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Chuck Lorre claims Les Moonves made ‘no f---ing way’ gesture at Jon Cryer’s ‘Two and a Half Men’ audition
Chuck Lorre recalls casting ‘Two and a Half Men’ in his new memoir, ‘Sitcom,’ and being told by the network, ‘We don’t want to hear the words ‘Jon Cryer.’’
Guardians just one part of huge weekend for Ohio sports
Postponements due to inclement weather usually don’t include a positive outcome. But Friday night’s Game 4 postponement, pushing the ALCS back a day, made this weekend in the rock and roll capital of the world that much more jam-packed, with the Guardians' push for their seventh World Series appearance at
UCLA’s fairy tale was supposed to end. Then Ty Dieffenbach happened
Ty Dieffenbach stepped in for Nico Iamaleava and came up clutch for UCLA to keep the undefeated start rolling for the Bruins.
Cleveland Browns Path To The Playoffs
Welcome to my weekly Cleveland Browns rooting guide looking at the best outcomes for the Cleveland Browns. With many of the top quarterbacks in the league not being selected in the first three picks, the Browns winning games isn't a bad thing, it shows the roster is loaded and able to continue improving with another offseason.What we will cover weekly in this article:- Current AFC Playoff Games-...
Louisiana renews deals with 4 Medicaid providers; lawmakers want better health outcomes
Louisiana lawmakers renewed state contracts Thursday with four private managed care organizations that provide Medicaid coverage, calling on state health officials to ensure the money results in better health outcomes.
World time to drop the leap second from May 2027
Global timekeepers have voted to end the practice of adding extra seconds to UTC, citing risks to computer systems and the prospect of the first-ever negative leap second.
IU Kelley School of Business Expert Weights in on Prediction Markets and Midterm Elections
As prediction markets play a growing role in election forecasting and increasingly compete with traditional polling, Russell Rhoads, clinical associate professor of finance at the Indiana University Kelley School of Business Indianapolis, is available to provide expert analysis and commentary. Rhoads can help audiences understand how prediction markets work, what market odds actually signal about election outcomes, and why investors, analysts, and political observers are payin
Lisandro Martinez is ‘The Butcher’ who meditates, loves crying and dreams of becoming a sporting director
The centre-back criticised the Man United hierarchy live on TV and has since apologised. He is outspoken, emotional and hard to categorise
AI study of 101,000 patients links brown fat to heart and mental health
In a retrospective analysis of PET-CT records from 101,243 patients, researchers found that detectable brown fat was associated with lower prevalence of cardiometabolic and psychiatric conditions, while greater activity, particularly in the axillary region, was linked to more favourable metabolic outcomes. Medication screening identified losartan, which increased brown fat thermogenic activity in laboratory experiments and energy expenditure in mice, although its effects on human brown fat remain unproven.
10/15/26: White Paper - Small Business Trends in Chattanooga - Center for Regional Economic Research
A new white paper released by the CRER looks at trends in small business in Chattanooga since 1978. Small firms are much more numerous in Chattanooga than are medium and large firms, although their number has grown much more slowly. Between 1978 and 2023, the number of small firms grew by 27 percent whereas the… Continue Reading
How BPC is Building Bipartisan Momentum on Youth Mental Health
America’s youth mental health crisis didn’t begin with COVID-19, but the pandemic dramatically accelerated it. More than 40% of teenagers reported persistent feelings of sadness or hopelessness. Youth suicide attempts, self-injury, and drug overdoses climbed to alarming levels. Meanwhile, the behavioral health system meant to catch these young people remains chronically understaffed and poorly designed … Continued
Women’s Health Conference highlights 50th anniversary of Nurses’ Health Study | Harvard T.H. Chan School of Public Health
Speakers highlighted solutions for improving women's health outcomes, and marked the 50th anniversary of the landmark Nurses' Health Study.
Federal maternal, infant health data collection system remains weak, puts health outcomes in jeopardy | Harvard T.H. Chan School of Public Health
Medicaid funding cuts are jeopardizing the health of U.S. mothers and infants—and with a weak federal database to monitor maternal health outcomes, the consequences may be invisible, according to Harvard Chan School experts.
California students post gains in math, science and English in 2025-26
SACRAMENTO, Calif. — California students made gains across key academic and success measures during the 2025-26 school year, with test scores rising in English, math and science while the statewide graduation rate reached a record high of 87.9 percent. For the first time, the state released assessment results and California School Dashboard data together to give families and educators a more complete picture of student performance.English language arts scores increased 0.5 percentage points to 49.3 percent of students scoring proficient or advanced, while math scores rose 1.1 percentage points to 38.4 percent. Science showed the strongest improvement, jumping 3.3 percentage points to 36 percent of students scoring proficient or advanced.The statewide chronic absenteeism rate dropped 1.1 percentage points to 18.3 percent. The suspension rate declined to 2.8 percent, marking the third consecutive year of improvement."At a time when California continues to focus on accelerating learning and closing opportunity gaps, these results provide important evidence that our sustained investments are making a difference," Gov. Gavin Newsom said. "The continued progress we are seeing is a testament to the hard work of students, families and educators across the state—and we will continue working to build on these gains."The percentage of students prepared for college and career increased to 55.2 percent, up 2 percentage points from the previous year. More than 54 percent of graduates completed coursework required for admission to University of California and California State University systems, an increase of 0.9 percentage points."California has made important strides in expanding student supports and opportunities, but the pace of academic improvement reminds us that our work is far from finished," State Superintendent of Public Instruction Tony Thurmond said.Eighth grade students posted the strongest score trends in both English language arts and math. Science performance improved across all tested grades, with the strongest gains at the high school level.African American students demonstrated larger-than-average improvements across English, math and science. Hispanic or Latino students showed larger-than-average improvements in English and math, with positive math score trends across all grades.Students who were socioeconomically disadvantaged made gains across all 3 subjects, including larger-than-average improvements in English and math. Students who were homeless continued to demonstrate gains across grades, with particularly strong improvements in math."We are encouraged to see students making gains across all 3 major assessments and are especially encouraged by the progress of African American students, Hispanic or Latino students, socioeconomically disadvantaged students and homeless youth," said Linda Darling-Hammond, president of the California State Board of Education.The progress comes as California's public school system undergoes significant demographic change. Statewide school enrollment declined to approximately 5.73 million students in 2025-26, nearly 500-thousand fewer students over the past decade.The number of students with disabilities increased approximately 25 percent over the same period, from about 680-thousand to more than 850-thousand students. Graduation rates increased across nearly all student groups, including notable increases for American Indian or Alaskan Native students at 4.3 percentage points and students with disabilities at 3.7 percentage points.In Downey Unified School District, the rate of students demonstrating proficient or advanced grade-level knowledge increased by 2.1 percentage points in English, 2.8 percentage points in math and 4.7 percentage points in science. The district aligned graduation requirements with college admission expectations and invested in inclusive special education practices, expanded career technical education and expanded learning opportunities."The gains Downey Unified is seeing in student assessment results and on the Dashboard are the result of years of focused, consistent work across the district," Superintendent Roger Brossmer said.In Exeter Unified School District, proficiency rates increased by 4.6 percentage points in English, 2.3 percentage points in math and 3.6 percentage points in science. The district placed a strong focus on phonics and the science of reading, particularly in kindergarten through second grade."The gains Exeter Unified is seeing in student assessment results and on the Dashboard are the result of having great people who are focused on the right work, and great students who want to do well," Superintendent Melanie Dorough said.Union Elementary School District saw proficiency rates increase by 1.5 percentage points in English, 2 percentage points in math and 4 percentage points in science. Teachers regularly analyze state and local assessment data to guide instruction, supported by strong core instruction and early literacy strategies."Union Elementary School District's achievement gains reflect a focused, data-driven approach to meeting the needs of every student while fostering a strong sense of belonging, safety and connection," Superintendent Carrie Andrews said.The California Department of Education is examining local results to better understand strategies and conditions associated with stronger student outcomes. The state has made significant investments in recent years, including literacy and math coaching, tutoring, expanded learning opportunities, community schools and universal transitional kindergarten.
