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Chambers’ donations outpace Millers 3:1 in battleground 41st District race

Brad Chambers, the Democratic challenger in the race for the 41st Pennsylvania House District, has raised three times more campaign funds than incumbent Brett Miller since June. Compared to Miller,

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Oct 26 • 4:51 PM EDT • Politics • lancasteronline.com
Keith Ellison sues businesses accused of stealing millions from child nutrition programs

The suit claims Nasib Bakery Food Distribution, LLC, and East African Health Network submitted millions of dollars in false claims to the Minnesota Department of Education.

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Oct 26 • 3:50 PM EDT • Business • startribune.com
CACI wins $281M Navy task order

Reston's CACI International has won a Navy contract worth up to $281 million to advance next-generation electromagnetic warfare capabilities.

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Oct 26 • 3:17 PM EDT • Business • virginiabusiness.com
CBS Sports reveals Florida's staggering $25 million-plus roster value

CBS Sports estimates Florida's 2026-27 basketball roster is worth more than $25 million, with Thomas Haugh among the nation's highest earners.

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Oct 26 • 3:15 PM EDT • Sports • sports.yahoo.com
Laika's 'Wildwood' cracks the box office with a mature animation

Laika’s PG-13 stop-motion film “Wildwood” opened third with an estimated $11.6 million. Here’s what its debut says about the market for mature animation.

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Oct 26 • 3:03 PM EDT • Entertainment • latimes.com
Election 2026 Daily: Govs. Hodges, Beasley endorse Annie Andrews. Kamala Harris for Jermaine Johnson

Former South Carolina governors Jim Hodges, a Democrat, and Republican David Beasley have endorsed Annie Andrews as millions in new outside spending flows to her and Darline Graham.

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Oct 26 • 3:00 PM EDT • Politics • postandcourier.com
Cherokee Federal company awarded contract to strengthen US Navy fleet readiness

Cherokee Nation Government Solutions, a Cherokee Federal company, has been awarded a $99.3 million, five-and-a-half-year contract through a competitive small business set-aside under the SeaPort-NxG contract vehicle.

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Oct 26 • 2:30 PM EDT • Business • cherokeephoenix.org
VIRAL VIDEO: League officials ask 3-year-old Florida soccer star, family to leave field, saying child ‘played too well’

A viral video with more than 4 million views posted over the weekend shows a 3-year-old soccer prodigy, Nevada, scoring goals against other children on his i9 Sports soccer team in Winter Park.

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Oct 26 • 2:28 PM EDT • Sports • news4jax.com
Lancaster Twp. nursing and rehab center sold for $10.7M

The Hamilton Arms Center nursing and rehabilitation center in Lancaster Township has been sold for $10.7 million to a partnership affiliated with its operating company.

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Oct 26 • 2:04 PM EDT • Business • lancasteronline.com
Wilmington Health facility sells for $9.4M

Wilmington Health’s main facility recently sold for more than $9 million. The 66,000-square-foot facility located at 1202 Medical Center Drive was purchased by Charlotte-based real estate investment firm Cedar Square in a $9.4 million sale-leaseback transaction, according to a deed recorded Oct. 21. Wilmington Health will continue leasing the facility, CEO Jeff James told the Business Journal in September. James said the lease term would likely be five years, with most services eventually transferring to a new medical office building under construction in the Midtown Park office area near The Pointe at Barclay. The Wilmington Health facility was originally listed earlier this year at $11.85 million. A Wilmington Health representative did not respond to a request for comment by press time. Steve Hall, vice president of BlueCoast Commercial, represented Wilmington Health in the transaction. “Wilmington Health wanted to unlock the value in its real estate without disrupting a single patient visit, and a sale-leaseback let them do exactly that,” said Hall in a text to the Business Journal Monday. “Cedar Square gets a long-term, absolute net investment anchored by one of the region’s leading physician groups, and Wilmington Health keeps its home on Medical Center Drive while redeploying that capital into care.” The sale marks Cedar Square’s first entry into the Wilmington market, according to Jon Dixon, the firm's managing partner and founder. “We are attracted to Wilmington's growth and what we see as strong long-term fundamentals,” said Dixon in an email Monday. “Population growth, relative affordability, and quality of life make it a compelling market for us. The climate and proximity to the coast are a big part of that appeal.” He added, “We hope to pursue additional opportunities across retail, industrial, medical office and multifamily in Wilmington. We will evaluate opportunities individually and remain disciplined about the properties we pursue. We would like this acquisition to be the beginning of a broader investment presence in Wilmington.” Given the facility’s age, Dixon said the site could eventually be redeveloped, potentially for medical office space or housing. Dixon said recent announcements from UNC Health and Atrium were among the factors behind the firm’s growing interest in Wilmington’s medical-office market. The announcements involve competing proposals for hospital expansion in New Hanover County, which are subject to the state’s Certificate of Need process. “Medical office remains one of the most sought-after asset classes in commercial real estate,” said Hall, “and well-located (medical office buildings) with strong operators are scarce in Southeastern North Carolina.” According to Dixon, Cedar Square describes itself as a boutique, hands-on real estate investment firm that values direct relationships with tenants and the communities where it owns property. “We’re very hands-on, and we like to be in direct contact with all of our tenants and the communities in which we own,” Dixon said. He added, “We’re definitely interested in building a presence with local owners, brokers and businesses or tenants.”

