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After Aidan Hutchinson, who will lead the Lions in sacks?
Besides Aidan Hutchinson, who will bring the “juice” in the Lions pass rush in 2026?
Cottonwood Fire Chars Utah
The blaze burned more than 150 square miles and swept through parts of a ski resort.
National report: Oregon great for giving kids health insurance, bad for teaching them how to read
A new national report finds mixed outcomes for child well-being in Oregon and Washington.
Make the Business Case for Your Sustainability Initiative
Sustainability proposals often stall not because they lack merit, but because they are framed in a language that does not match how senior leaders allocate capital. While CSOs tend to emphasize impact, materiality, and disclosure, CFOs and CEOs need to understand cash flow, risk, and return. External reporting frameworks are useful for accountability, but they are poorly suited to internal investment decisions, which require project-level comparisons rather than aggregated enterprise metrics. Sustainability investments should therefore be evaluated like any other investment: by showing how they reduce current costs, avoid future costs, generate new revenue, or protect existing revenue. Strong cases begin with a clear business story that links the proposed action to a specific business impact and cash-flow outcome, then quantify what can credibly be quantified while treating harder-to-measure benefits as either upside or an explicit strategic bet.
Cornerstone Business Credit Funds $250K Line of Credit to Concrete Business
Cornerstone Business Credit funded a $250,000 line of credit to a company in the concrete business. With a building backlog of orders, customers paying in the
Integrating Behavioral Health Into Value-Based Care
Learn how a primary care–anchored model can improve behavioral health access, outcomes and value-based care performance
Kings F Nique Clifford Talks First Summer League Win
After burying a clutch go-ahead triple, the sophomore forward discusses his growth as a defensive anchor and his commitment to sparking a winning culture for Sacramento’s fans.
Kings Improve to 2-0, Late-Game Defense Stifles Warriors
Viktor Lahkin’s dominant interior presence and Emanuel Sharp’s clutch scoring erased a double-digit deficit, keeping Sacramento undefeated following a gritty defensive stand in the California Classic.
Colorado primary election voters shake things up
Every election has its surprises, but last Tuesday’s Colorado primary election results gave us several unexpected outcomes. U.S. Sen. Michael Bennett lost his bid to switch from the U.S. Senate and become Colorado’s next governor. Meanwhile, progressive Democratic U.S. Rep. Diana DeGette, from Denver, who had served 30 years in the U.S. House of Representatives, […]
Why Circulation Health Supplements Are Gaining Attention for Supporting Healthy Vascular Function and Everyday Wellness, According to PureHealth Research
PureHealth Research is highlighting growing consumer interest in circulation wellness and the role of targeted nutritional supplementation in maintaining healthy blood flow, vascular function, and overall cardiovascular wellness.Circulation health supplements commonly feature ingredients such as Omega-3 Fatty Acids, Berberine and Butcher's Broom, which are frequently included in formulations designed to promote healthy circulation and vascular health.
Dangers of youth using AI for mental health care
A nationwide study finds more and more teens are using A-I to replace mental health professionals. It’s led to some scary outcomes, even tragic endings. NBC 7’s Shandel Menezes sat down with some teens to hear what type of support they need.
Heart health and heat: How hot is too much?
As temperatures rise, so does the risk of dangerous outcomes
2027 Ferrari 12Cilindri Manuale Brings the Stick-Shift Back to Maranello—Kind Of
Ferrari's listened to the market and created a completely new shift- and clutch-by-wire system that promises to be just like the real deal, if not better. Genius or blasphemous?
Former NL MVP will continue his career, signs with Braves
The Atlanta Braves have made a veteran addition as they look to stay atop the National League playoff race, signing former National League MVP Andrew McCutchen to bolster their organizational outfield depth. McCutchen, who began the season with the Texas…
Mamdani’s politics of joy: What can Arkansas politicians learn from New York’s jubilant mayor?
Zohran Mamdani’s first half-year in office has been a mixed bag when it comes to policy outcomes. There is, however, one area of unquestioned success for the NY mayor: the forging of a sustained politics of joy unmatched by that of any major American politician in recent decades.
Klutch Sports CEO Rich Paul confirms Sixers have LeBron James' attention: 'Everything has changed'
On Friday morning's edition of his podcast, "Game Over," Klutch Sports CEO Rich Paul spoke glowingly about the Sixers as a potential fit for LeBron James.
12 Hilltoppers Named To Athlon Sports 2026 Preseason All-CUSA Team
BOWLING GREEN, Ky. – WKU Football had 12 players recognized on the Athlon Sports 2026 Preseason All-Conference USA Team.
After 18-year hiatus meant to attract new business and growth, Glades brings back impact fees
Fees pay for future infrastructure and services that growth will need.
Braves sign Andrew McCutchen to MiLB deal
It is a no-risk signing by Atlanta as they look to add options at the end of their roster.
Heat wave caused some 480 excess deaths in Netherlands, health authorities say
Last week's unprecedented heat wave led to around 480 excess deaths in the Netherlands, Dutch health authorities said on Thursday.
Heat Wave Caused Some 480 Excess Deaths in Netherlands, Health Authorities Say
AMSTERDAM, July 2 (Reuters) - Last week's unprecedented heat wave led to around 480 excess deaths in the Netherlands, Dutch health authorities said on Thursday. • Excess deaths in the week from June 22 to 28 were mainly among people aged 80 years and older. • Most were reported in the ...
Dutch Bros franchisee ousts MAGA in Shasta County
Shasta County has been ruled by a heavily conservative city council since 2020.
The Calif. Dutch Bros franchisee who ousted MAGA in Shasta County
Shasta County has been ruled by a heavily conservative city council since 2020.
Microsoft Frontier Company: AI engineering that amplifies and protects your intelligence
The pace of AI adoption is moving incredibly fast. Customers have moved well beyond experimentation and understand the importance of adopting AI to transform their business. They are now concentrating on delivering measurable business outcomes and demonstrating a return on their AI investments, while ensuring their intelligence is amplified and their IP is protected. Today...
