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📈 Monday data: The bottleneck isn’t intelligence
In the AI Investment Brief today: CapEx updates and lease commitment breakdowns Anthropic co-founder Jack Clark recently said in a speech at the IMF that the singularity has begun: For many years, researchers and science fiction authors have forecast a future in which AI systems drastically increase the pace of overall scientific and technical progress, making things move so quickly that it is hard for humans to keep up. They call this the singularity. I believe that this year we have gained convincing evidence that it has now begun. This follows Anthropic’s claim that in August, 26% of its AI R&D was led by Claude, with a human supervising its work. In October, OpenAI posted 719 math manuscripts1 made by its internal model. Math and coding are two fields where a research loop can close without leaving the desk. But can the loop close in the rest of science? Subscribe The loop is real The idea is not new. Mathematician Irving John Good, who had worked with Alan Turing at Bletchley Park, argued that a machine smarter than us “could design even better machines; there would then unquestionably be an ‘intelligence explosion,’ and the intelligence of man would be left far behind.” The Gödel machine, a self-improving computer that can rewrite its own code better than its prior, was first proposed in 2003. In 2025, researchers at Sakana AI and the University of British Columbia set out to show that this was possible. Their agents iteratively improved their own code through a feedback loop, resulting in gains of 30 pp on SWE-bench and more than 15 pp on Polyglot, testing coding skills beyond Python. The idea has since been tested in other labs. A Gemini-powered agent called AlphaEvolve found a faster matrix multiplication kernel used for training Gemini, speeding up the kernel by 23% and cutting Gemini’s training time by 1%. In China, MiniMax reported that its M2.7 model worked on improving its own agent’s harness, skills, sampling and memory. Over 100 rounds of rewriting led to a 30% gain, per its internal evaluations. In each case, what was being rewritten was not the model itself but everything around it. Is it better than human work? In September this year, in what seemed like a milestone, an AI-built agent proved as good at improving other AI agents as a human-built one. It did that in what appeared to be half the steps. But the result was inconclusive: the differences between runs were greater than the difference between the AI- and human-built agent results. Nonetheless, this is increasing the chatter around recursive self-improvement (RSI) in AI. Google’s Sundar Pichai said that “you have RSI loops along with AI researchers in various aspects of model development.” Sakana AI published a paper on RSI through multi-agent collaboration, finding that after two cycles its system scored 1.2–1.6x better per output token than the base model across four research benchmarks. Ramez Naam challenges that view. He splits AI self-improvement into five overlapping types. The first four describe how autonomous the AI is; so far, only types 1 and 2 have been observed. The fifth type describes accelerating returns, and he notes that greater autonomy doesn’t guarantee a takeoff scenario. Instead, each round of self-improvement would need to deliver at least as much as the last. The results from Sakana, AlphaEvolve and MiniMax above might look like type 3 or type 4 autonomy. But in each case, the AI wasn’t updating its own weights directly, only the ancillary parts — the harness, the memory. And where Claude leads its own R&D, for now a human still supervises.
Audi Builds in Georgia, and the Politics Come With It
The German luxury brand plans a $4 billion US factory to escape punishing import tariffs, but its CEO’s appearance alongside Donald Trump has turned a strategic manufacturing decision into a governance headache back home.
Joe Burrow Silences Fans Who Called Him ‘Washed’ and ‘Overrated’ as Bengals Shut Down Ravens
Fans have learned not to count out Joe Burrow too quickly. The Cincinnati Bengals quarterback, 29, and his team had what The Athletic described as one of their worst offensive halves in recent history against the Baltimore Ravens on Sunday, October 25. Burrow went 6 of 12 passing for 43 yards in the first two […]
Lunin: “Discipline, attitude and determination were key”
Real Madrid backup goalkeeper Andriy Lunin talked to the club’s media after starting in Madrid’s 2-1 victory at the Camp Nou. “Discipline and attitude were key because Barcelona had more possession. Also, the determination because playing away is tough, and today these three points were important because we all knew how things stood. Teamwork was […]
NASA's Swift Observatory Ends Its Science Mission
NASA's Swift observatory made its last observation on Oct. 20 after 22 years, 2,000-plus gamma-ray bursts and about 7,000 papers.
