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Starbucks raises health insurance premiums, sparking worker tension
Rising costs for health insurance premiums offered to Starbucks workers are sparking tension.
Three-time MVP Aaron Judge returns to Yankees
BRONX, N.Y. (WIVT/WBGH) – Sticking with the diamond, let’s move up to the major leagues where the Yankees are set to welcome back the captain tonight. Aaron Judge is making his return in the pinstripes tonight. No. 99 ironically had a 99-day absence after he suffered a broken rib. The three-time AL MVP missed 84 […]
Dueling Court Rulings Leave Missouri’s Congressional Races in Chaos
After losing in two courts and winning in another, Missouri officials said they planned to forge ahead with using a congressional map that was redrawn to benefit Republicans.
Data center backlash reveals bugs in the political system - or are they features?
Local officials have more power than they're letting on in the fights over data centers.
Newcastle battle past Millwall to reach League Cup fourth round
Newcastle battled into the League Cup fourth round as Joe Willock's late goal sealed a bruising 1-0 win against Millwall on Tuesday.But Newcastle survived to keep alive their bid to win the League Cup for a second time in three years.
Severe Warning Issued Over Technique Putting Patrick Mahomes at Risk
The Kansas City Chiefs fans are still not completely certain whether Patrick Mahomes will be starting in the season’s opening Week 1 game. The team suffered heavily last season when the quarterback suffered an ACL injury that has kept him out for a long time. He has missed the entire offseason, including the preseason games. […] The post Severe Warning Issued Over Technique Putting Patrick Mahomes at Risk appeared first on Gridiron Heroics.
September 10 Vallejo/Vacaville Arts-Entertainment Source: Activities
A National Day of Service and Remembrance is set for Saturday at 10 a.m. in Dixon.
GOG brings back "big box" PC games, one printable template at a time
Preservation "goodies" also includes downloadable 3D models for desktop perusal.
Dolly Parton's sister slams 'fake AI garbage' following icon's death
In a Sept. 4 Instagram statement, Dolly Parton's sister Stella Parton thanked fans for the “genuine” support, urging supporters to use her sister’s life as an “example for tolerance and respect towards others.”
Sonoma County delays opening of El Verano behavioral health facility for second time this year
The facility in El Verano — which would bring services closer and expand homelessness services to Sonoma Valley residents and which county officials had called “a big win for the Valley” — was originally expected to open in June.
Rosanne Cash postpones tour dates following medical emergency
Singer-songwriter Rosanne Cash has postponed upcoming concert dates in Wyoming and Montana following a medical emergency under doctor's orders.
Haaland double powers Man City to victory over Porto
Erling Haaland scored twice as Manchester City began their Champions League campaign with a 2-0 victory at Porto.This time, though, they got the second goal to kill Porto off as Haaland slotted in Rayan Ait-Nouri's cross for his 59th Champions League goal in 59 games in the competition. kca/iwd/nf
Politics News Site NOTUS Rebrands as The Washington Sun
A trademark dispute scuttled its plans to relaunch as The Washington Star, so the site chose a different name.
Red Dead Redemption 2 free expansion is a new story set within an alternate timeline
If you need more post-game content, you've found it.
Why Are So Many Parked Cars Catching On Fire?
When I was about nine years old, I was riding in the back of my family’s old ’68 Volkswagen Beetle when the car started to lose power and slow down. My mom, who was driving at the time, began to pull over to the side of the road, and at that moment I looked behind […]
Apple Releases Firmware Update for 140W USB-C Power Adapter
Apple today released a firmware update (version 1.4.90) for its 140W USB-C Power Adapter. It is unclear what is included in the latest firmware, as Apple does not publish release notes for this. The update will be installed automatically over time when the power adapter is plugged in and connected to a Mac or other device. The update will be installed automatically over time when the power adapter is plugged in and connected to a Mac or other device.
Fairfax Family Practice Centers selects new CEO
Fairfax County-based Fairfax Family Practice Centers has a new full-time CEO, with Frank Mencini beginning the role last week.
The Villages Health’s $541 million settlement highlights the cost of ‘upcoding’
The settlement describes how The Villages Health would go back into patients' medical files months later and add diagnoses -- sometimes adding in monitoring, evaluations or treatments.
Meet the Candidate: Ben Ivey seeks 120th District Judge seat
The El Paso Times sent questionnaires to candidates in the 2026 Nov. 3 General Election. Here are answers from 120th District Court judge candidate Ben Ivey.
