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SheMed Built a $1 Billion Business on GLP-1s. Its Next Bet Goes Beyond Weight Loss
SheMed’s study of more than 8,000 women found improvements in weight, blood sugar, and cholesterol. Its founders believe that’s just the start of what GLP-1 research could uncover.
Two Year Lifestyle Program Improves Heart Markers Without Weight Loss
A two-year European community program shows diet and activity changes can improve cholesterol, blood sugar and waist size even without dropping pounds.
Healthy living takes center stage at Methodist Hospitals’ annual free fall community health fair
St. Timothy Community Church in Gary welcomed attendees to Methodist Hospitals’ annual Free Fall Community Health Fair on Saturday, October 17. This event is hosted every year by Methodist Hospitals to provide free screenings, such as blood glucose and cholesterol tests, as well as heart attack and stroke risk assessments and other resources to the … Continued
Choctaw Nation opens third small business center in McAlester
The Choctaw Nation of Oklahoma has opened a small business center inside the renovated McAlester Public Library, expanding access to workspace, business advising and connections to lenders. The Chahtapreneur Business Center’s 3,500-square-foot McAlester location is the tribe’s third center under the tribe’s purview, joining existing locations in Durant and Idabel, according to a tribal news […]
Scientists finally uncover why statins can cause muscle pain
Scientists have uncovered a surprising reason why statins, the widely prescribed cholesterol-lowering drugs that help prevent heart attacks and strokes, can sometimes cause muscle pain, weakness, and even severe muscle damage. Using advanced imaging technology, researchers discovered that statins can attach to a crucial protein in muscle cells and force open a channel that normally controls calcium flow. This causes calcium to leak continuously, potentially damaging muscle tissue.
Choctaw Nation opens third small-business center in McAlester
The Choctaw Nation opened its third Chahtapreneur Business Center in McAlester, offering entrepreneurs workspace and small-business support.
HOMETOWN HEALTH: Managing high blood pressure could save half a million lives worldwide, health experts say
Researchers recommend expanding treatment for high blood pressure and expanding access to cholesterol-lowering statin medications.
Iowa Football: Tim Lester's Thoughts On The Quarterback Room
Lester wouldn't say if Iowa would go back to a rotation between Jeremy Hecklinski and Hank Brown, but he's confident the Hawkeyes can win games with either of them.
What Happens to Your Cholesterol When You Eat Eggs Every Day
Eggs are high in cholesterol, and some studies raise concerns about them for people with high blood pressure. But research shows most people can eat them as part of a heart-healthy diet.
New Britain Public Library to Host "Health to Treat Spooktacular" for Halloween
The New Britain Public Library, in partnership with Access Health CT, is set to host, ” Health to Treat – a Spooktacular Day of Health Resources & Community Care” on Halloween. The event promises free food alongside “free professional health screenings, services & more!”. Services available are to include blood pressure checks, cholesterol screenings, blood […]
Study finds a whole grain sweet spot for heart health
You know that whole grains are good for your heart. New research identifies how much it takes to notice improvements in cholesterol, blood pressure and more.
Whole Fruits vs. Juice? Study Finds Differences in Heart Health
Whether you slice fruit into your cereal or drink a glass of juice apparently makes a difference for the heart. A large U.S. study shows that adults with high blood pressure, elevated cholesterol, or ...
Certilman Balin adds attorneys, healthcare practice
Certilman Balin Adler & Hyman has expanded by adding attorneys from Cooperman Lester Miller Gruber Kraus and establishing a new healthcare practice. The practice will advise healthcare providers and organizations on legal matters, enhancing the firm's multidisciplinary services across the region.
Here’s How Many Whole Grains To Eat in a Day To Boost Heart Health
In TODAY.com’s Expert Tip of the Day, researchers reveal how many daily servings of whole grains lead to weight loss, lower blood pressure and reduce cholesterol for a healthier heart.
9 Best Fruits to Help Reduce Blood Pressure, Cholesterol and Heart Disease Risk
The soluble fiber in fruit can improve cholesterol, a cardiologist says. Certain fruits show “potent cardiovascular protective action” thanks to their beneficial plant compounds.
MLB's CC Sabathia Shares Health Message, Talks Hall of Fame
MLB star CC Sabathia joins TODAY to share a message about the importance of understanding your cholesterol numbers and shares his own health scare. “I was pitching in the big leagues and had no idea I had this blockage and just got lucky enough to be able to catch it,” he says. He also opens up about being inducted into the Monument Park Hall of Fame at Yankee Stadium. “It means more than going into the Hall of Fame…To be able to come to the Bronx, put on the pinstripes and succeed here…feels great.”
China’s next-gen stealth fighters, bad cholesterol drug: 7 science highlights
From oil refining with reduced energy use to a self-powered neural device, here are some highlights from SCMP’s recent science reporting.
Scientists find the whole grain “sweet spot” for better heart health
Eating four to six servings of whole grains a day may deliver meaningful benefits for heart health, according to a large review of 87 clinical trials. Researchers found improvements in body weight, waist size, blood pressure, cholesterol, blood sugar, triglycerides, and some markers of inflammation.
What are statins? And can healthy people use them to prevent heart disease and dementia?
New evidence shows more people might benefit from this cholesterol-lowering medication than we previously thought. But that doesn’t mean everyone should take one.
Gut health scientist eats 30g of fiber daily: 3 go-to recipes
Beyond its reputation for aiding smooth digestion, fiber helps lower cholesterol levels and keep blood sugar levels balanced throughout the day.
Gut health scientist eats 30g of fiber daily: 3 go-to recipes
Beyond its reputation for aiding smooth digestion, fiber helps lower cholesterol levels and keep blood sugar levels balanced throughout the day.
