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Board Approves Horvath Motion to Evaluate Warner Bros Acquisition and Protect LA Entertainment Jobs - Supervisor Lindsey P. Horvath
Today, the Board approved a motion to analyze the potential economic impacts of the proposed Paramount-Warner Bros. merger and advance efforts to protect the region’s entertainment workforce.
How easing regulations on heavy metals air pollution could impact health | Harvard T.H. Chan School of Public Health
A recent repeal of federal environmental regulations aimed at limiting the emission of mercury and other heavy metals from power plants could have serious health impacts, according to Harvard Chan School experts.
Paranovus sells 14.3M shares at 35 cents to raise $5M
A single institutional investor agreed to buy the shares, with closing set for about March 25. Paranovus says net proceeds will fund working capital.
Santa Cruz County business filings: Week of March 24
Businesses operating in Santa Cruz County must register with the county clerk. Lookout Santa Cruz reviews the public filings from local businesses to report on new businesses starting in the area.
Newsom says he regrets earlier comments likening Israel to an ‘apartheid state’
California Gov. Gavin Newsom said that he regretted using the word “apartheid” to describe the Israeli government’s treatment of Palestinians, though he warned “that’s a word you may hear others use” if Prime Minister Benjamin Netanyahu pushes for territorial gains.
Delta suspends VIP services for Congress members amid DHS shutdown, TSA delays
Delta suspended VIP congressional services amid the government shutdown, telling lawmakers they'll be treated like regular travelers by SkyMiles status.
Health alert issued for ground beef sold in 5 states and DC
Federal regulators are asking consumers in five states and the District of Columbia to check their freezers for possibly contaminated ground beef.
A rare active volcano on Mars may be causing the whole planet to spin faster
Data from NASA's InSight mission suggests the Red Planet's Tharsis region is more active than previously thought and may be why Mars is spinning more quickly over time.
A $25 minimum wage in D.C. could shift business to N. Va., restaurant association says
A $25 minimum wage proposal in D.C. could push some restaurant workers into Northern Virginia in the short term and, in the long term, potentially drive businesses to relocate as well, the head of the region's restaurant association says. The Restaurant Association Metropolitan Washington -- an outspoken opponent of D.C.'s Initiative 82, which sought to phase
Meet the 2026 Influential Women in Business and see the Women’s Leadership Symposium lineup
They run hospitals, build companies, fight cancer and welcome visitors to the Capital Region. Now, nine of the area’s most accomplished women are being recognized as 2026 Influential Women in Business by Baton Rouge Business Report. The honorees will be recognized May 19 at the Influential Women in Business Luncheon, which follows the fourth annual […]
Inaugural festival to serve up community science activities
The inaugural Wilmington Community Science Fest scheduled for Saturday brings the wide array of community science activities offered in the region.
Lessons from China—Questrom Class Took BU Students on Memorable Business Trip
Over spring break, 25 Boston University students joined Professor, Greg Stoller to see what Chinese companies could teach them
Registration opens for hands-on ocean science program for teachers this summer
Registration has officially opened for BLOOM Educators, Bigelow Laboratory for Ocean Sciences' professional development program offering hands-on training for middle and high school teachers.
4 Pitt people were named Pittsburgh Business Times 2026 Women of Influence
The awards recognize the region’s businesswomen, including one Pitt dean and three alumnae, who make impactful change by leading organizations.
A Veteran Group Jumps In for a Democrat in Iowa Senate Race.
VoteVets is the first super PAC to intervene in the race for Josh Turek, a state legislator who was born with spina bifida after his father was exposed to Agent Orange in Vietnam.
Got a burning sports question? Ask The Athletic’s daily newsletter
Send The Pulse your most pressing sports questions, and we'll regularly share answers from our experts.
Neal Stephenson, who coined the term ‘metaverse’, says head-mounted VR hardware will never happen
: ‘People don’t like wearing things on their faces and don’t trust those who do’
We disagreed on politics. We agreed on wine. That was enough.
At the Virginia Governor’s Cup Gala in Richmond earlier this month, a very dapper gentleman approached me and introduced himself. In his light-colored suit and bowtie, he looked very Southern in a classical sense, the sort of Virginia Gentleman you used to see south of the Rappahannock as recently as my college days. “I’m a longtime reader and fan of your writing, if not your politics,” he said. His comment was the proverbial iron fist in a velvet glove, simultaneously conveying praise and disapproval while establishing boundaries. Man, I wish we still discoursed like this instead of shouting bromides and insults to try and “own” our opponents with a funny meme and a furrowed brow. Subscribe “Well, we’ll always have wine to share together,” I said, and thanked him for his kind words. We clinked glasses, exchanged pleasantries about the delicious gold medal-winning wines being poured that evening, and went our separate ways. Our exchange reminded me that more unites us than divides us. Wine brings people together to share a meal and a few hours of joy despite our differences.1 That’s why I refer to the wine community — including readers and consumers — rather than the wine industry. Together, we are so much more than production, distribution and sales statistics. A few minutes later the evening’s awards ceremony began. Applause grew as the 12 winemakers who made the top-scoring wines for the Governor’s Case took the stage, including a loud cheer for Jonathan Wheeler of Trump Winery and his 2018 Blanc de Noir sparkling wine. All the winemakers on stage had reason to be proud, Wheeler perhaps more so. Trump Winery was the only winery to win six gold medals in the competition this year. (Wineries are limited to six entries.) Two of Wheeler’s ciders also won gold medals in a separate competition. When you cover the labels and take the sour taste of politics off your palate, the wines are pretty darn good.2 Then Gov. Abigail Spanberger, newly elected Democrat and Virginia’s first female governor, was introduced to great applause to announce which of the 12 wines had won the Governor’s Cup. She spoke for a few minutes about the importance of wine to Virginia’s economy and tourism and the international acclaim Virginia wine has received. Just two weeks earlier, she gave the Democrats’ response to Trump’s State of the Union speech, but this night wasn’t about politics. That didn’t stop several people in the crowd from speculating on the irony should she have to present the trophy to Trump Winery. In the end, Valley Road Vineyards was displayed on the screen behind Spanberger as the winning winery. Blue Bee Cidery in Richmond took top honors for that category. The crowd cheered a female governor presenting the state’s highest trophy to a female winemaker and then resumed the evening’s festivities, united