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A landmark cosmic project will reveal new truths about the universe
The Legacy Survey of Space and Time has begun, and a Northeastern physicist is helping search for the universe's dark matter and energy.
NC State Health Plan raises premiums, offers new tiered benefits that could help members cut costs
The N.C. State Health Plan's Board of Trustees voted Friday morning to raise premiums for many of its 770,000 members.
Deal with developer could lead to new sports stadium in Rochester
Rochester’s city council unanimously approved an exclusive agreement with Wisconsin-based Landmark Development. It gives the company six months to decide if it wants to build a facility on a piece of city-owned land downtown.
Chargers Receive Honest Admission on Edge Rusher Dilemma
As Khalil Mack prepares to pass the torch, rookie sensation Akheem Mesidor joins forces with breakout star Tuli Tuipulotu to solidify a high-stakes defensive evolution in L.A.
Goldman bans staff from participating in finance, politics prediction markets, source says
Wall Street giant Goldman Sachs has barred employees from trading on prediction-market contracts linked to financial markets and political events, a source familiar with the matter said on Thursday.
Wall Street giants bar staff from finance and politics prediction markets, source says
July 9 (Reuters) - Wall Street giants Goldman Sachs and Morgan Stanley have barred employees from trading on prediction-market contracts linked to financial markets and political events, a source familiar with the matter said on Thursday. A memo was ...
Goldman Bans Staff Prediction Markets Bets on Finance, Politics
Goldman Sachs Group Inc. has banned employees from trading on prediction markets except for sports and entertainment bets, in one of the most pointed efforts by a Wall Street firm grappling with the new regulatory issues raised by the boom in betting on events.
Trans athletes drop lawsuit to gain access to girls' sports in New Hampshire after SCOTUS ruling
Trans athletes Parker Tirrell and Iris Turmelle dismissed their lawsuit challenging the state law after the Supreme Court's landmark Title IX ruling.
Center for Sports Media Caps Landmark Year of With Unprecedented Oppor
Seton Hall University’s Center for Sports Media concluded the 2025-26 academic year with expanded industry partnerships, national event coverage and one-of-a-kind experiential learning opportunities.
Texas Theatre Leads the Future of Cinema with Hybrid Programming
Theatrical programmers from coast to coast draw inspiration from the Dallas landmark.
Digital Twin in Entertainment Market worth $2,533.2 million by 2032
According to MarketsandMarkets™, the global Digital Twin in Entertainment Market is expected to grow from USD 492.4 million in 2026 to USD 2,533.2 million by 2032, growing at a CAGR of 31.4%
Vendors, food and entertainment return for 53 Art in the Park
West Lincoln Part will come to life this weekend with live music, tasty delights, a beer tent and 153 vendors selling handmade goods and arts from across the region. The ironic event is celebrating its...
News | Beyond the Rodeo: Calgary Stampede bets on becoming year-round entertainment district
Hotel project underway at Calgary's Stampede Park as landmark event takes place
How North Dakota Finally Built Theodore Roosevelt's New Library
Doug Burgum, Kelly Armstrong and Kevin Cramer discuss the state's biggest new landmark and the politics of the moment.
Women’s sports is booming. The LPGA is finally figuring out how to be a part of it
The new commissioner has reinvigorated players, secured landmark sponsorship deals and has pieces in place to revamp the LPGA’s schedule.
Reflecting Pool being drained – again – as Trump administration tries once more to fix landmark
Crews began draining the Lincoln Memorial Reflecting Pool on Sunday, according to Interior Secretary Doug Burgum, for the second time in three months.
Sources: Big 12 strikes landmark Monster deal featuring jersey patches, field logos
The Big 12 finalized a multiyear deal worth around $20 million annually making Monster the entitlement partner of its football and basketball regular seasons.
Inside the BoF and Clinuvel Community Lunch Exploring the Future of Skin Health
Investors from Goldman Sachs, L Catterton and Bansk Beauty joined leaders from L’Oréal, Harrods, Space NK and Unilever at The Business of Beauty Global Forum to examine how advances in medicine, biotechnology and longevity are redefining the future of skin health.
Inside the BoF and Clinuvel Community Lunch Exploring the Future of Skin Health
Investors from Goldman Sachs, L Catterton and Bansk Beauty joined leaders from L’Oréal, Harrods, Space NK and Unilever at The Business of Beauty Global Forum to examine how advances in medicine, biotechnology and longevity are redefining the future of skin health.
