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Xbox Reportedly Bungled $500 Million Netflix Deal
According to industry insiders, newly appointed Xbox CEO Asha Sharma overplayed cross-media potential with recent Netflix exec Peter Rice to the tune of $800 million
Packers' Zaire Franklin Ruled Out vs. Lions
A rare injury blow sidelines the Packers’ defensive workhorse for Sunday’s divisional clash.
NASA’s asteroid Bennu samples reveal a 4.5-billion-year-old secret
Tiny samples from asteroid Bennu are rewriting scientists' understanding of how our Solar System formed. New evidence suggests that Bennu was born where material from the inner and outer Solar System mixed, with Jupiter playing a surprising role in shaping its formation.
Syracuse University wants you to know its Center for the Creator Economy means business
Syracuse University hosted its second annual 'Cuse Creator Con, highlighting content creation as a multi-billion dollar industry.
Republican billionaire Rick Jackson is walking a Trump tightrope in his quest to lead Georgia
Rick Jackson wants to be Georgia's governor and the Republican billionaire is promising to fight for working-class voters.
Detroit Lions updated depth chart: Week 7 vs. Packers
An updated look at the 2026 Detroit Lions’ depth chart ahead of their Week 7 game vs. the Green Bay Packers.
The boss whose twice-bust business appears to be back despite £3m debts
Andrew Woosnam took millions from his companies before leaving creditors including HMRC out of pocket
The Private Equity Playbook Most Small Business Owners Never Get Access To
What does the $650 billion wave of private equity capital moving into Main Street mean for owners who are unprepared for acquisition?
Gov. Newsom backs Lurie's reform measures
$13.5 million backs "Clean Up City Hall" propositions.
Inside Victoria's Secret's $6 billion business turnaround
Victoria's Secret is in the midst of a comeback, with sales surging and its stock on track to notch its best year ever.
Alaska Native Communities Get $375K for Health and Wellness
The SouthEast Alaska Regional Health Consortium (SEARHC) is investing $375,000 in funding to each of its 15 tribal partners to support public health in their respective communities. The funding will be distributed through SEARHC’s Healthy is Here program. Launched in 2017, the program has dedicated more than $3 million to locally driven wellness initiatives, including […]
14-year-old entrepreneur’s slim business reaches millions online
A 14-year-old entrepreneur’s slime business has reached millions online and gained 21,000 followers in 23 days.
AP Exclusive: Trump’s border chief defends wall plans in Texas’ Big Bend despite a court setback
The Trump administration's top border official is defending plans to build a wall in Texas' Big Bend region. Customs and Border Protection Commissioner Rodney Scott argues the entire $46 billion
‘Once we lose these, they’re gone forever’: What will become of the dioramas at the Academy of Natural Sciences?
The museum’s closure could endanger the 32 dioramas. Moving them can cost millions.
INTERVIEW | England call-up Charlie Cresswell’s ‘biggest dream’
Charlie Cresswell (24) has said that earning a call-up to England’s senior team is his “biggest dream”. The Stade Rennais defender had been a regular for the Three Lions at U21 level, but has ye...
Milligan Unveils New Ballad Health Simulation Lab on Campus
MILLIGAN, Tenn. (Oct. 23, 2026) — Today, Milligan University unveiled the campus’s new Ballad Health Simulation Lab to kick off Homecoming Weekend. Thanks to a generous $1 million gift from Ballad […]
NFL Week 7 expert picks, score predictions: Packers at Lions
Green Bay Packers vs. Detroit Lions NFL Week 7 expert picks from the Pride of Detroit staff.
3 bonds are on the California ballot. Here's a last-minute voter guide to make sense of them
Californians will decide on $44 billion in bonds when the vote on Propositions 1, 37 and 38. They'd take out debt to pay for housing and medical research.
Omaha Tribe opens $8.5M water treatment plant, quadrupling capacity
The Omaha Tribe of Nebraska has opened the Umóⁿhoⁿ Ní Waxúbe — Omaha Sacred Water Treatment Facility, Ní Ti, an $8.5 million plant that quadruples water storage capacity, according to utility director Jerry Henscheid. The facility came online Oct. 6 on the Omaha Reservation in northeastern Nebraska, replacing a plant built in 1980 that had […]
New Mexico lawmakers mull budget hike, eligibility limits for healthcare fund
The fund’s outlook has improved. It’s projected to have a $177 million surplus by fiscal year 2028, rather than a $30 million deficit.
