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Under 500 Employees, Over $500 billion: Small Business Payroll Taxes
Small businesses, those with fewer than 500 employees, are a pillar in the U.S. economy and account for a large share of federal payroll tax revenues. These taxes are paid by both the employer and employee and are primarily used to fund the Social Se
Commanders sign DT Byron Cowart
Colorado New Business Filings Show Growth in q2
New business filings in Colorado increased sharply in the second quarter of 2026, rising both from the previous quarter and a year earlier, according to a new report from the University of Colorado Boulder and the Colorado Secretary of State’s Office.
Abbott and Google launch first-of-its-kind partnership to transform everyday health through glucose insights and AI
Multi-year collaboration combines ongoing glucose insights from Abbott's Lingo biowearable with Google Health's technology to create a more comprehensive view of personal health Partnership...
The U.S. Healthcare System is Already Mostly Socialized
Now that Abdul El-Sayed is the Democratic nominee for Michigan’s open Senate seat, the outcome of this crucial race will depend mainly on two things: Whether Republicans succeed in demonizing El-Sayed because he’s brown and a Muslim, and whether they succeed in demonizing him as a left-wing radical. I will defer for the now the question of whether bigotry will be effective this year, although I will address it another day. What I want to address instead is El-Sayed’s signature issue — healthcare. Yes, El-Sayed advocates Medicare for All, a position the usual suspects denounce as “socialism.” I will get to the politics of his stance soon. Today, however, I want to talk about the substance. We should be clear that El-Sayed doesn’t even call himself a socialist. On the contrary, he explicitly disavows the label, saying “I’m a capitalist who just knows about capitalism”. In fact, as I explained in a previous post, the policies that El-Sayed advocates qualify him as a social democrat, not a socialist. Still, El-Sayed advocates a system under which the government would pay almost all medical expenses. Isn’t that socialism? Well, if that is the criterion then much of U.S. healthcare is already socialist. In fact, the government’s role is so large that U.S. healthcare is better described as partially privatized socialism than as anything resembling a free market. Let’s start with the raw numbers on health insurance, which pays the bulk of Americans’ medical expenses. Americans receive health insurance either from private companies or from public programs, overwhelmingly Medicare and Medicaid. Here’s what the breakdown of coverage and spending between private and public looked like in 2024: While a majority of Americans with health insurance get it from private companies, well over 100 million of us are covered by government programs instead. And these government programs pay more total dollars for medical bills than the private insurers do. Why do government programs that cover a minority of the population account for a majority of health insurers’ outlays? Mainly because Medicare covers seniors, and we’re expensive. Also, while Medicaid covers many younger Americans, disabled and elderly beneficiaries account for most of its spending. Even by the raw numbers, then, U.S. health insurance looks as much public as private. But that understates the government’s role: Private health insurance in the U.S. is both highly regulated and heavily subsidized. This is obviously true for the insurance coverage purchased by tens of millions of Americans through the exchanges established by the Affordable Care Act. But employment-based health insurance, which covers 161 million Americans, is far more of a government creation than most people realize. For employment-based insurance exists largely because of huge implicit government subsidies that come with major strings attached. Here’s how that works. If your employer pays you $10,000, that’s taxable income. But if your employer pays $10,000 toward a company health insurance plan that meets certain criteria, it isn’t taxable. That’s a huge effective subsidy, running at more than $300 billion a year. Take that subsidy into account, along with the more than $100 billion per year spent subsidizing policies purchased under the ACA, as well as the outlays on Medicare and Medicaid, and net effect is that the government pays for more than two-thirds of Americans’ health insurance. Granted, there are strings attached. Roughly speaking, employment-based health plans can’t discriminate based on medical history — that is, they can’t deny coverage to employees with pre-existing conditions — and they also can’t offer the plans only to highly compensated employees — a health plan that is only for the C-suite is considered taxable income. So given the restrictions of the federal tax code, employer-based health insurance is a lot like Obamacare, which also prohibits discrimination based on medical history and provides subsidies to make insurance affordable to lower-paid workers. The fact is that virtually all of private healthcare insurance is already well under some form of government control through regulation and tax subsidies. How should we think about this system? First of all, is