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Discover Long Island revamps website for visitors, locals
Discover Long Island has launched a redesigned website aimed at providing an immersive and user-friendly experience for both visitors and locals. The site incorporates AI-driven features, improved navigation and local storytelling to showcase Suffolk County and regional attractions, with plans to add international translations and itinerary-building tools in the future.
Michael Douglas denies rumor he punched “Basic Instinct” director Paul Verhoeven
The Oscar winner recounts an on-set confrontation the two had over Sharon Stone in his new memoir.
Highlights: Titusvile vs. Sharon high school football
Sharon (4-2) will visit Slippery Rock next week.
BofA battles for talent as business banker hiring surges
Bank of America's Sharon Miller says competitors recognize business owners as a fountain of leads for cross-selling opportunities and are chasing that business, too.
The biggest celebrity guests attending Cincinnati Comic Expo 2026
The 2026 Cincinnati Comic Expo returns Sept. 25-27, with stars like Hayden Christensen, Priscilla Presley and Sharonville-native Carmen Electra.
Mental health at center of Mount Dora double murder trial as defense and prosecution rest
Vicki Williams declined to testify in her own defense Monday as attorneys rested their case in the double murder trial involving the deaths of Darryl and Sharon Getman.
‘Youth’ Creator Sharon Horgan Explains the Premiere’s Emotional Rug-Pull Ending
"Youth" creator Sharon Horgan tells TheWrap about writing her new mother-son coming-of-age story and unpacks the HBO comedy's premiere.
'Youth' review: HBO's coming-of-middle-age comedy is messy and moving, as only Sharon Horgan can
Sharon Horgan's latest is a frank look at a 50-year-old woman's search for love.
'Let's get this stadium into the 21st Century'
Sharon: This sounds a very positive thing that will bring Forest forward with them now still being in the Premier League. Can't wait to see what it's going to turn out like - bring on the future for Nottingham Forest! Roger: After the old Main Stand is replaced, Forest should focus on rebuilding the present Bridgford Stand - now renamed in memory of John Robertson.
Sharon Stone shades “Euphoria” costar Sydney Sweeney for her lingerie line
“I tried to get Sydney Sweeney’s character to stop being a cam girl,” the “Casino” star said. “As you can see from Sydney’s new lingerie line, it didn’t take.”
Anaheim Hills briefs: Fall health fair sponsored by Anaheim’s Older Adult Program
Sharon Hlapcich writes about events and happenings in the Anaheim Hills area.
Four rural CT hospitals receive $46 million in federal health grants
Charlotte Hungerford, Day Kimball, Sharon and Windham Hospitals were awarded the funds through U.S. Rural Health Transformation Program.
Sharon Regional Health: Employees to be paid today
Several employees at the Sharon Regional Health System hospital in Sharon reached out to 21 News late last week, claiming that they had not received their paychecks as of Friday
Sharon Stone 'nearly died' after 'Basic Instinct' role, she says
Sharon Stone says "darkness" came into her life after her villainous role in "Basic Instinct."
Meet a Health Hero Finalist: Sharon Pervez-Khan
After her daughter Elora was diagnosed with an incurable, cancerous brain tumor, the Villanova mom made it her mission to accelerate research, funding, and life-saving treatment.