Billionaires pour millions into San Francisco politics and elections
Millions of dollars have poured into San Francisco elections this campaign season, funding a torrent of postcards, pamphlets and video ads inundating voters’ mailboxes and screens.
Multimillion-dollar Pasco attractions business sends in the (creepy) clowns
Benjamin Nagengast turned his teenage paintball hobby into a family-owned attractions company that generates tens of millions of dollars a year.
Chesterfield apartments sell for $107.7M, a per-unit record
Bainbridge Midlothian, a 310-unit apartment complex in Chesterfield County, sold for $107.7 million, likely setting a Richmond price record.
Hila and Ethan Klein have made content together since 2011. Now she says he cheated for months.
Hila Klein, who started a YouTube channel with her husband in 2011 that now has 5.4 million subscribers, posted a lengthy statement on Instagram about the alleged affair.
How LaLiga Turned a Global Soccer Brand Into an $87 Million U.S. Business
LaLiga’s successful expansion into North America shows how to turn a global sports brand into a sustainable business.
Business briefs: Harry Reid airport completes $71 million baggage upgrade
In Terminal 1, the work included upgrades to eight baggage carousels, replacement of eight others, new conveyors and new carousel columns with LED screens. In Terminal 3, the project upgraded the computer hardware and software that control the baggage system …
As Florida governor’s race tightens, Ken Griffin gives another $5 million to Donalds
Ken Griffin said: “The people of Florida deserve leaders who wake up every day thinking about how to make their lives better.”
Selena Gomez's vaping admission highlights hidden health risks doctors say millions face daily
Selena Gomez called vaping "stupid" after it altered her voice, but doctors warn the health risks go beyond vocal cord damage for millions.
Intermountain Health Receives One of the Nation’s Largest Gifts in Pediatric Care
LAS VEGAS — Intermountain Foundation announced today that Nevada’s first stand-alone children’s hospital will be named Intermountain Health Felicia and Ben Horowitz Children’s Hospital in honor of a historic $150 million commitment. Felicia Horowitz, president of the Horowitz Family Foundation and co-founder and president of The Paid ...
Marijuana legalization tied to rise in heart hospitalizations, study finds
A study of 50 million hospital records found heart-related admissions rose faster after recreational marijuana sales became legal in 13 Western states.
Can millions of people live on the moon? These scientists say yes — but not for very long
Billionaires like Elon Musk and Jeff Bezos are claiming that we can expect big cities with millions of people on the moon, but a new study found that that may not be possible, so don’t start packing just yet.
Detroit Lions vs. Packers: Where to watch, TV channel, time
The Detroit Lions welcome in the Green Bay Packers for a pivotal Week 7 game. Here's where to watch, including TV channel and kickoff time.
AP Exclusive: Trump’s border chief defends wall plans in Texas’ Big Bend despite a court setback
The Trump administration's top border official is defending plans to build a wall in Texas' Big Bend region. Customs and Border Protection Commissioner Rodney Scott argues the entire $46 billion
Could Yuki Matsui Leave Padres in Free Agency?
After signing a five-year, $28 million deal with the San Diego Padres ahead of the 2024 season, Yuki Matsui has finally matured into the elite left-handed reliever that the Friars envisioned he'd be. Matsui was incredible for San Diego out of the bullpen, leading to questions surrounding his free agency status for the offseason. The …
CVS Health (CVS) Stock May Be Undervalued Despite Opioid Settlement
CVS Health has delivered solid gains over the past few years, and recent headlines have kept the company firmly in focus. With the stock around US$93, the question for you is whether that price is well supported by the earnings CVS generates today. Over the past 3 years CVS Health has returned 57.9%, which puts real weight on whether current earnings can shoulder the higher valuation investors are now paying. The US$315 million opioid settlement and related compliance upgrades may affect...
