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Seattle World Cup match brings fans, Pride weekend, and global politics together
The World Cup’s stop in Seattle has already delivered packed streets, record-setting business days and a surge of international energy around Lumen Field.
Healthcare AI Leaders Are Rapidly Trying To Outmaneuver Skyrocketing Memory And GPU Costs
Compute power has become one of the most crucial components of the healthcare delivery cycle.
Carolina Reportedly Shopping Rookie Defenseman Alexander Nikishin
Stung by high contract demands and defensive inconsistencies, the Stanley Cup champions may trade their offensive blueliner to land a multi-time Vezina winner for the crease.
Ohio State Buckeyes projected to land elite offensive lineman
Ohio State sits on the cusp of another top-5 recruiting class, and the Buckeyes could be receiving even more good news this weekend. Four-star Jackson (Miss.) offensive lineman Caden Moss is set to commit Friday night, and the Buckeyes are surging late as the favorite to land him. Over the past 24 hours, Rivals national […]
Federal health agency cancels most of its teen pregnancy prevention grants
A spokesperson for U.S. Health and Human Services confirmed to Stateline on Friday that the agency is canceling 53 out of 67 grants, worth about $68 million, under the Teen Pregnancy Prevention Program, affecting grantees in more than two dozen states.
'The Invite' review: Olivia Wilde's sex comedy is outrageous fun
Seth Rogen, Penélope Cruz, and Edward Norton dazzle as flirty neighbors.
Barker reclaims title at National Road Championships
Megan Barker reclaims her British elite women's circuit race title as the second day of the National Road Championships produces its second Welsh winner.
World Cup 2026 Round of 32 tracker: Who’s qualified, who’s eliminated and who’s still alive
WATCH: Trump receives report from Religious Liberty Commission in the Oval Office
A new report by a Trump administration commission suggests replacing the idea of separating church and state with the idea of building bridges between them.
The 5-Question Org Chart Audit I Run Before Scaling AI Across a Business
AI success depends less on the technology and more on the organization behind it. These five questions help leaders identify the structural barriers that prevent AI from delivering real business impact.
Trump tries out midterms message that focuses on ‘communists’
Trump warned an audience of religious conservatives that communism is spreading in the U.S., a new theme for his midterm campaign.
Hisense U7SG 4K TV: Modern Entertainment for the New Age
The Hisense U7SG 4K TV delivers stunning MiniLED visuals, 165Hz gaming performance, and Dolby Vision IQ for an immersive entertainment experience.
Factory Entertainment Announces Three More STAR TREK Collectibles, Including Gold-Pressed Latinum Bars
Factory Entertainment today unveiled three more STAR TREK replicas, including bars of gold-pressed latinum and Eline’s necklace from “The Inner Light”
Evoke Entertainment Signs Tribeca-Honored Filmmaker Elisee Junior St. Preux
EXCLUSIVE: Evoke Entertainment has signed Haitian American filmmaker Elisee Junior St. Preux, whose debut feature The Tropic Sun and His Eyes world premiered in Tribeca’s Viewpoints section and earned...
Elisee Junior St. Preux Signs With Evoke Entertainment (EXCLUSIVE)
Filmmaker Elisee Junior St. Preux has inked with Evoke Entertainment for management, Deadline can report exclusively.
THE NEXT GENERATION TAKES THE TRACK: COPACI AND PANAM SPORTS LAUNCH ELITE CYCLING DEVELOPMENT CAMP IN TRINIDAD AND TOBAGO
Young cyclists from across the Caribbean are gathering in Trinidad and Tobago […]
Paxton’s support for IVF highlights broader divide among GOP
Anti-abortion activists believe life begins at conception, so many oppose IVF because it often destroys some embryos.
New feed trailer expands feed delivery opportunities
Delivery of bulk feed produced at the Iowa State University Kent Feed Mill and Grain Science Complex to Iowa State’s animal science farms is now possible, thanks to a new high-tech feed trailer.
Summer Science Program
Explore information about the Summer Science Program at Arkansas Children's Hospital, a career readiness program for college students, including eligibility and how to apply.
Morocco jails 29, including politicians and sports figures, in drug trial
Casablanca court delivers landmark verdict in 'Escobar of the Sahara' case: up to 12 years for top figures.
ECU Health announces 2026 Board Quality Leadership Award winners
ECU Health Board Quality Leadership Award winners were recognized for delivering exceptional experiences and advancing patient outcomes.
Why Your Nighttime Dreams Are So Weird—Science Finally Has the Answer - Futura-Sciences
The Secret Life of Dreams: Not Just Random Nonsense Remember the dream you had last night? Maybe you’re left with just a trace—a sweet feeling, maybe, or a strange discomfort. But there’s rarely a story you could actually retell. Because, in the end, a dream is a deeply personal experience....
Athlete of the Year finalist: Penn Manor standout provided the power for Comets in 3 sports
Anneli Starry didn’t know what she had in Joelle Kroesen. The Penn Manor girls lacrosse coach labeled the then-freshman as a swing — an athlete who is rostered on two
Council Explores AI, Quality Improvement and Patient Safety to Advance Community Health
The MHA Council on Health Access and Community Impact held its final meeting of the program year June 4 to examine emerging opportunities and challenges shaping healthcare delivery and advancing community health.
