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ESMO: Roche touts ‘convincing’ phase 3 KRAS data after win over rivals
Roche has shed more light on its investigational KRAS G12C inhibitor's phase 3 victory over Amgen’s Lumakras and Bristol Myers Squibb’s Krazati. The open-label Krascendo 1 trial enrolled 338 people with previously treated KRAS G12C-mutated non-small cell lung cancer (NSCLC). Patients who had already received a KRAS G12C inhibitor or pan-KRAS/RAS inhibitor were excluded from the trial. Participants received either divarasib once daily, Lumakras once daily or Krazati twice daily. Roche announced back in July that divarasib had demonstrated statistically significant improvements in progression-free survival (PFS) and overall survival (OS), meeting the trial’s primary and key secondary endpoints. But the Swiss pharma had been holding back the detailed data until now. At the European Society for Medical Oncology (ESMO) Congress in Madrid, Roche revealed that median OS for the 167 patients who received divarasib was 17.7 months, compared to 12 months for the 171 patients who received Lumakras or Krazati. The benefit was similarly clear when it came to median PFS, which stood at 9.8 months versus 5.7 months, respectively. A total of 44% of patients receiving divarasib were alive without disease progression at one year, compared to 24% of the control group, according to Roche’s presentation. It was a similar story for the objective response rate, which came in at 58% for divarasib versus 32% for the control group, while median duration of response was 11.9 months versus 6.9 months. Stefan Frings, M.D., Ph.D., deputy chief medical officer at Roche Pharma, told Fierce that the data made for a “very comprehensive, strong package, which should be convincing to health authorities.” “It’s an important advance for patients with lung cancer,” Frings said in an interview at a Madrid hotel during the conference. “It's a second-line setting, and patients who receive divarasib benefit compared to the current first-generation KRAS G12C inhibitors by having far longer overall survival,” he continued. “They live longer. They have better progression-free survival, better response rates, and with a safety profile which is—if [anything]—even better,” he said. According to Roche, 4.8% of patients receiving divarasib discontinued treatment due to treatment-related adverse events, compared to 11.7% in the control group. Serious treatment-related adverse events were also less common with divarasib, at 7.8% versus 15.2%. Roche’s confidence in divarasib had been building even before this phase 3 success. The candidate had already shown better potency and selectivity than the incumbent KRAS G12C inhibitors Krazati and Lumakras in preclinical tests. After cross-trial comparisons suggested that the edge translated into better clinical outcomes, Roche axed a study comparing divarasib to the chemotherapy docetaxel and went toe-to-toe with Lumakras and Krazati. “We designed the drug on purpose with higher potency and better selectivity,” Frings explained. “So, based on preclinical models, we clearly knew it would be superior to the first generation.” “It’s honestly not so frequent that pharma companies go head-to-head,” he added. “But if you want to make a point, if you want to convince payers, prescribers and patients … then a head-to-head win is rather rewarding.” While Amgen and BMS reached the regulatory finish line first for KRAS G12C-mutated, locally advanced or metastatic NSCLC in 2021 and 2022, respectively, they have struggled to capitalize on their head start. Krazati brought in $55 million for BMS in the second quarter, while Lumakras delivered $111 million to Amgen. For its part, Roche is aiming for peak divarasib sales of 1 billion to 2 billion Swiss francs ($1.2 billion to $2.5 billion), according to Frings. The Big Pharma is currently recruiting patients into a phase 3 trial comparing divarasib plus Keytruda against Keytruda plus chemotherapy in previously untreated advanced or metastatic nonsquamous KRAS G12C-mutated NSCLC. Roche has previously suggested that sales in metastatic disease would account for most of the forecast. Frings was tight-lipped on the exact timeline for a regulatory filing but said the Swiss pharma is “certainly keen to get this to as many patients as possible around the world.” Roche has more RAS drugs coming up behind divarasib. The pharma has already launched phase 1 trials of a pan-RAS inhibitor called RG6505 and a KRAS G12D inhibitor dubbed RG6620 in solid tumors. Roche’s partner Chugai Pharmaceutical is also testing a pan-KRAS inhibitor called AUBE00. Roche has made a “deliberate effort” to test a range of RAS drugs, Frings said. “If you have many rare mutations and you are scrambling to find sufficient patients, a pan-RAS inhibitor makes a lot of sense,” he explained.
Nonprofit organizes ‘silkies’ hike to support military members’ mental health
Veterans, active military service members and community supporters recently gathered for a hike organized by a nonprofit dedicated to suicide prevention.