Netflix’s Leadership Shake Up…Explained
(Welcome to the “Most Important Story of the Week”, my bi-weekly strategy column analyzing the most important (but often not buzziest) news story of the last two weeks. I’m the Entertainment Strategy Guy, a former streaming executive who now analyzes business strategy in the entertainment industry. Please subscribe.) Well, I had a simple article planned for this week. Called “Whoa, I Missed It!”, I’d take a gander at a few important-but-under-the-radar stories I didn’t cover while I wrote about all things “Skydance. (Formerly known as “the saga of Netflix trying to buy Warner Bros., but not Discovery, then Paramount-Skydance bought all of Warner Bros. Discovery”.) Alas, that article will have to wait. Netflix made news. Ironically, my “Whoa, I Missed It!” article would have mostly been about “content” strategy decisions, which is also what today’s article is about. But instead of the entire industry, this article will only cover Netflix’s decision to upend their film and TV content teams. Just that! So that’s the full topic of the day. I’m going to tackle the issue in the opposite direction of the way “stuff” flows: uphill. We’ll start at film, then move onto TV, and then onto the CEOs themselves, and the strategy questions that still remain. But we start with the numbers driving this. Let’s dive in. Subscribe Most Important Story of the Week - Netflix Upends Their Corporate Hierarchy I’ve got a lot of thoughts, but we’ll start with the most common response to yesterday’s article. Let’s Talk Stock Price More than one person, responding to what I published two days ago, pointed out that, well, actually, the thing driving Netflix’s actions is this: In short, stock price! Even if Netflix isn’t obsessed with their own share price—they probably are, but, for the record, my strategic advice to every CEO is to absolutely ignore stock prices, which will, ironically, probably help the stock price long-term—most everyone thinks they are. By the way, I prefer market capitalization to stock prices, because it’s a more apples-to-apples way to compare companies: But there’s an even better way to look at it, and it kinda casts some doubt on the entire push here: price-to-earnings. I have a long list of articles that I wish I had written, and chief among them is an article titled, “Am I Still a Netflix ‘Bear’?” meaning someone who thinks Netflix’s stock is overvalued. As of last summer, Netflix had solved their biggest problem—which for me (circa 2019) was the lack of free cash flow—but their stock was CRAZY overvalued. That’s this chart here: Why did Netflix’s stock price increase to a price-to-earnings ratio of 50 last summer? What financial metric changed so quickly? Nothing. Given that, historically, mature entertainment companies average 10 to 20, with 16 being the average, that increase made little sense. Netflix’s stock swoon these last eight or so months wasn’t irrational; the stock price rise last year was. So if you want a really hot Netflix take, here it is: Netflix’s stock price has been going down because the financial industry recovered its senses, not because of any strategic mistake. Yes, that would imply that cleaning house may have been a mistake. That’s why the charts yesterday are so important, because they show that Netflix did have a strategic problem (a lack of hits) and that’s what they moved to address. (One could also argue the industry drastically overrated Netflix’s growth prospects, but that’s a financial industry problem, not a Netflix strategy problem per se. Some growth estimates are just crazy. *cough* AI *cough*) Now, the last time Netflix’s stock price crashed—circa 2022—it gave them an opening. I’d argue Netflix insiders knew they needed to expand post-COVID-19 crisis, adding advertising, cracking down on password sharing, and dabbling in sports. But if they had done that when their stock price was high, it would give folks a reason to second guess their strategy. (Arguably, last year, when Netflix pursued the Warner Bros. merger, it gave the industry a chance to review their business.) Instead, after the 2022 fall, they had the opening to make strategic changes. We may see Netflix pivot again following this latest slide. For example, the “binge versus weekly” conversation is alive and well again. Same for expanding into theaters even more. And adding both linear channels and streaming bundles. And maybe more either social, user-generated, vertical, or creator content. But the first shift came with who is making the content calls. A Message from Our Sponsor Last winter Pulp Fiction was on Netflix. For those same 90 days, it was also free, with ads, on Pluto TV and the Roku Channel. That is not a glitch, and it is not rare. The title has run on 20 different US streaming services since 2019, across 80 separate windows, and for more than 600 of those days it sat on a paid subscription service and a free ad-supported one at the same time. Almost nobody can see this, because when a title leaves a service, the record that it was ever there tends to leave with it. Reelgood keeps that record, dated to the day rather than the month: 4MM+ movie, show and episode titles across 300+ services globally, with timestamped arrivals, departures and moves across SVOD, AVOD, TVOD and vMVPD. Licensing teams price against every prior window. Rights teams check what a licensee actually delivered, and when. Pick a title you think you know: data.reelgood.com/title-availability Film - Dan Lin Want to know why I don’t opine on individual film or TV executives, especially new hires? Dan Lin. As I always caution, it’s really, really, really tough to predict which executives will succeed in new roles and which won’t. The successful head of