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DHS buys three detention centers in California for $950 million
The GEO Group, a Florida-based private prison corporation, announced Monday that it had sold the detention facilities, including the Adelanto ICE Processing Center, totaling 2,644 Beds.
Karoline Leavitt joining Fox News as on-air contributor
Former White House press secretary Karoline Leavitt will become an on-air Fox News contributor next month, weeks after stepping down from her prior role to spend more time focusing on her family.
Former Trump press secretary Karoline Leavitt joins Fox News
Leavitt joins a long line of former White House secretaries who have made the jump to TV news punditry.
Florida's Jadan Baugh Has Another Tough Challenge Against South Carolina
After Missouri stifled the Heisman frontrunner, the Gators must revive their ground game against a relentless Gamecocks front to avoid a devastating mid-season collapse in Columbia.
Florida takes a plunge in USA TODAY Sports' Week 5 re-rank
Florida football's Week 5 road loss to the Missouri Tigers sent the Gators tumbling down USA TODAY Sports' re-rank.
'Here & Now' Highlights: Charles Franklin, Jason Stein
A month before the 2026 election, the Marquette Law School Poll shows candidates for governor neck-and-neck — poll director Charles Franklin explained where voters stand and why. Enrollment caps for ...
Tomball Regional Health Foundation’s support for Lone Star College System approaches $2.5 million
Just two years after graduating from Lone Star College-Tomball with an associate degree in nursing, Petronila Arrey
Weaner Pig Breakeven at $22.46, Up $12.25 From Last Week
When you consider that today’s purchased weaner would be sold in March 2027 using April 2027 futures, the weaner breakeven was $22.46, up $12.25 for the week, and $0.57 below the average cash price for the week of $23.03.
Carlos Rodón has earned the Yankees’ Game 3 ball
New York has not announced its Game 3 starter. Aaron Boone has said Carlos Rodón lines up for Game 3 […]
Offensive Line Looks Offensive: Spartans Rank Last in Sacks Allowed
From personnel shifts to coaching failures, a crumbling front wall has left the Spartans reeling as record-breaking sack numbers threaten to derail the Pat Fitzgerald era.
Former press secretary Karoline Leavitt lands her next gig: Fox News contributor
Former White House press secretary Karoline Leavitt is joining Fox News as an on-air contributor starting Nov. 1.
Former press secretary Karoline Leavitt lands her next gig: Fox News contributor
Former White House press secretary Karoline Leavitt is joining Fox News as an on-air contributor starting November 1 | WWJ Newsradio 950
Davids Fights Washington Healthcare Cuts with Plan to Lower Costs, Protect Kansas Hospitals
WASHINGTON, D.C. — Today, U.S. Representative Sharice Davids (KS-03) introduced a comprehensive package of healthcare legislation that directly counters Washington’s recent healthcare rollbacks, which are increasing monthly costs and closing rural hospitals. Davids’ efforts would protect Kansas families from rising medical costs, block new federal red tape, and keep local hospitals and health clinics open.
Livelong Women’s Health Summit Builds Momentum for 2027 Expansion
The Livelong Women's Health Summit brought together consumers, clinicians, researchers, and health experts for conversations spanning menopause, strength and performance, brain health, nutrition, hormones, and the science of aging. The Health & Fitness Association (HFA) served as a sponsor for the event.
Paid influencers and political ads - Illinois Times, the capital city's source of news, politics, arts, entertainment, culture
My associate Isabel Miller and I worked on a story last week about paid influencers in campaigns. We decided to look into it after reading news reports about how the Chicago Teachers Union has been using paid influencers in its battle to control the elected Chicago school board and Chicago Mayor Brandon Johnson is also […]
Collective Ethics in an Autocratic Climate: M. Gessen Discusses the “Politics of the Past and Politics of the Future”
What are our ethical obligations as students living, learning, and creating a politics of the future at Haverford College? We must establish a clear set of ethical principles that we are unwilling …
Science Corp. Announces Long-Term (36 Months) Results of PRIMA BCI Clinical Trial Showing Durable Vision Restoration in Blind Patients Suffering from Geographic Atrophy
Science Corporation, the neural engineering and brain-computer interface (BCI) company, today announced long-term (36 months) followup data from its pivotal ...
Ceiling collapse causes neighboring business to close in Northern Colorado
Former House Speaker Dennis Hastert dies at age 84
The Kendall County, Illinois, coroner said Monday that Hastert died of natural causes over the weekend
Lilly's Jaypirca approved as first-line CLL therapy
Eli Lilly’s Jaypirca has won FDA approval for previously untreated chronic lymphocytic leukemia and small lymphocytic lymphoma.
Apple event is reportedly happening next week, per Mark Gurman
Apple is expected to launch three new products next week on October 13, and per Mark Gurman, the product unveilings will happen at “an event.”