Medicare socialist? Don’t tell anyone, but the way Medicare operates — it covers every senior’s medical expenses, whatever they turn out to be, while being funded by taxes that depend on one’s income — could be summarized by the old Marxist slogan “From each according to his ability, to each according to his need.” And back in 1961, when Ronald Reagan was the face of a last-ditch effort by the American Medical Association to block the creation of Medicare, he denounced Medicare as “socialized medicine” and warned that it would destroy our freedom. In reality, American freedom survived until Jan. 20, 2025, while Medicare is immensely popular, with an 82 percent favorable rating in the most recent KFF survey. Medicaid, government health insurance for lower-income Americans, comes in at 73 percent. This is in sharp contrast to public views about private insurers, who are widely disliked if not hated and accused of denying essential care. Furthermore, if Medicare is socialism, then the whole U.S. health insurance system, with the government paying most of the bills and placing conditions on private insurers, is almost equally socialist. If you insist on calling any program the government pays for and regulates socialist, then U.S. healthcare would best be described as a partially privatized form of socialism. And one must ask, what is the point of the part that is privatized? Do private insurers add anything positive? Or are they simply parasites, skimming off money that could have been paying for care? The case for viewing insurers as parasites is strong. Many Medicare benefits are now delivered via Medicare Advantage, that is, plans paid for by the government but run through insurance companies. MedPAC, an independent advisory commission, estimates that last year Medicare Advantage plans were overpaid by $84 billion, thanks to practices such as “upcoding,” in which patients’ health problems are overstated to get larger sums from Medicare. Assessing the waste from employer-based insurance is harder, but most evidence suggests that private insurers have substantially higher administrative costs than Medicare does. Furthermore, the complexity of private insurance, with multiple payers all trying to deny care when they can, is a huge burden both on providers — doctors, nurses, and hospitals — and on patients. What do private insurers offer to compensate for these costs? One must go through intellectual contortions to avoid the conclusion that they are, in fact, parasites. Which brings me back to El-Sayed. In supporting Medicare for All, he’s basically calling for an end to the partial, parasitic privatization of a healthcare system that is already hugely dependent on public funding. When one looks at it that way, it’s not at all a radical proposal. Admittedly, the political lift requires overcoming the opposition to higher taxes to pay for Medicare for All. Political realism rather than economics was the reason I and many other progressives supported Obamacare, with all its complexities, rather than demanding an immediate move to Medicare for All. But the political calculus may very well have shifted since the 2000s, as Americans are fed up with a system of unaffordable premiums, rampant claim denials, and byzantine claim administration. Moreover, funding healthcare insurance through taxation would allow for a much more progressive distribution of the cost. That is, compared to the present system, middle-income households would pay less as high-income households would pay more. And the U.S. would stop wasting large sums on pointless administrative costs. So let’s be clear: El-Sayed’s healthcare platform is perfectly reasonable on the merits of cost, fairness and health efficacy. And with private insurers never more hated, while millions of Americans are losing their health insurance, 2026 may be its time. MUSICAL CODA
NFL training camp live updates, news, injuries for Aug. 11
WHO defends immunisation schedules after Trump orders fewer childhood shots
Trump loves data centers. Americans hate them
If there’s a true populist issue built for our time, it might be opposition to AI data centers. Lawmakers and candidates from both parties across states are increasingly positioning themselves as critics of data center proliferation. And recent primary results suggest it’s a pretty potent issue.
Wisconsin's Democratic showdown between Francesca Hong and David Crowley and more races to watch today
Eye On Entertainment: Whitney Houston Barbie Doll
Greg Dortch impressing in camp as potential fourth Lions receiver
Thanks in part to his familiarity with Drew Petzing, Greg Dortch could emerge as both a top specialist and No. 4 wide receiver.
Video: How We’re Covering an ‘Identity Crisis’ in Politics
Recent primary wins have posed critical questions for both Republicans and Democrats as they head into the fall midterms. Carolyn Ryan, managing editor of The New York Times, shares how reporters approach coverage of shifting political dynamics.
Hialeah's Bucky Dent Water Park shuts down days after reopening over health violations, permit issues
Big Bear bald eagle Jackie dies after lingering health issues
Tougher than armour, hard as diamond: China’s unbreakable crystal breakthrough
As profanity from politicans becomes normalized, what's allowed in political ads?