co-production/finance partner, Rideback, Lin was considered for the head of DC Studios job before taking the job as the head of Netflix. By all accounts at the time, this was a smart hire. (That’s my read of the news coverage anyways.) But now that Netflix has fired Dan Lin, we got a slew of news stories about how he was doing a terrible job. In sports media, Bryan Curtis, new Substack writer/podcaster from The Ringer, calls this the “now you tell us” story, when you only hear the bad news after a star athlete leaves a sports team. In this case, now they tell us that Dan Lin was bad with talent after he got kicked out the door. So was Dan Lin a flop? It’s actually tough to say. While film moves faster than TV, even two years isn’t really enough time to evaluate a person’s output. The new head hasn’t really taken control. As Emily Horgan noted, it takes much longer than two years to produce animated films, so yeah, it’s definitely too early to judge in that domain. As for live-action films, I just published an article by Brandon Katz called “Netflix’s Summer of Bummer”, but I’d point out Netflix had a bad summer two years ago too. Arguably, their best summer came from KPop Demon Hunters last year and Happy Gilmore 2, the latter of which I saw credited to Lin. Then, the stories came out that Dan Lin clashed with talent, both Ben Affleck and Greta Gerwig, classic “now they tell us” factoids to explain his firing. This may have been true, but also should have been expected given that he was given the mandate to bring budgets back in check, especially after Rebel Moon. So if he made folks upset, well, that’s what he was hired to do! But also, he was described as “well-liked” at his hiring! In that case, I’m a bit sympathetic to Lin, since he may have been undercut by senior leadership, as often happens. Basically, a CEO hires a subordinate to be their “bad cop” and keep budgets in check, but then when talent complains, the CEO ends up undercutting them. That’s how I think you end up with a Narnia movie as expensive as any of the other flops, along with a film executive the town no longer likes. As a result, I think that Netflix is now executing a classic “hire the opposite” move by hiring Peter Rice. This phrase comes from my experience following football and basketball coaching decisions, where teams generally hire the opposite of who they just had. If you have an offense-minded head coach, hire the defensive guy. Or in college football, if you have a strong recruiter, then you pivot to an “X’s and Os” type of guy. Or in pro basketball, if you have a very analytically minded coach, you hire the player-friendly guy. I see that here. After dropping Scott Stuber—arguably a talent-friendly executive with lax budget control—Netflix hired the business guy to keep costs in check. Now Netflix is pivoting back to Peter Rice and presumably a more talent-friendly regime. (Disney, by the way, has done this twice: hiring business guys to succeed talent-friendly Bob Iger. It didn’t work out last time.) When it comes to Peter Rice…we’ll see! Maybe he works out, but maybe he doesn’t. I’d actually say the biggest problem is that Netflix still hasn’t solved its “IP Problem”, in that they don’t own much IP, so they just have a lower hit rate. The new executive won’t solve that. (Though buying Lionsgate would help.) Share “Content” - Bela Bajaria I almost published yesterday’s article after this column, but ended up flipping the order, because it told the story so well. So if you want the data for why Netflix is looking at TV to fix their problems, it’s in that article, this graph in particular: I know I just wrote that it’s often hard to judge executives, but Bajaria ran TV for six years and film for three and a half more. That’s more than enough to judge hit rates, and Netflix needs more hits. That’s the story. Since 2023, Netflix hasn’t had as many hit shows as it used to, and many of its previous power house TV shows have ended their runs (Stranger Things most of all). Also, many shows from 2020 to 2022 probably pre-dated Bajaria’s tenure. (That said, one thing may have been outside of Bajaria’s control, which I explain below.) Let’s lump some content strategy thoughts about Netflix and TV into one place: We’re just getting started with this issue, but the rest is for paid subscribers of the Entertainment Strategy Guy, so if you’d like to find out… Why I partially blame Squid Game for Netflix’s latest troubles… What is “the football trap”... Why it might not be the TV shows or films’ fault at all… What change I don’t think Netflix will make... How Bela Bajaria evolved Netflix’s TV strategy in smart ways… Whose departure likely submarined Bajaria’s final few years… One sneaky explanation for Netflix’s content struggles... And a whole lot more... ...please subscribe! We can only keep doing this great work with your support.
Mark Walter borrowed from Chicago firm with investigators circling
Amistad Financial Group, a holding company that counts Magic Johnson as a minority owner, loaned about $1.26 billion to Walter’s companies between March and June of this year.
Fargo couple plans to relocate Stabo to former Swanson Health building
Matt and Lindsey Lee are buying the $1.5 million Hancock Building and adjoining Douglass Building in the heart of Fargo.
Sportsbooks, Prediction Markets Set Records for Political Spending
Sportsbooks routed more than $80 million through a super PAC as the AGA and Kalshi stepped up lobbying in a fight over prediction markets.
Business pioneer Loida Lewis on leadership, Filipino American representation
In 1974, Lewis became the first Asian and Filipino woman to pass the New York bar without attending a U.S. law school and ran a multinational, billion-dollar company.
