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LG TV shown capable of tracking user activity, even when offline
“It doesn’t cost a lot to store text forever.”...
Cowboys' Brian Schottenheimer gets surprise boost nobody saw coming
Dallas Cowboys head Brian Schottenheimer is going to love this projection.
Hailey Bieber poses nude, opens up about her Brazilian roots
Hailey Bieber is saying more and wearing less. The 29-year-old model posed nude on the cover of photographer Renell Medrano’s ICE magazine, appearing in "Vol.
Colts Part Ways With 29-Game Starter
Jaylon Jones did well to turn himself from a seventh-round pick into a consistent contributor the Indianapolis Colts. Those contributions didn’t end up being big enough, though. The Colts waived Jones on Tuesday. It was part of a three-pronged roster move that the Colts announced in an official press release like this: “The Indianapolis Colts […] The post Colts Part Ways With 29-Game Starter appeared first on HEAVY.
Unlocking Forest Diversity from Above: Fieldwork at Smithsonian’s BiodiversiTREE
Laying groundwork for using airborne remote sensing to better understand the characteristics of forest species diversity.
Lori Loughlin is divorcing Mossimo Giannulli after 30 years together
“Full House” star Lori Loughlin is formally ending her nearly 30-year marriage to fashion designer Mossimo Giannulli. The 62-year-old sitcom actor said the pair separated on Aug. 31, 2025, according
Local businesses brace for gigantic cargo moves starting next week
Locals anxiously waiting for superloads of heavy equipment — weighing up to 380 tons — to travel through their towns will have to hold on until next week. The first trip, on a giant, specialized truck, is expected to leave a dock in Gilpin’s Schenley section on Monday morning. Officials
TRUE Community Credit Union Highlights Business Services
Airdate: September 8th, 2026 TRUE Community Credit Union Highlights Business ServicesSeptember 8, 2026Purple Rose Theatre to Present World Premiere by Devin ScillianSeptember 8, 2026Dr. Grant Brown on Autumn Vaccine RecommendationsSeptember 8, 2026Silver Maples of Chelsea Hosting Jackson Art Association Member ShowcaseSeptember 8, 2026Jackson County Genealogical Society Hosting Cemetery TourSeptember 8, 2026Otterbein SeniorLife Jackson Dedication &…
Southern Union names Pike dean of health sciences
CONTRIBUTED BY SUSCC OPELIKA — Southern Union State Community College has named Dr. Richard Pike as dean of health sciences. Pike assumed the position Sept. 1 following the retirement of Dean Rhonda Davis. A graduate of Southern Union, Pike earned an associate in science degree and his emergency medical technician certification from the college. He […]
Why Are So Many Parked Cars Catching On Fire?
When I was about nine years old, I was riding in the back of my family’s old ’68 Volkswagen Beetle when the car started to lose power and slow down. My mom, who was driving at the time, began to pull over to the side of the road, and at that moment I looked behind […]
US targets multiple Iranian tankers near Kharg Island
The US targeted multiple Iranian tankers near Kharg Island in the Strait of Hormuz on Tuesday, according to two US officials.
Ohio politicians keep promise to rebuke Les Wexner by donating $200K in campaign contributions
Freedom a la Cart, a downtown Columbus cafe that employs sex trafficking survivors, was one of several organizations that politicians donated to this year.
REPORT: Man had history of mental health disorders before stabbing fiancée at East Haven apartment
EAST HAVEN, Conn. (WTNH) — An incident report obtained by News 8 on Tuesday reveals that the suspect in an East Haven stabbing had a history of mental health disorders before allegedly assaulting h…
New Australian Open Head Suggests Shortening Grand Slam Matches
Andrew Abdo took over for Craig Tilley last month.
Florida high school football coach fired after just three games
Dan Nieboer was hired away from Jason Witten's Liberty Christian staff in Texas to lead Lely (FL). After an 0-3 start, he's been let go.
'We're resilient': Maine businesses brace for new round of Canadian tariffs
Canada is officially striking back in the trade war with the United States.
North Carolina MCO Alliance Health Taps Cortica to Rein in Autism Spending, Improve Outcomes
Ready to dive into what's shaping autism therapy-payer relations? Be a part of the Autism Investor Summit East this November 9–10. Get your tickets here.
Catch 22: Californians can't afford health insurance but face fines if they drop it
For one Californian, the state subsidy contributed $1 a month to her $600 premium. She considered dropping coverage but faced a $1,600 penalty.
988: September 8 marks nationwide awareness campaign for mental health crisis lifeline
Georgians are being asked to tell a friend about 988 as part of a nationwide campaign marking September 8.
