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A promising fatty liver treatment may raise cancer risk
A surprising new study reveals that blocking a supposedly protective enzyme, Caspase-2, could actually backfire—raising the risk of chronic liver damage and cancer over time. Researchers found that without this enzyme, liver cells grow abnormally large and accumulate genetic damage, leading to inflammation, scarring, and eventually tumors, especially with age. While inhibiting Caspase-2 may offer short-term benefits, such as reducing fatty liver disease, the long-term consequences appear dangerous.
Lessons from Binghamton led alumni award winner to public health
Clare Biging ’16 is an epidemiologist and public health advocate at the New York City Department of Health and Mental Hygiene.
Science diplomacy, research and global health
Nature Microbiology - As a young scientist from the global south, engaging in science diplomacy has brought greater purpose and meaning to my career, writes Delfina Fernandes Hlashwayo.
Science diplomacy, research and global health
Nature Microbiology - As a young scientist from the global south, engaging in science diplomacy has brought greater purpose and meaning to my career, writes Delfina Fernandes Hlashwayo.
Google Tested AI Headlines In Discover. Now It's Testing Them In Search
Google is testing AI headline rewrites in Search using similar language to the earlier Discover test that became a feature.
Alcaraz eyes clay court season after early Miami exit
World number one Carlos Alcaraz remained confident his game is improving despite a third-round exit at the Miami Open, and after a few days to reset he'll be turning his attention to the clay court season.My mind right now is to take some days off, to reset my mind, reset the batteries, be ready and in good shape for the clay season."
Carrie Anne Fleming, 'Supernatural' and 'iZombie' actress, dies at 51
Carrie Anne Fleming, who appeared on 3 episodes of 'Supernatural' as Bobby's wife Karen, has died. She was 51.
Samsung Brings AirDrop Support to Quick Share with Galaxy S26 Series
Samsung is introducing AirDrop support to the Galaxy S26 series, making it easier for users to share content between devices using Quick Share. The feature will begin rolling out from March 231, starting in Korea and expanding to more regions including Europe, Hong Kong, Japan, Latin America, North America, Southeast Asia, and Taiwan. AirDrop support […]
How the G.O.P. and Democrats Are Talking About the Surge in Gas Prices
Republicans have largely been on defense against Democratic criticism. Here are five arguments advanced by figures in both parties.
Luke Doncic facing suspension as Lakers oppose playoff-bound Pistons
The Los Angeles Lakers barely kept their winning streak alive on Saturday. They'll go for 10 in a row when they visit the Eastern Conference-leading Detroit Pistons on Monday.
Sunday Sports: Sackets hoops in the state finals, plus updates on SU sports
Here’s a recap of your North Country sports this Sunday.
This Couple Turned A Facebook Marketplace Side Hustle Into A Seven-Figure Business
When Harrison Gordon and Paige Sandher couldn't find a modular custom sofa that was also affordable, they designed their own. They built a fast-growing business around their idea.
Apple already has the perfect platform for deploying conversational AI
When Apple initially rolled out Apple Intelligence, the company was pretty openly against the idea of creating a Siri chatbot....
Jason Momoa forced to evacuate as devastating storm hits Hawaii
Thousands have been ordered to flee as the archipelago faces its most intense surge of storms in two decades.
Business closed after new Ohio law banning intoxicating hemp products went into effect
Senate Bill 56 grants law enforcement the authority to remove intoxicating THC products from unlicensed retail locations,
Fire destroys 30,000 square feet of Aledo plating business, no injuries reported
The Cowboys are making a mistake with this move
The Cowboys still have to find help at linebacker.
UFL team signs former Alabama high school, Crimson Tide QB
The Thompson High School alumnus had been scheduled to play in the Indoor Football League on Sunday.
Woman seeks help at Aurora business after suffering serious injuries in shooting
A woman collapsed inside an Aurora business while seeking help after she was shot Saturday night. Police are trying to determine what led up to it.
Arizona vs Utah State live updates: Prediction, how to watch March Madness Round 2 game
Folks were gushing about Jerrod Calhoun and Utah State's offense in Round 1. Arizona is a whole different obstacle. Follow March Madness Round 2 game.
