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Former Microsoft engineer left $200K job to build AI startup solo
Junead Khan left Microsoft after two years to pursue his AI startup. He explains why he quit his six-figure job without customers or VC funding.
Sunday Night Football: How to watch the Baltimore Ravens vs. Atlanta Falcons game tonight
How Brewers phenom Jacob Misiorowski went from 'baby giraffe' to Cy Young lock
U.S. Department of Health and Human Services (HHS) Recommends Science-Based Thresholds to Target Dangerous Enhanced Kratom Products
Kratom products credit: CDPH DEA takes action based on updated recommendation from HHS October 11, 2026 - WASHINGTON - On Friday, the U.S. Department of Health and Human Services relesed the following: The U.S. Department of Health and Human Services (HHS) provided a new recommendation to the Drug Enforcement Administration (DEA) that establishes science-based thresholds for 7-hydroxymitragynine (7-OH) and mitragynine pseudoindoxyl (MGPI), potent opioid compounds associated with products marketed as kratom. The Department of Justice today announced that DEA issued new Notices of Intent reflecting HHS’ updated scientific analysis and recommendations, including a new Notice of Intent for 7-OH and MGPI incorporating HHS’ recommended concentration and ratio thresholds. Following a review of available scientific data and comments, HHS Assistant Secretary for Health Admiral Brian Christine, M.D., recommended that DEA use concentration or ratio-based thresholds to determine which products containing 7-OH and MGPI are subject to Schedule I control for purposes of temporary scheduling of these substances under the Controlled Substances Act. The recommendation is designed to target concentrated or chemically altered products while distinguishing them from natural botanical kratom products, which may contain trace amounts of 7-OH and MGPI. “We are drawing a clear line between natural kratom and dangerous, enhanced opioid products,” said HHS Secretary Robert F. Kennedy, Jr. “We listened to the public, followed the science, and developed a clear recommended threshold for temporary scheduling that targets concentrated 7-OH and MGPI without sweeping natural botanical kratom into Schedule I. The Trump Administration will continue taking decisive action against dangerous products that fuel addiction while making sure our policies are grounded in rigorous science.” Under the recommendation, 7-OH and MGPI would be controlled in Schedule I for purposes of temporary scheduling when either substance alone, or their combined amount when both are present: Exceeds 1 milligram per gram in solid powders, encapsulated material, or other solid forms, or exceeds 1 milligram per milliliter in liquid preparations; or When the mass of mitragynine present divided by the mass of 7-OH, or MGPI, or the combined amount of 7-OH and MGPI if both present, is less than 100. The ratio-based approach reflects the alkaloid composition of natural kratom products and provides a way to identify products intentionally enhanced or concentrated with 7-OH or MGPI. Available scientific data indicate that 7-OH occurs naturally in botanical kratom at relatively low or trace levels, while some evidence reviewed by FDA suggests MGPI may also occur at trace levels in some natural or kratom-derived products. FDA's scientific review found that 7-OH is substantially more potent than morphine in preclinical studies, with available data indicating approximately two to nine times greater potency depending on the study. FDA also identified evidence supporting a meaningful risk of opioid-like physical dependence and withdrawal from MGPI. “Our recommendation gives DEA a scientifically supportable framework to distinguish natural botanical kratom from products that have been concentrated or manipulated to deliver dangerous levels of potent opioid compounds,” said Assistant Secretary for Health Admiral Brian Christine, M.D. “This approach allows us to focus on the products that pose the greatest threat to public health.” In July 2025, following an FDA scientific and medical evaluation, HHS recommended that 7-OH above a specified threshold be placed in Schedule I of the Controlled Substances Act. In July 2026, DEA announced its intent to temporarily schedule 7-OH above a specified threshold, and HHS simultaneously sought public comment on the proposed threshold. DEA subsequently temporarily placed MGPI and two synthetic 7-OH derivatives, MGM-15 and MGM-16, in Schedule I. Since then, questions have emerged about how scheduling could affect natural botanical kratom products potentially containing trace amounts of MGPI. The new HHS recommendation responds to those concerns by providing DEA with a more precise threshold based on both the concentration of 7-OH and MGPI and their relationship to mitragynine, the predominant alkaloid in kratom. HHS and FDA will continue working with DEA to protect Americans from dangerous concentrated and synthetic opioid products while ensuring federal policy is grounded in the best available science. Source: HHS
Personal AI agents threaten companies profiting from consumer inertia
Personal AI agents are helping users lower bills and get refunds, exposing companies that rely on customers doing nothing.
Heat Your Garage During Cold Months With A Wi-Fi Enabled Solution From Home Depot
The HEAT STORM Ceiling Mounted Hardwired 240-Volt Garage Heater comes with Wi-Fi controls that let you customize your heating remotely.
Here's when to get your flu shot
Here's what to know about common flu symptoms, why the illness can become dangerous and when to get vaccinated.
A father used Muse to prep his son for a quiz. He aced it.
Franco Lopez asked Meta's Muse AI agent to help his son prepare for an astronomy quiz. It made him flashcards and a custom podcast.
One income, two retirements: How couples can protect their future
Single-earner families should look beyond today’s budget and consider retirement savings, emergency funding, workforce reentry, and future Social Security benefits.
White Sox break their own 3-day old MLB postseason record with 21 strikeouts in season-ending loss to Guardians
Inside Texas Politics: Dallas County Republicans trying to win back commissioners court seat
O’Mara Named 2026 ‘Guardian of Small Business’
Big Flats Senator Tom O'Mara earned the 2026 'Guardian of Small Business' award. He's one of five senators with a 100% NFIB voting record.