Moment of Science: Abundant oxygen not enough to explain massive ancient insects, new study suggests
Unlocking answers about giant ancient insects! Here's why an abundance of oxygen 300 million years ago may not explain why some animals got so gigantic after all.
Exclusive: Two of gaming’s biggest names are making a big investment in gaming’s future
The first thing to know about the Nova Games Foundation is that it isn’t about The Game Awards. And it’s not about PlayStation. The ambitious new grant program is the brainchild of Geoff Keighley and Mark Cerny. Keighley is the host of The Game Awards, Summer Game Fest and Opening Night Live. Cerny is a game designer of some 45 years and the lead architect for the PlayStation 4 and 5. But this new thing, which they’re revealing through Game File, isn’t about their day jobs. It’s an unaffiliated, standalone philanthropic project. It’s a bet on the artistic future of video games and a way, they tell me, to give back. “I’m nearing the end of my career,” Cerny recently told me over email. “I’m not done yet, but paying it forward—in the best way possible—is very much on my mind these days,” The Nova Games Foundation is a university-affiliated fellowship program, intended to offer six-figure grants to 20 young game designers each year, potentially for decades to come. It will offer no-strings-attached funding along with mentorship from games industry leaders, a combination intended to aid the development of groundbreaking new games, Cerny and Keighley told me. Nova will begin accepting applications in December, from class of 2026 and 2027 students from 13 affiliated gaming programs at universities in eight countries. The schools working with Nova include the New York University and the University of Southern California in the U.S., along with Abertay University in Scotland, Cnam-Enjmin in France, TH Köln in Germany, and the Royal Melbourne Institute of Technology in Australia, Cerny and Keighley said. The plan: $100,000 per recipient, with about a quarter of Nova fellows eligible for up to $500,000 more for projects that are shaping up particularly well. Payments will be delivered based on development milestones, and recipients will own their games. Nova will help promote the work, and developers will be free to pursue the publishers and platforms of their choice. Nova can help introduce fellows to publishers, but won’t take a cut. “I’ve always wanted to give back, but given my role in the industry, I’ve never felt it appropriate to commercially invest in games,” Keighley told Game File. “I’ve never owned stock in a game company or taken a financial stake in a game. Nova is philanthropy: we aren’t taking equity or looking to recoup the grants. The return we’re hoping for is creative—helping new voices make games and find their footing. “Mark and I have each made multi-million-dollar donations to establish the foundation, and we intend to keep contributing. We hope others will join us.” Cerny and Keighley have already hired an executive director, John Maconga, and a head of grants, recent Game Developers Conference director Ashley Corrigan, to help launch the effort. They’re working to recruit game industry leaders to join the effort. Keighley says “dozens of leading game directors have already expressed interest in contributing their time.” To name one, they’ve already gotten Josef Fares, lead designer from It Takes Two and Spit Fiction studio Hazelight on board with a donation and pledge to help out. “I’m proud to support Nova because it gives the next generation of creators the freedom to explore their creativity and hopefully bring their unique visions to life,” Fares told Game File. A plan forged from a friendship Keighley and Cerny have known each other a long time. It’s been so long, Cerny isn’t even sure exactly when they met. “We travel in much the same circles and I’m sure first intersected in the 90s or early 2000s,“ Cerny said. Keighley thinks it might have been during his stint writing a column about the mid-’90s console 3DO for a gaming magazine while Cerny was working on games with Crystal Dynamics or on Way of the Warrior with Naughty Dog. They became genuine friends about a 10 years ago, Keighley said, as they bonded over a shared love of games and a hope to improve the industry. “About a decade ago, we started having dinner a few times a year in LA,” Keighley said. “Just to catch up on life and the industry. Those conversations continued over Zoom during COVID. Nova grew out of that friendship and a question we kept coming back to: ‘What could we do to help the next generation of game directors get started?’” Keighley credits Cerny with the idea to figure out a way to put their money and time back into the industry. At one of those dinners, Keighley proposed the idea of a fellowship program. He’d recalled applying for a Rhodes Scholarship when he was younger. “Spoiler: I didn’t get it,” he said. He’d admired the MacArthur Foundation’s so-called “genius grants.” He liked these kinds of programs that recognized people’s talents and gave them the financial boost and the freedom to realize their potential. With Cerny, he had pondered what a game industry version of that could be. Keighley liked the idea of centering the fellowship on students, drawing inspiration from the accomplishments of Jenova Chen, the USC game design graduate who went on to lead the creation of gently moving, ambitious games such as Flower and Journey. Keighley also thought it could be