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OpenAI announces 3 AI-generated discoveries in mathematics, computer science, physics
ChatGPT developer says AI models produced proofs addressing longstanding scientific problems, seeks independent academic scrutiny | Anadolu
How Sports Betting Is Becoming Part of the Luxury Entertainment Experience
Sports fans spend their money on more than a ticket now. They pay for private entrances and better seats. They pay for hospitality that begins before the game and continues after. PwC surveyed 1,000 high-net-worth sports fans in the United States and found 60% would spend more than $250 on a premium event and one […]
Opinion: Chicago’s push to protect gig workers threatens their independence
Chicago's delivery rules risk gig worker flexibility. States should offer portable benefits, argues an Americans for a Modern Economy adviser.
Apple Creator Studio gets powerful new AI features using OpenAI models
Apple Creator Studio updates have today been announced, with what the company describes as “powerful new AI features” using a...
Opera introduces a new web standard to let users deploy AI locally in their browser
The new standard, WebAI, is designed to work with a variety of AI models.
Ex-DOGE startup's AI agents broke into Anthropic's business systems in less than 12 hours
Anthropic says the researchers reached a limited set of sales, HR and IT systems but not Claude conversations, source code or model weights
OpenAI asks outside experts, including a Nobel laureate, to check proofs its AI produced in math, computer science, and physics
OpenAI says its internal AI models have cracked three major open questions in math, computer science, and physics. One of them is part of a famous Millennium Prize Problem, each of which carries a $1 million prize. Outside experts, including a Nobel laureate, are now checking whether the proofs hold up. If the computer science proof holds on its own, hundreds of research papers lose their foundation.
Modern warehouses test limits of fire protection
Modern warehouses — some up to 100 feet high and spanning hundreds of thousands of square feet — are straining existing fire protection systems as automated storage and increasingly combustible goods…
Machine learning models predict common cancer risks using routine health data
Machine learning models using routinely collected health information, such as blood tests, medical history and lifestyle factors, could help identify people at higher risk of several common cancers, according to an international study reported at the ESMO Congress 2026.
iPhone 18e Could Get Two Key Upgrades While Keeping 60Hz Display
Apple's upcoming iPhone 18e model will retain a 60Hz display but could gain an upgraded front-facing camera, according to the leaker known as "Digital Chat Station". In a new post on Weibo, the leaker said that the device will feature a 6.12-inch OLED display using low-temperature polycrystalline silicon (LTPS) technology, the A20 chip, and a single 48-megapixel rear camera. They were less definitive about the front-facing camera, saying it could be upgraded to 24 megapixels.
Giving quantum computers a way to pick up where they left off
FIU is researching how to restart quantum workflows after interruptions to preserve computational progress. It lays the groundwork for quantum machine learning for drug discovery and climate modeling.
Health systems tap energy-as-a-service to ease financial pressure
More health systems are signing energy-as-a-service deals to modernize aging power plants, reduce capital strain and shift resources toward patient care.
Inside the new NYU Langone CEO’s plans for growth
NYU Langone is planning to build a multibillion-dollar academic medical center on Long Island.
Why AI legal liability should be a red flag for health systems
Legal experts say health systems need to be proactive about AI-related legal risks.
Did the Hardest A.I. Problem Just Get Much Easier?
A prominent researcher claims to have a revolutionary approach to “interpretability,” or the science of why A.I. models do what they do. Other experts aren’t so sure.
OpenAI Announces New Discoveries In Mathematics, Computer Science And Physics
OpenAI said its models generated proof that the Exponential Time Hypothesis is false. It also released new results for math and physics problems.
Kenya: 20 Ebola contacts released from quarantine
Twenty people associated with Kenya’s first case of Ebola Bundibugyo virus disease have been reunited with their families after being released from quarantine following completion of the mandatory 21-day monitoring period.
LeBron James, Adam Silver and the NBA’s BIG BET: Is Basketball Walking Into a New Sports Gambling Era?