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Oct 26 • 1:58 PM EDT • Health • wilmingtonbiz.com
Langston University lands $2.25M NSF grant to boost STEM success over five years

LANGSTON, Okla. — Langston University School of Arts and Sciences announced it received a five-year, $2.25 million grant from the National Science Foundation to

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Oct 26 • 1:56 PM EDT • Science • fox23.com
Ishbia-backed Amtrak project gets deeper review amid Bridgeport backlash

Federal regulators are expanding their environmental review of a $900 million Amtrak facility in Bridgeport tied to Justin Ishbia's White Sox stadium plans.

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Oct 26 • 1:53 PM EDT • Business • chicagobusiness.com
Elvis has entered the courtroom

The owners of Elvis Presley’s music are suing Anthropic, alleging it helped itself to the King’s songs to train its AI — and sending a $41 million reminder, according to the New York Times.

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Oct 26 • 1:34 PM EDT • Business • businessinsurance.com
Recruiting expert picks Kentucky to land elite recruit Cherif Millogo

Cherif Millogo is now ranked as high as No. 8 overall in the 2027 class by ESPN.

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Oct 26 • 1:29 PM EDT • Sports • sports.yahoo.com
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American steel mills come with a health warning

Steel mills have had a major toll on the communities of Northwest Indiana, writes Mighty Earth’s Matthew Groch in Steel Times International.

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Oct 26 • 12:44 PM EDT • Health • mightyearth.org
David's Bridal Plans to Separate Its $350 Million Business. It Doesn’t Sell Wedding Dresses

The entity could soon become a publicly traded company. An expert says it represents a space that large retailers are continuing to invest in.

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Oct 26 • 12:15 PM EDT • Business • inc.com
Earth’s first fully-marine amphibian stalked the seafloor with a chunky, bony body

‘Gerrothorax maritimus’ lived about 237 million years ago, when parts of China were covered by an ocean.

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Oct 26 • 12:00 PM EDT • Science • popsci.com
UMHB announces $2 million challenge grant for science lab facility

BELTON, Texas (FOX 44) – The University of Mary Hardin-Baylor (UMHB) has announced that a generous donor who wants to remain anonymous has offered a $2 million challenge grant to support the …

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Oct 26 • 12:00 PM EDT • Science • fox44news.com
Following NASA Grant, TCU Researcher Explains Planetary Defense

Rhiannon Mayne, Oscar and Juanita Monnig Endowed Chair of Meteoritics and Planetary Science at Texas Christian University, was recently awarded a $3.6 million grant from NASA that will use West Texas’

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Oct 26 • 11:51 AM EDT • Science • tcu.edu
As Trump brags about U.S. oil and gas company profits, his stocks gained millions during Iran war

A report from congressional Democrats found the president purchased millions in oil and gas stocks during the war.

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Oct 26 • 9:30 AM EDT • Politics • cbsnews.com
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Fanatics teams up with OpenAI for new AI-powered shopping suggestion feature

Fanatics is using AI to help shoppers navigate more than 1.5 million items of sports merchandise, with a Shop the Look feature powered by OpenAI Codex.

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Oct 26 • 9:02 AM EDT • Sports • cnbc.com
OU receives more than $5M for maternal health research

OU’s College of Nursing secured more than $5 million in new NIH funding for four maternal health research projects over four years.

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Oct 26 • 9:00 AM EDT • Health • journalrecord.com
Suki Secures $90 Million | Confido Health Expands Agentic Operating Platform

Check out today's featured companies who have recently raised a round of funding, and be sure to check out the full list of past healthcare IT fundings.

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Oct 26 • 9:00 AM EDT • Health • healthcareittoday.com
In brief: Orlando Bloom, Elijah Wood joining 'The Gentlemen'

Netflix is rounding up more gentlemen. Tudum announced Orlando Bloom, Elijah Wood and Ed Speelers are joining stars Theo James and Kaya Scodelario for the third season of The Gentlemen, which is currently filming in the U.K. and Morocco. Also added to the series cast are Dexter Fletcher, Robert Carlyle and Bugzy Malone, who appeared in the 2019 film that inspired the Netflix series. Daniel Ings, who played the drug-addled older brother Lord Frederick “Freddy” Horniman to James’ criminal mastermind Eddie Horiman, told HATC magazine he will not return for the third season. Netflix has not confirmed this …The action-adventure series Fallout has inspired a new reality show. Prime Video has revealed Fallout Shelter: The Experiment, an unscripted competition inspired by the post-apocalyptic drama series and the video game universe. The show “invites everyday participants to test their aptitude for the apocalypse in Vault-Tec's state-of-the-art bomb-proof vault shelters," according to Prime Video. Contestants will “go head to head in a series of high-octane drills, psychological dilemmas and morally challenging behavior trials.” The winner walks away with a $1 million prize. Fallout Shelter: The Experiment will begin streaming in January 2027 … TNCMS.AdManager.render({region: 'fixed-big-ad-top-asset', slot: 1, fold: "above"}); Bravo renewed a slate of its reality shows ahead of Bravo’s Fan Fest on Saturday. New York-based In the City has been greenlit for season 2, while Next Gen NYC is coming back for a third season. For viewers seeking a little Southern charm, The Next Gen universe will be expanding with a spinoff based in Atlanta, and Southern Hospitality is moving forward with a fifth season. Premiere dates have not yet been announced … Copyright © 2026, ABC Audio. All rights reserved. Thank you for reading kmaland.comAt KMA, we attempt to be accurate in our reporting. If you see a typo or mistake in a story, please contact us by emailing kmaradio@kmaland.com.