Full 7-round Arizona Cardinals mock draft simulation
We have a new 7-round mock draft for the Arizona Cardinals.
Phillies pitcher Daniel Robert stable after second medical emergency in six months
Daniel Robert suffered a cardiac event Sunday — the second in six months — but was stable after his defibrillator activated
Michael McCarthy Considering Three Races As Options For Journalism's Return
After Journalism worked five furlongs in company Sunday at Santa Anita, trainer Michael McCarthy said he is looking at three potential races to kick off the colt’s 4-year-old campaign. Journalism could return in either the Oaklawn Handicap (G2) or Ben Ali (G3) at Keeneland, both on April 18, or ...
Federal union says 'untrained' ICE agents shouldn't replace TSA
President Donald Trump said he would tap ICE agents to run security at US airports as unpaid TSA officers stop showing up to work.
Student researchers bring Kentucky State University science to Posters-at-the-Capitol
With lawmakers just steps away, three Kentucky State University undergraduates presented research on cattle health, soil amendments and food safety at the Capitol Annex on March 5, bringing student-led agricultural […]
Welcome to allergy season. Here's how to protect yourself
Where you live, what you're allergic to and your lifestyle can make a big difference when it comes to the severity of your allergies.
Nevada Wins Temporary Ban on Sports Betting on Kalshi
The prediction-market platform must obtain state gambling licenses and prohibit users under 21 to offer such contracts, a state court said.
Goodyear 400 Live Updates, Leaderboard: Will Tyler Reddick Win 4th Race This Season?
Follow along here for live updates from Sunday's Goodyear 400.
Khloé Kardashian Recalls How Her Divorce from Lamar Odom Made Her ‘Obsessed’ with Leading a Healthy Lifestyle
Khloé Kardashian opened up about her relationship with diet and exercise on the March 18 episode of her podcast, ‘Khloé in Wonder Land.’ She said she became ‘obsessed’ with exercise after examining how her food choices were affecting her quality of life.
The Times' top 25 high school baseball rankings
St. John Bosco and Sherman Oaks Notre Dame remain unbeaten in high school baseball
Florida vs Iowa live updates: Prediction, how to watch March Madness Round 2 game
Defending national champion Florida didn't need a warm-up to get going in their NCAA title defense. Will Iowa provide any resistance in March Madness?
Your Thymus and Your Healthspan
Our thymus gland plays a central role in the development or our immune system, specifically for supporting T cell development (how these cells got their name, maturation and differentiation in the thymus) and discriminating between self and foreign, non-self antigen proteins with production of dendritic cells. As we age, our thymus gland shrinks—the process known as involution—with progressive change from spongy to fatty tissue, with loss of functionality. But this process, with respect to timeline and extent, markedly varies from one person to the next. And to make things even more complicated, our thymus gland anatomy and precise location in the chest also is highly variable. So the famous Frank Netter diagrams from the 1960s (such as at left below) don’t capture the remarkable heterogeneity that a random set of 12 chest CT scans (below at right). What I consider as 2 landmark papers in Nature this week (here and here) used AI to quantify health of the thymus in 2 large cohorts, and then correlate the metric to a broad array of health outcomes. In this edition of Ground Truths, I’m going to cover three questions: (1) How was thymus health determined by AI?; (2) How is thymus health linked to key clinical outcomes? and (3) Are there ways we can promote a healthy (aka rejuvenate) thymus gland in our later years? Subscribe 1. How was thymus health determined by AI? This was accomplished by extensive work developing and validating an AI pipeline for 2 stages, the first for localization and segmentation of the thymus bed, and the second to quantify a digital marker, termed the thymic health score. There’s a lot to this algorithmic development, so I won’t go into all the details, but just provide a rudimentary outline of what was done. The 1st stage used supervised learning with 2 radiologists reviewing 2,461 chest CT scans. That work trained a 3D U-Net model to automatically identify the thymic bed’s 3D cropped region using center of mass coordinates, which reached 99.8% accuracy. The 2nd stage used a foundation model that was pre-trained with SwAV (which stands for Swapping Assignment between multiple Views), a self-supervised model, that generated a high-dimensional thymus representation of 4,096 features. That compares to the radiology reductionist and subjective scoring of 0 to 3 where 0 means the thymus is fully degenerated and fatty, and 3 is