SCROLL NEWS / DISCOVERY
Search headlines
Find the stories shaping the conversation.
Results for " Ugh " 16,692 found 🔀 AI-powered Shuffle
Penn State's Matt Campbell Needs to Go Back to Nittany Lions Old Ways
Being tough will get Penn State back to its roots.
CREO Brings AI, Health, National Defense Into Focus for Cybersecurity Awareness Month
The Center of Excellence in Cybersecurity Research, Education and Outreach is marking Cybersecurity Awareness Month with a speaker series that runs through Oct. 29.
St. Louis Cardinals Biggest 2027 Challenge? Managing Expectations
I have been a St. Louis Cardinals fan for more than five decades and I have lived through many different eras of losing seasons, championships and everything in between. I can’t recall any of them being more unclear about what the expectations should be for an upcoming season than the one that will hopefully begin […]
Jaylen Brown erupts in Sixers preseason debut
Jaylen Brown played in his first game with the Sixers, even though it was technically in the preseason.
The Xbox Elite Controller (Series 3) specs might've leaked — here's what's new (and the main thing you'll want to know remains unanswered)
Although I was unable to verify the sources (as they've been removed), users suggest that this leak is most likely legit. The Xbox Elite Controller Series 3 is likely imminent.
Relatives of Epstein victim appear in attack ad targeting Jeff Crank
Relatives of Virginia Giuffre, one of Jeffrey Epstein‘s most prominent victims, accuse U.S. Rep. Jeff Crank in a TV ad released Monday by his Democratic challenger of refusing to meet with them last year when they sought his assistance to force a vote to release federal files related to the convicted sex offender. Sky and […]
Burglars hit 4 Chatham businesses, steal empty cash drawer and cake slices from Soul Veg City: VIDEO
Burglars hit four South Side businesses, and they were caught on camera stealing an empty cash drawer and cake slices from Soul Veg City, according to the restaurant.
Political orientation and institutional trust emerge as key factors in local wind energy support
Why does the expansion of wind energy sometimes meet with local resistance, even though renewable energy generally enjoys broad support? RIFS researcher Jörg Radtke used a representative survey of 6,284 ...
Polling shows ban on trans girls in girls' sports could pass in November
Washington state voters will soon weigh in on a ballot measure to ban transgender girls from playing on girls’ school sports teams. The initiative is controversial, but national and local polling suggest it could have enough silent support to pass.
Countries race to provide oral health care for all in 100-Day Sprint across Asia
Twenty Asian countries and areas across the WHO Western Pacific and South-East Asia regions vowed to strengthen essential oral health benefits as part of a “100-Day Sprint” initiative, during the 16th Asian Chief Dental Officers Meeting held from 27 to 29 September in Kota Kinabalu, Malaysia. The meeting marked the midpoint of the 100-day sprint bolstering support for countries to develop essential oral health benefit packages that can be integrated into national universal health coverage plans. Convened by the two WHO regional offices and the Malaysian Ministry of Health as the Secretariat, the meeting brought together national oral health leaders from 20 Asian countries, staff from all levels of WHO, WHO collaborating centres and other development partners. Participating countries and areas included: Bangladesh, Bhutan, Brunei Darussalam, Cambodia, China, Hong Kong (SAR) China, India, Indonesia, Japan, Lao People’s Democratic Republic, Malaysia, Maldives, Mongolia, Nepal, the Philippines, Singapore, Sri Lanka, Thailand, Timor-Leste and Viet Nam. Participants reviewed progress and refined proposals using the WHO Service Package Delivery and Implementation (SPDI) Platform. Countries conducted bottleneck analyses across four key areas: service delivery, workforce, access to essential medicines and health products, and health financing. They identified practical actions to address implementation challenges and refined proposed revisions to their national oral health benefit packages. “There is no health without oral health. Through the 100-Day Sprint, countries are advancing the implementation of the Western Pacific regional implementation plan on oral health and strengthening progress towards universal health coverage,” noted WHO Regional Director for the Western Pacific Dr Saia Ma'u Piukala. Participants identified bottlenecks and proposed workable solutions to strengthen access to essential oral health care through primary health care, sharing experiences and discussing how best to translate policy commitments into feasible and sustainable action at the country level. Malaysian Minister of Health Datuk Seri Dr Dzulkefly Ahmad highlighted the importance of prevention and primary health-care approaches to