Caesars vs. Six Flags: Which Leisure Entertainment Stock Is a Better Buy in 2026?
One faces a $17.6 billion buyout with mounting losses; the other is trimming assets post-merger while bleeding cash.
Stock Market Today, July 6: AMC Entertainment Falls as Share Sales Complicate Summer Box Office Rebound
AMC’s recent share sales improved liquidity, while stronger theater traffic now needs to show up in margins and balance-sheet progress.
Young entrepreneurs to run businesses at Hampstead Youth Farmers’ Market
Entrepreneurs aged 5-17 will sell handmade goods and learn business skills at the third annual Hampstead Youth Farmers’ Market.
About 2K pounds of copper stolen from Boardman business: Report
Police are investigating the reported theft of about 2,000 pounds of copper banding that was stolen from a Boardman business.
The Elder Scrolls Online Team Seemingly Gutted By Xbox Layoffs, Says Game's Roadmaps 'Will Be Shifting'
However, its community manager has said those remaining want to 'reaffirm our commitment' to the game
'Fighter for everyday Floridians': Tina Polsky becomes latest lawmaker to endorse Alex Vindman
'Alex has called out corruption at the highest levels of government.'
Areta Crowell: Behavioral Health Leader
In 1967, the California Legislature overwhelmingly approved the Lanterman Petris Short Act, which sped the emptying of state hospitals. Areta Crowell lived the origin story of that landmark law. Her job was to implement the law in Los
Colorado needs an Independence Day
Happy 250th Birthday, America! You look fabulous. As all the cool countries are saying, “250 is the new 230.” The Declaration of Independence wasn’t merely an announcement of war against a tyrant. It was the most revolutionary political document ever written. The Declaration was a landmark in human development, perhaps the landmark of all human […]
See iconic Sarasota photos from a bygone Florida era
From Ringling elephants and the Lido Beach Casino to downtown landmarks, these vintage photos capture the magic of old Sarasota.
Overnight News Digest: Star Spangled Science Saturday, 7/4/26
Welcome to the Overnight News Digest with a crew consisting of founder Magnifico, regular editors side pocket, maggiejean, Chitown Kev, eeff, Magnifico, annetteboardman, Besame, jck, JeremyBloom…
Yankees potential trade partner: Colorado Rockies
Hunter Goodman the biggest name in play, with several impact arms most likely to be moved.
Goldman dominates first-half M&A as dealmaking surges in EMEA
Goldman Sachs increased its share of mergers and acquisitions advisory work involving Europe, the Middle East and Africa in the first half of 2026, capturing the biggest slice of the market in the period for nearly a decade, LSEG data showed.
Goldman Sachs economist predicts AI displacing 15 million jobs
Joseph Briggs of Goldman Sachs foresees AI displacing 15 million US jobs, but suggests new roles will emerge as adoption progresses.
As Mamdani pledges transparency for 9/11, lawyers say some records weren't saved
A spokesperson for Mamdani said the portal will have millions of documents.
Trump's 'hero' justice offers roadmap after Supreme Court rejects birthright order
Justice Kavanaugh's concurrence outlines how Congress could legislatively restrict birthright citizenship, sparking immediate Republican action.
Two different parties, two strikingly similar immigrant stories. Lawmakers from both parties share what being American means
Alex Vindman raised $8.5M for Senate run, beating own first quarter totals
The Democrat aims to unseat Ashley Moody in November.
Maryland's first 'human composting' facility is open for business
Maryland's first 'human composting' facility is turning human remains into soil, considered a greener alternative to cremation or traditional burial
Americans step out for their nation's 250th in a proud moment sown with division and doubt
America has come to a landmark moment of pride and patriotism — and a time of division and doubt
California trucking business files for bankruptcy
Commodity Transporters initiated the Chapter 11 petition.
MD lawmaker's historic journey unfolds in book that's part autobiography, part political memoir
Maryland lawmaker, Lily Qi, writes about her journey from China to the US and into state politics in a book that's part autobiography, part political memoir
Multnomah County Just Fired a Key Health Leader. He Says He’s a Scapegoat in a Power Struggle.