Supreme Court declines First Amendment case of students forced to remove ‘Let’s Go Brandon’ sweatshirts
The Supreme Court on Monday declined to take up a First Amendment appeal from two middle school students who were ordered to remove sweatshirts emblazoned with the words “Let’s Go Brandon,” steering clear of a case that could have clarified the power schools have to police potentially offense speech in the classroom.
Should Aging Be Called a Disease? Scientists Are Rethinking What It Means to Grow Older
What if the next big target in medicine is getting older itself? Researchers are taking that possibility seriously, with new tools, new clinics, and growing FDA attention. Instead of waiting for diabe...
Lions’ Jahmyr Gibbs Decision Makes Absolutely No Sense
Jahmyr Gibbs received just 15 carries against the NFL’s worst run defense as the Detroit Lions fell 32-26 to the Carolina Panthers.
Sony introduces AI upscaling to base PS5; Marvel's Wolverine and Ghost of Yōtei are first games to implement new tech
PlayStation Spectral Super Resolution (PSSR) remains exclusive to the PS5 Pro, which SIE says is the "gold standard"
‘Interstellar,’ ‘Nope’ headline Great Lakes Science Center’s DOME Movies After Dark fall lineup
The series also includes "V for Vendetta." Films are presented in the science center's DOME theater, with a six-story-high screen and an 11,600-watt digital sound system.
Windows malware uses Grok AI to help stay hidden, researchers say
x47.c Windows malware uses xAI's Grok to maintain persistence on infected PCs while stealing passwords, browser cookies and API keys from victims.
Top crypto group to pour millions into bipartisan slate of House races after key legislation stalls
WASHINGTON (AP) — A top cryptocurrency campaign organization is unveiling a bipartisan list of House members that it will support in the November midterms, as o
2026 Outstanding Women in Business
The 18th annual Outstanding Women in Business awards recognize a dozen well-accomplished professionals from across the region and in many industries who go above and beyond. The committee selected the winners from more than 80 nominations, all of whom were worthy. The criteria evaluated each nominee’s professional achievements, community impact, ability to break the glass ceiling and mentorship of other professionals, particularly women. In addition to profiling these women in the following pages, the Worcester Business Journal will celebrate this year’s Outstanding Women in Business at a special luncheon on Oct. 28 at the College of the Holy Cross. To join the celebration of these exceptional women, visit WBJournal.com and register. – Mark Conti, editor This Year’s Judges Worcester Business Journal considered 54 Central Massachusetts professionals for the 2026 Outstanding Women in Business awards, based on 83 nominations. These nominees were independently evaluated by two volunteer judges, who scored each on their professional achievements, community contribution and mentorship of young professionals. Samantha P. McDonald is a partner at Bowditch. She is an experienced, client-focused real estate lawyer, concentrating on business and real estate property law. She has been recognized as a WBJ Power 100 in the Class of 2026 and a “Top Women of Law” in Massachusetts Lawyers Weekly. Dr. Kavita Babu is chief medical officer and vice president of medical affairs at Heywood Healthcare, where she provides strategic and clinical leadership to advance high-quality, patient-centered care across the organization. She is also a member of the WBJ Outstanding Women in Business Class of 2025.
Apple's Newest Macs Just Got Their Biggest Price Cuts Yet on Amazon
Prime Big Deal Days sales are already starting, and have now hit Apple's brand new Mac mini and Mac Studio computers. You can get up to $199 off these 2026 devices with Amazon's latest savings. Note: MacRumors is an affiliate partner with some of these vendors. When you click a link and make a purchase, we may receive a small payment, which helps us keep the site running.
Some mental health providers hoping to serve Lane County's Oregon Health Plan members say they’re facing barriers
Aspire is one of a few healthcare providers in Lane County that told KLCC they want to – but haven’t been able to – get a contract with Lane County's Medicaid insurer Trillium. That’s left Aspire without access to its target population, and other providers considering scaling back their services.
Community health fair provides one-stop shop for Arlington families
Arlington's third annual community health fair brought crowds to Carlin Springs Elementary School over the weekend. From flu shots and eye exams to bike giveaways and tips for healthier eating, the event hosted by the Kiwanis Club of Arlington and VHC Health offered a one-stop shop for families. "It's a lot of fun on a
Flathead City-County Health Department to hold annual flu clinic
The Flathead City-County Health Department will hold its annual flu clinic Wednesday, Oct. 7, at the Flathead County Fairgrounds Expo Building.The clinic will r
NFL looking into an official cursing at Cardinals tight end Trey McBride
Line judge Jeff Seeman was caught on camera cursing at McBride, which drew the ire of union leader JC Tretter
Apple Watch Prime Day Deals Arrive With New All-Time Low Prices for Series 12 and Ultra 4
Big Apple Watch discounts have started arriving ahead of Prime Big Deal Days, including new low prices on Apple Watch Series 12 and Apple Watch Ultra 4. These deals join some Apple Watch SE 3 discounts that we began tracking over the weekend, alongside other major early Prime Big Deal Days markdowns. Note: MacRumors is an affiliate partner with Amazon. When you click a link and make a purchase, we may receive a small payment, which helps us keep the site running.