NY state grant helps Waverly business Soprano's Market get facelift
A $4.5 million NY Forward award helped fund a more than $700,000 renovation project at Soprano's Market in Waverly.
He Took Big Risks to Make Billions. He Wants Georgia Voters to Bet on Him.
Rick Jackson’s run for governor as a political nobody was his latest gamble. The campaign has brought scrutiny to the businesses that made him a fortune.
Big Ten staff picks for Week 8
The staff of Nittany Lions Wire shares its picks for this weekend's Big Ten action.
Netflix reportedly offered Microsoft $500 million to license Xbox games for adaptations.
Xbox CEO Asha Sharma and team countered by asking for $800 million, and Netflix has pulled its offer, Puck reports in an article discussing the new leadership at Netflix. Xbox launched an “XP” division this month that will work on adaptations of its games, and Xbox is already working with Netflix on a Diablo animated series. [Link: The Peter Rice Playbook & Elon's Skydance Motive | https://puck.news/newsletter_content/what-im-hearing-the-peter-rice-playbook-elons-skydance-motive/ | Puck]
Green Bay Packers vs. Detroit Lions: How to watch the NFL Week 7 game, channel, streaming info and more
Susanville tribal businesses sue SBA, alleging suspensions cost nearly $130M in contracts
Businesses owned by the Susanville Indian Rancheria sued the Small Business Administration on Oct. 22, accusing the agency of a “brazen abuse of government power” that cost them nearly $130 million in federal contracts and cut off revenue supporting the Northern California tribe. The tribe’s ATI Government Solutions LLC federal contracting business, along with six […]
Miami's Israeli gold rush: Michelin-starred restaurants, billion-dollar deals and booming businesses
From a Michelin-starred kosher restaurant and Eyal Shani's growing presence to massive real estate deals, Israeli businesses are flourishing in Miami; but soaring costs, bureaucracy and distance from family are testing the American dream
How to watch Lions vs. Packers: TV, streaming, radio, more
TV, online streaming, announcer, and kickoff time information for Detroit Lions vs. Green Bay Packers.
Browns sign Maliek Collins to $30 million extension
The Cleveland Browns have secured one of their standout defensive players for the future before their next game against the Tennessee Titans . Cleveland defensive tackle Maliek Collins has agreed to a two-year contract extension worth $30 million. According to NFL insider Ian Rapoport, Collins’ agent, Drew Rosenhaus, confirmed the agreement to him […] The post Browns sign Maliek Collins to $30 million extension appeared first on ClutchPoints.
'Supercharging bras': The story behind Victoria's Secret's $6 billion business turnaround
Victoria's Secret is in the midst of a historic comeback, with sales surging and its stock on track to notch its best-ever year. What gives? https://bit.ly/4BhD84S
In Arkansas, Democrats see an opening at the edge of the competitive midterms map
In a sign of the potentially dire midterm political environment, Republicans have spent millions of dollars playing defense in Arkansas, one of the most conservative states in the country.
Washington Post
Elon Musk has cemented his record as the largest individual political donor in modern American history. Musk poured $446 million of his own money into this year’s midterm elections, mostly aimed at...
Three giant black holes discovered in a galaxy from the dawn of time
Astronomers have discovered three actively feeding black holes inside a single galaxy more than 12.5 billion light-years away, revealing a remarkable scene from the universe’s infancy. Two of the black holes are separated by just 620 light-years and are expected to eventually merge, while a third lurks farther away. One weighs an astonishing 80 million suns, and another is growing faster than conventional theories predict.
Q+A: How this private equity group raised $1.3 billion investing in fr
Doug Kennealey, co-founder of Princeton Equity Group, said franchises are "phenomenal" and "cash-rich" business models. The firm secured $1.3 billion in two months for its most recent fund.
Country music’s richest singer has a stunning net worth of more than $1 billion
You might be surprised to learn who has the biggest bank account.
Rappahannock General Hospital to get $73.3M in upgrades
Bon Secours Mercy Health plans a $73.3 million investment in Rappahannock General Hospital, with renovations and new construction.
What Californians should know about Prop. 42
The measure could block the billionaire tax — and more.
Peter Thiel says Apple has done 'nothing new' post Steve Jobs
The billionaire venture capitalist said eccentric CEOs like Elon Musk "are way better for society" than Apple Chairman Tim Cook.