The NBA is making a massive move into the prediction-market business. And it could change how millions of fans interact with basketball. On Oct. 26, the league announced agreements with Kalshi and Polymarket, naming both companies its preferred prediction-market exchanges. The NBA also signed a memorandum of understanding with the Commodity Futures Trading Commission to…
Tieto sells Pulp, Paper and Fibre software business to Valmet
Tieto has signed an agreement to sell its Pulp, Paper and Fibre software business TIPS to Valmet. TIPS comprises Tieto Indtech’s Manufacturing Execution System (MES) and Order‑to‑Cash solution for the pulp, paper and fibre industry.
Intermountain Health Groundbreaking on a New Era of Children’s Health for Nevada
Nevada’s first stand-alone children’s hospital groundbreaking marks the community-wide effort to build a stronger pediatric health system. Intermountain Health Felicia and Ben Horowitz Children’s Hospital Model presented at groundbreaking for the Intermountain Health Felicia and Ben Horowitz Children’s Hospital LAS VEGAS, Oct. 27, 2026 (GLOBE NEWSWIRE) -- For Media Use, use the following link for photos/videos: https://securedrop.intermountain.net/securedrop/public.php?service=files&t=010f47fe8a
New iMac and 14-Inch MacBook Pro With M6 Chip Expected Tomorrow
After announcing a new iPad mini today, Apple is expected to introduce updated iMac and 14-inch MacBook Pro models with the M6 chip, which debuted in the new Mac mini in August. No design changes have been rumored for these Macs. No design changes have been rumored for these Macs.
What Anthropic’s potential IPO reveals about its business model, growth trajectory, customer base and path to profitability
A UMD Smith expert says Anthropic's IPO filing reveals more than rapid growth, highlighting a predominantly enterprise-focused business with strong customer expansion, improving unit economics and signs of profitability. The filing also offers a rare look at the evolving economics of generative AI.
OpenAI Claims 3 Science Proofs, Taps Shepherds [2026]
OpenAI science discoveries in math, computer science and physics: what the three claims say, what is verified, and how the shepherd model works.
OpenAI Trumpet's 3 More Math and Science Results, Along With a New Plan for Publishing Them
The company has already handed this work over to expert "shepherds" for completion.
Moving past outdated models: a seminar exploring religion and public health
Editors of the Handbook on Religion and Health: Pathways for a Turbulent Future Gary Gunderson and Teresa Cutts (“TC”), visited the Bloomberg School of Public Health on Thursday, Oct. 22 to give their talk “Watersheds: Moving beyond Downstream/Upstream Metaphors to Advance Public Health.”
NASA and USDA sign agreement to expand Earth science and agriculture collaboration
NASA and the U.S. Department of Agriculture (USDA) have signed a Memorandum of Understanding to expand cooperation in Earth observation, geospatial analytics, and advanced data technologies, as part of USDA’s data modernisation plan for U.S. agriculture.
Ollama for Mac gains support for local text-to-speech models
Ollama, the popular app for running AI models locally, announced that its Mac app now supports text-to-speech generation, with Windows and Linux support coming soon.
The vaginal microbiome may relate to more than reproductive health
Researchers analyzed vaginal microbiota, metabolites, and psychological questionnaire scores in 105 young Italian women and found associations between microbial community types and reward responsiveness, motivational drive, and behavioral inhibition. Exploratory models identified statistical links involving vaginal GABA and valine, but the cross-sectional study could not establish whether microbiome changes influence psychological functioning or the reverse.
Tom Brady, Candice Swanepoel have been dating since June: report
Football hero Tom Brady and supermodel Candice Swanepoel have reportedly been dating since June. The pair have kept the relationship quiet by spending time together in Indian Creek, Fla., 30
HHS finalizes health IT rule cutting certification criteria
The HTI-5 final rule reduces requirements for developers participating in the ONC Health IT Certification Program.