UF Health Jacksonville mobile health unit targets barriers to healthcare
UF Health Jacksonville expects its mobile health unit will provide blood pressure, cholesterol and diabetes screenings and preventative services.
8 Daily Habits to Support Your Heart, Kidney and Metabolic Health
(Feature Impact) When it comes to protecting your heart, supporting your kidney function and improving your metabolic health, you’ll find the advice for each one looks similar. That’s because your body’s systems are deeply interconnected: what affects one will have ripple effects across the others.Cardiovascular-kidney-metabolic health, or CKM health, is a perfect example. When any one of these systems is compromised, it can lead to problems with the others. Therefore, it’s not uncommon for health problems like heart disease, stroke, diabetes and kidney disease to develop or worsen simultaneously – a condition collectively known as CKM syndrome.The reverse is also true, so habits that are healthy for your heart will have a positive effect on your kidneys and metabolic system and vice versa. Consider these simple strategies that align with the American Heart Association’s Life’s Essential 8, a list of healthy steps that can improve overall health. Learn more about how these habits and health measures affect your CKM health at Heart.org.Choose Healthy Foods – Food is your body’s fuel, so fill your tank wisely. Certain types of foods can help your blood pressure, cholesterol, blood glucose and triglycerides stay within healthy ranges, while poor nutrition can push those numbers into more dangerous territory. Focus on vegetables, fruits, whole grains, plant-based proteins (e.g. beans, legumes and nuts) and lean animal proteins (e.g. seafood, skinless poultry and low-fat dairy). Drink plenty of water throughout the day and limit added sugar and salty or fatty foods.Stay Physically Active – Exercise doesn’t have to feel like a chore – in fact, some of your favorite hobbies may already count. The American Heart Association recommends aiming for 150 minutes per week of moderate physical activity like dancing, gardening or walking, moving quickly enough to elevate your heart rate and break a light sweat. Alternatively, choose 75 weekly minutes of vigorous exercise that gets you breathing hard and fast; think running, swimming, playing tennis or riding your bike on hilly terrain.Avoid Nicotine – Tobacco and other nicotine products can raise your blood pressure, damage blood vessels and increase your risk of heart attack and stroke, which are all bad news for your CKM health. If you’re currently trying to quit, you aren’t alone, so don’t be afraid to seek out support groups and resources to help.#placement_976606_0_i{width:100%;max-width:550px;margin:0 auto;}var rnd = window.rnd || Math.floor(Math.random()*10e6);var pid976606 = window.pid976606 || rnd;var plc976606 = window.plc976606 || 0;var abkw = window.abkw || '';var absrc = 'https://ads.empowerlocal.co/adserve/;ID=181918;size=0x0;setID=976606;type=js;sw='+screen.width+';sh='+screen.height+';spr='+window.devicePixelRatio+';kw='+abkw+';pid='+pid976606+';place='+(plc976606++)+';rnd='+rnd+';click=CLICK_MACRO_PLACEHOLDER';var _absrc = absrc.split("type=js"); absrc = _absrc[0] + 'type=js;referrer=' + encodeURIComponent(document.location.href) + _absrc[1];document.write('');Prioritize Healthy Sleep – Sleep gives your body a chance to rest and recover from the day, but it’s often one of the first things people sacrifice when life gets busy. Poor sleep can increase your risk for heart disease, weight gain and other issues. Aim for a solid 7-9 hours a night. Keep your bedroom cool, dark and comfortable, and do your best to limit distractions like late-night smartphone scrolling.Watch Your Blood Pressure – When your blood pressure is high, it forces your heart to work harder to pump blood through the body, which can weaken it over time. It can also damage the delicate arteries in and around the kidneys, putting CKM health further at risk. Information is power, so check your blood pressure frequently to know whether further action is needed to keep it under control.Manage Your Blood Sugar – High blood sugar can damage the kidneys, eyes, blood vessels and more, thereby increasing your chance of developing harmful CKM conditions. Controlling blood sugar is particularly important for people with diabetes. If you don’t have diabetes and still experience frequent blood sugar spikes and crashes, talk to your doctor.Control Your Cholesterol – Cholesterol comes in both “bad” (LDL) and “good” (HDL) forms, requiring a balancing act to keep your levels within a healthy range. If LDL is high and HDL is low, your risk of clogged blood vessels, heart attack and stroke are higher. Healthy levels keep blood flowing to your heart and kidneys, supporting your metabolic health in the process. See your doctor for regular bloodwork so you can monitor cholesterol changes.Maintain a Healthy Weight – Since excess body weight puts pressure on the heart, kidneys and other organs, a healthy body weight helps lower your risk of CKM syndrome. Whether you’re hoping to maintain or reduce your weight, regular exercise, healthy eating and quality sleep are all great ways to achieve your goals.