Exclusive: Two of gaming’s biggest names are making a big investment in gaming’s future
The first thing to know about the Nova Games Foundation is that it isn’t about The Game Awards. And it’s not about PlayStation. The ambitious new grant program is the brainchild of Geoff Keighley and Mark Cerny. Keighley is the host of The Game Awards, Summer Game Fest and Opening Night Live. Cerny is a game designer of some 45 years and the lead architect for the PlayStation 4 and 5. But this new thing, which they’re revealing through Game File, isn’t about their day jobs. It’s an unaffiliated, standalone philanthropic project. It’s a bet on the artistic future of video games and a way, they tell me, to give back. “I’m nearing the end of my career,” Cerny recently told me over email. “I’m not done yet, but paying it forward—in the best way possible—is very much on my mind these days,” The Nova Games Foundation is a university-affiliated fellowship program, intended to offer six-figure grants to 20 young game designers each year, potentially for decades to come. It will offer no-strings-attached funding along with mentorship from games industry leaders, a combination intended to aid the development of groundbreaking new games, Cerny and Keighley told me. Nova will begin accepting applications in December, from class of 2026 and 2027 students from 13 affiliated gaming programs at universities in eight countries. The schools working with Nova include the New York University and the University of Southern California in the U.S., along with Abertay University in Scotland, Cnam-Enjmin in France, TH Köln in Germany, and the Royal Melbourne Institute of Technology in Australia, Cerny and Keighley said. The plan: $100,000 per recipient, with about a quarter of Nova fellows eligible for up to $500,000 more for projects that are shaping up particularly well. Payments will be delivered based on development milestones, and recipients will own their games. Nova will help promote the work, and developers will be free to pursue the publishers and platforms of their choice. Nova can help introduce fellows to publishers, but won’t take a cut. “I’ve always wanted to give back, but given my role in the industry, I’ve never felt it appropriate to commercially invest in games,” Keighley told Game File. “I’ve never owned stock in a game company or taken a financial stake in a game. Nova is philanthropy: we aren’t taking equity or looking to recoup the grants. The return we’re hoping for is creative—helping new voices make games and find their footing. “Mark and I have each made multi-million-dollar donations to establish the foundation, and we intend to keep contributing. We hope others will join us.” Cerny and Keighley have already hired an executive director, John Maconga, and a head of grants, recent Game Developers Conference director Ashley Corrigan, to help launch the effort. They’re working to recruit game industry leaders to join the effort. Keighley says “dozens of leading game directors have already expressed interest in contributing their time.” To name one, they’ve already gotten Josef Fares, lead designer from It Takes Two and Spit Fiction studio Hazelight on board with a donation and pledge to help out. “I’m proud to support Nova because it gives the next generation of creators the freedom to explore their creativity and hopefully bring their unique visions to life,” Fares told Game File. A plan forged from a friendship Keighley and Cerny have known each other a long time. It’s been so long, Cerny isn’t even sure exactly when they met. “We travel in much the same circles and I’m sure first intersected in the 90s or early 2000s,“ Cerny said. Keighley thinks it might have been during his stint writing a column about the mid-’90s console 3DO for a gaming magazine while Cerny was working on games with Crystal Dynamics or on Way of the Warrior with Naughty Dog. They became genuine friends about a 10 years ago, Keighley said, as they bonded over a shared love of games and a hope to improve the industry. “About a decade ago, we started having dinner a few times a year in LA,” Keighley said. “Just to catch up on life and the industry. Those conversations continued over Zoom during COVID. Nova grew out of that friendship and a question we kept coming back to: ‘What could we do to help the next generation of game directors get started?’” Keighley credits Cerny with the idea to figure out a way to put their money and time back into the industry. At one of those dinners, Keighley proposed the idea of a fellowship program. He’d recalled applying for a Rhodes Scholarship when he was younger. “Spoiler: I didn’t get it,” he said. He’d admired the MacArthur Foundation’s so-called “genius grants.” He liked these kinds of programs that recognized people’s talents and gave them the financial boost and the freedom to realize their potential. With Cerny, he had pondered what a game industry version of that could be. Keighley liked the idea of centering the fellowship on students, drawing inspiration from the accomplishments of Jenova Chen, the USC game design graduate who went on to lead the creation of gently moving, ambitious games such as Flower and Journey. Keighley also thought it could be useful to help promising graduates