by their mutual love of wine. A whiff of politics couldn’t dim the cheer of celebration and a community united by its love of wine. In Memoriam: Michel Rolland The global wine community lost a giant March 20, with the passing of Michel Rolland. He was 78. Rolland was the original “flying winemaker,” a globe-trotting consultant who helped Bordeaux regain its mojo in the 1970s and then shaped the rise of Napa Valley cult Cabernet as consultant to Simi, Harlan, Newton, Screaming Eagle, Araujo, Dalle Valle and other wineries. He was instrumental in Argentina’s rise to prominence and even had his own winery, Clos de los Siete, in a partnership with other wine families. Rolland’s career arc paralleled that of Robert Parker, the world’s most influential critic. Parker championed many of the wines Rolland consulted on, helping build his reputation and demand for his services. It also made him a target for Parker’s critics. As W. Blake Gray wrote on Wine-Searcher in his excellent tribute to Rolland: Rolland created the type of wines Parker loved: rich body, plenty of fruit, soft tannins. He sometimes faced the accusation of creating a generic international style of red wine, where the great wines he made in Argentina were indistinguishable from the great wines he made in France. Rolland chafed at that critique, as did many of his fans. He was credited with championing green harvesting and leaf pulling, as well as careful selection of grapes in the winery, practices we nearly universally think of today for high-quality winemaking. “Michel was an incredible innovator who changed how wine was made and how grapes were grown,” Napa Valley winemaker Aaron Pott wrote on Facebook. “His work has transformed the wine trade. He created new ways of looking at wine, tasting wine, evaluating ripeness and quality. … This was not just a man with a ‘style’ that he imposed on vineyards but a man that understood how to make great wine from great sites.” Rolland started his consulting company in 1973 in Libourne, in Bordeaux, with his wife, Dany. Both had graduated the year before from Bordeaux’s Institute d’Oenologie. The couple sold their majority share in the business in 2020, according to Wine Spectator. Over his career, Rolland reportedly worked with more than 100 wineries in 20 countries. He even made it to Virginia, where he consulted for Kluge Estate in the mid-2000s. (Kluge Estate is now Trump Winery.) Reader feedback, please! Last week, I did my first WineLine Live! with Dr. Laura Catena of Catena Zapata winery in Argentina. We enjoyed a fascinating discussion about her efforts to preserve the genetic heritage of old vineyards in Mendoza. I conceived of WineLine Live! for paid subscribers, as a thank you for your financial support. And while only a few people joined live, the video now has more views than I have paid subscribers, so I guess that’s pretty good. Even so, I’m considering opening future installments to anyone on Substack to reach a broader audience. So my questions to you: Should these be public? And what format do you prefer? Live gives a chat feature with the potential for viewers to interact with me and the guest, while a video post would just be that. Another alternative is a podcast, which would just be audio, without video of my chins. Please let me know in the comments. Leave a comment In the Glass A few wines I’ve enjoyed recently: Bonny Doon Vineyard Take Me to Your Liter, Le Cigare Volant, Red Wine of the Earth. 2023, Central Coast, CA. Blend of Grenache, Syrah Cinsaut and Petite Sirah. Delightful wine with expressive red fruit flavors, casual drinking. Doon lovers of a certain age will remember Randall Grahm’s Big House Red; this is more in that style than his original Le Cigare Volant, modeled after Chateauneuf du Pape. The liter bottle makes it an even better value. I see this online at about $15. Great value. Albert Bichot Bourgogne Pinot Noir Origines 2023. 13% - Textbook pinot noir and an excellent, affordable entry (regional) Burgundy. Wine Enthusiast Top 100 Wines of 2025. $24 at Total Wine & More. Loma Larga Pinot Noir 2021 “Coastal Cool Climate Wine”, Valle de Casablanca, Chile. An older sample, showing beautifully. Spicy and fruit forward. I’m seeing widely varied pricing online, from $18-$32. At the lower end, it’s a terrific value. 13.5% Dr. Loosen Riesling Dry 2016, Mosel, Germany. Found this “in the stack.” And it stacked up well, shedding some of its youthful acidity for opulent Riesling character, including a hint of the mineral oil older Riesling often features. A great value, as I’m seeing it as low as $14 online. 12% abv. Red Tail Ridge Blau Franc Blend 2024, Sans Oak, Finger Lakes. 13.4% abv. The name is a neat portmanteau of Blaufrankisch and Cabernet Franc, thus Blau Franc. The blend is 50-50, no oak involved. The Blau dominates on the palate, with the spicy caraway seed (think New York deli rye bread). The Franc adds body. The result is juicy, energetic and joyful. Sokol Blosser Estate Rosé of Pinot Noir 2025, Dundee Hills, Willamette Valley, Oregon. This first rosé of 2025 was a welcome respite to our cold, snowy winter here in the Mid-Atlantic. Oh man, I needed this! Bright and energetic, exuberant even, it perks up the mood and goes down fast. 13%. Certified B Corp. Ingredient and nutrition labeling, and in a modest way that doesn’t occupy a lot of label space. (Since it’s not required, presumably there are no minimum font size requirements.) More wineries should follow this example. Dave McIntyre's WineLine is a reader-supported publication. To receive new posts and support my work, consider becoming a free or paid subscriber. Subscribe Thanks for reading Dave McIntyre's WineLine! This post is public so feel free to share it. Share 1 Some restraint may be required. 2 Especially the bubblies.
An ode to Olympic sports
Under the current cash-grabbing model, universities are harmfully disregarding the fundamental purpose of collegiate athletics.
Former Brazilian leader Bolsonaro's health improves and he could serve sentence under house arrest
One of his doctors says former Brazilian President Jair Bolsonaro has been transferred to a regular hospital room in the capital of Brasilia as he continues to recover from pneumonia
Can pesticide exposure before pregnancy affect babies’ health?
A study co-authored by UCLA researchers suggests certain chemical compounds correlated with lower newborn health scores.
Dems hope for long-shot upset in SD 14 Special Election between Josie Tomkow, Brian Nathan
Early voting, voter registration and fundraising data suggests Nathan will come up short, but there could be a silver lining for Democrats.
Two bills with the potential to increase healthcare competition in Tennessee make headway
Two bills making their way through the Tennessee General Assembly have the potential of shifting the healthcare landscape of our region.
Two bills with the potential to increase healthcare competition in region make headway
Two bills making their way through the Tennessee General Assembly have the potential of shifting the healthcare landscape of our region.
UCI Health lays off 150 workers as part of restructuring
UCI Health said the cuts were prompted by a changing environment that includes shifts in federal funding, reimbursement pressures and rising operational costs,
Knicks go for 7th straight win, face improved Pelicans
The New York Knicks are surging as the NBA regular season enters its final three weeks.