8 Daily Habits to Support Your Heart, Kidney and Metabolic Health
(Feature Impact) When it comes to protecting your heart, supporting your kidney function and improving your metabolic health, you’ll find the advice for each one looks similar. That’s because your body’s systems are deeply interconnected: what affects one will have ripple effects across the others.#placement_1126610_0_i{width:100%;max-width:550px;margin:0 auto;}var rnd = window.rnd || Math.floor(Math.random()*10e6);var pid1126610 = window.pid1126610 || rnd;var plc1126610 = window.plc1126610 || 0;var abkw = window.abkw || '';var absrc = 'https://ads.empowerlocal.co/adserve/;ID=181918;size=0x0;setID=1126610;type=js;sw='+screen.width+';sh='+screen.height+';spr='+window.devicePixelRatio+';kw='+abkw+';pid='+pid1126610+';place='+(plc1126610++)+';rnd='+rnd+';click=CLICK_MACRO_PLACEHOLDER';var _absrc = absrc.split("type=js"); absrc = _absrc[0] + 'type=js;referrer=' + encodeURIComponent(document.location.href) + _absrc[1];document.write('');Cardiovascular-kidney-metabolic health, or CKM health, is a perfect example. When any one of these systems is compromised, it can lead to problems with the others. Therefore, it’s not uncommon for health problems like heart disease, stroke, diabetes and kidney disease to develop or worsen simultaneously – a condition collectively known as CKM syndrome.The reverse is also true, so habits that are healthy for your heart will have a positive effect on your kidneys and metabolic system and vice versa. Consider these simple strategies that align with the American Heart Association’s Life’s Essential 8, a list of healthy steps that can improve overall health. Learn more about how these habits and health measures affect your CKM health at Heart.org.Choose Healthy Foods – Food is your body’s fuel, so fill your tank wisely. Certain types of foods can help your blood pressure, cholesterol, blood glucose and triglycerides stay within healthy ranges, while poor nutrition can push those numbers into more dangerous territory. Focus on vegetables, fruits, whole grains, plant-based proteins (e.g. beans, legumes and nuts) and lean animal proteins (e.g. seafood, skinless poultry and low-fat dairy). Drink plenty of water throughout the day and limit added sugar and salty or fatty foods.Stay Physically Active – Exercise doesn’t have to feel like a chore – in fact, some of your favorite hobbies may already count. The American Heart Association recommends aiming for 150 minutes per week of moderate physical activity like dancing, gardening or walking, moving quickly enough to elevate your heart rate and break a light sweat. Alternatively, choose 75 weekly minutes of vigorous exercise that gets you breathing hard and fast; think running, swimming, playing tennis or riding your bike on hilly terrain.Avoid Nicotine – Tobacco and other nicotine products can raise your blood pressure, damage blood vessels and increase your risk of heart attack and stroke, which are all bad news for your CKM health. If you’re currently trying to quit, you aren’t alone, so don’t be afraid to seek out support groups and resources to help.Prioritize Healthy Sleep – Sleep gives your body a chance to rest and recover from the day, but it’s often one of the first things people sacrifice when life gets busy. Poor sleep can increase your risk for heart disease, weight gain and other issues. Aim for a solid 7-9 hours a night. Keep your bedroom cool, dark and comfortable, and do your best to limit distractions like late-night smartphone scrolling.Watch Your Blood Pressure – When your blood pressure is high, it forces your heart to work harder to pump blood through the body, which can weaken it over time. It can also damage the delicate arteries in and around the kidneys, putting CKM health further at risk. Information is power, so check your blood pressure frequently to know whether further action is needed to keep it under control.Manage Your Blood Sugar – High blood sugar can damage the kidneys, eyes, blood vessels and more, thereby increasing your chance of developing harmful CKM conditions. Controlling blood sugar is particularly important for people with diabetes. If you don’t have diabetes and still experience frequent blood sugar spikes and crashes, talk to your doctor.Control Your Cholesterol – Cholesterol comes in both “bad” (LDL) and “good” (HDL) forms, requiring a balancing act to keep your levels within a healthy range. If LDL is high and HDL is low, your risk of clogged blood vessels, heart attack and stroke are higher. Healthy levels keep blood flowing to your heart and kidneys, supporting your metabolic health in the process. See your doctor for regular bloodwork so you can monitor cholesterol changes.Maintain a Healthy Weight – Since excess body weight puts pressure on the heart, kidneys and other organs, a healthy body weight helps lower your risk of CKM syndrome. Whether you’re hoping to maintain or reduce your weight, regular exercise, healthy eating and quality sleep are all great ways to achieve your goals.
8 Daily Habits to Support Your Heart, Kidney and Metabolic Health
(Feature Impact) When it comes to protecting your heart, supporting your kidney function and improving your metabolic health, you’ll find the advice for each one looks similar. That’s because your body’s systems are deeply interconnected: what affects one will have ripple effects across the others.#placement_1126603_0_i{width:100%;max-width:550px;margin:0 auto;}var rnd = window.rnd || Math.floor(Math.random()*10e6);var pid1126603 = window.pid1126603 || rnd;var plc1126603 = window.plc1126603 || 0;var abkw = window.abkw || '';var absrc = 'https://ads.empowerlocal.co/adserve/;ID=181918;size=0x0;setID=1126603;type=js;sw='+screen.width+';sh='+screen.height+';spr='+window.devicePixelRatio+';kw='+abkw+';pid='+pid1126603+';place='+(plc1126603++)+';rnd='+rnd+';click=CLICK_MACRO_PLACEHOLDER';var _absrc = absrc.split("type=js"); absrc = _absrc[0] + 'type=js;referrer=' + encodeURIComponent(document.location.href) + _absrc[1];document.write('');Cardiovascular-kidney-metabolic health, or CKM health, is a perfect example. When any one of these systems is compromised, it can lead to problems with the others. Therefore, it’s not uncommon for health problems like heart disease, stroke, diabetes and kidney disease to develop or worsen simultaneously – a condition collectively known as CKM syndrome.The reverse is also true, so habits that are healthy for your heart will have a positive effect on your kidneys and metabolic system and vice versa. Consider these simple strategies that align with the American Heart Association’s Life’s Essential 8, a list of healthy steps that can improve overall health. Learn more about how these habits and health measures affect your CKM health at Heart.org.Choose Healthy