Music Legend Axes Shows After Onstage Health Scare
Lionel Richie was hospitalized on the opening night of his tour with Earth, Wind & Fire after feeling dizzy on-stage.
‘Snapdragon 8 Elite Gen 6 Pro’ needed more words to prove its power, three other flagship chips coming
Qualcomm’s Snapdragon chipset lineup is eternally confusing, with slight variations generating new names and options that aren’t all that different....
What New York’s primary upheaval means for Democrats: Join Friday’s Whole Hog
Democrats are still feeling the political aftershocks of New York’s primaries on Tuesday night, including New York City Mayor Zohran Mamdani-backed victories. What could it signal for the party? Pl…
Why Pollinators Matter for Human Health | Johns Hopkins Bloomberg School of Public Health
New research shows that wild insect pollinators play a critical role in nutrition and livelihoods.
Starlink veterans launch startup to broaden megaconstellation ownership
Former SpaceX engineers who helped build and scale Starlink have launched a startup aiming to deliver megaconstellations for governments and companies seeking more control over space-based infrastructure.
Sweden and WHO launch new long-term initiative to transform Ukraine’s health system
WHO and the Swedish International Development Cooperation Agency (Sida) have launched a new multi-year cooperation project to support the long-term recovery and transformation of Ukraine’s health system. The new project, “Ukraine’s Health System Transformation Initiative: Strengthening Health Governance, Health Financing and Service Delivery for Long-Term Recovery”, was launched at the Ukraine Recovery Conference 2026 in Gdansk, Poland on 26 June, and will run from June 2026 to 2029. Sweden will contribute approximately US$ 26 million (240 million Swedish krona) to support this project. This contribution forms part of Sweden’s broader support to Ukraine through the Team Europe approach, which brings together the European Union, its Member States, and key partners such as the European Commission’s Directorate-General for Enlargement and Eastern Neighbourhood and Enabel, and WHO as lead health agency, to support Ukraine’s recovery, reform agenda and European integration.“Ukraine’s health recovery cannot be measured only by what is rebuilt, but by whether people can count on the health system when they need it most. The scale of the task is immense, with health reconstruction and modernization needs estimated at US$ 19.4 billion over the next decade. Sweden’s US$ 26 million contribution to Ukraine’s Health System Transformation Initiative is a timely investment in the institutions, financing and services that will support Ukraine’s long-term recovery and European integration. WHO remains a trusted partner of the Government of Ukraine in advancing this process. I am deeply grateful to Sweden for its consistent support and partnership,” said Dr Hans Henri P. Kluge, WHO Regional Director for Europe. More than 4 years of war have placed unprecedented pressure on Ukraine’s health system, creating 3 interconnected challenges. The first is responding to the immediate consequences of the war and the urgent health needs of the population. The second is recovering and modernizing health services today. The third is continuing reforms and aligning the health system with European standards in the context of Ukraine’s future accession to the European Union. The war has led to large-scale population displacement, an increasing need for trauma care and rehabilitation, and shortages of health workers. High out-of-pocket payments in Ukraine make access to health services more difficult. Around 46% of total health expenditure is paid directly by individuals, placing a significant financial burden on many households and underscoring the need for reforms in health financing. Older people, persons with disabilities, women, children and veterans continue to face the greatest difficulties in accessing health services. “Ukraine is demonstrating that health system transformation can continue even during war. Ukraine is also continuing to align its health system with European norms and standards. WHO is committed to supporting Ukraine on this journey. We provide technical support, help coordinate partners’ efforts and support the institutional changes needed to strengthen the system. We are grateful to Sweden for its support. Through this partnership, we can help Ukraine build a more resilient, accessible and people-centred health system,” said Dr Jarno Habicht, WHO Representative in Ukraine. About the Health System Transformation InitiativeThe new initiative will support Ukraine through 3 interconnected areas: strengthening governance and coordination of health sector reforms through more inclusive coordination platforms and structured policy dialogue; transforming service delivery by reinforcing a primary health care-centred model that integrates family medicine, nursing and midwifery; and improving financial sustainability by supporting reforms that ensure the long-term viability of the national health system and reduce out-of-pocket payments for households. Overall, these reforms are expected to make the health system more coherent and easier to navigate, improve the quality and continuity of care, and ensure more equitable access to services, particularly for those who need them most. They will also support Ukraine’s progress towards a more modern health system aligned with European standards. “We are convinced that long-term recovery is not possible without strong, high-quality, person-centred health services that are accessible to everyone. Our partnership with WHO is designed to support deep and lasting systemic changes. Investments in human capital especially autonomous midwives, whose role for maternal, newborn and adolescent sexual and reproductive health cannot be understated, stronger governance, digital transformation and the financial sustainability of the health system are investments in Ukraine’s future. We are proud to support this process,” said Malin Perhult, the Head of the Ukraine Unit at Sida. Focus throughout implementation will be given to the most vulnerable population groups, including older people, women and children, and persons with disabilities, who have been affected by the war and face greater health-care needs. The initiative will be implemented in close cooperation with the Ministry of Health of Ukraine, the National Health Service of Ukraine, the Public Health Centre of Ukraine, regional authorities and international partners. This project will help Ukraine move towards a system where everyone can access the health care they need. It will strengthen primary care, make the health finance system more stable and predictable, and reduce the out-of-pocket costs that Ukrainians face when using health services. As a result, the Ukrainian health system will become more aligned with European standards and more sustainable in the long run.