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Oct 26 • 8:30 AM EDT • Entertainment • kmaland.com
Financial Woes Looms Over Washington's Revenue Sports

With Washington basketball's season set to tip off in just a few days, the second of the Huskies' two revenue sports finds itself in a very similar predicament to the football team. According to a recent report from CBS surveying the roster spending of college basketball programs across the nation, Danny Sprinkle's program ranked last in the Big Ten, spending approximately $5-7 million in NIL on its players.

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Oct 26 • 8:01 AM EDT • Sports • thenewstribune.com
Southern Utah is turning away millions in convention business. Washington County has a $30M idea to change that.

Washington County says it's turning away millions in convention business. Its solution? A $30 million expansion of the Dixie Center.

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Oct 26 • 8:00 AM EDT • Business • sltrib.com
Golden celebration: Riverview Health Foundation commemorates 50th anniversary

What began in 1976 as a community effort to raise funds for equipment and hospital needs has evolved into a foundation that is set to have raised more than $19 million for local healthcare by the end of this year. The Riverview Health Foundation commemorated its 50th anniversary during an Oct. 2

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Oct 26 • 7:00 AM EDT • Health • youarecurrent.com
Phillies news: Alec Bohm, Aidan Miller, Rays

Go Birds (I guess)…

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Oct 26 • 7:00 AM EDT • Sports • sports.yahoo.com
Potential buyer of Weiss and West Suburban hospitals has mixed track record

Insight Chicago owes tens of millions of dollars to the state, and its Bronzeville hospital has been cited for numerous safety issues.

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Oct 26 • 6:00 AM EDT • Health • chicagotribune.com
Ex-OpenAI Science Chief Kevin Weil Raises $215M for Drug AI

Former OpenAI science head Kevin Weil launches Warp Sciences with $215 million to use AI and robotics for a critical stage of drug development.

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Oct 26 • 6:00 AM EDT • Science • parametric-architecture.com
Trump’s D.C. hotel is gone. Mar-a-Lago is now a GOP campaign cash magnet.

Republican campaigns, party committees and PACs have spent nearly $3 million at Trump businesses since his return to office, a Post analysis finds.

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Oct 26 • 6:00 AM EDT • Politics • washingtonpost.com
Inside the Trump Administration's Dismantling of a Health Care Research Office

The Agency for Healthcare Research and Quality has few remaining grant officers and has redirected millions in taxpayer dollars without telling Congress.

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Oct 26 • 5:29 AM EDT • Health • notus.org
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Student-loan borrowers' key midterms issue: affording higher bills

Over 10 million student-loan borrowers are behind on payments. Some are hoping the midterms will prompt policy change to protect those in default.

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Oct 26 • 5:25 AM EDT • Business • businessinsider.com
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Republicans are spending millions and still may not win districts drawn to favor them

Republicans redrew Congressional district lines to try to tilt the midterms in their favor. But now they are facing expensive and competitive races they had hoped to outmaneuver.

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Oct 26 • 5:00 AM EDT • Politics • kgou.org
Republicans are spending millions and still may not win districts drawn to favor them

Republicans redrew Congressional district lines to try to tilt the midterms in their favor. But now they are facing expensive and competitive races they had hoped to outmaneuver.

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Oct 26 • 5:00 AM EDT • Politics • wuwm.com
Concordia University - 50 Years In

Concordia University Irvine marks 50 years: from 36 students in 1976 to 28,000+ alumni and $45 million in new, debt-free facilities. Explore the milestones.

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Oct 26 • 4:12 AM EDT • Business • ocbj.com
Inglewood Starts Transit Development

Last week, Inglewood city officials broke ground on their scaled-down $261 million Inglewood Transit Connector project aimed at improving mobility between

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Oct 26 • 3:01 AM EDT • Business • labusinessjournal.com
Goldwind Science & Technology: 9M26 profit reached RMB2.9 billion as WTG sales rose and backlog hit 57.0 GW

9M26 revenue was RMB52.0 billion and attributable net profit RMB2.9 billion. WTG sales rose 3.02% YoY, while total backlog reached 57.0 GW; operating cash flow was negative RMB30 million.Original document: Goldwind Science & Technology Co. Ltd. Class A [002202] Slides Release — Oct. 26 2026This is…

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Oct 26 • 2:26 AM EDT • Science • tradingview.com
Actuarial Science Club Meeting

We will be welcoming a guest speaker, Mackenzie Duckworth, who works at Milliman. Milliman is among the world's largest independent actuarial and consulting firms. It will be a wonderful opportunity

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Oct 26 • 1:07 AM EDT • Science • theshorthorn.com
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How to Manage Symptoms of Heart Failure