improve oral health: “Oral diseases can have lifelong consequences, yet many are preventable. By integrating essential oral health care into primary health care and promoting prevention in schools and communities, we can improve oral health across the life course.”The WHO team led by Dr Huong Tran, Director of the Division of Health Promotion, Disease Prevention and Control of the WHO Western Pacific Region and national oral health leads from over 20 Asian countries visited the SK Pekan Putatan School, Sabah for school oral health programme including flouride mouth rinsing. © WHO / V. ChaudharyDr Huong Tran, Director of the Division of Health Promotion, Disease Prevention and Control for the WHO Western Pacific Region, emphasized key collaborative roles WHO can play. “Oral diseases are the most common noncommunicable diseases, yet many can be prevented and treated through essential oral health services delivered at the primary health-care level,” she said. “By sharing experiences and using WHO tools such as the SPDI Platform, countries are accelerating progress towards universal health coverage for oral health.” “Integrating oral health into broader health services is essential for reducing inequities, expanding access and recognizing oral health as an integral component of overall health and well-being. The 100-Day Sprint provides an important opportunity to translate this commitment into practical action and ensure that quality oral health services reach all people, especially those most in need,” said Dr Suman Rijal, Director of the WHO South-East Asia regional Department of Healthier Populations and Noncommunicable Diseases. As host of the meeting, Malaysia showcased ongoing efforts to strengthen oral health care through primary health care and prevention-focused approaches, while providing a platform for countries across the two WHO regions to exchange experiences and accelerate progress towards universal health coverage for oral health. “WHO is encouraged by Malaysia's leadership in addressing the burden of oral diseases and advancing universal health coverage for oral health through practical, country-led action,” said Dr Rabi Abeyasinghe, WHO Representative to Malaysia, Brunei Darussalam and Singapore. Countries will continue to refine and figure costs for national oral health benefits during the remaining sessions of the 100 days. These efforts support implementation of the WHO Global strategy and action plan on oral health 2023–2030, while also helping to expand access to essential oral health services through stronger and more equitable health systems across the WHO Western Pacific and South-East Asia regions.______________For more information, or to arrange media interviews, contact: WHO Regional Office for the Western Pacific: wprocom@who.int WHO Regional Office for South-East Asia: SEMediaRelations@who.int
Canonsburg reviews business growth in workshop
Canonsburg officials and business leaders met last week to review the past six years of economic growth and plan for the future. The borough has seen a marked upswing in downtown business growth in recent years thanks to targeted redevelopment efforts, local business associations and a focus on diverse local events to drive customer traffic. […]
Science Must Move Faster Than Social Media
I have bought produce, cooked it, sold it, specified it, promoted it, walked fields with growers, stood in packing houses, worked with distributors and watched chefs turn raw ingredients into something people want to eat.
Hochul, Blakeman campaign in Erie County as governor’s race enters final month
With less than a month until Election Day, the race for New York governor ran through Western New York Monday.
After FBI departure, Andrew Bailey says his focus is not on 2028
Andrew Bailey walked out of the J. Edgar Hoover Building in Washington, D.C. Friday and was back in Missouri watching his son play football Saturday, ending a roughly 13-month stint as co-deputy director of the FBI.
Hochul and Blakeman spar over Trump influence
The upcoming visit brings up a tough question for Republican candidates in New York and elsewhere.
Irene Butter: Public Health Scholar, Holocaust survivor, dies
Beginning in 1966, Butter taught at the University of Michigan, focusing on health care, midwifery, and women's health. She became Professor Emeritus of Public Health in 1996.
Hawaiʻi Island program bridges the gap between food and health
Through a partnership with the Hawaiʻi Island Community Health Center and the Food Basket, the initiative provided 25 patients with weekly food boxes that are completely locally sourced to measure how regular access to healthy, local foods would impact their overall health.
Keldon Johnson Makes Ruling on Spurs' Starting Lineup Situation
The San Antonio Spurs have more than enough options for the starting lineup, which means some players will feel snubbed. Keldon Johnson explained why he doesn't care what his teammates think.