Supreme Court rules in weedkiller cancer case
Dems want to unmask Eli Lilly's obesity drug user, a new genome-editing tool raises ethics questions, and more health news
Medical breakthroughs collide with the health system
The buzziest advances — like personalized gene therapies or AI-discovered drugs — may not deliver.
Louisville coaches can't afford to stay sidelined amid NCAA changes
The NCAA has brought college sports into instability, which is why coaches like Louisville's Jeff Brohm and Pat Kelsey have to be activists.
Notre Dame 2026 Player Profile: Wide Receiver Devin Fitzgerald
As the son of an NFL legend, this physical Arizona standout is already flashing elite route-running and contested-catch skills after a dominant spring debut in South Bend.
'The Vampire Lestat's Sam Reid on Magnus, Claudia, Sofia, and more
Would Lestat listen to Chappell Roan? Asked and answered.
‘The Hot Zone’ led me to work with Ebola patients. Now I have mixed feelings about the book
“The reality of Ebola is simultaneously less sensational and far more challenging than most people imagine,” writes Krutika Kuppalli.
Best Prime Day laptop deals: Save up to $970 on MacBooks, Windows PCs
Laptops are very expensive these days. These discounts help.
Slotkin says Democratic Party needs 'new leadership': 'Old models are no longer working'
Sen Elissa Slotkin calls for new Democratic Party leadership, saying old models no longer work and the party must simplify its message to win back voters.
EVA HENRY: Corruption resurfaces in Adams, Arapahoe County politics linked to One Main Street
Corporate dark money groups are funneling millions into eleven different races statewide.
Why Michelle Pfeiffer left her 'Grease 2' audition feeling 'so humiliated'
On the anniversary of 'Grease 2,' take a look back at what Michelle Pfeiffer said about her audition. It was humiliating.
It's Xbox's turn (again), as console prices keep going up
Microsoft announced a price hike for the Xbox Series consoles today, the third in little over a year. Effective August 1, the Xbox Series S, which launched in 2020 for $300, will cost $500 in the U.S. The Xbox Series X, which launched in 2020 at $500, will go for $800. This follows a round of PlayStation 5 price increases from Sony this spring, and a slow-motion increase for Nintendo’s Switch 2, which will kick in in the U.S. in September. (Mind you, there were also eight video game industry price hikes in six months of 2025). The chart up top shows the sudden ascent of console prices over the past year, a sudden surge in an already unusual hardware generation. Prices had been flat for years, now “up” is the new “flat.” Game console prices used to go down across the length of a console generation, but not this time around. Microsoft’s explanation for the new price hike today: We hoped another price increase would not be necessary, and we have spent the last several months working with suppliers on options. Unfortunately, console storage and memory prices have increased by more than 2.5x and we expect another doubling by the fall of 2027. The entire consumer electronics industry is struggling with the current components crisis, but the effects are particularly hard on consoles. Unlike phones, computers, speakers, and other consumer devices, consoles are typically not sold at a profit, but instead for less than they cost to make. This is an issue well beyond game consoles. Apple announced price hikes on its computers and tablets today as well. Game File is a reader-supported publication. To receive new posts and support my work, consider becoming a free or paid subscriber. Subscribe Item 2: Brutal Bungie cuts Bungie laid off “most” of its Destiny development team and some developers who worked on Marathon, the newest game from the struggling Sony-owned studio. A WARN notice issued by Sony to Washington State, where Bungie is based, tallied cuts impacting 292 workers, effective next month. That’s strictly for Bungie/Sony jobs in Washington and wouldn’t account for any elsewhere. The video I clipped below shows the redacted list of Bungie cuts filed to Washington State officials. As you’ll see, I had to scroll for a while… In a note emailed to PlayStation workers and published online, PlayStation game studios chief Hermen Hulst offered the following explanation for these latest cuts at Bungie: This is painful news, especially for talented colleagues whose roles have been eliminated. This decision was made only after extensive discussion and careful consideration, and I want to provide some context on how we arrived here. Over the past several months, together with Bungie leadership, we reviewed the studio’s long-term direction, development priorities, resource needs, and role within our broader portfolio strategy. We explored multiple alternatives before concluding that a reduction was necessary to align the studio’s resources with its current priorities and long-term goals. In 2022, Sony bought Bungie for $3.7 billion. The studio’s marquee game, the multiplayer live service shooter Destiny 2 was losing popularity at the time. Its next game Marathon, released earlier this year, has been well-reviewed but had a slow start. Bungie is renowned for making great shooter games, and Destiny fans have mourned the wind-down of Destiny 2. They’ve also expressed bewilderment over reports that Destiny 3 is not, per Bloomberg, immediately in the cards.
