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CCPS students place in 2026 science fair

Charles County Public Schools (CCPS) held the 10th annual History, Industry, Technology and Science Expo, also known as HITS, on March 21 at St. Charles High School. ​​​​​​​

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Mar 24 • 12:26 PM EDT • Science • ccboe.com
Senators consider deal to fund Homeland Security but not ICE enforcement

WASHINGTON (AP) — Senators raced Tuesday to clinch an emerging proposal to end the Homeland Security shutdown by funding much of the department, including the Transportation Security Administration airport workers going without pay, but excluding the ICE enforcement operations that have been core to the dispute. The sudden sense of urgency comes as U.S. airports […]

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Mar 24 • 12:25 PM EDT • Politics • coloradopolitics.com
Entertainment lineup announced for Red River Valley Fair

WEST FARGO (KFGO) - The Red River Valley Fair just announced the 2026 grandstand entertainment lineup, bringin...

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Mar 24 • 12:16 PM EDT • Entertainment • kfgo.com
Kari Nadeau named dean of the UCLA Fielding School of Public Health

Nadeau, currently chair of environmental health at Harvard’s T.H. Chan School of Public Health, will begin her new role in July.

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Mar 24 • 12:00 PM EDT • Health • newsroom.ucla.edu
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TSA lines are so bad that United, Delta waive change fees

Some airlines are waiving change fees or fare differences for passengers affected by hourslong waits at airport security.

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Mar 24 • 11:49 AM EDT • Business • businessinsider.com
Energy executive Alan Armstrong picked to fill Mullin's Senate seat through end of year

The choice by Republican Gov. Kevin Stitt, who had pledged to pick a “conservative voice” to fill Mullin's seat, elevates to the Senate the chairman and former CEO of Williams Companies, a major pipeline operator based in Tulsa.

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Mar 24 • 11:31 AM EDT • Politics • pbs.org
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Long lines at Texas airports continue as ICE agents assist strained TSA

Houston remains the only Texas city where ICE agents are currently assisting at airports, with personnel spotted at both William P. Hobby Airport and George Bush Intercontinental Airport.

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Mar 24 • 10:35 AM EDT • Politics • spectrumlocalnews.com
World Athletics Expands Air Quality Monitoring, But Can Sports Fill Global South’s Data Void?

The walk coordinators carried portable air quality sensors, logging particulate matter (PM)2.5 (fine particles) and PM10 (coarse particles), nitrogen dioxide

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Mar 24 • 9:50 AM EDT • Sports • healthpolicy-watch.news
Jimmy Kimmel Rips Into Trump Over Airport Security Chaos

The late-night host turns a 2016 Trump tweet against the president.

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Mar 24 • 8:22 AM EDT • Entertainment • cbs19news.com
The Morning After: WWDC 2026 is happening June 8th

The biggest news stories this morning: Wing expands its drone delivery service to the Bay Area, Billionaire OnlyFans owner Leonid Radvinsky has died from cancer at 43, Apple will reportedly start stuffing ads into the Maps app.

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Mar 24 • 8:15 AM EDT • Technology • engadget.com
Chris Froome Joins Vekta Leadership Team to Help Shape Sports Performance of the Future

Four-time Tour de France winner Chris Froome to join Vekta as Chief Innovation Officer and Chair of the newly created Vekta Athlete Advisory Board.

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Mar 24 • 8:00 AM EDT • Sports • insider.fitt.co
Texas oil refinery explosion sends smoke into air, residents advised to shelter in place

An explosion and fire at a Valero oil refinery has sent smoke rising into the sky in Port Arthur, where some residents are being told to shelter in place.

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Mar 24 • 7:36 AM EDT • Business • foxbusiness.com
Stellar Entertainment Partners with Parrot Analytics to Advance Data-Driven IFE

Stellar Entertainment and Parrot Analytics partner to bring real-time data into airline inflight content decisions.

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Mar 24 • 7:29 AM EDT • Entertainment • apex.aero
Why is AirDrop support disabled by default on Samsung Galaxy?

Samsung will officially start rolling out AirDrop support over Quick Share on Galaxy S26 devices throughout this week but, personally,...

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Mar 24 • 7:00 AM EDT • Technology • 9to5google.com
Blount: Online sports betting proposal has little support in Senate, would cost casino industry

Sen. David Blount, chairman of the Gaming Committee in the Senate, says a proposal to legalize online sports betting lacks support in the Senate, and could harm the state's casino tourism industry, which provides thousands of jobs and millions in state revenue. Blount also discusses proposed, and recently enacted, changes to the Public Employee Retirement System, and proposals to increase tax credits for private schools.

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Mar 24 • 7:00 AM EDT • Sports • mississippitoday.org
American Airports Are Latest Washington Battlefield | WSJ Politics Newsletter for March 24

Plus, the diplomatic back channel that led to Trump’s U-turn on the war

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Mar 24 • 6:59 AM EDT • Politics • wsj.com
ICE officers at airports a ‘test run’ for midterms, Steve Bannon suggests

Former White House strategist says current situation at airports will help ‘really perfect ICE’s involvement in the 2026 midterm elections’

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Mar 24 • 6:34 AM EDT • Politics • theguardian.com
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Accrington Victoria Hospital site to become health and care hub

Accrington Victoria Hospital closed in 2024 after the building was found to be beyond repair.

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Mar 24 • 6:11 AM EDT • Health • bbc.com
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Apple's iPhone Air is taking sales away from the iPhone 17 Pro while crushing the Galaxy S25 Edge

We don't have an exact sales figure for Apple's ultra-thin handset, but the iPhone Air is clearly more popular than some of you think.