Europe takes cancer science into immunology
Inspired by technology and insights gleaned from cancer research, Europe is leading the quest for a new generation of therapies in immunology and inflammation. Immunotherapy has revolutionised cancer therapy and become standard of care in many areas of oncology but it has also begun to change outcomes in inflammatory and autoimmune diseases.
Intermountain Health wants women to prioritize mammograms with simplified online scheduling
Thanks to recent upgrades at Intermountain Health, it's easy for women to schedule an appointment for their annual screening mammogram.
Multiple Vulnerabilities Identified in Component Used by Smile Digital Health’s Smile CDR
Four vulnerabilities have been identified in HAPI FHIR, the open-source Java library and server framework that implements the HL7 FHIR standard, that Four vulnerabilities have been identified in the HAPI FHIR open source component used in affect Smile Digital Health’s Smile CDR clinical data repository and health data platform.
Celebrate the flavors of fall with three spicy recipes
A new book offers a history lesson with every spice.
Federal Water Tap, October 26, 2026: EPA Science Advisers Weigh In on Drinking Water Regulatory Process
The Rundown And lastly, the interior secretary says that Arizona’s Colorado River cuts are manageable over the next two years. “The allocation that’s been made, given the constraints we have and the commitments we have to make and the Law of the River, as it’s called, that this is a very positive outcome for Arizona […]
New Guidance on Reproductive Health and Cystic Fibrosis
Updated clinical guidance outlines family planning, prenatal monitoring, and fertility care for patients living with cystic fibrosis.
In brief: Orlando Bloom, Elijah Wood joining 'The Gentlemen'
Netflix is rounding up more gentlemen. Tudum announced Orlando Bloom, Elijah Wood and Ed Speelers are joining stars Theo James and Kaya Scodelario for the third season of The Gentlemen, which is currently filming in the U.K. and Morocco. Also added to the series cast are Dexter Fletcher, Robert Carlyle and Bugzy Malone, who appeared in the 2019 film that inspired the Netflix series. Daniel Ings, who played the drug-addled older brother Lord Frederick “Freddy” Horniman to James’ criminal mastermind Eddie Horiman, told HATC magazine he will not return for the third season. Netflix has not confirmed this …The action-adventure series Fallout has inspired a new reality show. Prime Video has revealed Fallout Shelter: The Experiment, an unscripted competition inspired by the post-apocalyptic drama series and the video game universe. The show “invites everyday participants to test their aptitude for the apocalypse in Vault-Tec's state-of-the-art bomb-proof vault shelters," according to Prime Video. Contestants will “go head to head in a series of high-octane drills, psychological dilemmas and morally challenging behavior trials.” The winner walks away with a $1 million prize. Fallout Shelter: The Experiment will begin streaming in January 2027 … TNCMS.AdManager.render({region: 'fixed-big-ad-top-asset', slot: 1, fold: "above"}); Bravo renewed a slate of its reality shows ahead of Bravo’s Fan Fest on Saturday. New York-based In the City has been greenlit for season 2, while Next Gen NYC is coming back for a third season. For viewers seeking a little Southern charm, The Next Gen universe will be expanding with a spinoff based in Atlanta, and Southern Hospitality is moving forward with a fifth season. Premiere dates have not yet been announced … Copyright © 2026, ABC Audio. All rights reserved. Thank you for reading kmaland.comAt KMA, we attempt to be accurate in our reporting. If you see a typo or mistake in a story, please contact us by emailing kmaradio@kmaland.com.
Brazil's Lula celebrates election victory as Bolsonaro rejects results
Luiz Inacio Lula da Silva has won a historic fourth term after defeating far-right rival Flavio Bolsonaro in a runoff election. It's a remarkable political comeback for Lula who trailed in the first round.
‘Disturbing and pathetic’: German politicians slam Audi CEO’s appearance at Trump rally
The German car manufacturer plans to open a factory in the U.S. state of Georgia.
PHOTO STORY: Explora blends science and the spooky for Halloween ‘Adult Night’
Getting into the Halloween spirit, Explora Science Center and Children’s Museum hosted an Adult Night on Oct. 16. Explora created an event for audiences 18 and over to enjoy a spooky, Halloween-themed night filled with crafts and events for adults to have fun. Costumes were encouraged, and many guests showed up in a variety of unique outfits.