useful to help promising graduates bridge the transition from student to professional. “Joining an established studio isn’t always possible—especially in today’s market—and even then, it isn’t the right path for everyone,” Keighley said. A fellowship, he realized, could give “graduates the time, resources and guidance to pursue a game of their own and not worry about the commercial viability.” As the idea took shape, Cerny also saw an opportunity to enable more games of a certain type: “The target with the grants is games as an artistic medium,” Cerny told me. “We like to say games with ‘artistic, literary and societal value.’” He added: “I’m a pretty big gamer myself, though I tend to gravitate towards the smaller and more unique or artistic titles, games like Neva, Abzu, Gorogoa, Stray or Outer Wilds. I was just playing and Roger on a flight to Japan, and was getting misty eyed to a degree that I was concerned that a flight attendant would ask me if I was OK. “So one fun benefit here is the games that will come out of the Nova Games Foundation – I can’t wait to play them myself.” Cerny believes it will also be useful for Nova fellows to hone their craft and team leadership skills. “We are looking for the next generation of visionaries,” he said. “The trick is that they will also need to have the executive function necessary to drive a small project to completion.” Game File is a reader-supported publication. To receive new posts and support my reporting, please consider becoming a free or paid subscriber. Subscribe Going big with this Keighley and Cerny may have started Nova and may be the ones primarily backing it right now, but they’re dreaming of something that goes beyond them. “Mark and I may have helped get it started, but one of our measures of success is that Nova grows into something the entire games industry feels a sense of ownership in,” Keighley said. “Our ambition is to build a lasting endowment supported by people and companies across the industry, and an equally broad community of creators willing to give their time and experience to the next generation.” The industry has a lot of knowledge that it can pass to the next generation, Keighley said: “Nova can hopefully become a way to connect that generosity with talented young creators at the moment when it can make the biggest difference.” Cerny, who told me he believes Nova can mature “over the next 10 or 20 years,” sees an opportunity to give generations of game makers momentum. “The industry has changed immeasurably since I started in games in 1982,” he said. “These graduates have talent, training and tools that outclass what we had back in the day by an astonishing amount. But they face a tough road ahead getting traction in the industry, and many could benefit from our support. We want to be there to give it to them.” “There’s a personal side to this, too,” Keighley said. “I don’t have children, and I’ve spent a lot of time thinking about what I can do for future generations. Games have been my entire career. I’ve been incredibly fortunate, and helping someone else build a life in this industry feels like a meaningful way to give back.” Cerny’s oeuvre dates back to Marble Madness and Sonic the Hedgehog 2. He has stood on stage multiple times to reveal the future of PlayStation hardware. He’s been an executive producer for a string of modern PlayStation classics such as The Last Guardian and Marvel’s Spider-Man. Nevertheless, of Nova, he said, “It’s certainly not like anything I’ve done before.” Nova Foundation applications will be due in December and the first wave of fellows will be announced in March 2027. A full list of participating universities and steps students and recent graduates can take to apply to become a Nova Fellow is forthcoming.
Post-World War II economy spurs small-business growth.
This week’s TALE sought out a guest author, Richard “Dick” Coyle, to share the history of one of our long-standing businesses in an article titled “C & C Oil Company: A brief history of 60 years in business.” C & C Oil Company began in 1938 as a simple one-pump service station in Bluffton, Indiana.
Funding cuts are forcing dozens of health clinics in Sudan to close, aid groups warn
CAIRO (AP) — An additional three dozen health facilities serving more than 400,000 people in Sudan are closing this year due to global aid cuts, worsening a dire humanitarian situation in a country torn by more than three years of war, aid groups said Tuesday.
Google Cloud Boss Makes Bold Claim About AI Chip Business
In a boost for Google stock, cloud computing chief Thomas Kurian says AI chip business is more than twice the size of its closest rival.
Cannibalism returned to the menu multiple times in Neolithic Europe
Bones collected from three caves in Spain reveal how cannibalism came back over thousands of years.
OpenAI's big math breakthrough claim sparks drama
The math community is heated over questions about credit and AI training data after a mathematician's allegations against OpenAI went viral.
Aspen School District renews membership with Valley Health Alliance
Valley Health Alliance announced today that the Aspen School District has renewed its membership, marking a significant milestone for both organizations.
Artist creates pop art paintings for charity
Quiet conversation intermixed with smooth jazz piano at Asbury United Methodist Church on Friday evening, the old sanctuary providing shelter from the pounding rain for the art enthusiasts gathered within.