Report: Silent Hill 1 Remake Targeting 2027 Release, First Cast Details Revealed
Following the critical and commercial success of the Silent Hill 2 remake, fans were left eager for more modern takes on classic entries. Bloober Team answered that call last year…
watchOS 27.2 available now for Apple Watch, here’s what’s new
watchOS 27.2 is rolling out now for Apple Watch users alongside visionOS 27.2 and more. Here’s what’s new.
Eric Bauza dead: Voice actor who voiced modern 'Looney Tunes' was 46
Voice actor Eric Bauza died Sunday of natural causes at age 46. His career spans more than two decades and includes credits for modern 'Looney Tunes' projects, 'Rick and Morty' and 'Unikitty!'
Humans Accidentally Canceled the Next Ice Age, Scientists Say
This finding underscores the incredible, planet-altering power of greenhouse gas emissions.
Eric Bauza, modern voice of Looney Tunes characters, dies at 46
Eric Bauza, the award-winning voice actor whose performances of Bugs Bunny, Daffy Duck and many more characters made him the modern voice of Looney Tunes, has died. He was 46.
Zelda 40th Anniversary Switch 2 Pro Controller restock tracker: we’re watching these retailers
🎮 Nintendo will release a Zelda 40th anniversary Switch 2 Pro Controller on October 29 💰 It costs $99.99, the same as other limited editions 📅 A restock could occur on launch day at Walmart and Best Buy 🚨 Our Zelda Switch 2 Pro Controller restock tracker @mattswider on X will send out an alert when stock appears Walmart: Zelda Pro Controller Best Buy: Zelda Pro Controller Amazon: Zelda Pro Controller Target: Zelda Pro Controller GameStop: Zelda Pro Controller Nintendo is releasing a special limited edition Nintendo Switch 2 Pro Controller to celebrate the 40th anniversary of The Legend of Zelda series. It releases on October 29, 2026, which is when we expect to see a long-awaited restock of the hard-to-find controller. 🚨 We’re tracking Zelda Switch 2 Pro Controller stock updates. If you’d like to know when more stock arrives, follow Matt Swider on X and turn on notifications. You can also become a free or paid subscriber to The Shortcut to help support our work. 🚨 The Switch 2 Pro Controller features the same striking gold and royal emerald color scheme of the Nintendo Switch 2 The Legend of Zelda 40th anniversary edition, and also includes a fun little easter egg on the back: an 8-Bit Link. 🚨 Want the Zelda 40th Anniversary Switch 2 Pro Controller? Drop your email for restock alerts before it sells out. ⤵️ Subscribe This is the same Nintendo Switch 2 Pro Controller we’re used to, aside from the intricate design, but it means you’ll have to pay more as a result. It costs $99.99 instead of the standard $89.99. However, the Pro Controller is the easiest way to play the best Switch 2 games in TV mode. If you’ve been searching for a Zelda 40th Anniversary Switch 2 Pro Controller restock, here’s everything you need to know. Zelda 40th anniversary Switch 2 Pro Controller should restock at these retailers We’ve seen retailers such as Walmart and Best Buy restock items on release day, even when pre-orders have sold out. It’s likely that the Zelda Switch 2 Pro Controller will be up for grabs on October 29, 2026, when the controller and console launches. Demand will be high, and stock could sell out fast. However, we’ll be keeping a close eye on every major retailer, including Target, Amazon, GameStop, and the Nintendo Store and will alert our followers as soon as stock goes live. Why you can trust our Zelda Switch 2 Pro Controller restock tracker We’ve already helped over 400,000 people buy a PS5 when it was in and out of stock during Covid, and we’ve helped our subscribers continue to secure hard-to-find items. The Shortcut followers were some of the first to secure the Switch 2 when it went on sale, and we’ve also helped countless others snag limited edition consoles like the PS5 30th anniversary edition. The Shortcut and Matt Swider on X offer exclusive Zelda 40th anniversary Switch 2 Pro Controller restock updates with up-to-the-second US store inventory checks at the biggest retailers. You’ll receive an instant notification on X (if set to on) as soon as new stock arrives. Up next: Call of Duty: Modern Warfare 4 review roundup: ‘a strong return to form’ Subscribe Adam Vjestica is The Shortcut’s Senior Editor. Formerly TechRadar’s Gaming Hardware Editor, Adam has also worked at Nintendo of Europe as a Content Marketing Editor, where he helped launch the Nintendo Switch. He also runs a retro gaming YouTube channel called Game on, boy! Follow him on X @ItsMrProducts.