Kennesaw State researcher explores virtual reality to improve student engagement in STEM
A Kennesaw State University researcher is exploring how virtual reality can help students stay focused and engaged during science and engineering laboratory activities. Supported by a $198,486 grant from the National Science Foundation (NSF), the research aims to help learners maintain attention, improve motor skill, and enhance learning in immersive virtual laboratories. Sungchul Jung, an assistant professor of gaming in KSU's College of Computing and Software Engineering, is leading the two-year project.
Iranians pin hopes for political change on Netanyahu's election win
Iranians are looking to Israel's election as a potential turning point in their country's political future, with supporters of Benjamin Netanyahu hoping his victory will bring renewed pressure on the Islamic Republic.
Chicago Cubs history unpacked
On this date, the Cubs’ Ferguson Jenkins won the 1971 National League Cy Young Award.
Universal Health Services earnings: what to look for from UHS
Hospital management company Universal Health Services (NYSE:UHS) will be announcing earnings results this Tuesday after market close. Here’s what to expect.
Think your boss is bad? Scientists identify history’s first official ‘corporate psychopath’
People motivated by power, wealth, and personal advancement were attracted to capitalism from its earliest days
Two encouraging stats after Inter’s latest comeback victory
Inter had to come from behind yet again to claim a 2-1 victory over Fiorentina in Serie A on Sunday afternoon, which has kept the Nerazzurri at the top of the league table for another week and has pro...
Serbia's political veteran Vucic outplayed all opponents. Then the students came
Serbia’s populist leader Aleksandar Vucic has dominated politics in the Balkan country for 14 years
The extraordinary life of Holden Trent, who defied the odds to play the sport he loved
Holden Trent went 'through a battle every single day to be the person he was'. This is his story, told by those who knew and loved him
Analysis | Saddam’s Cheesecake Factory: Trump’s predecessors go after him in ways only they can
In today’s edition … Voters are changing their minds … You tell me about your first time voting … but first …
Today’s Papers: Juventus claw back, Inter never give up
La Gazzetta dello SportKimi, here we go Another triumph, the World Championship will arrive on Sunday with a ninth-place finishAntonelli also dominates at the GP in Austin: His ninth victory. The tit...
Mbappé: “This was a team win”
Real Madrid star Kylian Mbappé talked to Real MadridTV after Los Blancos conquered the Camp Nou with a 1-2 victory where he scored both of the team’s goals. “It is a team victory. The protagonist of the match is the team and the group because we knew we had to play a strong game, but […]
The youngest Ballon d’Or winners in history
Ronaldo Nazário remains the youngest player to win the Ballon d'Or, having claimed football's most prestigious individual honour aged just 21 years and 92 days in 1997.But could the Brazilian's long-...
PROFILE - From prison to historic 4th term: Brazil's Lula extends extraordinary political career
Former factory worker and union leader secures another mandate after decades marked by electoral victories, corruption investigations and political polarization | Anadolu
Goldwind Science & Technology: 9M26 profit reached RMB2.9 billion as WTG sales rose and backlog hit 57.0 GW
9M26 revenue was RMB52.0 billion and attributable net profit RMB2.9 billion. WTG sales rose 3.02% YoY, while total backlog reached 57.0 GW; operating cash flow was negative RMB30 million.Original document: Goldwind Science & Technology Co. Ltd. Class A [002202] Slides Release — Oct. 26 2026This is…
Marco Rubio’s Greek Panegyric / Celebration: Political Theory and Praxis
Prologue Translating the ideals of Greek history, politics, democracy, theater, athletics, the Delphi peace vision, philosophy, science, technology,
Chiefs Announce Historic Travis Kelce News During Seahawks Game
Kansas City Chiefs tight end Travis Kelce can’t stop making NFL history.With his third reception in the fourth quarter against the Seattle Seahawks on Sunday night, Kelce has passed Hall of Famer Tony Gonzalez for the most receiving yards by a tight end ever, including the postseason, with 13,342.Kansas City Chiefs’ Travis Kelce is Most […] The post Chiefs Announce Historic Travis Kelce News During Seahawks Game appeared first on HEAVY.
Luka Doncic Makes NBA History in 50-Point Game in Lakers-Magic
Los Angeles Lakers superstar Luka Doncic was on a different level against the Orlando Magic.
Derrick Harriott shaped and preserved our music
Minister of Culture, Gender, Entertainment and Sport Olivia Grange has said that, with the death of Derrick Clifton Harriott, Jamaica, sadly, has lost another of the icons who helped to shape the trajectory and reach of the country’s musical genres. Derrick Harriott was a producer, singer, and record distributor who contributed to the development of the ska, rocksteady and reggae genres. He died Saturday morning. He was 87 years old.