Lumos offers family entertainment at Valley Ranch Town Center in New Caney
Greg and Brigette Little opened Lumos, a 45,000-square-foot entertainment venue with laser tag, bowling and Embers Grill, at Valley Ranch Town Center.
Orange County Celebrity Chefs and Health-conscious Founders This Month on ‘Walk-Ins Welcome’
We had an all-star line-up of guests in September on “Walk-Ins Welcome.” Amar Santana of “Top Chef” and executive chef/owner of Vaca and Broadway talked about
Eurozone business activity grows at fastest pace in 41 months in September
Private sector growth accelerates as demand improves, while input costs, selling prices rise at fastest rates since May | Anadolu
Bruno Guimaraes Details Heavy Brazil Workload Ahead of Arsenal Return
Bruno Guimaraes has revealed the amount of travelling Brazil faced during a demanding international window before his return to Arsenal.
Tracking health misinformation helps pediatricians provide targeted patient education
Pediatric clinicians can learn useful information by tracking the health misinformation that their patients encounter, according to research presented during the American Academy of Pediatrics 2026 National Conference & Exhibition Oct. 2-6, 2026, at the San Diego Convention Center.
Why more tools are making independent agents less productive
Having more technology than ever, independent agents are spending more time on administration, not less. The industry selling them those tools carries more responsibility for that than it typically admits
Detroit Lions vs. Arizona Cardinals Point Spread Revealed
The Detroit Lions are favored on the road against the Arizona Cardinals in Week 5. Check out the latest FanDuel point spread, moneyline and total.
Windber institute's data tracking system used by scientists far and wide
Developed by a member of the Chan Soon-Shiong Institute of Molecular Medicine at Windber, a system for using data to solve real-world problems caused by cancer is making a mark
Datavant, ID.me partner on digital identity verification for medical records
Datavant is partnering with identity verification company ID.me to help patients request their medical records faster and more easily via simple digital credentials. | Datavant has teamed up with ID.me to streamline medical records requests, enabling patients to verify their identities digitally and access records faster.
George L․ Kumar: Six Biology Breakthroughs Stockholm Missed
George L․ Kumar: Six Biology Breakthroughs Stockholm Missed / Ben Barres, cancer, Colin MacLeod, Ernest McCulloch, George L. Kumar, James Till, Kavli Prize,
Pope Francis' diaries to be published next month, revealing reflections on Vatican years
Pope Francis' journal entries from his time in the Vatican and years before will be published this fall | WBBM Newsradio 780 AM & 105.9 FM
Pope Francis' diaries to be published next month, revealing reflections on Vatican years
Pope Francis' journal entries from his time in the Vatican and years before will be published this fall | Talk 1370
Pope Francis' diaries to be published next month, revealing reflections on Vatican years
Pope Francis' journal entries from his time in the Vatican and years before will be published this fall.
NBA executive: 'There's definitely interest' in Bronny James
If the Lakers are willing to listen to offers, they could get back some value in a trade for Bronny James.
Back to The Ballroom: Yacht Rock Night
On Sept. 29, 2026, the “Dancing with the Stars” ballroom transformed into relaxing vibes and good times for yacht rock night. While there was smooth sailing, the 13 couples experienced some turmoil on the dance floor.
Delta Health Center Receives Funding
Delta Health Center, Inc. has received four awards totaling $4,660,331.59 through the Mississippi Rural Health Transformation Program, a state initiative funded by the Centers for Medicare & Medicaid Services. Governor Tate Reeves announced the four RHTP awards on September 14, as part of 167 awards totaling more than $104 million statewide. The awards announced will […]
Delta Health Center Receives Funding
Delta Health Center, Inc. has received four awards totaling $4,660,331.59 through the Mississippi Rural Health Transformation Program, a state initiative funded by the Centers for Medicare & Medicaid Services. Governor Tate Reeves announced the four RHTP awards on September 14, as part of 167 awards totaling more than $104 million statewide. The awards announced will […]
Research Shows These 10 Diets Are Linked to Healthier Aging
A new study found that many different diets can slow biological aging.
Caden Hunter pitched like a Top 100 prospect in 2026
Orioles prospect Caden Hunter pitched his way into MLB Pipeline’s Top 100 with a dominant 2026 season.
Poole College Broadens Access to Graduate Business Leadership Certificate
Graduate students from any discipline, as well as prospective learners from outside NC State, may now pursue the certificate.
KUNC's 2026 midterm election voter guide for Northern Colorado
Everything Northern Colorado voters need to know about the state’s midterm election, including major races, ballot measures, voting deadlines, how to return your ballot, and where to find trusted election resources.
London City gelling, Man City flying
After five frantic weeks, the Women's Super League takes a two-week break, offering the perfect chance to take stock of a thrilling start to the season.