bridge the transition from student to professional. “Joining an established studio isn’t always possible—especially in today’s market—and even then, it isn’t the right path for everyone,” Keighley said. A fellowship, he realized, could give “graduates the time, resources and guidance to pursue a game of their own and not worry about the commercial viability.” As the idea took shape, Cerny also saw an opportunity to enable more games of a certain type: “The target with the grants is games as an artistic medium,” Cerny told me. “We like to say games with ‘artistic, literary and societal value.’” He added: “I’m a pretty big gamer myself, though I tend to gravitate towards the smaller and more unique or artistic titles, games like Neva, Abzu, Gorogoa, Stray or Outer Wilds. I was just playing and Roger on a flight to Japan, and was getting misty eyed to a degree that I was concerned that a flight attendant would ask me if I was OK. “So one fun benefit here is the games that will come out of the Nova Games Foundation – I can’t wait to play them myself.” Cerny believes it will also be useful for Nova fellows to hone their craft and team leadership skills. “We are looking for the next generation of visionaries,” he said. “The trick is that they will also need to have the executive function necessary to drive a small project to completion.” Game File is a reader-supported publication. To receive new posts and support my reporting, please consider becoming a free or paid subscriber. Subscribe Going big with this Keighley and Cerny may have started Nova and may be the ones primarily backing it right now, but they’re dreaming of something that goes beyond them. “Mark and I may have helped get it started, but one of our measures of success is that Nova grows into something the entire games industry feels a sense of ownership in,” Keighley said. “Our ambition is to build a lasting endowment supported by people and companies across the industry, and an equally broad community of creators willing to give their time and experience to the next generation.” The industry has a lot of knowledge that it can pass to the next generation, Keighley said: “Nova can hopefully become a way to connect that generosity with talented young creators at the moment when it can make the biggest difference.” Cerny, who told me he believes Nova can mature “over the next 10 or 20 years,” sees an opportunity to give generations of game makers momentum. “The industry has changed immeasurably since I started in games in 1982,” he said. “These graduates have talent, training and tools that outclass what we had back in the day by an astonishing amount. But they face a tough road ahead getting traction in the industry, and many could benefit from our support. We want to be there to give it to them.” “There’s a personal side to this, too,” Keighley said. “I don’t have children, and I’ve spent a lot of time thinking about what I can do for future generations. Games have been my entire career. I’ve been incredibly fortunate, and helping someone else build a life in this industry feels like a meaningful way to give back.” Cerny’s oeuvre dates back to Marble Madness and Sonic the Hedgehog 2. He has stood on stage multiple times to reveal the future of PlayStation hardware. He’s been an executive producer for a string of modern PlayStation classics such as The Last Guardian and Marvel’s Spider-Man. Nevertheless, of Nova, he said, “It’s certainly not like anything I’ve done before.” Nova Foundation applications will be due in December and the first wave of fellows will be announced in March 2027. A full list of participating universities and steps students and recent graduates can take to apply to become a Nova Fellow is forthcoming.
Cannibalism returned to the menu multiple times in Neolithic Europe
Bones collected from three caves in Spain reveal how cannibalism came back over thousands of years.
Russell Peters opens up about race, politics and why he still needs comedy
Russell Peters talks race, prejudice, politics, and why making people laugh still matters.
KCENNews
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Study finds social, financial, and healthcare factors shape resilience in adults with sickle cell disease
A new study explores how individual and community health experiences of adults with Sickle Cell Disease (SCD) shape resilience — the capacity to adapt to adversity.
Mysterious elk deaths in Nevada could offer clues about health of herds across the West
An unusual pattern of springtime elk deaths for more than a decade in northern Nevada has scientists searching for answers. What they find could shed light on broader questions about wildlife health across the West.
Mysterious elk deaths in Nevada could offer clues about health of herds across the West
An unusual pattern of springtime elk deaths for more than a decade in northern Nevada has scientists searching for answers. What they find could shed light on broader questions about wildlife health across the West.
Trump Administration Asks Supreme Court to Allow Voter-Screening Tool
Voting rights organizations had challenged a Trump administration overhaul of a government database, arguing it could be used to disenfranchise eligible voters.
Why Don’t Diamondbacks Streak?