2026-27 Pittsburgh Penguins Player Projections: Ben Kindel
‘I’ve gotten things done’: Dems scramble to beat DSA Gov. Candidate in Wisconsin
HeyDay Entertainment to close after nearly 20 years amid planned Norman turnpike route
Can AOC moderate her views enough to appeal beyond the Democratic base?
Why LA Council chief says Nithya Raman reached ‘political bottom of barrel'
Council President Marqueece Harris-Dawson says despite Raman’s claims that she’s being punished for running for mayor against Karen Bass, she knew about her committee assignment change. Conan Nolan reports for the NBC4 News at 7 p.m. on Monday, Aug. 10, 2026.
Bo Nix is eager for preseason action
WAPO: Trump secretly switched planes using catering truck
2 fatally shot while leaving business on Chicago's South Side, police say
Three suspects opened fire on two people as they left a business Monday evening on Chicago's South Side, killing both victims, authorities said.
What Does Fenway Sports Group's Latest Business Moves Say About Upcoming Lockout?
What Does Fenway Sports Group's Latest Business Moves Say About Upcoming Lockout?
Trump-backed candidates amplify election fraud claims ahead of Midterms
Big Bear bald eagle Jackie dies after series of health setbacks
Ernst Names Small Business of the Week, Lone Arranger
Read the release on Sen. Ernst's website HERE. Throughout this Congress, Chair Ernst plans to recognize a small business in every one of Iowa’s 99 counties. RED OAK, Iowa – U.S. Senator Joni Ernst (R-Iowa), Chair of the Senate Small Business Committee, today announced her Small Business of the Week: Lone Arranger of Adams County. Throughout the 119th Congress, Chair Ernst plans to recognize a small business in each of Iowa's 99 counties. "Lone Arranger has been in full bloom in Adams County for more than 28 years,” said Chair Ernst. "One bouquet at a time, Jessica has created beautiful arrangements for countless occasions – from displays for Governors Chet Culver and Terry Branstad to serving as a longtime vendor at the Adams County Fair. Lone Arranger is beloved for its high-quality products and attentive customer service, all stemming from hard work that has not gone unnoticed." Lone Arranger got its start as the “Flower and Garden Center” founded by Dale and Caroline Jackson out of their home. Over the years, the business passed into the hands of Larry and Sherry Archer, followed by Ros and Darlene Peterson. In 1999, Jessica Wilson purchased the shop after completing two internships there and earning a degree in floriculture from Kirkwood Community College. Today, under Jessica’s leadership, Lone Arranger has continued to grow its presence both locally and beyond. The shop contributed to the award-winning Rain Bird float featured in the 2010 Tournament of Roses Parade and has provided decorations for community organizations and events, including the Adams County Chamber of Commerce. The florist is cherished by Iowans for its versatility to cater to all events, including proms, weddings, and baby showers. Jessica’s “Operation Dream Closet” helps high schoolers in need access free prom attire through donations and has made an exceptional difference in the local community. Stay tuned as Chair Ernst continues to recognize outstanding Iowa small businesses with her Small Business of the Week award. ###
Cook County Health CEO on Medicaid Cuts, $100M Increase in Charity Care
Health Dept. survey asks where residents look for health information
JACKSON, Wyo. — The Teton County Health Department (TCHD) is interested in learning where the community finds health information. An online survey from TCHD asks questions about where health information is received and how residents prefer to learn about Health Department news. The survey, available in both English and Spanish, takes about 5 minutes and […]
How Jefferson Health is testing new treatment for brain disorder: "It's amazing"
Health officials stunned by Trump’s change to vaccine schedule: ‘I haven’t seen anything like this in my career’
Entertainment and trial attorney on legal issues shaping Tupac Shakur murder trial
Entertainment and trial attorney on legal issues shaping Tupac Shakur murder trial
Entertainment and trial attorney on legal issues shaping Tupac Shakur murder trial
Entertainment and trial attorney on legal issues shaping Tupac Shakur murder trial
No Sweat: Cardinals GM appears to shut the door on trading top pass rusher
Health Alert: Vibrio vulnificus kills 7 people, Taylor Farms recalls jalapeño products
Robotics in electrophysiology: Are we near an inflection point?