The Economics of Delta Healthcare
How well is the system? Experts weigh in on status While agriculture rightfully gains most of the headlines when it comes to the Delta’s economy, the role of healthcare in the region cannot be underestimated. Many challenges face healthcare providers in the region and the state recently stepped in to assist. Nonetheless, healthcare leaders in […]
AkzoNobel is selling its Southeast Asia decorative paints business to Nippon Paint for $1.35 billion
The deal covers seven countries and is expected to generate about $1 billion in net cash proceeds after taxes and minority partners
Gallery of Unearthing the Ground: Architecture and the Politics of Waste - 1
Image 1 of 15 from gallery of Unearthing the Ground: Architecture and the Politics of Waste. Incineration Line in Roskilde / Erick van Egeraat. Image © Tim Van de Velde
Swedish regulator temporarily revokes Charm Entertainment AB’s casino licence following investigation
Spelinspektionen issued an interim revocation of Charm Entertainment AB’s licence to operate commercial land-based casino gaming.
Millions return to The Witcher 3 as the Remastered game records another Steam personal best and sales skyrocket
CD Projekt Red's overhaul of The Witcher 3 is pulling players back in their millions, while also attracting plenty of new ones.
Mac Users Reclaim Storage With New Apple Intelligence Removal Tool
A new open-source tool is making waves in the Mac community by helping users reclaim valuable storage space taken up by Apple's AI models. Called "RemoveMacAI," the tool disables Apple Intelligence on macOS 27, removes its downloaded models, and prevents them from being downloaded again. In macOS 27, Apple removed the toggle to disable Apple Intelligence wholesale, and simply disabling individual features doesn't remove the models from your Mac's drive.
Best Buy’s Techtober Sale Is Live with Big Discounts on PS5, Switch 2, and Xbox Games—and Unlike Prime Day, Deals Aren't Locked Behind a Membership
Best Buy's Techtober sale is now live, rivalling Amazon Prime Day with savings on new PS5 game releases, Xbox hardware bundles, and plenty more.
Nobel medicine prize goes to 3 scientists for research into brain activity
The Nobel Assembly praised their method, noting its global use in revealing brain mysteries.
Nobel medicine prize goes to 3 scientists for research into brain activity
The Nobel Assembly praised their method, noting its global use in revealing brain mysteries.
Obesity Startup Ilant Health Bets Its Revenue On Better Patient Outcomes
Founder Elina Onitskansky's Ilant Health has raised over $22 million to pair weight loss drugs with dietitians, behavioral health and peer support.
Hurricanes Beat Flyers 3-2 In Overtime With Gostisbehere Heroics
The Carolina Hurricanes survived a scare in Philadelphia, using a former Flyer's power-play goal to secure a 3-2 overtime win.
The Daily Mauling: 10/5/26
Kansas Jayhawks News It’s official, Melvin Council, Jr is coming back to Kansas Jalon Daniels got his first NFL start this weekend. It didn’t go especially well, but he vows to use the lessons he learned moving forward What did we learn from the 55-0 drubbing of MTSU? The LJW weighs in The Topeka Capitol-Journal […]
Ace Combat 8 is far and away the series' biggest launch on Steam
Despite releasing in a busy period, Ace Combat 8: Wings of Theve has already set new records for the flight action series.
THIS WEEK: “Sick of It! Fix Health Care Now” Bus Tour Kicks Off With Stops in Maine, New Hampshire, New York, Pennsylvania, New Jersey
Rep. Maggie Goodlander (D-NH-02), PA Lt. Gov. Austin Davis Will Headline “Sick of It! Fix Health Care Now” Events in Five States Watch All Bus Tour Stops Live Here. Washington,...
The science behind targeted oral peptides
A new type of medication is tackling a problem that has long frustrated drug developers: how to deliver peptide therapies orally and hit their target more precisely.
Integral Ad Science to Provide Brand Safety and Suitability Measurement in ChatGPT Ads
NEW YORK, October 05, 2026--As artificial intelligence rapidly reshapes digital advertising, marketers face a critical new challenge: ensuring brand safety and suitability within dynamic, generative AI-native environments. Without independent verification, advertising in conversational channels risks creating a blind spot for enterprise brands seeking reliable media quality standards.
Physician Assistant Brandon Guth Earns Reid Health’s Advanced Practice Provider of the Year Award
Brandon Guth, PA-C, a physician assistant with Reid Medical Associates, is the second recipient of Reid Health’s Advanced Practice Provider (APP) of the Year Award for his commitment to clinical …
The 2026 Lookout List: Health and Wellness
Are you feeling centered? This is a place where we value having aligned chakras, purposeful movement, a good gym to frequent and a good dispensary to drop into (for those that partake). For our Health and Wellness category of the Lookout List, we asked you for the best spots to drop into for yoga, mindful moments, health food and more.