Bonus 236: A Term of Self-Inflicted Wounds
Within minutes of the Supreme Court handing down the birthright citizenship ruling on Tuesday and rising for its summer recess, its defenders were pointing to that decision (alongside the late-arriving mail-in ballots ruling on Monday and the tariffs ruling from February) as decisive proof that the Court really is “above politics,” and that criticisms of the justices for behaving more like politicians in robes than like judges are thus unfair. For a particularly thoughtful version of this claim, see Professor Will Baude’s opening response to the latest New York Times written roundtable about the Court with Baude, Professor Kate Shaw, and me. In that roundtable, I already offered one of the two major arguments against this thesis—that it’s an assessment of the numerator without regard to the denominator, and that a full account of the Court’s behavior throughout OT2025 suggests that the Court behaved even more politically during the current term than during even the previous (highly politicized) one. Just to take one of many data points, last term (OT2024), there were six rulings in argued cases in which all six Republican-appointed justices were in the majority and all three of the Democratic appointees were in dissent (along with a slew of such rulings on the emergency docket). This term, there were … 13. (Along with two 6-3 summary reversals and 10 rulings on the emergency docket from which the three Democratic appointees all dissented.) Today’s bonus issue addresses the flip side of that coin. In particular, below the fold, I identify four different moments in which the justices could have acted in ways to specifically defuse charges of political behavior—and opted instead to lean all the way in. As much as end-of-term narratives focus on what the Court did, and on the takeaways from individual rulings, consider today’s post an attempt to identify opportunities that the Court missed, as well. At least in the examples discussed below, by opting for the outcome that made the Court look more transparently political, the Court inflicted a series of (unnecessary) credibility wounds on itself. For those who aren’t paid subscribers, we’ll be back Monday with our regular coverage of the Court. For those who are, please read on.
Applications Opened July 1 for Wyoming's Rural Health Transformation Funding
CHEYENNE, WY – Today, the Wyoming Department of Health (WDH) announced the opening of Requests for Applications (RFAs) for Wyoming’s Rural Health Transformation Program, a major initiative designed to strengthen healthcare access, improve health outcomes, and support innovative solutions for rural communities across the state. The funding opportunity represents an important step in implementing […]
British Business Bank bolsters board with four new directors
The British Business Bank has appointed four new non-executive directors across its boards, effective July 1, as chair Stephen Welton CBE is confirmed for a second three-year term
ACCESS Model: behavioral health edition
A new value-based care program for chronic condition management begins July 5. | A new payment model is designed to pay digital health companies based on outcomes in chronic condition management. But where does behavioral health fit? This episode explores that question with SonderMind and Headspace, two companies participating in the model's behavioral health track.
Yankees ‘Run It Back’ Offseason Plan Receives Interesting Take
Coming into the 2026 MLB season, there was some concern about the New York Yankees, as they decided to "run it back" over the offseason following a disappointing postseason outcome.
The Four Business Outcomes That Break When Enterprises Stop Validating Their Defenses - SPONSOR CONTENT FROM AWS AND TERRA SECURITY
Sponsor content from AWS and Terra Security.
Recent Research on How Experiencing Racial Discrimination Impacts Health
This brief provides an overview of the relationship between racial discrimination and health and highlights research examining mechanisms underlying health outcomes linked to experiences of racial discrimination, including biological changes, chronic stress, mental health, substance use, pregnancy-related outcomes, and sleep.
Milwaukee Brewers' Joey Ortiz Delivers Heroics in Late Innings
Facing roster pressure after a top prospect's arrival, the infielder silenced critics with a clutch eighth-inning blast to secure a vital victory and solidify his place with the Milwaukee Brewers.
Oil falls as investors focus on potential Iran-US talks in Doha
Oil prices dropped on Tuesday, with investors eyeing the outcome of potential U.S.-Iran talks in Doha amid weekend missile fire from both sides that tested an interim ceasefire to end the four-month-old war.
Netflix and Superheroes Are Having a Rough Stretch on Streaming....
(Welcome to my weekly streaming ratings report, the single best guide to what’s popular in streaming TV and what isn’t. I’m the Entertainment Strategy Guy, a former streaming executive who now analyzes business strategy in the entertainment industry. If you were forwarded this email, please subscribe to get these insights each week.) I have a quick prediction before we start today’s article: You might see this data in future news articles. Not my specific charts or analysis, but the core trend I’ve been monitoring—Netflix is having a lackluster Q2—will become inescapable. Often, folks want to know “What does the data say?” Well, that’s what it says. I haven’t seen this analysis hit the trades really yet, but I have a feeling some other outlets are going to start making this case soon. Remember, you read it here first. You probably have read about the problems facing superhero films at the box office this weekend. Well, this week, I explore whether superheroes are dying on TV as well! And the data says: definitely maybe! We have a lot to cover in today’s Streaming Ratings Report, which covers the two weeks of 18-May and 25-May. Today, I’m just looking at TV, like Netflix’s disappointing Q2, superhero shows underwhelming, a few TV shows dropping off the charts, The Pitt finally ending its epic run on the viewership charts (and whether “view counts” change its status as one of the biggest shows of all time), all the flops, bombs and misses, and a whole lot more. Tomorrow, I’ve got a great rundown of the film side of things. Let’s dive right in! (Reminder: The streaming ratings report focuses on the U.S. market and compiles data from Nielsen’s weekly top ten viewership ranks, Luminate’s Top Ten Data, Showlabs, TV Time trend data, Samba TV household viewership, company datecdotes, Netflix hours viewed data, Google Trends, and IMDb to determine the most popular content. While most data points are current, Nielsen’s data covers the weeks of May 18th to May 31st, 2026. You can find a link to my terminology here.) Subscribe Television - Netflix’s Q2 Slump Continues Having analyzed streaming ratings for going on half a decade, I have learned to trust my gut, but I’m always relieved when I can find actual data to back it up. For example, after a string of very popular shows like Stranger Things, Bridgerton, The Lincoln Lawyer and The Night Agent came out, week after week, in January and February, my gut wondered if Netflix had enough new and returning TV shows to sustain them throughout the year. Since then, Netflix’s post-March slate of shows has not impressed me. This week seemed to feature