Peter Weiss, MD, details the evolution of EP robotics, including the movement toward remote procedures.
Judge pauses pied-à-terre tax rollout after homeowners allege botched launch
Staten Island Judge Wayne Ozzi heard arguments on a motion for a temporary restraining order to block the rollout of the pied-à-terre tax.
Saber's newest game trailer takes a shot at Gearbox's CEO, if you look closely
The first hint that something might be up with the recent debut trailer for Saber Interactive’s Rideshare Stimulator is an unusual choice of words—aside from that second one in the game’s title. “Don’t take your passengers too seriously,” the trailer’s narrator says, as he describes this upcoming game. It a car game about the gig work of driving eccentric people to their destinations, a riff on Crazy Taxi. And then, he says: “When I think I’ve met the randiest of passengers, someone even stranger gets in.” “Randiest”? That suggests “randy,” which usually means having strong sexual desire. Yet none of the oddball backseat occupants featured in the trailer seem particularly lustful. One is an old man who considers his grandson a failure, another shares the theory that birds might control traffic lights, another says he’s banned from an aquarium. A little later, there’s a license plate, shown 63 seconds into the trailer, on the front of an SUV: USB DRV It’s a Texas plate. The symbol between those letters is a cog wheel. If you know, you know. That’s a reference to Texas-based Borderlands game development studio Gearbox Software (their logo features a cog wheel). More specifically, it’s a reference to Gearbox’s CEO Randy Pitchford, who in 2018 found himself explaining the nature of video he’d saved on a USB drive that was found at a Medieval Times restaurant before being returned to the studio: “It was ‘barely legal’ porn. This girl’s handle was ‘Only 18.’” The “girl” in the video had committed a solo sex act that Pitchford, an avid practitioner of magic, found remarkable. “I realized, this is not a sex worker…This is a fucking magician.” Back then, the USB drive was central to competing lawsuits against Gearbox by the studio’s former lawyer and by Gearbox against him. A settlement in late 2019 “exonerated” Pitchford, per the Hollywood Reporter. The USB story has resurfaced at times, now in a trailer from a company that not long ago was corporate brethren with Gearbox. Saber vs. Gearbox The head of Saber told Game File that the reference is payback. “The dig is because Randy took shots at Embracer in Borderlands 4,” Saber CEO Matt Karch told me when I asked him about the license plate. “Without Embracer, Randy is performing magic tricks at birthday parties for a living.” Having interviewed Karch during a cross-country flight in late 2024, I can confirm that Karch was unimpressed with Pitchford during their time both working in the Embracer group. I’d approached him not out of surprise that there was animosity but that it was manifesting publicly now. Gearbox was founded in 1999, worked on a port of Halo early on, and developed hit series such as the loot-based sci-fi shooter Borderlands before it was purchased by The Embracer Group in early 2021 for $363 million (with a possible earn-out of over $1 billion, if certain targets were hit by 2027). Saber was founded in 2001, worked on a remaster of Halo early on, had a big hit with zombie shooter World War Z and was purchased by Embracer in early 2020 for $150 million, with a potential earn-out of up to $375 million. For a few years, the Embracer group was a voracious acquirer of game studios. Then, as investment dried up, it choked. In March 2024, Embracer sold Saber to an investment company controlled by Saber CEO Matt Karch, and it sold Gearbox in an all-stock deal to long-time Borderlands publisher Take Two Interactive. Other studios were shut down. Hundreds of developers were laid off. Gearbox didn’t say much about their Embracer experience, nothing too direct, at least. In the summer 2024, Pitchford told reporter and occasional Game File contributor Nicole Carpenter that Borderlands 4’s story was in some way thematically connected to Gearbox’s experience at Embracer: “There’s this cultural and emotional shift in me, personally, and at the studio. What does it mean to trade some autonomy for organization?” When Borderlands 4 came out, there was something stranger: the matter of “Embracer’s Bluff,” a location in the game featuring an AI-powered toilet and a large trash dump, according to a detailed Kotaku account of the