Foods – Food is your body’s fuel, so fill your tank wisely. Certain types of foods can help your blood pressure, cholesterol, blood glucose and triglycerides stay within healthy ranges, while poor nutrition can push those numbers into more dangerous territory. Focus on vegetables, fruits, whole grains, plant-based proteins (e.g. beans, legumes and nuts) and lean animal proteins (e.g. seafood, skinless poultry and low-fat dairy). Drink plenty of water throughout the day and limit added sugar and salty or fatty foods.Stay Physically Active – Exercise doesn’t have to feel like a chore – in fact, some of your favorite hobbies may already count. The American Heart Association recommends aiming for 150 minutes per week of moderate physical activity like dancing, gardening or walking, moving quickly enough to elevate your heart rate and break a light sweat. Alternatively, choose 75 weekly minutes of vigorous exercise that gets you breathing hard and fast; think running, swimming, playing tennis or riding your bike on hilly terrain.Avoid Nicotine – Tobacco and other nicotine products can raise your blood pressure, damage blood vessels and increase your risk of heart attack and stroke, which are all bad news for your CKM health. If you’re currently trying to quit, you aren’t alone, so don’t be afraid to seek out support groups and resources to help. Prioritize Healthy Sleep – Sleep gives your body a chance to rest and recover from the day, but it’s often one of the first things people sacrifice when life gets busy. Poor sleep can increase your risk for heart disease, weight gain and other issues. Aim for a solid 7-9 hours a night. Keep your bedroom cool, dark and comfortable, and do your best to limit distractions like late-night smartphone scrolling.Watch Your Blood Pressure – When your blood pressure is high, it forces your heart to work harder to pump blood through the body, which can weaken it over time. It can also damage the delicate arteries in and around the kidneys, putting CKM health further at risk. Information is power, so check your blood pressure frequently to know whether further action is needed to keep it under control.Manage Your Blood Sugar – High blood sugar can damage the kidneys, eyes, blood vessels and more, thereby increasing your chance of developing harmful CKM conditions. Controlling blood sugar is particularly important for people with diabetes. If you don’t have diabetes and still experience frequent blood sugar spikes and crashes, talk to your doctor.Control Your Cholesterol – Cholesterol comes in both “bad” (LDL) and “good” (HDL) forms, requiring a balancing act to keep your levels within a healthy range. If LDL is high and HDL is low, your risk of clogged blood vessels, heart attack and stroke are higher. Healthy levels keep blood flowing to your heart and kidneys, supporting your metabolic health in the process. See your doctor for regular bloodwork so you can monitor cholesterol changes.Maintain a Healthy Weight – Since excess body weight puts pressure on the heart, kidneys and other organs, a healthy body weight helps lower your risk of CKM syndrome. Whether you’re hoping to maintain or reduce your weight, regular exercise, healthy eating and quality sleep are all great ways to achieve your goals.
Free cholesterol tests on the NHS are great – but here’s the five-point health MOT I’d really like to see
You could be walking around symptom-free and not know you’re pre-diabetic, living with hypertension or at a high risk of a heart attack, says public health academic Prof Devi Sridhar
Lifestyle Medicine and the Science of Cholesterol Reduction: A Systematic Review of Non-medication Approaches Among Adults
Dyslipidemia is a major modifiable risk factor for cardiovascular disease and remains highly prevalent despite advances in lipid-lowering therapy. Lifestyle medicine has emerged as a comprehensi...
Statins can safely cut risk of heart attacks or strokes in healthy people aged over 70, world-first clinical trial shows
Australian-led trial finds low risk of side effects from common cholesterol-lowering medication for otherwise healthy older people
An Experimental Single-Time Treatment Slashed Cholesterol for a Year
A small gene-editing study significantly reduced LDL cholesterol levels, and the results have stuck a year later.
The hidden health cost of dollar store groceries
New UC Riverside research shows a link between dollar store food quality and higher rates of obesity, high blood pressure, cholesterol, and type 2 diabetes.
Lester Ang Named Among Silicon Valley Business Journal’s “40 Under 40”
On August 14, 2026, Silicon Valley Business Journal named Wilson Sonsini corporate partner Lester Ang to its 2026 class of “40 Under 40” honorees, which showcases a new generation of leaders helping…
Less Inflammation, Lower Blood Pressure and Cholesterol: Science Says Drink a Glass of Orange Juice Every Day
Orange juice influences genes that control inflammation, blood pressure, metabolism, and blood sugar.
For decades, we were told to choose low-fat dairy. New research says otherwise
Full-fat dairy may be healthier than conventional advice has suggested. In a 12-week study, adults who ate three servings a day showed no meaningful increases in weight, body fat, cholesterol, or insulin resistance. They also experienced improved blood pressure and consumed more calcium, protein, and vitamin D. The findings suggest dairy’s complex structure may matter more than its saturated fat content alone.
The sneaky kind of cholesterol that may be threatening your heart health
Lipoprotein(a) isn’t part of a standard lipid panel and is largely driven by genetics. Here’s why it’s important to get your level checked.
Viagra could do more than advertised as study reveals surprising health superpower
Sildenafil, Viagra's active ingredient, may restrict cancer metastasis by limiting cancer cells' cholesterol access, a new study has found.
Microplastics may be affecting cardiovascular health
Heart attack patients have more than cholesterol in their arteries
A common sugar may help cancer cells break free and spread
Chemotherapy-surviving ovarian cancer cells may release fructose to help neighboring tumor cells loosen, escape, and spread. The discovery suggests that sugary diets and cholesterol-lowering drugs could influence cancer progression, though the effects have not yet been confirmed in patients.
Cubs acquire reliever Ryan Zeferjahn from Angels for Moisés Ballesteros
The Cubs made a big move to shore up the back of their bullpen with a hard-throwing right-hander.
Coffee and heart health: What experts say about its potential benefits, risks
Orlando Health cardiologist Dr. Sandip Patel discusses the American Heart Association's findings on coffee and heart health, along with updated cholesterol guidelines.