Lorna Goodison wins 2026 Derek Walcott Prize for Poetry
Celebrated Jamaican poet Lorna Goodison has added another prestigious international honour to an already distinguished literary career, winning the 2026 Derek Walcott Prize for Poetry for her ground-breaking new translation of the 14th-century classic, Dante’s Inferno. Goodison, Jamaica’s first female Poet Laureate, serving from 2017 to 2020, receives the US$2,000 prize for a work that boldly transports Dante’s epic journey into a Caribbean landscape, drawing deeply on Jamaican language, culture, history and identity.
How to Manage Symptoms of Heart Failure
(Feature Impact) Americans are facing a growing health challenge, with 1 in 4 adults at risk of heart failure, according to the Heart Failure Society of America. Additionally, approximately 6.7 million U.S. adults who are 20 years old or older are currently living with heart failure, and that number is projected to reach 8.7 million by 2030. googletag.cmd.push(function() { googletag.display('JGFI_Article_300x250'); }); Managing heart failure is a significant expense to the U.S. healthcare system, costing the nation approximately $40 billion in 2020 and expected to increase to approximately $142 billion a year by 2050.If you (or a loved one) are living with the condition, consider these tips to help manage it.Adhere to the Treatment and Follow-Up PlanOngoing outpatient care is important when managing heart failure. Understand the treatment plan provided by your healthcare team, make diet and lifestyle changes, take medications as directed and keep recommended follow-up appointments.Pay attention to changes in symptoms and communicate with your healthcare provider if treatment does not seem to be working as expected. If their conditions are left unmanaged, patients can experience a range of heart-failure-related symptoms such as shortness of breath, fatigue, buildup of fluid and more.Understand Challenges with Diuretic TreatmentDiuretics help the body remove excess fluid and are commonly used to treat swelling, or edema, associated with heart failure. Your provider may try different diuretics, sometimes referred to as “water pills,” to manage your heart failure symptoms. However, intravenous (IV) diuretic therapy may be required for some patients if symptoms continue.Ask About Treatment Options Before IV Care Is NeededFor some adults, a healthcare provider may consider recommending an at-home, non-oral diuretic option prior to escalating to IV therapy.For example, ENBUMYST™ (bumetanide nasal spray) is a prescription diuretic used in adults to treat edema associated with congestive heart failure. It’s administered as a nasal spray for short-term use to manage excess fluid with the goal of transitioning to oral diuretic therapy when appropriate.Talk with your healthcare provider to learn more and visit enbumyst.com. Read the full Prescribing Information and Patient Information.Photo courtesy of Shutterstock googletag.cmd.push(function() { googletag.display('JGFI_Article2_300x250'); }); Important Safety InformationWhat is ENBUMYST?ENBUMYST is a prescription medicine used in adults to treat swelling caused by excess fluid in the body (edema) from congestive heart failure, liver disease, and kidney disease.What is the most important information I should know about ENBUMYST?ENBUMYST is a diuretic that helps your body remove fluid. Losing too much fluid can cause dehydration, low blood volume, and increase the risk of blood clots. Blood abnormalities may include decreased salts (electrolytes), and increased nitrogen, glucose and uric acid. The risk of these abnormalities is higher in elderly people, those using higher doses, or those who do not get enough electrolytes by mouth.You should not use ENBUMYST if you have severe electrolyte loss. Tell your healthcare provider if you experience unusual thirst; dizziness or lightheadedness; weakness or tiredness; fast heart rate; dry mouth or tongue; sudden pain; redness or swelling in your joints; pain, swelling, redness, or warmth in your leg; shortness of breath or fast breathing; high blood sugar; dark urine; pale, tight, cool or clammy skin; muscle cramps; confusion.Do not use ENBUMYST if you have low or no urine production or are allergic to bumetanide or to any of the ingredients in ENBUMYST.Before using ENBUMYST, tell your healthcare provider if you have low electrolytes, are on a low-salt diet, have diarrhea, diabetes, nasal problems such as a runny or stuffy nose or polyps, a history of nasal injury or surgery, are or plan to become pregnant, are or plan to breastfeed.Tell your healthcare provider about all the medicines you take, including prescriptions, over-the-counter medicines, vitamins, and herbal supplements.ENBUMYST may cause serious side effects, such as worsening kidney function and ringing in the ears or hearing loss.The most common side effects of ENBUMYST include dehydration, headache, muscle cramps, dizziness, low blood pressure, nausea, and abnormal brain functioning with certain liver problems.These are not all the possible side effects of ENBUMYST. Talk to your healthcare provider for more information.Call your healthcare provider for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.US-ENBU-2600110 googletag.cmd.push(function() { googletag.display('JGFI_Article3_300x250'); });
Free walk-in vaccinations return to Yale Health as flu season looms
More than 3,600 flu and COVID-19 vaccine doses have been administered to Yale students this fall, as Yale Health continues its annual vaccination campaign ahead of the winter respiratory illness season.