place. Gearbox never commented on it; Take Two never got back to me about it when I asked them last year. By contrast, since Saber exited Embracer, Karch has been one of Embracer’s biggest defenders, casting their management as well-meaning and supportive despite the layoffs and studio closures that resulted from their excessive expansion. Like others, Saber’s Karch saw Embracer’s as a shot. With Rideshare Stimulator’s trailer, he’s returned fire. “It’s amazing to me how fast people forget those who went above and beyond for them,” Karch told Game File. A rep for Gearbox did not comment by press time. Game File is a reader-supported publication. Your backing makes my reporting—including any coverage of trailer-based beefs—possible. Good news! I’m currently running Game File’s first big sale of 2026. You can get a one-year subscription for 23% off. Click here to take advantage of the limited-time offer. And thank you for your support! Item 2: In brief… 🚫 Wal-Mart has laid off the staff of Restart, a games media outlet launched in 2024, Aftermath reports. 🟥 A GTA VI preview is on the way, at last, via an “extended look” that will premiere, unusually, on Netflix at 3pm ET on August 27, then officially go live elsewhere six hours later. Last week, Game File noted that Take Two label Rockstar Games is overdue for showing off GTA VI, based on the timing of the initial hands-off previews of GTA V and Red Dead Redemption 2. During a call with investors, Take Two CEO Strauss Zelnick said pre-orders for GTA VI were “unprecedented and astonishing,” but added the company can’t predict how many of those pre-orders represent bonus sales vs. sales that otherwise would have been made at launch. During the same call, Zelnick was noticeably bullish on the future of playing games over streaming cloud connections (predicting wider adoption in three or so years). He sounded unbothered by Sony’s plans to stop making discs for new games (he said the business is 90% digital already and predicted that there could still be limited edition physical editions of games “in the same way there’s still vinyl in the recorded music business.”) 👀 Take Two wrote off $43 million in their spring quarter after deciding “not to proceed with further development of an unannounced title in its pipeline from a third-party developer.” 🤔 Some rare age-demographics from a big publisher: Capcom recently told investors that “users in their 20s account for approximately half of the users of both Pragamata and Resident Evil Requiem.” Item 3: The week ahead Tuesday, August 11 Game releases: The Elder Scrolls IV: Oblivion Remastered (Switch 2; already out for PC, PS5, Xbox) continues the Bethesda strategy of putting Elder Scrolls games on everything; Royalty Free-For-All is a Smash Bros.-style fighting game featuring public domain characters such as Mother Goose brawling with Oliver Twist in a stage based on the original Little Shop of Horrors movie. Wednesday, August 12 Game release: Pro Jank Footy (PC, console) is an arcade-style Australian Rules Football game with increasingly ridiculous rules, the more you play (I enjoyed the Steam demo) Thursday, August 13 Game release: Super Mario Sunshine (Switch 2, originally released in 2002 on the GameCube) is released for Switch 2’s Nintendo Switch Online service. This game is the black sheep of 3D Mario games. It’s the successor to the breakthrough Super Mario 64 and the rare Mario game built around a single (vacation resort) theme. Mario’s got a water-spraying backpack, a Yoshi pal and a lot of blue coins to collect.
Teddy Bridgewater: Retirement is official this time
Bullard, Stagner reappointed as judges to Texas Business Court in Fort Worth
Governor Greg Abbott today reappointed all ten judges of the Texas Business Court Divisions to new two-year terms beginning Sept. 1, 2026. “Businesses
Christian McCaffrey sore, but OK as 49ers manage his workload
Bronny James faces pivotal Lakers season without LeBron on roster
SF politician apologizes over AI attack website, takes chatbot down
Speaker Emerita Nancy Pelosi called the chatbot a "gross misuse" of AI.
Bank announces philanthropic funding to get small businesses ready for 2028 Olympics
Shedeur Sanders, Deshaun Watson to alternate starts in Browns' first 2 preseason games
Christian McCaffrey out of Monday's practice with "tightness"
'Bachelorette' alum Joe Amabile gives health update on brain tumor
"Bachelor in Paradise" alum Joe Amabile and his wife Serena Pitt both shared updates on his health after a brain tumor surgery.