Millions more Americans may now be eligible for statins. What the new cholesterol guidelines mean
Updated cholesterol guidelines could make more than half of adults ages 30 to 79 in the United States eligible for statins. Here’s what patients should know.
Guernsey health pilot finds 107 undiagnosed high cholesterol cases
The four-month health pilot also found 65 undiagnosed cases of islanders with high blood pressure.
The Heart-Healthy ‘Superpower’ Nutrient That Doctors Love
In TODAY.com’s Expert Tip of the Day, a doctor explains why the nutrient helps lower harmful cholesterol and helps to stabilize blood sugar.
FDA approves first cholesterol pill of its kind
Enlicitide, the new oral PCSK9 inhibitor from Merck, will be sold under the brand name Lipfendra. It is approved to reduce LDL-C in patients with hypercholesterolemia, including HeFH.
Merck’s cholesterol pill gets US FDA approval
Merck said on Thursday the U.S. FDA has approved its cholesterol pill, the first of its kind to receive the health regulator’s nod, bolstering the drugmaker’s efforts to diversify beyond its blockbuster cancer treatment Keytruda.
Orlando Magic Summer League Standout Turning Heads
Lester Quinones flashes high-level shot-making and elite defensive potential, as Noah Penda’s clutch rim protection fuels a gritty victory over rival Miami in Las Vegas.
Millions may be getting the wrong cholesterol test
A new study suggests that apoB, a blood test that measures harmful cholesterol particles, is better than standard LDL cholesterol testing for deciding who needs more intensive treatment. Researchers found it could prevent more heart attacks and strokes while remaining cost-effective for the U.S. healthcare system.
The Fat ‘Upgrade’ A Doctor Recommends To Lower Bad Cholesterol
In TODAY.com’s Expert Tip of the Day, a doctor explains why we need fat and how to choose the best type for heart health.
Over-40s with obesity have normal-BMI cholesterol and blood pressure levels, study finds
Success of statins and blood-pressure drugs hailed as researchers find some people with obesity were ‘better off’
Statins and blood pressure drugs changing health risks of obesity, study suggests
New research shows obesity patients over 40 are managing blood pressure and cholesterol as well as healthy-weight peers, but younger adults remain at risk.
Danny Glover Reveals Alzheimer’s Diagnosis on TODAY: EXCLUSIVE
The 79-year-old “Lethal Weapon” star shared with Lester Holt that he was diagnosed with the progressive neurodegenerative disease a few years ago.
'Amaze, amaze, amaze': in Project Hail Mary, science and friendship save the day
Andrew Glester and Tushna Commissariat delve into the science and story of
Nhouyvanisvong, Green Among Attendees at NCAA Career in Sports Forum
Macalester College rising senior Adi Nhouyvanisvong (Wayata, Minn./Minnetonka) of the women's soccer team and rising junior Jay Green (Roseville, Minn./Mounds Park Academy) attended the NCAA's Career in Sports Forum, held May 27-30 at the NCAA headquarters in Indianapolis, Ind.
Breakfast, lunch, dinner to hit 30g fiber goal: Nutrition scientist
You may eat fiber for gut health, but it plays many crucial roles in the body, from lowering cholesterol to helping to control glucose levels.
Irene Pritzker buys Crowns’ Streeterville condo for $5.5 million
A member of the Pritzker family has emerged as the buyer of billionaire philanthropists Lester and Renee Crown’s longtime condominium at the Water Tower Residences in Streeterville.
First There Was Noise, Now There's Just Wyndham
For all of the chatter around Clark, there is now a very simple way to describe him: two-time U.S. Open champion. That’s more U.S. Open wins than Scheffler, McIlroy, Snead, Mickelson, Faldo, Ballesteros, Norman, Singh, Schauffele, Collin and Justin Thomas…combined.
Cancer dominates PFAS conversations — science points elsewhere
Studies link PFAS exposure to cholesterol, immune function, even bone density — findings that rarely make headlines. The cancer question remains open, and the list of what science is still […]
Family of teen injured at Butte carnival shares health update
Butte-Silver Bow Sheriff Ed Lester shared a statement Tuesday morning on behalf of the family of the teen injured at the carnival in Butte on Sunday.The family
Genes vs. environment: What really determines your health?
A family history of heart disease, diabetes or high cholesterol can feel like a warning about what’s ahead, but genes are only part of the story.
Genes vs. environment: What really determines your health?
A family history of heart disease, diabetes or high cholesterol can feel like a warning about what’s ahead, but genes are only part of the story.
Dr. Elisabeth Rosenthal on health care
Dr. Elisabeth Rosenthal sits down with Lester Holt to discuss the challenge of reforming the American health care system.
Phone calls from a pharmacist could help people achieve healthy cholesterol, say researchers
Regular follow-up calls from a pharmacist can help people lower their "bad" (LDL) cholesterol by reminding them to take their medication, based on research presented at the British Cardiovascular Society ...
Role of Physical Activity in Obesity Treatment and Cardiometabolic Health
Obesity affects 42% of adults in the United States and is strongly associated with major cardiovascular disease risk factors, including high blood pressure, abnormal cholesterol levels, and insulin resistance, making effective obesity treatment a critical public health priority.
Move more for your health, not just for the scale
Statement Highlights: Regular physical activity improves blood pressure, insulin sensitivity, cholesterol levels and cardiorespiratory fitness in adults with overweight or obesity, independent of weight loss, according to a new scientific statement...
Omega-3 fish oil shows promise against type 2 diabetes
A new study suggests fish oil may help reduce insulin resistance even in people who aren't obese. In diabetic rats, omega-3 supplementation improved blood sugar levels, cholesterol, and inflammation by shifting immune cells into a more anti-inflammatory mode.