Generative artificial intelligence creates delicious, sustainable, and nutritious burgers
npj Science of Food - Generative artificial intelligence creates delicious, sustainable, and nutritious burgers
Joint statement – WHO/Europe and CCEE to collaborate on addressing health inequities and loneliness
WHO/Europe and the Council of Bishops’ Conferences of Europe (CCEE) officially signed a Letter of Intent on 23 June to establish a strategic partnership for promoting pan-European dialogue to reduce inequities, enabling every child and adult to live in health, safety and dignity.
New district leaders could take over Brooklyn Democratic Party
The current chair said she believes in "moving forward."
Kawhi Leonard Seeks Extension – But Not With Current Team
Kawhi Leonard has one year left on his current contract with the Los Angeles Clippers. He’s eligible to sign an extension this summer, and sounds like he’s willing to do get that done. The one caveat: The Clippers aren’t necessarily the team he wants to sign with. Leonard, who turns 35 on June 29, ...
New Orleans Pelicans Exercise Karlo Matkovic's Third-Year Option
The New Orleans Pelicans have exercised Karlo Matkovic's third-year option.
ESPN believes Detroit Lions have best weapons in NFL
ESPN’s Bill Barnwell believes the Detroit Lions have better offensive weapons than any other NFL team in 2026.
Neuroimaging utilization in emergency departments has increased year-over-year for a decade
Researchers believe their new data could be used to better inform staffing coverage in modern radiology departments.
Business Council deliberations continue with four bill drafts
Lawmakers on the Joint Appropriations Committee spent another day diving through the Wyoming Business Council’s dealings. This time, they also reviewed draft bills that would influence how the council operates.
UT Health San Antonio researcher receives $400,000 Komen grant to study therapeutic yoga for breast cancer survivors
Amelie G. Ramirez, DrPH, MPH, to work with Hispanics in South Texas Contact: Steven Lee, (210) 450-3823, lees22@uthscsa.edu Content provided by Cliff Despres SAN ANTONIO, June 25, 2026 – Amelie G. Ramirez, DrPH, MPH, a cancer researcher at UT Health San Antonio, the academic health center of The University of Texas at San Antonio, is […]
Less Islamism, More Nationalism
In Iran and across the Middle East, the bond between religion and politics is getting weaker.
Making Our Own Luck
We are cross-posting a piece that former NIH official Kris Willis wrote for Macroscience. Kris is now the President and Founder of the Woodley Park Institute, for which I’m a board member. Picking winners or hedging bets? Federal science agencies have long wrestled with the question of how to ensure their billions of dollars of grants and contracts result in maximum benefits for Americans. On the surface, it might seem that a goal-oriented, interventionist style of management would be the best policy: prioritize our most pressing problems and distribute funding accordingly.This top-down strategy creates a unique hazard, though: bad choices can send resources in the wrong direction, resulting in slow progress that impedes the delivery of tangible benefits to citizens. Moreover, if decision makers pursue an applied advance when the underlying scientific principles remain poorly understood, they risk costly failures and a loss of support for the research enterprise at large. Examples include Nixon’s 1971 War on Cancer, undertaken on the premise that a cure could be achieved in less than a decade, the drive to build an operational commercial fusion plant by the mid-1990s, and the National Plan to Address Alzheimer’s Disease, which failed to produce the effective treatments and prevention strategies promised by 2025. The contrasting laissez-faire approach is to hedge your bets. If the path to an advance is impossible to predict, then the wisest choice might be to distribute funding to as widely as possible. The main risk of this strategy is that spreading funding thinly may limit the resources available to the most promising research, resulting in the same negative outcomes as the interventionist approach: limited support for the most promising topics, slow progress, and delayed returns. In reality, at science agencies like the National Science Foundation and National Institutes of Health, program managers navigate between these two extremes, setting some funds aside to target high-priority areas and using the rest to cover the widest possible range of meritorious proposals. This middle path seems like the most rational way to proceed, but it still requires making choices. How much should be set aside for high priority topics? What should those topics be? How should we define merit? Expert opinion can provide a helpful guide, but leading experts can have remarkably different opinions about what matters and what should be prioritized. Moreover, experts and administrators alike can be risk averse, giving an edge to high-profile, well-established concepts. What’s really needed is a data-driven framework to help guide decision-making, one that doesn’t simply repackage prestige or incumbency. Recognizing breakthroughs years in advance Many breakthroughs fail to attract funding or recognition at the earliest stages of development. Katalin Karikó, for example, spent years struggling to win grants for work on mRNA that would eventually win her and Drew Weissman a Nobel Prize. Similar stories can be told about Jim Allison’s groundbreaking studies leading to the development of cancer immunotherapy, Stan Pruisner’s demonstration that prions can self-replicate without DNA, or Robin Warren and Barry Marshall’s proof that Helicobacter pylori, not stress, causes ulcers. Yet at some point, the scientific community recognizes and responds to transformative breakthroughs like these. How does that change happen? And what if science funders could identify the areas that are on the cusp of a breakthrough? Those questions led my collaborators and me to study how scientists responded to past breakthroughs. Based on patterns in that data, we developed a means of predicting future breakthroughs, using biomedicine as a proof of concept. It’s worth taking a moment to describe how our approach works. Briefly, our prediction process begins by grouping the 18 million or so peer-reviewed papers in PubMed, the authoritative database of biomedical research, into roughly 50,000 unique topics. A small subset of these topics are so widely acclaimed as breakthroughs that they have been recognized with a