities for elementary students.
Face the Facts: New health insurance helps early childhood educators
Child care is expensive, and keeping qualified workers on the job is part of the challenge. Now, Connecticut is offering a new health insurance subsidy to help early childhood educators lower their monthly premiums. Rep. Kate Farrar (D-West Hartford) explains how it works and why it could make a difference for families. Mike Hydeck: For years, Connecticut has had among…
FEMA deadline approaching for NW Indiana residents, businesses impacted by Aug. 11 storms
Detroit Lions Announce Decision on Brian Branch, Cade Mays
The Detroit Lions officially activated Brian Branch and Cade Mays ahead of Sunday's Week 7 showdown against the Green Bay Packers.
Wrexham’s Summer Striker Decision Faces Fresh Scrutiny After Blackburn Defeat
Wrexham’s decision to back their current centre-forwards has become a renewed talking point after Saturday’s 2–0 defeat at Blackburn Rovers exposed the gap between attacking activity and a meaningful goal threat.
Best AI Tools for Small Business Marketing (2026): CapCut Featured for Creating Professional Video and Visual Content by Expert Consumers
Expert Consumers has recognized CapCut in its 2026 coverage of the best AI tools for small business marketing, highlighting the platform's collection of AI-powered features for creating and editing video, images, audio, and other visual content. The recognition reflects growing interest in tools that support practical marketing activities, including campaign development, promotional content production, and adapting creative assets for different digital channels.
Investment driving growth at NWS Crane
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Rumored Lucia Actress Goes Viral After Dodging Swarm of GTA 6 Comments During Livestream
Manni L. Perez, the actress long rumored to be playing Lucia in GTA 6, has gone viral after dodging a swarm of comments from Grand Theft Auto fans during a recent livestream.
Ukraine making signal repeater drones to help other drones fly further
Ukraine's drone pilots can only fly them so far before signal is lost. But other drones act as hovering signal relays to extend their range.
Hints About Why Sabres Missed Connor Hellebuyck
The fact that the Buffalo Sabres missed out on Connor Hellebuyck could linger painfully for a while if the goalie play in Western New York doesn’t improve in a hurry. It’ll hurt all the more because the reports over the summer indicated that for at least a time, the Sabres were the frontrunners to pull […] The post Hints About Why Sabres Missed Connor Hellebuyck appeared first on HEAVY.
Steelers Give Aaron Rodgers Another Familiar Option
For the third week in a row, the Pittsburgh Steelers have elevated Brandon Smith from the practice squad. Smith, who […]
Liverpool and Man United contacted about transfer of wonderkid
Liverpool have a fair few positions among their ranks that still need to be upgraded. The Anfield outfit have fallen behind their title rivals quite dramatically recently with most of their players fa...
Pair of CBs Lead Steelers Inactives vs. Saints
Terell Smith will have to wait to make his Pittsburgh Steelers debut for at least another week. The fourth-year cornerback, […]
Vikings Linked to Potential Sleeper Running Back Trade
The Minnesota Vikings are one of the only unbeaten teams left in the NFL entering Week 7 action. Coming off of their bye week, Kevin O’Connell’s team will face off against the Indianapolis Colts at home on Sunday afternoon. So far this season, the Vikings have looked the part of a legitimate contender in the […] The post Vikings Linked to Potential Sleeper Running Back Trade appeared first on Gridiron Heroics.
A New Level of Threat and Fear Risks Pushing the U.S. and Iran Back to Full War
With new intelligence and the possibility of all sides seeking pretexts for action, the war in Iran is entering a dangerous phase ahead of elections in the United States and Israel.
Luke Kuechly Calls Netflix NFL Role a Work ‘In Progress’
Kuechly is also calling some regional NFL action for CBS.
This mysterious mushroom makes people see hundreds of tiny humans
For nearly a century, people in distant parts of the world have reported a bizarre experience after eating certain wild mushrooms: seeing dozens or even hundreds of tiny, colorful humans moving through the real world. Now, scientists have identified a mushroom species, Lanmaoa asiatica, responsible for these extraordinary hallucinations in China and the Philippines.
Scientists Find Chronic Back Pain Activates a Brain Network Linked to Personal Identity
A new UC San Diego brain imaging study involving 114 adults suggests that chronic back pain flare-ups affect brain networks involved in self-reflection and personal memories. The findings may help exp...
Jayson Tatum Reacts to Encouraging Celtics Development Against Knicks
The Boston Celtics beat the New York Knicks 107-103 on Friday night at TD Garden. Jayson Tatum scored 36 points and closed the game with a run that sealed the win. The stat line told the obvious story.But after the game, the moment Tatum wanted to talk about was not one of his own. It […] The post Jayson Tatum Reacts to Encouraging Celtics Development Against Knicks appeared first on HEAVY.