a potential new hit, but then, like a classic Duffer Bros. TV show, there was a twist. I speak of The Boroughs, Netflix’s latest (and last) Duffer Bros. produced show. The pitch is “Stranger Things with older actors”. And it topped the Nielsen charts: With just two weeks of viewership, The Boroughs would have been a top 25 debut show last year: But here’s the twist: Netflix has already cancelled The Boroughs! What happened? Likely a few things. First, the show didn’t do as well globally as it did in the US. As What’s on Netflix showed, it lagged behind several other shows that got cancelled. Second, its completion rate was likely low; after an initial burst of interest, it quickly dropped off on the Samba TV and Luminate charts. Third, the Duffer Bros. left Netflix for Paramount, and that may have factored into Netflix’s decision here. (Though I tend to believe that if a show is doing well, Netflix would have kept greenlighting seasons.) Still, just because I can explain why Netflix may have cancelled this show doesn’t mean I’m justifying it. In particular, as I’ve noted before, Netflix is losing a lot of their bigger shows as they reach their natural ends, and they need to replace those shows. This show had the hallmarks of a big new genre show, and it’s their biggest hit of the last few months (in the US at least), but now it’s done. Netflix’s other show this week—The Four Seasons, the second season of the “hit” show from last year—definitely disappointed. Its sophomore season had about half the viewership of the first, only 12.7 million hours. It also only had a two week run on Samba TV, and its numbers were all down on Luminate too. In other words, even with two successes, the Q2 slump for Netflix looks real: I could add to the list of disappointments: Both Lord of the Files and Man on Fire had short runs on the Nielsen charts. Running Point’s sophomore season also opened to about half its viewership, similar to The Four Seasons. A Good Girl’s Guide to Murder’s second season—see below—didn’t even make any of the three viewership charts I track, unlike the first season. Netflix is absolutely having a dismal second three months of 2026. If this Nielsen data is any indication, and I think it is, I think this will show up in Netflix’s engagement report, and maybe even their financial outcomes. And the rest of June doesn’t look much better. We have two hit shows coming back—Sweet Magnolias, one of their quietest big shows, and Avatar: The Last Airbender, a big hit for them in 2024—but the other big swings are limited series crime thrillers i.e. no future season potential. Like I said above, sometimes when I uncover a juicy nugget like this, other outlets end up writing very similar articles mimicking the data without credit. We’ll see if that happens this time! Share Television - The State of Superhero Shows on Streaming When I first heard the pitch for Spider-Noir—a Sony TV show on Prime Video that binge-released eight episodes first on MGM+ then on Prime Video two days later—I had my doubts. It’s a live-action Spider-Man show set in the 1930s, starring Nicholas Cage, based on a cameo of a character in Spider-Man: Into the Spider-Verse. No, seriously, that’s the pitch. That could either go terrifically well or horribly wrong. Great because, Spider-Man. He’s the biggest superhero we have. I’ve seen tracking numbers that put the new _Spider-Man: Brand New Da_y as the blockbuster of the year and initial pre-sales back that up. And yet this Spider-Noir pitch feels very esoteric. (Also, the eight-episode binge release feels very “Amazon copying Netflix” again.) So what’s the data say? And what does this say about the future of superhero shows?
What to Expect: Commercial Mission to Boost NASA’s Swift
A mission to boost the orbit of NASA’s Swift observatory is targeted to launch no earlier than Tuesday, June 30, at 10:17 p.m. UTC+12 (6:17 a.m. EDT).
Your money. Their mission. - Gary W. Rollins College of Business
Financial Literacy Ambassadors at the University of Tennessee at Chattanooga help their peers better understand finances through college.
Clients push consultants to adopt outcome-based fees to share in risk
Consulting giants like BCG and Accenture are shifting from fixed rates to outcome-based fees as clients push them to share the risk of AI integration.
A Doctor At Home: The Rise Of Ambient Home Health Monitoring
There is significant opportunity to improve long term health outcomes with ambient home monitoring.
Meaningful Outcomes Determine the Winners of the Health AI Race
Global investment in healthcare AI exceeded $18 billion in 2025, yet health systems still lack a shared understanding of the outcomes that investment should deliver. This paper argues that success in the health AI race will be determined not by technological sophistication but by which systems first identify and pursue the outcomes that matter most to patients, professionals and health systems. Without a shared language for defining and measuring what healthcare AI should deliver, systems risk optimizing for what is easiest to count rather than what matters most. This paper provides a framework for ensuring AI investment translates into real value for healthcare systems and the populations they serve.
Efzimfotase alfa demonstrated improvements in bone health in treatment-naïve pediatric patients with hypophosphatasia achieving median difference of 1.67 vs placebo in RGI-C Score at week 25 in MULBERRY Phase III trial
Positive results from the MULBERRY Phase III trial showed that efzimfotase alfa (ALXN1850), an investigational enzyme replacement therapy, demonstrated a statistically significant and clinically meaningful improvement in bone health in children (2 to
Design and Early Implementation Outcomes of a Mobile Health-Enabled Social Support Intervention for Adults Living With HIV and Type 2 Diabetes in Uganda
Background: Adults living with HIV and type 2 diabetes experience complex treatment demands that affect medication-taking, clinic attendance, privacy, social support, and engagement with care. M...
A lack of funding, a glut of stigma: How Ohio LGBTQ+ health outcomes are impacted
Being able to access healthcare in general is a struggle for LGBTQ+ individuals, and with legislation in Ohio and elsewhere that banned gender-affirming care for minors, for example, a need for healthcare can often clash with the hesitation to seek help.
Consumer-Directed Health Care: Promise or Pitfall
This panel will examine the evidence and policy outlook for consumer-directed health care as a federal solution to expanded coverage, with a focus on affordability, access, and health outcomes.
From Linchpin to Lever — Part 1: Measuring Trust in Public Health
Learn how local health departments can measure public trust using existing public health tools to strengthen relationships and improve community health outcomes.
ECU Health announces 2026 Board Quality Leadership Award winners
ECU Health Board Quality Leadership Award winners were recognized for delivering exceptional experiences and advancing patient outcomes.
The Big Summer Preview – A New Animation: The Butcher’s Nails
Witness a World Eater in the grip of the Butcher’s Nails.
Mental health as both outcome and determinant in climate adaptation
Nature Climate Change - Mental health should not be viewed solely as a passive outcome of climate adaptation. Rather, it serves as a key determinant of cognitive capacity and shapes the...