MARVEL Cosmic Invasion DLC ‘The Siege of Castle Doom’ reveals new game mode
Publisher Dotemu and developer Tribute Games have released a new trailer for MARVEL Cosmic Invasion paid downloadable content “The Siege of Castle Doom” introducing new game mode “…
Marvel Cosmic Invasion Lands New Roguelike Game Mode In Upcoming Doomsday-Themed DLC
Dormammu, I've come to bargain
Anthropic wants investor money — but doesn't give them decision power
Dario Amodei and his cofounders will be happy to sell you shares in their AI giant. But you won't get a voice in the way they run their company.
Final Fantasy And Chrono Trigger Veterans Believe Modern Developers Must Possess Skill To Take An Idea 'From 0 To 1' In The Age Of AI
Yoshinori Kitase and other Square Enix creatives also reflected on the SNES development of the Mana series
Owners of Elvis Presley’s music sue Anthropic over un-permissioned AI use
The owners of Elvis Presley’s music are suing Anthropic for using the rock icon’s songs without permission to train AI models. Much has been made of the theft component inherent
📈 Monday data: The bottleneck isn’t intelligence
In the AI Investment Brief today: CapEx updates and lease commitment breakdowns Anthropic co-founder Jack Clark recently said in a speech at the IMF that the singularity has begun: For many years, researchers and science fiction authors have forecast a future in which AI systems drastically increase the pace of overall scientific and technical progress, making things move so quickly that it is hard for humans to keep up. They call this the singularity. I believe that this year we have gained convincing evidence that it has now begun. This follows Anthropic’s claim that in August, 26% of its AI R&D was led by Claude, with a human supervising its work. In October, OpenAI posted 719 math manuscripts1 made by its internal model. Math and coding are two fields where a research loop can close without leaving the desk. But can the loop close in the rest of science? Subscribe The loop is real The idea is not new. Mathematician Irving John Good, who had worked with Alan Turing at Bletchley Park, argued that a machine smarter than us “could design even better machines; there would then unquestionably be an ‘intelligence explosion,’ and the intelligence of man would be left far behind.” The Gödel machine, a self-improving computer that can rewrite its own code better than its prior, was first proposed in 2003. In 2025, researchers at Sakana AI and the University of British Columbia set out to show that this was possible. Their agents iteratively improved their own code through a feedback loop, resulting in gains of 30 pp on SWE-bench and more than 15 pp on Polyglot, testing coding skills beyond Python. The idea has since been tested in other labs. A Gemini-powered agent called AlphaEvolve found a faster matrix multiplication kernel used for training Gemini, speeding up the kernel by 23% and cutting Gemini’s training time by 1%. In China, MiniMax reported that its M2.7 model worked on improving its own agent’s harness, skills, sampling and memory. Over 100 rounds of rewriting led to a 30% gain, per its internal evaluations. In each case, what was being rewritten was not the model itself but everything around it. Is it better than human work? In September this year, in what seemed like a milestone, an AI-built agent proved as good at improving other AI agents as a human-built one. It did that in what appeared to be half the steps. But the result was inconclusive: the differences between runs were greater than the difference between the AI- and human-built agent results. Nonetheless, this is increasing the chatter around recursive self-improvement (RSI) in AI. Google’s Sundar Pichai said that “you have RSI loops along with AI researchers in various aspects of model development.” Sakana AI published a paper on RSI through multi-agent collaboration, finding that after two cycles its system scored 1.2–1.6x better per output token than the base model across four research benchmarks. Ramez Naam challenges that view. He splits AI self-improvement into five overlapping types. The first four describe how autonomous the AI is; so far, only types 1 and 2 have been observed. The fifth type describes accelerating returns, and he notes that greater autonomy doesn’t guarantee a takeoff scenario. Instead, each round of self-improvement would need to deliver at least as much as the last. The results from Sakana, AlphaEvolve and MiniMax above might look like type 3 or type 4 autonomy. But in each case, the AI wasn’t updating its own weights directly, only the ancillary parts — the harness, the memory. And where Claude leads its own R&D, for now a human still supervises.