Inspiration. I very much enjoyed Jim McLennan’s The Arizona Diamondbacks Have Not Gone Streaking. I learned that the Diamondbacks have not won 7 consecutive games since 7 September 2017 (a very long time). And I tip my hat to JWinMesa for his comment to that article. A summary is that as measured by Total Streak […]
Endometriosis can go undiagnosed for years. Here's what to know
Endometriosis afflicts 1 in 10 women worldwide, but diagnosing the painful disease is a challenge. New tests being used in other countries could help.
“Full House” star Lori Loughlin files for divorce from Mossimo Giannulli after nearly 30 years of marriage
Loughlin and Giannulli both served prison time after pleading guilty in the college admissions scandal.
Why Lewis Dunk Is STILL Brighton's Most Underrated Player
The veteran skipper remains the common denominator in Brighton’s success, transforming raw defensive partners into stars while proving he is the timeless heartbeat of the Seagulls’ backline.
After Causing Delays for 9/11 Health Claims, Social Security Pledges to Do Its Job
Lawyers say the Social Security Administration has for months not provided basic data to complete compensation claims for those sick and dying after exposure to debris from the Sept. 11 attacks.
From science to screen time: 4 key takeaways from the latest PISA results
Amid reading declines that included a 14-point drop for the U.S., researchers are looking at the role digital learning and AI may have played.
Apple Event Tomorrow: iPhone 18 Pro and iPhone Ultra Cheat Sheet
Apple's biggest event of the year is almost here, and all eyes are on Cupertino. With the first foldable iPhone expected to headline Apple's "Surprise and Shine" event on Wednesday, September 9, at 10:00 a.m. Pacific Time, the rumor mill has been running full throttle, fuelled by the biggest single design change in the life of the iPhone.
Pritzker, Eyeing 2028, to Help Midterm Democrats With a $20 Million Group
JB Pritzker, the billionaire governor of Illinois, is continuing to expand his national footprint, this time by using a new group to target Republicans in battleground races.
Gov. Gavin Newsom's former chief of staff seeks to delay sentencing because of health issues
Dana Williamson, Newsom's onetime chief of staff, is seeking to delay her sentencing date for political corruption because of health issues, according to documents.
Harvard, MIT scholars head north as Carney offers millions
Canada is investing $362 million to lure 64 top global scholars, including dozens from Harvard, MIT and other elite U.S. universities, to advance research in health and artificial intelligence.
Trade war shock: Tariffs push Canadian small businesses to the brink
The economic pain that Canadian Prime Minister Mark Carney warned would come from a trade war is now a harsh reality for some small businesses that export to the US.
Honda Postpones Big Upgrades to 2027
The Japanese brand's trackside boss confirms no significant evolution this year. The AMR26's lack of top speed showed at Monza, with Alonso and Stroll posting the weekend's worst times.
Valheim 1.0 Launches After 5 Years in Early Access
Valheim launched into Steam Early Access in February 2021 and quickly garnered attention, launching with over 500,000 peak concurrent players on Steam and still counting over 20,000 daily concurrent players at the time of writing. Now, over five years after the Early Access launch, the open-world...
15 best TV shows to watch this fall
From a reimagining of a Stephen King classic to the return of a critically acclaimed crime drama, here are 16 shows to be excited about this fall.
LMH Health, KU and others form Astra Health with goals of reducing costs, expanding access
LMH Health, the KU Health System and three other Kansas health systems have joined forces to form Astra Health, a collaboration aiming to improve care, reduce costs and better serve rural communities.
How to Watch Tyler Perry's Assisted Living Season 7 Premiere
Watch Tyler Perry's Assisted Living live with TV channel, start time and streaming info. Stream Season 7 Premiere on Fubo — no cable required.
After the theft of 3 Renoir paintings from a French museum, here’s a look at other famous heists
Thieves have hit the Renoir Museum on the French Riviera and made off with four valuable paintings by the French impressionist master.
Eagles legend Brandon Graham announces retirement after 16 seasons
Brandon Graham announced his retirement for a second time, ending a franchise-record 16-season career spent entirely with the Philadelphia Eagles
Telluride 2026: The 6 best movies we saw at the film festival
Some major Oscar contenders were forged, notably Andrew Scott and Julianne Moore, as the exclusive Colorado film showcase pulled off a successful edition.
Clive Davis’ $35 million art trove, including Warhol and Hockney, heads to auction
The works owned by Clive Davis includes David Hockney's portrait of Andy Warhol and Warhol's portrait of Aretha Franklin, among other works collectively estimated to fetch more than $35 million.