major prize like a Nobel or a Lasker Award. We theorized that studying the development of these outliers over time, especially before they gained acclaim, was the key to identifying future instances of them. After defining topics, we chose 21 representative breakthroughs and asked what they looked like before they won prestigious prizes. To answer that question, we re-ran our topic-mapping algorithm repeatedly, winding back the clock one year each time, stringing together the years to follow the progress of each field as it grew and advanced. We found that in each case, the years leading up to a discovery followed a pattern: a burst of papers on a new, rapidly evolving topic, many of which quickly became influential. These characteristics—the percent of papers that are new, the percentage of papers that are brought in from other topics, and the influence of each individual paper—can all be measured separately for any given topic. Together, they act as a predictive signal that is detectable an average of five years before a transformative discovery is made, and up to thirty years before the discovery receives a major prize. Scanning the current research landscape for topics that display this signal allows us to predict what work will likely produce a future breakthrough. Each year we analyzed includes four or five signals, a number that appears to have remained constant across a twenty year time frame. In their classic work on the sociology of science, Bruno Latour and Steve Woolgar established that the desire to participate in a major discovery is an important motivator for scientists as they consider whether they should take up (or abandon) a research problem. Although further work is needed, the simplest explanation for our results is that this behavior is widespread enough to detect at scale. A foundational advance, or something like it, draws the attention of scientists and causes them to change the direction of their research. They vote with their feet, staking their own reputation and careers by publishing on and citing the new idea. That upswell of interest is the foundation of our breakthrough signal. What kind of research does our model identify as a breakthrough? After building a model based on the patterns in our 21 preselected breakthroughs, we tested it by identifying all early signals of discovery from 1994 through 1997. Of the 18 signals we found in that time period, 17 can be traced forward in time to a breakthrough. Examples include super-resolution fluorescence microscopy (see the image above), the directed evolution of proteins and enzymes (Chemistry Nobel, 2018), and sequencing the human genome (National Medal of Science, 2008). The discovery of the role of leptin signaling in obesity is a particularly interesting case study. Around 1950, scientists noticed the existence of a type of lab mouse that suffered from a unique inherited form of obesity. When given the freedom to choose their own diet, these mice ate more than normal and preferred food that was high in fat. Researchers had few clues as to why the animals overate; early experiments pointed to the existence of a soluble ob factor found circulating in the bloodstream that regulated appetite, but its identity was unknown. In 1994, Jeffrey Friedman and colleagues identified and sequenced the ob gene, noting that the protein it encoded appeared to fit the profile of a circulating factor. A year later, a trio of high-profile publications demonstrated that ob was a hormone that regulated body weight and fat deposition by regulating appetite. One of these was co-authored by Friedman, who christened it leptin from the ancient Greek word for thin. Using our model, the data from 1996 make it clear this advance would become a breakthrough. Scientists had flocked to study the biology of the new hormone, generating the flurry of new papers and citations required to produce a signal. One of these demonstrated that serum leptin concentrations reflected the amount of adipose tissue in the human body, providing clinical validation of the earlier mouse studies. Before the identification of leptin, scientists were unable to point to a specific molecule that controlled appetite and adiposity, so that it was impossible to rule out non-physiological causes of obesity; its characterization fundamentally changed our concept of weight gain. In 2010, Friedman and fellow pioneer Douglas Coleman were awarded a Lasker for the discovery. Our work also identifies breakthroughs in clinical practice and behavioral and social sciences, even though these areas are less likely to draw the attention of major prize committees. One example that falls into this category is the introduction of endovascular aneurysm repair, a minimally invasive surgical procedure for the treatment of abdominal aortic aneurysm, a leading cause of death among Americans over the age of 65. Relative to the previous standard of care, it reduces in-hospital mortality by almost four-fold. In 2017, Timothy Chuter received the American College of Surgeons’ prestigious Jacobsen Innovation award for his multiple refinements to the technique. Another under-recognized breakthrough identified by our model is the development of standardized survey instruments to assess the quality of life for HIV+ patients. The antiretroviral cocktails introduced in the mid-1990s reduced AIDS mortality, but treatment came with serious side effects. The new evaluations showed that patients whose disease progressed had worse physical functioning than Americans with other chronic diseases, while those who were asymptomatic maintained a health-related quality of life on par with the overall US population. This evidence made it possible for patients and activists to argue that even in the absence of a total cure, and in spite of the side effects, alleviation of symptoms was a worthwhile priority for clinicians. My colleagues and I have failed to identify any significant recognition for the physicians and health policy experts who pioneered this advance, although in 2016, researchers called for the World Health Organization to set targets for good health-related quality of life as part of its framework to end the AIDS pandemic. From forecasting to funding How should science funders use our predictions? Any serious discussion of what we should do with this new capability needs to begin with an understanding of its limitations. We can’t (and shouldn’t) invest all of our resources in the small number of topics predicted to produce breakthroughs. Innovative new fields are born from existing