Providence Opens New Rural Health Clinic in Polson
Just over a year after breaking ground on a rural health clinic in Polson, community members, donors and hospital staff gathered Sept. 30 in front of the new building just behind Providence St. Joseph Medical Center. “Over the years we’ve heard about this need over and over again,” Chief Executive for Providence Montana Krissy Petersen […]
Lions vs. Cardinals odds: Opening lines for Week 5 matchup
Checking in on the opening betting odds for the Week 5 matchup between the Detroit Lions and the Arizona Cardinals.
Jaguars vs. Eagles odds: Opening lines for Week 5 matchup
Sportsbooks project the Jaguars to beat the Eagles next week!
Walworth County dairy farmer specializing in raw milk says state is unfairly fining his business
Chaz Self said his dairy farm is producing grade A milk under Wisconsin's state standards, but was still ordered to pay a hefty fine. An online fundraiser has been created to cover those fines.
Business Roundup: Latham Aldi sets opening date, women-only gym expands into Slingerlands
Here's what's new in the Capital Region business scene.
Top Links 1245 Jobs in health care. Jobs for women. The US labour market is segmenting. Chernobyl’s radiation and Lenin’s love of literature.
Thank you for your support of Chartbook. Your generosity keeps this show on the road. Elmer Bischoff, Two Figures at the Seashore, 1957 The only really dynamic job-creator in the US economy is health care:
Jobs in health care. Jobs for women. The US labour market is segmenting. Chernobyl’s radiation and Lenin’s love of literature.
Thank you for opening your Chartbook email. Elmer Bischoff, Two Figures at the Seashore, 1957 The only really dynamic job-creator in the US economy is health care: The largest crunch has come in Federal government, which has shed 2.7 m jobs. Source: tchouvkov on Twitter Tech is struggling. [ Joey Politano 🏳️🌈@JosephPolitano The US tech sector continues bleeding jobs in official data released today—overall, employment decreased by 17k last month and is down 69k over the last year That's nearly as bad as the worst of the 2024 tech-cession, and much worse than the 2022 boom or even pre-2020 norms 12:42 PM · Oct 2, 2026 · 15.2K Views 15 Replies · 47 Reposts · 390 Likes ](https://x.com/JosephPolitano/status/2106001807847940232?s=20) The new jobs are all for women. [ Justin Wolfers@JustinWolfers I'm not sure who saw this coming, but so far nearly all the jobs created during the second Trump administration have gone to women. 1:09 PM · Oct 2, 2026 · 33K Views 70 Replies · 146 Reposts · 644 Likes ](https://x.com/JustinWolfers/status/2106008723533533601?s=20) Meanwhile, real wages are being eaten up by modest over-target inflation. [ Heather Long@byHeatherLong The financial pain is real: Wage growth fell to 3% (y/y) in September. That's the lowest in 5 years. Wage growth: 3% Inflation: ~3.4% Inflation has eaten up all wage gains for the average worker since April. Many people are having to make hard choices about what to buy and what … 1:24 PM · Oct 2, 2026 · 37K Views 24 Replies · 275 Reposts · 533 Likes ](https://x.com/byHeatherLong/status/2106012367712620728?s=20) HEY READERS, THANK YOU for opening the Chartbook email. I hope it brightens your day. I enjoy putting out the newsletter, but tbh, what keeps this flow going is the generosity of those readers who clicked the subscription button. If you are persuaded to click, please consider the annual subscription of $60. It is both better value for you and a much better deal for me, as it involves only one credit card charge. Why feed the payments companies if we don’t have to. Subscribe Elmer Bischoff, Bathers, 1960 Americans are disillusioned with higher ed. For contributing subscribers only. Subscribe Where the Chernobyl radiation went. h/t Simon Kuestenmacher aka simongerman600 How Lenin’s love of literature shaped the Russian Revolution - Tariq Ali This, then, was the intellectual atmosphere in which Lenin came of age. His father, a highly cultured conservative, was the chief inspector of schools in his region and much respected as an educationalist. At home, Shakespeare, Goethe and Pushkin, among others, were read aloud on Sunday afternoons. It was impossible for the Ulyanov family – “Lenin” was a pseudonym adopted to outwit the tsarist secret police – to escape high culture. At high school, Lenin fell in love with Latin. His headteacher had high hopes that he might become a philologist and Latin scholar. History willed otherwise, but Lenin’s passion for Latin, and taste for the classics, never left him. He read Virgil, Ovid, Horace and Juvenal in the original, as well as Roman senatorial orations. He devoured Goethe during his two decades in exile, reading and rereading Faust many times. Lenin put his knowledge of the classics to good use in the time leading up to the October revolution of 1917. In April of that year, he broke with Russian social-democratic orthodoxy and, in a set of radical theses, called for a socialist revolution in Russia. A number of his own close comrades denounced him. In a sharp riposte, Lenin quoted Mephistopheles from Goethe’s masterwork: “Theory, my friend, is grey, but green is the eternal tree of life.” Source: The Guardian Elmer Bischoff, The River, 1953 If you’ve scrolled this far, you know you want to click: Subscribe
Yale School of Medicine On the Science of Childhood Anxiety, Say, Anxiety Disorders Are the Most Common Mental Health Challenges In Youth