Oakland County business accused of making false statements to obtain federal loan agrees to $1M+ settlement
A Wixom, Michigan, business accused of making false statements to obtain a loan it was ineligible for has agreed to pay a settlement of just over $1.5 million after it was sued by the federal government, according to the Department of Justice.
Money is everywhere in politics. Here’s how to see who’s funding your candidates.
Follow our illustrated guide to learn how to find corporate contributions, see obscure multi-million dollar donations and link that money to big donors.
Lions Pass Rush Must Make Jordan Love Uncomfortable Sunday
A Lions insider says Green Bay hunts big plays more than anyone, and Detroit's answer starts up front. #OnePride
Next stop: Detroit
The Packers departed Green Bay's Austin Straubel International Airport on Saturday, Oct. 24, 2026, for their Week 7 matchup against the Detroit Lions.
He Took Big Risks to Make Billions. He Wants Georgia Voters to Bet on Him.
Rick Jackson’s run for governor as a political nobody was his latest gamble. The campaign has brought scrutiny to the businesses that made him a fortune.
ESMO: Roche touts ‘convincing’ phase 3 KRAS data after win over rivals
Roche has shed more light on its investigational KRAS G12C inhibitor's phase 3 victory over Amgen’s Lumakras and Bristol Myers Squibb’s Krazati. The open-label Krascendo 1 trial enrolled 338 people with previously treated KRAS G12C-mutated non-small cell lung cancer (NSCLC). Patients who had already received a KRAS G12C inhibitor or pan-KRAS/RAS inhibitor were excluded from the trial. Participants received either divarasib once daily, Lumakras once daily or Krazati twice daily. Roche announced back in July that divarasib had demonstrated statistically significant improvements in progression-free survival (PFS) and overall survival (OS), meeting the trial’s primary and key secondary endpoints. But the Swiss pharma had been holding back the detailed data until now. At the European Society for Medical Oncology (ESMO) Congress in Madrid, Roche revealed that median OS for the 167 patients who received divarasib was 17.7 months, compared to 12 months for the 171 patients who received Lumakras or Krazati. The benefit was similarly clear when it came to median PFS, which stood at 9.8 months versus 5.7 months, respectively. A total of 44% of patients receiving divarasib were alive without disease progression at one year, compared to 24% of the control group, according to Roche’s presentation. It was a similar story for the objective response rate, which came in at 58% for divarasib versus 32% for the control group, while median duration of response was 11.9 months versus 6.9 months. Stefan Frings, M.D., Ph.D., deputy chief medical officer at Roche Pharma, told Fierce that the data made for a “very comprehensive, strong package, which should be convincing to health authorities.” “It’s an important advance for patients with lung cancer,” Frings said in an interview at a Madrid hotel during the conference. “It's a second-line setting, and patients who receive divarasib benefit compared to the current first-generation KRAS G12C inhibitors by having far longer overall survival,” he continued. “They live longer. They have better progression-free survival, better response rates, and with a safety profile which is—if [anything]—even better,” he said. According to Roche, 4.8% of patients receiving divarasib discontinued treatment due to treatment-related adverse events, compared to 11.7% in the control group. Serious treatment-related adverse events were also less common with divarasib, at 7.8% versus 15.2%. Roche’s confidence in divarasib had been building even before this phase 3 success. The candidate had already shown better potency and selectivity than the incumbent KRAS G12C inhibitors Krazati and Lumakras in preclinical tests. After cross-trial comparisons suggested that the edge translated into better clinical outcomes, Roche axed a study comparing divarasib to the chemotherapy docetaxel and went toe-to-toe with Lumakras and Krazati. “We designed the drug on purpose with higher potency and better selectivity,” Frings explained. “So, based on preclinical models, we clearly knew it would be superior to the first generation.” “It’s honestly not so frequent that pharma companies go head-to-head,” he added. “But if you want to make a point, if you want to convince payers, prescribers and patients … then a head-to-head win is rather rewarding.” While Amgen and BMS reached the regulatory finish line first for KRAS G12C-mutated, locally advanced or metastatic NSCLC in 2021 and 2022, respectively, they have struggled to capitalize on their head start. Krazati brought in $55 million for BMS in the second quarter, while Lumakras delivered $111 million to Amgen. For its part, Roche is aiming for peak divarasib sales of 1 billion to 2 billion Swiss francs ($1.2 billion to $2.5 billion), according to Frings. The Big Pharma is currently recruiting patients into a phase 3 trial comparing divarasib plus Keytruda against Keytruda plus chemotherapy in previously untreated advanced or metastatic nonsquamous KRAS G12C-mutated NSCLC. Roche has previously suggested that sales in metastatic disease would account for most of the forecast. Frings was tight-lipped on the exact timeline for a regulatory filing but said the Swiss pharma is “certainly keen to get this to as many patients as possible around the world.” Roche has more RAS drugs coming up behind divarasib. The pharma has already launched phase 1 trials of a pan-RAS inhibitor called RG6505 and a KRAS G12D inhibitor dubbed RG6620 in solid tumors. Roche’s partner Chugai Pharmaceutical is also testing a pan-KRAS inhibitor called AUBE00. Roche has made a “deliberate effort” to test a range of RAS drugs, Frings said. “If you have many rare mutations and you are scrambling to find sufficient patients, a pan-RAS inhibitor makes a lot of sense,” he explained.