ones; they rarely arise de novo. If funders don’t maintain a diverse portfolio, the breakthroughs of tomorrow will have no antecedents. Think of this as eating the seed corn, or killing the goose that lays the golden egg. There are also multiple goals of funding beyond basic scientific discovery, including translating discoveries into clinical practice, developing new technologies, supporting economic development, and training new scientists. The investments needed to accomplish these goals are likely different from those required to support emerging breakthroughs. Finally, we must be aware that we may not capture every instance of a breakthrough. The concept is fuzzy, and not every significant discovery is recognized with a major award. Further, breakthroughs are rare, meaning that our dataset is, by necessity, small. This makes formal estimates of accuracy challenging. Although our overall success rate appears to be high, any one signal may turn out to be a false positive. We found one apparent example: the development of the third generation COX-2 inhibitors, Vioxx and Celebrex, which were much celebrated in the early 2000s as effective but non-addictive pain relievers, meets all the algorithmic criteria of a breakthrough. Five years after it received FDA approval, researchers demonstrated that Vioxx was associated with serious cardiovascular complications, and the manufacturer voluntarily pulled the drug from the market. Celebrex remains available, although like other NSAIDs, it carries an FDA warning for increased cardiovascular risk. Decision makers who were overly focused on the breakthrough potential of this research might have wasted substantial resources nurturing an area that ultimately proved to be a failure—but so would those who relied on expert opinion at the time. That said, the potential benefits of funding the next mRNA vaccine or cancer immunotherapy years earlier than we might have are large. When we can’t assume the outcome of an action, it’s worth conducting an experiment. Can targeted support for areas that are poised to produce a breakthrough increase the return on scientific investment without cannibalizing future advances? With the necessary administrative infrastructure in place, conducting this experiment would be straightforward. First, identify all the breakthrough signals between 2018 and 2023, select half at random, and commit to a decade of investment. For biomedicine, a six year window should yield about 30 topics with the potential to produce a breakthrough. Providing strong support to half of these might be accomplished for $300 million a year. That’s roughly half of the recent annual budget of the NIH Common Fund or around 20% of the fiscal year 2025 budget for ARPA-H. After five years, then again at ten, compare to see which group — the one that was actively managed, or the control — produced more breakthroughs, and on what timescale. Although we used biomedicine as an example, the same experiment could just as well be run for physics, materials science, or any other discipline. Any attempt to undertake such an experiment should keep three points top of mind. First, we can predict the topic of future breakthroughs, but the people and vision for how to move the work forward are still important. In practice, this means success requires active program managers with the expertise to develop the science and the authority to do so, including by recruiting investigators. Second, we would be wise to learn from the failures of past attempts to fund transformative research. High among these are funding modestly repackaged work, confusing the genuinely novel with the merely unfamiliar, and relying too much on incumbent investigators. All of these risks can be mitigated by thoroughly and intelligently integrating high quality data into portfolio management. Finally, we need to have patience. Even with strong funding support, producing a breakthrough takes time. If supporting breakthroughs is the best way to nurture the birth of new fields, we also need to accurately describe and properly manage the other two stages, so that we invest wisely throughout the productive lifetime of ideas and divest once they reach the point of diminishing returns. We would benefit from more study of all of these phases, especially the transition from one to another. More research could answer questions like: When does a breakthrough become an established field? How do the availability of funding, the size and characteristics of the available workforce, and the accumulation of evidence that disagrees with prevailing models affect a field’s decline? Exactly how do old ideas give birth to new ones, and can we speed up the process? The more we understand about the dynamics of scientific progress, the better we can maximize the odds that our curiosity leads to results. I’d call that finding a way to make our own luck.
Trump budget request omits funds for L.A. fire relief, prompting criticism from senators
The omission is the latest strain in a yearlong standoff between California leaders and the Trump administration over federal disaster aid.
Officials offer lifeline to struggling French Quarter businesses
At least three businesses have closed due to ongoing construction.
Takeaways: Supreme Court hands Trump massive wins on immigration agenda
The Supreme Court’s conservative majority delivered President Donald Trump a pair of significant affirmations of his immigration policy Thursday, paving the way for the administration to effectively remove more than 1 million people from the US and keep many others from entering in the first place.
Prime Day ends soon: We found 125+ deals from Apple, Lego, Sony, Kindle, and more
Kindle e-readers, Apple Watches, and Samsung TVs are all highlights on day three of the Amazon sale.
If I were traveling, Anker is the only company I would trust with my life to keep my tech fully charged at all times — and 11 of its best items are on sale right now
Get these Anker products to keep your gear always charged!
Participating in heavy-contact youth sports, dropping out of sports linked to acts of violence
Contrary to popular belief, simply playing organized youth sports does not reduce the likelihood of committing violence in one’s lifetime, and in some cases, may increase it, according to a new study.The study, published online recently in the Sociology of Sport Journal, found that while most survey respondents — including those who played y...
Steam Summer Sale 2026 arrives: 10 hot video game deals
Do you like Star Wars? We have good news.