Jaguars’ Antonio Johnson could solidify elite secondary
The Jaguars’ defense was undoubtedly one of the NFL’s best last season, but it’s time to prove they can do it again.
Wisconsin workers see higher wages, fewer jobs, increased disparities
The median wage for Wisconsin workers is $26.17 according to a “State of Working Wisconsin” report. Job growth is slowing as racial disparities trend up.
29 More Days Isn't a Business Plan (Opinion)
The one-month reprieve on the impending ban on many hemp products doesn't give small businesses enough time to make the decisions required to keep their companies running. Dylan Raap, CEO and founder of cannabis and hemp business Upstate Elevator, asks Congress to ‘tell us what the rules are and give us enough runway to live by them.’
How to watch the 2026 Emmys: Start time, where to stream, full nominee list and more
Are you ready for the 78th Primetime Emmy Awards?
Clive Davis’ art collection heads to Christie’s auction
Clive Davis’ largely unseen art collection, featuring works by David Hockney and Andy Warhol, could fetch more than $35 million at Christie’s.
Scientists find a huge 10-sided pattern in the clouds over Saturn's south pole
Scientists have discovered an enormous 10-sided wave pattern in the icy ammonia clouds over Saturn's south pole
AstraZeneca’s breast cancer pill gets approval from the FDA
AstraZeneca Plc’s breast cancer pill was approved by the U.S.
Lego announces its third Legend of Zelda set, this time featuring Link on Epona
The set will be released next year and is once again based on Ocarina of Time…
Eagles beloved two-time Super Bowl champion announces retirement
This longtime Eagles DL is retiring from the NFL.
NFL Announces Halftime Act for Detroit Lions Munich Game
The NFL has announced Cage The Elephant as the halftime headliner for the Detroit Lions’ Nov. 15 game against the New England Patriots in Munich.
The New York Times: A new editor for Politics
Ben Shpigel, who’s guided fast-breaking coverage on Live and Sports, will help elevate real-time political coverage at The New York Times.
‘Democrats Are Behind’: PAC Wants Party to Catch Up on A.I.
The group is starting with more than $10 million and says it intends to support midterm House candidates in swing states.
ON THE MARK: Acclaimed blues band Blueprints returns to Madison Hall
You don’t need an intricate plan to build a fun time this weekend.
Norman Gelman, Longtime Montgomery County Political Activist, Dies at 97
Norman Ira Gelman, a longtime Montgomery County political activist, policy analyst, writer and Jewish community leader who spent decades involved in public affairs in the Washington area, died July 20.
Roundup: Energy employment / Small business confidence / Maritime woes
Jobs in transition: Energy sector employment fell about 1% nationwide and in Louisiana from 2024 to 2025, with Louisiana losing 1,131 jobs to reach roughly 160,000 workers. The decline was driven largely by automation, policy changes affecting renewable energy, and shifting economics, while traditional energy industries such as coal and nuclear saw job growth. Despite […]
Galaxy Z Fold 8 display corners can bend inward on purpose, Samsung says [Gallery]
The internet is mad. Shocking statement, I know, but this time it’s about a perceived quality control issue on the...