considered dense, intact glandular soft tissue. Notably, the self-supervised learning (SSL) performance was superior to supervised (AUC ~0.75 vs 0.55, respectively) reflecting the shallowness of the 0-3 classifier vs SSL’s holistic, self-taught AI. The thymic health score ranged from 0 to 100, with the highest number indexed to fully preserved thymic health. The algorithmic work extended to explainability with both Shapely value distribution, meaning the model was holistic not relying on any “magic” pixel, and occlusion sensitivity, demonstrating the model’s performance was not affected by ribs, sternum, lung tissue, but rather focused on the thymic bed directly. Below are a few saliency maps from the occlusion sensitivity that indicate the thymic bed focus, not affected by neighboring structures, using the jet color scale. Now the AI was ready for processing ~25,000 CT scans, each over 30 MB files, from the 2 large participant cohorts to provide a thymic health score, it did so in less than 14 hours, which is less than 2 seconds per scan! Share 2. How is thymus health linked to key clinical outcomes? The two cohorts were the National Lung Screening Trial, NLST (N=25,031) and the Framingham Heart Study, FHS (N=2,581) each with baseline demographics and long term follow up of >12 years for health outcomes. From the NSLT, you can see below that increased age and body-mass index were correlated to reduced thymic health. And, overall, men had reduced thymic health scores compared with women. There are a lot of graphs in the paper for outcomes, for both the NLST and FHS cohorts. To simplify the major outcomes, below is a composite Figure with striking reduction of all-cause mortality and for the different causes of death. The results were consistent between the 2 cohorts. For example, the cardiovascular mortality hazard ratio average was 0.57 in NLST and 0.38 in FHS (weighted to be 0.53 for the aggregate). The reduction of mortality also extended to digestive diseases and pulmonary disease (data not shown below). Lung cancer incidence was reduced by 36% for high vs low thymic health (Figure below, with a panel -incidence and b panel-mortality, adjusted for age, sex, BMI, smoking status). Notably, there was a smoker’s paradox: lower incidence and improved survival for lung cancer in smokers who had a high thymus health score. Smoking was associated with lower thymic scores whereas alcohol was not. Higher thymic health was linked to higher HDL cholesterol, lower triglycerides, lower fasting blood glucose, and lower systolic and diastolic blood pressure. Inflammation biomarkers, such as C-reactive protein and interleukin-6, were elevated in the people with lower thymic health scores. In their second paper, the same team looked at the relationship between thymic score and outcomes for 3,476 patients receiving cancer immunotherapy. The non-small cell lung cancer progression-free survival was reduced in patients with low thymic health score. A parallel relationship for survival was seen for other types of cancer including melanoma, breast, and kidney with a 44% lower risk among high thymic scores (Figure). A similar pattern was seen with different immune checkpoint inhibitors. The thymus health score outperformed programmed death ligand-1 (PD-L1)and tumor mutation burden (TMB) assay of the tumor and was an independent prognostic marker of progression-free survival. In this dataset, a direct connect with thymus score and adaptive immune function was noted with a correlation before cancer treatment for both T-cell diversity and thymus T-cell production (a metric known as T cell receptor excision circles). Thymus Removal Study There is a highly relevant citation about thymus function before moving onto ways to rejuvenate it. In 2023, a very important study of thymus removal during cardiothoracic surgery was published, with 1146 patients undergoing thymus removal vs 1146 matched controls (mean age 55 years). The adverse outcomes for thymus removal were striking, with a 2.9 higher risk of all-cause mortality and doubling of cancer incidence, 1.5 fold increase in cancer mortality, and 1.5-fold increase in autoimmune diseases. The immune function showed marked compromise after thymus removal, as reflected by CD4+ and CD8+ T cells (Figure below) Share Ground Truths 3. Are there ways we can promote a healthy (aka rejuvenate) thymus gland in our later years? In recent months we’ve learned a lot about the process of thymus involution and the pathways by which this may be modulated. Thymus involution is primarily due to loss to thymus epithelial cells (TECs) and there are 2 subtypes with different functions: the cortical, responsible for positive selection of T cells, and the medullary, for negative selection. When adipose tissue infiltrates the thymus, thymic adipocytes are pro-inflammatory, knocking out T-cell