AZ's R&D chief Barr touts internal 'science success story' after IL-33 antibody's stellar showing in COPD
With a detailed data drop that AstraZeneca’s R&D chief described as an internal “science success story,” the British Big Pharma has secured an FDA priority review for what it believes could become a flagship biologic in chronic obstructive pulmonary disease (COPD). In detailed results from the late-stage Oberon and Titania trials—first teased in March and detailed in full at the European Respiratory Society Congress in Barcelona this week—the drugmaker laid out the extent of its IL-33 inhibitor’s potential to reduce moderate and severe exacerbations in a wide range of COPD patients still struggling with those “lung attacks,” as AstraZeneca’s Sharon Barr, Ph.D., called them, despite using standard-care inhaled therapy. In the headline results, a 300 mg dose of tozorakimab given once every four weeks curbed those moderate and severe exacerbations in the studies’ primary population of former smokers by 29% in the Oberon study and 34% in Titania. In the overall population of both current and former smokers, these reductions were 30% and 29%, respectively, versus placebo and inhaled standard of care. The benefits also extended to clinically meaningful exacerbation reductions in all prespecified patient subgroups and specifically turned up promising signals in patients across a range of blood eosinophil counts, with Barr telling Fierce that “it’s the details that make this even more exciting than the high-level results that we’ve already shared.” In fact, during AZ’s tozorakimab poster presentation at the ERS 2026 Congress this past weekend, attendees were so enamored by the data that event organizers had to encourage people to clear the room and look at the other presentations on offer, Barr said in an interview. “I think it really speaks to the fact that there is a lot of buzz around these data because the entire respiratory community has been so desperate for new therapies for these patients,” she explained. The respiratory disease continues to represent a “staggering unmet medical need,” Barr said, highlighting the COPD exacerbations that the Oberon and Titania studies homed in on, which she added carry a greater mortality risk than a heart attack. “When a patient has a severe exacerbation, only about half of them are still alive within three and a half years,” she pointed out. As for tozorakimab specifically, Barr christened the molecule “an AstraZeneca science success story,” harkening several years back to the point at which researchers began to explore IL-33 as a driver of respiratory disease, and COPD in particular. At the same time, “there was still so much that wasn’t understood,” she admitted, highlighting the insight that IL-33 signals through both ST2 and EGFR through the RAGE pathway, a discovery Barr attributed to AstraZeneca's own scientists. Understanding the need to tackle both pathways in COPD—and aware of competitor candidates in the hopper, including one that bound ST2—the company ultimately had to make some “courageous decisions,” Barr said. These included taking a prior COPD molecule offline and going back to the drawing board to reinvent its potential IL-33 label “to make sure that we had a molecule that could block signaling through both arms of the pathway, through both the reduced form and the oxidized form, knowing that we wouldn’t be first, but striving to be best.” “When we put [tozorakimab] into the clinic, we firmly believed that we had a differentiated molecule, and we saw the other molecules blocking just ST2 or partially blocking IL-33, unable to deliver two positive pivotal studies in COPD,” Barr explained. “We kept marching forward because we believed our molecule was differentiated, and now I think we have the clinical validation that supports that.” Ultimately, AstraZeneca finds itself on much better footing these days when it comes to potential biologic rivals to tozorakimab in COPD. Sanofi and Regeneron’s Dupixent, for instance, is approved to treat COPD exacerbations in patients with high eosinophil counts, but not low ones. Meanwhile, the future has become cloudier for other next-gen IL-33 candidates from Sanofi and Regeneron, as well as Roche, which have suffered trial flops in recent years. One other potential ingredient for AstraZeneca’s success in its duo of studies was that the company was “ambitious in the trial design, willing to look at an all-comers population,” Barr said, “and willing to enroll the most severe patients.” Prior studies for would-be biologics rivals in COPD “avoided enrolling” those patients, she pointed out. She also highlighted the Big Pharma’s painstaking design of exacerbations in its trial, which “gave us a very rigorous readout,” and pointed to “the extra effort and investment” the company put in to understand the effect of mucus plugs in patients. Barr described mucus production as a “key feature in disease diversity,” noting that mucus plugs—obstructing clumps of mucus that block patients’ airways—are associated with worse outcomes in COPD. In its data announcement, AstraZeneca noted that an integrated analysis of Oberon and Titania found tozorakimab “demonstrated a reduction in patients’ mucus plug score,” with the pharma claiming its biologic is the first to deliver such results in a broad COPD population. “So being able to reduce those mucus plugs, we expect, is an important part of driving benefit for patients who are living with COPD,” Barr said. Again touching on the breadth of the study populations, Barr added that tozorakimab “worked across all eosinophil levels in both current and former smokers across all levels of lung function,” which she suggested “really simplifies decision-making for clinicians, and it allows them to offer therapy to the broadest possible patient population.” In the highest patient eosinophil count group, tozorakimab helped chart a 43% reduction in exacerbation risk, which Barr stressed were “unprecedented data.” In the mid-level group, AZ’s drug delivered a 23% reduction and, in the lowest group, a 34% reduction in eosinophils, which Barr said suggests efficacy “in all patient subgroups.” As for AZ’s recent guidance upgrade on the medicine’s sales opportunity, the lift from a $3 billion to $5 billion range to $5 billion plus was informed by multiple factors, Barr said, including the fact that “in 2024, there were multiple competitors, and there aren’t anymore.” Additionally, “we know that this is a massive unmet medical need, and this is a really incredible set of data that we think will be very convincing to the clinical community,” Barr said. Looking ahead to a potential evolution of the COPD treatment landscape, Barr noted that most patients start treatment in the community with an option like a triple therapy, and for them, having an option like AstraZeneca’s inhaler Breztri will remain a “really important part” of that journey. But of the patients uncontrolled on triple therapy, which Barr described as “about half of them today,” just a “small fraction” are currently eligible for biologic therapy, which she emphasized AstraZeneca is working to change. Understanding that COPD is not a “one-size-fits-all” disease, AstraZeneca is also looking at its antibody drug Tezspire for patients with T2-driven disease, and the company continues to think about new mechanisms for tackling COPD through both systemic and inhaled drugs, Barr said.