AZ's R&D chief Barr touts internal 'science success story' after IL-33 antibody's stellar showing in COPD
With a detailed data drop that AstraZeneca’s R&D chief described as an internal “science success story,” the British Big Pharma has secured an FDA priority review for what it believes could become a flagship biologic in chronic obstructive pulmonary disease (COPD). In detailed results from the late-stage Oberon and Titania trials—first teased in March and detailed in full at the European Respiratory Society Congress in Barcelona this week—the drugmaker laid out the extent of its IL-33 inhibitor’s potential to reduce moderate and severe exacerbations in a wide range of COPD patients still struggling with those “lung attacks,” as AstraZeneca’s Sharon Barr, Ph.D., called them, despite using standard-care inhaled therapy. In the headline results, a 300 mg dose of tozorakimab given once every four weeks curbed those moderate and severe exacerbations in the studies’ primary population of former smokers by 29% in the Oberon study and 34% in Titania. In the overall population of both current and former smokers, these reductions were 30% and 29%, respectively, versus placebo and inhaled standard of care. The benefits also extended to clinically meaningful exacerbation reductions in all prespecified patient subgroups and specifically turned up promising signals in patients across a range of blood eosinophil counts, with Barr telling Fierce that “it’s the details that make this even more exciting than the high-level results that we’ve already shared.” In fact, during AZ’s tozorakimab poster presentation at the ERS 2026 Congress this past weekend, attendees were so enamored by the data that event organizers had to encourage people to clear the room and look at the other presentations on offer, Barr said in an interview. “I think it really speaks to the fact that there is a lot of buzz around these data because the entire respiratory community has been so desperate for new therapies for these patients,” she explained. The respiratory disease continues to represent a “staggering unmet medical need,” Barr said, highlighting the COPD exacerbations that the Oberon and Titania studies homed in on, which she added carry a greater mortality risk than a heart attack. “When a patient has a severe exacerbation, only about half of them are still alive within three and a half years,” she pointed out. As for tozorakimab specifically, Barr christened the molecule “an AstraZeneca science success story,” harkening several years back to the point at which researchers began to explore IL-33 as a driver of respiratory disease, and COPD in particular. At the same time, “there was still so much that wasn’t understood,” she admitted, highlighting the insight that IL-33 signals through both ST2 and EGFR through the RAGE pathway, a discovery Barr attributed to AstraZeneca's own scientists. Understanding the need to tackle both pathways in COPD—and aware of competitor candidates in the hopper, including one that bound ST2—the company ultimately had to make some “courageous decisions,” Barr said. These included taking a prior COPD molecule offline and going back to the drawing board to reinvent its potential IL-33 label “to make sure that we had a molecule that could block signaling through both arms of the pathway, through both the reduced form and the oxidized form, knowing that we wouldn’t be first, but striving to be best.” “When we put [tozorakimab] into the clinic, we firmly believed that we had a differentiated molecule, and we saw the other molecules blocking just ST2 or partially blocking IL-33, unable to deliver two positive pivotal studies in COPD,” Barr explained. “We kept marching forward because we believed our molecule was differentiated, and now I think we have the clinical validation that supports that.” Ultimately, AstraZeneca finds itself on much better footing these days when it comes to potential biologic rivals to tozorakimab in COPD. Sanofi and Regeneron’s Dupixent, for instance, is approved to treat COPD exacerbations in patients with high eosinophil counts, but not low ones. Meanwhile, the future has become cloudier for other next-gen IL-33 candidates from Sanofi and Regeneron, as well as Roche, which have suffered trial flops in recent years. One other potential ingredient for AstraZeneca’s success in its duo of studies was that the company was “ambitious in the trial design, willing to look at an all-comers population,” Barr said, “and willing to enroll the most severe patients.” Prior studies for would-be biologics rivals in COPD “avoided enrolling” those patients, she pointed out. She also highlighted the Big Pharma’s painstaking design of exacerbations in its trial, which “gave us a very rigorous readout,” and pointed to “the extra effort and investment” the company put in to understand the effect of mucus plugs in patients. Barr described mucus production as a “key feature in disease diversity,” noting that mucus plugs—obstructing clumps of mucus that block patients’ airways—are associated with worse outcomes in COPD. In its data announcement, AstraZeneca noted that an integrated analysis of Oberon and Titania found tozorakimab “demonstrated a reduction in patients’ mucus plug score,” with the pharma claiming its biologic is the first to deliver such results in a broad COPD population. “So being able to reduce those mucus plugs, we expect, is an important part of driving benefit for patients who are living with COPD,” Barr said. Again touching on the breadth of the study populations, Barr added that tozorakimab “worked across all eosinophil levels in both current and former smokers across all levels of lung function,” which she suggested “really simplifies decision-making for clinicians, and it allows them to offer therapy to the broadest possible patient population.” In the highest patient eosinophil count group, tozorakimab helped chart a 43% reduction in exacerbation risk, which Barr stressed were “unprecedented data.” In the mid-level group, AZ’s drug delivered a 23% reduction and, in the lowest group, a 34% reduction in eosinophils, which Barr said suggests efficacy “in all patient subgroups.” As for AZ’s recent guidance upgrade on the medicine’s sales opportunity, the lift from a $3 billion to $5 billion range to $5 billion plus was informed by multiple factors, Barr said, including the fact that “in 2024, there were multiple competitors, and there aren’t anymore.” Additionally, “we know that this is a massive unmet medical need, and this is a really incredible set of data that we think will be very convincing to the clinical community,” Barr said. Looking ahead to a potential evolution of the COPD treatment landscape, Barr noted that most patients start treatment in the community with an option like a triple therapy, and for them, having an option like AstraZeneca’s inhaler Breztri will remain a “really important part” of that journey. But of the patients uncontrolled on triple therapy, which Barr described as “about half of them today,” just a “small fraction” are currently eligible for biologic therapy, which she emphasized AstraZeneca is working to change. Understanding that COPD is not a “one-size-fits-all” disease, AstraZeneca is also looking at its antibody drug Tezspire for patients with T2-driven disease, and the company continues to think about new mechanisms for tackling COPD through both systemic and inhaled drugs, Barr said.