Obama, in Midwest, assails 'cruelty' and indecency from Trump and his allies in the midterm campaign
Obama remains the Democratic Party’s best motivator nearly a decade after leaving the White House. And he's taking his star power on the road in the final days of the midterm elections, which will help determine the balance of power in American politics on Nov. 3.
After win over Ole Miss, Texas QB Arch Manning says that he 'kind of likes being disregarded'
Names in the News: People shaping the future of Lake Area business
The Sculptry promotes staff The Sculptry, Southwest Louisiana’s premier medical aesthetics clinic, has expanded its leadership team with the announcement of new positions for key staff members. Amber Pauley, RN, […]
U of M fellowship aims to boost rural obstetrics training and keep labor and delivery units open
The partnership is launching the new, one-year family medicine obstetrics fellowship next summer to prepare family medicine physicians to provide advanced prenatal, maternity and newborn care in rural communities. The only other fellowship of this kind in Minnesota is at Essentia Health in Duluth.
Sunday Night Football: How to watch the Kansas City Chiefs vs. Seattle Seahawks game tonight
Sarkozy's son warns violent protests in France could worsen amid political unrest
Louis Sarkozy, son of former French President Nicolas Sarkozy, discusses violent unrest in France, the influence of far-left groups and the country’s immigration and economic challenges.
Los Angeles Rams vs. Las Vegas Raiders: How to watch the NFL Week 7 game, channel, streaming info and more
Green Bay Packers vs. Detroit Lions: How to watch the NFL Week 7 game, channel, streaming info and more
Cincinnati Bengals vs. Baltimore Ravens: How to watch today, start time, where to stream and more
YouTube Gold: Highlights From Louisville’s Trip To Kansas
Kansas lost Wednesday, but the Jayhawks are not exactly pushovers
What lymphatic drainage tools can and can’t do for your health
Influencers swear by lymphatic drainage to allegedly reduce puffiness, contour their faces and bodies, and boost overall health. We asked experts if you should just save your money.
New York Giants vs. Houston Texans: How to watch the NFL Week 7 game, channel, streaming info and more
Pittsburgh Steelers vs. New Orleans Saints: How to watch the NFL international game today, start time, where to stream and more
Snap a daily joy photo, snack on pumpkin seeds and try this logic puzzle — plus 5 more health tips to help you have a great week
Health hacks for the week ahead — including how walking can help get you out of a rut.
3 mental health habits that may help your blood pressure
Exercising and eating a healthy diet are important. But your mindset may benefit your health, too.
He left the CDC to fight RFK Jr. But was it better to fight from within?
Demetre Daskalakis, CDC’s top immunization official, resigned in 2025 to protest Health Secretary Robert F. Kennedy Jr., then became one of his loudest critics.
These are the midterm deciders: They voted for Trump and now disapprove of him
About a fifth of those who voted for Trump in 2024 now disapprove of his performance. How they vote -- or whether they stay home -- will strongly shape the scale of Republican losses this year.
Trump started a trade war with Canada. GOP candidates became casualties.
High tariffs on Canadian goods have turned into a liability for Republicans in key midterm races, particularly those in northern border states.
GMA News
DOOMSDAY IS COMING! 🎬 LOOK: Marvel Entertainment drops a new trailer for the upcoming "Avengers: Doomsday" movie, featuring Chris Evans as Captain America, Chris Hemsworth as Thor, and a look at...
That Girl Boina: How employee theft is hurting small businesses in Africa
That Girl Boina's post about why she had closed her beauty parlour struck a nerve with other small business owners.
‘It’s magic’: scientists rediscover how to make ancient Roman colour-changing glass
Exclusive: Optical engineering that went into 1,600-year-old Lycurgus Cup has baffled experts for centuries
Yahoo Top 10: BYU's stunning upset loss shakes up college football picture
Misery Index: Texas Tech's big money and bigger talk can't save it from embarrassing loss
Jaylen Brown responds to Jayson Tatum's 'no beef' comments as dispute continues: 'He's got a great PR team'
Kochetkov Earns Shutout
Pyotr Kochetkov improved his record to 7-0-0 with a 24 save shutout and the Carolina Hurricanes defeated the St. Louis Blues on Saturday night, 4-0. The Hurricanes now have a 9-2-2 record and their 20 points put them at first place in the league, (for now). The Canes finished up their road trip with a […]
Carolyn Hax: Her parents know all their business. That’s weird, right?