Making Our Own Luck
We are cross-posting a piece that former NIH official Kris Willis wrote for Macroscience. Kris is now the President and Founder of the Woodley Park Institute, for which I’m a board member. Picking winners or hedging bets? Federal science agencies have long wrestled with the question of how to ensure their billions of dollars of grants and contracts result in maximum benefits for Americans. On the surface, it might seem that a goal-oriented, interventionist style of management would be the best policy: prioritize our most pressing problems and distribute funding accordingly.This top-down strategy creates a unique hazard, though: bad choices can send resources in the wrong direction, resulting in slow progress that impedes the delivery of tangible benefits to citizens. Moreover, if decision makers pursue an applied advance when the underlying scientific principles remain poorly understood, they risk costly failures and a loss of support for the research enterprise at large. Examples include Nixon’s 1971 War on Cancer, undertaken on the premise that a cure could be achieved in less than a decade, the drive to build an operational commercial fusion plant by the mid-1990s, and the National Plan to Address Alzheimer’s Disease, which failed to produce the effective treatments and prevention strategies promised by 2025. The contrasting laissez-faire approach is to hedge your bets. If the path to an advance is impossible to predict, then the wisest choice might be to distribute funding to as widely as possible. The main risk of this strategy is that spreading funding thinly may limit the resources available to the most promising research, resulting in the same negative outcomes as the interventionist approach: limited support for the most promising topics, slow progress, and delayed returns. In reality, at science agencies like the National Science Foundation and National Institutes of Health, program managers navigate between these two extremes, setting some funds aside to target high-priority areas and using the rest to cover the widest possible range of meritorious proposals. This middle path seems like the most rational way to proceed, but it still requires making choices. How much should be set aside for high priority topics? What should those topics be? How should we define merit? Expert opinion can provide a helpful guide, but leading experts can have remarkably different opinions about what matters and what should be prioritized. Moreover, experts and administrators alike can be risk averse, giving an edge to high-profile, well-established concepts. What’s really needed is a data-driven framework to help guide decision-making, one that doesn’t simply repackage prestige or incumbency. Recognizing breakthroughs years in advance Many breakthroughs fail to attract funding or recognition at the earliest stages of development. Katalin Karikó, for example, spent years struggling to win grants for work on mRNA that would eventually win her and Drew Weissman a Nobel Prize. Similar stories can be told about Jim Allison’s groundbreaking studies leading to the development of cancer immunotherapy, Stan Pruisner’s demonstration that prions can self-replicate without DNA, or Robin Warren and Barry Marshall’s proof that Helicobacter pylori, not stress, causes ulcers. Yet at some point, the scientific community recognizes and responds to transformative breakthroughs like these. How does that change happen? And what if science funders could identify the areas that are on the cusp of a breakthrough? Those questions led my collaborators and me to study how scientists responded to past breakthroughs. Based on patterns in that data, we developed a means of predicting future breakthroughs, using biomedicine as a proof of concept. It’s worth taking a moment to describe how our approach works. Briefly, our prediction process begins by grouping the 18 million or so peer-reviewed papers in PubMed, the authoritative database of biomedical research, into roughly 50,000 unique topics. A small subset of these topics are so widely acclaimed as breakthroughs that they have been recognized with a major prize like a Nobel or a Lasker Award. We theorized that studying the development of these outliers over time, especially before they gained acclaim, was the key to identifying future instances of them. After defining topics, we chose 21 representative breakthroughs and asked what they looked like before they won prestigious prizes. To answer that question, we re-ran our topic-mapping algorithm repeatedly, winding back the clock one year each time, stringing together the years to follow the progress of each field as it grew and advanced. We found that in each case, the years leading up to a discovery followed a pattern: a burst of papers on a new, rapidly evolving topic, many of which quickly became influential. These characteristics—the percent of papers that are new, the percentage of papers that are brought in from other topics, and the influence of each individual paper—can all be measured separately for any given topic. Together, they act as a predictive signal that is detectable an average of five years before a transformative discovery is made, and up to thirty years before the discovery receives a major prize. Scanning the current research landscape for topics that display this signal allows us to predict what work will likely produce a future breakthrough. Each year we analyzed includes four or five signals, a number that appears to have remained constant across a twenty year time frame. In their classic work on the sociology of science, Bruno Latour and Steve Woolgar established that the desire to participate in a major discovery is an important motivator for scientists as they consider whether they should take up (or abandon) a research problem. Although further work is needed, the simplest explanation for our results is that this behavior is widespread enough to detect at scale. A foundational advance, or something like it, draws the attention of scientists and causes them to change the direction of their research. They vote with their feet, staking their own reputation and careers by publishing on and citing the new idea. That upswell of interest is the foundation of our breakthrough signal. What kind of research does our model identify as a breakthrough? After building a model based on the patterns in our 21 preselected breakthroughs, we tested it by identifying all early signals of discovery from 1994 through 1997. Of the 18 signals we found in that time period, 17 can be traced forward in time to a breakthrough. Examples include super-resolution fluorescence microscopy (see the image above), the directed evolution of proteins and enzymes (Chemistry Nobel, 2018), and sequencing the human genome (National Medal of Science, 2008). The discovery of the role of leptin signaling in obesity is a particularly interesting case study. Around 1950, scientists noticed the existence of a type of lab mouse that suffered from a unique inherited form of obesity. When given the freedom to choose their own diet, these mice ate more than normal and preferred food that was high in fat. Researchers had few clues as to why the animals overate; early experiments pointed to the existence of a soluble ob factor found circulating in the bloodstream that regulated appetite, but its identity was unknown. In 1994, Jeffrey Friedman and colleagues identified and sequenced the ob gene, noting that the protein it encoded appeared to fit the profile of a circulating factor. A year later, a trio of high-profile publications demonstrated that ob was a hormone that regulated body weight and fat deposition by regulating appetite. One of these was co-authored by Friedman, who christened it leptin from the ancient Greek word