Controversial Total War Remaster Being Delisted From Steam After AI Allegations
'Total War: Shogun 2 - Complete Edition' is being delisted from digital storefronts after fan outcry.
As Florida Confronts Hundreds of Local Dengue Cases, Tampa Health Organizations Respond
Florida health officials have reported almost 300 locally acquired dengue cases as of Oct. 3 in what appears to be the largest outbreak of the mosquito-borne disease in the continental United State…
Here’s how David Crowley and Tom Tiffany differ on healthcare
Wisconsin spends more on healthcare than neighboring states without notably better outcomes. How will the next governor manage the health of Wisconsinites?
Reclaiming the Politics of the Possible
Washington is stuck in a cycle of performative conflict. The incentives seem to reward outrage, not outcomes that last; purity tests, not problem‑solving. So it’s no surprise that after three shutdowns in less than a year, public approval of Congress collapsed to just 10 percent this spring. (Gallup...
Studies examine the connection between primary care provider resources and health outcomes for type 2 diabetes patients
Within the medical ecosystem, health guidelines aim for timely diagnosis and regular follow-up of chronic illnesses, such as type 2 diabetes, to ensure that no patient gets left behind. However, two studies ...
Low-Income Countries’ Push For Climate Money For Health Meets German Pushback Ahead Of COP31
BERLIN – Germany's top climate civil servant pushed back on Monday against a call from the world's poorest countries for more climate finance for health. The money fight of COP31 opens officially in Antalya, Türkiye, next month. In the halls of the World Health Summit in Berlin, it's already started.
You Bought AI to Save Time. So Why Are You Busier Than Ever?
AI improves productivity only when leaders fix the underlying business system, delegate outcomes effectively, and stop managing every task.
Heart Surgery Programs at Two MedStar Health Hospitals Earn Top Quality Ratings
WASHINGTON -- Two MedStar Health hospitals have earned the highest quality designation, a three-star rating, from the Society of Thoracic Surgeons (STS), placing their cardiac surgery programs among the nation’s best for patient outcomes and surgical care.
UNCP Computer Science Program earns ABET accreditation
Photo by UNCPUNC Pembroke’s Bachelor of Science in Computer Science program has earned initial accreditation from ABET’s Computing Accreditation Commission, providing independent recognition of the quality and rigor of the program as it prepares students for careers and advanced study in computing.The accreditation, which extends through Sept. 30, 2032, comes as UNCP continues to expand its computing programs amid rapid growth in artificial intelligence, cybersecurity, data science and other emerging technologies.ABET accreditation is a voluntary, peer-reviewed process that evaluates academic programs against established standards for quality. The review examines curriculum, student outcomes, faculty qualifications, assessment practices, student support and continuous improvement.“Earning initial ABET accreditation is a significant milestone for our Computer Science program because it provides external recognition of the quality of our program and validates our commitment to continuous improvement,” said Dr. Haitao Zhao, assistant professor in the Department of Mathematics and Computer Science, in a press release. “For our department, this achievement reflects the hard work and dedication of our faculty and staff and gives our students greater confidence in the quality of their education and preparation for careers and graduate study.”For prospective students, the accreditation provides independent assurance that UNCP’s program meets standards established for computing education and is preparing graduates to enter technical fields in the global workforce.Earning the accreditation required faculty and staff to conduct a comprehensive review of the program, including its curriculum, educational objectives, student learning outcomes and assessment processes. The review included a detailed self-study, documentation and an on-site evaluation.The accreditation arrives as UNCP looks toward the next phase of growth in computing. The department plans to continue strengthening its computer science curriculum while expanding hands-on learning and research opportunities for students. It also plans to pursue ABET accreditation for its information technology and cybersecurity programs.Future plans include developing new opportunities in artificial intelligence and graduate education, including an AI track and a Master of Science in Computer Science with a focus on AI and cybersecurity.
PROFILE: Ben Sio
New President of CenterState CEO Brings Nearly Two Decades of Experience to Drive CNY Growth By Stefan Yablonski Ben Sio serves as president of the CenterState Corporation for Economic Opportunity — or CenterState CEO. The independent Syracuse-based nonprofit is committed to creating inclusive, equitable and sustainable economic growth in Central New York. “I started in this position in March, so it has been six months. I’m in my 19th year with CenterState,” he said in August. As president, he is responsible for overseeing the organization’s administration and governance, while leading and executing its vision to be an effective advocate, exceptional employer and a force for positive outcomes for the community. He previously served as chief of staff and senior vice president of strategy, policy and planning, overseeing the organization’s long-term strategic planning, consulting, corporate governance, fundraising and development, land-use planning and government relations. In his years with the organization, Sio has led or supported many high-profile strategic initiatives including the creation of the CNY Rising Plan, the launch of the NUAIR Alliance and the region’s UAS strategy, the creation of the Micron-enabled Community Priorities Document and the recently awarded NY Smart I Corridor Tech Hub. “When we decided to split Rob’s [Simpson] role into two positions, he has the CEO title and I got the president title. Rob remains focused on forward looking vision strategy for the organization and I’m more focused on the day-to-day operations,” he explained. “I’m also responsible for building consensus around strategic needs and priorities and managing the change necessary to drive execution. It’s an eventful job. “The experiment that we call CenterState is always evolving and shifting and addressing where we see market demand and market failure. “If we see something in our economy that isn’t going the way we think it should go, then whether it is housing development or workforce development or something else, we are always figuring out how to step into these situations and address those challenges.” “We are the largest ever in terms of staff that we have ever been. We are no longer the 20-person organization we were when we started out many, many years ago,” he said. “There are more day-to-day things to take care of. But also there is just so much happening in the community right now that is pulling CenterState and our expertise in so many directions. I tell people if we were bored and not busy, then I’d be really concerned about what we are doing. But we are not bored. We’ve certainly got our hands full — and that is a good thing.” CenterState has now approximately 63 employees on its staff, according to recent nonprofit database records. It’s involved in myriad programs, ranging from Genius NY, a business accelerator competition for uncrewed systems, IoT and robotics startups, to CenterState Up Start, a collaborative business development program that connects local, service-based businesses and aspiring entrepreneurs to the tools and networks that help them thrive. CNY Guy Through and Through A Central New York guy through and through, Sio was born and raised in Skaneateles. “My mom was a teacher, an art teacher. My father worked for many, many years with National Grid. He was there through the transition from Niagara Mohawk to National Grid,” he said. “Neither of my parents were touched by cutbacks and job loss. But I grew up going through that transition and being concerned that there were rounds of layoffs. My childhood connection to the economy here in Central New York … years ago it was on the decline. There were people that lived here that were concerned about losing their job. They were thinking they lived in a place that didn’t show much promise.” That narrative translated to his generation, he added. “The kids that grew up in the ‘90s in Central New York were very much told, directly or indirectly, by their parents, that they had to go somewhere else to find economic