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Mar 24 • 4:02 AM EDT • Technology • phonearena.com
I spent 4 hours in line at the TSA, and the situation felt dangerous

A couple traveling to Costa Rica for their anniversary vacation spent four hours at the TSA, missed their flight, and spent the night at the airport.

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Mar 24 • 12:02 AM EDT • Business • businessinsider.com
Trump’s New Political Tool: ICE

President Trump has increasingly used Immigration and Customs Enforcement to push personal and political objectives, and on Monday sent agents to airports across the country to help deal with long security lines.

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Mar 23 • 8:57 PM EDT • Politics • nytimes.com
Scientists say NAD+ could slow aging and fight Alzheimer’s and Parkinson’s

A global team of leading scientists is zeroing in on a tiny but powerful molecule that could reshape how we age. Known as NAD⁺, it plays a crucial role in keeping our cells energized, repairing DNA, and maintaining overall health—but its levels steadily decline over time, potentially fueling diseases like Alzheimer’s and Parkinson’s. Researchers are now exploring ways to boost NAD⁺ using compounds like NR and NMN, with early studies hinting at improvements in memory, metabolism, and physical function.

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Mar 23 • 8:00 PM EDT • Science • sciencedaily.com
From One Major to Three in Four Years: Connecting Data Science, German and Linguistics at Montclair

In a German language program for local children and on an archive translation project, Isabella Zarate Gonzalez shows how Montclair’s mix of STEM, world languages and community engagement helped her connect her interests into a single path

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Mar 23 • 8:00 PM EDT • Science • montclair.edu
Former Brazilian leader Bolsonaro's health improves and he could serve sentence under house arrest

One of his doctors says former Brazilian President Jair Bolsonaro has been transferred to a regular hospital room in the capital of Brasilia as he continues to recover from pneumonia

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Mar 23 • 7:45 PM EDT • Health • washingtonpost.com
I was on the Air Canada flight that crashed at LaGuardia

A 22-year-old student was on an Air Canada flight that crashed at LaGuardia Airport. He described the moment of the collision and the aftermath.

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Mar 23 • 5:37 PM EDT • Business • businessinsider.com
Why Wall Street seems to keep believing Trump

If you’ve been paying attention to, like, the news, you may be tempted to see Wall Street’s Monday morning 180 from despair to euphoria as a sign that stock traders are all a bunch of rubes.

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Mar 23 • 4:24 PM EDT • Business • cnn.com
Beyond the brackets, Florida seeks college sports solutions amid possible Trump action

“We don’t want to do something or say something that’s going to disadvantage these major institutions,” said Alan Levine, who chairs the Board of Governors.

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Mar 23 • 4:12 PM EDT • Sports • politico.com
Top business leader demands end to stalemate over City Council's pick for zoning chair

Chicagoland Chamber of Commerce President Jack Lavin said more than 40 development projects have been stalled by City Council's failure to agree on new permanent chair for the powerful Zoning Committee. He wants Mayor Brandon Johnson to forge a compromise to break the stalemate.

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Mar 23 • 2:47 PM EDT • Business • chicago.suntimes.com
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Airport chaos is adding urgency to the DHS shutdown debate. But who has the leverage?

DHS has been shut down for more than a month. But extremely long and growing TSA wait times have created newfound political urgency to reach a deal.

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Mar 23 • 2:40 PM EDT • Politics • cnn.com
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The live-action 'Moana' trailer debuts Dwayne Johnson as Maui — and fans can't stop talking about his hair

The remake of the 2016 animated film hits theaters July 10.

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Mar 23 • 1:42 PM EDT • Entertainment • yahoo.com
House GOP targeting vulnerable Dems over DHS shutdown, TSA chaos

The NRCC launches paid ads targeting Democrats in 28 districts, accusing them of shutting down DHS and forcing TSA agents to work without pay at airports.

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Mar 23 • 1:35 PM EDT • Politics • foxnews.com
Thousands in taxpayer funds spent on horse, hair and makeup expenses for Kristi Noem’s Mount Rushmore ad

Tens of thousands of taxpayer dollars were spent on expenses for hair and makeup artists and a horse for the advertisement showcasing outgoing Department of Homeland Security Secretary Kristi Noem in front of Mount Rushmore, according to invoices seen by CNN.

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Mar 23 • 12:51 PM EDT • Politics • cnn.com
iPhone Air Said to Be Roughly Twice as Popular as iPhone 16 Plus

While it certainly has its critics, the iPhone Air appears to have validated Apple's decision to retire the iPhone Plus, if new results from an independent analysis are anything to go by. Crowdsourced Speedtest data published by Ookla suggests the iPhone Air captured 6.8 percent of iPhone 17 generation samples in the U.S. during the fourth quarter of 2025, up from the 2.9 percent share the iPhone 16 Plus managed in the same launch window a year earlier.

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Mar 23 • 12:11 PM EDT • Technology • macrumors.com
STC HVACR student turns childhood lessons into vision for future business

Currently pursuing an associate degree in Heating, Ventilation, AC and Refrigeration (HVACR) at South Texas College, Cesar Bernal III said he was just 12 years old when he began watching his father turn determination and hard work into a small but thriving air-conditioning business in Weslaco.

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Mar 23 • 10:19 AM EDT • Business • news.southtexascollege.edu
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Xbox Partner Preview: Join Us on Thursday to See What's Next from Our Third-Party Partners

Our next Xbox Partner Preview airs Thursday, March 26 - with a whole load of world premieres, game updates, and much more.