Anirudh Padmala’s departure marks worsening tumult in the top leadership overseeing the network of 19 federally-funded Portland area clinics, which collectively serve tens of thousands patients annually.
'Save Women's Sports' legal defense and trans athlete's attorneys speak out after landmark SCOTUS ruling
Idaho Attorney General Raul Labrador and West Virginia Attorney General JB McCuskey praise the ruling as a victory for fairness in women's sports.
How 'Bad Santa' brought naughty Billy Bob Thornton onto 'Landman'
If you've ever thought that you'd seen Billy Bob Thornton's Tommy Norris before, you're jolly right. The "Landman" central character is the spiritual cousin to Thornton's infamous role as Willie
Goodman: He could have been an international spy, but chose a different path
The soccer culture of Birmingham, Alabama, that produced Chris Richards has an unlikely origin story.
Bullpen blows it as Rockies fall to Marlins 10-7
Hunter Goodman hits 26th HR as his hot June continues
Thomas, Gorsuch target landmark ruling Trump says protects the 'fake news'
Clarence Thomas and Neil Gorsuch call for overruling New York Times v. Sullivan in their dissent over the CNN-Dershowitz defamation decision.
Supreme Court won't revive Alan Dershowitz's $300 million suit against CNN
Dershowitz had urged the court to reconsider New York Times Co. v. Sullivan. The landmark First Amendment case that made it harder for public figures to win libel lawsuits because it requires proof that an outlet knowingly published something false, or showed a reckless disregard for the truth.
Betsy Fischer Martin Will Lead Harvard’s Institute of Politics
The Emmy-winning journalist was a mainstay of political coverage at NBC for two decades.
RedMagic officially confirms global launch of flagship OLED tablet
RedMagic has confirmed the Astra 2 as its next flagship gaming tablet. The device will arrive as the international version of the China-bound RedMagic Gaming Tablet 5 Pro, which is confirmed to feature a 185Hz OLED display and the Snapdragon 8 Elite Gen 5 chipset.
Philippe Stern, Heir to the Patek Philippe Watch Brand, Dies at 88
In an era of electronic timepieces, he marketed $40,000 handmade watches as status symbols, breathing new life into a struggling industry.
Penguins organizational outlook heading into free agency
It ended up being a mostly uneventful draft weekend for the Pittsburgh Penguins. They acquired Hendrix Lapierre for draft picks, used some of their stockpile future of picks to get extra 2026 mid-round selections and went about their business of drafting players without many fireworks going down with massive moves. The big landmark for the […]
Assessing the claim that the U.S. government is abandoning science
The people who do not trust science today would probably like to be able to. And the people who do trust it may simply be unaware of the problems.
‘Handmaid’s Tale’ Star Shares The Text Elisabeth Moss Sent After Trump Won — And Fans Will Recognize It
The actor recalled texting Moss, “What are we going to do? This can’t be.”
Hunter Goodman smashes three home runs vs. Twins
Colorado Rockies designated hitter Hunter Goodman hit three long home runs against the Minnesota Twins on Saturday. Goodman crushed two no-doubters — solo shots in the first and third innings — in his first two at-bats against Twins starter Mike Paredes. Then, after grounding out in the fifth, Goodman came up with two runners on base and the Rockies leading 3-2 in the seventh.
Back in business: Blue and White Snack Bar owners vow to uphold tradition of Hollidaysburg mainstay
HOLLIDAYSBURG — A local Hollidaysburg landmark is back as Blue and White Snack Bar, 905 Union St., reopened for business May 12. “The Blue and White is a landmark in Hollidaysburg and really all of Blair County. To say that people are excited to see it open again is an understatement,” Mayor Chad Repko said. […]
Community Market Series creates space to support small business
A new market in Boardman is hoping to bring the community together to help support small, local businesses.
Vancouver turns its Science World museum into a giant 17-story soccer ball for the World Cup
It started with a whimsical idea. Why not transform the landmark Science World museum in downtown Vancouver, the geodesic dome-topped building not far from BC Place stadium, into a gigantic 17-story soccer ball for the World Cup?
Vancouver turns its Science World museum into a giant 17-story soccer ball for the World Cup
It started with a whimsical idea. Why not transform the landmark Science World museum in downtown Vancouver, the geodesic dome-topped building not far from BC Place stadium, into a gigantic
Ducks move into first round, select skill in Klepov, Nordmark
Anaheim jumped back into the first-round with two picks acquired in the Mason McTavish deal, and the Ducks went for scoring punch in Nikita Klepov and Marcus Nordmark.