Adidas’ NIL pipeline is producing NBA rookies who already know the business
Mikel Brown Jr. reached the NBA with a head start few rookies have. Long before being selected sixth overall by the Brooklyn Nets at Tuesday’s NBA Draft, the 20-year-old guard had been embedded in Adidas’ ecosystem through a name, image and likeness deal that began in high school. “By the time our athletes walk across […]
http://democrats-energycommerce.house.gov/media/press-releases/pallone-opening-remarks-health-subcommittee-markup-15-bills
Energy and Commerce Committee Ranking Member Frank Pallone, Jr. (D-NJ) delivered the following opening remarks today at a Health Subcommittee markup of 15 bills:
Gov. Shapiro on Mamdani-backed wins in NYC: Candidates doing ‘performative politics’ must learn ‘how to deliver results’
Lionel Richie takes ill, cuts opening concert of tour short
The Rock & Roll Hall of Famer, who is 77, told his 10,000 fans he was feeling dizzy but performed for nearly an hour before leaving the stage.
This weekend in Clarksville: Science guy, rodeo, Nunsense, ‘How to Train Your Dragon’
From science to fantasy, from rodeo to religion, there's a range of stuff going on in Clarksville this weekend.
Supreme Court hands Trump two major immigration victories
Supreme Court rules migrants turned away at the border cannot apply for asylum and blocks TPS recipients from judicial relief in two major decisions.
Longtime Entertainment Industry Lawyer Joins Royalties Retriever SoundExchange
Michele Page, formerly of Peloton Interactive, arrives at a pivotal time for the nonprofit reeling from a court ruling that may impair its ability to sue on behalf of artists.
'The Bear' reheats 'The Pitt's nachos in a baffling Season 5: Review
How does the final course of "The Bear" shape up?
Federal court blocks Trump’s executive order limiting mail ballots
The ruling comes a month after another judge allowed Trump’s order to stand. The latest ruling sidelines major provisions of the order despite the earlier ruling.
Supreme Court sides with big business in Roundup cancer risk fight
The ruling is also a victory for the Trump administration and a defeat for the Make America Healthy Again movement.
GLP-1 and reduced cancer risk discovery earns UT Health San Antonio fellow prestigious Helio NextGen Disruptor Award
Colton Frisco Jones, MD, a 2nd-year fellow at the Mays Cancer Center at UT Health San Antonio, the academic health center of The University of Texas at San Antonio (UT San Antonio), recently earned the prestigious Healio NextGen Disruptor Award at the American Society of Clinical Oncology (ASCO) 2026 annual meeting in Chicago.
First-of-its-kind discovery earns UT Health San Antonio Mays Cancer Center fellow prestigious Helio NextGen Disruptor Award
Colton Frisco Jones, MD, a 2nd-year fellow at the Mays Cancer Center at UT Health San Antonio, the academic health center of The University of Texas at San Antonio (UT San Antonio), recently earned the prestigious Healio NextGen Disruptor Award at the American Society of Clinical Oncology (ASCO) 2026 annual meeting in Chicago.
How Elifin is reshaping the commercial real estate playbook
Elifin is leveraging a decade's worth of proprietary commercial real estate data as well as artificial intelligence to reshape how properties are marketed, analyzed and sold. The Baton Rouge-based … Already an INSIDER? Sign in. Already an INSIDER? Sign in
Supreme Court sides with big business in Roundup cancer risk fight
The ruling is also a victory for the Trump administration and a defeat for the Make America Healthy Again movement.
Psychedelic Science 2027 Speaker Submission Invites the Field to Bridge Promise and Practice
Psychedelic Science 2027 (PS27) convenes May 3–7, 2027, at the Colorado Convention Center in Denver under the theme “Bridging Promise & Practice”PS27’s speaker submission is now open through Friday, September 18, with no planned extensionsPS27 welcomes proposals across science, therapy, policy, culture, industry, the humanities, spirituality, connected movements, and the wisdom traditions that have carried this work for generations DENVER, June 25, 2026 (GLOBE NEWSWIRE) -- The Multidisciplinary
FDA's breakthrough pipeline fills up with generative AI devices
In this edition of STAT Health Tech: FDA drops enforcement against Whoop, more AI devices get FDA 'breakthrough' label, and more.
'This is the next jump in technology': World's first sub-1nm chip keeps Moore's Law alive a little longer
IBM's NanoStack architecture has helped scientists cram 100 billion transistors onto a computer chip, delivering 50% better performance and consuming 70% less energy than the current generation.
David P. O'Brien
About five years ago, David P. O'Brien had a comfortable position at Marsh & McLennan Cos., where he held the top post at the financial giant's Louisville, Ky., office. Despite the lofty rank, Mr. O'Brien found himself longing to be at a smaller company that had to work a little harder to land business. That desire led him away from Kentucky five years ago and to Cleveland, where he serves as executive vice president at business insurance agency Oswald Cos. "I left Marsh before it was en vogue," he said, referring to layoffs and defections at Marsh over the course of this year that followed accusations of bid rigging at the big firm. Above all, Mr. O'Brien, 38, wanted to work at a company that relied on its inventiveness, rather than its name, for business. He said he has found that at Oswald. "It causes you to be more creative, to be more resourceful," Mr. O'Brien said. For instance, an Oswald client seeking to do business internationally might be directed to the network of offices abroad run by competitors such as Marsh and Aon Risk Services Inc. "We're going to use whatever access into the market that makes the most sense for our clients," he said. Of course, using such a strategy can be dangerous for Oswald if its client decides to further a business relationship with one of the firms Oswald recommended. "That's the obvious question and why it's nontraditional," he said. "I think if we're good, and if we're bringing value to the client, then there's no risk. I'm not threatened by it." Imaginative business solutions of that type made his career move to Oswald from Marsh worthwhile. "It's very much a challenge," he said. "It helps you keep your edge. I'm all for the competition." John Jacunski, currently vice president and corporate controller at York, Pa., paper company PH Gladfelter Co., met Mr. O'Brien four years ago when Mr. Jacunski was at WCI Steel Inc. in Warren. So impressed was he with Mr. O'Brien's work for WCI that Mr. Jacunski has retained the Oswald executive at PH Gladfelter. "He's a young guy for the position he has, but he's done a great job for us," Mr. Jacunski said. Among his roles at Oswald, Mr. O'Brien leads the firm's client retention efforts and also serves as director of its property and casualty group. "You don't have the same human resources," he said of the job jump to Oswald. "You don't have, obviously, the safety net a big company has." But sometimes, it can be difficult to ascertain individual contributions when working at a big company. "I wanted to be able to see the end results of my work and my efforts," Mr. O'Brien said.