Sharon Stone details what she saw following terrifying near-death experience
Sharon Stone recalled seeing orbs that gave her a premonition about the custody battle over her son, following her 2001 stroke.
University Place to become ‘entertainment district,’ allow alcohol on property
As University Place in Chapel Hill continues its redevelopment, the mall is preparing to launch an “entertainment district” that will allow customers to order alcoholic drinks to go and walk around the property. An entertainment district is a state-governed drinking area, whereas a social district is created by a local government with an ordinance, Aaron...
University Place to become ‘entertainment district’, allow alcohol on property
As University Place in Chapel Hill continues its redevelopment, the mall is preparing to launch an “entertainment district” that will allow customers to order alcoholic drinks to go and walk around the property. An entertainment district is a state-governed drinking area, whereas a social district is created by a local government with an ordinance, Aaron...
The Bulletin welcomes Sharon Weinberger as editor-in-chief
The Bulletin’s new editor-in-chief, Sharon Weinberger, has dedicated her career to covering the intersection of science, technology, and national security and will guide the Bulletin’s editorial efforts as it enters its eighth decade of informing the public on catastrophic risks.
How Medicaid fraud could affect your tax dollars and health care
Local 12 WKRC-TV is the local station for breaking news, weather forecasts, traffic alerts, community news, Cincinnati Bengals, Reds and FC Cincinnati sports updates, and CBS programming for the Cincinnati , Ohio area, including Avondale, Blue Ash, Bond Hill, Camp Washington, Cheviot, Cleves, Colerain Township, Columbia-Tusculum, Corryville, Norwood, Delhi, East Price Hill, Golf Manor, Hyde Park, Lebanon, Loveland, Lower Price Hill, Madeira, Mariemont, Mount Adams, Mount Airy, Mount Healthy, Mount Lookout, Mount Washington, Oakley, Over-The-Rhine, Reading, Sedamsville, Sharonville, Springdale, St. Bernard, South Cumminsville, Symmes Township, Mason, Hamilton, Union Township, Walnut Hills, West Chester, Wyoming, West Price Hill, Westwood, Winton Hills, Alexandria, Bellevue, Covington, Crescent Springs, Erlanger, Fort Mitchell, Fort Thomas, Fort Wright, Florence, Hebron, Highland Heights, Newport, Southgate, Villa Hills, Walton, Aurora, Greendale, and Lawrenceburg.
Owners of West Side restaurant and entertainment spot announce plans to sell
Local 12 WKRC-TV is the local station for breaking news, weather forecasts, traffic alerts, community news, Cincinnati Bengals, Reds and FC Cincinnati sports updates, and CBS programming for the Cincinnati , Ohio area, including Avondale, Blue Ash, Bond Hill, Camp Washington, Cheviot, Cleves, Colerain Township, Columbia-Tusculum, Corryville, Norwood, Delhi, East Price Hill, Golf Manor, Hyde Park, Lebanon, Loveland, Lower Price Hill, Madeira, Mariemont, Mount Adams, Mount Airy, Mount Healthy, Mount Lookout, Mount Washington, Oakley, Over-The-Rhine, Reading, Sedamsville, Sharonville, Springdale, St. Bernard, South Cumminsville, Symmes Township, Mason, Hamilton, Union Township, Walnut Hills, West Chester, Wyoming, West Price Hill, Westwood, Winton Hills, Alexandria, Bellevue, Covington, Crescent Springs, Erlanger, Fort Mitchell, Fort Thomas, Fort Wright, Florence, Hebron, Highland Heights, Newport, Southgate, Villa Hills, Walton, Aurora, Greendale, and Lawrenceburg.