Oura Ring 5 leak reveals design tweaks and Deep Rose finish
The Oura Ring 5 has surfaced in a leak showing design tweaks and colour options. An FCC registration hints the device may launch in 2026.
AI attack ads are hitting Massachusetts political campaigns
Lawmakers are considering new legislation to regulate the use of AI in political advertising. Have you spotted them?
F1 CEO talks US growth as business accelerates
Formula One (F1) CEO Stefano Domenicali joins Yahoo Finance Executive Editor Brian Sozzi to discuss F1's rapid growth in the US market, new racing regulations, and more. Watch the video above to hear more on the sport's focus on expansion and entertainment.
Peregrine Road performs at the Jesup
BAR HARBOR — On Thursday, April 9, at 5:30 p.m., the Jesup will host a free Music and Conversation program with Peregrine Road (Rachel Bell and Karen Axelrod). Peregrine Road
Nominate a Capital Region health care executive who’s making a difference
Who’s running the organizations shaping health care in the Capital Region — and doing it well? That’s the question at the heart of the Outstanding Health Care Executive category in Business Report‘s inaugural Excellence in Health Care Awards. This recognition is for the senior leaders who are making the hard calls, building strong teams and […]
Register for 25Live trainings at Health Sciences Center
The Facilities Planning and Scheduling team will provide a 25Live training session from 2-3 p.m. April 8 at the Health Sciences Center, Room 2912.
Benjamin Logan students shine at Regional Science Day competition
Benjamin Logan students had a strong showing at the Ohio Academy of Science Regional Science Day at Ohio Northern University. Competing against top students from […]
Cardinal Health Appoints Patricia A. Hemingway Hall as Board Chair
/PRNewswire/ -- Cardinal Health (NYSE: CAH) today announced that its Board of Directors has appointed Patricia A. Hemingway Hall to succeed Gregory B. Kenny as...
Women’s health innovation is a huge opportunity Philadelphia is in danger of missing
A booming medical market is creating jobs, research and startup funding, and the region has the talent and institutions to become a national leader, a local entrepreneur writes.
Ambani's Reliance Jio: businesses and investors of the IPO-bound firm
Indian billionaire Mukesh Ambani's Reliance Jio Platforms is gearing up to file papers seeking regulatory approvals for a Mumbai listing, in what is likely to be the biggest-ever stock offering in the country.
Exclusive | Lawmakers to Introduce Bipartisan Bill Banning Sports Bets on Prediction Markets
A bipartisan pair of U.S. senators are introducing legislation to prohibit CFTC-regulated entities from listing contracts related to sporting events.
Scouting Michigan State basketball Sweet 16 matchup with UConn
Get a first glimpse at the NCAA Tournament East region Sweet 16 semifinal matchup between 3-seed Michigan State basketball and 2-seed UConn.
Personnel note: Tampa Electric names Ed Narain as Director of Regional Affairs
'Tampa Electric has a long history of supporting the growth and success of the communities it serves, and I look forward to helping strengthen those partnerships.'
CBS Sports and TNT Sports Announce Tip Times and Commentator Teams for Regional Semifinals on Thursday, March 26, and Friday, March 27
Microsoft: Removing some Copilots will improve Windows 11
: 'Doze boss admits OS needs smaller memory footprint, fixes for old issues like bad Bluetooth, more prominent WSL
Commentary: Keep Kentucky judges judging and leave politics to politicians
A provision in House Bill 534 would invite judicial candidates to disclose their political party affiliation and their current and past voter registration, including “communicating political values or viewpoints consistent with his or her party affiliation.”
B.C. recruits 400 healthcare workers, most from Washington and Oregon
A successful targeted campaign recruited more than 400 U.S.-trained healthcare professionals to British Columbia, many of whom are from Oregon and Washington.
Samsung Brings AirDrop Support to Quick Share with Galaxy S26 Series
Samsung is introducing AirDrop support to the Galaxy S26 series, making it easier for users to share content between devices using Quick Share. The feature will begin rolling out from March 231, starting in Korea and expanding to more regions including Europe, Hong Kong, Japan, Latin America, North America, Southeast Asia, and Taiwan. AirDrop support […]
Why Have Patriots Not Done More To Address Pass Rush?
The New England Patriots had just 35 sacks last season, ranking near the bottom of the league in the regular season.
Your Thymus and Your Healthspan
Our thymus gland plays a central role in the development or our immune system, specifically for supporting T cell development (how these cells got their name, maturation and differentiation in the thymus) and discriminating between self and foreign, non-self antigen proteins with production of dendritic cells. As we age, our thymus gland shrinks—the process known as involution—with progressive change from spongy to fatty tissue, with loss of functionality. But this process, with respect to timeline and extent, markedly varies from one person to the next. And to make things even more complicated, our thymus gland anatomy and precise location in the chest also is highly variable. So the famous Frank Netter diagrams from the 1960s (such as at left below) don’t capture the remarkable heterogeneity that a random set of 12 chest CT scans (below at right). What I consider as 2 landmark papers in Nature this week (here and here) used AI to quantify health of the thymus in 2 large cohorts, and then correlate the metric to a broad array of health outcomes. In this edition of Ground Truths, I’m going to cover three questions: (1) How was thymus health determined by AI?; (2) How is thymus health linked to key clinical outcomes? and (3) Are there ways we can promote a healthy (aka rejuvenate) thymus gland in our later years? Subscribe 1. How was thymus health determined by AI? This was accomplished by extensive work developing and validating an AI pipeline for 2 stages, the first for localization and segmentation of the thymus bed, and the second to quantify a digital marker, termed the thymic health score. There’s a lot to this algorithmic development, so I won’t go into all the details, but just provide a rudimentary outline of what was done. The 1st stage used supervised learning with 2 radiologists reviewing 2,461 chest CT scans. That work trained a 3D U-Net model to automatically identify the thymic bed’s 3D cropped region using center of mass coordinates, which reached 99.8% accuracy. The 2nd stage used a foundation model that was pre-trained with SwAV (which stands for Swapping Assignment between multiple Views), a self-supervised model, that generated a high-dimensional thymus representation of 4,096 features. That compares to the radiology reductionist and subjective scoring of 0 to 3 where 0 means the thymus is fully degenerated and fatty, and 3 is considered dense, intact glandular soft tissue. Notably, the self-supervised learning (SSL) performance was superior to supervised (AUC ~0.75 vs 0.55, respectively) reflecting the shallowness of the 0-3 classifier vs SSL’s holistic, self-taught AI. The thymic health score ranged from 0 to 100, with the highest number indexed to fully preserved thymic health. The algorithmic work extended to explainability with both Shapely value distribution, meaning the model was holistic not relying on any “magic” pixel, and occlusion sensitivity, demonstrating the model’s