Screen time can damage under-twos’ development, landmark study suggests
Exclusive: Researchers call for urgent investigation of risks to babies of tablets, smartphones and other digital devices
Rangers Land 37-Goal Star In Blockbuster Trade With Vegas
The New York Rangers have added a new star forward to their roster.According to TSN’s Darren Dreger, the Rangers have acquired forward Pavel Dorofeyev from the Vegas Golden Knights.Sportnet’s Elliotte Friedman later added that the Rangers are sending the 26th pick of the 2026 Entry Draft, the 92nd pick of this year’s draft, and their […] The post Rangers Land 37-Goal Star In Blockbuster Trade With Vegas appeared first on HEAVY.
We almost had a smartphone in the 90s. Why did it fail?
In the early 90’s, a company called General Magic began working on a portable device that would allow people to check email, make phone calls, even play games. It was basically a smartphone. But it never caught on.On today’s show, a theory about why this device failed. General Magic had generous investors, world-class talent and creative freedom. But is it possible what they needed was constraints?Support:Planet Money+Read: Our book: Planet Money: A Guide to the Economic Forces That Shape Your Life Our weekly longform Planet Money newsletterOur weekly Indicator round-up newsletterFollow: InstagramTikTokYouTubeFacebookThis episode was hosted by Erika Beras and Emma Peaslee. It was produced by Emma Peaslee with help from Sam Yellowhorse Kesler and James Sneed. It was edited by Marianne McCune and fact-checked by Charlotte Isidore. It was engineered by Jimmy Keeley with help from Cena Loffredo. Alex Goldmark is Planet Money’s executive producer.
Maryland health insurers want to raise premiums an average 13.7% for individual plans in 2027
Maryland health insurers want to raise premiums an average 13.7% for individual ACA plans in 2027
Science Can Fully Explain Consciousness? By 326 Theories…
It’s supposed to be a given that machines or brain organoids might be conscious despite not knowing what that is or how it works — but preborn children can’t be…
Buckingham Palace without the king? Charles reveals plans for landmark's future
Buckingham Palace is having a monumental glow up, but King Charles III and Queen Camilla still don't want to live there.
Morocco jails 29, including politicians and sports figures, in drug trial
Casablanca court delivers landmark verdict in 'Escobar of the Sahara' case: up to 12 years for top figures.
Morgan Stanley on life after selling your business: a roadmap for entrepreneurs
Selling your company can be the financial win of a lifetime — and one of the most disorienting transitions you'll ever face.
Bayer wins in US court, but at what cost to public health?
A landmark US Supreme Court ruling protects Bayer from thousands of lawsuits linked to its Roundup weedkiller. Plaintiffs alleged the German agrochemical giant failed to warn users about potential cancer risks.
Sweden: European Social Rights Committee calls for an end to Sweden’s two-tier healthcare system
Amnesty International welcomes a landmark decision by the European Committee of Social Rights finding that Sweden breached the right to health without discrimination.
Poll shows Donald Trump underwater in home state of Florida heading into Midterms
Could that spell trouble for Ashley Moody as she faces Alex Vindman?
Remembering Victory Stadium: How Roanoke’s lost landmark changed sports and civil rights
It’s been 20 years since Victory Stadium was demolished, but the memories and legacy remain alive in Roanoke.
How an Iowa junior college became a sports giant
DMACC athletic programs are quietly dominating through coaching and player performance
Lucky the Bull Gets a Transformation
A local artist has been working for weeks on restoring a historic landmark that will soon be making a public appearance.
Scientists develop predictive roadmap to boost performance in next-gen spintronics
Chiral 2D metal halide perovskites (MHPs) are among the most promising materials for future technologies that exploit the spin of electrons in spin-based optoelectronics, or spintronics, but getting them ...