(Feature Impact) Americans are facing a growing health challenge, with 1 in 4 adults at risk of heart failure, according to the Heart Failure Society of America. Additionally, approximately 6.7 million U.S. adults who are 20 years old or older are currently living with heart failure, and that number is projected to reach 8.7 million by 2030. googletag.cmd.push(function() { googletag.display('JGFI_Article_300x250'); }); Managing heart failure is a significant expense to the U.S. healthcare system, costing the nation approximately $40 billion in 2020 and expected to increase to approximately $142 billion a year by 2050.If you (or a loved one) are living with the condition, consider these tips to help manage it.Adhere to the Treatment and Follow-Up PlanOngoing outpatient care is important when managing heart failure. Understand the treatment plan provided by your healthcare team, make diet and lifestyle changes, take medications as directed and keep recommended follow-up appointments.Pay attention to changes in symptoms and communicate with your healthcare provider if treatment does not seem to be working as expected. If their conditions are left unmanaged, patients can experience a range of heart-failure-related symptoms such as shortness of breath, fatigue, buildup of fluid and more.Understand Challenges with Diuretic TreatmentDiuretics help the body remove excess fluid and are commonly used to treat swelling, or edema, associated with heart failure. Your provider may try different diuretics, sometimes referred to as “water pills,” to manage your heart failure symptoms. However, intravenous (IV) diuretic therapy may be required for some patients if symptoms continue.Ask About Treatment Options Before IV Care Is NeededFor some adults, a healthcare provider may consider recommending an at-home, non-oral diuretic option prior to escalating to IV therapy.For example, ENBUMYST™ (bumetanide nasal spray) is a prescription diuretic used in adults to treat edema associated with congestive heart failure. It’s administered as a nasal spray for short-term use to manage excess fluid with the goal of transitioning to oral diuretic therapy when appropriate.Talk with your healthcare provider to learn more and visit enbumyst.com. Read the full Prescribing Information and Patient Information.Photo courtesy of Shutterstock googletag.cmd.push(function() { googletag.display('JGFI_Article2_300x250'); }); Important Safety InformationWhat is ENBUMYST?ENBUMYST is a prescription medicine used in adults to treat swelling caused by excess fluid in the body (edema) from congestive heart failure, liver disease, and kidney disease.What is the most important information I should know about ENBUMYST?ENBUMYST is a diuretic that helps your body remove fluid. Losing too much fluid can cause dehydration, low blood volume, and increase the risk of blood clots. Blood abnormalities may include decreased salts (electrolytes), and increased nitrogen, glucose and uric acid. The risk of these abnormalities is higher in elderly people, those using higher doses, or those who do not get enough electrolytes by mouth.You should not use ENBUMYST if you have severe electrolyte loss. Tell your healthcare provider if you experience unusual thirst; dizziness or lightheadedness; weakness or tiredness; fast heart rate; dry mouth or tongue; sudden pain; redness or swelling in your joints; pain, swelling, redness, or warmth in your leg; shortness of breath or fast breathing; high blood sugar; dark urine; pale, tight, cool or clammy skin; muscle cramps; confusion.Do not use ENBUMYST if you have low or no urine production or are allergic to bumetanide or to any of the ingredients in ENBUMYST.Before using ENBUMYST, tell your healthcare provider if you have low electrolytes, are on a low-salt diet, have diarrhea, diabetes, nasal problems such as a runny or stuffy nose or polyps, a history of nasal injury or surgery, are or plan to become pregnant, are or plan to breastfeed.Tell your healthcare provider about all the medicines you take, including prescriptions, over-the-counter medicines, vitamins, and herbal supplements.ENBUMYST may cause serious side effects, such as worsening kidney function and ringing in the ears or hearing loss.The most common side effects of ENBUMYST include dehydration, headache, muscle cramps, dizziness, low blood pressure, nausea, and abnormal brain functioning with certain liver problems.These are not all the possible side effects of ENBUMYST. Talk to your healthcare provider for more information.Call your healthcare provider for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.US-ENBU-2600110 googletag.cmd.push(function() { googletag.display('JGFI_Article3_300x250'); });

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Oct 26 • 1:00 AM EDT • Health • journalgazette.net
Lula is declared winner of Brazil's election as Bolsonaro rejects results

Flavio Bolsonaro is refusing to concede defeat to incumbent President Luiz Inácio Lula da Silva, who bested him by nearly 4.4 million votes, following a chaotic delay in poll closing

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Oct 25 • 10:27 PM EDT • Business • yakimaherald.com
Chinese scientists discover “D-rex,” a giant fungus with roots stretching back 65 million years

Scientists have discovered a giant new fungus in China that grows up to 20 inches tall and weighs nearly five pounds, making it the largest known of its kind. Dubbed “D-rex,” its evolutionary lineage appears to have emerged shortly after the dinosaurs went extinct, raising intriguing questions about how that ancient catastrophe may have shaped its evolution.

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Oct 25 • 8:00 PM EDT • Science • sciencedaily.com
Scientists discover Arctic sea ice loss could be far worse than predicted

Arctic winter sea ice could disappear much faster than scientists previously expected, according to new research using climate clues from 6,000 years ago. By comparing ancient ocean sediments with modern climate models, researchers found that future winter ice coverage may be roughly one million square kilometers smaller than earlier predictions suggested.

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Oct 25 • 8:00 PM EDT • Science • sciencedaily.com
Lawmakers propose $11M fix to restore school sports and activities funding

by Katie Klingsporn, WyoFile Wyoming’s new school funding model added more than $250 million in state education funding, including for widely supported

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Oct 25 • 5:45 PM EDT • Sports • capcity.news
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Rep. Carbajal Meets with Cottage Health’s Head Honchos in Santa Barbara as They Brace for ‘Big Beautiful Bill’ Impacts

Trump’s bill expected to leave close to 40,000 Central Coast residents without health coverage, another 37,000 with higher premiums, and a roughly $40 million initial impact on Cottage.