How Lula beat Bolsonaro, broke records and halted the right-wing wave aligning Latin America with Trump in 20 days
Luiz Inácio Lula da Silva made history on Sunday, setting a record for Brazil and the rest of Latin America by becoming the first president to win a fourth term – and he did so days before turning 81, an age when many other leaders decide to leave politics behind.
Who are the scariest Arizona Diamondbacks players in history?
PHOENIX — With Halloween around the corner, some of the Arizona Diamondbacks’ scariest figures aren’t in haunted houses, but on the diamond. Throughout their history, several players have struck fear into opponents through overpowering performances, intimidating appearances and unforgettable moments.
Earnings to watch: Caesars Entertainment (CZR) reports Q3 results tomorrow
Hotel and casino entertainment company Caesars Entertainment (NASDAQ:CZR) will be reporting earnings this Tuesday after market close. Here’s what to expect. ...
Earnings to watch: Caesars Entertainment (CZR) reports Q3 results tomorrow
Hotel and casino entertainment company Caesars Entertainment NASDAQ:CZRwill be reporting earnings this Tuesday after market close. Here’s what to expect.Caesars Entertainment beat analysts’ revenue expectations last quarter, reporting revenues of $2.99 billion, up 3% year on year. It was a softer q…
Antelope Island bison roundup brings together family tradition and herd health
Hundreds of riders took part in Saturday's annual bison roundup at Antelope Island State Park, helping move the animals into corrals. The tradition helps with herd health.
Tibetan river hosting world’s biggest dam is facing increasing flood risk: study
Researchers create a hydrological history using tree rings and data to project future run-off and flood risk in the Yarlung Tsangpo River.
World-First Cancer Vaccine Cuts Melanoma Recurrence or Death Risk by 42% in Landmark Trial
"This has not been achieved before in the history of cancer drug development."
Vandalia Health recognized for digital health achievement
Vandalia Health earned Level 9 recognition in both acute and ambulatory care in the 2026 Digital Health Most Wired Survey.
Corpus Christi Museum of Science and History turns Halloween into a hands-on learning experience for kids
The Corpus Christi Museum of Science and History made Halloween educational with hands-on activities, experts and a Mad Science Show.
IN GOOD HEALTH: Preparing for respiratory illness season
By Leanna Coy, FNP-BC As temperatures begin to cool and the holiday season gets underway with Halloween this month, it’s time to prepare for fall and winter respiratory illnesses. As we…
Lions QB Jared Goff Ties NFL History Against Rival Packers
The Detroit Lions are back in action on Sunday afternoon at Ford Field against the divisional rival Green Bay Packers in a clash that will carry heavy implications for the NFC North standings. And thanks to yet another strong start from quarterback Jared Goff, he’s not only put his club in a position to pick […] The post Lions QB Jared Goff Ties NFL History Against Rival Packers appeared first on HEAVY.
Peyton Manning’s Role in Colts GM Search Clarified After Chris Ballard Firing
Peyton Manning is one of the greatest players, if not the greatest, to ever play for the Indianapolis Colts. The former quarterback is one of the most decorated players in American football history. He has won the Super Bowl two times, and is a five-time NFL Most Valuable Player. The Colts have not found the […] The post Peyton Manning’s Role in Colts GM Search Clarified After Chris Ballard Firing appeared first on Gridiron Heroics.
Gauging Global Access to Dermatology Care: Q&A With Esther E. Freeman, MD
Dermatologist and epidemiologist Esther E. Freeman discusses the Global Access to Skin Health Observatory Study and how its findings will hopefully help improve dermatology care worldwide.