for thin. Using our model, the data from 1996 make it clear this advance would become a breakthrough. Scientists had flocked to study the biology of the new hormone, generating the flurry of new papers and citations required to produce a signal. One of these demonstrated that serum leptin concentrations reflected the amount of adipose tissue in the human body, providing clinical validation of the earlier mouse studies. Before the identification of leptin, scientists were unable to point to a specific molecule that controlled appetite and adiposity, so that it was impossible to rule out non-physiological causes of obesity; its characterization fundamentally changed our concept of weight gain. In 2010, Friedman and fellow pioneer Douglas Coleman were awarded a Lasker for the discovery. Our work also identifies breakthroughs in clinical practice and behavioral and social sciences, even though these areas are less likely to draw the attention of major prize committees. One example that falls into this category is the introduction of endovascular aneurysm repair, a minimally invasive surgical procedure for the treatment of abdominal aortic aneurysm, a leading cause of death among Americans over the age of 65. Relative to the previous standard of care, it reduces in-hospital mortality by almost four-fold. In 2017, Timothy Chuter received the American College of Surgeons’ prestigious Jacobsen Innovation award for his multiple refinements to the technique. Another under-recognized breakthrough identified by our model is the development of standardized survey instruments to assess the quality of life for HIV+ patients. The antiretroviral cocktails introduced in the mid-1990s reduced AIDS mortality, but treatment came with serious side effects. The new evaluations showed that patients whose disease progressed had worse physical functioning than Americans with other chronic diseases, while those who were asymptomatic maintained a health-related quality of life on par with the overall US population. This evidence made it possible for patients and activists to argue that even in the absence of a total cure, and in spite of the side effects, alleviation of symptoms was a worthwhile priority for clinicians. My colleagues and I have failed to identify any significant recognition for the physicians and health policy experts who pioneered this advance, although in 2016, researchers called for the World Health Organization to set targets for good health-related quality of life as part of its framework to end the AIDS pandemic. From forecasting to funding How should science funders use our predictions? Any serious discussion of what we should do with this new capability needs to begin with an understanding of its limitations. We can’t (and shouldn’t) invest all of our resources in the small number of topics predicted to produce breakthroughs. Innovative new fields are born from existing ones; they rarely arise de novo. If funders don’t maintain a diverse portfolio, the breakthroughs of tomorrow will have no antecedents. Think of this as eating the seed corn, or killing the goose that lays the golden egg. There are also multiple goals of funding beyond basic scientific discovery, including translating discoveries into clinical practice, developing new technologies, supporting economic development, and training new scientists. The investments needed to accomplish these goals are likely different from those required to support emerging breakthroughs. Finally, we must be aware that we may not capture every instance of a breakthrough. The concept is fuzzy, and not every significant discovery is recognized with a major award. Further, breakthroughs are rare, meaning that our dataset is, by necessity, small. This makes formal estimates of accuracy challenging. Although our overall success rate appears to be high, any one signal may turn out to be a false positive. We found one apparent example: the development of the third generation COX-2 inhibitors, Vioxx and Celebrex, which were much celebrated in the early 2000s as effective but non-addictive pain relievers, meets all the algorithmic criteria of a breakthrough. Five years after it received FDA approval, researchers demonstrated that Vioxx was associated with serious cardiovascular complications, and the manufacturer voluntarily pulled the drug from the market. Celebrex remains available, although like other NSAIDs, it carries an FDA warning for increased cardiovascular risk. Decision makers who were overly focused on the breakthrough potential of this research might have wasted substantial resources nurturing an area that ultimately proved to be a failure—but so would those who relied on expert opinion at the time. That said, the potential benefits of funding the next mRNA vaccine or cancer immunotherapy years earlier than we might have are large. When we can’t assume the outcome of an action, it’s worth conducting an experiment. Can targeted support for areas that are poised to produce a breakthrough increase the return on scientific investment without cannibalizing future advances? With the necessary administrative infrastructure in place, conducting this experiment would be straightforward. First, identify all the breakthrough signals between 2018 and 2023, select half at random, and commit to a decade of investment. For biomedicine, a six year window should yield about 30 topics with the potential to produce a breakthrough. Providing strong support to half of these might be accomplished for $300 million a year. That’s roughly half of the recent annual budget of the NIH Common Fund or around 20% of the fiscal year 2025 budget for ARPA-H. After five years, then again at ten, compare to see which group — the one that was actively managed, or the control — produced more breakthroughs, and on what timescale. Although we used biomedicine as an example, the same experiment could just as well be run for physics, materials science, or any other discipline. Any attempt to undertake such an experiment should keep three points top of mind. First, we can predict the topic of future breakthroughs, but the people and vision for how to move the work forward are still important. In practice, this means success requires active program managers with the expertise to develop the science and the authority to do so, including by recruiting investigators. Second, we would be wise to learn from the failures of past attempts to fund transformative research. High among these are funding modestly repackaged work, confusing the genuinely novel with the merely unfamiliar, and relying too much on incumbent investigators. All of these risks can be mitigated by thoroughly and intelligently integrating high quality data into portfolio management. Finally, we need to have patience. Even with strong funding support, producing a breakthrough takes time. If supporting breakthroughs is the best way to nurture the birth of new fields, we also need to accurately describe and properly manage the other two stages, so that we invest wisely throughout the productive lifetime of ideas and divest once they reach the point of diminishing returns. We would benefit from more study of all of these phases, especially the transition from one to another. More research could answer questions like: When does a breakthrough become an established field? How do the availability of funding, the size and characteristics of the available workforce, and the accumulation of evidence that disagrees with prevailing models affect a field’s decline? Exactly how do old ideas give birth to new ones, and can we speed up the process? The more we understand about the dynamics of scientific progress, the better we can maximize the odds that our curiosity leads to results. I’d call that finding a way to make our own luck.