Louisiana’s marine research collaboration becomes a political battleground
A select group of Louisiana higher ed leaders are discussing what to do with the state's marine research consortium
Allegri counts on European 'motivation and adrenaline' for Napoli
Coach Massimiliano Allegri is hoping the arrival of Champions League football can help put Napoli on the right track after back-to-back defeats in Serie A. Victory on the opening day against Genoa has been undermined by successive defeats at the hands of Como and Inter Milan, leaving new boss Allegri looking for a reset when his side welcome Arsenal to Stadio Diego Armando Maradona on Wednesday evening.
Doctors Without Borders warns that funding cuts are forcing health clinics to close
Aid groups say three dozen health facilities in Sudan are closing this year due to global aid cuts. This worsens an already dire humanitarian situation in a country torn by more than three years of war.
Judi Dench’s Oscar doesn’t have her name on it: ‘Could be anyone’s’
Sir Ian McKellen, meanwhile, never got his Golden Globe engraved for a hilarious reason.
US issues sweeping sanctions against Iranian airlines, foreign businesses
The Trump administration on Tuesday announced new sanctions against all of Iran’s airlines and nearly a dozen foreign companies doing business with Iran’s Mahan Air, which had earlier been sanction…
“Full House” star Lori Loughlin files for divorce from Mossimo Giannulli after nearly 30 years of marriage
Loughlin and Giannulli both served prison time after pleading guilty in the college admissions scandal.
Lori Loughlin files for divorce from Mossimo Giannulli after nearly 30 years of marriage
Lori Loughlin filed for divorce from Mossimo Giannulli after nearly 30 years of marriage.
This Russian River Home on the Market Was Built for Entertainment
Built in 1994 and rooted in traditional style, the home includes a pool, outdoor kitchen, island-style bar, wine cellar and vineyard.
Booster group pushes to keep Downtown Pittsburgh businesses viable
The Pittsburgh Downtown Partnership has sought to bring more small businesses into the Golden Triangle in recent years — and now it’s launching a concerted effort to keep them there. Dubbed Business Boost, the initiative is meant to support small businesses and ensure they can last Downtown long-term, Pittsburgh Downtown
Louisiana contestant wins first runner-up in Miss America, 'Words that will never seem real.'
After reaching the final five, the current Miss Louisiana came up just shy of the win, but grateful for the experience nonetheless.
Scientists Are Still Trying To Understand How the Moon Formed
The Earth and the Moon have nearly identical isotopic compositions, and the Giant Impact Hypothesis strives to explain this. New research into the ancient impact shows how the temperature of both worlds, and how it affects the strength of the materials involved in the collision, shaped the outcome, including the isotopic compositions.
Smithsonian chief Lonnie Bunch to retire following clash with Trump admin
Bunch said in a news release Tuesday that he was departing the position he had held since 2019 "with very mixed emotions and heartfelt gratitude"
Smithsonian chief Lonnie Bunch to retire following clash with Trump admin
Bunch said in a news release Tuesday that he was departing the position he had held since 2019 "with very mixed emotions and heartfelt gratitude"
Smithsonian chief Lonnie Bunch to retire following clash with Trump admin
Bunch said in a news release Tuesday that he was departing the position he had held since 2019 "with very mixed emotions and heartfelt gratitude"
Trade war shock: Tariffs push Canadian small businesses to the brink
The economic pain that Canadian Prime Minister Mark Carney warned would come from a trade war is now a harsh reality for some small businesses that export to the US.
Lonnie Bunch to retire from Smithsonian leadership following Trump administration clash
Bunch is going to retire from Smithsonian Institution leadership following an ideological clash.
There are no More Excuses for Thunder’s Chet Holmgren
The All-Star center has shed his prospect status, leaving Oklahoma City’s championship hopes resting on his ability to transform flashes of brilliance into nightly, physical dominance.
Devers Records Giants First 35/35 Season Since 2002
Rafael Devers joins Jeff Kent in the San Francisco Giants franchise record books, leveraging an explosive September power surge to make up for the team's horrific season.
Green Sports Alliance Names Jeff Pacini as New Executive Director
/PRNewswire/ -- Today, the Green Sports Alliance announced the appointment of Jeff Pacini as its new Executive Director. In this role, Pacini will steer the...
Arsenal is watching back to back Champions League winner
Arsenal continue to eye top players who can improve their squad, and several names are on their radar, with Willian Pacho now emerging as one of the stars they want to sign. The Ecuadorian defender ha...