Making Our Own Luck
We are cross-posting a piece that former NIH official Kris Willis wrote for Macroscience. Kris is now the President and Founder of the Woodley Park Institute, for which I’m a board member. Picking winners or hedging bets? Federal science agencies have long wrestled with the question of how to ensure their billions of dollars of grants and contracts result in maximum benefits for Americans. On the surface, it might seem that a goal-oriented, interventionist style of management would be the best policy: prioritize our most pressing problems and distribute funding accordingly.This top-down strategy creates a unique hazard, though: bad choices can send resources in the wrong direction, resulting in slow progress that impedes the delivery of tangible benefits to citizens. Moreover, if decision makers pursue an applied advance when the underlying scientific principles remain poorly understood, they risk costly failures and a loss of support for the research enterprise at large. Examples include Nixon’s 1971 War on Cancer, undertaken on the premise that a cure could be achieved in less than a decade, the drive to build an operational commercial fusion plant by the mid-1990s, and the National Plan to Address Alzheimer’s Disease, which failed to produce the effective treatments and prevention strategies promised by 2025. The contrasting laissez-faire approach is to hedge your bets. If the path to an advance is impossible to predict, then the wisest choice might be to distribute funding to as widely as possible. The main risk of this strategy is that spreading funding thinly may limit the resources available to the most promising research, resulting in the same negative outcomes as the interventionist approach: limited support for the most promising topics, slow progress, and delayed returns. In reality, at science agencies like the National Science Foundation and National Institutes of Health, program managers navigate between these two extremes, setting some funds aside to target high-priority areas and using the rest to cover the widest possible range of meritorious proposals. This middle path seems like the most rational way to proceed, but it still requires making choices. How much should be set aside for high priority topics? What should those topics be? How should we define merit? Expert opinion can provide a helpful guide, but leading experts can have remarkably different opinions about what matters and what should be prioritized. Moreover, experts and administrators alike can be risk averse, giving an edge to high-profile, well-established concepts. What’s really needed is a data-driven framework to help guide decision-making, one that doesn’t simply repackage prestige or incumbency. Recognizing breakthroughs years in advance Many breakthroughs fail to attract funding or recognition at the earliest stages of development. Katalin Karikó, for example, spent years struggling to win grants for work on mRNA that would eventually win her and Drew Weissman a Nobel Prize. Similar stories can be told about Jim Allison’s groundbreaking studies leading to the development of cancer immunotherapy, Stan Pruisner’s demonstration that prions can self-replicate without DNA, or Robin Warren and Barry Marshall’s proof that Helicobacter pylori, not stress, causes ulcers. Yet at some point, the scientific community recognizes and responds to transformative breakthroughs like these. How does that change happen? And what if science funders could identify the areas that are on the cusp of a breakthrough? Those questions led my collaborators and me to study how scientists responded to past breakthroughs. Based on patterns in that data, we developed a means of predicting future breakthroughs, using biomedicine as a proof of concept. It’s worth taking a moment to describe how our approach works. Briefly, our prediction process begins by grouping the 18 million or so peer-reviewed papers in PubMed, the authoritative database of biomedical research, into roughly 50,000 unique topics. A small subset of these topics are so widely acclaimed as breakthroughs that they have been recognized with a major prize like a Nobel or a Lasker Award. We theorized that studying the development of these outliers over time, especially before they gained acclaim, was the key to identifying future instances of them. After defining topics, we chose 21 representative breakthroughs and asked what they looked like before they won prestigious prizes. To answer that question, we re-ran our topic-mapping algorithm repeatedly, winding back the clock one year each time, stringing together the years to follow the progress of each field as it grew and advanced. We found that in each case, the years leading up to a discovery followed a pattern: a burst of papers on a new, rapidly evolving topic, many of which quickly became influential. These characteristics—the percent of papers that are new, the percentage of papers that are brought in from other topics, and the influence of each individual paper—can all be measured separately for any given topic. Together, they act as a predictive signal that is detectable an average of five years before a transformative discovery is made, and up to thirty years before the discovery receives a major prize. Scanning the current research landscape for topics that display this signal allows us to predict what work will likely produce a future breakthrough. Each year we analyzed includes four or five signals, a number that appears to have remained constant across a twenty year time frame. In their classic work on the sociology of science, Bruno Latour and Steve Woolgar established that the desire