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Mar 23 • 9:00 AM EDT • Technology • news.xbox.com
New York’s LaGuardia airport closed after plane collision with fire truck kills two pilots

About 40 people taken to hospital after Air Canada Express crash, some with serious injuries

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Mar 23 • 8:32 AM EDT • Politics • theguardian.com
By Director Mr. Sakurai, Kirby Air Riders: Development Insights — Part 5 - News

Join Kirby Air Riders director Masahiro Sakurai as he shares insights into the development and details behind some of the game's modes and features. Check out the rest of the interview Part 1: Air Ride and Top Ride Part 2: Cramming everything into S…

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Mar 23 • 8:00 AM EDT • Technology • nintendo.com
Starmer says ‘every lever’ will be explored to ease rising costs of living from Iran conflict

PM will chair Cobra meeting with key ministers and Bank of England on Monday, as experts warn of economic shock

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Mar 23 • 7:23 AM EDT • Politics • theguardian.com
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Samsung's Galaxy S26 will get Apple AirDrop support starting today

The feature was first launched on Pixel 10 phones last year.

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Mar 23 • 7:04 AM EDT • Technology • engadget.com
Report: iPhone Air is about twice as popular compared to the Plus model it replaced

According to cellular network data from Ookla, the iPhone Air is about twice as popular compared to the iPhone 16...

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Mar 23 • 6:53 AM EDT • Technology • 9to5mac.com
Cardinal Health Appoints Patricia A. Hemingway Hall as Board Chair

/PRNewswire/ -- Cardinal Health (NYSE: CAH) today announced that its Board of Directors has appointed Patricia A. Hemingway Hall to succeed Gregory B. Kenny as...

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Mar 23 • 6:45 AM EDT • Health • prnewswire.com
Samsung adds native AirDrop support to Galaxy S26 devices

Share files with Apple-using friends

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Mar 23 • 5:47 AM EDT • Technology • theverge.com
Ambani's Reliance Jio: businesses and investors of the IPO-bound firm

Indian billionaire Mukesh Ambani's Reliance Jio Platforms is gearing up to file papers seeking regulatory approvals for a Mumbai listing, in what is likely to be the biggest-ever stock offering in the country.

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Mar 23 • 5:39 AM EDT • Business • reuters.com
No 10 says Starmer had ‘constructive’ call with Trump on Middle East and strait of Hormuz

PM will meet with the Commons liaison committee and chair the government’s Cobra emergency committee today

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Mar 23 • 5:31 AM EDT • Politics • theguardian.com
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Exclusive | Lawmakers to Introduce Bipartisan Bill Banning Sports Bets on Prediction Markets

A bipartisan pair of U.S. senators are introducing legislation to prohibit CFTC-regulated entities from listing contracts related to sporting events.

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Mar 23 • 5:30 AM EDT • Sports • wsj.com
Personnel note: Tampa Electric names Ed Narain as Director of Regional Affairs

'Tampa Electric has a long history of supporting the growth and success of the communities it serves, and I look forward to helping strengthen those partnerships.'

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Mar 23 • 4:45 AM EDT • Politics • floridapolitics.com
Funding for populist-right ‘media-political complex’ exceeded £170m in five years, research finds

Handful of billionaires gave huge sums in particular to media organisations that boosted rightwing politicians, says Liam Byrne MP

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Mar 23 • 1:00 AM EDT • Politics • theguardian.com
St. Louis Blues Weekly Prospect Report (March 22)

Jiricek has big scoring week; McIsaac announces future plans; Ralph, Michigan State head to NCAA Tournament with Mayich, Clarkson University eliminated; Peterson scored pair, including a SH beauty for Springfield

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Mar 23 • 12:54 AM EDT • Sports • sports.yahoo.com
Scientists Trap Light in a Layer 1,000x Thinner Than a Hair

Scientists have found a way to trap light in an extremely thin layer, potentially reshaping how future photonic devices are built.

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Mar 22 • 10:07 PM EDT • Science • scitechdaily.com
The Economy Cabin on Airplanes Keeps on Shrinking

Carriers are expanding the options in premium cabins in a bid to boost their earnings.

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Mar 22 • 9:00 PM EDT • Business • wsj.com
Spring Health Fair delivers commitment to student wellness

The Student Wellness Advisory Committee hosted their annual Spring Health Fair on Friday afternoon where students were able to gain free tote bags, learn from live simulations and gain insight on new clubs and organizations centered on wellness.

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Mar 22 • 8:00 PM EDT • Health • ndsmcobserver.com
Wisconsin edges Ohio St., wins another title at Frozen Four

Claire Enright scored the go-ahead goal in the third period Sunday, Ava McNaughton had 34 saves, and No. 2 seed Wisconsin beat top-seeded Ohio State 3-2 at the Frozen Four to win its second consecutive national championship.

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Mar 22 • 7:21 PM EDT • Sports • espn.com
Samsung Brings AirDrop Support to Quick Share with Galaxy S26 Series

Samsung is introducing AirDrop support to the Galaxy S26 series, making it easier for users to share content between devices using Quick Share. The feature will begin rolling out from March 231, starting in Korea and expanding to more regions including Europe, Hong Kong, Japan, Latin America, North America, Southeast Asia, and Taiwan. AirDrop support […]

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Mar 22 • 7:00 PM EDT • Technology • news.samsung.com
Samsung rolling out AirDrop over Quick Share on Galaxy S26, more devices coming

Samsung has officially confirmed plans to start rolling out AirDrop support over Quick Share starting with the Galaxy S26 series...