Everybody Plays Adaptive Sports Field Day showcases sports opportunities for all
Lester Bennett II of Munhall feels like he was baptized as an adult while water skiing in the Allegheny River. “When I fell in that water and kept...
One-and-Done Heart Disease Prevention? Scientists Show It May Be Possible.
A single infusion of an experimental gene-editing drug seemed to reduce LDL long-term in a small trial. The results may point to something “curative,” one expert said.
One-and-Done Heart Disease Prevention? Scientists Show It May Be Possible.
A single infusion of an experimental gene-editing drug seemed to reduce LDL long-term in a small trial. The results may point to something “curative,” one expert said.
Experts have found a new type of cholesterol. And it could be the most dangerous | BBC Science Focus Magazine
Experts have found a new type of cholesterol, and it could be the most dangerous for your long-term health.
Scientists discover hidden liver switch that cuts harmful cholesterol
Scientists at UT Southwestern have uncovered a surprising new “master switch” that helps control how much cholesterol the liver sends into the bloodstream. The newly identified protein, HELZ2, works by shutting down the genetic instructions needed to produce apoB — a key building block of the cholesterol-carrying particles linked to clogged arteries and heart disease.
The surprising cholesterol-raising foods that fly under the radar
Many foods we consider healthy and natural can actually raise cholesterol levels. But it doesn't mean we should cut them out of our diet entirely.
This lesser-known cholesterol can quadruple your heart-attack risk
Heart specialists now recommend that everyone get tested for lipoprotein(a). Here’s what to know about it.
How jellyfish bycatch could be valuable collagen source for cosmetics and biotech
Dr Ainara Ballesteros is a Juan de la Cierva postdoctoral researcher at the Institute of Environment and Marine Science Research at the Catholic University of Valencia, where she leads a research group focused on jellyfish biology, aquaculture, and the sustainable use of marine resources. Her work is centered on developing innovative solutions based on marine science, particularly through the study of underused organisms as sources of high-value compounds within circular bioeconomy and zero-waste strategies. She is joined in this work by Raquel Torres, a PhD student at the same institute, who is carrying out her doctoral thesis within this line of research, focused on jellyfish valorization, collaboration with the fishing sector, and the sustainable management of marine resources. They are co-authors on a new Frontiers in Marine Science article which investigated whether jellyfish accidentally caught by small-scale fishers in Spain could be transformed into a valuable resource instead of being treated as waste. The team worked side by side with fishers to better understand their perceptions of jellyfish bycatch, identify which species are most frequently caught, and evaluate whether one of them, Rhizostoma pulmo, could serve as a sustainable source of high-quality collagen.
Fantasy Baseball Waiver Wire: Moisés Ballesteros looks like a top hitting streamer this week
New treatment cuts bad cholesterol by nearly 50% without statins
A new breakthrough could change how high cholesterol is treated, offering a powerful alternative to traditional drugs. Researchers have developed tiny DNA-based molecules that shut down PCSK9—a key protein that keeps “bad” LDL cholesterol circulating in the blood. By blocking this protein, cells can absorb more cholesterol instead of letting it build up in arteries, dramatically lowering levels linked to heart disease.
MLB legend uses late teammate's story to spread awareness on heart health, high cholesterol
Albert Pujols teamed up with Sierra Kile to honor late St. Louis Cardinals pitcher Darryl Kile's legacy and spread awareness about high cholesterol risks.
The surprisingly simple way to improve your cholesterol
High cholesterol is strongly linked to serious health risks. Here's how to stay healthy.
“Leaving Neverland” director says Michael Jackson was 'worse than Jeffrey Epstein,' fans want to forget abuse claims
"How can you tell an authentic story about Michael Jackson without ever mentioning the fact that he was seriously accused of being a child molester?" Dan Reed asked.
Scientists remove “zombie” cells and reverse liver damage in mice
A rogue set of “zombie” immune cells may be driving aging and fatty liver disease by flooding tissues with inflammation. Researchers found these cells accumulate with age and high cholesterol—and can make up most of the liver’s immune cells in older mice. When scientists removed them, liver damage was dramatically reversed, even without diet changes.