to participate in a major discovery is an important motivator for scientists as they consider whether they should take up (or abandon) a research problem. Although further work is needed, the simplest explanation for our results is that this behavior is widespread enough to detect at scale. A foundational advance, or something like it, draws the attention of scientists and causes them to change the direction of their research. They vote with their feet, staking their own reputation and careers by publishing on and citing the new idea. That upswell of interest is the foundation of our breakthrough signal. What kind of research does our model identify as a breakthrough? After building a model based on the patterns in our 21 preselected breakthroughs, we tested it by identifying all early signals of discovery from 1994 through 1997. Of the 18 signals we found in that time period, 17 can be traced forward in time to a breakthrough. Examples include super-resolution fluorescence microscopy (see the image above), the directed evolution of proteins and enzymes (Chemistry Nobel, 2018), and sequencing the human genome (National Medal of Science, 2008). The discovery of the role of leptin signaling in obesity is a particularly interesting case study. Around 1950, scientists noticed the existence of a type of lab mouse that suffered from a unique inherited form of obesity. When given the freedom to choose their own diet, these mice ate more than normal and preferred food that was high in fat. Researchers had few clues as to why the animals overate; early experiments pointed to the existence of a soluble ob factor found circulating in the bloodstream that regulated appetite, but its identity was unknown. In 1994, Jeffrey Friedman and colleagues identified and sequenced the ob gene, noting that the protein it encoded appeared to fit the profile of a circulating factor. A year later, a trio of high-profile publications demonstrated that ob was a hormone that regulated body weight and fat deposition by regulating appetite. One of these was co-authored by Friedman, who christened it leptin from the ancient Greek word for thin. Using our model, the data from 1996 make it clear this advance would become a breakthrough. Scientists had flocked to study the biology of the new hormone, generating the flurry of new papers and citations required to produce a signal. One of these demonstrated that serum leptin concentrations reflected the amount of adipose tissue in the human body, providing clinical validation of the earlier mouse studies. Before the identification of leptin, scientists were unable to point to a specific molecule that controlled appetite and adiposity, so that it was impossible to rule out non-physiological causes of obesity; its characterization fundamentally changed our concept of weight gain. In 2010, Friedman and fellow pioneer Douglas Coleman were awarded a Lasker for the discovery. Our work also identifies breakthroughs in clinical practice and behavioral and social sciences, even though these areas are less likely to draw the attention of major prize committees. One example that falls into this category is the introduction of endovascular aneurysm repair, a minimally invasive surgical procedure for the treatment of abdominal aortic aneurysm, a leading cause of death among Americans over the age of 65. Relative to the previous standard of care, it reduces in-hospital mortality by almost four-fold. In 2017, Timothy Chuter received the American College of Surgeons’ prestigious Jacobsen Innovation award for his multiple refinements to the technique. Another under-recognized breakthrough identified by our model is the development of standardized survey instruments to assess the quality of life for HIV+ patients. The antiretroviral cocktails introduced in the mid-1990s reduced AIDS mortality, but treatment came with serious side effects. The new evaluations showed that patients whose disease progressed had worse physical functioning than Americans with other chronic diseases, while those who were asymptomatic maintained a health-related quality of life on par with the overall US population. This evidence made it possible for patients and activists to argue that even in the absence of a total cure, and in spite of the side effects, alleviation of symptoms was a worthwhile priority for clinicians. My colleagues and I have failed to identify any significant recognition for the physicians and health policy experts who pioneered this advance, although in 2016, researchers called for the World Health Organization to set targets for good health-related quality of life as part of its framework to end the AIDS pandemic. From forecasting to funding How should science funders use our predictions? Any serious discussion of what we should do with this new capability needs to begin with an understanding of its limitations. We can’t (and shouldn’t) invest all of our resources in the small number of topics predicted to produce breakthroughs. Innovative new fields are born from existing ones; they rarely arise de novo. If funders don’t maintain a diverse portfolio, the breakthroughs of tomorrow will have no antecedents. Think of this as eating the seed corn, or killing the goose that lays the golden egg. There are also multiple goals of funding beyond basic scientific discovery, including translating discoveries into clinical practice, developing new technologies, supporting economic development, and training new scientists. The investments needed to accomplish these goals are likely different from those required to support emerging breakthroughs. Finally, we must be aware that we may not capture every instance