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Mar 22 • 7:00 PM EDT • Technology • 9to5google.com
Former acting ICE director under Obama shares concern about ICE airport deployment
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Mar 22 • 4:42 PM EDT • Politics • cnn.com
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Federal union says 'untrained' ICE agents shouldn't replace TSA

President Donald Trump said he would tap ICE agents to run security at US airports as unpaid TSA officers stop showing up to work.

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Mar 22 • 3:12 PM EDT • Business • businessinsider.com
Your Thymus and Your Healthspan

Our thymus gland plays a central role in the development or our immune system, specifically for supporting T cell development (how these cells got their name, maturation and differentiation in the thymus) and discriminating between self and foreign, non-self antigen proteins with production of dendritic cells. As we age, our thymus gland shrinks—the process known as involution—with progressive change from spongy to fatty tissue, with loss of functionality. But this process, with respect to timeline and extent, markedly varies from one person to the next. And to make things even more complicated, our thymus gland anatomy and precise location in the chest also is highly variable. So the famous Frank Netter diagrams from the 1960s (such as at left below) don’t capture the remarkable heterogeneity that a random set of 12 chest CT scans (below at right). What I consider as 2 landmark papers in Nature this week (here and here) used AI to quantify health of the thymus in 2 large cohorts, and then correlate the metric to a broad array of health outcomes. In this edition of Ground Truths, I’m going to cover three questions: (1) How was thymus health determined by AI?; (2) How is thymus health linked to key clinical outcomes? and (3) Are there ways we can promote a healthy (aka rejuvenate) thymus gland in our later years? Subscribe 1. How was thymus health determined by AI? This was accomplished by extensive work developing and validating an AI pipeline for 2 stages, the first for localization and segmentation of the thymus bed, and the second to quantify a digital marker, termed the thymic health score. There’s a lot to this algorithmic development, so I won’t go into all the details, but just provide a rudimentary outline of what was done. The 1st stage used supervised learning with 2 radiologists reviewing 2,461 chest CT scans. That work trained a 3D U-Net model to automatically identify the thymic bed’s 3D cropped region using center of mass coordinates, which reached 99.8% accuracy. The 2nd stage used a foundation model that was pre-trained with SwAV (which stands for Swapping Assignment between multiple Views), a self-supervised model, that generated a high-dimensional thymus representation of 4,096 features. That compares to the radiology reductionist and subjective scoring of 0 to 3 where 0 means the thymus is fully degenerated and fatty, and 3 is considered dense, intact glandular soft tissue. Notably, the self-supervised learning (SSL) performance was superior to supervised (AUC ~0.75 vs 0.55, respectively) reflecting the shallowness of the 0-3 classifier vs SSL’s holistic, self-taught AI. The thymic health score ranged from 0 to 100, with the highest number indexed to fully preserved thymic health. The algorithmic work extended to explainability with both Shapely value distribution, meaning the model was holistic not relying on any “magic” pixel, and occlusion sensitivity, demonstrating the model’s performance was not affected by ribs, sternum, lung tissue, but rather focused on the thymic bed directly. Below are a few saliency maps from the occlusion sensitivity that indicate the thymic bed focus, not affected by neighboring structures, using the jet color scale. Now the AI was ready for processing ~25,000 CT scans, each over 30 MB files, from the 2 large participant cohorts to provide a thymic health score, it did so in less than 14 hours, which is less than 2 seconds per scan! Share 2. How is thymus health linked to key clinical outcomes? The two cohorts were the National Lung Screening Trial, NLST (N=25,031) and the Framingham Heart Study, FHS (N=2,581) each with baseline demographics and long term follow up of >12 years for health outcomes. From the NSLT, you can see below that increased age and body-mass index were correlated to reduced thymic health. And, overall, men had reduced thymic health scores compared with women. There are a lot of graphs in the paper for outcomes, for both the NLST and FHS cohorts. To simplify the major outcomes, below is a composite Figure with striking reduction of all-cause mortality and for the different causes of death. The results were consistent between the 2 cohorts. For example, the cardiovascular mortality hazard ratio average was 0.57 in NLST and 0.38 in FHS (weighted to be 0.53 for the aggregate). The reduction of mortality also extended to digestive diseases and pulmonary disease (data not shown below). Lung cancer incidence was reduced by 36% for high vs low thymic health (Figure below, with a panel -incidence and b panel-mortality, adjusted for age, sex, BMI, smoking status). Notably, there was a smoker’s paradox: lower incidence and improved survival for lung cancer in smokers who had a high thymus health score. Smoking was associated with lower thymic scores whereas alcohol was not. Higher thymic health was linked to higher HDL cholesterol, lower triglycerides, lower fasting blood glucose, and lower systolic and diastolic blood pressure. Inflammation biomarkers, such as C-reactive protein and interleukin-6, were elevated in the people with lower thymic health scores. In their second paper, the same team looked at the relationship between thymic score and outcomes for 3,476 patients receiving cancer immunotherapy. The non-small cell lung cancer progression-free survival was reduced in patients with low thymic health score. A parallel relationship for survival was seen for other types of cancer including melanoma, breast, and kidney with a 44% lower risk among high thymic scores (Figure). A similar pattern was seen with different immune checkpoint inhibitors. The thymus health score outperformed programmed death ligand-1 (PD-L1)and tumor mutation burden (TMB) assay of the tumor and was an independent prognostic marker of progression-free survival. In this dataset, a direct connect with thymus score and adaptive immune function was noted with a correlation before cancer treatment for both T-cell diversity and thymus T-cell production (a metric known as T cell receptor excision circles). Thymus Removal Study There is a highly relevant citation about thymus function before moving onto ways to rejuvenate it. In 2023, a very important study of thymus removal during cardiothoracic surgery was published, with 1146 patients undergoing thymus removal vs 1146 matched controls (mean age 55 years). The adverse outcomes for thymus removal were striking, with a 2.9 higher risk of all-cause mortality and doubling of cancer incidence, 1.5 fold increase in cancer mortality, and 1.5-fold increase in autoimmune diseases. The immune function showed marked compromise after thymus removal, as reflected by CD4+ and CD8+ T cells (Figure below) Share Ground Truths 3. Are there ways we can promote a healthy (aka rejuvenate) thymus gland in our later years? In recent months we’ve learned a lot about the process of thymus involution and the pathways by which this may be modulated. Thymus involution is primarily due to loss to thymus epithelial cells (TECs) and there are 2 subtypes with different functions: the cortical, responsible for positive selection of T cells, and the medullary, for negative selection. When adipose tissue infiltrates the thymus, thymic adipocytes are pro-inflammatory, knocking out T-cell output. Likewise, systemic inflammation, or “inflammaging,” from smoking, obesity, and chronic stress