Jacksonville Jaguars’ Major Offensive Issue After 4-2 Start Revealed
The Jacksonville Jaguars’ 4-2 start has been overshadowed by a recurring offensive problem, as penalties continue to erase scoring opportunities and disrupt drives. Costly infractions have prevented the team from maximizing its production, raising concerns about discipline as Jacksonville looks to remain competitive in the AFC. The Jaguars have already had three touchdowns wiped off […] The post Jacksonville Jaguars’ Major Offensive Issue After 4-2 Start Revealed appeared first on Gridiron Heroi
YouTube Gold: Highlights From Louisville’s Trip To Kansas
Kansas lost Wednesday, but the Jayhawks are not exactly pushovers
Photographer and medical professionals connect science and art during panel discussion
In 2020, the world was put on hold because COVID-19 began claiming the lives of people all over the globe. When a vaccination for the illness was finally made public in 2021, being vaccinated became highly politicized. Instead of focusing on the emotional reactions that people had toward the vaccine, artist Linda Alterwitz was more...
Steelers Get Good News on Rico Dowdle
Pittsburgh Steelers running back Rico Dowdle (knee) is active for Sunday’s game against the New Orleans Saints in Paris after […]
#ESMO26: Merck and Moderna's cancer vaccine data were 'a triumph of science.' And now, the work begins
Merck and Moderna’s intismeran cut melanoma recurrence risk 42% at ESMO; experts weigh other tumors, manufacturing and boosters.
Colts make roster moves ahead of road matchup vs. Minnesota
The Colts are elevating a familiar face at linebacker to their active roster ahead of Sunday’s road game.
Real Madrid boss Jose Mourinho sends DEFIANT Lamine Yamal message ahead of El Clasico
Real Madrid manager Jose Mourinho insists his side will not alter their tactical approach to deal with Barcelona sensation Lamine Yamal in Sunday's massive Liga fixture. The Portuguese coach dismissed his team's recent thrashings of Sevilla and RB Leipzig, declaring that previous form means nothing during El Clasico.
Nashville SC aim beyond Supporters’ Shield: “Ready for more"
By Ben WrightMONTRÉAL - Even with the 2026 MLS Supporters' Shield freshly in tow, Nashville SC aren't satisfied. Far from it.In fact, Saturday's 2-0 win at CF Montréal that clinched the second troph...
Oprah on the Health Metric We Should All Be Tracking
“These facts are a wakeup call for all of us to get serious about our heart health.”
Global Leading Robot Dog Dinosaur Manufacturer Hidinosaurs: Redefining Smart Entertainment at CAAPA
The location-based entertainment industry is entering a new era driven by Smart Entertainment, where interactive technology and immersive storytelling define
LIVE! Watch UFC 333 Post-Fight Presser
With UFC 333 officially a wrap after an entertaining card earlier today (Sat., Oct. 24, 2026) LIVE on Paramount+ from inside Etihad Arena in Abu Dhabi, United Arab Emirates, fight fans can now check out the post-fight press conference video above for all the best reaction and official bonus winners. On a day that featured […]
Mystery Ohio news site boosting Ramaswamy's Amy Acton ad tied to California GOP non-profit
As Ohio Republican gubernatorial candidate Vivek Ramaswamy came under fire for releasing an attack ad featuring his Democratic competitor Amy Acton's estranged mother, a mysterious news site was runni...
Denver Film declares John Cho an outlaw
Dispatch from the Denver Film Festival: Evolving comic actor John Cho accepts award and talks about his sinister turn as a cult leader ... Local filmmakers make the case for stronger Colorado film incentives. That and more.
Google DeepMind exec shares skills that can make graduates stand out
Extra-curricular activities on a CV show if someone has a preset for "lifelong learning," said Google DeepMind exec, Lila Ibrahim.
5 Cool Facts About The Ecto-1 Every Ghostbusters Fan Should Know
From its rarity to fun behind-the-scenes details, these are the most interesting facts about the Ecto-1 that every die-hard "Ghostbusters" fan needs to know.
Obama compares Trump's White House renovations to 'Saddam Hussein opening a Cheesecake Factory' at Ohio rally
Barack Obama compared Trump's White House renovations to a Cheesecake Factory run by Saddam Hussein at a Cleveland rally for Ohio Democrats.
Burnham open to 'honest discussion' on EU free movement
The PM said he wants a "factual" and "evidence-based debate" about returning to free movement between Britain and Europe.