Now that they’re living together, letter writer wants to ask girlfriend for “more typical” communication with her parents.
Adams County Health Department participates in Drug Take Back Day 2026
For Drug Take Back Day, people were encouraged to drop off expired or unwanted medicine and prescription at Adams County Health Department Saturday.
Lawrence Healthcare holds community health fair
Big wheels and free health screenings drew local families out to Walnut Ridge on Saturday morning for an annual community health fair and Touch-a-Truck. The event was hosted by Lawrence Healthcare, a hospital in town.
Miami's Israeli gold rush: Michelin-starred restaurants, billion-dollar deals and booming businesses
From a Michelin-starred kosher restaurant and Eyal Shani's growing presence to massive real estate deals, Israeli businesses are flourishing in Miami; but soaring costs, bureaucracy and distance from family are testing the American dream
14-year-old entrepreneur’s slim business reaches millions online
A 14-year-old entrepreneur’s slime business has reached millions online and gained 21,000 followers in 23 days.
UCF outlasts No. 2 BYU in 2OT, notches first top-5 win in program history: 'That's the weirdest end of a game I've ever seen'
Scott Frost's Knights came out on top of a doozy.
Pfizer And 2 Other AI Healthcare Stocks To Watch
Warning signs around heavily indebted AI infrastructure firms have grown louder after analysts raised the risk of a tech debt spiral, with some newer players struggling to finance data centers and high-end chips. That strain shifts attention toward more grounded uses of AI that address urgent problems such as healthcare. Investors seeking substance over hype may find this article useful. It profiles three AI powered healthcare stocks from our screener. The three stocks covered below are a...
Obama rips into Ramaswamy over attack ad: ‘There’s no line he won’t cross’
The Ramaswamy campaign cut in half the length of the ad featuring Amy Acton’s estranged mother after the spot sparked an uproar.
Trump, Who Once Called Early Voting ‘Ridiculous,’ Casts a Midterm Ballot
The president voted at a polling station in Palm Beach County, Fla.
Trump casts his midterm ballot early in Florida
Trump has been criticized in the past for voting by mail despite his long history of railing against that method of submitting ballots.
In first midterm rally, Obama blasts Trump administration
Democrats have embraced the former president as their most effective closing messenger in the final weeks of the high-stakes midterm campaign.
Show-Me-State Politics: School districts oppose Missouri's new grading system; state auditor's race
KY3's Tyler Wayne and Missouri Capitol Bureau Chief Hannah Falcon look at this week in Show-Me-State politics.
Show-Me-State Politics: School districts oppose Missouri's new grading system; state auditor's race
KY3's Tyler Wayne and Missouri Capitol Bureau Chief Hannah Falcon look at this week in Show-Me-State politics.
Show-Me-State Politics: School districts oppose Missouri's new grading system; state auditor's race
KY3's Tyler Wayne and Missouri Capitol Bureau Chief Hannah Falcon look at this week in Show-Me-State politics.
Republican billionaire Rick Jackson is walking a Trump tightrope in his quest to lead Georgia
Jackson’s path differs from Donald Trump’s, and the 72-year-old healthcare magnate and investor brings a vastly different persona to his first campaign. Unlike Trump, who was born to wealth, Jackson spent his early years bouncing through foster homes before launching his first company as a young man.
Kukakuka with Naka: Hawaii business filings delayed six weeks into DCCA Salesforce backlog
Hawaii businesses face six-to-eight-week DCCA delays amid Salesforce backlog after CNBC ranked state worst for business.
Pittsburgh Steelers vs. New Orleans Saints: How to watch the NFL international game, start time, where to stream and more
Find out how to watch the Pittsburgh Steelers vs. New Orleans Saints NFL Paris game this week.
New York state woman charged with voting illegally says she recently learned she wasn’t a citizen
Marva Cook was adopted as a toddler and had always assumed she was a U.S. citizen, she told Homeland Security investigators earlier this month, according to the criminal complaint.
Ric Flair health update after wrestling legend hospitalized hours after revealing blood clot
Flair is a two-time WWE Hall of Famer and widely considered to be one of the greatest talents in pro-wrestling history.
Many called to mental health field despite challenges
State making new scholarships available
What's going on with Dan Sullivan and Dan Sullivan? The Alaska Senate litigation, explained
One of them is a Republican senator and ally of the president. The other is a retired schoolteacher whom Republicans accuse of being a Democratic plant to siphon away votes.