The Harvard Crimson (@theharvardcrimson)
24 likes, 0 comments - theharvardcrimson on October 5, 2026: "Caroline B. Kennedy ’80 introduced the Institute of Politics’ 60th anniversary forum Thursday, marking her first known public appearance at the Institute since she resigned from its Senior Advisory Committee more than six years ago. Kennedy — the daughter of President John F. Kennedy ’40, to whom the IOP is dedicated – stepped down as the committee’s honorary chair in 2020 amid concerns over the IOP’s diminished independence, declining programming, and tensions with Harvard Kennedy School leadership. Full story linked in bio. 🖋: Jen L. Phan and Mirei S. Saneyoshi 📷: Grace E. Yoon".
INTERVIEW: Community Health Assessment
The Chippewa, Dunn and Eau Claire City-County Health Departments are conducting a community health assessment and are asking for your thoughts.
Knicks’ 3 Most Intriguing Regular Season Matchups
As the regular season approaches, the Knicks will officially go from the hunters to the hunted. After a wild offseason, especially in the significantly strengthened Eastern Conference, the defending champions will face much tougher challenges this season. Teams in the East like the Miami Heat, Toronto Raptors, and Philadelphia 76ers all made moves to strengthen …
Former ASU swimmer Grant House helped reshape college sports
Five years after becoming the lead plaintiff in House v. NCAA, former Arizona State swimmer Grant House reflects on the lawsuit that helped reshape college athletics, the leadership lessons he learned and his continued fight for athletes’ voices and collective bargaining with the Protect College Sports Act making its way through Congress.
Cresset Aims for $13.1B Trust Business with NAT Deal
Cresset would fold its existing $5.5 billion trust division into the $7.7 billion NAT platform while continuing to grow through clients, acquisitions.
Legends Radio spotlights JB Berkow’s lifelong art passion
JB Berkow is the founder of Benzaiten Center for Creative Arts in Lake Worth Beach. LEGENDS RADIO / COURTESY PHOTO This week's Legends Radio Local Artist Spotlight shines on accomplished artist and passionate advocate for the arts, JB Berkow. For more than five decades, JB Berkow has dedicated her life not only to creating art but also to making sure art has a place to thrive. Her work has been exhibited throughout the country in galleries, museums, and universities, and is held in permanent collections, including the Vatican’s Contemporary Art Collection in Italy, Boston University, and Palm Beach International Airport. Her passion for supporting other artists began early. At age 26, Berkow founded Touchstone Gallery in Washington, D.C., which became a highly successful cooperative gallery. She later brought that same entrepreneurial spirit to South Florida, founding Frenchman’s Art Gallery and Studios in Juno Beach in 1995. She opened Rosetta Stone Fine Art Gallery in 2003. In 2015, JB took her commitment to arts education even further by founding the nonprofit Benzaiten Center for Creative Arts. The 15,000-square-foot facility in Lake Worth Beach is home to Florida’s largest publicly accessible glassblowing hot shop and offers instruction in glassblowing, fusing, flameworking, and glass casting. The center also provides free classes to approximately 1,000 underserved children and young adults with disabilities each year. Its “Fragments Reimagined” art therapy program for veterans with PTSD recently received a $100,000 Impact 100 grant. In addition to her work as an artist and advocate, Berkow has authored four books, including Shades of Love and What They Didn’t Teach You in Art School. For JB, art has always been about more than creating something beautiful. It’s about opening doors, inspiring others, and making creativity an important part of life.That is why JB Berkow is in this week’s Legends Radio Local Artist Spotlight.
SUV crashes into Winchester business
The vehicle accidentally went through the front door of Melanie’s Premium Outlet on Bypass Road, according to a social media post by the business.
Health Influencer Brags About Drinking From a Radioactive Jug for 250 Days Straight
Radium water products were banned in the U.S. roughly a century ago for causing cancer and other harms.
Byram business owner relocates man experiencing homelessness brought into city
A Byram entrepreneur recorded himself assisting a man experiencing homelessness by offering him a ride and relocating him outside the city.
College of Ag Sciences clubs get philanthropy boost from visiting ag company
Three clubs in Penn State’s College of Agricultural Sciences got a recent boost from a new donation from Pivot Bio, a company specializing in products that optimize crop production through specific nitrogen delivery.