opportunity. That is what I grew up thinking,” he said. “I only went a few miles down Route 20 for college — in Geneva, New York; I graduated from Hobart and William Smith College with a bachelor’s degree in public policy and political science. “I got real interested in regional economies; because what makes regional economy is what makes the economy successful. And when I graduated, I had an opportunity to move to Washington, DC and work down there at a nonprofit doing this work.” However, he decided to stay in Central New York. “I got hired two weeks after I graduated. I got hired by the Greater Syracuse Chamber of Commerce. At the time it was one of two entities doing economic development in Central New York — [the Greater Syracuse Chamber of Commerce and the Metropolitan Development Association] — and it eventually became CenterState CEO,” he said, referring to 2010 merger between the two organizations. During his time at CenterState, Sio has also split time at the Brookings Institution in Washington, D.C., where he supported communities developing export and foreign direct investment (FDI), a long-term cross-border investment where an individual or company from one country buys a lasting stake or control in a business located in another country. The program — known as Global Cities Initiative — was designed to help leaders in major U.S. and international metropolitan areas reorient their local economies toward global markets. “Early on in my tenure at CenterState, we had done a lot of work with the Brookings Institution, just regional planning stuff. We worked with them on developing a regional export plan, to export more products out of Central New York and a larger business plan for the region. They hired me on to help replicate those plans in different parts of the country,”Sio explained. “So, I worked there for three or four years. I worked for CenterState, but I was technically loaned to Brookings for a period of time to help them do this work elsewhere.” Family ties “My wife is Carly. We have been married 14 years. We have two kids, a 3-year-old and a 7-year-old. “With a 3-year-old and a 7-year-old, fun is a relative term these days. We do a lot of hiking. The kids this summer got very interested in waterfalls. We’ve hit every waterfall we could in a short hike — we’ve done Skaneateles and some others.” “I do woodworking and wood turning — it’s a branch of woodworking; you use a wood lathe. My big thing there is making wood bowls. I do that in most of my free time, which is not much,” he quipped. “I like to get into my woodshop and make a bowl and decompress and turn off the rest of the world for a little bit. I usually do it late at night when the house is quiet. It is definitely my escape from the day to day. I make a lot of bowls; all different sizes, all different species of wood. It’s a fun thing to do for me.” He gives away many of his creations. “They are mostly gifts — I don’t really sell them. I really don’t have time to go set up a booth at a fair or craft show. I usually give them away. I donate them to different things. If you are in my periphery, you’ve likely received a salad bowl from me as a gift. I just need to find something to do with all the stuff that I create,” he said. Lifelines Name: Benjamin Sio Position: President, CenterState CEO Birth Date: Not provided Birth place: Syracuse Residence: Westvale Education: Hobart and William Smith Colleges in the Finger Lakes Affiliations: Member of the boards of Skaneateles Festival, Greccio Foundation, Interfaith Works, CNY Community Foundation Personal/family: Married with two kids Hobbies: Woodworking and woodturning
UTC doctoral student Zach Lloyd finds his path in cybersecurity
University of Tennessee at Chattanooga doctoral student Zach Lloyd spent the summer at the Naval Information Warfare Center (NIWC) Pacific in San Diego, using cybersecurity skills he developed at UTC to support U.S. Department of Defense research.
Strong Patient Outcomes Earns Holy Cross Health High Performing Recognition in U.S. News & World Report’s 2026-2027 Best Hospitals Rankings - Florida Hospital News and Healthcare Report
Five High Performing ratings recognize care for heart failure, pacemaker implantation and orthopedic procedures October 13, 2026 – Cardiovascular and orthopedic issues are two of the most common reasons patients seek […]
When 1 + 1 = 1: The Miserable Math Behind Many Media Mergers
(Welcome to the “Most Important Story of the Week”, my bi-weekly strategy column analyzing the most important (but often not buzziest) news story of the last two weeks. I’m the Entertainment Strategy Guy, a former streaming executive who now analyzes business strategy in the entertainment industry. Please subscribe.) The last few issues of this newsletter have circled two topics: September’s streaming viewership and all the Paramount/Skydance/Warner Bros./Discovery merger news. I’m happy to say on the Streaming Ratings Report front, we’ll be all caught up by early next week, then the SRR will come out on a tight weekly schedule. Then, after today, I’ll have slayed my PSWbD dragon. It’s such a big story, it demanded multiple issues. With the announcement of a name (just Skydance) and executive team, though, I think we can almost close the book on this story. In terms of topics, it becomes just another studio to cover. So today, I have one last set of takes on that merger. As I’ve sat with it, reading about who was staying and who was going, a big worry crystallized in my brain, and I gotta get that take out. Plus, I still owe you a host of “ugliness” that didn’t fit in my previous “The Good, The Bad and The Ugly” takes. Let’s dive in! Subscribe Most Important Story of the Week - As Paramount Shuffles Deck Chairs, Will They Build or Consolidate? On social media—I try to avoid most social media platforms, but sometimes I end up checking in—the best joke I saw about the announcement of the new name of Skydance was from fellow reporter Claire Atkinson who pointed out… Yeah, I laughed out loud at that one. Later, though, I saw another Twitter response (that later got deleted, so I can’t shout the person out) that did give me pause. The person noted that the Titanic film made the better analogy: a super expensive project everyone in the town doubted that went on to conquer the globe. So yeah: on one hand, the image of the Titanic recalls the actual ship and its infamous end, but that clip is from a movie which proved the doubters wrong. So for all the skepticism of the latest massive media merger, one could wonder which way this one goes. Does it crash like the Titanic or rise to glory like Titanic, the movie? Either way, this deal is “Titanic”, looking at the massive debt required to close the deal, which is not going well when it comes to borrowing costs for Paramount… …or borrowing costs for Oracle. But I’ve started to get worried about another outcome: the sum of this merger will be smaller and weaker and less profitable than its former parts. In other words, one plus one won’t equal three or two, but an even smaller number. Skydance paid to take a traditional studio off the board, but they won’t really capture the upside. Let me explain what I mean, but first, let’s look at the series of news that inspired this thought. Skydance Sets Its Leadership Team As soon as the Paramount-Skydance-Warner Bros.-Discovery merger closed, the new leadership team announced a new name—Skydance, which I’ll use going forward—and a new executive leadership team. You’ve probably read through all the executive shuffling, but if you haven’t, here’s a quick, incomplete summary, in rough order of importance: Mattel’s CEO Ynon Kreiz—who previously ran Maker Studios—joined as co-CEO with David Ellison. HBO/HBO Max’s Casey Bloys will stay and run streaming. Former head of streaming for Paramount-Skydance Cindy Holland—who was also at Netflix—will depart. The former heads of Warner Bros.—Pam Abdy and Mike De Luca—are out. The film studios will be run by Dana Goldstein and Josh Greenstein. George Cheeks of Paramount will run Skydance TV, controlling all the TV production units. In comic book news, the DC films will still be run by Peter Gunn and Peter Safran. Lastly, the head of CNN, Mark Thompson, will stay in place. Let’s quickly opine on the particulars before diving into the broad ramifications. We’re just getting started with this issue, but the rest is for paid subscribers of the Entertainment Strategy Guy, so if you’d like to find out… Who I like and dislike in their next gigs… Why I think this consolidation will likely leave Skydance worse off… The math behind which mergers succeed and which don’t… A lot more ugliness in this merger… And a whole lot more... ...please subscribe! We can only keep doing this great work with your support.