Credit: Matt Bradbury October 5, 2026 - By Isabella Backman - Anxiety disorders are the most common mental health challenges in youth. Left untreated, they can disrupt the lives of both children and their families. The good news is that with intervention, most children will overcome these conditions. Across Yale School of Medicine, scientists are working to understand anxiety at every level, from common anxious behaviors to molecular biomarkers in the brain. They are using their findings to develop and disseminate new evidence-based treatments for childhood anxiety. Today, the go-to treatment for childhood anxiety disorders is cognitive behavioral therapy (CBT). This is a form of psychotherapy that teaches children skills for confronting anxious thoughts and helps them practice managing situations that cause anxiety. While it is the gold-standard treatment backed by considerable scientific evidence, up to 50% of children will not see sufficient benefit from CBT alone. Wendy Silverman, PhD, Alfred A. Messer Professor in the Child Study Center, co-directs the Anxiety and Mood Disorders Program alongside Eli Lebowitz, PhD, associate professor in the Child Study Center. One of their main interests is learning how to improve outcomes beyond CBT. “We’re developing cutting-edge, research-based knowledge that can reduce the suffering that anxiety causes children and their families,” says Silverman. Changing parent behavior YSM experts are investigating how to improve CBT outcomes for children by involving the parents. Silverman’s research has uncovered two main components of parent intervention that improve childhood anxiety: not enabling children to completely avoid the things that make them anxious and taking steps to enhance their autonomy. Parents may unintentionally reinforce their child’s anxiety by allowing them to avoid what makes them anxious. They also may unintentionally limit the children’s sense of autonomy by being overly intrusive. “One of the things that we take pride in is that we’ve focused on trying to understand what parents need to do, and to test our ideas and see if changing the parents’ behaviors is enhancing the effects of CBT,” Silverman says. “Our findings thus far suggest that they do." As much as CBT can be helpful, it can also be challenging to get one’s child to do the necessary steps for CBT to work. This is one important reason why Lebowitz created a novel intervention program for parents named Supportive Parenting for Anxious Childhood Emotions (SPACE). Existing intervention programs often teach parents to act as therapists for their child, such as training them on how to practice breathing exercises. “It makes sense, but this doesn’t work very well in practice,” says Lebowitz. “And part of the reason, I think, is that it’s not easy to get your kid to do things, especially if they’re not excited about doing it.” SPACE is unique because it focuses entirely on parent involvement and changing parental behavior—children are not involved in the sessions. For example, parents learn how to use supportive messages that convey confidence that their child can tolerate and manage distress. “It might sound like a parent saying to a child, ‘I get that this is really hard for you, but I know that you can handle it,’” Lebowitz says. The program also works with parents to identify the ways in which they are accommodating anxious behaviors. “We’ll pick one thing that parents are doing that is an accommodation and help them make a detailed plan for how they’re going to change that,” Lebowitz explains. Treating Anxiety in Children and Adolescents Much of the existing research on SPACE has focused on parents of children under age 14. Ongoing studies are now exploring its use with parents of older teens. “Both anxiety and accommodation can interfere with normative developmental shifts during the teen years, including increased autonomy and individuation from parents,” says Rebecca Etkin, PhD, associate research scientist in the Child Study Center. “In this sense, SPACE may be particularly well-suited for anxious teens and their parents. We want to see whether it is effective during this distinct developmental window.” Unfortunately, many families in need of CBT face barriers, including limited availability of services and geographic constraints. One way to improve access is digital interventions. Silverman and her team are developing an evidence-based digitized intervention program for parents that they can access directly from their computer or smart phone. “The work we’re doing will be one of the very few parent interventions that is digitized and importantly tested for effectiveness,” she says. Creating interventions for anxiety-related challenges Silverman and Lebowitz recently received a generous gift to develop and test other interventions that help parents reduce other child anxiety-related behavioral and emotional difficulties, such as restrictive eating and unexplained somatic symptoms. One of these projects in particular focuses on understanding the risks of social media and its potential benefits, including offering a sense of connection. “A lot of research has focused on the idea that social media is harmful and the less of it the better,” says Lebowitz. “But we actually see is that this is not quite right—there are negatives, but there are also positives. So, we’re trying to get a little bit more nuanced of a picture.” The team is working with teens with social anxiety and their parents over an extended period to better understand their social media habits and how their anxiety levels affect engagement with different platforms. The teens will answer questions sent to an app on their phones about mood and social media usage in an effort to capture emotional responses as they unfold. “We hope to develop interventions that can help make the best of social media while protecting against the more problematic effects,” Lebowitz says. The brain’s role in anxiety Researchers are also testing therapies to address anxiety at the neurological and molecular levels. In collaboration with Dylan Gee, PhD, professor of psychology in Yale's Faculty of Arts and Sciences, and Hilary Blumberg, MD, John and Hope Furth Professor of Psychiatric Neuroscience at Yale School of Medicine, Lebowitz and Silverman are using brain imaging to identify changes in a child’s brain before and after parents enroll in SPACE. In one