output. Likewise, systemic inflammation, or “inflammaging,” from smoking, obesity, and chronic stress promote thymic adipocytes. Now, from preclinical studies, we know about key pathways that account for these processes. Historically, back in 2014, FOXN1 was recognized as a single master transcription factor essential for TEC function, with studies in mice with forced FOXN1 upregulation leading to thymus regeneration. That laid the foundation for potential regrowth of quiescent thymus cells. It took awhile to find pathways to accomplish this goal and to even refute its role as the master regulator. The Liver-Thymus Axis Feng Zhang and his team recently showed that injection of an mRNA vaccine to the liver encoding DLL1, IL-7 and FLT3-L in combination, factors known to support thymopoiesis (Figure), successfully enhanced immune function in aged mice. However, the effect was transient. The FGF21 Story Two reports in 2025 addressed the thymus gland’s production of FGF21, a growth factor (fibroblast growth factor 21) and its control of thymus involution. This growth factor is also produced by the liver, but it doesn’t have impact on the thymus in aged rodent models. In contrast, The liver’s hepatocyte growth factor (HGF) has been shown to reverse senescent TEC structural changes. Growth hormone stimulates production of insulin growth factor-1 (IGF-1) in the liver and the thymus. Two small studies in human participants (TRIIM, for Thymus Regeneration, Immunorestoration, and Insulin Mitigation) of 6 and 50 people, respectively, treated with combined human growth hormone, metformin and DHEA, suggested the potential of slowing epigenetic aging and improving thymus mass and function. But the combination of drugs, small sample, and lack of controls make conclusions murky. Increased thymus FGF21 led to increased CD8 T cells in old mice and extended healthspan and improved physical performance. Building on the previous FOXN1 data, ablation of β-klotho, the obligatory co-receptor for FOXN1, accelerated thymic aging. The benefit to FGF21 was confirmed in a companion paper using an FGF21 knock-in mouse model showing thymus enlargement and increased TECs throughout the lifespan. (schematic Figure below). The accompanying editorial for these 2 papers speculated: “The proposed link between age-associated thymus involution and organismal aging is intriguing, and suggests we might seek to achieve systemic rejuvenation by counteracting thymic involution.” Other Factors Lessons from the Axolotl (Mexican Salamander) In an elegant set of experiments of the axolotl (Figure), known for its complete thymus regeneration after total surgical removal, mediators were identified. Surprisingly FOXN1 was dispensable. But midkine, a growth factor, appeared to be the driver, the initiator of thymus cell growth, survival, and repair. Other components that contributed were Postn+ (periostin-expressing mesenchymal niches) and Ccl19, a chemokine protein from the bloodstream. RANK and RANKL RANK (receptor activator of nuclear factor κB its ligand (RANKL) have been considered key regulators of medullary TECs. In a study of both aged mice and human thymus cell cultures, their key role was confirmed, with multiple benefits of resorting TEC function, recruitment of progenitor cells, and T cell development. Subscribe Summing Up This body of work strongly supports the health of the thymus gland as a critical regulator of human healthspan, not just a correlate or link. The new landmark studies are reinforced by the regenerative biology experimental models that have shown, via an array of mediators, that healthspan of aged mice is at least in part dependent on thymus gland function and its critical role for maintaining adaptive immunity. It sure seems that we’d be better off having an immune reservoir of naive T cells instead of a profile in older adults of exhausted, low quality, memory T cells, with a senescent phenotype. It is striking that we ignored the importance of the thymus gland for many decades. A wake-up call was the results of the thymectomy matched control study reviewed here, with the opposite of high thymic health score improved health outcomes. The convergence of AI and healthspan here is notable. The exceptional and laborious work for developing and validating (no less explaining) the AI to quantify thymus health set the foundation for probing the connect the major health outcomes in two cohorts with extensive follow-up. We’ve never had a way to meaningfully quantify the thymus gland before, so this represents important leverage of supervised, self-supervised, and transformer models. The study wouldn’t have been possible without AI. And it begs the question as to whether there are ways we can maintain our thymus at a high health score. But it’s not so simple to rejuvenate our thymus. There are multiple risks including the