Science education needs its own evidence-based reckoning
Here's why science education needs an evidence-based reckoning to close learning gaps and improve student outcomes.
egnite's Call for Science Study on M-TEER Device Durability and Long-Term Patient Outcomes to be Featured at TCT 2026
/PRNewswire/ -- egnite, Inc., a cardiovascular intelligence company that helps clinicians identify and manage patients with untreated heart disease, today...
egnite's Call for Science Study on M-TEER Device Durability and Long-Term Patient Outcomes to be Featured at TCT 2026
egnite, Inc., a cardiovascular intelligence company that helps clinicians identify and manage patients with untreated heart disease, today announced that Dr. John T. Saxon, Director of the Advanced Cardiac Valve Center at University of Virginia (UVA) Health, has been selected as the winner of its inaugural Call for Science grant program. His study, Long-Term Durability After Successful M-TEER: Insights from a Large, Real-World Imaging Database, will be presented as Featured Clinical Research at
DNR Releases 2025-2026 Sustainability And Business Support Report
The Wisconsin Department of Natural Resources today announced the release of the Sustainability and Business Support (SBS) section's 2025-2026 report. The report highlights the many ways forward-thinking businesses, in partnership with SBS, are voluntarily outperforming regulatory requirements while achieving both superior environmental outcomes and operational efficiencies.
Citizens cuts Flutter Entertainment stock price target on unfavorable game outcomes
Citizens cuts Flutter Entertainment stock price target on unfavorable game outcomes
Dévy Rigaux’s aggressive summer approach has helped revitalise Feyenoord
Dévy Rigaux didn’t take long to begin making sweeping changes at Feyenoord. The former Club Brugge Sporting Director had barely been in post when he began making signings and replacing Robin Van Pe...
Sporting Judge to determine Malen’s suspension
Donyell Malen is preparing as best he can for tomorrow’s match at the Stadio Olimpico (9:00 PM) against José Mourinho’s Real Madrid. The Dutch striker is looking to shake off the disappointment o...
How Unilever tailors AI focus to business outcomes
“AI loves context, context loves data, that’s where we start,” said Allen Bates, SVP, chief digital and information officer, Unilever North America.
Key business issues are at stake in the outcomes of Colorado legislative races
Six House races and three Senate races likely will determine whether Democrats hold a supermajority in both legislative chambers in 2027.
Mekies Praises Verstappen’s Technical Sensitivity
The Austrian team director attributes the return to victory to the Dutchman's ability to identify the RB22's limitations.
Applications for N.C. rural health fund open next week, expanding healthcare access in rural communities
The N.C. Rural Health Innovation Fund aims to improve rural health outcomes through technological innovation.
Trusted support improves mental health in LGBQ+ teens
Gay or bisexual teens who have someone to turn to with a serious problem have significantly better mental health outcomes than those who don't, according to a new study from Tulane University researchers.
Court declines to rehear Outcome Health appeal from Shah, Agarwal
Shah and Agarwal were at the center of one of the most high-profile corporate fraud cases in Chicago history.
Having someone to talk to linked to better mental health among LGBQ+ teens
Gay or bisexual teens who have someone to turn to with a serious problem have significantly better mental health outcomes than those who don't, according to a new study from Tulane University researchers.
Meet our new faculty: Leo Martinez
Dr. Martinez’s research uses epidemiologic and quantitative methods to study tuberculosis prevention, transmission, and long-term health outcomes.
The voters who are fed up with Southwest Washington’s battleground Congressional race
Voters who dislike both candidates could play a key role in deciding the outcome.
Manchester City Victory and Celebrations Make Farce of Premier League
Liverpool manager Andoni Iraola described City’s 3-0 win as “two different games" as referring decisions decide outcome.
49ers report card from win over Seahawks: A+ for entertainment in latest entry of division rivalry
The 49ers’ defense stood out, forcing four turnovers to set up the offense well. The offense then came through in the clutch.
Business priorities for mobilising and scaling finance for biodiversity - ICC
COP17 provides a window to turn global biodiversity finance commitments into investment at scale. With at least US$200 billion a year needed for biodiversity by 2030, this ICC policy paper sets out the frameworks, financing solutions and market conditions needed to reduce investment risks and channel capital towards measurable outcomes for nature.
Characterizing the patient experience: The role of patient‑reported outcomes
Biological endpoints are essential, but on their own, they cannot tell the full story. To truly understand the value of a treatment and care surrounding it, we must also seek to understand how patients and carers experience it. This is where patient-reported outcomes (PROs) and observer‑reported outcomes (reflecting the perspectives of non-clinical caregivers) are becoming more prominent in clinical research.
Kirk Herbstreit Breaks Silence on Controversial Alabama-Georgia Ending
Saturday’s matchup between the Alabama Crimson Tide and Georgia Bulldogs was one of the more highly anticipated games of the college football season.And it more than delivered on entertainment value.Georgia escaped Tuscaloosa with a 20-17 win, but it wasn’t without drama.There were two defining moments that seemingly determined the outcome of the game. Perhaps none […] The post Kirk Herbstreit Breaks Silence on Controversial Alabama-Georgia Ending appeared first on HEAVY.
Judge orders Trump admin to stop airing challenged government-funded ads immediately
The ads have been criticized as government propaganda and as aimed at influencing the outcome of the midterm election, which will determine control of Congress.
Detroit Lions Get Brutal Tom Kennedy Injury Update
Detroit Lions WR Tom Kennedy was spotted on crutches with a long leg brace after suffering a knee injury against the Arizona Cardinals.
👀 Seedorf's Corinthians deal includes a relegation termination clause
Seedorf's contract with Corinthians provides for TERMINATION in the event of relegation to Série B.Announced this Sunday (11), the 50-year-old Dutchman joins—initially—on a contract running until...
Warm-Up Science Mapped: Nearly 1,000 Studies Reveal Where the Evidence Ends
A scoping review of 964 studies finds warm-up research dominated by short-term jump and sprint proxies, while injury endpoints, competition outcomes and real-world implementation remain strikingly underexplored.