study, children viewed anxiety-inducing images while undergoing magnetic resonance imaging (MRI); the researchers conducted scans with and without the children’s parents nearby. Before SPACE, children’s brains were better able to activate the regulatory circuitry needed to turn off an anxious response when their parents were nearby. But after SPACE, children could activate this circuitry even without the parent around. “As parents work on gradually reducing some of their accommodations, you can see a child get better at regulating their own fear system in the brain,” Lebowitz says. “It’s remarkable.” Research into the molecular underpinnings of anxiety can also inform new childhood anxiety treatments. In a recent study, Lebowitz, Silverman, and Flora Vaccarino, MD, Harris Professor in the Child Study Center, discovered that a protein known as fibroblast growth factor 2 (FGF2) could be protective from the toxic effects of stress. FGF2 levels in children and their parents were linked to the children’s risk of developing anxiety and depression, the study showed. The findings could help explain why some children who are exposed to early life trauma such as poverty or abuse are more prone to developing mental health disorders. And FGF2 could be a target for treatment. “This is very novel because it starts to give a clue to what is the molecular chain that connects those lived experiences to the actual psychological outcomes,” Lebowitz says. New ways to study and treat childhood anxiety Michael Crowley, PhD, associate professor in the Child Study Center, collaborates with Silverman and Lebowitz to study the role that attention plays in development and maintenance of childhood anxiety. There is a large body of research that shows that anxious children, like anxious adults, are prone to focus on threatening stimuli such as angry faces compared with neutral faces. This has led to innovative interventions that involve attention retraining. The idea is that if experts train children to look away from threatening stimuli, it may reduce their anxiety—especially children with social anxiety who are most prone to attend to threats. The researchers have just completed a clinical trial for attention retraining with 10- to 14-year-olds with social anxiety disorders and are currently analyzing the findings. Besides this innovative attention retraining research, as Crowly notes, “I like to design tasks that are engaging to kids,” Crowley says. “My goal is to assess something without the kids knowing what we are assessing.” With this goal in mind, Crowley has created a virtual game, named Boom, to study threat processing in children with anxiety disorders. The game is similar to that of hot potato—the child and three digital players take turns virtually passing a ball to each other’s gloves. At some point, the ball turns into a bomb, and as the bomb lands in each player’s glove, the outline of the glove turns yellow. The goal is to avoid having the bomb go off in your glove. What isn’t obvious is that the game is designed to measure different types of threatening stimuli, both ambiguous and direct. In the game, the direct threat occurs as the bomb is traveling towards your glove. The ambiguous threat is the yellow outlined glove as it is unknown where the bomb will travel next. While children play the game, Crowley’s team measures their brain activity using electroencephalography (EEG). The researchers have discovered that in kids with anxiety, the brain reacts more strongly to ambiguous threats than it does in their peers, but less strongly to direct threats. They believe that the initial abnormally large brain response to not knowing where the bomb is going impairs the brain's ability to properly respond when the threat is actually traveling the child’s way. “The brains of children with anxiety are unable to differentiate between threats you need to do something about and those that are not your problem.” Michael Crowley, PhD, develops innovative games for studying anxiety in children and adolescents.Credit: Matt Bradbury Based on these insights, Crowley hopes to study whether interventions like attention training could restore appropriate threat processing. Crowley’s team is also working on a test called the Balloon Risk Avoidance Task, which evaluates risk-taking and avoidance behaviors. It features a digital balloon that is full of air and about to burst. Kids have six seconds to let air out of the balloon. The more air they let out, the less risk they face that the balloon will pop. But at the same time, the balloon becomes less valuable as it deflates. “The more air you keep in the balloon, the more points you get,” Crowley explains. So far, the researchers have found that when the balloons pop unexpectedly, teens with social anxiety show distinct brain responses. Studying these responses can help psychologists understand the underlying pathways driving the various manifestations of anxiety. The genetics of anxiety When Thomas Fernandez, MD, associate professor in the Child Study Center and of psychiatry, was still in training, there was a lot of excitement about understanding the genetics associated with autism spectrum disorder. Since then, scientists have identified around 250 genes associated with autism. The genetic contribution to anxiety disorders, on the other hand, has historically received less attention. Anxiety is less heritable than autism, but the genetic contribution for anxiety disorders that emerge in childhood may be higher than for anxiety disorders overall. While scientists estimate the heritability of anxiety disorders in general to be around 30% to 50%, some studies suggest higher heritability for certain childhood-onset anxiety presentations. “I saw firsthand how researchers in the field went about finding vulnerability genes for autism,” Fernandez says. “So, we’re using a very similar playbook for childhood anxiety.” “I saw firsthand how researchers in