performance was not affected by ribs, sternum, lung tissue, but rather focused on the thymic bed directly. Below are a few saliency maps from the occlusion sensitivity that indicate the thymic bed focus, not affected by neighboring structures, using the jet color scale. Now the AI was ready for processing ~25,000 CT scans, each over 30 MB files, from the 2 large participant cohorts to provide a thymic health score, it did so in less than 14 hours, which is less than 2 seconds per scan! Share 2. How is thymus health linked to key clinical outcomes? The two cohorts were the National Lung Screening Trial, NLST (N=25,031) and the Framingham Heart Study, FHS (N=2,581) each with baseline demographics and long term follow up of >12 years for health outcomes. From the NSLT, you can see below that increased age and body-mass index were correlated to reduced thymic health. And, overall, men had reduced thymic health scores compared with women. There are a lot of graphs in the paper for outcomes, for both the NLST and FHS cohorts. To simplify the major outcomes, below is a composite Figure with striking reduction of all-cause mortality and for the different causes of death. The results were consistent between the 2 cohorts. For example, the cardiovascular mortality hazard ratio average was 0.57 in NLST and 0.38 in FHS (weighted to be 0.53 for the aggregate). The reduction of mortality also extended to digestive diseases and pulmonary disease (data not shown below). Lung cancer incidence was reduced by 36% for high vs low thymic health (Figure below, with a panel -incidence and b panel-mortality, adjusted for age, sex, BMI, smoking status). Notably, there was a smoker’s paradox: lower incidence and improved survival for lung cancer in smokers who had a high thymus health score. Smoking was associated with lower thymic scores whereas alcohol was not. Higher thymic health was linked to higher HDL cholesterol, lower triglycerides, lower fasting blood glucose, and lower systolic and diastolic blood pressure. Inflammation biomarkers, such as C-reactive protein and interleukin-6, were elevated in the people with lower thymic health scores. In their second paper, the same team looked at the relationship between thymic score and outcomes for 3,476 patients receiving cancer immunotherapy. The non-small cell lung cancer progression-free survival was reduced in patients with low thymic health score. A parallel relationship for survival was seen for other types of cancer including melanoma, breast, and kidney with a 44% lower risk among high thymic scores (Figure). A similar pattern was seen with different immune checkpoint inhibitors. The thymus health score outperformed programmed death ligand-1 (PD-L1)and tumor mutation burden (TMB) assay of the tumor and was an independent prognostic marker of progression-free survival. In this dataset, a direct connect with thymus score and adaptive immune function was noted with a correlation before cancer treatment for both T-cell diversity and thymus T-cell production (a metric known as T cell receptor excision circles). Thymus Removal Study There is a highly relevant citation about thymus function before moving onto ways to rejuvenate it. In 2023, a very important study of thymus removal during cardiothoracic surgery was published, with 1146 patients undergoing thymus removal vs 1146 matched controls (mean age 55 years). The adverse outcomes for thymus removal were striking, with a 2.9 higher risk of all-cause mortality and doubling of cancer incidence, 1.5 fold increase in cancer mortality, and 1.5-fold increase in autoimmune diseases. The immune function showed marked compromise after thymus removal, as reflected by CD4+ and CD8+ T cells (Figure below) Share Ground Truths 3. Are there ways we can promote a healthy (aka rejuvenate) thymus gland in our later years? In recent months we’ve learned a lot about the process of thymus involution and the pathways by which this may be modulated. Thymus involution is primarily due to loss to thymus epithelial cells (TECs) and there are 2 subtypes with different functions: the cortical, responsible for positive selection of T cells, and the medullary, for negative selection. When adipose tissue infiltrates the thymus, thymic adipocytes are pro-inflammatory, knocking out T-cell output. Likewise, systemic inflammation, or “inflammaging,” from smoking, obesity, and chronic stress promote thymic adipocytes. Now, from preclinical studies, we know about key pathways that account for these processes. Historically, back in 2014, FOXN1 was recognized as a single master transcription factor essential for TEC function, with studies in mice with forced FOXN1 upregulation leading to thymus regeneration. That laid the foundation for potential regrowth of quiescent thymus cells. It took awhile to find pathways to accomplish this goal and to even refute its role as the master regulator. The Liver-Thymus Axis Feng Zhang and his team recently showed that injection of an mRNA vaccine to the liver encoding DLL1, IL-7 and FLT3-L in combination, factors known to support thymopoiesis (Figure), successfully enhanced immune function in aged mice. However, the effect was transient. The FGF21 Story Two reports in 2025 addressed the thymus gland’s production of FGF21, a growth factor (fibroblast growth factor 21) and its control of thymus involution. This growth factor is also produced by the liver, but it doesn’t have impact on the thymus in aged rodent models. In contrast, The liver’s hepatocyte growth factor (HGF) has been shown to reverse senescent TEC structural changes. Growth hormone stimulates production of insulin growth factor-1 (IGF-1) in the liver and the thymus. Two small studies in human participants (TRIIM, for Thymus Regeneration, Immunorestoration, and Insulin Mitigation) of 6 and 50 people, respectively, treated with combined human growth hormone, metformin and DHEA, suggested the potential of slowing epigenetic aging and improving thymus mass and function. But the combination of drugs, small sample, and lack of controls make conclusions murky. Increased thymus FGF21 led to increased CD8 T cells in old mice and extended healthspan and improved physical performance. Building on the previous FOXN1 data, ablation of β-klotho, the obligatory co-receptor for FOXN1, accelerated thymic aging. The benefit to FGF21 was confirmed in a companion paper using an FGF21 knock-in mouse model showing thymus enlargement and increased TECs throughout the lifespan. (schematic Figure below). The accompanying editorial for these 2 papers speculated: “The proposed link between age-associated thymus involution and organismal aging is intriguing, and suggests we might seek to achieve systemic rejuvenation by counteracting thymic involution.” Other Factors Lessons from the Axolotl (Mexican Salamander) In an elegant set of experiments of the axolotl (Figure), known for its complete thymus regeneration after total surgical removal, mediators were identified. Surprisingly FOXN1 was dispensable. But midkine, a growth factor, appeared to be the driver, the initiator of thymus cell growth, survival, and repair. Other components that contributed were Postn+ (periostin-expressing mesenchymal niches) and Ccl19, a chemokine protein from the bloodstream. RANK and RANKL RANK (receptor activator of nuclear factor κB its ligand (RANKL) have been considered key regulators of medullary TECs. In a study of both aged mice and human thymus cell cultures, their key role was confirmed, with multiple benefits of resorting TEC function, recruitment of progenitor cells, and T cell development. Subscribe Summing Up This body of