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Oct 25 • 3:30 PM EDT • Health • independent.com
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Science 4 Everyone: How does sod and tall fescue work?

Science teacher and Storm Team4 Meteorologist Ryan Miller explains how to use sod in your yard to prepare for cooler weather.

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Oct 25 • 3:27 PM EDT • Science • nbcwashington.com
Inside 26-year-old’s club for million-dollar Chattanooga business owners

At 2nd American Restaurant on Thursday night, around 85 entrepreneurs who have scaled their businesses to at least $1 million in annual revenue sat to a family-style meal of beef cheek roast, airline chicken and the restaurant's signature bowl of mashed potatoes.

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Oct 25 • 2:01 PM EDT • Business • timesfreepress.com
‘You Can See Everything’ surges with $19.5M at box office; ‘Clayface’ takes No. 1

DC Studios scored a modest, R-rated win with “Clayface,” landing a $24 million opening weekend, according to studio estimates Sunday.

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Oct 25 • 1:17 PM EDT • Entertainment • seattletimes.com
'You Can See Everything' surges with $19.5M at box office; 'Clayface' takes No. 1

DC Studios scored a modest, R-rated win with “Clayface,” landing a $24 million opening weekend, according to studio estimates Sunday | KCBS All News 106.9FM and 740AM

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Oct 25 • 1:16 PM EDT • Entertainment • audacy.com
'You Can See Everything' surges with $19.5M at box office; 'Clayface' takes No. 1

DC Studios scored a modest, R-rated win with “Clayface,” landing a $24 million opening weekend, according to studio estimates Sunday | KNSS Radio

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Oct 25 • 1:16 PM EDT • Entertainment • audacy.com
'You Can See Everything' surges with $19.5M at box office; 'Clayface' takes No. 1

DC Studios scored a modest, R-rated win with “Clayface,” landing a $24 million opening weekend, according to studio estimates Sunday.

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Oct 25 • 1:16 PM EDT • Entertainment • clickorlando.com
'You Can See Everything' surges with $19.5M at box office; 'Clayface' takes No. 1

DC Studios scored a modest, R-rated win with “Clayface,” landing a $24 million opening weekend, according to studio estimates Sunday | KMBZ

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Oct 25 • 1:16 PM EDT • Entertainment • audacy.com
'You Can See Everything' surges with $19.5M at box office; 'Clayface' takes No. 1

DC Studios scored a modest, R-rated win with “Clayface,” landing a $24 million opening weekend, according to studio estimates Sunday.

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Oct 25 • 1:16 PM EDT • Entertainment • news4jax.com
'You Can See Everything' surges with $19.5M at box office; 'Clayface' takes No. 1

DC Studios scored a modest, R-rated win with “Clayface,” landing a $24 million opening weekend, according to studio estimates Sunday. But the biggest success story in theaters remained A24’s...

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Oct 25 • 1:16 PM EDT • Entertainment • stamfordadvocate.com
'You Can See Everything' Surges With $19.5M at Box Office; 'Clayface' Takes No. 1

NEW YORK (AP) — DC Studios scored a modest, R-rated win with “Clayface,” landing a $24 million opening weekend, according to studio estimates Sunday. But the biggest success story in theaters remained A24’s Elizabeth Holmes documentary “You Can See Everything,” which pulled in $19.5 million in its ...

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Oct 25 • 1:16 PM EDT • Entertainment • usnews.com
This Switch 2 sequel accessory was a few millimeters away from being good

The right stick gets in the way.

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Oct 25 • 1:00 PM EDT • Technology • theverge.com
Cattle Science Gets a $19.5 Million Upgrade as West Texas A and M Plans High-Tech Research Complex

West Texas A&M is building a $19.5M cattle research complex featuring AI technology, veterinary research and commercial-scale feedlot studies.

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Oct 25 • 12:45 PM EDT • Science • myvetcandy.com
Selena Gomez's vaping admission highlights hidden health risks doctors say millions face daily

Selena Gomez called vaping "stupid" after it altered her voice, but doctors warn the health risks go beyond vocal cord damage for millions.

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Oct 25 • 11:48 AM EDT • Health • foxnews.com
How Braves should handle $42 million Jurickson Profar situation

This could be one solution for the Braves.

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Oct 25 • 11:36 AM EDT • Sports • sports.yahoo.com
ESMO: Roche touts ‘convincing’ phase 3 KRAS data after win over rivals