Multiple Browns injury updates surface ahead of Week 7 matchup
The Cleveland Browns made several roster moves Saturday ahead of their Week 7 matchup against the Tennessee Titans , activating running back Dylan Sampson from injured reserve while placing offensive guard Teven Jenkins on injured reserve. ESPN’s Adam Schefter reported Saturday via X, formerly known as Twitter, that Cleveland also elevated […] The post Multiple Browns injury updates surface ahead of Week 7 matchup appeared first on ClutchPoints.
Updated SEC football conference standings following Week 8 upsets
The SEC's Week 8 slate produced a number of notable results. Here is how those results impacted the conference standings entering Week 9.
Los Angeles health authorities report 2nd second rabies-positive raccoon
In a follow-up on the report a rabies-positive raccoon found in Los Angeles County, the first in more than 5 decades, the LA County Department of Public Health is investigating a second rabies-positive raccoon found in the Westlake Village area of Los Angeles County. Public Health has confirmed that the first raccoon was positive for a variant of rabies typically found in bats. Strain testing for the second raccoon is currently pending. The second rabid raccoon was found in a backyard in the vicinity of where the first raccoon was reported and appeared sick and aggressive. No residents or pets were exposed to the raccoon. Two people at a worksite may have been exposed to the raccoon and are receiving recommended follow-up for rabies post-exposure prophylaxis. The World’s Deadliest Viruses Prior to these detections, the last confirmed rabid raccoon in Los Angeles County was detected in 1973, when the skunk variant (strain) of rabies was still present in the County. That strain has not been detected in Los Angeles County since 1979. In 2014, a skunk infected with the bat variant of rabies was detected in Long Beach. “The detection of rabies in another raccoon is an important reminder to never touch, handle, or feed any wild animals, even when they appear healthy,” said Muntu Davis, MD, MPH, Los Angeles County Health Officer. “Always keep a safe distance from wildlife and contact your local animal control if you encounter an animal that appears to be sick, injured, or behaving unusually. It is also critical to ensure your pets are up to date on rabies vaccination so they are protected before any potential exposure. Keeping your pets vaccinated is one of the most important steps you can take to protect your entire family.” Outbreak News Today is a reader-supported publication. To receive new posts and support my work, consider becoming a free or paid subscriber. Subscribe
READERS' CHOICE | Impact Realty Group makes its mark with Best Small Business win
A locally owned and operated real estate brokerage has been named Best Small Business in the 2026 Texarkana Gazette Readers' Choice Awards.
Leland Fall Festival brings trick-or-treating, live entertainment to Founders Park
The Town of Leland is inviting families to celebrate the fall season with a free festival featuring trick-or-treating, live entertainment and activities for all ages.
ESMO: Roche touts ‘convincing’ phase 3 KRAS data after win over rivals
Roche has shed more light on its investigational KRAS G12C inhibitor's phase 3 victory over Amgen’s Lumakras and Bristol Myers Squibb’s Krazati. The open-label Krascendo 1 trial enrolled 338 people with previously treated KRAS G12C-mutated non-small cell lung cancer (NSCLC). Patients who had already received a KRAS G12C inhibitor or pan-KRAS/RAS inhibitor were excluded from the trial. Participants received either divarasib once daily, Lumakras once daily or Krazati twice daily. Roche announced back in July that divarasib had demonstrated statistically significant improvements in progression-free survival (PFS) and overall survival (OS), meeting the trial’s primary and key secondary endpoints. But the Swiss pharma had been holding back the detailed data until now. At the European Society for Medical Oncology (ESMO) Congress in Madrid, Roche revealed that median OS for the 167 patients who received divarasib was 17.7 months, compared to 12 months for the 171 patients who received Lumakras or Krazati. The benefit was similarly clear when it came to median PFS, which stood at 9.8 months versus 5.7 months, respectively. A total of 44% of patients receiving divarasib were alive without disease progression at one year, compared to 24% of the control group, according to Roche’s presentation. It was a similar story for the objective response rate, which came in at 58% for divarasib versus 32% for the control group, while median duration of response was 11.9 months versus 6.9 months. Stefan Frings, M.D., Ph.D., deputy chief medical officer at Roche Pharma, told Fierce that the data made for a “very comprehensive, strong package, which should be convincing to health authorities.” “It’s an important advance for patients with lung cancer,” Frings said in an interview at a Madrid hotel during the conference. “It's a second-line setting, and patients who receive divarasib benefit compared to the current first-generation KRAS G12C inhibitors by