induction of autoimmunity, increasing the risk of cancer, and inducing a pro-inflammatory state. For example, factors that increase TEC proliferation could compromise the medulllary negative selection process and leak out auto-reactive (self-attacking) T cells. Thymic cells could be induced to proliferate, but we know, for example, that growth hormone and IGF-1 are associated with an increase risk of cancer. If thymus rejuvenation doesn’t clear out the accumulated senescent cells in older adults, then inflammation within the gland could block the production of TECs. Keeping these risks in mind, we now have identified many ways to keep our thymus healthy as we age that undoubtedly will be tested in clinical trials going forward. Ultimately, the benefit-to-risk tradeoffs will be defined. In the meantime, we have desperately needed an immunome. As I’ve stressed in multiple prior Ground Truths, we have no test in the clinic to assess a patient’s immune status! It was very encouraging for me to get an email from Hugo Aerts, the senior author of the landmark papers in the days after they were published: “I also wanted to say that your Substack on “Why We Need an Immunome” was inspiring for this work. We found it a very compelling perspective and greatly enjoyed reading it.” Just having an assessment of a person’s immune status via a chest CT scan, with millions of these performed per year, might help in guiding the right immunotherapy for cancer (e.g. more intensive, combinations for those with low thymic health scores) and help define people who are increased risk for age-related diseases of cancer, cardiovascular, and neurodegenerative. The main theme of Super Agers is that we now have many layers of data (genetics, proteins, biomarkers, organ clocks that can be integrated via multimodal AI) for us to define a person’s specific risk decades before one of these age-related diseases leads to symptoms, enabling prevention. From the new studies this week, we can add thymus health score as yet another way to understand a person’s risk, a window into their adaptive immune system and healthspan. And perhaps someday we will be able to safely rejuvenate the thymus, or maintain its health through one’s life, and use the thymus health score to monitor. NB: I wrote this post (No A.I.) A Quick Poll Loading... ********************************************************************* Thanks to Ground Truths subscribers (now > 200,000) from every US state and 212 countries. Your subscription to these free essays and podcasts makes my work in putting them together worthwhile. Please join! If you found this interesting PLEASE share it! Share Ground Truths Paid subscriptions are voluntary and all proceeds from them go to support Scripps Research. They do allow for posting comments and questions, which I do my best to respond to. Please don’t hesitate to post comments and give me feedback. Let me know topics that you would like to see covered. Leave a comment Many thanks to those who have contributed—they have greatly helped fund our summer internship programs for the past two years. It enabled us to accept and support 47 summer interns in 2025! We aim to accept even more of the several thousand who will apply for summer 2026.
Fear of immigration enforcement in NC keeps immigrants home, hurting Latino-owned businesses
Are spring temperature swings hurting your health? Yes, here's how
Weather swings affect your physical health in a variety of ways.
Immigration crackdown impact on local Latino-owned businesses
Latino business owners told WRAL News that fear and uncertainty following a nationwide crackdown in immigration enforcement are keeping some families out of public spaces, leaving small businesses struggling to survive. This story was written by Oriana Torre, a senior graduating journalism student at the University of Florida, participating in the CBC-UNC News Media Multiplatform Fellowship.
LISTEN LIVE: Supreme Court considers late-arriving mail ballot laws in case that may affect midterms
Mississippi State Health Officer Dr. Daniel Edney, a Vaccine Proponent, Is Under Consideration to Lead the CDC
Dr. Daniel P. Edney, Mississippi’s state health officer and head of the Mississippi State Department of Health, is now under serious consideration to lead the CDC.
Kentucky vs. Iowa State odds, time, March Madness predictions: 2026 NCAA Tournament picks from proven model
SportsLine's model has revealed its Kentucky vs. Iowa State picks for the NCAA Tournament 2026 second-round game on Sunday
What’s happening in Vegas arts entertainment this spring
Festivals, concerts, sporting events and more: Make plans with our entertainment calendar.
Breaking down Bills’ selections in latest NFL mock drafts
According to the latest NFL mock drafts, the Bills could go wide receiver, linebacker, safety, or defensive linemen at pick 26.