J.D. Vance is heir to a more radical politics than Trumpism
…if, of course, he believes what he’s saying
Lionel Richie cuts concert short over health issue after sitting down mid-performance
"What I have learned about my years of being in the business. When you are feeling dizzy, sit your ass down," Richie told the crowd.
🇺🇸 Y! Sports AM: Why not U.S.?
The USMNT, who play their final group stage match tonight, have given fans reason to believe in their status as contenders.
Lionel Richie falls sick, abruptly ends All Night Long tour opener
Lionel Richie abruptly cut his Minnesota concert tour opener short after "feeling dizzy" on stage.
AI for Small Business: The Quick-Win Approach
Voice of Business Blog Guest post from Greater Rochester Chamber member IT Insights of Rochester In 2025, 58% of small businesses report using generative AI tools, up from 40% in 2024 and 23% in 2023, according to the U.S. Chamber of Commerce. Adoption has grown quickly in just a few years and is now delivering…
Americans are struggling to pay for health care. Here's why.
Fewer than half of U.S. adults said they believed they could pay for health care, medical appointments and prescriptions,
Regenerative Agriculture and Population Health
Regenerative agriculture can enhance food quality and reduce harmful exposures through improved soil biology, biodiversity, and ecosystem health, yielding downstream benefits for agriculture, food systems, and human health. It may improve profitability through greater land resilience and lower input costs and may deliver benefits to farms, farmers, communities, and the broader environment. More research is warranted to understand the full range of potential health benefits of regenerative agriculture.
Samsung Galaxy A27 5G Brings an Immersive Display and Awesome Intelligence to More Users
Newest addition to the Galaxy A series features an Infinity-O display, combining a seamless viewing experience with reliable performance and intelligent tools for more users
LMC: Blue Star Shopping Center sees 40 percent surge in visits as redevelopment draws new restaurants, entertainment
Patrons are flocking to the new-look Blue Star Shopping Center in Watchung, fueling a surge in foot traffic that’s poised to continue with a growing slate of dining and experiential tenants.
Hims' obesity drug business may get boost as employers drop coverage
Telehealth provider Hims and Hers Health may get a boost next year from employers dropping coverage of weight-loss drugs like Novo Nordisk's Wegovy and Eli Lilly's Zepbound and Foundayo to rein in costs, investors and analysts say.
Elizabeth Warren says ‘frenzy’ of mergers under Trump could be reversed
Senator warns of ‘tsunami of anger’ against big companies and suggests future administrations may undo key deals
What's new to streaming this week? (June 26, 2026)
What’s new on Netflix, Prime Video, Hulu, and more? We've got you covered.
Best Prime Day laptop deals: Save up to $970 on MacBooks, Windows PCs
Laptops are very expensive these days. These discounts help.
Latest World & National News & Headlines
USA TODAY delivers current national and local news, sports, entertainment, finance, technology, and more through award-winning journalism, photos, and videos.
Prosus Investment Values Health Insurer Alan at $6.3 Billion
Prosus—the largest shareholder in Tencent Holdings and owner of food-delivery company Just Eat Takeaway—is investing €400 million in Alan.
Prime Day is here: We found 100+ deals from Apple, Lego, Sony, and more
Kindle e-readers, Apple Watches, and portable power stations are all highlights as we wrap day two of the Amazon sale.
New polls show Americans’ complicated feelings about the country, 250 years on
More than three-quarters of Americans think the country’s founders would be disappointed with the US today, according to a Gallup poll released this week – one of several new surveys spotlighting the public’s complicated feelings about the nation’s legacy as it approaches its 250th anniversary.
Stubborn, arrogant, a genius: France’s De Gaulle epic shows up the tepidity of our politics
The man who led Free France during Nazi occupation was single-minded to the point of obstinacy. But he believed in his own power to make history, says Guardian Europe writer Alexander Hurst
'GTA VI' preorders open for PS5 and Xbox: Price, bonuses, Ultimate Edition exclusives
All preorders come with a bonus Vintage Vice City Pack.
Sen. Elizabeth Warren: ‘Thank you Donald Trump’ for the issue that will decide the midterms
Felix Okpara selected by Orlando in NBA draft
Former Vol Felix Okpara selected by the Magic in the NBA draft.