promote thymic adipocytes. Now, from preclinical studies, we know about key pathways that account for these processes. Historically, back in 2014, FOXN1 was recognized as a single master transcription factor essential for TEC function, with studies in mice with forced FOXN1 upregulation leading to thymus regeneration. That laid the foundation for potential regrowth of quiescent thymus cells. It took awhile to find pathways to accomplish this goal and to even refute its role as the master regulator. The Liver-Thymus Axis Feng Zhang and his team recently showed that injection of an mRNA vaccine to the liver encoding DLL1, IL-7 and FLT3-L in combination, factors known to support thymopoiesis (Figure), successfully enhanced immune function in aged mice. However, the effect was transient. The FGF21 Story Two reports in 2025 addressed the thymus gland’s production of FGF21, a growth factor (fibroblast growth factor 21) and its control of thymus involution. This growth factor is also produced by the liver, but it doesn’t have impact on the thymus in aged rodent models. In contrast, The liver’s hepatocyte growth factor (HGF) has been shown to reverse senescent TEC structural changes. Growth hormone stimulates production of insulin growth factor-1 (IGF-1) in the liver and the thymus. Two small studies in human participants (TRIIM, for Thymus Regeneration, Immunorestoration, and Insulin Mitigation) of 6 and 50 people, respectively, treated with combined human growth hormone, metformin and DHEA, suggested the potential of slowing epigenetic aging and improving thymus mass and function. But the combination of drugs, small sample, and lack of controls make conclusions murky. Increased thymus FGF21 led to increased CD8 T cells in old mice and extended healthspan and improved physical performance. Building on the previous FOXN1 data, ablation of β-klotho, the obligatory co-receptor for FOXN1, accelerated thymic aging. The benefit to FGF21 was confirmed in a companion paper using an FGF21 knock-in mouse model showing thymus enlargement and increased TECs throughout the lifespan. (schematic Figure below). The accompanying editorial for these 2 papers speculated: “The proposed link between age-associated thymus involution and organismal aging is intriguing, and suggests we might seek to achieve systemic rejuvenation by counteracting thymic involution.” Other Factors Lessons from the Axolotl (Mexican Salamander) In an elegant set of experiments of the axolotl (Figure), known for its complete thymus regeneration after total surgical removal, mediators were identified. Surprisingly FOXN1 was dispensable. But midkine, a growth factor, appeared to be the driver, the initiator of thymus cell growth, survival, and repair. Other components that contributed were Postn+ (periostin-expressing mesenchymal niches) and Ccl19, a chemokine protein from the bloodstream. RANK and RANKL RANK (receptor activator of nuclear factor κB its ligand (RANKL) have been considered key regulators of medullary TECs. In a study of both aged mice and human thymus cell cultures, their key role was confirmed, with multiple benefits of resorting TEC function, recruitment of progenitor cells, and T cell development. Subscribe Summing Up This body of work strongly supports the health of the thymus gland as a critical regulator of human healthspan, not just a correlate or link. The new landmark studies are reinforced by the regenerative biology experimental models that have shown, via an array of mediators, that healthspan of aged mice is at least in part dependent on thymus gland function and its critical role for maintaining adaptive immunity. It sure seems that we’d be better off having an immune reservoir of naive T cells instead of a profile in older adults of exhausted, low quality, memory T cells, with a senescent phenotype. It is striking that we ignored the importance of the thymus gland for many decades. A wake-up call was the results of the thymectomy matched control study reviewed here, with the opposite of high thymic health score improved health outcomes. The convergence of AI and healthspan here is notable. The exceptional and laborious work for developing and validating (no less explaining) the AI to quantify thymus health set the foundation for probing the connect the major health outcomes in two cohorts with extensive follow-up. We’ve never had a way to meaningfully quantify the thymus gland before, so this represents important leverage of supervised, self-supervised, and transformer models. The study wouldn’t have been possible without AI. And it begs the question as to whether there are ways we can maintain our thymus at a high health score. But it’s not so simple to rejuvenate our thymus. There are multiple risks including the induction of autoimmunity, increasing the risk of cancer, and inducing a pro-inflammatory state. For example, factors that increase TEC proliferation could compromise the medulllary negative selection process and leak out auto-reactive (self-attacking) T cells. Thymic cells could be induced to proliferate, but we know, for example, that growth hormone and IGF-1 are associated with an increase risk of cancer. If thymus rejuvenation doesn’t clear out the accumulated senescent cells in older adults, then inflammation within the gland could block the production of TECs. Keeping these risks in mind, we now have identified many ways to keep our thymus healthy as we age that undoubtedly will be tested in clinical trials going forward. Ultimately, the benefit-to-risk tradeoffs will be defined. In the meantime, we have desperately needed an immunome. As I’ve stressed in multiple prior Ground Truths, we have no test in the clinic to assess a patient’s immune status! It was very encouraging for me to get an email from Hugo Aerts, the senior author of the landmark papers in the days after they were published: “I also wanted to say that your Substack on “Why We Need an Immunome” was inspiring for this work. We found it a very compelling perspective and greatly enjoyed reading it.” Just having an assessment of a person’s immune status via a chest CT scan, with millions of these performed per year, might help in guiding the right immunotherapy for cancer (e.g. more intensive, combinations for those with low thymic health scores) and help define people who are increased risk for age-related diseases of cancer, cardiovascular, and neurodegenerative. The main theme of Super Agers is that we now have many layers of data (genetics, proteins, biomarkers, organ clocks that can be integrated via multimodal AI) for us to define a person’s specific risk decades before one of these age-related diseases leads to symptoms, enabling prevention. From the new studies this week, we can add thymus health score as yet another way to understand a person’s risk, a window into their adaptive immune system and healthspan. And perhaps someday we will be able to safely rejuvenate the thymus, or maintain its health through one’s life, and use the thymus health score to monitor. NB: I wrote this post (No A.I.) A Quick Poll Loading... ********************************************************************* Thanks to Ground Truths subscribers (now > 200,000) from every US state and 212 countries. Your subscription to these free essays and podcasts makes my work in putting them together worthwhile. Please join! If you found this interesting PLEASE share it! Share Ground Truths Paid subscriptions are voluntary and all proceeds from them go to support Scripps Research. They do allow for posting comments and questions, which I do my best to respond to. Please don’t hesitate to post comments and give me feedback. Let me know topics that you would like to see covered. Leave a comment Many thanks to those who have contributed—they have greatly helped fund our summer internship programs for the past two years. It enabled us to accept and support 47 summer interns in 2025! We aim to accept even more of the several thousand who will apply for summer 2026.