Top 5 states with the highest number of safe hospitals, according to new report
Trump mocks 'discombobulated' Schumer over Democrats' near gaffe on funding ICE
President Donald Trump mocked Chuck Schumer after the Senate minority leader accidentally said "We must fund ICE" on the Senate floor amid the DHS funding shutdown fight.
Bucket hats and home run chains: Getting decked out for baseball season at Poor Boys Sports
From shirts featuring new players to hats in every color, Poor Boys Sports has all your Orioles merch needs for Opening Day.
30 Must-Have Gadgets For Every Room In Your House
Prepare to power up your homes, my friends!
Far-left activists stay in 5-star Cuban hotel as island suffers total blackout
CodePink sponsored flights to Cuba to protest President Donald Trump's sanctions, but the group faced backlash for staying in luxury hotels.
Chiefs’ 2026 NFL Mock Draft roundup after NFL Free Agency
A closer look at the Chiefs’ 2026 mock draft outlook after free agency, with linked to edge help, cornerback, and offensive line support.
Wake County childcare centers take preventive measures as measles cases rise
You're Incredibly Smart If You Can Answer Even ONE Question On This Science Quiz
It's time to channel your inner Bill Nye.
The '80s Car Feature That Would Fit Perfectly In The AI Hellscape Of Today
The '80s car feature that would fit perfectly in the AI hellscape of today is Chrysler's Electronic Voice Alert that gave drivers warnings by speaking to them.
Arsenal vs. Manchester City live stream: How to watch EFL Cup final, odds, start time
This is Pep Guardiola's best chance at a trophy this season, and perhaps shift the momentum in the Premier League
Fitchburg Public Library hosts Wisconsin Film Festival preview
FITCHBURG, Wis. — The 28th Wisconsin Film Festival is coming up in just a few short weeks, and a local library is helping get the word out.
Science Central: Planetarium opens this week
Wednesday at 10:30 there will be a ribbon cutting unveiling the 1,830-square-foot planetarium features a 21-foot-high, 28-foot-wide dome.
Treasury secretary defends U.S. military actions in Iran: 'Sometimes you have to escalate to de-escalate'
Scott Bessent said "all options" were on the table to secure Kharg Island.
Sebastian Kehl exits role as Borussia Dortmund sporting director
Borussia Dortmund sporting director Sebastian Kehl is leaving the team with immediate effect as the club undergoes a major shakeup after what will be a trophyless season.
'Saturday Night Live UK' aims to take a comedy hit across the pond. The first verdicts are in
A British version of “Saturday Night Live” has debuted to largely positive reviews. The first episode of “SNL UK” was hosted by Tina Fey, a veteran of the American show, and stuck closely in...
\'Saturday Night Live UK\' aims to take a comedy hit across the pond. The first verdicts are in
A British version of “Saturday Night Live” has debuted to largely positive reviews. The first episode of “SNL UK” was hosted by Tina Fey, a veteran of the American show,
Apple Has Released More Than 10 Products and Accessories This Month
It has been a busy March for Apple, which has unveiled more than 10 products and accessories this month. However, aside from the all-new MacBook Neo and Studio Display XDR, the devices received faster chips or new colors and little else.
Nashormeh N. R. Lindo wears colorful dress to Oscars after-party
Lindo attended the after-party with her husband and supporting actor nominee for "Sinners," Delroy Lindo.
Third-generation cafeteria owner won't force his 4 sons to take over
Michael Greene, who runs Matthews Cafeteria, shares the highs and lows of managing a family business, and why his kids may not take over one day.