"Tomb Raider: Legacy of Atlantis" 30th Anniversary Trailer
A new trailer is out for “Tomb Raider: Legacy of Atlantis,” the reimagining of the original 1996 first “Tomb Raider” game. Created in Unreal Engine 5, it offers fresh visuals, skill trees, and an expanded Atlantis story that will tie in the various eras of Lara Croft together. As Lara, harness your wits and athleticism […]
Elon Musk’s Grok Imagine Releases First Odyssey Episode With Wonder Studios
8 sources compared: Other (4), Western Mainstream (3), Latin American (1). Elon Musk’s Grok Imagine released the first episode of its AI-generated series “The Odyssey,” posting a seven-minute vid...
“Odegaard was outstanding” but Merson was less complimentary about Gyökeres
Paul Merson has delivered contrasting verdicts on two Arsenal players following Saturday’s comfortable 2-0 victory over Everton, singling out Martin Ødegaard for praise while questioning Viktor Gy�...
Sports equinox 2026: Date, schedule, meaning and history behind the rare event
The 33rd sports equinox will occur in 2026.
Absent Vinícius Jr. ‘laughs’ at Barcelona after Real Madrid victory
Real Madrid star Vinícius Jr. has on Sunday evening taken to social media, to issue his response to his side’s victory over arch rivals Barcelona.José Mourinho’s troops made the trip to the Spo...
Bengals Shut out in Disastrous First Half vs Ravens
The Cincinnati Bengals are off to a first half they’d like to forget. Cincy trails the Baltimore Ravens 13-0 in Baltimore.The story has been the Cincinnati Bengals’ defense which has been struggling against this Ravens offense.The Ravens got off to a hot start as Zay Flowers took a 48-yard pass to the house from backup […] The post Bengals Shut out in Disastrous First Half vs Ravens appeared first on HEAVY.
Novant Health hosting Hilton Head hiring event Oct. 28
Novant Health will host a healthcare hiring event Oct. 28 on Hilton Head Island for nursing, laboratory, pharmacy and other positions.
Here's how Bengals' second half vs Ravens made NFL history
The Cincinnati Bengals became just the 10th team in NFL history to get shut out in the first half and then score 35 points or more in the second half.
Here's how Bengals' second half vs Ravens made NFL history
The Cincinnati Bengals became just the 10th team in NFL history to get shut out in the first half and then score 35 points or more in the second half.
Remembering Freddie Freeman’s Iconic Walk-Off Grand Slam
Los Angeles Dodgers first baseman Freddie Freeman hit one of the most important home runs in Dodgers history two years ago, today.
Why Democrats see a path to victory in Mississippi midterm election
Cleveland Browns rookie WR hits historic mark against Titans
KC Concepcion’s 129 receiving yards places him in the Top 10 for a single game by a rookie in franchise history.
Primark's Business Doesn't Make Sense
In a world where fast fashion giants like Shein, Zara, and H&M drop thousands of new styles every day — and rake in billions through e-commerce — Primark is doing the unthinkable: thriving with zero online shopping. So what gives?*Want to Know the 5 Trends Changing Modern Retail? Find Out Here:* 🔗 https://clickhubspot.com/d13ac2In this video, we take you inside Primark’s weirdly brilliant business model — a model that’s stuck in the past on purpose. From warehouse optimization and floor-ready freight shipments to why the pandemic didn’t push them online, we unpack how this low-cost retail giant has managed to defy digital norms… and make it work.This isn’t just about one brand. It’s a story about modern retail expectations — and what it actually takes to meet (or reject) them.Subscribe to The Hustle:🔗 https://clickhubspot.com/vu3lGet the 5-minute newsletter keeping 2M+ innovators in the loop🔗 https://clickhubspot.com/3klnAbout HubSpot: HubSpot is a customer platform that provides education, software, and support to help businesses grow better. The platform includes marketing, sales, service, commerce, operations, and website management products that start free and scale to meet our customers’ needs at any stage of growth. Today, thousands of customers around the world use HubSpot’s powerful and easy-to-use tools and apps to attract, engage, and delight customers.#TheHustle #HubSpot
Utah business, government leaders deepen connections in Ireland
Utah Gov. Spencer Cox met with Irish Prime Minister Micheál Martin on Wednesday amid a trade mission organized by World Trade Center Utah.