Greg Schiano Announces AJ Surace Will Start vs. Boston College
Surace will make his first career start on Friday night.
Smithsonian secretary Lonnie Bunch is leaving amid fights with Trump
Bunch, the first African American and first historian to lead the institution, said he has ‘mixed emotions’ about departing.
Telluride 2026: The 6 best movies we saw at the film festival
Some major Oscar contenders were forged, notably Andrew Scott and Julianne Moore, as the exclusive Colorado film showcase pulled off a successful edition.
AMP Sports Launches The Dark Side Podcast with Seattle Seahawks Super Bowl Champions Derick Hall and Byron Murphy II
SEATTLE – September 8, 2026 –Sinclair’s AMP Sports today announced the launch of The Dark Side, a new podcast featuring Seattle Seahawks Super Bowl champions Derick Hall and Byron Murphy II, alongside KOMO News Sports Director Niko Tamurian. Each week, The Dark Side will go beyond traditional game analysis, with Hall and Murphy offering a...
Are rich people really worse behaved? Here’s the science
Who’s more likely to steal sweets from a child? According to science, it’s the rich. A study seemingly confirming our suspicions about the moral behaviour of the wealthy was one of the winners of the 2026 Ig Nobel prizes, which honour research that makes you laugh and then think. Science editor Ian Sample tells Madeleine Finlay what the researchers think could be behind the phenomenon, and they explore some of the other awards, including one for a surprising quality we look for in our friends and another for a biomechanical definition of kissing
Cincinnati's Week 4 high school football schedule
Cincinnati Week 4 high school football games include Wyoming at Indian Hill, La Salle at Elder and Boyle County at Highlands.
Wisconsin workers see higher wages, fewer jobs, increased disparities
The median wage for Wisconsin workers is $26.17 according to a “State of Working Wisconsin” report. Job growth is slowing as racial disparities trend up.
Smithsonian head Lonnie Bunch to retire amid Trump administration effort to reshape institution
Lonnie Bunch III said Tuesday that he will retire as the head of the Smithsonian Institution, a role that placed him at the center of President Donald Trump’s efforts to reshape the world’s largest museum organization.
Chinese giants Xiaomi, Huawei race to get ahead of Apple’s rumored foldable iPhone
Xiaomi and Huawei launched new foldables ahead of Apple’s event, where the company is rumored to unveil its first foldable iPhone.
Dan Campbell Reveals Detroit Lions Guard Plan for Week 1
Dan Campbell is keeping Detroit's left guard competition alive entering Week 1. Christian Mahogany and Ben Bartch will split first-team practice reps, and both could see action against New Orleans.
Meta Removes Iran-Linked Network That Faked American Personas to Sway US Political Debate
The Combat Antisemitism Movement (CAM) welcomes Meta’s recent removal of an Iranian regime-linked network that disguised its origins while seeking to influence American political discourse. Meta disclosed the takedown on Aug. 27 in its H2 2026 Adversarial Threat Report. The network consisted of four Facebook accounts and 31 Instagram accounts linked to actors based in […]
Liverpool’s hunt for a new sporting director: Julian Ward and the standout internal options
FSG president Mike Gordon is leading the search for Richard Hughes' replacement, with both internal and external candidates being considered
Here’s Samsung’s Advice for Apple and Its Upcoming Folding iPhone
The competition is “absolutely welcome” by the pioneering Korean giant, but Samsung warns that the device’s “weight” is crucial.
Apple to Introduce All-New 'Readiness' App Tomorrow
Apple plans to announce an all-new "Readiness" app during its "Surprise and Shine" event this Wednesday, according to Bloomberg's Mark Gurman. In a social media post today, Gurman said the "Readiness" app will be a "variant" of the existing Vitals app on the Apple Watch. "The idea is to better compete with software from Whoop and Oura," he said.
New-to-science Amazon frog stands out for its slow ‘lazy’ song
Scientists recently described a new species of a tiny brown frog found in the Amazonian floodplain forests of Ecuador and northwestern Brazil. It looks nearly identical to related species but its slow, widely spaced out call sets it apart, researchers note in a study. “I’ve had to get into arguments because people said the frog […]
Egyptian TV presenter Sarah Khalifa sentenced to death in drug case
Egyptian TV presenter Sarah Khalifa has been sentenced to death for an alleged drug trafficking scheme.
Lori Loughlin files for divorce from husband Mossimo Giannulli
Lori Loughlin and Mossimo Giannulli are officially going their separate ways.