Yankees Should Probably Avoid Massive $90 Million Risk
The New York Yankees probably shouldn't go down this road.
DOE expands tribal energy funding to $125M, selects 63 projects
The Department of Energy expanded a $50 million tribal energy funding opportunity to more than $125 million after tribal applications sought roughly 10 times the initial amount. The agency selected 63 tribe-led projects across 16 states for what it described as the largest single investment in the Office of Indian Energy’s history. The projects include […]
Instacart Stock What Health Benefits Deal And $5 Million Settlement Mean
Instacart parent Maplebear has agreed to a US$5,000,000 settlement with U.S. authorities over past PERM hiring practices and has been selected by True Rx Health Strategists to power an employer funded healthy food benefit through Instacart Health Fresh Funds starting in 2027. The True Rx program positions Instacart within pharmacy benefit design and ties employer spend directly to clinically supervised food choices. The settlement adds compliance obligations, policy changes and monitoring...
What should become a Detroit Lions tradition at Ford Field?
What fourth quarter tradition would best fit the Detroit Lions?
How Braves should handle $42 million Jurickson Profar situation
This could be one solution for the Braves.
A hidden bias in human language challenges 70 years of science
A groundbreaking study challenges 70 years of assumptions about how human language works. By analyzing billions of word uses, scientists discovered that meaning is organized around power, danger, and order rather than emotion alone. Even more surprisingly, human language shows a powerful hidden preference for safety, suggesting that our words may reflect ancient survival instincts.
Why did humans' brains surpass chimps'? A tiny foe might help explain it
A viral infection from millions of years ago may have influenced chimp brain evolution through DNA leftovers in the genome.
Auburn University opens $224 million STEM+Ag science complex
Largest research construction project in school's history completed after six years of planning
Packers Lose Defensive Captain Just Before Massive Showdown With Lions
Green Bay Packers defensive captain Zaire Franklin has been ruled out against the Detroit Lions, leaving Green Bay without both starting linebackers.
Guest Commentary: How anti-Muslim politics endangers every Floridian
The political caricature of Muslims as a national security threat bears little resemblance to the reality that Floridians are living, working, and raising families in peace with nearly half a million Muslims woven into the fabric of the state.
Lions vs. Packers: 3 Best Player Prop Bets for Sunday's Showdown
The Lions and Packers bring explosive offenses into Sunday's divisional showdown. I'm 10–8 on the season and targeting three player props to cash at Ford Field.
Crushed between diamonds, ice changes shape, a clue to what lies inside Neptune
Physicists squeezed water to about 35 million PSI and saw its atoms rearrange into a less orderly pattern, a clue to Uranus and Neptune.
Brian Branch set to make season debut in Week 7
Lions S Brian Branch will make his 2026 debut as the team is expected to activate him from PUP
Capcom Confirms Data Breach That Affected 11.7 Million Users
Capcom ID is still available to use, but users may see more phishing scam emails.
Child-led citizen science helps Ecuadorian community tackle beach pollution and shape environmental decisions
Pollution from human-generated waste in marine ecosystems has reached critical levels, with cigarette butts (CBs) among the most persistent and harmful pollutants. Globally, an estimated 4.5 trillion ...
New evidence suggests spinosaurus spent most of its life underwater
Millions of years after animals first conquered land, some took an extraordinary evolutionary U-turn and returned to the water. Using machine learning and thousands of fossil measurements, Yale scientists have uncovered surprising clues about which prehistoric creatures truly became aquatic. Their findings suggest that Spinosaurus spent most of its life underwater, while some ancient marine reptiles previously thought to be fully aquatic actually spent considerable time on land.