Pittsburgh Oktoberfest returns with food, music and Ferris wheel
Pittsburgh's annual Oktoberfest celebration has officially kicked off with German-inspired food, drinks and entertainment in the heart of downtown Pittsburgh through Oct. 11.
Pittsburgh Oktoberfest returns with food, music and Ferris wheel
Pittsburgh's annual Oktoberfest celebration has officially kicked off with German-inspired food, drinks and entertainment in the heart of downtown Pittsburgh through Oct. 11.
West Philadelphia entrepreneur brings water ice business to Disneyland
A West Philadelphia entrepreneur has brought a Philadelphia favorite to Disneyland, making history in the process.
Art, science and climate futures converge through international symposium
What: SCI_ART: After the Data/Cultural Climate Futures Symposium Who: Artists […]
The Googlebook era is here: some first impressions of the hardware and a whole new OS
Today is the day. After months of tracking code commits, dissecting leaks, and getting that unforgettable first taste at Google’s media showcase in New York City, Googlebooks are officially landing...
Patient's cancer diagnosis reinforces value of expert care and personal connection at ECU Health
A breast cancer diagnosis reinforced the value of expert care and personal connection throughout Dr. Lorrie Basnight’s treatment at ECU Health.
How Close Jeffery Simmons Thinks Titans Are to Winning Football
Despite an 0-4 start, the star defensive tackle insists Tennessee is on the brink of a breakthrough if they can finally master the art of forcing turnovers.
What hospice work taught me that politics never will
In hospice, the person comes before the politics, a lesson that could make public life more humane.
McAllen’s Soft-Landing Program Generates Business Interest in Tampico, Mexico
The City of McAllen is expanding its economic diplomacy efforts following a successful business engagement in Tampico, Tamaulipas, Mexico, where approximately 25 prospective business owners expressed interest in expanding into the United States through McAllen’s Soft-Landing Program.
What grade did CBS Sports give the Browns in Week 4?
The Browns did just enough to have a good grade according to CBS Sports.
Chip City closes all locations amid economic challenges
Chip City, a New York City-based gourmet cookie chain, has closed all 22 remaining locations nationwide due to tough consumer spending and evolving preferences.
Why I Don’t Think Ride Or Die Should Have Been Cancelled (And What Company Should Save It...)
(Welcome to my weekly streaming ratings report, the single best guide to what’s popular in streaming TV and what isn’t. I’m the Entertainment Strategy Guy, a former streaming executive who now analyzes business strategy in the entertainment industry. If you were forwarded this email, please subscribe to get these insights each week.) So…I recently came across a Reddit thread, talking about films on streaming, wondering why there are no reliable sources out there for streaming ratings data. Sigh. Honestly, as annoyed as I am that so many still don’t realize that we have streaming ratings, I somewhat get it. Until now, there was such a long delay between when a show or film came to streaming and when we got its viewership data; I understand why people were confused. (But, as you know, this just changed.) Also, even back in the day, how many people knew how well films did on television? Luckily, as a reader, you’re in the know. Okay, on to this week’s issue. I want to take a look at Prime Video cancelling Ride or Die and whether I agree with that decision. Overall, we didn’t have any breakout hits (no TV shows landed over 20 million hours according to Nielsen) but we have a lot of steady performers on the streaming charts. Plus, we’ll look at where $50 million in missing box office dollars went. (Spoiler: straight-to-streaming.) All that, plus new episodes of The Secret Lives of Mormon Wives, Supergirl heads to streaming, a new YA show does well on Netflix, the viewership for the Daily Wire’s $50 million fantasy show, what TV show hit-maker can’t make streaming hits, CD sales, all the flops, bombs and misses, and a whole lot more. Let’s dive right in! (Reminder: The streaming ratings report focuses on the U.S. market and compiles data from Nielsen’s weekly top ten viewership ranks, Luminate’s Top Ten Data, JustWatch and Reelgood interest data, Samba TV household viewership, company datecdotes, Netflix hours viewed data, Google Trends, and IMDb to determine the most popular content. While most data points are current, Nielsen’s data covers the weeks of September 7th to September 13th, 2026. You can find a link to my terminology here.) Subscribe Television - Ride or Die Is a Hit…But It Got Cancelled? What The Data “Says” I hate the phrase “here’s what the data says”, even though sometimes I find myself using it. If data just told us everything, we data folks would be out of a job! Data is often messy, complicated