Roche has shed more light on its investigational KRAS G12C inhibitor's phase 3 victory over Amgen’s Lumakras and Bristol Myers Squibb’s Krazati. The open-label Krascendo 1 trial enrolled 338 people with previously treated KRAS G12C-mutated non-small cell lung cancer (NSCLC). Patients who had already received a KRAS G12C inhibitor or pan-KRAS/RAS inhibitor were excluded from the trial. Participants received either divarasib once daily, Lumakras once daily or Krazati twice daily. Roche announced back in July that divarasib had demonstrated statistically significant improvements in progression-free survival (PFS) and overall survival (OS), meeting the trial’s primary and key secondary endpoints. But the Swiss pharma had been holding back the detailed data until now. At the European Society for Medical Oncology (ESMO) Congress in Madrid, Roche revealed that median OS for the 167 patients who received divarasib was 17.7 months, compared to 12 months for the 171 patients who received Lumakras or Krazati. The benefit was similarly clear when it came to median PFS, which stood at 9.8 months versus 5.7 months, respectively. A total of 44% of patients receiving divarasib were alive without disease progression at one year, compared to 24% of the control group, according to Roche’s presentation. It was a similar story for the objective response rate, which came in at 58% for divarasib versus 32% for the control group, while median duration of response was 11.9 months versus 6.9 months. Stefan Frings, M.D., Ph.D., deputy chief medical officer at Roche Pharma, told Fierce that the data made for a “very comprehensive, strong package, which should be convincing to health authorities.” “It’s an important advance for patients with lung cancer,” Frings said in an interview at a Madrid hotel during the conference. “It's a second-line setting, and patients who receive divarasib benefit compared to the current first-generation KRAS G12C inhibitors by having far longer overall survival,” he continued. “They live longer. They have better progression-free survival, better response rates, and with a safety profile which is—if [anything]—even better,” he said. According to Roche, 4.8% of patients receiving divarasib discontinued treatment due to treatment-related adverse events, compared to 11.7% in the control group. Serious treatment-related adverse events were also less common with divarasib, at 7.8% versus 15.2%. Roche’s confidence in divarasib had been building even before this phase 3 success. The candidate had already shown better potency and selectivity than the incumbent KRAS G12C inhibitors Krazati and Lumakras in preclinical tests. After cross-trial comparisons suggested that the edge translated into better clinical outcomes, Roche axed a study comparing divarasib to the chemotherapy docetaxel and went toe-to-toe with Lumakras and Krazati. “We designed the drug on purpose with higher potency and better selectivity,” Frings explained. “So, based on preclinical models, we clearly knew it would be superior to the first generation.” “It’s honestly not so frequent that pharma companies go head-to-head,” he added. “But if you want to make a point, if you want to convince payers, prescribers and patients … then a head-to-head win is rather rewarding.” While Amgen and BMS reached the regulatory finish line first for KRAS G12C-mutated, locally advanced or metastatic NSCLC in 2021 and 2022, respectively, they have struggled to capitalize on their head start. Krazati brought in $55 million for BMS in the second quarter, while Lumakras delivered $111 million to Amgen. For its part, Roche is aiming for peak divarasib sales of 1 billion to 2 billion Swiss francs ($1.2 billion to $2.5 billion), according to Frings. The Big Pharma is currently recruiting patients into a phase 3 trial comparing divarasib plus Keytruda against Keytruda plus chemotherapy in previously untreated advanced or metastatic nonsquamous KRAS G12C-mutated NSCLC. Roche has previously suggested that sales in metastatic disease would account for most of the forecast. Frings was tight-lipped on the exact timeline for a regulatory filing but said the Swiss pharma is “certainly keen to get this to as many patients as possible around the world.” Roche has more RAS drugs coming up behind divarasib. The pharma has already launched phase 1 trials of a pan-RAS inhibitor called RG6505 and a KRAS G12D inhibitor dubbed RG6620 in solid tumors. Roche’s partner Chugai Pharmaceutical is also testing a pan-KRAS inhibitor called AUBE00. Roche has made a “deliberate effort” to test a range of RAS drugs, Frings said. “If you have many rare mutations and you are scrambling to find sufficient patients, a pan-RAS inhibitor makes a lot of sense,” he explained.

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Oct 25 • 11:30 AM EDT • Health • fiercebiotech.com
Xbox Asked for $800 Million After Netflix Offered $500 Million for Game Adaptation Rights

Netflix offered Xbox $500 million for seven years of exclusive film and TV rights, and Xbox countered with $800 million, Puck's newsletter…

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Oct 25 • 11:17 AM EDT • Entertainment • northeasttimes.com
Their friend died of cervical cancer in 2020. Now, they advocate for women’s health in N.S.

Following the death of their close friend from cervical cancer in 2020, two women in Nova Scotia were left wondering how things might have been different had she been diagnosed earlier. Six years later, they have raised over $4 million to improve technology and infrastructure for women's health.

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Oct 25 • 11:05 AM EDT • Health • cbc.ca
Instacart Stock What Health Benefits Deal And $5 Million Settlement Mean

Instacart parent Maplebear has agreed to a US$5,000,000 settlement with U.S. authorities over past PERM hiring practices and has been selected by True Rx Health Strategists to power an employer funded healthy food benefit through Instacart Health Fresh Funds starting in 2027. The True Rx program positions Instacart within pharmacy benefit design and ties employer spend directly to clinically supervised food choices. The settlement adds compliance obligations, policy changes and monitoring...

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Oct 25 • 10:08 AM EDT • Health • finance.yahoo.com
DOE expands tribal energy funding to $125M, selects 63 projects

The Department of Energy expanded a $50 million tribal energy funding opportunity to more than $125 million after tribal applications sought roughly 10 times the initial amount. The agency selected 63 tribe-led projects across 16 states for what it described as the largest single investment in the Office of Indian Energy’s history. The projects include […]

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Oct 25 • 9:00 AM EDT • Business • tribalbusinessnews.com
How LaLiga Turned a Global Soccer Brand Into an $87 Million U.S. Business

LaLiga’s successful expansion into North America shows how to turn a global sports brand into a sustainable business.

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Oct 25 • 9:00 AM EDT • Business • inc.com
McMillan backs Coombes after groin grab allegation

Munster head coach Clayton McMillan backs Gavin Coombes after the back row alleged he had been grabbed in the groin in Saturday's defeat by Leinster.