The Largest Planetariums In The United States
The Largest Planetariums In The United States ranked by dome size, led by Jersey City, with St. Louis, Los Angeles, San Francisco, and Chicago close behind.
Trump helped make Ossoff a national figure. Nine years later, their rivalry endures.
President Donald Trump and Georgia Sen. Jon Ossoff have each found the other a useful political enemy, one who helps define what they stand for — and against.
U.S. is reducing staffing at 4 Middle East embassies over increased threats from Iran
In a memo sent Friday to Secretary of State Marco Rubio, Director of National Intelligence Jay Clayton said his teams “have received intelligence that Iran has substantially increased efforts to target U.S. personnel.”
Memorial Health System receives donations for mobile health unit
Memorial Health System is giving a big thanks to the Population Health Department’s auxiliary unit for donating a defib and two body mass index monitors to the mobile health unit. These items enhance the ability to provide safe, high-quality care in the communities served. The defib will provide tools to respond effectively during medical emergencies in the field. The BMI...
DOJ orders some California counties to set aside ballots from suspected noncitizens
The letters are the latest escalation in a legal battle between California and President Donald Trump's Department of Justice, which has recently focused on the state in its efforts to root out noncitizen voting ahead of the midterm elections.
College football Week 8 games, schedule, how to watch: Ole Miss vs. Texas, Houston vs. Utah and more
NFL commissioner Roger Goodell on potential Tokyo game: 'It's coming at some point in the near future'
C.E.O.s Say the A.I. Rollout Is Going Well. Employees Feel Differently.
Surveys show workers and executives have different views on A.I.
Houston vs. Utah: How to watch tonight's NCAA college football game, where to stream and more
How to watch the Utah vs. Houston game this Saturday.
Late Kankakee business owner honored with street renaming
Arthur E. Lax, the late owner of Lax Mortuary, had part of a street honorarily named after him by the Kankakee City Council recently.
Ole Miss vs. Texas: How to watch tonight's NCAA college football game, where to stream and more
How to watch the Ole Miss vs. Texas game this Saturday.
Indiana vs. Michigan: How to watch today's NCAA college football game, where to stream and more
How to watch the Indiana vs. Michigan game this Saturday.
‘Made by humans, not AI.’ Why Democrats are shunning fake videos in ads
A clear trend has emerged in the 2026 midterm ad wars: Republicans are embracing AI-generated videos while Democrats are betting they will backfire.
FBI investigating Delaware politician’s alleged ‘bribe’ to primary foe, after WHYY News exposed secretly recorded job offer
New Castle County Recorder of Deeds Mike Kozikowski lost the race to David Tackett, who filed a complaint with prosecutors about the gambit.
How Vivek Ramaswamy’s Ruthless Ad in Ohio Divided Republicans
The fallout from Vivek Ramaswamy’s brutal spot targeting his Democratic rival in the Ohio governor’s race showed that even in the Trump era, a political attack can be seen as going too far.
Woman in ad who said a Democrat endangers kids pleaded guilty to endangering kids
Shellie Flockhart, who called Iowa Democratic House candidate Sarah Trone Garriott “dangerous” for kids, pleaded guilty after authorities said she drove drunk with her children in the car in 2017.
World Series 2026: William Contreras shines with his bat, his arm and his ABS challenges in Brewers' Game 1 victory
Las Vegas Raiders owner Mark Davis honored for mental health efforts
The Las Vegas Raiders owner Mark Davis spoke about his support for mental health.
Las Vegas Raiders owner Mark Davis honored for mental health efforts
The Las Vegas Raiders owner Mark Davis spoke about his support for mental health.
Las Vegas Raiders owner Mark Davis honored for mental health efforts
The Las Vegas Raiders owner Mark Davis spoke about his support for mental health.
Las Vegas Raiders owner Mark Davis honored for mental health efforts
The Las Vegas Raiders owner Mark Davis spoke about his support for mental health.
Jack’s Lantern Trail shines amid business concerns around Iroquois Park
More than 5,000 pumpkins are lighting the way along a quarter-mile trail at Iroquois Park as a longtime Louisville Halloween tradition returns with a new name.
Arts and entertainment throughout the region
A listing of arts and entertainment events throughout the region.
Arts and entertainment throughout the region
A listing of arts and entertainment events throughout the region.