Men and women with obesity face very different hidden health risks
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Your Thymus and Your Healthspan
Our thymus gland plays a central role in the development or our immune system, specifically for supporting T cell development (how these cells got their name, maturation and differentiation in the thymus) and discriminating between self and foreign, non-self antigen proteins with production of dendritic cells. As we age, our thymus gland shrinks—the process known as involution—with progressive change from spongy to fatty tissue, with loss of functionality. But this process, with respect to timeline and extent, markedly varies from one person to the next. And to make things even more complicated, our thymus gland anatomy and precise location in the chest also is highly variable. So the famous Frank Netter diagrams from the 1960s (such as at left below) don’t capture the remarkable heterogeneity that a random set of 12 chest CT scans (below at right). What I consider as 2 landmark papers in Nature this week (here and here) used AI to quantify health of the thymus in 2 large cohorts, and then correlate the metric to a broad array of health outcomes. In this edition of Ground Truths, I’m going to cover three questions: (1) How was thymus health determined by AI?; (2) How is thymus health linked to key clinical outcomes? and (3) Are there ways we can promote a healthy (aka rejuvenate) thymus gland in our later years? Subscribe 1. How was thymus health determined by AI? This was accomplished by extensive work developing and validating an AI pipeline for 2 stages, the first for localization and segmentation of the thymus bed, and the second to quantify a digital marker, termed the thymic health score. There’s a lot to this algorithmic development, so I won’t go into all the details, but just provide a rudimentary outline of what was done. The 1st stage used supervised learning with 2 radiologists reviewing 2,461 chest CT scans. That work trained a 3D U-Net model to automatically identify the thymic bed’s 3D cropped region using center of mass coordinates, which reached 99.8% accuracy. The 2nd stage used a foundation model that was pre-trained with SwAV (which stands for Swapping Assignment between multiple Views), a self-supervised model, that generated a high-dimensional thymus representation of 4,096 features. That compares to the radiology reductionist and subjective scoring of 0 to 3 where 0 means the thymus is fully degenerated and fatty, and 3 is considered dense, intact glandular soft tissue. Notably, the self-supervised learning (SSL) performance was superior to supervised (AUC ~0.75 vs 0.55, respectively) reflecting the shallowness of the 0-3 classifier vs SSL’s holistic, self-taught AI. The thymic health score ranged from 0 to 100, with the highest number indexed to fully preserved thymic health. The algorithmic work extended to explainability with both Shapely value distribution, meaning the model was holistic not relying on any “magic” pixel, and occlusion sensitivity, demonstrating the model’s performance was not affected by ribs, sternum, lung tissue, but rather focused on the thymic bed directly. Below are a few saliency maps from the occlusion sensitivity that indicate the thymic bed focus, not affected by neighboring structures, using the jet color scale. Now the AI was ready for processing ~25,000 CT scans, each over 30 MB files, from the 2 large participant cohorts to provide a thymic health score, it did so in less than 14 hours, which is less than 2 seconds per scan! Share 2. How is thymus health linked to key clinical outcomes? The two cohorts were the National Lung Screening Trial, NLST (N=25,031) and the Framingham Heart Study, FHS (N=2,581) each with baseline demographics and long term follow up of >12 years for health outcomes. From the NSLT, you can see below that increased age and body-mass index were correlated to reduced thymic health. And, overall, men had reduced thymic health scores compared with women. There are a lot of graphs in the paper for outcomes, for both the NLST and FHS cohorts. To simplify the major outcomes, below is a composite Figure with striking reduction of all-cause mortality and for the different causes of death. The results were consistent between the 2 cohorts. For example, the cardiovascular mortality hazard ratio average was 0.57 in NLST and 0.38 in FHS (weighted to be 0.53 for the aggregate). The reduction of mortality also extended to digestive diseases and pulmonary disease (data not shown below). Lung cancer incidence was reduced by 36% for high vs low thymic health (Figure below, with a panel -incidence and b panel-mortality, adjusted for age, sex, BMI, smoking status). Notably, there was a smoker’s paradox: lower incidence and improved survival for lung cancer in smokers who had a high thymus health score. Smoking was associated with lower thymic scores whereas alcohol was not. Higher thymic health was linked to higher HDL cholesterol, lower triglycerides, lower fasting blood glucose, and lower systolic and diastolic blood pressure. Inflammation biomarkers, such as C-reactive protein and interleukin-6, were elevated in the people with lower thymic health scores. In their second paper, the same team looked at the relationship between thymic score and outcomes for 3,476 patients receiving cancer immunotherapy. The non-small cell lung cancer progression-free survival was reduced in patients with low thymic health score. A parallel relationship for survival was seen for other types of cancer including melanoma, breast, and kidney with a 44% lower risk among high thymic scores (Figure). A similar pattern was seen with different immune checkpoint inhibitors. The thymus health score outperformed programmed death ligand-1 (PD-L1)and tumor mutation burden (TMB) assay of the tumor and was an independent prognostic marker of progression-free survival. In this dataset, a direct connect with thymus score and adaptive immune function was noted with a correlation before cancer treatment for both T-cell diversity and thymus T-cell production (a metric known as T cell receptor excision circles). Thymus Removal Study There is a highly relevant citation about thymus function before moving onto ways to rejuvenate it. In 2023, a very important study of thymus removal during cardiothoracic surgery was published, with 1146 patients undergoing thymus removal vs 1146 matched controls (mean age 55 years). The adverse outcomes for thymus removal were striking, with a 2.9 higher risk of all-cause mortality and doubling of cancer incidence, 1.5 fold increase in cancer mortality, and 1.5-fold increase in autoimmune diseases. The immune function showed marked compromise after thymus removal, as reflected by CD4+ and CD8+ T cells (Figure below) Share Ground Truths 3. Are there ways we can promote a healthy (aka rejuvenate) thymus gland in our later years? In recent months we’ve learned a lot about the process of thymus involution and the pathways by which this may be modulated. Thymus involution is primarily due to loss to thymus epithelial cells (TECs) and there are 2 subtypes with different functions: the cortical, responsible for positive selection of T cells, and the medullary, for negative selection. When adipose tissue infiltrates the thymus, thymic adipocytes are pro-inflammatory, knocking out T-cell output. Likewise, systemic inflammation, or “inflammaging,” from smoking, obesity, and chronic stress promote thymic adipocytes. Now, from preclinical studies, we know about key pathways that account for these processes. Historically, back in 2014, FOXN1 was recognized as a single master transcription factor essential for TEC function, with studies in mice with forced FOXN1 upregulation