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Mar 22 • 2:18 PM EDT • Health • erictopol.substack.com
Politics Now: March 22, 2026

This week on Politics Now with host John Langeler: Nevada is trying to lessen its reliance on fuel from California. We talk with the vice-chair of the committee tasked with determining how to do th…

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Mar 22 • 2:01 PM EDT • Politics • 8newsnow.com
United Airlines Just Issued a Playbook for Any Business Staggered by Skyrocketing Costs

In a letter to employees, CEO Scott Kirby delivered a master class on boosting morale as he deals with the impact of surging jet fuel prices.

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Mar 22 • 1:52 PM EDT • Business • inc.com
70 judges peruse hundreds of science fair projects at Interior science fair

Fourth-grader Lexi Snow wondered why she always blushes.

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Mar 22 • 10:00 AM EDT • Science • newsminer.com
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Acuff scores 36 as Arkansas holds off No. 12 seed High Point 94-88

Two of the highest-scoring teams in the nation combined on a back-and-forth affair that featured 15 lead changes and six ties.

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Mar 22 • 8:28 AM EDT • Sports • spectrumlocalnews.com
This floating time crystal breaks Newton’s third law of motion

Scientists have created a new kind of time crystal using sound waves to levitate tiny beads in mid-air. These particles interact in a one-sided, unbalanced way, breaking the usual rules of motion and creating a steady, repeating rhythm. The system is surprisingly simple yet reveals complex physics with big implications. It could help advance quantum computing and deepen our understanding of biological timing systems.

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Mar 22 • 8:00 AM EDT • Science • sciencedaily.com
Golden Knights intent on igniting sluggish offense vs. Stars

With 12 games left in the regular season, it's fair to say that things are trending in the wrong direction for the Vegas Golden Knights.

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Mar 22 • 7:49 AM EDT • Sports • cbssports.com
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We Took Our Three-Year-Old On A Long Haul Flight, And It Was Amazing!

We took our three year old on his first long haul flight in nearly two years. It went so much better than I could have anticipated!

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Mar 22 • 6:50 AM EDT • Technology • onemileatatime.com
Project Hail Mary is packed with hard science

The movie “Project Hail Mary” stars Ryan Gosling as a reluctant astronaut on a mission to save Earth. Here’s the science that the movie gets right.

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Mar 22 • 6:12 AM EDT • Science • earthsky.org
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U.S. health care system is beyond repair

Letters to the editor for Sunday, March 22, 2026

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Mar 22 • 6:01 AM EDT • Health • news-press.com
Deals: Galaxy S26 series gets its first price drop, the Pixel 10 series drops even further

Meanwhile, the 2025 MacBook Airs are getting cheaper too - not quite as cheap as the Neo, but they are an important alternative for those who need more RAM.

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Mar 21 • 9:31 PM EDT • Technology • gsmarena.com
Curzan lifts Virginia women to sixth straight NCAA swim title

Claire Curzan finished off a sweep in the backstroke on Saturday to help lead the Virginia women to their sixth straight NCAA swimming and diving championship on Saturday.