and nuanced. When it comes to strategy, many of the best decisions can’t actually use “data”, since it’s vastly too complicated to model. Anyways, I’ve been singing the praises of Prime Video’s Ride Or Die this summer, a show that did very well for them. And yet…it got cancelled. Now, usually when a show gets cancelled, a bunch of websites say “a hit show got cancelled”... Here’s the thing, though: in this case, they’re right! The data “says” that this show was a hit. Specifically, out of 522 first seasons to make a week on the Nielsen charts since 2020, it’s the 75th biggest. On Amazon, Ride or Die is eighth out of 41 first seasons: That’s top 15th percentile all time, almost exactly, which is my definition of a “hit”! I mean, outside of Reacher, Amazon needed a hit this summer! (Admittedly, Off Campus did well for Amazon in the spring, but Ride or Die performed even better.) So what happened? Why did Amazon cancel one of their rare 2026 bright spots? Well, Deadline reported a reason—which I’ll get to—but I’d break it down into three relevant questions: What is a given streamer’s reasoning? Is that reasoning sound? Could the stated reason not be the real reason? According to Deadline, Amazon felt the show “over-indexed” in middle-aged women. (This was based on leaks from within Amazon.) The logic is this: Amazon already reaches this demographic because of unlimited two-day shipping bundled with Prime, so they don’t really need more shows like this. Now, it’s my job to ask if that’s a good reason, and I’ll be honest, in this case, I don’t think it is. Sure, this show may “over-index” in middle-aged women—I’ll just assume that’s the case here—but I think folks often oversell how important over-indexing actually is. When a show is a “hit”, it isn’t a bit bigger than its rivals; it’s usually multiples bigger. For example, Elle only made the charts for two weeks at 8.3 million hours each. So Ride or Die was 80% bigger in its first two weeks, and likely had a much stronger hold, with its terrific 13 million hours in week three. Ride or Die was nearly three times bigger than Sterling Point through three weeks too. And that means that _Elle, Sterling Point a_nd other Amazon YA shows need to not just over-index a little with younger women (assuming that’s who Amazon prefers over middle-aged women), but massively over-index. Otherwise, more people in that demo (and a bunch more besides) likely watched Ride or Die. (I’ll try to explore this concept more in a future article.) And don’t get me started on how Ride or Die did compared to a certain (very, very popular, possibly the world’s most popular) YouTuber’s reality show…which didn’t make the charts after its first week and likely cost much, much more than Ride or Die. All to say, Amazon-MGM Studios/Prime Video can tell reporters that this show didn’t reach the right audience, but that excuse feels weak to me. So this leads to the third question: could other reasons have come into play? Yes! Renewal or cancellation decisions rarely (I’m tempted to say “never”) boil down to one variable. At its simplest, it’s two things: budget versus viewership. But often factors like critical acclaim, ownership and, yes, personal opinion come into play. In this case, Amazon has a new executive running things, and this show isn’t owned by Amazon-MGM Studios (unlike Elle). And yes, it may not have indexed with the right target viewers, too. Likely all of those factors came into play.1 My guess is ownership ended up mattering most. Amazon doesn’t own Ride or Die. It’s actually produced by another major studio. Fortunately/allegedly, this show is being shopped around. I can think of one brand new CEO who should consider it for one of his two major streamers…especially if he wants to rebuild goodwill in Hollywood. His name is on this list of exec producers of Ride or Die… If David Ellison needs some goodwill—and he does—rescue this female-led show tomorrow and grab some good headlines for a day. The data justifies it. Quick Notes on TV We’re just getting started with this issue, but the rest is for paid subscribers of the Entertainment Strategy Guy, so if you’d like to find out… How The Secret Lives of Mormon Wives latest season did on Hulu, post-controversy... Whether Supergirl soared on HBO Max... Why the box office is losing money due to the streamers... The viewership for the Daily Wire’s $50 million fantasy show... Updates on The Gentlemen, Lanterns, Outer Banks, King of the Hill and more... What former hit-maker has three streaming flops in a row... Whether The Mandalorian and Grogu popped in week two... All the flops, bombs and misses... And a whole lot more... ...please subscribe! We can only keep doing this great work with your support. If you want an idea of just how much content you’d get in a full issue, check out this older issue. Coming Soon! Oh man, we’re almost caught up! We just have two more issues, then the streaming Ratings Report