leading to thymus regeneration. That laid the foundation for potential regrowth of quiescent thymus cells. It took awhile to find pathways to accomplish this goal and to even refute its role as the master regulator. The Liver-Thymus Axis Feng Zhang and his team recently showed that injection of an mRNA vaccine to the liver encoding DLL1, IL-7 and FLT3-L in combination, factors known to support thymopoiesis (Figure), successfully enhanced immune function in aged mice. However, the effect was transient. The FGF21 Story Two reports in 2025 addressed the thymus gland’s production of FGF21, a growth factor (fibroblast growth factor 21) and its control of thymus involution. This growth factor is also produced by the liver, but it doesn’t have impact on the thymus in aged rodent models. In contrast, The liver’s hepatocyte growth factor (HGF) has been shown to reverse senescent TEC structural changes. Growth hormone stimulates production of insulin growth factor-1 (IGF-1) in the liver and the thymus. Two small studies in human participants (TRIIM, for Thymus Regeneration, Immunorestoration, and Insulin Mitigation) of 6 and 50 people, respectively, treated with combined human growth hormone, metformin and DHEA, suggested the potential of slowing epigenetic aging and improving thymus mass and function. But the combination of drugs, small sample, and lack of controls make conclusions murky. Increased thymus FGF21 led to increased CD8 T cells in old mice and extended healthspan and improved physical performance. Building on the previous FOXN1 data, ablation of β-klotho, the obligatory co-receptor for FOXN1, accelerated thymic aging. The benefit to FGF21 was confirmed in a companion paper using an FGF21 knock-in mouse model showing thymus enlargement and increased TECs throughout the lifespan. (schematic Figure below). The accompanying editorial for these 2 papers speculated: “The proposed link between age-associated thymus involution and organismal aging is intriguing, and suggests we might seek to achieve systemic rejuvenation by counteracting thymic involution.” Other Factors Lessons from the Axolotl (Mexican Salamander) In an elegant set of experiments of the axolotl (Figure), known for its complete thymus regeneration after total surgical removal, mediators were identified. Surprisingly FOXN1 was dispensable. But midkine, a growth factor, appeared to be the driver, the initiator of thymus cell growth, survival, and repair. Other components that contributed were Postn+ (periostin-expressing mesenchymal niches) and Ccl19, a chemokine protein from the bloodstream. RANK and RANKL RANK (receptor activator of nuclear factor κB its ligand (RANKL) have been considered key regulators of medullary TECs. In a study of both aged mice and human thymus cell cultures, their key role was confirmed, with multiple benefits of resorting TEC function, recruitment of progenitor cells, and T cell development. Subscribe Summing Up This body of work strongly supports the health of the thymus gland as a critical regulator of human healthspan, not just a correlate or link. The new landmark studies are reinforced by the regenerative biology experimental models that have shown, via an array of mediators, that healthspan of aged mice is at least in part dependent on thymus gland function and its critical role for maintaining adaptive immunity. It sure seems that we’d be better off having an immune reservoir of naive T cells instead of a profile in older adults of exhausted, low quality, memory T cells, with a senescent phenotype. It is striking that we ignored the importance of the thymus gland for many decades. A wake-up call was the results of the thymectomy matched control study reviewed here, with the opposite of high thymic health score improved health outcomes. The convergence of AI and healthspan here is notable. The exceptional and laborious work for developing and validating (no less explaining) the AI to quantify thymus health set the foundation for probing the connect the major health outcomes in two cohorts with extensive follow-up. We’ve never had a way to meaningfully quantify the thymus gland before, so this represents important leverage of supervised, self-supervised, and transformer models. The study wouldn’t have been possible without AI. And it begs the question as to whether there are ways we can maintain our thymus at a high health score. But it’s not so simple to rejuvenate our thymus. There are multiple risks including the induction of autoimmunity, increasing the risk of cancer, and inducing a pro-inflammatory state. For example, factors that increase TEC proliferation could compromise the medulllary negative selection process and leak out auto-reactive (self-attacking) T cells. Thymic cells could be induced to proliferate, but we know, for example, that growth hormone and IGF-1 are associated with an increase risk of cancer. If thymus rejuvenation doesn’t clear out the accumulated senescent cells in older adults, then inflammation within the gland could block the production of TECs. Keeping these risks in mind, we now have identified many ways to keep our thymus healthy as we age that undoubtedly will be tested in clinical trials going forward. Ultimately, the benefit-to-risk tradeoffs will be defined. In the meantime, we have desperately needed an immunome. As I’ve stressed in multiple prior Ground Truths, we have no test in the clinic to assess a patient’s immune status! It was very encouraging for me to get an email from Hugo Aerts, the senior author of the landmark papers in the days after they were published: “I also wanted to say that your Substack on “Why We Need an Immunome” was inspiring for this work. We found it a very compelling perspective and greatly enjoyed reading it.” Just having an assessment of a person’s immune status via a chest CT scan, with millions of these performed per year, might help in guiding the right immunotherapy for cancer (e.g. more intensive, combinations for those with low thymic health scores) and help define people who are increased risk for age-related diseases of cancer, cardiovascular, and neurodegenerative. The main theme of Super Agers is that we now have many layers of data (genetics, proteins, biomarkers, organ clocks that can be integrated via multimodal AI) for us to define a person’s specific risk decades before one of these age-related diseases leads to symptoms, enabling prevention. From the new studies this week, we can add thymus health score as yet another way to understand a person’s risk, a window into their adaptive immune system and healthspan. And perhaps someday we will be able to safely rejuvenate the thymus, or maintain its health through one’s life, and use the thymus health score to monitor. NB: I wrote this post (No A.I.) A Quick Poll Loading... ********************************************************************* Thanks to Ground Truths subscribers (now > 200,000) from every US state and 212 countries. Your subscription to these free essays and podcasts makes my work in putting them together worthwhile. Please join! If you found this interesting PLEASE share it! Share Ground Truths Paid subscriptions are voluntary and all proceeds from them go to support Scripps Research. They do allow for posting comments and questions, which I do my best to respond to. Please don’t hesitate to post comments and give me feedback. Let me know topics that you would like to see covered. Leave a comment Many thanks to those who have contributed—they have greatly helped fund our summer internship programs for the past two years. It enabled us to accept and support 47 summer interns in 2025! We aim to accept even more of the several thousand who will apply for summer 2026.
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