Apple Raises iPad and Mac Trade-In Values
Apple today updated its U.S. trade-in estimates, raising maximum values across the iPad lineup and for most Macs following today's announcement of the new iPad mini. Every iPad category has gained value, although the increases are relatively modest. The iPad mini and standard iPad both rise by $20, while the iPad Air gains $15 and the iPad Pro increases by $10.
AGFA HealthCare Selected by Infirmary Health to Modernize Imaging Across Its Health System
Enterprise Imaging Cloud investment advances Infirmary Health's strategy to modernize imaging, simplify radiology workflows and create a scalable foundation for continued growth.CARLSTADT, NJ / ACCESS Newswire / October 26, 2026 / Infirmary Health has selected Enterprise Imaging Cloud (SaaS) to modernize its radiology imaging environment and establish a foundation for a broader Enterprise Imaging strategy across the health system.
Eric Bauza, modern voice of Looney Tunes characters, dies at 46
The modern voice of Looney Tunes has died.
Eric Bauza, modern voice of Looney Tunes characters, dies at 46
The modern voice of Looney Tunes has died | NewsRadio 1080 KRLD
Eric Bauza, modern voice of Looney Tunes characters, dies at 46
The modern voice of Looney Tunes has died.
Eric Bauza, modern voice of Looney Tunes characters, dies at 46
The modern voice of Looney Tunes has died.
University of Detroit Mercy lands $7.75M defense grant to grow cybersecurity, AI workforce pipeline
The funds are to help address workforce shortages in advanced technological disciplines essential to modern military operations and applicable to civilian life.
Converting PSVs for Expedition Cruising Creates Compelling Business Model
Architect and yacht designer Stefano Pastrovich has developed a novel concept that he believes can create a compelling business model and entry for bo...
New zebrafish models could help test treatments for mental health conditions
A humble fish can experience features of mental health conditions such as schizophrenia and autism, raising the possibility that some of our most complex social behaviors may be more deeply encoded in ...
Daymark Health Oncology, Palliative Model Reduces Hospitalizations, Costs
An in-home and virtual supportive oncology care program by Daymark Health was associated with fewer hospital admissions and lower overall health care
Quantum Art Research Outlines More Efficient Quantum Approach to Wave Modeling
Insider Brief Quantum Art presented research on a quantum algorithm that uses known wave physics to simplify large-scale wave simulations, with potential
Some iPhone Duo Models Are Breaking. iFixit’s Teardown Might Explain Why
The repair company iFixit released its repairability rating for Apple’s very first foldable iPhone. It comes as users report a wave of cracked-screen issues.
SCC To Host Modern Hair Care Science: From Follicle to Formulation
The majority of the program focuses on formulation strategies for key product categories including shampoos, conditioners, styling products and scalp treatments.
Scientists Built a Virtual ‘Torture Chamber’ for AI. What It Revealed Is Deeply Unsettling.
Researchers searched for a signal of pain inside large language models—and they may have actually found one.
A Dead Salmon's Fake Brain Activity Still Haunts Science, and AI Tools Can Fall for the Same Trap
A dead salmon once showed fake brain activity on an fMRI scan. Now AI researchers say tools that explain AI models face the same statistical trap.
Purdue and Accenture: A model for applied partnership
Artificial Intelligence is reshaping every industry. Find out how Purdue and Accenture are working together to prepare Indiana’s workforce and students in Purdue’s Mitch Daniels School of Business for an AI-powered future.
NASA Plans Faster, Cheaper Picks for Space Science Missions: What Changes
NASA says its new Competition Model 2.0 will cut the time to pick some science missions from 35 months to about 19.5 and make small missions a one-step process.