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Oct 25 • 8:36 AM EDT • Sports • sports.yahoo.com
NVIDIA's open-source path tracer gets 20% faster with RTXPT 1.9

NVIDIA's open-source path tracer now supports up to 2 million lights, SHaRC caching by default and Windows ARM64, alongside multiple rendering optimizations.

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Oct 25 • 8:17 AM EDT • Technology • videocardz.com
Three giant black holes discovered in a galaxy from the dawn of time

Astronomers have discovered three actively feeding black holes inside a single galaxy more than 12.5 billion light-years away, revealing a remarkable scene from the universe’s infancy. Two of the black holes are separated by just 620 light-years and are expected to eventually merge, while a third lurks farther away. One weighs an astonishing 80 million suns, and another is growing faster than conventional theories predict.

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Oct 25 • 8:00 AM EDT • Science • sciencedaily.com
Guest Commentary: How anti-Muslim politics endangers every Floridian

The political caricature of Muslims as a national security threat bears little resemblance to the reality that Floridians are living, working, and raising families in peace with nearly half a million Muslims woven into the fabric of the state.

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Oct 25 • 5:30 AM EDT • Politics • orlandosentinel.com
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‘Once we lose these, they’re gone forever’: What will become of the dioramas at the Academy of Natural Sciences?

The museum’s closure could endanger the 32 dioramas. Moving them can cost millions.

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Oct 25 • 5:01 AM EDT • Science • inquirer.com
The boss whose twice-bust business appears to be back despite £3m debts

Andrew Woosnam took millions from his companies before leaving creditors including HMRC out of pocket

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Oct 25 • 5:00 AM EDT • Business • theguardian.com
In Arkansas, Democrats see an opening at the edge of the competitive midterms map

In a sign of the potentially dire midterm political environment, Republicans have spent millions of dollars playing defense in Arkansas, one of the most conservative states in the country.

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Oct 25 • 5:00 AM EDT • Politics • npr.org
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Business briefs: Harry Reid airport completes $71 million baggage upgrade

In Terminal 1, the work included upgrades to eight baggage carousels, replacement of eight others, new conveyors and new carousel columns with LED screens. In Terminal 3, the project upgraded the computer hardware and software that control the baggage system …

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Oct 25 • 5:00 AM EDT • Business • lasvegassun.com
Browns sign Maliek Collins to $30 million extension

The Cleveland Browns have secured one of their standout defensive players for the future before their next game against the Tennessee Titans . Cleveland defensive tackle Maliek Collins has agreed to a two-year contract extension worth $30 million. According to NFL insider Ian Rapoport, Collins’ agent, Drew Rosenhaus, confirmed the agreement to him […] The post Browns sign Maliek Collins to $30 million extension appeared first on ClutchPoints.

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Oct 25 • 12:26 AM EDT • Sports • sports.yahoo.com
14-year-old entrepreneur’s slim business reaches millions online

A 14-year-old entrepreneur’s slime business has reached millions online and gained 21,000 followers in 23 days.

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Oct 24 • 8:35 PM EDT • Business • wndu.com
New evidence suggests spinosaurus spent most of its life underwater

Millions of years after animals first conquered land, some took an extraordinary evolutionary U-turn and returned to the water. Using machine learning and thousands of fossil measurements, Yale scientists have uncovered surprising clues about which prehistoric creatures truly became aquatic. Their findings suggest that Spinosaurus spent most of its life underwater, while some ancient marine reptiles previously thought to be fully aquatic actually spent considerable time on land.

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Oct 24 • 8:00 PM EDT • Science • sciencedaily.com
Cubs Have Easy Decision To Make About Jacob Webb

Coming off another dominant season as a reliable high-leverage arm, the veteran right-hander’s affordable $2.5 million club option makes retaining him a clear-cut choice for Chicago's bullpen.

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Oct 24 • 7:15 PM EDT • Sports • sports.yahoo.com
Is the WA ‘millionaires tax’ really coming for public pensions?

SEATTLE — When you think about the mansion- and yacht-owning millionaire crowd, retired schoolteachers don't typically leap to mind. Nevertheless, foes of Washington's new high-earner income tax are making a

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Oct 24 • 7:15 PM EDT • Entertainment • thederrick.com
The one thing Donna Mills refuses to do on her OnlyFans page

Donna Mills, 85, explains what she refuses to do on her OnlyFans page

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Oct 24 • 6:15 PM EDT • Entertainment • ew.com
Xbox Reportedly Bungled $500 Million Netflix Deal

According to industry insiders, newly appointed Xbox CEO Asha Sharma overplayed cross-media potential with recent Netflix exec Peter Rice to the tune of $800 million

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Oct 24 • 6:07 PM EDT • Technology • kotaku.com
Crushed between diamonds, ice changes shape, a clue to what lies inside Neptune

Physicists squeezed water to about 35 million PSI and saw its atoms rearrange into a less orderly pattern, a clue to Uranus and Neptune.

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Oct 24 • 5:06 PM EDT • Science • yahoo.com
Coyer Candle Co. nears $1 million raised for community groups

Coyer Candle Co., owned by Scott and Lisa Coyer, produces clean-burning candles with 100% soy wax and cotton wicks.