Apple A20 outclasses Android rivals in our review: iPhone's lead is impressive
New iPhone 18 Pro reviewed! Our review shows what the flagship can do: a 2nm A20 Pro processor, 12 GB of RAM and a 6.3" ProMotion OLED display. Find out all about the camera upgrade (48 MP with a variable aperture), the long-lasting 4,056 mAh battery and faster 45-watt charging
These Midterm Races Will Decide Data Centers’ Political Fate
From the Senate to governors’ mansions, candidates are trying to outcompete each other to be the most anti–data center in races across the US.
This Workout Timing Shift Could Boost Your Health Outcomes
Wakey wakey, time to get your heart healthy
What Comes Next For Tencent Music After A 62% Slide
If you backed Tencent Music Entertainment Group for its fan economy story and smartphone tailwinds, the recent outcome would have been jarring. Holding Tencent Music Entertainment Group over the past year would have meant a 61.7% loss, including dividends. If you were weighing that decision on 9 October 2025, with analysts split between bullish digital growth and stricter rules plus margin pressure, which specific assumptions about user monetization, regulation, or offline events did the...
South Texas Health System (@stxhealthsystem)
3 likes, 1 comments - stxhealthsystem on October 10, 2026: "Serving Health, Healing & Hospitality: Proper nutrition plays an important role in the healing process, helping patients recover, regain strength and achieve better outcomes. Across South Texas Health System's acute care facilities and behavioral hospital, our Nutrition & Dietary Services teams work diligently each day to provide nutritious meals and exceptional service to patients, visitors and staff. During National Healthcare Foodservice Workers Week, STHS proudly recognizes the dedicated Nutrition & Dietary Services teams at STHS McAllen, STHS Edinburg, STHS Children's, STHS Heart and STHS Behavioral for their hard work, professionalism and commitment to excellence. From developing specialized meal plans that support patient recovery to serving every meal with care and compassion, these team members play an essential role in creating a positive healthcare experience. Their dedication to both nutrition and hospitality is felt throughout our hospitals and contributes to the quality, compassionate care our patients receive every day. Thank you for the care, kindness and pride you bring to your work. Your commitment helps nourish our patients, support our caregivers and strengthen the communities we serve.".
Breast cancer disparities can delay diagnosis and worsen outcomes, experts say
During Breast Cancer Awareness Month, experts are highlighting how cancer health disparities can affect identification, treatment and survival outcomes.
Casino UK: How Online Gaming Became Part of Britain’s Entertainment Mainstream
The UK has always had a particular relationship with gambling. From the betting shops that became fixtures of every British high street to bingo halls that served as social hubs for working communities, wagering on outcomes has been woven into British leisure culture for generations. What changed in the past decade was not the appetite,
AI Symposium on Research and Teaching Across the Humanities and Social Sciences
The College of Arts and Sciences is delighted to invite faculty, staff, and students from across campus to join us for the AI Symposium on Research and Teaching Across the Humanities and Social Sciences, scheduled on October, 29 from 9.00 am – 2.30 pm in the University Center Conference Room 315. The symposium will bring together… Continue Reading
Lazio Outcast Could Be Reinstated Ahead of Monza Game
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"That's not a real job": how one RCOB student turned soccer into a sports marketing career - Gary W. Rollins College of Business
Maia Pentecost is a marketing student at the Gary W. Rollins College of Business at the University of Tennessee at Chattanooga. Originally from Clarksville, Maia discovered her path into sports marketing in high school and has since turned that passion into a role as community relations coordinator for Chattanooga Red Wolves SC. In this student… Continue Reading
"That's not a real job": how one RCOB student turned soccer into a sports marketing career - Gary W. Rollins College of Business
Maia Pentecost is a marketing student at the Gary W. Rollins College of Business at the University of Tennessee at Chattanooga. Originally from Clarksville, Maia discovered her path into sports marketing in high school and has since turned that passion into a role as community relations coordinator for Chattanooga Red Wolves SC. In this student… Continue Reading
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IQVIA Launches IQVIA Life Science Models to Help Life Sciences Companies Predict Clinical Trial Outcomes
RESEARCH TRIANGLE PARK, N.C.--(BUSINESS WIRE)--Oct 7, 2026--
IQVIA Launches IQVIA Life Science Models to Help Life Sciences Companies Predict Clinical Trial Outcomes
RESEARCH TRIANGLE PARK, N.C.--(BUSINESS WIRE)--Oct 7, 2026--
IQVIA Launches IQVIA Life Science Models to Help Life Sciences Companies Predict Clinical Trial Outcomes
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Reliance Partners signs on as Gold-Level Partner of John "Art" Phillips Sales Institute - Gary W. Rollins College of Business
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Brazil: Lessons from a Disaster
By Antonio Martins (Outras Palavras) Defeats become deeper and more prolonged when we misunderstand what caused them, avoid correcting course, and embrace “solutions” that only compound our mistakes. Lula’s government and the Brazilian left suffered a disaster in Sunday’s election. Contrary to every poll, the president finished the first round 2.2 million votes behind Flávio Bolsonaro—and, more significantly, 3.4 million votes below his total four years ago, when the machinery of the state was working against him and in favor of his opponent. His vote share declined in 98 percent of Brazil’s municipalities. The PL, the main party of the far right, elected 121 deputies and 28 senators, becoming the largest caucus in both houses of Congress. The parties aligned with the Centrão—Brazil’s bloc of transactional center-right parties—were somewhat diminished, but will still hold roughly 250 seats in the Chamber of Deputies and 35 in the Senate. That will make it easier to assemble the majorities needed to amend the Constitution or impeach Supreme Federal Court justices. If elected, Flávio Bolsonaro could appoint four members of the Court, substantially altering its internal balance of power. What produced these results? How can the far right be prevented from consolidating them into a prolonged political hegemony? And what is the essential change of direction the left now needs? Explaining the Disaster Across the commercial media and the exuberant chaos of digital platforms, interpretations are multiplying. Some focus on specific episodes: Lula’s absence from the Globo debate, his very close relationship with Alexandre de Moraes, or his emphasis on issues supposedly remote from most people’s everyday concerns, such as rare earth minerals. Among the more systemic interpretations, three seem especially questionable. One argues that the principal defeat was not the left’s, since its congressional representation declined only slightly. The decisive movement captured at the ballot box, according to this view, was a shift within the right itself—from the more moderate and transactional forces of the Centrão toward the more ideological and radicalized forces of the PL and Novo. A second interpretation holds that the nature of electoral and political processes has changed. The material interests and aspirations of society, it argues, no longer play the central role they once did; they have given way to forms of subjective self-identification that the left has yet to understand. And a third concludes that, because of these two developments, we should expect a political winter: a prolonged period in which the far right and the broader right dominate Brazilian political life. There are important elements in all three interpretations. The problem lies in what they deny or leave out: Lula’s third government was a small-bore government. It offered the majorities that elected it neither a clearly better life nor reasons to believe again in politics and its power to transform society. These failures flowed from two fatal accommodations, which I will examine below. As a result, the government suffered a slow but steady erosion of support. And, as has happened in so many Western countries, it gave the far right the opportunity to present itself as anti-system and to benefit from popular frustration and distress. The interpretation that emphasizes the migration of votes from the center-right and traditional right toward the far right has been advanced, among others, by the courageous journalist Leonardo Sakamoto. In his UOL column on Monday, October 5, he highlights the miserable behavior of the traditional conservative parties. Over the past four years, they repeatedly joined forces with the “neo”-fascists, helping to “normalize” them—a criticism that could equally be directed at almost the entire corporate media. Believing they could use the far right as a stepping stone, they instead ended up partly devoured by it. This was especially true in the Senate, where the PL’s gain of 13 senators and Novo’s gain of two came at the expense of the PSD, which lost nine; the MDB, which lost two; the PSDB, which lost two; and the PP, which lost one. Sakamoto’s