of a breakthrough. The concept is fuzzy, and not every significant discovery is recognized with a major award. Further, breakthroughs are rare, meaning that our dataset is, by necessity, small. This makes formal estimates of accuracy challenging. Although our overall success rate appears to be high, any one signal may turn out to be a false positive. We found one apparent example: the development of the third generation COX-2 inhibitors, Vioxx and Celebrex, which were much celebrated in the early 2000s as effective but non-addictive pain relievers, meets all the algorithmic criteria of a breakthrough. Five years after it received FDA approval, researchers demonstrated that Vioxx was associated with serious cardiovascular complications, and the manufacturer voluntarily pulled the drug from the market. Celebrex remains available, although like other NSAIDs, it carries an FDA warning for increased cardiovascular risk. Decision makers who were overly focused on the breakthrough potential of this research might have wasted substantial resources nurturing an area that ultimately proved to be a failure—but so would those who relied on expert opinion at the time. That said, the potential benefits of funding the next mRNA vaccine or cancer immunotherapy years earlier than we might have are large. When we can’t assume the outcome of an action, it’s worth conducting an experiment. Can targeted support for areas that are poised to produce a breakthrough increase the return on scientific investment without cannibalizing future advances? With the necessary administrative infrastructure in place, conducting this experiment would be straightforward. First, identify all the breakthrough signals between 2018 and 2023, select half at random, and commit to a decade of investment. For biomedicine, a six year window should yield about 30 topics with the potential to produce a breakthrough. Providing strong support to half of these might be accomplished for $300 million a year. That’s roughly half of the recent annual budget of the NIH Common Fund or around 20% of the fiscal year 2025 budget for ARPA-H. After five years, then again at ten, compare to see which group — the one that was actively managed, or the control — produced more breakthroughs, and on what timescale. Although we used biomedicine as an example, the same experiment could just as well be run for physics, materials science, or any other discipline. Any attempt to undertake such an experiment should keep three points top of mind. First, we can predict the topic of future breakthroughs, but the people and vision for how to move the work forward are still important. In practice, this means success requires active program managers with the expertise to develop the science and the authority to do so, including by recruiting investigators. Second, we would be wise to learn from the failures of past attempts to fund transformative research. High among these are funding modestly repackaged work, confusing the genuinely novel with the merely unfamiliar, and relying too much on incumbent investigators. All of these risks can be mitigated by thoroughly and intelligently integrating high quality data into portfolio management. Finally, we need to have patience. Even with strong funding support, producing a breakthrough takes time. If supporting breakthroughs is the best way to nurture the birth of new fields, we also need to accurately describe and properly manage the other two stages, so that we invest wisely throughout the productive lifetime of ideas and divest once they reach the point of diminishing returns. We would benefit from more study of all of these phases, especially the transition from one to another. More research could answer questions like: When does a breakthrough become an established field? How do the availability of funding, the size and characteristics of the available workforce, and the accumulation of evidence that disagrees with prevailing models affect a field’s decline? Exactly how do old ideas give birth to new ones, and can we speed up the process? The more we understand about the dynamics of scientific progress, the better we can maximize the odds that our curiosity leads to results. I’d call that finding a way to make our own luck.
Graham Platner backs legal maneuver using Maine law to rein in political spending
Democratic U.S. Senate nominee Graham Platner wants to overturn the landmark U.S. Supreme Court ruling that enabled corporations and other outside groups to spend unlimited money on elections by any means possible. He supports a constitutional amendment and ethics rules on the high court, which the Sullivan oyster farmer included in his latest policy rollout […]
Six Female Student-Athletes Named to College Sports Communicators At Large Academic All-District Team
Springfield, Mass. – June 23, 2026 – Six Springfield College student-athletes were named to the 2026 College Sports Communicators (CSC) Academic All-District Team this year.
A season of festivals, special events and America 250 celebrations
The Florida Keys is turning up the heat with summer events this season running from Key Largo to Key West. Think local traditions, world-class culinary festivals, and landmark America 250
Winners and losers emerge after socialist earthquake rocks NYC primaries
Mayor Zohran Mamdani's socialist slate swept NYC Democratic primaries, defeating incumbents like Reps. Espaillat and Goldman in a major shift.
Trump refuses to sign landmark housing bill, demanding Congress pass voter ID law
Trump demanded that Congress pass the SAVE America Act, the proof-of-citizenship voting bill, before he would consider the housing legislation.