Square Enix announces it will integrate Google’s generative AI Gemini into popular online game Dragon Quest X
Square Enix has found a use for Google’s generative AI Gemini and will be putting it to use in the popular online game, Dragon Quest X. Gemini will be used in-game as a feature that allows players to…
Oscar-Winning Alumnus Returns to Pasadena’s ArtCenter for Entertainment Design Expo
One week after winning the Academy Award for Best Animated Feature, KPop Demon Hunters co-director Chris Appelhans returns today to ArtCenter College of Design, the Pasadena campus where he studied illustration, for the college’s third annual Entertainment Design Expo. The expo, known as ENTX, opens the Hillside Campus to the public for a full day of gallery exhibitions, game playtesting, animation screenings and interactive experiences featuring work from more than 200 ArtCenter students and alumni. General admission is free with advance registration. Two industry panels — including Appelhans’s talk — require $15 tickets. Appelhans, who graduated from ArtCenter with a bachelor of fine arts in 2002, co-directed KPop Demon Hunters with Maggie Kang. The animated film, produced by Sony Pictures Animation and released on Netflix, became the streaming platform’s most-watched film in history, according to Netflix, and swept awards season with wins at the Golden Globes, the Annie Awards and the Grammys before taking the Oscar on March 15. His talk and audience Q&A is scheduled from noon to 1 p.m. in the Ahmanson Auditorium. Doors open at 11:30 a.m. The film’s ArtCenter ties extend beyond its co-director. Art director Angela Sung, cinematographer Gary H. Lee, visual development artist Celine Kim and painter Simon Baek are all ArtCenter graduates who worked on the production, according to the college. The free portions of ENTX include a concept design showcase, a production design gallery, a model gallery, a stop motion studio preview, an alumni gallery and a KPop Demon Hunters fan art gallery. Visitors can also playtest games designed by ArtCenter students. An Animation Shorts Showcase runs from 2 to 3 p.m. and includes “Boy, I’m Scared,” a capstone short by ArtCenter graduate Lindsey Tenaglia that was named a semifinalist for the 2025 Student Academy Awards in the animation category. Also screening
Acuff scores 36 as Arkansas holds off No. 12 seed High Point 94-88
Two of the highest-scoring teams in the nation combined on a back-and-forth affair that featured 15 lead changes and six ties.
Core operating profit rises 4% as net profit holds steady, with full-year dividend maintained at HK35 cents
March 22, 2026 -- The Hong Kong and China Gas Company Limited (stock code: 0003, hereinafter referred to as “the Group”) has announced its 2025 ...
UF students celebrate ‘women supporting women’ through new mental health group
According to the Healthy Minds Network’s data interface, a little more than one in three female college students suffered from anxiety in 2025, compared to a little under one in four male students.
A secret weapon to fight carbon emissions was just discovered: Beavers
A new study in Switzerland finds that beaver-built wetlands can trap and store large amounts of carbon, offering a low-cost boost for restoration and climate resilience.
AI was everywhere at gaming’s big developer conference
Developers say it removes the craft from making games.
Pompey's hopes of staying up now unsure
BBC Radio Solent commentator Andrew Moon gives his thoughts following Portsmouth's 6-1 defeat at Queens Park Rangers in the Championship.
Golden Knights intent on igniting sluggish offense vs. Stars
With 12 games left in the regular season, it's fair to say that things are trending in the wrong direction for the Vegas Golden Knights.
German club Borussia Dortmund parts ways with sports director Kehl
German football club Borussia Dortmund said on Sunday it is ending its collaboration with sports director Sebastian Kehl with immediate effect.
How to reduce stress
Simple lifestyle habits and professional support can reduce how frequently stress occurs.
The Best Subscription-Free Home Security Cameras I've Tried
You don’t have to upload your video to the cloud or pay a monthly fee to secure your home. These security cameras record locally.
Margaret Cho on comedy, politics, and life in Hollywood
Comedian and actress Margaret Cho discusses her penchant for tackling political themes in her performances, evident in her upcoming tour, "Choligarchy,” coming to the Englert Theatre Friday, March 27.
Girls' basketball coach of the year: Alicia Komaki of Sierra Canyon
She came up with a winning formula to defeat Etiwanda and No. 1 Ontario Christian in the Southern Section Open Division championship.
A tribute to Scott Ostler, columnist, colleague, friend and sports wit
In Bruce Jenkins’ experience, there was never a teammate quite like fellow San Francisco Chronicle columnist Scott Ostler, who retired last week.
Lancaster County public sales: March 22, 2026
Beiler-Campbell Auction Services conducted a public auction of real estate March 9 for Stanley and Debora Miller at 2788 N. Colebrook Road, Manheim. A four-bedroom house with attached garage and
The Times' 2025-26 All-Star boys' basketball team
A look at the Los Angeles Times' 10-member All-Star boys' basketball team for the 2025-26 season.
Give Your Phone a Huge (and Free) Upgrade by Switching to Another Keyboard
Change up the default keyboard in Android and iOS and feel the benefit.