work strongly supports the health of the thymus gland as a critical regulator of human healthspan, not just a correlate or link. The new landmark studies are reinforced by the regenerative biology experimental models that have shown, via an array of mediators, that healthspan of aged mice is at least in part dependent on thymus gland function and its critical role for maintaining adaptive immunity. It sure seems that we’d be better off having an immune reservoir of naive T cells instead of a profile in older adults of exhausted, low quality, memory T cells, with a senescent phenotype. It is striking that we ignored the importance of the thymus gland for many decades. A wake-up call was the results of the thymectomy matched control study reviewed here, with the opposite of high thymic health score improved health outcomes. The convergence of AI and healthspan here is notable. The exceptional and laborious work for developing and validating (no less explaining) the AI to quantify thymus health set the foundation for probing the connect the major health outcomes in two cohorts with extensive follow-up. We’ve never had a way to meaningfully quantify the thymus gland before, so this represents important leverage of supervised, self-supervised, and transformer models. The study wouldn’t have been possible without AI. And it begs the question as to whether there are ways we can maintain our thymus at a high health score. But it’s not so simple to rejuvenate our thymus. There are multiple risks including the induction of autoimmunity, increasing the risk of cancer, and inducing a pro-inflammatory state. For example, factors that increase TEC proliferation could compromise the medulllary negative selection process and leak out auto-reactive (self-attacking) T cells. Thymic cells could be induced to proliferate, but we know, for example, that growth hormone and IGF-1 are associated with an increase risk of cancer. If thymus rejuvenation doesn’t clear out the accumulated senescent cells in older adults, then inflammation within the gland could block the production of TECs. Keeping these risks in mind, we now have identified many ways to keep our thymus healthy as we age that undoubtedly will be tested in clinical trials going forward. Ultimately, the benefit-to-risk tradeoffs will be defined. In the meantime, we have desperately needed an immunome. As I’ve stressed in multiple prior Ground Truths, we have no test in the clinic to assess a patient’s immune status! It was very encouraging for me to get an email from Hugo Aerts, the senior author of the landmark papers in the days after they were published: “I also wanted to say that your Substack on “Why We Need an Immunome” was inspiring for this work. We found it a very compelling perspective and greatly enjoyed reading it.” Just having an assessment of a person’s immune status via a chest CT scan, with millions of these performed per year, might help in guiding the right immunotherapy for cancer (e.g. more intensive, combinations for those with low thymic health scores) and help define people who are increased risk for age-related diseases of cancer, cardiovascular, and neurodegenerative. The main theme of Super Agers is that we now have many layers of data (genetics, proteins, biomarkers, organ clocks that can be integrated via multimodal AI) for us to define a person’s specific risk decades before one of these age-related diseases leads to symptoms, enabling prevention. From the new studies this week, we can add thymus health score as yet another way to understand a person’s risk, a window into their adaptive immune system and healthspan. And perhaps someday we will be able to safely rejuvenate the thymus, or maintain its health through one’s life, and use the thymus health score to monitor. NB: I wrote this post (No A.I.) A Quick Poll Loading... ********************************************************************* Thanks to Ground Truths subscribers (now > 200,000) from every US state and 212 countries. Your subscription to these free essays and podcasts makes my work in putting them together worthwhile. Please join! If you found this interesting PLEASE share it! Share Ground Truths Paid subscriptions are voluntary and all proceeds from them go to support Scripps Research. They do allow for posting comments and questions, which I do my best to respond to. Please don’t hesitate to post comments and give me feedback. Let me know topics that you would like to see covered. Leave a comment Many thanks to those who have contributed—they have greatly helped fund our summer internship programs for the past two years. It enabled us to accept and support 47 summer interns in 2025! We aim to accept even more of the several thousand who will apply for summer 2026.
Introducing the 2026 Northeast Arkansas Outstanding Business Awards finalists - Talk Business & Politics
For several weeks, we have been soliciting the region’s business community for nominations for our first recognition program of the year: the Northeast Arkansas Outstanding Business Awards, presented by Arvest...
Oscar-Winning Alumnus Returns to Pasadena’s ArtCenter for Entertainment Design Expo
One week after winning the Academy Award for Best Animated Feature, KPop Demon Hunters co-director Chris Appelhans returns today to ArtCenter College of Design, the Pasadena campus where he studied illustration, for the college’s third annual Entertainment Design Expo. The expo, known as ENTX, opens the Hillside Campus to the public for a full day of gallery exhibitions, game playtesting, animation screenings and interactive experiences featuring work from more than 200 ArtCenter students and alumni. General admission is free with advance registration. Two industry panels — including Appelhans’s talk — require $15 tickets. Appelhans, who graduated from ArtCenter with a bachelor of fine arts in 2002, co-directed KPop Demon Hunters with Maggie Kang. The animated film, produced by Sony Pictures Animation and released on Netflix, became the streaming platform’s most-watched film in history, according to Netflix, and swept awards season with wins at the Golden Globes, the Annie Awards and the Grammys before taking the Oscar on March 15. His talk and audience Q&A is scheduled from noon to 1 p.m. in the Ahmanson Auditorium. Doors open at 11:30 a.m. The film’s ArtCenter ties extend beyond its co-director. Art director Angela Sung, cinematographer Gary H. Lee, visual development artist Celine Kim and painter Simon Baek are all ArtCenter graduates who worked on the production, according to the college. The free portions of ENTX include a concept design showcase, a production design gallery, a model gallery, a stop motion studio preview, an alumni gallery and a KPop Demon Hunters fan art gallery. Visitors can also playtest games designed by ArtCenter students. An Animation Shorts Showcase runs from 2 to 3 p.m. and includes “Boy, I’m Scared,” a capstone short by ArtCenter graduate Lindsey Tenaglia that was named a semifinalist for the 2025 Student Academy Awards in the animation category. Also screening
Scientists discover surprising brain trigger behind high blood pressure
Scientists have uncovered a surprising brain-based trigger for high blood pressure, tracing it to a small region in the brainstem that normally controls breathing. This area, which kicks in during forceful exhalations like coughing, laughing, or exercise, also appears to activate nerves that tighten blood vessels—raising blood pressure. When researchers switched off this region in experiments, blood pressure dropped back to normal, suggesting it plays a direct role in hypertension.