observation is accurate and necessary, but it leaves uncomfortable questions unanswered. Why did the erosion of the Centrão benefit the far right rather than, for example, producing growth for the left—as has happened so many times before, both in Brazil and elsewhere? The answer is not difficult. Throughout its four years in office, Lula’s third government was almost invariably associated with the Centrão. Here lies its first accommodation: accepting the limits imposed by conservative institutions; avoiding, as much as possible, any attempt to strain those limits through popular pressure; and believing only in the modest changes that could be squeezed through openings in Congress. The failure of the campaign to end the six-day workweek is emblematic. Lula could have electrified the presidential race by pairing it with a popular campaign for passage of the measure. Instead, he chose to place his hopes in the hands of Senate president Rodrigo Alcolumbre. He generated no mass mobilization, did not force his opponents onto an uncomfortable defensive, and won no victory. In September 2025, the government squandered the greatest of its many opportunities to shake up conservative power in Congress. Popular opposition to the so-called Shielding Amendment—which, if approved, would have restricted criminal proceedings against members of Congress—brought crowds into the streets, mobilized primarily by artists and social movements. This opened the possibility for a broader political education: a campaign that could begin exposing the limits and dysfunctions of Brazil’s political system while putting Bolsonaro’s movement on the defensive for its predictable support of political privilege. The amendment was defeated. But the executive branch then backed away from the fight. It remained associated with an institutional world widely seen as corrupt, elitist, and indifferent to ordinary people’s struggles. In doing so, it forfeited its credibility as a vehicle for the protest vote. On Sunday, it reaped the bitter fruits. Are We Doomed? Taking a different approach from Sakamoto, the philosopher Moysés Pinto Neto and other writers have drawn attention, in their first analyses of October 4, to the fragmentation of the public sphere produced by Big Tech platforms. Through their algorithms, these platforms present each person with a different view of social reality. As a consequence, it becomes much harder to identify common material problems and demands—for example, the fight for labor rights or for a properly funded public health system. Voters no longer embrace such demands, these authors argue, because they no longer see themselves as part of a collective. Instead, they tend to value the identities assigned to them by neoliberal subjectivity—the role of the entrepreneur, for example. On this interpretation, the left’s possible error lies in clinging to outdated illusions. Moysés’s warning is highly relevant and resonates with arguments such as Naomi Klein and Astra Taylor’s “Apocalyptic Fascism and the Billionaires’ Bet.” Unlike a century ago, the far right no longer promises a radiant future. It concentrates instead on resentment—especially that of young men. “They belong to a generation that fears it may never own a home, but compensates with the pleasure it gets from constantly provoking progressives online. Convinced their future has been stolen, they share memes romanticizing historical authoritarian regimes,” the authors write. But Moysés seems to confuse this danger with inevitability. He fails to see that the left’s answer cannot be adaptation. On the contrary, it must strengthen the possibility of politics as collective action. Nor does he recognize that precisely such a reversal is already becoming possible in some of the most promising mobilizations of the twenty-first century: the election, at the end of 2025, of the young Muslim Zohran Mamdani as mayor of New York, on a platform centered on the intensely material fight for an affordable city; the Left Party’s victory in Berlin two weeks ago, built around the demand to expropriate private real-estate corporations; and the very recent wave of demonstrations in Spain—including an occupation of Madrid’s Puerta del Sol—in which tens of thousands of young people mobilized by the Tenants’ Union have demanded limits on rents. By putting itself in the straitjacket of the “fiscal framework” in the first months of 2022, Lula’s third government adopted the second fatal accommodation of its term. Faced with conservative institutions and a country devastated by four years of Bolsonaro, increased public investment was the government’s remaining weapon for offering a more dignified life to the majority and forging an anti-conservative pact with them. The same state that disburses 1 trillion reais a year to enrich a small class of rentiers could instead spend money to extend the Family Health Strategy to every Brazilian, at a cost of 30 billion reais; provide full-day public schooling and childcare to all adolescents and children—and, especially, relief to their mothers; achieve universal sanitation while cleaning up polluted urban rivers; multiply metro systems; begin transforming the urban peripheries; and undertake many other urgently needed projects. In April 2023, an article in Outras Palavras warned that the fiscal framework could “shrink the Lula government and preserve the forces that condemn the country to inequality and regression.” A year later, another article showed that restraints on public spending were strangling policies vital to ordinary people and undermining the president’s popularity. In November 2024 came a reality check, in the form of the government’s humiliating defeat in the municipal elections. Even then, the fiscal lock was neither removed nor loosened. On the contrary: throughout the government’s four years, fiscal restraint remained central to its political narrative. The administration proudly proclaimed that it had “put the state’s accounts in order,” without grasping either how misleading that phrase was—given the payment of 1 trillion reais in interest—or how badly the message was hurting it politically. Lula finally woke up in September 2026. The increase in Bolsa Família benefits, after four years of being frozen; the announcement that anti-obesity drugs would be offered through Brazil’s public health system; and the ban on online betting showed that the state has the power to act decisively on behalf of the majority when those in government are willing to confront obstacles. The huge marches that closed the campaign in Fortaleza, Salvador, Rio de Janeiro, and São Paulo on the eve of October 4 showed how such initiatives can mobilize activists and the broader public. But it was too late—and too little to change the outcome of the first round. History has not ended The possibility of a turnaround in the three weeks leading up to November 25 cannot be ruled out. It will not be simple or easy. Lula must not only make up a deficit of 2.2 million votes; he must also offset the movement of voters who backed other right-wing candidates in the first round, most of whom are likely to move toward Flávio Bolsonaro. Pulling that off will require a broad, grassroots effort to win over voters, potentially reinforced by new initiatives from Lula. The coming hours and days will be decisive. If Bolsonaro’s movement also wins the presidency, the result will create a high-risk situation for Brazilian sovereignty and democracy. The enormous challenges posed by such an outcome would require the left to reexamine, in depth and with a genuine willingness to engage in self-criticism, its political projects—or its lack of them—and its practices. But would that mean we are condemned to the long winter of far-right hegemony that some analyses are beginning to forecast? It is far too early to say, suggests a recent text by Álvaro García Linera, the thinker who served as vice president of Bolivia under Evo Morales. His central hypothesis is that this political current will prove short-lived. At a moment when the entire world is once again talking about sovereignty and protecting national economies, the far right offers a stale, recolonizing neoliberalism. Its submission to the United States is as blatant and pathetic as Flávio and Eduardo Bolsonaro’s overtures to Donald Trump. Its project amounts to something like every man for himself: greater inequality, capitalism without limits, devastation, and supremacism. Will it work? In the United States, just two years into his second term, Trump himself is reaching record levels of unpopularity and may be on the verge of losing Republican control of both the House and Senate in November. Every new beginning is difficult. Whatever the outcome of the second round, the defeats of October 4 show how profoundly the Brazilian left will have to rethink and rebuild. But just as it would be foolish to underestimate the seriousness of its mistakes, it would be equally foolish to conclude that rebuilding a political project is no longer possible. History has not ended. The times are moving faster than ever. Originally published in Portuguese by Outras Palavras. English translation by Eric Blanc; I’ve added the subtitles. More We can’t stop the far right at home or abroad without a revitalized labor movement, which is yet another reason why you should become a sustaining supporter of the Emergency Workplace Organizing Committee (EWOC) — one of US labor’s pivotal bright spots. Relatedly, Jacobin published a short piece of mine reflecting on a decade of Bernie Sanders inspiring a whole new generation of young worker organizers.