Lori Loughlin, husband Mossimo Giannulli to divorce after 30 years
Lori Loughlin and Mossimo Giannulli are officially going their separate ways. The "Full House" alum, 62, filed for divorce from her husband of nearly 30 years on Tuesday, Sept. 8,
Moment of Science: Abundant oxygen not enough to explain massive ancient insects, new study suggests
Unlocking answers about giant ancient insects! Here's why an abundance of oxygen 300 million years ago may not explain why some animals got so gigantic after all.
The shift in British policy on Israel is palpable
But progress could be threatened if there is a new more diplomatic government in Israel.
Prairie Meadows awards $275,000 to WesleyLife
Prairie Meadows has awarded $275,000 to the WesleyLife Foundation to support three of the organization’s initiatives. The grants include a $200,000 Legacy Grant supporting the $49.5 million redevelopment of The Village, a WesleyLife community in Indianola; $65,000 for WesleyLife Meals on Wheels; and $10,000 for WesleyLife Hospice. WesleyLife broke ground in 2025 on the redevelopment…
Former Kane Realty COO launches AI-powered real estate consulting firm
Bonner Gaylord and David Shaner co-founded Grounded Intelligence to help Triangle commercial real estate firms implement AI tools for competitive advantage.
In 12 years, Triangle man missed only 1 health insurance payment. He lost coverage
A mistake setting up autopay proved costly for this Morrisville family. Here’s what happened — and how you can avoid it.
Deonte Banks' ex-coach: 'Everbody's gonna see' why Giants drafted him
Henry Baker, the former coach of New York Giants CB Deonte Banks, believes everyone is about to see why he was a first-round pick.
Louisiana concrete companies join forces to capitalize on construction boom
Two Louisiana concrete suppliers are joining forces with two out-of-state companies to pursue large-scale construction projects as billions of dollars in new industrial and technology investment move … Already an INSIDER? Sign in. Already an INSIDER? Sign in
Roundup: Energy employment / Small business confidence / Maritime woes
Jobs in transition: Energy sector employment fell about 1% nationwide and in Louisiana from 2024 to 2025, with Louisiana losing 1,131 jobs to reach roughly 160,000 workers. The decline was driven largely by automation, policy changes affecting renewable energy, and shifting economics, while traditional energy industries such as coal and nuclear saw job growth. Despite […]
AZ's R&D chief Barr touts internal 'science success story' after IL-33 antibody's stellar showing in COPD
With a detailed data drop that AstraZeneca’s R&D chief described as an internal “science success story,” the British Big Pharma has secured an FDA priority review for what it believes could become a flagship biologic in chronic obstructive pulmonary disease (COPD). In detailed results from the late-stage Oberon and Titania trials—first teased in March and detailed in full at the European Respiratory Society Congress in Barcelona this week—the drugmaker laid out the extent of its IL-33 inhibitor’s potential to reduce moderate and severe exacerbations in a wide range of COPD patients still struggling with those “lung attacks,” as AstraZeneca’s Sharon Barr, Ph.D., called them, despite using standard-care inhaled therapy. In the headline results, a 300 mg dose of tozorakimab given once every four weeks curbed those moderate and severe exacerbations in the studies’ primary population of former smokers by 29% in the Oberon study and 34% in Titania. In the overall population of both current and former smokers, these reductions were 30% and 29%, respectively, versus placebo and inhaled standard of care. The benefits also extended to clinically meaningful exacerbation reductions in all prespecified patient subgroups and specifically turned up promising signals in patients across a range of blood eosinophil counts, with Barr telling Fierce that “it’s the details that make this even more exciting than the high-level results that we’ve already shared.” In fact, during AZ’s tozorakimab poster presentation at the ERS 2026 Congress this past weekend, attendees were so enamored by the data that event organizers had to encourage people to clear the room and look at the other presentations on offer, Barr said in an interview. “I think it really speaks to the fact that there is a lot of buzz around these data because the entire respiratory community has been so desperate for new therapies for these patients,” she explained. The respiratory disease continues to represent a “staggering unmet medical need,” Barr said, highlighting the COPD exacerbations that the Oberon and Titania studies homed in on, which she added carry a greater mortality risk than a heart attack. “When a patient has a severe exacerbation, only about half of them are still alive within three and a half years,” she pointed out. As for tozorakimab specifically, Barr christened the molecule “an AstraZeneca science success story,” harkening several years back to the point at which researchers began to explore IL-33 as a driver of respiratory disease, and COPD in particular. At the same time, “there was still so much that wasn’t understood,” she admitted, highlighting the insight that IL-33 signals through both ST2 and EGFR through the RAGE pathway, a discovery Barr attributed to AstraZeneca's own