Cubs Have Easy Decision To Make About Jacob Webb
Coming off another dominant season as a reliable high-leverage arm, the veteran right-hander’s affordable $2.5 million club option makes retaining him a clear-cut choice for Chicago's bullpen.
Republican billionaire Rick Jackson is walking a Trump tightrope in his quest to lead Georgia
Jackson’s path differs from Donald Trump’s, and the 72-year-old healthcare magnate and investor brings a vastly different persona to his first campaign. Unlike Trump, who was born to wealth, Jackson spent his early years bouncing through foster homes before launching his first company as a young man.
Xbox Asked for $800 Million After Netflix Offered $500 Million for Game Adaptation Rights
Netflix offered Xbox $500 million for seven years of exclusive film and TV rights, and Xbox countered with $800 million, Puck's newsletter…
Television Q&A: How are TV ratings tracked in the age of str...
Nielsen now combines viewer panels with data from millions of TV devices to track audiences across cable and streaming, while a TV Q&A also tackles wildlife-fil...
University of Scranton awarded nearly $5.5 million NASA grant for space science education
FOX56 WOLF TV carries news, sports, weather and coverage of local events in the Wilkes-Barre, Pennsylvania area, including Mountain Top, Plymouth, Nanticoke, Kingston, Back Mountain, Scranton, Moosic, Pittston, Avoca, Edwardsville, Hilldale, Wyoming, Laflin, Yatesville, Pittston, Dupont, Sugar Notch, Korn Krest, Warrior Run and Larksville.
Xbox Reportedly Asked Netflix for $800 Million for 7-Year Movie and TV Exclusivity Deal
Xbox reportedly asked Netflix for $800 million for a seven-year deal that would have given the streamer exclusive adaptations based on its games.
Seahawks Get Strong Trade Deadline Take on Lions’ Sam LaPorta
The Seattle Seahawks have their go-to star for their passing game in Jaxon Smith-Njigba, but could they potentially pursue another pass-catching weapon to pair with the wideout? While there are concerns about the team’s running game, those worries can go away with Zach Charbonnet and Jadarian Price returning from injury. Nonetheless, Seattle has lost Elijah […] The post Seahawks Get Strong Trade Deadline Take on Lions’ Sam LaPorta appeared first on HEAVY.
South Bend teen’s slime business racks up 21,500 followers and 6.1M views in 23 days
A 14-year-old South Bend-area entrepreneur has gained more than 21,500 Facebook followers and 6.1 million video views in just 23 days with her slime and squishy
Detroit Lions Announce Decision on Brian Branch, Cade Mays
The Detroit Lions officially activated Brian Branch and Cade Mays ahead of Sunday's Week 7 showdown against the Green Bay Packers.
Tickets on sale now for 49 Winchester's Charlottesville show next year
49 Winchester, a homegrown Virginia country rock band, is the first band announced for Ting Pavilion's 2027 lineup. Tickets are on sale now.
Coyer Candle Co. nears $1 million raised for community groups
Coyer Candle Co., owned by Scott and Lisa Coyer, produces clean-burning candles with 100% soy wax and cotton wicks.
Is the WA ‘millionaires tax’ really coming for public pensions?
SEATTLE — When you think about the mansion- and yacht-owning millionaire crowd, retired schoolteachers don't typically leap to mind. Nevertheless, foes of Washington's new high-earner income tax are making a
Blazers' Portland Future Gets Messy as Arena Deadline Closes In
A billion-dollar maintenance dispute and conflicting lease demands jeopardize a massive Moda Center renovation, leaving the franchise’s long-term stability in doubt as a critical state funding deadline looms.
Penn State men's basketball player profile: Jay Rodgers, Guard
Penn State basketball is getting ready to take the court once again, so here’s a look at new guard Jay Rodgers.
Year one, $200 million funding of North Dakota’s Rural Health Transformation Program allocated
Year one allocations for North Dakota’s Rural Health Transformation Program (RHTP) have been submitted to the Centers for Medicare & Medicaid Services (CMS), according to Director of Rural Health Transformation Krissie Mayer.
Titans $74 Million WR Tabbed Trade Candidate Before Week 7
A member of the Tennessee Titans wide receiver room is tabbed as a potential trade candidate by an NFL writer The post Titans $74 Million WR Tabbed Trade Candidate Before Week 7 appeared first on HEAVY.
Evander hits Messi-esque levels of production for FC Cincinnati
By Jaime UribarriIs Evander the best player in Major League Soccer not named Lionel Messi?FC Cincinnati’s All-Star Brazilian playmaker has looked the part throughout his MLS career and further stren...