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Mar 21 • 8:59 PM EDT • Sports • espn.com
Utica University Science Fair Inspires Young Scientists

Young scientists from local middle and high schools gathered for the 47th annual Utica University Regional Science Fair.

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Mar 21 • 8:30 PM EDT • Science • wktv.com
I let AI pick my Oscars ballot. It messed up oddly, but still won.

Alistair Barr's AI-assisted Oscars ballot, powered by Anthropic's Claude, outperformed despite missing some categories.

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Mar 21 • 7:26 PM EDT • Business • businessinsider.com
Milwaukee stair climb raises awareness for lung health and firefighters

The American Lung Association hosted its 18th annual stair climb in Milwaukee, where participants, including firefighters, climbed 30 stories to raise funds and awareness for lung health.

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Mar 21 • 6:59 PM EDT • Health • wisn.com
47th annual Utica University science fair shows area students are smarter than ever

Four dozen science projects from 60 students from eight area schools competed for the top prizes at the Donohue Concourse underneath the Frank Gannett Library. Some of the topics may have changed over the years — there were no baking soda volcanoes — but the students still displayed their projects on decorated posterboard for staff, family and the judges to see. The projects were split between the junior division — 7th and 8th grades — and the senior division — 9th through 12th grades.

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Mar 21 • 5:00 PM EDT • Science • romesentinel.com
Trump threatens to deploy ICE agents to airports Monday if funding deal isn’t reached

President Donald Trump said Saturday he will deploy Immigration and Customs Enforcement agents to US airports on Monday if an agreement isn’t reached to fund the Department of Homeland Security amid a partial government shutdown.

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Mar 21 • 2:48 PM EDT • Politics • cnn.com
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Fed’s Powell Lauds Volcker Record in Face of Political Pressure

Federal Reserve Chair Jerome Powell on Saturday lauded the policy record of the late Fed Chair Paul Volcker, who raised interest rates and sparked a recession to tame the high inflation that took off during the 1970s.

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Mar 21 • 1:30 PM EDT • Politics • bloomberg.com
Hundreds of Thousands of Czechs Rally in Anti-Government Protest

Hundreds of thousands of people rallied in the Czech capital of Prague in a demonstration against the cabinet led by billionaire Prime Minister Andrej Babis.

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Mar 21 • 12:40 PM EDT • Politics • bloomberg.com
Farmers and rural community members can access free mental health resources

KGAN CBS 2 and KFXA Fox 28 provide local news, weather forecasts, notices of events and items of interest in the community, sports and entertainment programming for Cedar Rapids and nearby towns and communities in the Corridor and throughout eastern Iowa, including Iowa City, Waterloo, Dubuque, North Liberty, Coralville, Marion, Morengo, Williamsburg, Washington, Tiffin, Tipton, Solon, Mount Vernon, Lisbon, Central City, Urbana, Independence, Manchester, Dyersville, Oelwein, Cedar Falls, Waverly, Evansdale, Guttenberg, West Union, New Hampton, Decorah, Waukon, Maquoketa, Sigourney, Fairfield, Grundy Center, La Porte City, Dysart, Fayette, Elkader, Strawberry Point and Belle Plaine.

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Mar 21 • 12:14 PM EDT • Health • cbs2iowa.com
Unfriendly skies: Ron DeSantis floats privatizing TSA after Elon Musk pay promise

'Why not let the airlines and airports handle it?'

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Mar 21 • 11:34 AM EDT • Politics • floridapolitics.com
Apple M5 MacBook Pro and Air Review: When the Neo Isn’t Enough

Apple’s new laptops and high-end display fit the bill for the company’s most demanding customers.

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Mar 21 • 11:00 AM EDT • Technology • bloomberg.com
Doctors are in: Stuffed animals get health checks at zoo's Teddy Bear Care Fair

Toddlers Eliza and Olivia Altman watched attentively as Toledo Zoo & Aquarium volunteers performed “surgery” on their nearly decapitated stuffed animals ...

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Mar 21 • 10:26 AM EDT • Health • toledoblade.com
These are my favorite budget-friendly iPhone 17e accessories

Best budget accessories for iPhone 17e: cases, chargers, MagSafe gear, AirPods, and more to upgrade your setup for less.

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Mar 21 • 9:30 AM EDT • Technology • 9to5mac.com
A massive freshwater reservoir is hiding under the Great Salt Lake

A hidden freshwater system deep beneath the Great Salt Lake has been revealed using airborne electromagnetic surveys. Scientists found that freshwater extends much farther under the lake than expected, reaching depths of up to 4 kilometers. The discovery began with mysterious reed-covered mounds formed by pressurized groundwater pushing upward. Researchers are now investigating whether this underground water could help control hazardous dust from the drying lakebed.

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Mar 21 • 8:00 AM EDT • Science • sciencedaily.com
Billionaires, trial lawyers and unions gear up for 2026 California ballot brawls

It costs millions to qualify for the ballot and most measures fail, but that’s not stopping lots of special interest groups from trying

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Mar 21 • 8:00 AM EDT • Politics • sacbee.com
Elon Musk offers to pay TSA workers' salaries amid DHS budget standoff

Elon Musk has offered to cover the salaries of TSA personnel during the ongoing funding impasse disrupting airports nationwide.