the field went about finding vulnerability genes for autism. So, we’re using a very similar playbook for childhood anxiety.” Thomas Fernandez, MD Associate Professor In the Child Study Center and in Psychiatry Now, Fernandez and Emily Olfson, MD, PhD, assistant professor in the Child Study Center, are studying children and their parents to identify genetic changes that are present in the child but not the parents, known as “de novo mutations.” “All of us have some de novo mutations—maybe about 50 to 100 sprinkled throughout the genome,” Olfson says. “But when they occur within the coding regions of genes, they can be really disruptive.” Previous research shows that people with autism have higher rates of damaging de novo mutations than the general population. In 2022, Olfson, Lebowitz, Silverman, and Fernandez published a study on 68 children and their families that found that children with anxiety had similarly high levels of these mutations. Studying de novo mutations can help point the researchers to where they should be looking for genes associated with anxiety. “The end game is using the genes to steer us toward the right part of biology that we can then target to come up with better treatments,” Fernandez says. Building on those findings, the team is now studying more families to better understand how these de novo mutations, along with other genetic and environmental factors, shape pediatric anxiety disorders. They recently received a National Institutes of Health grant to enroll 750 new families over the next five years. Olfson is the principal investigator, with co-investigators Lebowitz, Fernandez, Silverman, and Shuangge Steven Ma, PhD, department chair and professor of biostatistics at Yale School of Public Health. Neurodevelopment, Risk Genes, and Mental Health Conditions - The Olfson Lab Joel Gelernter, MD, Foundations Fund Professor of Psychiatry, is interested in how different anxiety disorders differ genomically. “We are studying social phobia, panic disorder, and generalized anxiety disorder, working to understand why people differ in their risk to these specific anxiety disorders and evaluating various risk factors,” he says. Gelernter was recently involved in one of the largest studies to date of the genomics underlying anxiety disorder. The study included around 122,000 people with anxiety disorders and around 730,000 without. It found that some genetic differences associated with anxiety were linked to signaling that helps reduce overactivity in the nervous system. Many anxiety medications available today work by targeting this process. “It’s nice when the biology that you get out of a large genome-wide study ratifies things that we already know because that can help increase confidence in further findings from the study,” Gelernter says. Uncovering the neurobiology of psychiatric disorders John Krystal, MD, Robert L. McNeil, Jr. Professor of Translational Research and chair of the Department of Psychiatry, is interested in the neurobiology of psychiatric disorders, including post-traumatic stress disorder (PTSD), of which anxiety is a major symptom. In the late 1980s, Krystal’s team discovered that the drug yohimbine activated symptoms in patients with PTSD. “This was the first time we could link a specific biological mechanism to the symptoms of PTSD,” Krystal says. At the time, he adds, this finding was highly controversial. “A lot of people felt that PTSD was a purely psychological syndrome that didn’t have an underlying biology.” Since then, Krystal has dived deep into understanding the neurobiology of PTSD to learn how to better treat it. His team is evaluating the use of ketamine and psychedelics. These would be among the first treatments to be developed specifically for PTSD. They may also be applicable for other disorders including anxiety disorders, Krystal adds. An important gap in PTSD treatment is the absence of biological tests that inform how to best help patients manage their PTSD symptoms. A doctor doesn’t diagnose cancer based on how they feel. Rather, they use tests of the biology of the cancer to determine the best course of treatment. “And we can’t do that in any psychiatric disorder other than Alzheimer’s disease,” Krystal says. “But now we are building a foundation for this approach to the treatment of anxiety disorders for the first time.” Source: Yale School of Medicine
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Novant Health hiring event kicks off in Greenville
FOX Carolina's Scottie Hunter has the details.
Novant Health hiring event kicks off in Greenville
FOX Carolina's Scottie Hunter has the details.
Novant Health hiring event kicks off in Greenville
FOX Carolina's Scottie Hunter has the details.
Novant Health hiring event kicks off in Greenville
FOX Carolina's Scottie Hunter has the details.
Novant Health hiring event kicks off in Greenville
FOX Carolina's Scottie Hunter has the details.
Novant Health hiring event kicks off in Greenville
FOX Carolina's Scottie Hunter has the details.
Novant Health hiring event kicks off in Greenville
FOX Carolina's Scottie Hunter has the details.
Novant Health hiring event kicks off in Greenville
FOX Carolina's Scottie Hunter has the details.
Novant Health hiring event kicks off in Greenville
FOX Carolina's Scottie Hunter has the details.
Novant Health hiring event kicks off in Greenville
FOX Carolina's Scottie Hunter has the details.
Novant Health hiring event kicks off in Greenville
FOX Carolina's Scottie Hunter has the details.
Novant Health hiring event kicks off in Greenville
FOX Carolina's Scottie Hunter has the details.
Novant Health hiring event kicks off in Greenville
FOX Carolina's Scottie Hunter has the details.
Novant Health hiring event kicks off in Greenville
FOX Carolina's Scottie Hunter has the details.
Novant Health hiring event kicks off in Greenville
FOX Carolina's Scottie Hunter has the details.
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