Fantasy Football QB Preview: Draft strategy, rankings, fades and sleepers
Singhs Vietnamese shuts down San Antonio locations after eight years in business
Singhs Vietnamese has permanently closed both San Antonio locations after not reopening from an August break. Co-founder Eric Treviño confirmed the 8-year banh mi and bowl concept has ended; no reason given.
Singhs Vietnamese shuts down San Antonio locations after eight years in business
Singhs Vietnamese has permanently closed both San Antonio locations after not reopening from an August break. Co-founder Eric Treviño confirmed the 8-year banh mi and bowl concept has ended; no reason given.
The Marc Philip Gemballa Marsien GT is an 830hp Porsche 959 for the 2020s
NYC Mayor Mamdani backs Amazon delivery worker bill, escalating fight with retail giant
Theme Park Controversy Proves Obsession Broke Everyone’s Brains
A controversial Halloween Horror Nights decision has fans debating whether a horror victim should be turned into a terrifying scare actor.
Robot24.com Launches Global Robotics News Platform With Original Reporting, Business News and Correspondents on Every Continent
Robot24.com has launched as a new global robotics news platform dedicated to covering the companies, machines, people and technologies shaping t...
‘Family Affair’ actress Kathy Garver reflects on child costar Anissa Jones’ death at 18
‘Family Affair’ actress Kathy Garver reflects on child costar Anissa Jones’ tragic death at 18 and reveals a haunting plea the star’s mother made to her shortly before her daughter died.
US Open Ticket Prices Surge Despite Sinner, Alcaraz Questions
Ticket prices kept climbing through both stars’ Cincinnati withdrawals.
‘They need each other’: What’s behind the new Syria-Russia accord?
Life On Earth Appeared Not Once But Twice, Both Times Evolving From A Common Genetic Code
For life to get started it may have depended on one of the rarest, and currently most expensive, metals on Earth.
Dodgers' Late-Season Slide Complicates MLB's Salary Cap Push
How the US far-right weaponised ‘inshallah’ against Abdul El-Sayed
The Odds: A Jobs Recession
President Trump: We are only ‘semi-negotiating’ with Iran
Patriots waiving 2024 third-round pick Caedan Wallace
Yahoo Sports' Preseason College Football Top 25: Can Texas A&M get over Texas hurdle and play for SEC title?
Chiefs Are Focusing On Improving Return Game This Season
MLB wild card standings: Which teams hold final playoff spots?
Italy-Spain fallout: united by geography, divided by politics
Italy and Spain's Schengen border spat over Ceuta has exposed a deeper migration rift, as domestic politics and rising far-right rivals harden both sides' positions.
AbCellera women’s health data top ‘most aggressive upside scenario,’ putting Astellas and Bayer on notice
AbCellera has reported phase 2 results “beyond even the most aggressive upside scenario” that its CEO dared to consider, boosting the biotech’s chances of challenging Astellas and Bayer for a women’s health market. The phase 2 clinical trial compared ABCL635, an antibody targeting NK3R, to placebo in patients with hot flashes caused by menopause. Investigators enrolled 92 postmenopausal women experiencing a mean of about 10 moderate or severe hot flashes per day. By Week 4, the number of moderate or severe hot flashes had fallen by a mean of 8.8 on ABCL635 and by 3.5 on placebo. That statistically significant, placebo-adjusted reduction of 5.3 hit the trial’s primary endpoint. The level of efficacy also cleared the bar set by existing drugs. While cross-trial comparisons can be misleading, AbCellera CEO Carl Hansen, Ph.D., had seen enough to start hyping the program. “We now view ABCL635 as a potential best-in-class non-hormonal therapy with strong differentiation against approved NK3R competitors across all important dimensions, including efficacy, safety, dosing and convenience,” Hansen said on a Monday morning conference call with investors to discuss the data. “We believe ABCL635 is now a highly de-risked program.” Last week, Hansen used AbCellera’s earnings call to set expectations for readout, with the CEO defining success as a clean safety profile and efficacy comparable to the two approved small molecules. The data vaulted over that bar. Astellas linked (PDF) one of the small molecules, Veozah, to placebo-adjusted reductions in hot flash frequency of 2.1 and 2.6 at Week 4 of its two phase 3 trials. Bayer reported (PDF) placebo-adjusted reductions of 3.04 and 3.29 at Week 