having far longer overall survival,” he continued. “They live longer. They have better progression-free survival, better response rates, and with a safety profile which is—if [anything]—even better,” he said. According to Roche, 4.8% of patients receiving divarasib discontinued treatment due to treatment-related adverse events, compared to 11.7% in the control group. Serious treatment-related adverse events were also less common with divarasib, at 7.8% versus 15.2%. Roche’s confidence in divarasib had been building even before this phase 3 success. The candidate had already shown better potency and selectivity than the incumbent KRAS G12C inhibitors Krazati and Lumakras in preclinical tests. After cross-trial comparisons suggested that the edge translated into better clinical outcomes, Roche axed a study comparing divarasib to the chemotherapy docetaxel and went toe-to-toe with Lumakras and Krazati. “We designed the drug on purpose with higher potency and better selectivity,” Frings explained. “So, based on preclinical models, we clearly knew it would be superior to the first generation.” “It’s honestly not so frequent that pharma companies go head-to-head,” he added. “But if you want to make a point, if you want to convince payers, prescribers and patients … then a head-to-head win is rather rewarding.” While Amgen and BMS reached the regulatory finish line first for KRAS G12C-mutated, locally advanced or metastatic NSCLC in 2021 and 2022, respectively, they have struggled to capitalize on their head start. Krazati brought in $55 million for BMS in the second quarter, while Lumakras delivered $111 million to Amgen. For its part, Roche is aiming for peak divarasib sales of 1 billion to 2 billion Swiss francs ($1.2 billion to $2.5 billion), according to Frings. The Big Pharma is currently recruiting patients into a phase 3 trial comparing divarasib plus Keytruda against Keytruda plus chemotherapy in previously untreated advanced or metastatic nonsquamous KRAS G12C-mutated NSCLC. Roche has previously suggested that sales in metastatic disease would account for most of the forecast. Frings was tight-lipped on the exact timeline for a regulatory filing but said the Swiss pharma is “certainly keen to get this to as many patients as possible around the world.” Roche has more RAS drugs coming up behind divarasib. The pharma has already launched phase 1 trials of a pan-RAS inhibitor called RG6505 and a KRAS G12D inhibitor dubbed RG6620 in solid tumors. Roche’s partner Chugai Pharmaceutical is also testing a pan-KRAS inhibitor called AUBE00. Roche has made a “deliberate effort” to test a range of RAS drugs, Frings said. “If you have many rare mutations and you are scrambling to find sufficient patients, a pan-RAS inhibitor makes a lot of sense,” he explained.
Common Liver Disease May Actually Have 5 Distinct Types With Different Health Risks
Each may need their own treatments.
Maliek Collins agrees to terms on contract extension
Maliek Collins to remain in Cleveland for two additional years
Preview
The Men's First Team are back in Serie A action, this time heading south to face Lecce in Puglia.The Serie A Matchday 8 clash is set to take place at the Stadio Via del Mare at 18:00 CET on Sunday, Oc...
New York Giants activate Paulson Adebo; elevate Jalin Hyatt
The New York Giants have made a series of roster moves, including the activation of CB Paulson Adebo and the elevation of WR Jalin Hyatt.
NC business co-owner kills man ‘acting irrationally’ outside Zumba class, police say
A man “acting irrationally” toward patrons of a Zumba fitness class was fatally shot when he turned his attention to an armed business co-owner at the scene, according to investigators in western North Carolina. The confrontation occ…
Browns sign Maliek Collins to $30 million extension
The Cleveland Browns have secured one of their standout defensive players for the future before their next game against the Tennessee Titans . Cleveland defensive tackle Maliek Collins has agreed to a two-year contract extension worth $30 million. According to NFL insider Ian Rapoport, Collins’ agent, Drew Rosenhaus, confirmed the agreement to him […] The post Browns sign Maliek Collins to $30 million extension appeared first on ClutchPoints.
Common Liver Disease May Actually Have 5 Distinct Types With Different Health Risks
Each may need their own treatments.
Scientists Trapped an Antimatter Particle for Months to Study Its Secrets
These elusive and reactive particles have been challenging to hold on to and even more challenging to study, but a new method paves the way for tests on the differences between matter and antimatter.
Obama rips into Ramaswamy over attack ad: ‘There’s no line he won’t cross’
The Ramaswamy campaign cut in half the length of the ad featuring Amy Acton’s estranged mother after the spot sparked an uproar.
Jon Gosselin’s ex shares emotional reaction to Collin’s book: ‘I will always be your mom’
Colleen Conrad dated the “Jon and Kate Plus 8” star from 2014 to 2021.
Small gyms increase health and connection in rural communities
Within the Adirondacks, outdoor recreation keeps people active. But small gyms popping up encourage indoor activity.