Why is the U.S. accusing Canada of election interference?
the U.S. Embassy accused Canadian officials of meeting with Democratic lawmakers, urging the use of retaliatory levies to hit Republican states, and running anti-tariff political advertising.
The Future of IBD Treatment: 4 Promising Therapies to Know About
New treatments are in development for inflammatory bowel diseases like Crohn’s disease and ulcerative colitis. Find out what experts say you should know.
Uganda tightens Ebola border controls and requires returnees from Congo to pay for quarantine
Uganda is reinforcing existing border controls requiring citizens returning from Congo to undergo 21 days of quarantine at their own expense, the Health Ministry said Sunday, as investigators examine how a woman who traveled from Uganda to Nigeria cont...
'You Can See Everything' surges with $19.5M at box office; 'Clayface' takes No. 1
DC Studios scored a modest, R-rated win with “Clayface,” landing a $24 million opening weekend, according to studio estimates Sunday. But the biggest success story in theaters remained A24’s...
'You Can See Everything' Surges With $19.5M at Box Office; 'Clayface' Takes No. 1
NEW YORK (AP) — DC Studios scored a modest, R-rated win with “Clayface,” landing a $24 million opening weekend, according to studio estimates Sunday. But the biggest success story in theaters remained A24’s Elizabeth Holmes documentary “You Can See Everything,” which pulled in $19.5 million in its ...
Argentina Folk Sounds, Controversy: Milo J, Cazzu, Broke Carey
Milo J, Cazzu, and more stars are embracing music and traditions of the Argentine countryside and sharing their history with the world.
How Argentina’s Folk Sounds Are Shaping a Generation’s Politics and National Pride
Milo J, Cazzu, and more stars are embracing music and traditions of the Argentine countryside, staving off pop homogenization and sharing their history with the world
Liverpool 2, Brighton 0 – Match Recap: That Was Actually Fun
A look back at the key moments in Liverpool's great victory over Brighton in Premier League action.
ESMO: Roche touts ‘convincing’ phase 3 KRAS data after win over rivals
Roche has shed more light on its investigational KRAS G12C inhibitor's phase 3 victory over Amgen’s Lumakras and Bristol Myers Squibb’s Krazati. The open-label Krascendo 1 trial enrolled 338 people with previously treated KRAS G12C-mutated non-small cell lung cancer (NSCLC). Patients who had already received a KRAS G12C inhibitor or pan-KRAS/RAS inhibitor were excluded from the trial. Participants received either divarasib once daily, Lumakras once daily or Krazati twice daily. Roche announced back in July that divarasib had demonstrated statistically significant improvements in progression-free survival (PFS) and overall survival (OS), meeting the trial’s primary and key secondary endpoints. But the Swiss pharma had been holding back the detailed data until now. At the European Society for Medical Oncology (ESMO) Congress in Madrid, Roche revealed that median OS for the 167 patients who received divarasib was 17.7 months, compared to 12 months for the 171 patients who received Lumakras or Krazati. The benefit was similarly clear when it came to median PFS, which stood at 9.8 months versus 5.7 months, respectively. A total of 44% of patients receiving divarasib were alive without disease progression at one year, compared to 24% of the control group, according to Roche’s presentation. It was a similar story for the objective response rate, which came in at 58% for divarasib versus 32% for the control group, while median duration of response was 11.9 months versus 6.9 months. Stefan Frings, M.D., Ph.D., deputy chief medical officer at Roche Pharma, told Fierce that the data made for a “very comprehensive, strong package, which should be convincing to health authorities.” “It’s an important advance for patients with lung cancer,” Frings said in an interview at a Madrid hotel during the conference. “It's a second-line setting, and patients who receive divarasib benefit compared to the current first-generation KRAS G12C inhibitors by having far longer overall survival,” he continued. “They live longer. They have better progression-free survival, better response rates, and with a safety profile which is—if [anything]—even better,” he said. According to Roche, 4.8% of patients receiving divarasib discontinued treatment due to treatment-related adverse events, compared to 11.7% in the control group. Serious treatment-related adverse events were also less common with divarasib, at 7.8% versus 15.2%. Roche’s confidence in divarasib had been building even before this phase 3 success. The candidate had already shown better potency and selectivity than the incumbent KRAS G12C inhibitors Krazati and Lumakras in preclinical tests. After cross-trial comparisons suggested that the edge translated into better clinical outcomes, Roche axed a study comparing divarasib to the chemotherapy docetaxel and went toe-to-toe with Lumakras and Krazati. “We designed