scientists. Understanding the need to tackle both pathways in COPD—and aware of competitor candidates in the hopper, including one that bound ST2—the company ultimately had to make some “courageous decisions,” Barr said. These included taking a prior COPD molecule offline and going back to the drawing board to reinvent its potential IL-33 label “to make sure that we had a molecule that could block signaling through both arms of the pathway, through both the reduced form and the oxidized form, knowing that we wouldn’t be first, but striving to be best.” “When we put [tozorakimab] into the clinic, we firmly believed that we had a differentiated molecule, and we saw the other molecules blocking just ST2 or partially blocking IL-33, unable to deliver two positive pivotal studies in COPD,” Barr explained. “We kept marching forward because we believed our molecule was differentiated, and now I think we have the clinical validation that supports that.” Ultimately, AstraZeneca finds itself on much better footing these days when it comes to potential biologic rivals to tozorakimab in COPD. Sanofi and Regeneron’s Dupixent, for instance, is approved to treat COPD exacerbations in patients with high eosinophil counts, but not low ones. Meanwhile, the future has become cloudier for other next-gen IL-33 candidates from Sanofi and Regeneron, as well as Roche, which have suffered trial flops in recent years. One other potential ingredient for AstraZeneca’s success in its duo of studies was that the company was “ambitious in the trial design, willing to look at an all-comers population,” Barr said, “and willing to enroll the most severe patients.” Prior studies for would-be biologics rivals in COPD “avoided enrolling” those patients, she pointed out. She also highlighted the Big Pharma’s painstaking design of exacerbations in its trial, which “gave us a very rigorous readout,” and pointed to “the extra effort and investment” the company put in to understand the effect of mucus plugs in patients. Barr described mucus production as a “key feature in disease diversity,” noting that mucus plugs—obstructing clumps of mucus that block patients’ airways—are associated with worse outcomes in COPD. In its data announcement, AstraZeneca noted that an integrated analysis of Oberon and Titania found tozorakimab “demonstrated a reduction in patients’ mucus plug score,” with the pharma claiming its biologic is the first to deliver such results in a broad COPD population. “So being able to reduce those mucus plugs, we expect, is an important part of driving benefit for patients who are living with COPD,” Barr said. Again touching on the breadth of the study populations, Barr added that tozorakimab “worked across all eosinophil levels in both current and former smokers across all levels of lung function,” which she suggested “really simplifies decision-making for clinicians, and it allows them to offer therapy to the broadest possible patient population.” In the highest patient eosinophil count group, tozorakimab helped chart a 43% reduction in exacerbation risk, which Barr stressed were “unprecedented data.” In the mid-level group, AZ’s drug delivered a 23% reduction and, in the lowest group, a 34% reduction in eosinophils, which Barr said suggests efficacy “in all patient subgroups.” As for AZ’s recent guidance upgrade on the medicine’s sales opportunity, the lift from a $3 billion to $5 billion range to $5 billion plus was informed by multiple factors, Barr said, including the fact that “in 2024, there were multiple competitors, and there aren’t anymore.” Additionally, “we know that this is a massive unmet medical need, and this is a really incredible set of data that we think will be very convincing to the clinical community,” Barr said. Looking ahead to a potential evolution of the COPD treatment landscape, Barr noted that most patients start treatment in the community with an option like a triple therapy, and for them, having an option like AstraZeneca’s inhaler Breztri will remain a “really important part” of that journey. But of the patients uncontrolled on triple therapy, which Barr described as “about half of them today,” just a “small fraction” are currently eligible for biologic therapy, which she emphasized AstraZeneca is working to change. Understanding that COPD is not a “one-size-fits-all” disease, AstraZeneca is also looking at its antibody drug Tezspire for patients with T2-driven disease, and the company continues to think about new mechanisms for tackling COPD through both systemic and inhaled drugs, Barr said.
Cleveland Armenian Festival returns to Richmond Heights this weekend
St. Gregory of Narek Armenian Church hosts the annual event Friday evening and all day Saturday.
Seiche Launches Marine Science And Technology Department With Three New Leaders
Seiche has established a Marine Science & Technology Department uniting marine mammal specialists, acousticians, and engineers under three new department heads. The move expands the company's scientific and technical capabilities across offshore wind, renewable energy, and broader marine environmental monitoring.
'Preposterous.' 6 Washingtonians on how the high cost of living affects their lives
KUOW spoke with six Washingtonians of varying income levels about how the region's high cost of living is affecting them — and potentially how they'll vote this fall.