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Yale School of Medicine On the Science of Childhood Anxiety, Say, Anxiety Disorders Are the Most Common Mental Health Challenges In Youth
Credit: Matt Bradbury October 5, 2026 - By Isabella Backman - Anxiety disorders are the most common mental health challenges in youth. Left untreated, they can disrupt the lives of both children and their families. The good news is that with intervention, most children will overcome these conditions. Across Yale School of Medicine, scientists are working to understand anxiety at every level, from common anxious behaviors to molecular biomarkers in the brain. They are using their findings to develop and disseminate new evidence-based treatments for childhood anxiety. Today, the go-to treatment for childhood anxiety disorders is cognitive behavioral therapy (CBT). This is a form of psychotherapy that teaches children skills for confronting anxious thoughts and helps them practice managing situations that cause anxiety. While it is the gold-standard treatment backed by considerable scientific evidence, up to 50% of children will not see sufficient benefit from CBT alone. Wendy Silverman, PhD, Alfred A. Messer Professor in the Child Study Center, co-directs the Anxiety and Mood Disorders Program alongside Eli Lebowitz, PhD, associate professor in the Child Study Center. One of their main interests is learning how to improve outcomes beyond CBT. “We’re developing cutting-edge, research-based knowledge that can reduce the suffering that anxiety causes children and their families,” says Silverman. Changing parent behavior YSM experts are investigating how to improve CBT outcomes for children by involving the parents. Silverman’s research has uncovered two main components of parent intervention that improve childhood anxiety: not enabling children to completely avoid the things that make them anxious and taking steps to enhance their autonomy. Parents may unintentionally reinforce their child’s anxiety by allowing them to avoid what makes them anxious. They also may unintentionally limit the children’s sense of autonomy by being overly intrusive. “One of the things that we take pride in is that we’ve focused on trying to understand what parents need to do, and to test our ideas and see if changing the parents’ behaviors is enhancing the effects of CBT,” Silverman says. “Our findings thus far suggest that they do." As much as CBT can be helpful, it can also be challenging to get one’s child to do the necessary steps for CBT to work. This is one important reason why Lebowitz created a novel intervention program for parents named Supportive Parenting for Anxious Childhood Emotions (SPACE). Existing intervention programs often teach parents to act as therapists for their child, such as training them on how to practice breathing exercises. “It makes sense, but this doesn’t work very well in practice,” says Lebowitz. “And part of the reason, I think, is that it’s not easy to get your kid to do things, especially if they’re not excited about doing it.” SPACE is unique because it focuses entirely on parent involvement and changing parental behavior—children are not involved in the sessions. For example, parents learn how to use supportive messages that convey confidence that their child can tolerate and manage distress. “It might sound like a parent saying to a child, ‘I get that this is really hard for you, but I know that you can handle it,’” Lebowitz says. The program also works with parents to identify the ways in which they are accommodating anxious behaviors. “We’ll pick one thing that parents are doing that is an accommodation and help them make a detailed plan for how they’re going to change that,” Lebowitz explains. Treating Anxiety in Children and Adolescents Much of the existing research on SPACE has focused on parents of children under age 14. Ongoing studies are now exploring its use with parents of older teens. “Both anxiety and accommodation can interfere with normative developmental shifts during the teen years, including increased autonomy and individuation from parents,” says Rebecca Etkin, PhD, associate research scientist in the Child Study Center. “In this sense, SPACE may be particularly well-suited for anxious teens and their parents. We want to see whether it is effective during this distinct developmental window.” Unfortunately, many families in need of CBT face barriers, including limited availability of services and geographic constraints. One way to improve access is digital interventions. Silverman and her team are developing an evidence-based digitized intervention program for parents that they can access directly from their computer or smart phone. “The work we’re doing will be one of the very few parent interventions that is digitized and importantly tested for effectiveness,” she says. Creating interventions for anxiety-related challenges Silverman and Lebowitz recently received a generous gift to develop and test other interventions that help parents reduce other child anxiety-related behavioral and emotional difficulties, such as restrictive eating and unexplained somatic symptoms. One of these projects in particular focuses on understanding the risks of social media and its potential benefits, including offering a sense of connection. “A lot of research has focused on the idea that social media is harmful and the less of it the better,” says Lebowitz. “But we actually see is that this is not quite right—there are negatives, but there are also positives. So, we’re trying to get a little bit more nuanced of a picture.” The team is working with teens with social anxiety and their parents over an extended period to better understand their social media habits and how their anxiety levels affect engagement with different platforms. The teens will answer questions sent to an app on their phones about mood and social media usage in an effort to capture emotional responses as they unfold. “We hope to develop interventions that can help make the best of social media while protecting against the more problematic effects,” Lebowitz says. The brain’s role in anxiety Researchers are also testing therapies to address anxiety at the neurological and molecular levels. In collaboration with Dylan Gee, PhD, professor of psychology in Yale's Faculty of Arts and Sciences, and Hilary Blumberg, MD, John and Hope Furth Professor of Psychiatric Neuroscience at Yale School of Medicine, Lebowitz and Silverman are using brain imaging to identify changes in a child’s brain before and after parents enroll in SPACE. In one study, children viewed anxiety-inducing images while undergoing magnetic resonance imaging (MRI); the researchers conducted scans with and without the children’s parents nearby. Before SPACE, children’s brains were better able to activate the regulatory circuitry needed to turn off an anxious response when their parents were nearby. But after SPACE, children could activate this circuitry even without the parent around. “As parents work on gradually reducing some of their accommodations, you can see a child get better at regulating their own fear system in the brain,” Lebowitz says. “It’s remarkable.” Research into the molecular underpinnings of anxiety can also inform new childhood anxiety treatments. In a recent study, Lebowitz, Silverman, and Flora Vaccarino, MD, Harris Professor in the Child Study Center, discovered that a protein known as fibroblast growth factor 2 (FGF2) could be protective from the toxic effects of stress. FGF2 levels in children and their parents were linked to the children’s risk of developing anxiety and depression, the study showed. The findings could help explain why some children who are exposed to early life trauma such as poverty or abuse are more prone to developing mental health disorders. And FGF2 could be a target for treatment. “This is very novel because it starts to give a clue to what is the molecular chain that connects those lived experiences to the actual psychological outcomes,” Lebowitz says. New ways to study and treat childhood anxiety Michael Crowley, PhD, associate professor in the Child Study Center, collaborates with Silverman and Lebowitz to study the role that attention plays in development and maintenance of childhood anxiety. There is a large body of research that shows that anxious children, like anxious adults, are prone to focus on threatening stimuli such as angry faces compared with neutral faces. This has led