Mercy Health expands maternity care by connecting patients with midwives
Local 12 WKRC-TV is the local station for breaking news, weather forecasts, traffic alerts, community news, Cincinnati Bengals, Reds and FC Cincinnati sports updates, and CBS programming for the Cincinnati , Ohio area, including Avondale, Blue Ash, Bond Hill, Camp Washington, Cheviot, Cleves, Colerain Township, Columbia-Tusculum, Corryville, Norwood, Delhi, East Price Hill, Golf Manor, Hyde Park, Lebanon, Loveland, Lower Price Hill, Madeira, Mariemont, Mount Adams, Mount Airy, Mount Healthy, Mount Lookout, Mount Washington, Oakley, Over-The-Rhine, Reading, Sedamsville, Sharonville, Springdale, St. Bernard, South Cumminsville, Symmes Township, Mason, Hamilton, Union Township, Walnut Hills, West Chester, Wyoming, West Price Hill, Westwood, Winton Hills, Alexandria, Bellevue, Covington, Crescent Springs, Erlanger, Fort Mitchell, Fort Thomas, Fort Wright, Florence, Hebron, Highland Heights, Newport, Southgate, Villa Hills, Walton, Aurora, Greendale, and Lawrenceburg.
Small business spotlight: Lockwood Cafe
In the Ontario neighborhood of Ames is Lockwood Cafe. Opened in 2017 by Sharon Stewart, the cafe serves as a community-first space. This is reflected in the businesses around it, its connections to other businesses in Ames, and its patrons. Stewart shared how the business started and how its neighborhood is vital to the cafe’s...
A family dinner led two Israeli scientists to a clue about life’s origins
A joint study by Prof. Michal Sharon of the Weizmann Institute and her brother Prof. Yossi Paltiel of the Hebrew University suggests magnetism may have influenced two chemical 'fingerprints' of life: molecular chirality and isotope ratios
Wisconsin STEM shuttle program marks 20 years of taking science on the road
The STEM Shuttle, created by retired Wausau teacher Sharon Ryan, is marking its 20th year traveling to schools across Wisconsin. The program grew out of Dream Flight Wausau, a 1990 project Ryan developed while teaching at John Marshall Elementary School in the Wausau School District.
5 foods for heart health you can actually eat every day
Discover which foods you can eat to best support a healthy heart over time, according to research
What’s being built, bought and planned in Ascension Parish
Here are the latest property transactions, issued permits and upcoming business-related events in Ascension Parish. Property transactions Local organization American Soldiers Evaluation Services purchased a 4,000-square-foot office building on East Josephine Street from Nolan and Sharon Aikens for $400,000. American Soldiers Evaluation Services’ CEO, Dr. Sandrine Nkouga, represented the buyer in the transaction. ASES provides […]
Sharonville mom raising money for UC Health's ICU patient program after she nearly died
It's been a year since a Sharonville mom suffered a medical emergency days after giving birth to her second child.
After 207 years, Cincinnati's oldest business moving to historic Tri-State mansion
Bromwell's Fireplace Specialists, founded in 1819, announced plans to relocate from downtown Cincinnati to the historic Hauck summer home in Sharonville.
Sharon O'Keefe
As president of the University of Chicago Medical Center and chief operating officer of the 1,286-bed University of Chicago Medicine health system, Sharon O’Keefe oversees a clinical enterprise with annual operating revenue of $2.21 billion. In the past 18 months, UChicago Medicine opened an expanded adult emergency department—a $39 million investment—and an adult trauma center. Since 2011, the system has generated annual growth of nearly 5 percent in revenue and 4 percent in patient admissions. O’Keefe previously was president of Loyola University Medical Center and executive vice president and chief operating officer at Boston’s Beth Israel Deaconess Medical Center. She serves on the Illinois Hospital Association finance and audit committee and is on the American Heart Association’s Midwest affiliate board.