Another look at carrots and eyesight; how to get more fiber; why mosquitoes bite some people and not others; plus other stories with Vanderbilt Health sources
AARP reporter Stacey Colino interviewed Milam Brantley, MD, Associate Professor of Ophthalmology and Visual Sciences, in 2020 for a story about whether eating carrots can improve vision. Sacramento Bee reporter Samantha Agate has now used Brantley’s comments in an AI-curated story created by content specialists on the same topic that has been picked up by MSN and others. Prevention magazine interviewed Heidi Silver, RD, PhD, Founding Director of the Vanderbilt Diet, Body Composition, and Human Metabolism Core, for a story about the importance of fiber and how people can get more of it in their diet. William Schaffner, MD, Professor of Preventive Medicine, was quoted by several news outlets about public health issues, including: Women’s Health (tick bites and alpha-gal syndrome); The Washington Post (tetanus); and Healthline (why mosquitoes prefer to bite some people and leave others alone). A visit to Monroe Carell Jr. Children’s Hospital at Vanderbilt by some Banana Ball baseball players was covered by The Tennessean and WZTV Fox 17 News, and The Tennessean’s story was also picked up by Yahoo! Sports. Clarksville Now published a story written by the Montgomery County Economic Development Team, whointerviewed Bradley Stancombe, MD, professor of Clinical Pediatrics, Vanderbilt Neonatology, about the new energy of Vanderbilt Clarksville Hospital and how the facility is recruiting physicians. Healio Allergy/Asthma group editorial director Richard Gawel interviewed Mark Rolfsen, MD, Clinical Fellow in the Division of Allergy, Pulmonary and Critical Care Medicine, for a story about his presentation at the American Thoracic Society meeting on metal health outcomes following ICU discharge. Nashville Scene reporter Hannah Herner interviewed James Crowe, MD, Director of the Vanderbilt Center for Antibody Therapeutics, for a story about his efforts to prepare for the next pandemic by isolating antibodies that can neutralize dangerous viruses. Medscape reporter Kathleen Doheny interviewed Neesha Choma, Associate Chief of Staff of Vanderbilt University Hospital, for a story about how hospitals can reduce readmissions.
A lack of funding, a glut of stigma: How Ohio LGBTQ+ health outcomes are impacted
For the 1 in 10 Ohioans who identify as LGBTQ+, media representation and social acceptance may have improved, but stigma and discrimination still impact them in large aspects of their lives, including healthcare access.
Healthcare Providers Look Beyond Price To Deliver Better Value
A new approach to procurement promises to not just produce much-needed cost savings but also improve outcomes for patients.
New Office at SBU Links Climate, Community and Health
Stony Brook's new Office of Health Equity and Climate Medicine Research brings together groups to better understand how the environment shapes health outcomes.
'Voicemails for Isabelle' is Netflix's latest big hit — but viewers should expect tears
Zoey Deutch's Netflix rom-com has pleased both audiences and critics alike. But what viewers weren't expecting was how many tissues they would need while watching.
Los Angeles Business Journal Names Kristen Cerf CEO of the Year
This recognition reflects Cerf’s leadership and the collective commitment across the Blue Shield Promise team to improve health outcomes and expand access to care.
Bills legend Jim Kelly provides update on condition after stroke
After beating cancer in 2019, Bills legend Jim Kelly revealed that he suffered a setback while recovering from a spring stroke.
Opinion | Michigan has a strong maternal, child health budget. We can’t afford to lose it
Strong maternal and child health systems require sustained commitment. Programs that improve outcomes only work when families can count on them being there.
HRSA Announces Maternal Health Grant Opportunity
The grant will support produce prescription programs that aim to improve nutrition access and health outcomes for pregnant and postpartum patients and their families.
Books for Better Health: Can Parent Beliefs About Reading Affect Health Outcomes?
A new research study looking at shifts in parental beliefs about books, reading frequency, and health outcomes was launched at a free Scholastic book at Yale
Oklahoma soars past North Carolina in Game 3 to win MCWS
Oklahoma capitalized on North Carolina's uncharacteristic pitching struggles and got another clutch performance from LJ Mercurius out of the bullpen on its way to victory in the winner-take-all Game 3 of the Men's College World Series finals Monday night.
Following user outcry, AMD reinstates memory encryption in consumer CPUs
Critics saw the move as an underhanded way to steer them toward more costly chips.
A New Bill Would Ban Lawmakers From Betting on Politics and Elections in Prediction Markets
CNBC’s Emily Wilkins reported last week that House lawmakers have introduced legislation that would prohibit members of Congress, their spouses, and dependent children from placing wagers in prediction markets on political, policy, or election outcomes. “House lawmakers are just dropping a brand new bill that would ban lawmakers from making any bets in prediction markets ... A New Bill Would Ban Lawmakers From Betting on Politics and Elections in Prediction Markets
Employer Priorities: Advancing Organizational and Employee Health
Employers are uniquely positioned to drive internal and external change and meaningful outcomes for employees, their businesses, and surrounding communities thr
Athlete of the Year finalist: \'Clutch\' three-sport standout left legacy of winning at Manheim Township
The number is simply staggering.
Poll: Americans draw a new line in the betting bonanza sweeping over Wall Street
A plurality of Americans believe betting on election outcomes should be illegal, The POLITICO Poll finds.
First Business Bank Funds $1MM Factoring Facility for Transportation Company Growth
First Business Bank’s accounts receivable financing team recently closed a $1 million factoring facility to support the continued growth of a transportation
First Business Bank Funds $1MM Factoring Facility for Transportation Company Growth
First Business Bank’s accounts receivable financing team recently closed a $1 million factoring facility to support the continued growth of a transportation
Mila Kunis says she doesn't want marriage to Ashton Kutcher to stop evolving
"Our fundamentals, our foundation, everything is built on respect because we've known each other since I was 14 and he was 19," Mila Kunis said.
Why Not US? Can Pochettino's USMNT Win It All, Curaçao's Miracle & Dutch Dominance
There are higher colon cancer rates among people of Cajun descent. Here’s what doctors are doing to help.
Learn about the significance of colonoscopies in detecting and preventing colon cancer, especially in high-risk populations like the Cajun community in Louisiana. Early screenings can save lives and improve outcomes.
Long Marches, Heat Struggles for Houston’s World Cup Visitors
“We are not used to these temperatures,” one Dutch fan told FOS.
New Listening Mothers survey: Pregnant patients struggling on Medicaid
A national maternal health survey found many mothers felt unheard during pregnancy and birth, with Medicaid patients reporting worse outcomes.
U.S. scientific instruments in oceans off Alaska and elsewhere to remain in place
After a public outcry and a unanimous Senate vote, the National Science Foundation dropped plans to remove parts of the Ocean Observatories Initiative system.
U.S. scientific instruments in oceans off Alaska and elsewhere to remain in place
After a public outcry, the National Science Foundation dropped its plan to remove much of the Ocean Observatories Initaitive system.