Yahoo Top 10: After a tumultuous day of upsets, Georgia left no doubt as to who's No. 1 with win over Alabama
The Preliminary Lunar Science Report for Artemis II is Out!
Through photographs, spoken observations, drawings, and annotations, the Artemis II crew created a unique scientific record—one that is now available to the science community and the public for further study. Explore highlights here, and find the full suite of reports and select data resources at the bottom of the page.
International Business Machines (IBM) Unveils Real Time App Security Collaboration
International Business Machines (NYSE: IBM) announced a new collaboration with Zscaler and Red Hat to tighten application security for enterprise clients. The joint effort combines IBM and Red Hat software platforms with Zscaler threat intelligence to provide real-time protections at the application layer. The partners plan to coordinate vulnerability discovery, automated policy updates, and validated software remediation workflows for shared customers. This IBM, Zscaler and Red Hat security...
Misery Index: Mike Elko's bizarre rant about Texas A&M fans couldn't come at a worse time
Vikings Make Several Roster Moves Ahead of Saints Game
A handful of changes before tomorrow’s game
MLB playoffs 2026: NLCS, ALCS matchups, schedule and start times
Health advisory issued for Toms Bayou in Valparaiso following wastewater release
Officials emphasized that local drinking water is not affected.
Georgia vs. Alabama score, live updates, highlights: Follow SEC showdown after Hurricane Isaias
White Sox vs. Guardians live updates, lineups, where to watch: Sean Burke, Gavin Williams to start Game 5
Starbucks lawsuit puts sugary drinks in spotlight as doctor warns of health risks
Dr. Michael Aziz, an attending physician at Lenox Hill Hospital, discusses the sugar content of specialty coffee beverages amid litigation involving Starbucks, with estimates reflecting specific sizes and customizations.
Vasco and Remo name line-ups for São Januário clash
Vasco and Remo have named their lineups for this Saturday's (10) Brasileirão clash at São Januário.Both teams are in the bottom half of the table, but are in contrasting form.Vasco have won three s...
Your Mental Health: Simone Biles opens up about skin condition
The itching, visible symptoms and uncertainty can take a toll on sleep, confidence and mental health.
Tom Welling reveals ‘Smallville’ costar John Glover once showed him a fan-made nude
During New York Comic Con, Tom Welling shared that his ‘Smallville’ costar John Glover gave him a fan-made nude to sign during the show’s run.
Crews begin clearing 169 trees at DC golf course Trump plans to convert to championship course
The East Potomac Golf Course is home to one of several Trump administration renovation projects wrapped up in litigation brought by preservationists.
SF mayor admits city ‘lost its way’ by embracing ultra-left ideology
Arbeloa 'doesn't feel fear' but pressure increases after loss
Fulham boss Alvaro Arbeloa says he does not 'feel fear' after defeat at Ipswich left his side winless in six games and bottom of the Premier League.
REO Town businesses forced to adapt amid economic slowdown
Small businesses in Lansing’s REO Town are adapting to economic challenges by shifting toward experiential services and receiving grants to attract customers, even as some local establishment…
Experts warn of early flu season as 2 flu-related deaths reported in Western Washington
Warriors sign Brandin Podziemski to extension worth reported $110M
The Picklr files for bankruptcy, plans reorganization
Pickleball facility franchisor The Picklr has filed for Chapter 11 bankruptcy, with committed financing from a group led by former MLS team exec Tom Neale.
Stomach-turning sexually transmitted infection is on the rise — and standard medicines are failing
Shigella bacteria are becoming harder to treat as drug-resistant strains rise, and doctors warn Americans should be concerned but not panicked.
College football scores, live updates: Indiana vs. Nebraska, Texas A&M vs. Missouri and more
Jaguar reveals a $130,000 all-electric vehicle. Why?
At a darkly lit event in a Manhattan warehouse this week, actress Florence Pugh, Knicks player Karl-Anthony Towns as well as throngs of influencers all gawked at Jaguar Type 01, the British automaker’s first new model in nearly a decade.
Amazon’s new Alexa Tablet finally gives the iPad lineup some much needed competition
This week, Amazon unveiled a new lineup of Alexa Tablets. They no longer run a proprietary OS with a custom...
A subtle symptom in your fingernail could be a sign of congestive heart failure, cancer, psoriasis
5 Samsung Galaxy features you should be using after updating to One UI 9
Android 17 and One UI 9 have brought new features to Samsung phones. Users can get security alerts and custom Now Briefs, and the Quick Panel has new tricks.
Tom Izzo Loses Top-40 Recruit to SEC Powerhouse
Michigan State basketball misses out on four-star center Kamsi Awaka, who committed to Florida. Here's what it means for Tom Izzo's 2027 class.
Will Citi Upgrade Change Flutter Entertainment (FLUT) Stock Narrative
Flutter Entertainment confirmed that Chief Legal Officer Don Liu resigned at the end of September 2026, with Group Company Secretary Edward Traynor stepping in as interim legal head. FanDuel continues to show solid customer and handle momentum during the early NFL season. The same period combined legal leadership turnover, regulatory pressure in Brazil that led to a shutdown of operations there, and higher UK gaming taxes with ongoing cost transformation and heavy US investment. This...
Fabregas: “Roma are great, but we will do our best.”
It’s also a tough day at Como. Tomorrow, the Como side will face Gian Piero Gasperini’s Roma in the lunchtime match of Serie A’s sixth matchday, when the season resumes after the international b...
What’s Dragging Down A.I. Efficiency? The ‘Verification Tax.’
As artificial intelligence automates office tasks, it is also creating a new type of human work.