Dynamax Regice Max Monday: Event Guide
Max Monday features a different Pokémon in power spots for the whole day. Regice Max Monday takes place on March 23rd, 2026. This Max Monday is the fourth March Pokémon, and it is the debut of the legendary Ice Pokémon Dynamax Regice! Dynamax Regice is a Tier 5 Max Battle in Pokémon GO. It will cost […]
I'm glad my daughter was rejected from an Ivy League college
My daughter had her sights set on Brown University, but the Ivy League rejected her. Thankfully, she went to Fordham where she found her true passion.
Column: Republicans fearing a midterm rout revive Islamophobia as political strategy
The latest twist on replacement theory is the idea that white Americans are in need of saving from dark-skinned "others."
White House navigates vaccine politics, midterm risks in CDC director search
The Trump administration faces complicated political dynamics as it seeks someone to helm the key public health agency suffering a prolonged leadership vacuum.
FYI BR: Here are the upcoming Holi and Easter festivities in Baton Rouge
Plan for pictures with the Easter Bunny, festivities at the LSU Rural Life Museum and more.
Game Preview: Carolina Hurricanes @ Pittsburgh Penguins 3/22/2026
Who: Carolina Hurricanes (44-19-6, 94 points, 1st place Metropolitan Division) @ Pittsburgh Penguins (35-18-16, 86 points, 2nd place Metropolitan Division) When: 3:00 p.m. eastern How to Watch: Locally broadcast on Sportsnet Pittsburgh and FDSN South, streaming on ESPN+ Pens’ Path Ahead: Quality opponents await in the next week; the Pens host Colorado on Tuesday, an Avs team […]
White House navigates vaccine politics, midterm risks in CDC director search
The Trump administration faces complicated political dynamics as it seeks someone to helm the key public health agency suffering a prolonged leadership vacuum.
Andrej Karpathy says he uses an AI agent to control his pool
Andrej Karpathy said an AI agent named Dobby texts him whenever he gets a Fedex package and helps him control his spa.
Federal employee retired, works at TJ Maxx; feels happy, less stress
Karime Masson thought she'd keep working for the Social Security Administration until she was at least 62. But after a tough 2025, she retired early.
'Love Story' is Gen Z's analog dream life
The unplugged lives in "Love Story" feel remarkable to Gen Zers today. They're nostalgic for a time they don't even remember.
In the Fight to Defend the Amazon, This Indigenous Community’s Secret Weapon Is Science
In the copper-rich mountains of southeastern Ecuador, Shuar people are combining ancestral knowledge and modern science to protect their forest from a Canadian mining giant.
The war on Iran is in its fourth week. Here’s what to know
Three full weeks of the war the US and Israel launched against Iran have shocked the world oil market, pierced a sense of safety in parts of the Middle East, and claimed the lives of US service members and civilians in multiple countries.
Opinion | Are Ed Markey and other politicians hooked on power?
Can neuroscience explain why politicians like Bill Galvin won’t quit?
David Suzuki at 90: A life in science, and a warning still unheard
With ninety laps around the sun, David Suzuki reflects on a lifetime of science advocacy and environmental work. Despite decades of effort, he warns that humanity may have already crossed a tipping point on climate change.
How crowd-control agents can affect health
Grieving mother Naomi White walked along Kennywood Boulevard on March 15 with dozens of friends and family members who had gathered to call attention...
Businesses worried as fuel prices rise
An increase in fuel prices amidst the US-Israel war with Iran is affecting businesses in the UK.
Chivas hold off Monterrey’s comeback to get another win
Chivas defeated Monterrey by a 3-0 score in match defined by the last play of the match.
A Grip on Sports: In a season when Gonzaga's defense was the driving force behind its success, the Zags couldn't get the one stop they needed
A GRIP ON SPORTS • After all the flotsam and jetsam is swept away, sometimes a college basketball game, an NCAA Tournament game, comes down to making one play. Saturday night in Portland, Texas did. And Gonzaga’s season once again fell short of its ultimate goal.
Can Manchester City's Guehi play in EFL Cup final?
Manchester City will be without a key defender for Sunday's final at Wembley against Arsenal.