the drug on purpose with higher potency and better selectivity,” Frings explained. “So, based on preclinical models, we clearly knew it would be superior to the first generation.” “It’s honestly not so frequent that pharma companies go head-to-head,” he added. “But if you want to make a point, if you want to convince payers, prescribers and patients … then a head-to-head win is rather rewarding.” While Amgen and BMS reached the regulatory finish line first for KRAS G12C-mutated, locally advanced or metastatic NSCLC in 2021 and 2022, respectively, they have struggled to capitalize on their head start. Krazati brought in $55 million for BMS in the second quarter, while Lumakras delivered $111 million to Amgen. For its part, Roche is aiming for peak divarasib sales of 1 billion to 2 billion Swiss francs ($1.2 billion to $2.5 billion), according to Frings. The Big Pharma is currently recruiting patients into a phase 3 trial comparing divarasib plus Keytruda against Keytruda plus chemotherapy in previously untreated advanced or metastatic nonsquamous KRAS G12C-mutated NSCLC. Roche has previously suggested that sales in metastatic disease would account for most of the forecast. Frings was tight-lipped on the exact timeline for a regulatory filing but said the Swiss pharma is “certainly keen to get this to as many patients as possible around the world.” Roche has more RAS drugs coming up behind divarasib. The pharma has already launched phase 1 trials of a pan-RAS inhibitor called RG6505 and a KRAS G12D inhibitor dubbed RG6620 in solid tumors. Roche’s partner Chugai Pharmaceutical is also testing a pan-KRAS inhibitor called AUBE00. Roche has made a “deliberate effort” to test a range of RAS drugs, Frings said. “If you have many rare mutations and you are scrambling to find sufficient patients, a pan-RAS inhibitor makes a lot of sense,” he explained.
World's Fastest Lawnmower Company Is Officially Going Out Of Business
Dixie Chopper made the world's raddest lawnmowers for almost half a century, but its story is now coming to an end.
Jayson Tatum Reacts to Encouraging Celtics Development Against Knicks
The Boston Celtics beat the New York Knicks 107-103 on Friday night at TD Garden. Jayson Tatum scored 36 points and closed the game with a run that sealed the win. The stat line told the obvious story.But after the game, the moment Tatum wanted to talk about was not one of his own. It […] The post Jayson Tatum Reacts to Encouraging Celtics Development Against Knicks appeared first on HEAVY.
Michigan's Jason Beck promised change, but numbers tell another story
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Memorial Health dietitian highlights importance of blood sugar management
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Bill Gates sees 20 years of turmoil before AI creates 'true abundance'
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Union to Dedicate Historic Marker Commemorating Battle of Connecticut Farms as Part of America's 250th Celebrations
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Mateer Manages Himself and Mississippi State in Win
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Economic woes transform the Midwest into a massive midterms battleground
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FAU star receiver achieves historic feat with 5-TD performance
The FAU Owls set themselves apart in college football history following a spectacular performance from Easton Messer in their 51-49 win over the Rice Owls on Saturday afternoon. Messer is going through the final season of his collegiate career, his second with the Owls. He shines as one of the best receivers in the nation, ranking high with a lot […] The post FAU star receiver achieves historic feat with 5-TD performance appeared first on ClutchPoints.
Bethune-Cookman scores wild upset victory over Jackson State
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Houston Rockets jersey history No. 35 - Larry Spriggs (1981-82)
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Ramaswamy ad puts Acton’s estranged mother in spotlight as records reveal family’s troubled past
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Scientists discover how pancreatic cancer rewrites its DNA to escape treatment
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Finding biomarkers for aggressive prostate cancer
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UCF outlasts No. 2 BYU in 2OT, notches first top-5 win in program history: 'That's the weirdest end of a game I've ever seen'
Scott Frost's Knights came out on top of a doozy.
Skip Bayless Has Bold Vikings Declaration After Bears Win
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Halloween at the Castle offered day of spooky science Saturday
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Nebraska volleyball vs. USC live updates, stats and highlights
Nebraska hosts USC in a Big Ten volleyball match on Saturday night. The Huskers are undefeated through 20 games for the 10th time in program history.