Golden Knights intent on igniting sluggish offense vs. Stars
With 12 games left in the regular season, it's fair to say that things are trending in the wrong direction for the Vegas Golden Knights.
Dynamax Regice Max Monday: Event Guide
Max Monday features a different Pokémon in power spots for the whole day. Regice Max Monday takes place on March 23rd, 2026. This Max Monday is the fourth March Pokémon, and it is the debut of the legendary Ice Pokémon Dynamax Regice! Dynamax Regice is a Tier 5 Max Battle in Pokémon GO. It will cost […]
AI-generated ads are trickling into political campaigns, sparking big worries
AI usage in political ads is largely regulated at the state level, but there remain concerns about how they can mislead voters.
Outgoing MSPs leave Holyrood with relief, regret and unfinished business
A record 42 MSPs are stepping down, from grandees to first timers - they share their reasons why.
Arizona softball walks off ASU to even series
Arizona softball earned a walk-off win over ASU Saturday night, though not the kind the Wildcats may have been expecting through the first part of the game. Arizona jumped out to an 8-0 lead, then allowed the Sun Devils to claw all the way back before Regan Shockey delivered a walk-off single in the seventh […]
Coaches in elite company clash when Kansas faces St. John's
SAN DIEGO -- Only three active head coaches in Division I college basketball have won multiple national championships. Two of them meet for a berth in the Sweet 16 when Bill Self's No. 4 Kansas Jayhawks face Rick Pitino's No. 5 St. John's Red Storm on Sunday in the second round of the NCAA Tournament East Region.
Utica University Science Fair Inspires Young Scientists
Young scientists from local middle and high schools gathered for the 47th annual Utica University Regional Science Fair.
Brooks Nader, 29, Reveals She Had Liposuction ‘Years Ago’ and Regrets It: ‘I Just Didn’t Need It’ (Exclusive)
The model and reality star tells PEOPLE that she experienced unwanted side effects from the procedure
LeBron James breaks record for most NBA games played
LeBron James broke the NBA record for most regular-season games played on Saturday, taking the court for his 1,612th when the Los Angeles Lakers tipped off against the Orlando Magic.James, playing his unprecedented 23rd season, already holds a host of NBA records, including points scored, field goals made and field goals attempted and the longest streak of regular-season games with at least 10 points scored -- 1,297 -- in history.
Sanford Sports launches in Black Hills region
Sanford Sports is expanding into the Black Hills, bringing its research-backed training programs and services to athletes across the region.
Fact-checking Senate Minority Leader Chuck Schumer on the effects of the SAVE America Act
Senate Democratic Leader Chuck Schumer said the SAVE America Act would require in-person voter registration, “something only 5% of Americans do today." The act would require that, but the rate of in-person registrations is higher than Schumer said.
Politics Unplugged (Full Episode) March 22, 2026
This week on Politics Unplugged, Progressive activist Kai Newkirk explains why he is running to unseat Democratic incumbent Greg Stanton in the congressional race in CD4. Then, consultants Marcus Dell’Artino and Matt Grodsky discuss the fallout from the Cesar Chavez allegations and the political importance of high gas prices.
Stephen Curry nears return for Warriors, but will miss at least 2 more games as regular season winds down
Stephen Curry will have 10 games to play at most before the start of the play-in tournament.
Young scientists shine at Regional Science Olympiad
Budding young scientists from throughout the region participated in the 41st Annual Stanislaus County Regional Science Olympiad on March 14 at Modesto Junior College.
16 award-winning photographs from around the world
The Sony World Photography Awards announced the winning and shortlisted photographers of the 2026 National and Regional Awards .
Wrexham’s Hollywood owners’ Sky Sports’ watchalong criticised by Swansea CEO
Sky offered an alternative commentary with Wrexhman owners Ryan Reynolds and Rob Mac alongside regular presenter David Prutton.
Not all business owners: How Business for Good is building a new voice in San Diego
Business for Good, a network of San Diego business leaders, advocates for progressive causes in the region.
Orange County restaurants shut down by health inspectors (March 12-19)
There were 11 restaurants and food establishments ordered closed by Orange County inspectors from March 12 to March 19.
Should you try the 75 Hard challenge? Experts warn the risks may outweigh the benefits
The 75 Hard regimen demands 75 days of strict rules covering diet, exercise and reading. Experts explain what helps, what harms and smarter, sustainable alternatives.
Ancient DNA reveals a farming shift that pushed a society to the brink
A new study reveals that farming in Argentina’s Uspallata Valley was adopted by local hunter-gatherers rather than introduced by outside populations. Centuries later, a stressed group of maize-heavy farmers migrated into the region, facing climate instability, disease, and declining numbers. Despite these pressures, there’s no sign of violence—instead, families stayed connected across generations, using kinship networks to survive. The research shows how cooperation, not conflict, helped communities navigate crisis.
Here's How You Can Watch Sports With a VPN
A VPN can enhance your sports streaming by unblocking regional matches, circumventing geographical limitations or bypassing throttling restrictions.
The Science Behind the $19 Million Colostrum Craze: Miracle Cure or Marketing Myth?
Colostrum supplements are exploding in popularity, fueled by celebrity endorsements and loose regulation. But what does the science actually say?
‘Those days are over’: These business owners say they can’t raise prices even if they wanted to
Looking out his shop window, across the street, just to the right, Paloma Clothing co-owner Mike Roach sees one of Portland, Oregon’s, most expensive gas stations.
Department of Health retracts claim sunbeds are as dangerous as smoking
DHSC corrects statements after regulator intervenes as experts say smoking causes far more cancer cases
One arrested, another cited in shoplifting incident at business on East Avenue in Chico
CHICO, Calif. - A Paradise man was arrested and a Forbestown woman was cited by Chico Police in connection to a shoplifting incident at a business in Chico.The Chico Police Department says that at around 12:30 p.m. on Wednesday, March 18, a loss prevention employee observed two suspects stealing several items from a retail business on the 700 block of East Avenue in Chico.Upon exiting the building, the two suspects, a man and a woman, were contacted by the loss prevention employee regarding the stolen items. The employee was able to persuade both suspects to return to the store and hand over the items they had stolen.Authorities say the business expressed their desire to press charges against the suspects and contacted Chico Police to report the crime.Officers reviewed video surveillance that confirmed the employee's account of what happened. Officers then made arraignment for both suspects to turn themselves in the following day.When the suspects, identified as 51-year-old Jamie Leal of Forbestown and 62-year-old Melvin Royal of Paradise, arrived the next day to turn themselves in, authorities say both admitted to their involvement in the incident and elected to write handwritten apology letters to the business.Leal was cited by Chico Police on a misdemeanor charge of shoplifting.Royal was taken into custody and transported to the Butte County Jail, where he was booked on the following charges:Shoplifting with 2+ priors (felony)Shoplifting (misdemeanor) googletag.cmd.push(function() { googletag.display('ad-1514992'); });
Sorry, Amazon, you couldn't pick a worse time to bring a phone to market: IDC analyst
: The market is contracting
Group tied to Emily Gregory sends race-baiting text; Dems should condemn it
The biggest problem with the texts that went out is obviously that it’s racist. But the problems don’t stop there.