4 of pivotal studies for its small molecule, Lynkuet. At 5.3, the placebo-adjusted reduction in AbCellera’s trial comfortably cleared the standard set by the incumbents. Veozah and Lynkuet came to market based on evidence of their ability to reduce the frequency and severity of hot flashes. AbCellera’s phase 2 study covered both endpoints, with the Canadian biotech reporting a mean reduction in severity of 1.4 points at Week 4 on ABCL635, compared to 0.3 points for placebo. Again, the placebo-adjusted result compares favorably to data on Veozah and Lynkuet. Analysts shared Hansen’s enthusiasm for the data. The phase 2 results “firmly validate ABCL635 as a potentially best-in-class treatment,” BMO Capital Markets analysts said in a note to investors Monday. ABCL635’s apparent efficacy edge “is likely attributable to the higher dosing/target engagement the asset is able to reach vs. the oral agents due to its wider therapeutic index,” the analysts added. The analysts, who model $2.3 billion in unadjusted peak sales for ABCL635, flagged the safety profile as another positive of the phase 2 readout. While Veozah carries a boxed warning for liver damage, nobody on ABCL635 in the phase 2 trial had elevated liver enzymes or bilirubin values. If replicated in phase 3, the lack of a liver signal could allow approval without the monitoring requirements imposed on Veozah. Investors appeared equally enthused, sending AbCellera's stock up 32% to $9.21 in premarket trading Monday from a Friday closing price of $6.93. Next, AbCellera will collect the Week 12 data and talk to its advisors about further development. The results open up “a wide variety of possibilities of how we might take this forward into phase 3 studies to truly maximize the value of the asset and make sure that ABCL635 is able to demonstrate its differentiation potential,” Sarah Noonberg, M.D., Ph.D., AbCellera’s chief medical officer, told investors.
Feds investigating if captain of boat that flipped in New York Harbor was running illegal charter business
High Volume Robotic-Assisted Bronchoscopies Offer Patients Exceptional Expertise
Pennsylvania pulmonology team surpasses 1,300 procedures
Congressional Dems launch probe into efforts to deport U.S. military members
The Democrats said the apparent collaboration between DHS and the military to deport troops' families "raises both ethical and legal concerns"
Congressional Dems launch probe into efforts to deport U.S. military members
The Democrats said the apparent collaboration between DHS and the military to deport troops' families "raises both ethical and legal concerns"
Chicago Bears Sign Fifth DB Since Start of Training Camp
Chicago police investigate business robberies in Chicago's Southwest Side
In a competitive Maine Senate race, women voters could be the deciders
The race between Susan Collins and Troy Jackson is one of this year's most high-profile Senate contests. To win, both candidates will need support from an especially powerful voting bloc: Maine women.
Surprise nominees, candidate scandals scramble the battle for Congress
Unexpected primary results have complicated both parties’ paths to control of the House and Senate.
I'll continue playing, rest is selectors' call: Bhuvneshwar Kumar
The 36-year-old, one of Uttar Pradesh’s most experienced cricketers, continues to remain a key figure in Indian domestic cricket. He last played for India in 2022, featuring in both ODI and T20I formats. His last international appearance in Tests came in 2018.
Abandoned factories are being resurrected for the AI revolution
Nature Medicine Just Published the AI Mental Health Audit Framework the FDA Hasn’t Written Yet
Nature Medicine's clinically validated AI chatbot audit framework arrives as FDA still lacks generative AI mental health approval standards—here's what trial…
Aubrey Plaza welcomes first child with Christopher Abbott
The couple, who met as costars on the 2020 psychological drama “Black Bear,” have remained largely silent about their relationship.
Aubrey Plaza welcomes first child with Christopher Abbott
‘Parks and Recreation’ star Aubrey Plaza and ‘Poor Things’ actor Christopher Abbott just welcomed their first child together.
CCTV+: Int'l Congress of Basic Science opens in Beijing
BEIJING, Aug. 9, 2026 /PRNewswire/ -- The 2026 International Congress of Basic Science (ICBS) opened in Beijing on Sunday, drawing more than 1,000 participants, including scientists, researchers and young scholars from both China and abroad.