CleanYourTV 3.0 Lets You Remove Ads And Bloatware From Android And Google TVs, Now Supports 300 Models
CleanYourTV 3.0 enhances smart TV experience with ad-blocking, compatibility for 300 models, and an easy phone setup, gaining 37,000+ GitHub stars.
Modi Rosenfeld, Jackie Goldschneider to headline Jewish entertainment panel
JOIN Israel will bring together Jewish entertainment professionals on Nov. 12 to discuss identity, representation and stereotypes while raising funds for elderly Israelis in need.
New Allied Health Concentration Fuses Healthcare Delivery with Emerging Technologies
The new Digital Health and Technology concentration gives UConn students firsthand experience with the tools transforming modern healthcare and build skills ...
Ebola: UN officials condemn killing of nurse in DR Congo
The UN’s Ebola coordinator and the head of the World Health Organization (WHO) have deplored the killing of a nurse working to halt the spread of the disease in the Democratic Republic of the Congo (DRC).
Exclusive-US Political Candidates Tailor Messages for AI Models Used by Voters
By Mike Stone WASHINGTON, Oct 26 (Reuters) - US political candidates have been engineering their campaign messages to appeal to the AI chatbots that more voters have been using to answer questions about issues, and documents seen by Reuters have revealed some of their strategies. One Powerpoint ...
Makana Eyre: Polynesian Health Overlooked In Buzz Over Landmark Study
The study provided insights into the origins of Native Hawaiians. More consequential is what this “genetic treasure trove” means for people with rare DNA mutations.
What to expect from the 2027 Medicare outpatient pay final rules
Medicare payment rules for outpatient care are due within days.
Islanders News: Did not do Dallas
The Islanders were leaky all over in Dallas, almost like they have a declining defense outside of Matthew Schaefer. The 6-3 loss to the Stars was not surprising overall, but it did end a modest points streak and exposed some holes that Pete DeBeor has been working to cover. Islanders News Elsewhere
Apple Will Reportedly Stop Making You Feel Like a Thief When You Return an Unopened iPhone
Opening your unopened box just felt aggressive.
Micro1 invests $1B to license data for AI model development
Micro1 is pledging $1 billion to gobble up more companies' internal data for licensing to AI model developers, part of a new wave for the tech.
How Beacon Health System Closed an 8,000-Patient Care Gap in Under Eight Weeks
Beacon Health System used agentic AI to reach 8,000 overdue patients, improve colorectal cancer screening and generate measurable ROI.
Smithsonian scientists launch "Lumina" simulation to model early universe
Researchers introduce "Lumina," a massive cosmological radiation-hydrodynamics simulation designed to model the universe's first two billion years
12 AI models were asked what they really think about humans — and almost all agreed on one uncomfortable truth
29 of 35 responses shared the same theme
What is optogenetics? The Nobel-winning science explained
From light to insight: Exploring optogenetics in brain science
Psychology says children who carry the same toy from room to room may be seeking more than entertainment
it offers familiarity, comfort and a sense of security as they navigate an unfamiliar or overwhelming world.
Scientists discover Arctic sea ice loss could be far worse than predicted
Arctic winter sea ice could disappear much faster than scientists previously expected, according to new research using climate clues from 6,000 years ago. By comparing ancient ocean sediments with modern climate models, researchers found that future winter ice coverage may be roughly one million square kilometers smaller than earlier predictions suggested.
Sports equinox 2026: Date, schedule, meaning and history behind the rare event
The 33rd sports equinox will occur in 2026.