Prairieville’s Sarah Taylor is scaling a health network for industrial growth
As Ascension Parish’s industrial boom continues to draw contractors and skilled workers to the region, the demand for occupational health services is rising alongside it. NuREADY Health Network is expanding its footprint across the Gulf South to help companies manage workforce testing, injury care and compliance across multiple job sites. Major industrial construction and maintenance […]
US furiously seeks to avert potential months-long closure of Strait of Hormuz
US officials are furiously trying to avert a potential months-long closure of the Strait of Hormuz, privately acknowledging that reopening the key waterway is a problem without a clear solution and dependent at least in part on what lengths President Donald Trump is willing to go to force the Iranian regime’s hand, multiple administration and intelligence officials tell CNN.
Oregon voters overwhelmingly approved limiting money in politics. Then politicians had their say.
Oregon’s Democratic-controlled Legislature approved a bill that supporters described as containing little more than technical fixes to what they’d written two years ago.
Amazon is reportedly developing an AI-centric smartphone
Amazon's second smartphone could forego an app store.
[VIDEO] Lucy Wang Featured in Business Interview TV Series
Watch a new Business Insurance interview with Lucy Wang, discussing how California's historic insurance regulatory reform has impacted the state's insurance market and rates in response to increasing wildfire exposure.
Unknown Worlds co-founders' lawyers accuse Krafton of "intentionally leaking" Subnautica 2 release date
"Krafton self-servingly announced the launch without any regard to its impact on the game, the team, or the community," say lawyers
Federal judge in Oregon rules US government overreached with transgender health care declaration
The judge’s ruling Thursday in Oregon is part of multistate lawsuit filed against the U.S. Department of Health and Human Services, its secretary, Robert F. Kennedy Jr., and its inspector general.
US health department investigates 13 states that require insurance plans to cover abortion
HHS is looking into the states for ‘alleged disregard of, or confusion about’ the federal Weldon amendment
Regularly Playing This 1 Online Game May Reduce Dementia Risk by 25%
In TODAY.com's Expert Tip of The Day, a neurologist explains how playing games that build cognitive speed can protect against dementia for decades.
Why people are turning to salt rooms and halotherapy to unwind
Salt rooms regenerate health skin cells and boost our breathing. Here's what to look for when finding a salt room experience.
How did these flowers evolve to survive a megadrought?
A multi-year megadrought in the Western U.S. has claimed untold populations of wild plants. Amid the conditions, some have survived. Scientists have produced a stunningly complete picture about how populations of one particular flower – the scarlet monkeyflower – made it through. In a new study published in the journal Science, a team of scientists spent decades studying and sampling select populations of scarlet monkeyflowers in California and Oregon. Through genetic sequencing, the team discovered that the populations that did best went through genetic changes in a short time period. This is known as rapid evolution. The team found that three of the populations that recovered the BEST adapted their stomata to open less, so they could conserve more water. Stomata act like a plant’s pores, managing gas exchange and water loss. This allowed the scarlet monkeyflowers to hunker down in the drought and survive. Interested in more stories about rapid evolution? Email us your question at shortwave@npr.org.Listen to every episode of Short Wave sponsor-free and support our work at NPR by signing up for Short Wave+ at plus.npr.org/shortwave.Listen to Short Wave on Spotify and Apple Podcasts.This episode was produced by Jeffrey Pierre, Rachel Carlson and Hannah Chinn. It was edited by Christopher Intagliata and Rebecca Ramirez. Aru Nair checked the facts. The audio engineers were Becky Brown and Robert Rodriguez.
Judge Rules US Government Overreached With Transgender Health Care Declaration
PORTLAND, Ore. (AP) — A federal judge said the government overreached by issuing a declaration that called treatments like puberty blockers and surgeries unsafe and ineffective for young people experiencing gender dysphoria, according to a ruling Thursday in Oregon. Judge Mustafa Kasubhai's ruling ...
2 measles exposure sites identified at Salem health centers, Oregon officials say
PORTLAND, Ore. (KOIN) — Two Salem health centers were identified as the latest measles exposure sites in Oregon, officials said. The Oregon Health Authority and Marion County public health official…
Political influence ‘a serious problem’ for FDA under Trump, former commissioner says
Hundreds of individualized treatments for rare diseases could become available over the next decade — but only if government regulators handle the new
Dothan senior breaks 75-year barrier with international science fair qualification
Alexis Saffold earned her spot in the Regeneron International Science and Engineering Fair by turning an everyday problem into a potential breakthrough.
Mid-Ohio Valley Entertainment Commission hosts training session on film production
The Mid-Ohio Valley Entertainment Commission brought together film enthusiasts for a film crew training event at Marietta College on Sunday. The event sought to promote creativity and inspire filmmakers in the region. The event was originally scheduled for the entirety of the weekend but due to weather, the session was condensed to Sunday only. MOV […]
Mid-Ohio Valley Entertainment Commission hosts training session on film production
MARIETTA – The Mid-Ohio Valley Entertainment Commission brought together film enthusiasts for a film crew training event at Marietta College on Sunday. The event sought to promote creativity and inspire filmmakers in the region. The event was originally scheduled for the entirety of the weekend but due to weather, the session was condensed to Sunday […]
Trump administration probes states that mandate health insurance coverage for abortion
The Trump administration said Thursday that it has launched investigations into 13 states that require state-regulated health insurance plans to cover abortion.
Trump administration probes states that mandate health insurance coverage for abortion
The Trump administration said Thursday that it has launched investigations into 13 states that require state-regulated health insurance plans to cover abortion.