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Oct 24 • 4:08 PM EDT • Business • ourmidland.com
Oakland County business accused of making false statements to obtain federal loan agrees to $1M+ settlement

A Wixom, Michigan, business accused of making false statements to obtain a loan it was ineligible for has agreed to pay a settlement of just over $1.5 million after it was sued by the federal government, according to the Department of Justice.

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Oct 24 • 3:58 PM EDT • Business • cbsnews.com
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Marijuana legalization tied to rise in heart hospitalizations, study finds

A study of 50 million hospital records found heart-related admissions rose faster after recreational marijuana sales became legal in 13 Western states.

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Oct 24 • 3:34 PM EDT • Health • usatoday.com
Sportsbooks, Prediction Markets Set Records for Political Spending

Sportsbooks routed more than $80 million through a super PAC as the AGA and Kalshi stepped up lobbying in a fight over prediction markets.

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Oct 24 • 3:27 PM EDT • Politics • rg.org
South Bend teen’s slime business racks up 21,500 followers and 6.1M views in 23 days

A 14-year-old South Bend-area entrepreneur has gained more than 21,500 Facebook followers and 6.1 million video views in just 23 days with her slime and squishy

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Oct 24 • 3:02 PM EDT • Business • wsbt.com
As Florida governor’s race tightens, Ken Griffin gives another $5 million to Donalds

Ken Griffin said: “The people of Florida deserve leaders who wake up every day thinking about how to make their lives better.”

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Oct 24 • 2:11 PM EDT • Politics • miamiherald.com
Capcom Confirms Data Breach That Affected 11.7 Million Users

Capcom ID is still available to use, but users may see more phishing scam emails.

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Oct 24 • 12:40 PM EDT • Technology • engadget.com
Popular Sol de Janeiro perfume mists, ranked from worst to best

Gen Z loves $39 perfume mists from Sol de Janeiro the same way millennials loved scents from Victoria's Secret and Bath & Body Works.

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Oct 24 • 12:36 PM EDT • Business • businessinsider.com
Yankees Should Probably Avoid Massive $90 Million Risk

The New York Yankees probably shouldn't go down this road.

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Oct 24 • 12:22 PM EDT • Sports • sports.yahoo.com
CVS Health (CVS) Stock May Be Undervalued Despite Opioid Settlement

CVS Health has delivered solid gains over the past few years, and recent headlines have kept the company firmly in focus. With the stock around US$93, the question for you is whether that price is well supported by the earnings CVS generates today. Over the past 3 years CVS Health has returned 57.9%, which puts real weight on whether current earnings can shoulder the higher valuation investors are now paying. The US$315 million opioid settlement and related compliance upgrades may affect...

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Oct 24 • 9:07 AM EDT • Health • finance.yahoo.com
Fargo couple plans to relocate Stabo to former Swanson Health building

Matt and Lindsey Lee are buying the $1.5 million Hancock Building and adjoining Douglass Building in the heart of Fargo.

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Oct 24 • 8:00 AM EDT • Health • inforum.com
Gov. Newsom backs Lurie's reform measures

$13.5 million backs "Clean Up City Hall" propositions.

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Oct 24 • 7:00 AM EDT • Politics • sfexaminer.com
Billionaires pour millions into San Francisco politics and elections

Millions of dollars have poured into San Francisco elections this campaign season, funding a torrent of postcards, pamphlets and video ads inundating voters’ mailboxes and screens.

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Oct 24 • 7:00 AM EDT • Politics • sfchronicle.com
University of Scranton awarded nearly $5.5 million NASA grant for space science education

FOX56 WOLF TV carries news, sports, weather and coverage of local events in the Wilkes-Barre, Pennsylvania area, including Mountain Top, Plymouth, Nanticoke, Kingston, Back Mountain, Scranton, Moosic, Pittston, Avoca, Edwardsville, Hilldale, Wyoming, Laflin, Yatesville, Pittston, Dupont, Sugar Notch, Korn Krest, Warrior Run and Larksville.

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Oct 24 • 6:00 AM EDT • Science • fox56.com
Multimillion-dollar Pasco attractions business sends in the (creepy) clowns

Benjamin Nagengast turned his teenage paintball hobby into a family-owned attractions company that generates tens of millions of dollars a year.

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Oct 24 • 5:00 AM EDT • Business • businessobserverfl.com
Can millions of people live on the moon? These scientists say yes — but not for very long

Billionaires like Elon Musk and Jeff Bezos are claiming that we can expect big cities with millions of people on the moon, but a new study found that that may not be possible, so don’t start packing just yet.

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Oct 24 • 4:00 AM EDT • Science • cbc.ca
Washington Post

Elon Musk has cemented his record as the largest individual political donor in modern American history. Musk poured $446 million of his own money into this year’s midterm elections, mostly aimed at...

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Oct 24 • 3:32 AM EDT • Politics • facebook.com
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Titans $74 Million WR Tabbed Trade Candidate Before Week 7

A member of the Tennessee Titans wide receiver room is tabbed as a potential trade candidate by an NFL writer The post Titans $74 Million WR Tabbed Trade Candidate Before Week 7 appeared first on HEAVY.

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Oct 24 • 2:02 AM EDT • Sports • sports.yahoo.com
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Television Q&A: How are TV ratings tracked in the age of str...

Nielsen now combines viewer panels with data from millions of TV devices to track audiences across cable and streaming, while a TV Q&A also tackles wildlife-fil...

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Oct 24 • 12:00 AM EDT • Entertainment • unionleader.com