Trump threatens Canadian jetmaker Bombardier
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Six decades of politics (but little government)
The first aired episode of “Star Trek,” entitled “The Man Trap,” premiered on September 8, 1966 — 60 years ago today. I’m actually editing a political science fiction issue of The Forum right now, and it’s prompted to me think a lot about the ways that Trek deals with politics and government and what it’s offered us as commentary. The @smotus report is a reader-supported publication. To support this work, please become a paid subscriber. Subscribe The original TV series ran from 1966 to 1969. It had a loyal but modest following, but the audience grew substantially with the series in syndication for years after that. The franchise developed its first motion picture in 1979, followed by five sequels, and then a whole other series of films built around the “Next Generation” series that first aired in 1987. In recent decades, several more TV series have built up around it, including the current “Strange New Worlds,” now in its fourth season. Throughout the past six decades, the franchise has offered us a good many insights into US politics and international relations, although often disguised as science fiction yarns. The original series was largely a Cold War fable, with the United Federation of Planets (a stand-in for the US) perpetually at odds with the Klingon Empire (a stand-in for the USSR). The “Let That Be Your Last Battlefield” episode (1969) posited a planet divided into two races, largely indistinguishable to outsiders, but nonetheless constituting a brutal racial hierarchy. “Patterns of Force” (1968) showed a struggling planet where the leader had attempted to construct a benevolent dictatorship — literally Nazism without bigotry — and found that authoritarianism could not exist apart from hierarchy and oppression. (Relatedly, I’d put “Star Trek VI: The Undiscovered Country,” high on a list of dad films about the end of the Cold War, near “The Hunt for Red October.”) Get 20% off for 1 year Indeed, the original series itself was something of a political statement, with a multi-racial crew running the Enterprise, a diverse and largely peaceful Federation mostly free from want and oppression, and protected by Starfleet, an armed force whose scientific mission was at least as important as its military one. Famously, when Nichelle Nichols wanted to walk away from the role of Uhura on the original series, none other than Martin Luther King, Jr. met with her and urged her to remain on the show, discussing the importance of viewers seeing an intelligent Black woman as part of the command team three centuries hence. Later series in the Trek franchise offered a good deal of political commentary on their own, but probably none as explicitly and incisively as “Deep Space Nine,” which ran from 1993 to 1999. The episodes surrounding the Dominion War, especially the “In The Pale Moonlight” (1998), showed the compromises, sacrifices, and moral rot associated with winning even a just war — probably better than any series would until “Andor” (2022-25). In “Far Beyond The Stars” (1998), Captain Benjamin Sisko is somehow transplanted to the role of a science fiction writer in 1950s New York. The writer is frequently sidelined and his ideas stolen because publishers don’t want to credit a Black writer. Several series have depicted the secretive Section 31 — an unacknowledged black ops security force operating within Starfleet. These episodes often end up using Section 31 as a foil to show the dangers of a lawless group within a lawful society, even (especially) when that group posits itself as essential for everyone else’s freedom to continue. The current “Strange New Worlds” has played with a few political themes. I found the first two seasons of this show among the best that the Trek franchise has produced in decades, but this season and the last have really been struggling for ideas. Yet one interesting thread is the idea that the diplomatic and enlightened leadership style of Captain Christopher Pike will not work in all situations. “A Quality of Mercy” (2022), which I wrote about here, puts Pike in the middle of a battle with a Romulan vessel in an alternate timeline, and finds that Pike’s conciliatory style would actually make a lengthy and deadly war more likely, while a quick and more violent approach might have prevented the war. This season’s opener, “Valles Marineris,” shows a pre-lightspeed civilization locked in a war to the death with a neighboring planet. The idea of an alliance or a federation hasn’t even occurred to them — their ship’s commander is curious but doesn’t see it as an option. For a franchise as political as “Star Trek,” one thing we almost never see is the government. We get occasional glimpses of Starfleet’s council — mostly uniformed people at a rectangular table — but almost no sense of how the Federation is governed. Are there elections? Who is in the legislature? How much power does the president have? What kind of factional divisions do they wrestle with and how? The shows and films are pretty silent on this. We’ve seen a few military tribunals within Starfleet, but little about how civilians deal with crime and injustice. With recent years seeing some of the franchise’s more interesting plot lines and casts, it seems clear that Star Trek is still full of energy and ideas. Given the erosion of American democracy and the reshuffling of the international order, there’s no shortage of material for future shows to comment on. I’m not sure we should toast to 60 more years, but cheers to a show that continues to teach us about ourselves. Share
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