Local business owner faces cleanup after Toledo chemical release
Skyline Party Rentals faces cleanup, lost pay for workers
Politics Unplugged Podcast: Election countdown with Laura Gersony
With Election Day nearing, Arizona’s congressional races are drawing national attention. Arizona Republic reporter Laura Gersony joins Politics Unplugged to break down the high-stakes fights in AZ-01 and AZ-06, where the House majority could be on the line. The conversation examines whether Republican candidates can separate themselves from President Donald Trump as affordability concerns and negative ads dominate the closing days. The episode also looks at outside spending, Elon Musk-backed turnout efforts and the unexpectedly competitive race involving Rep. Eli Crane in northern Arizona. Plus, Dennis Welch and Colin Stanton discuss Arizona’s statewide races, polling, campaign cash and the Valley’s rough sports week.
Politics Unplugged Podcast: Election countdown with Laura Gersony
With Election Day nearing, Arizona’s congressional races are drawing national attention. Arizona Republic reporter Laura Gersony joins Politics Unplugged to break down the high-stakes fights in AZ-01 and AZ-06, where the House majority could be on the line. The conversation examines whether Republican candidates can separate themselves from President Donald Trump as affordability concerns and negative ads dominate the closing days. The episode also looks at outside spending, Elon Musk-backed turnout efforts and the unexpectedly competitive race involving Rep. Eli Crane in northern Arizona. Plus, Dennis Welch and Colin Stanton discuss Arizona’s statewide races, polling, campaign cash and the Valley’s rough sports week.
Florida State Looks to Fix Mistakes Before Season Tips
Florida State faces LSU in its final exhibition game as Luke Loucks looks to fix mistakes, build chemistry and prepare his team for the regular season.
Business pioneer Loida Lewis on leadership, Filipino American representation
In 1974, Lewis became the first Asian and Filipino woman to pass the New York bar without attending a U.S. law school and ran a multinational, billion-dollar company.
Science Hill finishes state runner-up in program's best season
MURFREESBORO — Consider the standard set for Science Hill's volleyball program. The Lady Hilltoppers' best season in program history ended with the team's deepest ever state tournament run.
EAST TEXAS POLITICS: State party chairs weigh in as first week of early voting wraps up
Texas Democratic Party Chair Kendall Scudder and Texas Republican Party Chair D’rinda Randall join Blake Holland on this week’s edition of East Texas Politics on East Texas Now as the first week of early voting wraps up ahead of the November midterm elections.
Rollins says USDA is 'full-bore ahead' on Forest Service reorganization
The Trump administration wants to move Forest Service headquarters from Washington to Salt Lake City, shutter 23 research stations, and close many regional offices and replace them with state offices.
Health Brief: Making sense of Treasury’s biotech deal proposal
Pharma sees a potential catch in Washington’s latest effort to curb China’s biotech ambitions
Political science professor speaks on impact of Harris-Colom rally
A professor said high-profile supporters may motivate voters ahead of midterms.
Seeking to help Collins in Maine, Trump exempts some Canadian imports from his 50% tariffs
Collins, locked in a tight race with Democratic challenger Troy Jackson, issued a statement saying she'd spoken with Trump's top trade negotiator, Jamieson Greer, and Commerce Secretary Howard Lutnick "about the toll tariffs are taking on Maine families, businesses, farmers, and growers.''
How Thomas Jefferson politicked his way into the Louisiana Purchase
WATCH: Trump at GOP rally in Florida revives idea of military intervention in Cuba after Iran
Better Living: The science behind why we get scared
Better Living: The science behind why we get scared
Cook Political moves Ohio governor’s race after Ramaswamy attack ad
The race moved from “toss-up” to “Lean D.”
Why experts are pushing RFK Jr. to release a federal definition of ultraprocessed foods
More than 100 science, medical and nutrition experts signed and sent an open letter Friday to the Office of Management and Budget, urging the administration to release the first-ever government definition of ultraprocessed foods.
DOJ has monitored elections for decades. Here’s why some state officials are concerned this year
The agency regularly monitors polling places. But this year’s effort on Nov. 3 will more than double the number of federal monitors deployed during the 2022 midterms.
Colts QB Anthony Richardson Sr. charged with marijuana possession
A bench trial has been scheduled for Jan. 4, 2027.
Where's Shane? Spookfest at Science City
Shane joins Science City Educators Emma Loesing and Whitney Klaas with Nature Works Educator Ryan Parker to get a sneak peek of this weekend's Spookfest.
Hila and Ethan Klein have made content together since 2011. Now she says he cheated for months.
Hila Klein, who started a YouTube channel with her husband in 2011 that now has 5.4 million subscribers, posted a lengthy statement on Instagram about the alleged affair.