Trump suddenly refuses to sign landmark housing bill, citing his stalled elections legislation
Clean sweep for Mamdani-backed candidates in New York's Democratic primary
Brad Lander unseats Dan Goldman in a race that laid bare the city's divisions over the Israel-Gaza war.
Editorial | Brooklyn coffee shop’s snub of Congress member shows politics boiling over in NYC
He was out on Sunday campaigning in Brooklyn for re-election to his Congressional seat when he paid a visit to Poetica Coffee. Goldman said the staff politely
House gives final approval to landmark housing bill aimed at lowering costs
The legislation represents one of the most sweeping efforts in decades to increase the supply of housing and bring down prices.
Abortion rights fight underscores key themes in Maine’s U.S. Senate race
Four years ago today, the U.S. Supreme Court overturned Roe vs. Wade. In the majority of that decision was Justice Brett Kavanaugh, who Republican U.S. Sen. Susan Collins of Maine had voted to confirm after he had told her the landmark decision was “settled law.”
Goldman loses House seat after NY-10 Democratic primary defeat to Lander
NBC News projects that Lander, a progressive backed by Mayor Zohran Mamdani, won the Democratic nomination in the 10th District.
Landmark housing bill advances in Congress with bipartisan support
Measures to provide federal funding for housing production in big cities could be particularly significant to California.
5 vulnerable incumbents to watch in tonight’s primaries: From the Politics Desk
Plus, the DOJ’s voter fraud struggles and a Elon Musk-related controversy in Michigan.
Brooklyn coffee shop that targeted Jewish congressman faces DOJ probe after reported tax, health code issues
Poetica Coffee owner Parviz Mukhamadkulov donated to scandal-plagued candidate Graham Platner and reportedly faces tax debts and health code violations.
Detroit releases report with plans to tackle community health issues
Mayor Mary Sheffield and the Detroit Health Department released a comprehensive roadmap to tackle top health concerns identified by residents by 2028.
Sporticast: Why Netflix, EA Have Their Own World Cup Games
On the 563rd Sporticast episode, hosts Jacob Feldman and Justin Birnbaum discuss some of the biggest sports business stories of the week, including a detailed breakdown of Netflix’s FIFA World Cup video game. Following Electronic Arts and FIFA’s split in 2022, both parties now have World Cup-related offerings on the market. Electronic Arts recently launched …
Goldman Sachs analysts say EV adoption set to hammer demand for oil
Goldman Sachs says a shift spurred by the Iran War and its disruption to energy markets will put downward pressure on crude prices through 2027.
Rep. Dan Goldman addresses Brooklyn coffee shop banning him over his views on Israel
Rep. Dan Goldman called it “sad” that a Brooklyn coffee shop apparently banned him with a viral social media post amid a heated Democratic primary election that has focused heavily on the politics of the Israel-Gaza war.
Senate passes landmark housing affordability bill after bipartisan breakthrough
The Senate passed a bill aimed at lowering housing costs on Monday after a major breakthrough and rare bipartisan consensus.
NYC coffee shop bans pro-Israel politician in hostile social post: 'we don’t serve... genocide enablers'
A Brooklyn coffee shop criticized Rep. Dan Goldman after he bought coffee there, saying it would have turned him away as a "genocide enabler."
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World Cup Hits Half Time Kansas City’s contribution to the World Cup reaches its halfway point this week. Thursday's Netherlands-Tunisia match is Game 3 of six at Kansas City Stadium, making it a natural time for a progress report: How are we doing? First up: Have we solved the traffic headaches around the stadium? The
RedMagic shows its next gaming tablet with water cooling, reveals its launch date
It's finally coming this month. Back in May, RedMagic announced that it would be unveiling its next gaming tablet in June, and today we finally have an...
Old Dominion University Women’s Business Center Helps Suffolk Company Earn National SBA Award
When Rachael and Joseph Culbertson started Culbertson Contracting in 2021, the couple knew they had the work ethic to succeed; they just needed the right roadmap. Now, thanks to a transformative partnership with Old Dominion University through its Women’s Business Center, the Suffolk-based company has been named Virginia’s Blue-Collar Small Business of the Year by the U.S. Small Business Administration (SBA).
Savannah Guthrie praises husband Mike Feldman in rare Father's Day post
"Today" show host Savannah Guthrie shone the Father's Day love light on her husband Mike Feldman, calling her supportive spouse of 12 years the family's "hero."