HOMETOWN ENTERTAINMENT: Weekend events across Southwest and Central Virginia
Concerts, a 5K and free family events are planned across the region this weekend
New dispute emerges around Subnautica 2’s early access release
Lawyers for the ousted—and now partially reinstated—leadership team of Unknown Worlds, the studio behind Subnautica 2, are crying foul over news that the game will be released into early access in May. The release announcement earlier this week was made improperly, potentially “damaging the game and sowing additional confusion among the Subnautica community,” the lawyers said in a letter sent on Tuesday to Vice Chancellor Lori Will of Delaware’s Court of Chancery. In their letter, the lawyers also floated the idea of asking Will to find Krafton in contempt of the court’s ruling. The letter was sent just one day after Will’s bombshell ruling that publisher Krafton had breached its contract with Unknown Worlds’ executive team, when it fired them last June. The new issue isn’t necessarily the May early access timeframe, but how the news was announced. The letter and Krafton’s response have not been previously reported. A quick recap of prior events: Subnautica 2 is an unreleased, underwater survival adventure and the most-wishlisted game on Steam. Last year, longtime Unknown Worlds CEO Ted Gill, along with studio co-founders Charlie Cleveland and Max McGuire, were fired by Krafton. They swiftly sued, saying the publisher had terminated them to avoid paying out up to $250 million in potential performance-based bonuses. The studio leaders had hoped to earn that with an early access release of the game, which Krafton had blocked. The publisher argued in court that Subnautica 2 wasn’t ready, which the ousted execs disputed. On Monday, Will ruled that Krafton had violated its contract, firing the execs to avoid the performance payouts, and that it had to reinstate Gill and give him full authority over any early access release for Subnautica 2. On Tuesday, IGN reported on a new memo issued that day to Unknown Worlds staff by Steve Papoutsis, the executive Krafton had put in charge of Unknown Worlds after the 2025 firings. In the note, Papoutsis said that Subnautica 2 had passed a key development milestone “last week” and that he and Krafton had determined the game “is ready for Early Access release in May.” This news appeared to catch the lawyers for Gill, Cleveland and McGuire by surprise. On Tuesday night, they sent a letter to Will expressing “serious concerns” about whether it would be possible to forge an agreement with Krafton consistent with the judge’s order. Papoutsis’ memo was a problem, they wrote. He didn’t have the authority to declare anything about Subnautica 2’s release. As of 9am ET on Monday, March 16, the effective date of Will’s order, Papoutsis wasn’t CEO of Unknown Worlds. Gill was. And, per Will’s order, only Gill could make Subnautica 2 release decisions. They continued: Krafton self-servingly announced the launch without any regard to its impact on the game, the team, or the community—let alone this Court’s Opinion. Announcing the release of a game is momentous, and it is typically accompanied by significant marketing activity, fanfare, and community coordination. And most importantly, the announcement is carefully designed to maximize excitement for the game. That entire process was supposed to be driven by Mr. Gill. However, in defiance of the Court’s Opinion, Krafton has now taken that away, further damaging the game and sowing additional confusion among the Subnautica community. The lawyers speculated that Krafton had “intentionally leaked” Papoutsis’ memo and then issued an official statement to confirm the leak. Game File is a reader-supported publication. My reporting is only possible through support from readers like you. To support my work, consider becoming a free or paid subscriber. Subscribe On Wednesday, lawyers for Krafton defended their client in their own letter to vice chancellor Will, saying nothing they did violated her order nor showed contempt: Papoutsis’s message was simply celebrating the UW employees’ efforts toward a past event: Krafton’s pre-Opinion determination that Subnautica 2 was ready for Early Access release. There was nothing improper about conveying the results of the milestone review or thanking the development team for their dedication and talent. They added that Gill could still make his own call about Subnautica 2’s release: In his role as CEO, Gill will be able to assess independently his views on the state of Subnautica 2 and the appropriate release schedule; nothing in Papoutsis’s message alters Gill’s authority or discretion. Vice chancellor Will has not responded to the letters and doesn’t necessarily have to. Both parties were previously ordered by Will to confer this week and submit a proposed judgment consistent with her ruling. The letter from Gill’s attorney’s this week doesn’t indicate whether he would or would not support a May release for Subnautica 2. But it could limit his options. And, if Gill’s lawyers are right, the lack of marketing fanfare around the leak of the May date could dull the launch of the game. Any harm to Subnautica 2’s launch is an extra sensitive issue given the context of the legal dispute: millions of dollars of payouts are on the line, tethered to the scale of the game’s initial performance. In her ruling on Monday, Will noted that there was obvious “bad blood” between Gill’s side and Krafton but that the two would need to work together: “They can—and must—act in good faith to navigate their remaining contractual relationship.” Item 2: A new kind of couch co-op game A highlight of GDC each year is the Alt.Ctrl showcase that features games played with extremely experimental controllers. Perusing this year’s offerings last Friday, I found a game controlled with giant scissors, another with big toothbrushes and one that amounted to dumpster diving. My favorite was Pivot, a co-op game about collectively maneuvering a couch. It was developed by students at the University of Utah’s masters of arts and engineering games program. Players lift and tilt the physical couch in order to control the position of a virtual one. That virtual one is moving through an obstacle course on-screen, while being pursued by a giant skull. Developer Nishant Verma told me at GDC that the couch is made of styrofoam (this became more evident as I watched!) and that the name was a riff on an episode of the sitcom Friends. Item 3: In brief… 🚫 Ubisoft is laying off more than 100 workers at its Red Storm studio, as the North Carolina location known for decades for its Tom Clancy games, ceases in-house game development, VGC reports. 👀 On Monday, Nvidia’s revealed its DLSS 5 AI-driven graphics technology that purports to improve game graphics… and it has been roasted about it by the media and the online gaming public for the remainder of the week. The tech changed the faces of characters in footage from Resident Evil Requiem, Hogwarts Legacy and EA Sports FC, drawing accusations of giving carefully art-directed games the generic look of AI “slop.” Nvidia CEO Jensen Huang had said on Monday that “DLSS 5 is the GPT moment for graphics—blending handcrafted rendering with generative AI to deliver a dramatic leap in visual realism while preserving the control artists need for creative expression.” By mid-week, Huang was telling Tom’s Hardware that the new tech’s critics were “completely wrong” because game-makers could still “fine-tune the generative AI” to suit their game’s aesthetics.
Democrats Demand Answers on Jared Kushner’s Mideast Business Dealings
Two prominent lawmakers wrote to the White House and Mr. Kushner after The New York Times revealed private fund-raising efforts by President Trump’s envoy in the region.
Providence looks to sell off its health insurance plan
In an internal email to staff, Chief Financial Officer Greg Hoffman said the organization’s top priority is “continuity and stability.”