Hong Kong students drop in global rankings for maths, science and literacy
City’s students drop out of global 10 in Pisa’s science section – the first time since Hong Kong joined international assessment.
The Legend of Zelda: Ocarina of Time remake gameplay finally revealed during 40th anniversary Nintendo Direct, and it looks… interesting
Gameplay has been released for The Legend of Zelda: Ocarina of Time remake during today's 40th anniversary series Nintendo Direct.
Spirit Halloween opens for season
Spirit Halloween has returned for another season -- this time in a new location.
Trump threatens Canadian jetmaker Bombardier
U.S. President Donald Trump has threatened to ban the sale of aircraft from Canada’s Bombardier unless it manufactures planes in the United States
The New York Times
Seven of Ukraine’s top 10 military contractors won new business despite open criminal investigations for fraud, failures to deliver on earlier deals or the arrest of chief executives for corruption,...
BUSINESS Katie Scheuber showcases their unique storytelling with Stay Tuned Productions
Almost 12 years ago, nonbinary lesbian Chicago documentary filmmaker and photographer Katie Scheuber created Katie Makes Films video, a production company to showcasing their love of visual storytelling, while still working as a social worker. In 2022, Scheuber’s wife Noemi Heras encouraged them to do the video work full time. Last year Scheuber created Stay Tuned […]
Penélope Cruz and Javier Bardem Say 'It's Impossible' Not to Talk Politics After Starring in Projects Like 'Bunker'
Penélope Cruz and Javier Bardem agree that "it's impossible" not to talk politics as actors when they're starring in timely stories
Winchester Health Department to provide School Flu Clinics for students
The following was submitted by the town of Winchester: Parents can register their children for School Flu Clinics now through Tuesday, Sept. 15 at 11:59 p.m.. You may select any open appointment time, but note that appointment times are not the actual time your student will be vaccinated.
Scott McTominay has successful heart surgery as return timeframe revealed
Napoli released a statement on Tuesday following McTominay’s heart procedure
California’s political hopefuls remain silent on state’s job losses, unemployment
Dan Walters Commentary: The aspirants for those positions are making all sorts of promises to win voters’ approval. But few, if any, have mentioned a slow-motion menace affecting a fundamental
Savannah Guthrie returns to “Today” after 2-week absence
Guthrie enjoyed some downtime at the close of summer.
A ‘Trumpapalooza’ in 2026. Reagan in 1984. Two GOP conventions in Dallas, but times have changed
Dallas hosted the 1984 Republican National Convention and a GOP midterm convention is about to start. The city — and the politics — have changed a lot.
What Makes Guardant Health (GH) a Compelling Bet?
Artisan Partners, an investment management company, released its second-quarter 2026 investor letter for the “Artisan Mid Cap Fund”. The letter can be downloaded here. Global equities rebounded sharply in Q2 2026, recovering from March lows as resilient economic data, strong corporate earnings, and continued AI investment improved investor sentiment despite inflation concerns, delayed rate cuts, and […]
Apple’s new CEO John Ternus expected to debut foldable iPhone at event Wednesday
Apple will kick off a new era on Wednesday when CEO John Ternus takes the stage for the first time for the company’s annual iPhone launch event.
Kelly Ripa returns to ‘Live’ for first time in over 1 month after painful gum surgery
Kelly Ripa finally returned to ‘Live With Kelly and Mark’ for the first time in over a month, following an extended absence due to painful gum surgery.
Ashley St. Clair and Alex Gibney on AI and the dangers of Elon Musk
A new documentary about Elon Musk uses an AI avatar to simulate an interview with him, using real quotes.
How Merlin Entertainments is approaching GEO
The attractions business revamped its search strategy and grew its AI Overview visibility at six times the benchmark rate.