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Mar 21 • 7:07 AM EDT • Business • foxbusiness.com
The insular bubble of caucuses and assemblies

Nearly 30 years ago, then-Federal Reserve Chairman Alan Greenspan coined the term “irrational exuberance” to describe the overheated stock market. That descriptive phrase could also apply to much of the political realm. The hype in politics often grossly exceeds the reality on the ground. In that vein, let’s focus on Colorado’s precinct caucuses held earlier […]

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Mar 21 • 7:00 AM EDT • Politics • coloradopolitics.com
Billionaire John Caudwell's rules for parenting his 8 kids

British billionaire John Caudwell says he flies his kids economy, shops at Primark, and always tells them he loves them.

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Mar 21 • 5:59 AM EDT • Business • businessinsider.com
Martin Parr's Last Hurrah

Two new coffee-table books revisit the late photographer's wry images—and the environmental warning simmering beneath them.

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Mar 21 • 2:00 AM EDT • Entertainment • airmail.news
Apple Has Unveiled 9 New Products This Month

Apple has unveiled a whopping nine new products so far this March, including an iPhone 17e, iPad Air models with the M4 chip, MacBook Air models with the M5 chip, MacBook Pro models with M5 Pro and M5 Max chips, the all-new MacBook Neo, an updated Studio Display, a higher-end Studio Display XDR, AirPods Max 2, and Nike Powerbeats Pro 2.

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Mar 20 • 5:39 PM EDT • Technology • macrumors.com
Opinion | Why the Trump FCC Cares About Your Sports Viewing

Its irrepressible chairman never runs out of ways to advance the president’s political interests.

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Mar 20 • 4:57 PM EDT • Sports • wsj.com
Hawaiian Airlines Boeing 787-9 Dreamliner business class review

Hawaiian Airlines' Dreamliners' stunning business class features privacy suites, closing doors, creative menus, and colorful Hawaiian accents all over.

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Mar 20 • 4:54 PM EDT • Business • thepointsguy.com
Whitman School Announces Alumnus, Business Leader as 2026 Convocation Speaker

Steven W. Barnes ’82, H’19, a senior advisor at Bain Capital and former Board of Trustees chair, will address graduates at the May 9 ceremony.

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Mar 20 • 4:30 PM EDT • Business • news.syr.edu
Far-left surge in Airbus’ hometown scares big business

Employers brace for France Unbowed’s possible takeover of city hall in Toulouse.

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Mar 20 • 4:00 PM EDT • Business • politico.eu
Prairieville’s Sarah Taylor is scaling a health network for industrial growth

As Ascension Parish’s industrial boom continues to draw contractors and skilled workers to the region, the demand for occupational health services is rising alongside it. NuREADY Health Network is expanding its footprint across the Gulf South to help companies manage workforce testing, injury care and compliance across multiple job sites. Major industrial construction and maintenance […]

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Mar 20 • 3:08 PM EDT • Health • businessreport.com
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House Republicans subpoena prosecutor for records tied to Stephen Miller protester

The demand comes after Rep. Jim Jordan, chairman of the House Judiciary Committee, opened an inquiry into Parisa Dehghani-Tafti, Arlington County’s lead prosecutor.

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Mar 20 • 2:25 PM EDT • Politics • washingtonpost.com
35 photos that show what life looked like in 1973

A senior portrait so perfectly 1973 it could have been Michael Kelso's yearbook photo — the side-swept hair, the wide lapels, the expression of a guy who knows exactly how good-looking he is. The menu behind him says coffee is 15 cents.

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Mar 20 • 1:04 PM EDT • Technology • aol.com
The MacRumors Show: Surprise AirPods Max 2 Announcement

On this week's episode of The MacRumors Show, we discuss Apple's surprise announcement of the AirPods Max 2 this week. Subscribe to The MacRumors Show YouTube channel for more videos The AirPods Max 2 introduce a range of improvements primarily driven by the addition of Apple's H2 chip, which replaces the H1 chip used in previous models.

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Mar 20 • 12:58 PM EDT • Technology • macrumors.com
M5 MacBook Air vs. M5 MacBook Pro Buyer's Guide

Both the MacBook Air and entry-level MacBook Pro now feature the M5 chip, so how do the latest models compare? While the 13-inch MacBook Air starts at $1,099 and the 15-inch model at $1,299, moving to the 14-inch MacBook Pro requires spending at least $300 more.

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Mar 20 • 12:08 PM EDT • Technology • macrumors.com
Ohio airman's father says his son's death should not be 'political springboard'

Charles Simmons son was killed in a March 12 crash in Iraq. The grieving father said he doesn't want his son's death used as a talking point.

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Mar 20 • 12:01 PM EDT • Politics • dispatch.com
Scientists Make a Major Breakthrough in Solving a Hair-Raising Mystery About Static Electricity

The findings can help explain the physics behind phenomena like volcanic lightning

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Mar 20 • 11:29 AM EDT • Science • smithsonianmag.com
Agnes Pockels’ pioneering work was unfairly dismissed by tropes about women’s domestic roles

Agnes Pockels achievements in surface science have long been overshadowed by a popular and likely untrue story that she became interested in the subject while doing the dishes

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Mar 20 • 11:00 AM EDT • Science • scientificamerican.com
Apple to Launch More New Hardware This April

Apple isn't done yet. After announcing seven new products in March – including the iPhone 17e, iPad Air, MacBook Air, MacBook Pro, MacBook Neo, Studio Display, and Studio Display XDR – the company has one more launch on the books in the coming weeks (as far as we know, at least). AirPods Max 2 go up for pre-order on March 25, with availability beginning in early April.

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Mar 20 • 10:47 AM EDT • Technology • macrumors.com