Lawmakers propose $11M fix to restore school sports and activities funding
by Katie Klingsporn, WyoFile Wyoming’s new school funding model added more than $250 million in state education funding, including for widely supported
Primark's Business Doesn't Make Sense
In a world where fast fashion giants like Shein, Zara, and H&M drop thousands of new styles every day — and rake in billions through e-commerce — Primark is doing the unthinkable: thriving with zero online shopping. So what gives?*Want to Know the 5 Trends Changing Modern Retail? Find Out Here:* 🔗 https://clickhubspot.com/d13ac2In this video, we take you inside Primark’s weirdly brilliant business model — a model that’s stuck in the past on purpose. From warehouse optimization and floor-ready freight shipments to why the pandemic didn’t push them online, we unpack how this low-cost retail giant has managed to defy digital norms… and make it work.This isn’t just about one brand. It’s a story about modern retail expectations — and what it actually takes to meet (or reject) them.Subscribe to The Hustle:🔗 https://clickhubspot.com/vu3lGet the 5-minute newsletter keeping 2M+ innovators in the loop🔗 https://clickhubspot.com/3klnAbout HubSpot: HubSpot is a customer platform that provides education, software, and support to help businesses grow better. The platform includes marketing, sales, service, commerce, operations, and website management products that start free and scale to meet our customers’ needs at any stage of growth. Today, thousands of customers around the world use HubSpot’s powerful and easy-to-use tools and apps to attract, engage, and delight customers.#TheHustle #HubSpot
Queen of Halloween Heidi Klum teases costume with mysterious image
“What’s my costume?,” the model asked fans alongside a strange close-up photo.
‘You Can See Everything’ surges with $19.5M at box office; ‘Clayface’ takes No. 1
DC Studios scored a modest, R-rated win with “Clayface,” landing a $24 million opening weekend, according to studio estimates Sunday.
'You Can See Everything' surges with $19.5M at box office; 'Clayface' takes No. 1
DC Studios scored a modest, R-rated win with “Clayface,” landing a $24 million opening weekend, according to studio estimates Sunday | KCBS All News 106.9FM and 740AM
'You Can See Everything' surges with $19.5M at box office; 'Clayface' takes No. 1
DC Studios scored a modest, R-rated win with “Clayface,” landing a $24 million opening weekend, according to studio estimates Sunday | KNSS Radio
'You Can See Everything' surges with $19.5M at box office; 'Clayface' takes No. 1
DC Studios scored a modest, R-rated win with “Clayface,” landing a $24 million opening weekend, according to studio estimates Sunday.
'You Can See Everything' surges with $19.5M at box office; 'Clayface' takes No. 1
DC Studios scored a modest, R-rated win with “Clayface,” landing a $24 million opening weekend, according to studio estimates Sunday | KMBZ
'You Can See Everything' surges with $19.5M at box office; 'Clayface' takes No. 1
DC Studios scored a modest, R-rated win with “Clayface,” landing a $24 million opening weekend, according to studio estimates Sunday.
'You Can See Everything' surges with $19.5M at box office; 'Clayface' takes No. 1
DC Studios scored a modest, R-rated win with “Clayface,” landing a $24 million opening weekend, according to studio estimates Sunday. But the biggest success story in theaters remained A24’s...
'You Can See Everything' Surges With $19.5M at Box Office; 'Clayface' Takes No. 1
NEW YORK (AP) — DC Studios scored a modest, R-rated win with “Clayface,” landing a $24 million opening weekend, according to studio estimates Sunday. But the biggest success story in theaters remained A24’s Elizabeth Holmes documentary “You Can See Everything,” which pulled in $19.5 million in its ...
'Tokens Are Cheap': Open Source Subreddit Bans AI
“AI, as it exists today, is incongruent to this Open Source community.”
#ESMO26: Merck and Moderna's cancer vaccine data were 'a triumph of science.' And now, the work begins
Merck and Moderna’s intismeran cut melanoma recurrence risk 42% at ESMO; experts weigh other tumors, manufacturing and boosters.