Academy Sports + Outdoors Announces Participation in Upcoming Investor Conference
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Six decades of politics (but little government)
The first aired episode of “Star Trek,” entitled “The Man Trap,” premiered on September 8, 1966 — 60 years ago today. I’m actually editing a political science fiction issue of The Forum right now, and it’s prompted to me think a lot about the ways that Trek deals with politics and government and what it’s offered us as commentary. The @smotus report is a reader-supported publication. To support this work, please become a paid subscriber. Subscribe The original TV series ran from 1966 to 1969. It had a loyal but modest following, but the audience grew substantially with the series in syndication for years after that. The franchise developed its first motion picture in 1979, followed by five sequels, and then a whole other series of films built around the “Next Generation” series that first aired in 1987. In recent decades, several more TV series have built up around it, including the current “Strange New Worlds,” now in its fourth season. Throughout the past six decades, the franchise has offered us a good many insights into US politics and international relations, although often disguised as science fiction yarns. The original series was largely a Cold War fable, with the United Federation of Planets (a stand-in for the US) perpetually at odds with the Klingon Empire (a stand-in for the USSR). The “Let That Be Your Last Battlefield” episode (1969) posited a planet divided into two races, largely indistinguishable to outsiders, but nonetheless constituting a brutal racial hierarchy. “Patterns of Force” (1968) showed a struggling planet where the leader had attempted to construct a benevolent dictatorship — literally Nazism without bigotry — and found that authoritarianism could not exist apart from hierarchy and oppression. (Relatedly, I’d put “Star Trek VI: The Undiscovered Country,” high on a list of dad films about the end of the Cold War, near “The Hunt for Red October.”) Get 20% off for 1 year Indeed, the original series itself was something of a political statement, with a multi-racial crew running the Enterprise, a diverse and largely peaceful Federation mostly free from want and oppression, and protected by Starfleet, an armed force whose scientific mission was at least as important as its military one. Famously, when Nichelle Nichols wanted to walk away from the role of Uhura on the original series, none other than Martin Luther King, Jr. met with her and urged her to remain on the show, discussing the importance of viewers seeing an intelligent Black woman as part of the command team three centuries hence. Later series in the Trek franchise offered a good deal of political commentary on their own, but probably none as explicitly and incisively as “Deep Space Nine,” which ran from 1993 to 1999. The episodes surrounding the Dominion War, especially the “In The Pale Moonlight” (1998), showed the compromises, sacrifices, and moral rot associated with winning even a just war — probably better than any series would until “Andor” (2022-25). In “Far Beyond The Stars” (1998), Captain Benjamin Sisko is somehow transplanted to the role of a science fiction writer in 1950s New York. The writer is frequently sidelined and his ideas stolen because publishers don’t want to credit a Black writer. Several series have depicted the secretive Section 31 — an unacknowledged black ops security force operating within Starfleet. These episodes often end up using Section 31 as a foil to show the dangers of a lawless group within a lawful society, even (especially) when that group posits itself as essential for everyone else’s freedom to continue. The current “Strange New Worlds” has played with a few political themes. I found the first two seasons of this show among the best that the Trek franchise has produced in decades, but this season and the last have really been struggling for ideas. Yet one interesting thread is the idea that the diplomatic and enlightened leadership style of Captain Christopher Pike will not work in all situations. “A Quality of Mercy” (2022), which I wrote about here, puts Pike in the middle of a battle with a Romulan vessel in an alternate timeline, and finds that Pike’s conciliatory style would actually make a lengthy and deadly war more likely, while a quick and more violent approach might have prevented the war. This season’s opener, “Valles Marineris,” shows a pre-lightspeed civilization locked in a war to the death with a neighboring planet. The idea of an alliance or a federation hasn’t even occurred to them — their ship’s commander is curious but doesn’t see it as an option. For a franchise as political as “Star Trek,” one thing we almost never see is the government. We get occasional glimpses of Starfleet’s council — mostly uniformed people at a rectangular table — but almost no sense of how the Federation is governed. Are there elections? Who is in the legislature? How much power does the president have? What kind of factional divisions do they wrestle with and how? The shows and films are pretty silent on this. We’ve seen a few military tribunals within Starfleet, but little about how civilians deal with crime and injustice. With recent years seeing some of the franchise’s more interesting plot lines and casts, it seems clear that Star Trek is still full of energy and ideas. Given the erosion of American democracy and the reshuffling of the international order, there’s no shortage of material for future shows to comment on. I’m not sure we should toast to 60 more years, but cheers to a show that continues to teach us about ourselves. Share
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