Conservatives are dying at higher rates than liberals. A new study points to mistrust in medicine
The health divide emerged over the last decade and has widened since 2020, according to research that links ideology to outcomes from heart disease, cancer, stroke, and other internal causes.
Raiders’ Klint Kubiak shuts down Kirk Cousins-Fernando Mendoza narrative
Las Vegas Raiders coach Klint Kubiak made his stance clear on the quarterback competition between Kirk Cousins and Fernando Mendoza.
National Science Foundation reverses decision to dismantle oceans-monitoring network after outcry
The National Science Foundation issued a statement Thursday saying that it “appreciates the concerns raised by the range of stakeholders” and would halt efforts to remove or disable equipment.
Video: A Small Election Could Change British Politics
Voters in the northern English district of Makerfield cast ballots on Thursday to choose their representative in Parliament, the outcome of which could lead to Prime Minister Keir Starmer’s ouster.
National Science Foundation reverses decision to dismantle oceans-monitoring network after outcry
The NSF issued a statement saying it would halt efforts to remove or disable equipment.
National Science Foundation reverses decision to dismantle oceans-monitoring network after outcry
The Trump administration has reversed a plan to dismantle a sprawling ocean monitoring network after vigorous objections from Democratic lawmakers and scientists.
NM spent nearly $844M on behavioral health, but 'investment is not yet matching the outcome'
New Mexico has spent $843.5 million since 2022 to rebuild state’s behavioral health system but still faces problems.
Time, Outcomes, Adoption, Cost: The Four Metrics Redefining Digital Health
Despite rapid innovation, many healthcare organizations still struggle to translate new care models into system-wide impact.
Saving the trees: Decades of work lead to UTC faculty publication in Science
The first American chestnut tree Dr. Hill Craddock ever saw was one he grew himself. He was about 15 years old, working out of a small greenhouse his father built beside their home. A neighbor gave him a handful of chestnut seeds and suggested Craddock try growing them.
How Brunson's clutch scoring can lead the Knicks to a repeat title + does Giannis to the Heat make any sense?
How good (or bad) can it get? The best- and worst-case scenarios for every NFL team in 2026
Can the Cowboys finally break through? Will Patrick Mahomes regain his MVP form? Here are the dream and nightmare outcomes for your favorite team this fall
Merchants of Doubt and the attacks on Extreme Event Attribution science
Last week, I attended a meeting at Columbia University on attribution science and climate law, hosted by the Sabin Center. It was a fantastic event, bringing together scientists and legal experts working at the intersection of extreme event attribution and climate law. Subscribe For those unfamiliar with it, extreme event attribution attempts to quantify the contribution of climate change to an extreme event. For example, several groups analyzed the impact of climate change on Hurricane Harvey’s enormous rainfall totals over Houston, Texas and they found that climate change increased rainfall by 15 to 38%. One thing that came up again and again was how terrified fossil-fuel interests are of extreme event attribution science. They are acutely aware that this research could land them in court. And losing those cases would leave them legally liable for billions of dollars in climate damages. Because the legal stakes are so high, the blowback has turned ugly. I spoke with several scientists at the meeting who are facing ongoing harassment over their work. This blowback is a coordinated campaign to make the entire field look suspect. The goal is to create the impression that attribution science is too uncertain, too political, or too conflicted to be useful in court or in public policy. The strategy is not based on actual science or evidence of misconduct, but on the generation of doubt. The new Merchants of Doubt We’ve seen this before. In fact, not that long ago: We only have to go back a year to the Department of Energy (DOE) Climate Working Group (CWG) report to see an example of using doubt as the tool to push back against well-established science. This strategy is laid out in an email from a member of the CWG, Dr. Roy Spencer, that was released during litigation over the Climate Working Group process. The key quote is: About all I can hope is that what we write will provide sufficient “reasonable scientific doubt” regarding the science claims in the 2009 TSD [technical support document], based upon almost 2 decades of new science, to call into question the original reasoning for the EPA Administrator’s decision that CO2 presents a threat to human health and welfare. This statement is strong evidence that at least some members of the committee were working to support a particular policy outcome: revoking the Endangerment Finding. The email also explains how they planned to do it: by attempting to generate “reasonable doubt”. This is going to be hard, Spencer implies. Despite falsely claiming that “2 decades of new science” weakens the case, Spencer explicitly acknowledges that the actual peer-reviewed science of climate change overwhelmingly rejects his position: But if the science argument is decided upon by a vote, or by the number of published citations, we lose the science argument. We can go back even further: This CWG email shares unmistakable DNA with the infamous 1969 tobacco memo that declared: “Doubt is our product, since it is the best means of competing with the ‘body of fact’ that exists in the mind of the general public. It is also the means of establishing a controversy.” The tobacco memo also acknowledges the limit of this strategy: Like the CWG, they knew the science was not on their side. Share The new new Merchants of Doubt The people attacking the IPCC chapter on extreme event attribution are the newest iteration of the Merchants of Doubt. Their goal, like all Merchants before them, is to introduce doubt into the process. Because the report is not even out yet, they cannot attack its conclusions. So they are attacking the authors instead. Here is a press release from the House Science, Space, and Technology Committee: In the letter, the Chairmen express concerns about potential conflicts of interest involving members of the Attribution Committee, stating that “publicly available information suggests a troubling pattern” in which committee members are affiliated with nonprofits that support climate accountability lawsuits, “raising the appearance of impropriety and member bias.” To be clear, this is just innuendo. There is no actual evidence of bias. And given the robust process that these reports go through, including multiple lines of peer review, it seems very unlikely that significant bias can survive into the report. When the report comes out, critics will have the opportunity to make legitimate criticisms of the report — if any exist. If none do, however, they’ll still make criticisms, but they’ll be bogus, simply designed to generate doubt. We’ll see. A note to the press: Fix your frame To any journalists reading this: The public debate over extreme event attribution science is not going away. The science is simply too dangerous to fossil-fuel interests for them to stop fighting it. You very well might be assigned to write an article about this area of research in the future. When you do, do not automatically adopt the framing that climate misinformers want you to use. They want you to frame the story around questions like: Are climate scientists trying to put their thumb on the scale to achieve a predetermined, politically motivated result? Are climate scientists improperly letting their politics invade the science of the IPCC? That frame is a trap. Instead, you need to view this through the historical lens of the Merchants of Doubt. How does the ecosystem of doubt operate? Who funds it? What methods do they use to misrepresent science and slime researchers? What scientific results are they trying to keep people from understanding are legitimate? Ultimately, you instead need to focus your article on the generation of doubt as a way to maintain the fossil fuel industry’s social and legal license to keep burning oil, gas, and coal. If you treat the misinformers’ frame as a legitimate, good-faith scientific critique, you are helping them produce doubt. Don’t do it. Don’t be a Merchant of Doubt. Thanks for reading The Climate Brink! Subscribe for free to receive new posts and support our work. Subscribe other stuff The Staying Curious Substack has an interesting post about the different flavors of climate sensitivity. This is crucial information if you want to understand how scientists think about how much warming the Earth will experience. I’d be grateful if you could hit the like button ❤️ below! It helps more people discover these ideas and lets me know what’s connecting with readers.