Jack and Sharon Osbourne comment on plans for AI Ozzy
She said that creating the Ozzy avatar was about keeping up with the times and evolving technology, in addition to keeping the singer’s legacy alive.
Several vehicles damaged as fire spreads to Tri-State business
Local 12 WKRC-TV is the local station for breaking news, weather forecasts, traffic alerts, community news, Cincinnati Bengals, Reds and FC Cincinnati sports updates, and CBS programming for the Cincinnati , Ohio area, including Avondale, Blue Ash, Bond Hill, Camp Washington, Cheviot, Cleves, Colerain Township, Columbia-Tusculum, Corryville, Norwood, Delhi, East Price Hill, Golf Manor, Hyde Park, Lebanon, Loveland, Lower Price Hill, Madeira, Mariemont, Mount Adams, Mount Airy, Mount Healthy, Mount Lookout, Mount Washington, Oakley, Over-The-Rhine, Reading, Sedamsville, Sharonville, Springdale, St. Bernard, South Cumminsville, Symmes Township, Mason, Hamilton, Union Township, Walnut Hills, West Chester, Wyoming, West Price Hill, Westwood, Winton Hills, Alexandria, Bellevue, Covington, Crescent Springs, Erlanger, Fort Mitchell, Fort Thomas, Fort Wright, Florence, Hebron, Highland Heights, Newport, Southgate, Villa Hills, Walton, Aurora, Greendale, and Lawrenceburg.
Bayonne Mayor-Elect Nadrowski Selects Andrew Casais as Business Administrator
Mayor-Elect Sharon Nadrowski today announced her selection of Andrew J. Casais as the next Business Administrator for the City of Bayonne. Casais brings more than 15 years of municipal management experience, including nearly three years as Bayonne’s Chief of Staff from 2014 to 2017. During his career, he has championed major infrastructure investments, operational reforms,[...]
Sharon Stone knew her marriage was 'over' when husband questioned her getting mastectomy despite massive tumor
Actress Sharon Stone said she knew her marriage was finished when her then-husband was 'furious' with her decision to get a double mastectomy after doctors found tumors in her breasts: 'He was done with me then.'
State budget delivering $30 million in aid to Syracuse
The city of Syracuse will receive a total of $30 million in additional aid through the 2026-27 state budget, officials said.
Globavend Welcomes Pictureworks CEO to Lead Its AI-Driven Entertainment Business
PERTH, Australia, May 19, 2026 (GLOBE NEWSWIRE) -- via IBN -- Globavend Holdings Limited (NASDAQ: GVH) (“Globavend” or the “Company”), an emerging e-commerce logistics provider and digital entertainment company, today announced the appointment of Fuk Yan Tse, known as Sharon Tse (“Ms. Tse” or “Sharon”), as Chief Executive Officer of Loomi Group, the operating arm of the Company’s digital entertainment business. This newly created position follows the Company’s transformational move into the digi
Boston City Council ‘mean girl politics’ accusations fly amid $4.9B budget cuts battle
Boston City Councilor Erin Murphy decried “mean girl politics” after her latest late file order was blocked again by Councilor Sharon Durkan, this time delaying a hearing on ways to restore firefighter cancer screening funds.
Why we need to talk more about menopause and its health consequences
More than 1 million women in the U.S. start menopause every year, yet this biological certainty is too often shrouded in secrecy or ignored by many mainstream researchers. Horizons moderator William Brangham explores what we do and don’t know about menopause with Dr. Sharon Malone and Dr. Lauren Streicher.
College Where Charlie Kirk Was Killed Cancels Speech
Utah Valley University was thrilled that Sharon McMahon, a best-selling author, would speak at its graduation. And then her old posts resurfaced.
Sharon Tucker Named Orlando Health Endowed Chair in Nursing
The prestigious appointment from the UCF Pegasus Partner will bolster Tucker’s nationally recognized research focused on helping practitioners and patients thrive.
Boston Marathon 2026: Kenya's John Korir, Sharon Lokedi each win men's and women's races for 2nd consecutive year
Boston Marathon 2026: Kenya's John Korir, Sharon Lokedi both win men's and women's races for 2nd consecutive year
Boston Marathon 2026: Kenya's John Korir, Sharon Lokedi both win race for 2nd consecutive year
2 of 5 sentenced in local $2M health care fraud scheme
Two of five men convicted in a $2 milion health care fraud scheme in Sharon were sentenced this week in federal court.