ESMO: Roche touts ‘convincing’ phase 3 KRAS data after win over rivals
Roche has shed more light on its investigational KRAS G12C inhibitor's phase 3 victory over Amgen’s Lumakras and Bristol Myers Squibb’s Krazati. The open-label Krascendo 1 trial enrolled 338 people with previously treated KRAS G12C-mutated non-small cell lung cancer (NSCLC). Patients who had already received a KRAS G12C inhibitor or pan-KRAS/RAS inhibitor were excluded from the trial. Participants received either divarasib once daily, Lumakras once daily or Krazati twice daily. Roche announced back in July that divarasib had demonstrated statistically significant improvements in progression-free survival (PFS) and overall survival (OS), meeting the trial’s primary and key secondary endpoints. But the Swiss pharma had been holding back the detailed data until now. At the European Society for Medical Oncology (ESMO) Congress in Madrid, Roche revealed that median OS for the 167 patients who received divarasib was 17.7 months, compared to 12 months for the 171 patients who received Lumakras or Krazati. The benefit was similarly clear when it came to median PFS, which stood at 9.8 months versus 5.7 months, respectively. A total of 44% of patients receiving divarasib were alive without disease progression at one year, compared to 24% of the control group, according to Roche’s presentation. It was a similar story for the objective response rate, which came in at 58% for divarasib versus 32% for the control group, while median duration of response was 11.9 months versus 6.9 months. Stefan Frings, M.D., Ph.D., deputy chief medical officer at Roche Pharma, told Fierce that the data made for a “very comprehensive, strong package, which should be convincing to health authorities.” “It’s an important advance for patients with lung cancer,” Frings said in an interview at a Madrid hotel during the conference. “It's a second-line setting, and patients who receive divarasib benefit compared to the current first-generation KRAS G12C inhibitors by having far longer overall survival,” he continued. “They live longer. They have better progression-free survival, better response rates, and with a safety profile which is—if [anything]—even better,” he said. According to Roche, 4.8% of patients receiving divarasib discontinued treatment due to treatment-related adverse events, compared to 11.7% in the control group. Serious treatment-related adverse events were also less common with divarasib, at 7.8% versus 15.2%. Roche’s confidence in divarasib had been building even before this phase 3 success. The candidate had already shown better potency and selectivity than the incumbent KRAS G12C inhibitors Krazati and Lumakras in preclinical tests. After cross-trial comparisons suggested that the edge translated into better clinical outcomes, Roche axed a study comparing divarasib to the chemotherapy docetaxel and went toe-to-toe with Lumakras and Krazati. “We designed the drug on purpose with higher potency and better selectivity,” Frings explained. “So, based on preclinical models, we clearly knew it would be superior to the first generation.” “It’s honestly not so frequent that pharma companies go head-to-head,” he added. “But if you want to make a point, if you want to convince payers, prescribers and patients … then a head-to-head win is rather rewarding.” While Amgen and BMS reached the regulatory finish line first for KRAS G12C-mutated, locally advanced or metastatic NSCLC in 2021 and 2022, respectively, they have struggled to capitalize on their head start. Krazati brought in $55 million for BMS in the second quarter, while Lumakras delivered $111 million to Amgen. For its part, Roche is aiming for peak divarasib sales of 1 billion to 2 billion Swiss francs ($1.2 billion to $2.5 billion), according to Frings. The Big Pharma is currently recruiting patients into a phase 3 trial comparing divarasib plus Keytruda against Keytruda plus chemotherapy in previously untreated advanced or metastatic nonsquamous KRAS G12C-mutated NSCLC. Roche has previously suggested that sales in metastatic disease would account for most of the forecast. Frings was tight-lipped on the exact timeline for a regulatory filing but said the Swiss pharma is “certainly keen to get this to as many patients as possible around the world.” Roche has more RAS drugs coming up behind divarasib. The pharma has already launched phase 1 trials of a pan-RAS inhibitor called RG6505 and a KRAS G12D inhibitor dubbed RG6620 in solid tumors. Roche’s partner Chugai Pharmaceutical is also testing a pan-KRAS inhibitor called AUBE00. Roche has made a “deliberate effort” to test a range of RAS drugs, Frings said. “If you have many rare mutations and you are scrambling to find sufficient patients, a pan-RAS inhibitor makes a lot of sense,” he explained.
Modders Unlock GeForce RTX 20, 30 And 40 GPUs For Up To 2X Compute Gains
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