Health Outcomes Data For Wearables Key To Medicare Coverage Expansion
Insurance coverage of wearables is spotty. This could soon change as Medicare begins a pilot to facilitate access to wearables while gathering data on health outcomes.
Apptio Unveils Conversational Insights and New Suite of AI-Powered Capabilities to Translate Complex Technology Spend into Measurable Business Outcomes
Apptio announced significant updates to its solution suite designed to turn technology investment into measurable business outcomes and establish best practices for the financial governance for AI in a time of record infrastructure investments.
Miguel Rojas' pinch-hit homer lifts Dodgers past Rays
LOS ANGELES — The crowd of 53,911 at Uniqlo Field at Dodger Stadium has seen its share of dramatic moments over the years, but on Monday night, Miguel Rojas added another memorable chapter to his growing collection of clutch performances.
Dutch children are unusually happy and healthy. Is it because of the Avondvierdaagse?
Once a year, Dutch kids, parents and teachers take part in a walking festival, heading out for four nights in a single week to explore their neighbourhoods, exercise and make friends. It’s a tradition that seems to be genuinely transformative
NBA Finals 2026: Did Jalen Brunson just author the most clutch playoff run in NBA history?
Turner on Addressing Poor Mental Health Outcomes of Black and Latino Boys
Assistant professor of social welfare David C. Turner III argues that still more needs to be done to address the structural issues impacting the mental health outcomes of Black and Latino boys
From Managing Processes to Driving Outcomes: Oracle’s Latest AI Push Aims to Rewire Business
With a new class of enterprise applications that execute end-to-end processes, Oracle is showing how enterprise software has evolved from tracking work to driving outcomes.
Shimano Reinvents Deore Group With New Brakes and Cable-Actuated Drivetrain
Three new derailleurs, all cable-actuated, one with a clutch.
Why Marketing Feels Harder as Your Business Grows by Nathan Tayloe
At some point, most growing businesses hit the same moment. What used to feel straightforward starts to feel more complicated. Marketing takes more effort. Results feel less predictable. What once worked consistently begins delivering mixed outcomes. It is easy to assume something is broken. In many cases, nothing is. The business has simply reached a different stage. What Worked Before Starts to Lose Its Edge Early on, growth is often driven by a few things working well at the same time: Referrals are strong The value of the offering is clear The team is aligned Decisions are made quickly Marketing, in that stage, tends to feel easier because the business itself is easier to understand. As the company grows, that simplicity fades. The audience expands. Services evolve. New people join the team. More channels are added. More decisions are made across more touchpoints. Marketing is no longer communicating one clear story. It is trying to represent a more complex business. Complexity Creates Friction That added complexity does not always show up immediately. It builds over time. Messaging starts to drift. Different parts of the business describe what they do in slightly different ways. The website no longer reflects how the company actually operates. Sales conversations evolve faster than the brand. At the same time, more activity is introduced to try to keep growth moving: New campaigns More content Additional platforms More tools and reporting The volume increases. The clarity does not always keep pace. That is when marketing starts to feel harder. It’s Not a Lack of Effort Most teams respond to this stage by doing more. More output More meetings More adjustments More experimentation That effort is not misplaced. It is often pointed in the wrong direction. When the underlying issue is a lack of alignment, more activity tends to create more noise. Results become harder to interpret. Decisions take longer. Progress feels inconsistent. From the outside, everything looks active. From the inside, it feels less certain. The Real Shift As businesses grow, marketing becomes less about execution and more about alignment. The companies that navigate this transition well tend to refocus on a few fundamentals: A clearly defined audience A strong, consistent position in the market Messaging that reflects how the business actually operates Alignment between leadership, marketing, and sales When those elements are in place, execution becomes more effective again. Marketing does not necessarily become easier, but it becomes more consistent. A Different Kind of Discipline Growth introduces more opportunity, but it also demands more discipline. What worked when the business was smaller often cannot be scaled without adjustment. The systems, messaging, and decision-making that once felt intuitive need to become more intentional. That is not a sign of failure. It is a normal part of growth. Marketing feels harder because the business has become more complex. The solution is not to outwork that complexity. It is to bring clarity to it. The companies that do that well tend to regain momentum quickly. Those who do not often stay busy without seeing the same level of progress. — Learn more about how we help organizations align strategy, brand, and execution. Visit tayloegray.com, or reach out directly at nathan@tayloegray.com.
Patriots rumors: Will Kayshon Boutte’s dominant minicamp change trade status?
Patriots wide receiver Kayshon Boutte has been on the trade block, but a big minicamp has given New England a tough choice to make.
The Netherlands’ completely mad run 🇳🇱🔥
The Netherlands are about to begin their World Cup campaign, against Japan.In their last appearance in 2022, the Dutch were knocked out by Argentina on penalties. A legendary quarter-final that has r...
Report finds deep racial and ethnic health disparities in Texas
We examine the Commonwealth Fund report's findings and what they reveal about health care access, affordability and outcomes across Texas.
Knicks vs. Spurs NBA Finals: Victor Wembanyama and San Antonio may have arrived ahead of schedule, but the pain did as well
'Let the candidates mix it up.': Ron DeSantis keeps pressure on Evan Power for GOP gubernatorial debate
'These ridiculous criteria are being used to renege on that promise and to engineer a preferred outcome.'
Mysterious Predator That Butchered Ancient Birds Is Finally Unmasked
Terror in the skies.