Centrepoint to cut ties with Sharon Osbourne after she backs Tommy Robinson rally
Homelessness charity distances itself after Osbourne says she plans to attend far-right ‘unite the kingdom’ march
Note to Colorado lawmakers — parents protecting kids isn’t abuse, it’s their job
By Matt Sharp and Sharon Supp During the last few years, the U.S. Supreme Court has made at least one thing clear: Colorado is consistently overreaching to apply its laws in unconstitutional ways. Colorado treated a cake artist with hostility because of his religious beliefs in Masterpiece Cakeshop v. Colorado Civil Rights Commission. The state […]
Sharon Stone Reveals Surprising Actor as ‘Best Kisser in the Business’
Stone admitted that the A-list actor 'knocked me out' with his smooching skills.
Bank of America courts business clients in market-share push
To drive new client relationships in 50-some markets, BofA is hiring bankers and cultivating local connections, said Sharon Miller, the lender’s president of business banking.
Sharon Osbourne tells Hollywood elites to save politics 'for your platform' when accepting awards
Sharon Osbourne criticizes artists giving political speeches at award shows, saying viewers need "relief" from world events on "The Osbournes Podcast."
Joy Behar says 'God canceled' the 'View' rival series 'The Talk' as Sheryl Underwood reacts to feud
Joy Behar said 'God canceled' the 'View' rival series 'The Talk' as guest cohost Sheryl Underwood addresses her feud with Sharon Osbourne: 'When she's hurt, she's really hurt.'
Five to Try: Sports Bars
WATCH HOOPS, MUNCH, AND HOPE FOR MARCH GLADNESS By Butch Maier / Photo above: Socky's co-owners Sharon Sockman, David Sockman, and Alison Sockman-Gilli ...
Teen shot outside of Sharonville business, police say
The teen was taken to the hospital for non-life-threatening injuries
Syracuse mayor to deliver her first State of the City address
Mayor Sharon Owens' speech will begin at Nottingham High School at 6 p.m.
Sharon Regional, Independence Health System partner to expand cardiovascular care
The release states patients will benefit from enhanced clinical capabilities, expanded specialty services, and better access to cardiologists and cardiovascular surgeons.
Why small, medium businesses are 'cautiously optimistic' about 2026
Small and medium-sized business owners are remaining cautiously optimistic in their 2026 outlook, according to Bank of America's latest Business Owner Report, as they continue to contend with inflation and even tariff pressures. Bank of America President of Business Banking Sharon Miller shares the findings from the survey, noting how 70% of these surveyed businesses plan to expand this year. To watch more expert insights and analysis on the latest market action, check out more Morning Brief.
UNC Charlotte Chancellor Sharon L. Gaber named Business Person of the Year for 2025 by Charlotte Business Journal
UNC Charlotte had a banner year in 2025, and the region is taking notice. Charlotte Business Journal named Chancellor Sharon L. Gaber Business Person of the Year for 2025, recognizing her innovative leadership in growing the University’s national profile, expanding its presence in uptown and solidifying it as an economic driver for the region. In […]
Art and entertainment in 2025
In 2025, the pages of Compass tracked the steady hum of creativity across the Northwest Corner. Here’s a look at some of the highlights that shaped the year.ARTThe Hotchkiss School marked 50 years of co-education with The Art of Joy Brown, a sweeping retrospective honoring the internationally celebr...
I left my Hollywood stunt career for 15 months to travel to 35 countries. I came back ready to plan my future beyond LA.
Sharonda Scott, now 37, set a rule not to spend more than $500 per plane ticket during her 15 months of travel.
Sharon Osbourne says Ozzy's infidelity didn't faze her until he brought another woman into their home
Sharon Osbourne was both aware of and largely unbothered by the indiscretions of her late husband, Ozzy Osbourne — with one notable exception.
TheWrap Wins Best Website at 18th Annual National Arts & Entertainment Journalism Awards
TheWrap won Best Website on Sunday at the Los Angeles Press Club's 18th annual NAEJ Awards, winning eight awards in total.