to innovative interventions that involve attention retraining. The idea is that if experts train children to look away from threatening stimuli, it may reduce their anxiety—especially children with social anxiety who are most prone to attend to threats. The researchers have just completed a clinical trial for attention retraining with 10- to 14-year-olds with social anxiety disorders and are currently analyzing the findings. Besides this innovative attention retraining research, as Crowly notes, “I like to design tasks that are engaging to kids,” Crowley says. “My goal is to assess something without the kids knowing what we are assessing.” With this goal in mind, Crowley has created a virtual game, named Boom, to study threat processing in children with anxiety disorders. The game is similar to that of hot potato—the child and three digital players take turns virtually passing a ball to each other’s gloves. At some point, the ball turns into a bomb, and as the bomb lands in each player’s glove, the outline of the glove turns yellow. The goal is to avoid having the bomb go off in your glove. What isn’t obvious is that the game is designed to measure different types of threatening stimuli, both ambiguous and direct. In the game, the direct threat occurs as the bomb is traveling towards your glove. The ambiguous threat is the yellow outlined glove as it is unknown where the bomb will travel next. While children play the game, Crowley’s team measures their brain activity using electroencephalography (EEG). The researchers have discovered that in kids with anxiety, the brain reacts more strongly to ambiguous threats than it does in their peers, but less strongly to direct threats. They believe that the initial abnormally large brain response to not knowing where the bomb is going impairs the brain's ability to properly respond when the threat is actually traveling the child’s way. “The brains of children with anxiety are unable to differentiate between threats you need to do something about and those that are not your problem.” Michael Crowley, PhD, develops innovative games for studying anxiety in children and adolescents.Credit: Matt Bradbury Based on these insights, Crowley hopes to study whether interventions like attention training could restore appropriate threat processing. Crowley’s team is also working on a test called the Balloon Risk Avoidance Task, which evaluates risk-taking and avoidance behaviors. It features a digital balloon that is full of air and about to burst. Kids have six seconds to let air out of the balloon. The more air they let out, the less risk they face that the balloon will pop. But at the same time, the balloon becomes less valuable as it deflates. “The more air you keep in the balloon, the more points you get,” Crowley explains. So far, the researchers have found that when the balloons pop unexpectedly, teens with social anxiety show distinct brain responses. Studying these responses can help psychologists understand the underlying pathways driving the various manifestations of anxiety. The genetics of anxiety When Thomas Fernandez, MD, associate professor in the Child Study Center and of psychiatry, was still in training, there was a lot of excitement about understanding the genetics associated with autism spectrum disorder. Since then, scientists have identified around 250 genes associated with autism. The genetic contribution to anxiety disorders, on the other hand, has historically received less attention. Anxiety is less heritable than autism, but the genetic contribution for anxiety disorders that emerge in childhood may be higher than for anxiety disorders overall. While scientists estimate the heritability of anxiety disorders in general to be around 30% to 50%, some studies suggest higher heritability for certain childhood-onset anxiety presentations. “I saw firsthand how researchers in the field went about finding vulnerability genes for autism,” Fernandez says. “So, we’re using a very similar playbook for childhood anxiety.” “I saw firsthand how researchers in the field went about finding vulnerability genes for autism. So, we’re using a very similar playbook for childhood anxiety.” Thomas Fernandez, MD Associate Professor In the Child Study Center and in Psychiatry Now, Fernandez and Emily Olfson, MD, PhD, assistant professor in the Child Study Center, are studying children and their parents to identify genetic changes that are present in the child but not the parents, known as “de novo mutations.” “All of us have some de novo mutations—maybe about 50 to 100 sprinkled throughout the genome,” Olfson says. “But when they occur within the coding regions of genes, they can be really disruptive.” Previous research shows that people with autism have higher rates of damaging de novo mutations than the general population. In 2022, Olfson, Lebowitz, Silverman, and Fernandez published a study on 68 children and their families that found that children with anxiety had similarly high levels of these mutations. Studying de novo mutations can help point the researchers to where they should be looking for genes associated with anxiety. “The end game is using the genes to steer us toward the right part of biology that we can then target to come up with better treatments,” Fernandez says. Building on those findings, the team is now studying more families to better understand how these de novo mutations, along with other genetic and environmental factors, shape pediatric anxiety disorders. They recently received a National Institutes of Health grant to enroll 750 new families over the next five years. Olfson is the principal investigator, with co-investigators Lebowitz, Fernandez, Silverman, and Shuangge Steven Ma, PhD, department chair and professor of biostatistics at Yale School of Public Health. Neurodevelopment, Risk Genes, and Mental Health Conditions - The Olfson Lab Joel Gelernter, MD, Foundations Fund Professor of Psychiatry, is interested in how different anxiety disorders differ genomically. “We are studying social phobia, panic disorder, and generalized anxiety disorder, working to understand why people differ in their risk to these specific anxiety disorders and evaluating various risk factors,” he says. Gelernter was recently involved in one of the largest studies to date of the genomics underlying anxiety disorder. The study included around 122,000 people with anxiety disorders and around 730,000 without. It found that some genetic differences associated with anxiety were linked to signaling that helps reduce overactivity in the nervous system. Many anxiety medications available today work by targeting this process. “It’s nice when the biology that you get out of a large genome-wide study ratifies things that we already know because that can help increase confidence in further findings from the study,” Gelernter says. Uncovering the neurobiology of psychiatric disorders John Krystal, MD, Robert L. McNeil, Jr. Professor of Translational Research and chair of the Department of Psychiatry, is interested in the neurobiology of psychiatric disorders, including post-traumatic stress disorder (PTSD), of which anxiety is a major symptom. In the late 1980s, Krystal’s team discovered that the drug yohimbine activated symptoms in patients with PTSD. “This was the first time we could link a specific biological mechanism to the symptoms of PTSD,” Krystal says. At the time, he adds, this finding was highly controversial. “A lot of people felt that PTSD was a purely psychological syndrome that didn’t have an underlying biology.” Since then, Krystal has dived deep into understanding the neurobiology of PTSD to learn how to better treat it. His team is evaluating the use of ketamine and psychedelics. These would be among the first treatments to be developed specifically for PTSD. They may also be applicable for other disorders including anxiety disorders, Krystal adds. An important gap in PTSD treatment is the absence of biological tests that inform how to best help patients manage their PTSD symptoms. A doctor doesn’t diagnose cancer based on how they feel. Rather, they use tests of the biology of the cancer to determine the best course of treatment. “And we can’t do that in any psychiatric disorder other than Alzheimer’s disease,” Krystal says. “But now we are building a foundation for this approach to the treatment of anxiety disorders for the first time.” Source: Yale School of Medicine
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