will be coming out just two weeks after a TV show premieres! Next issue, I’ll be looking at the first two weeks of the NFL Thursday night games on streaming, a huge new spinoff, Reacher’s Neagly on Prime Video, and the latest edition of Monster: The Lizzie Borden Story on Netflix, the return of Slow Horses on Apple and MobLand (quietly one of their biggest shows) on Paramount+, and Dancing with the Stars on both ABC and Disney+. Plus I’ll take a look at animation for adults in 2026. The week after, a ton of movies are coming to streaming: Toy Story 5 on Disney+, Backrooms on HBO Max, Jackass: Best and Last on Paramount+ and The Breadwinner on Netflix, plus a Unabomber film on Netflix and a romcom on Prime Video. Woody Harrelson and Matthew McConaughey have a show on Apple, along with a game show inspired by Willy Wonka that everyone seems to hate. Long term, some crazy (but hopefully crazy like a fox) IP news. FX ordered a new Sons of Anarchy show from Charlie Hunnam, but it’s not about the biker gang. No, it features the show’s cast playing themselves in a new “meta-thriller”. Huh. And a lot of the cast is coming back. Next, Ryan Gosling is producing a Flintstones movie about a “grown-up Bamm-Bamm Rubble”. Also, huh. This one is in “early development” so we’ll see what happens. Both projects are based on IP, but also seem to have crazy takes on the IP, which I like.
Don’t pay full price for a winter jacket. We found the best deals on Backcountry’s sale (ending tonight!)
We sifted through hundreds of winter boots, jackets and outdoor gear to find the top 12 deals in Backcountry’s sale
SUV crashes through front door of Winchester business
Melanie's Premium Outlet in Winchester is temporarily closed. The owners of the business say an SUV crashed into its front door Monday morning.
Bladen Community College to host “So You Want to Start a Small Business” class and preview Pitch It Bladen 2027
The Small Business Center at Bladen Community College invites aspiring entrepreneurs to attend “So You Want to Start a Small Business” on Tuesday, Oct. 13, 2026, from 6:00 p.m. to 8:00 p.m. in Building 14, Room 104. This class will help participants explore what it takes to become an entrepreneur and take the first steps toward turning a business idea into reality.Participants will explore the entrepreneurial mindset and consider whether they have the interests, characteristics, motivation and willingness to take on the challenges of business ownership. The class will encourage attendees to examine their personal goals, expectations, strengths and readiness to pursue entrepreneurship.Attendees will also gain insight into the realities of starting and operating a small business, including the commitment, planning, decision-making and perseverance required to build a successful venture. Whether participants are just beginning to consider business ownership or already have an idea they want to pursue, this class will provide a foundation for determining their next steps.In addition to the class instruction, attendees will receive advance information about the upcoming Pitch It Bladen 2027 Business Competition, including the application form and details about the program. Individuals who are ready to move forward may submit their applications early and have the opportunity to receive advance acceptance into the program.Pitch It Bladen helps aspiring and emerging entrepreneurs develop their business ideas through structured instruction in business planning, financial management, cash-flow projections, marketing and operations. Participants work toward completing a business plan and preparing a business pitch, with the opportunity to compete for cash prizes.Last year's Pitch It Bladen program demonstrated the value of investing in local entrepreneurs by helping participants strengthen their business knowledge, develop their business plans and prepare to present their ideas. The competition showcased the creativity and potential of Bladen County's small-business community and provided participants with practical tools to move their business goals forward.Building on that success, Pitch It Bladen 2027 will provide another opportunity for local entrepreneurs to gain knowledge, build confidence and take meaningful steps toward launching or growing a business.“The Small Business Center wants to help individuals make informed decisions about entrepreneurship before they take the leap into business ownership,” said Theresa Dennison, Small Business Center director, in a press release. “This class gives participants an opportunity to evaluate whether entrepreneurship is right for them while also introducing them to Pitch It Bladen 2027 and the resources available to help them succeed.”Registration: Visit www.ncsbc.net and search for the class by name, or contact the Small Business Center at 910-879-5572 for additional information.
The Packers’ easy portion of the schedule is over
Moving forward, Green Bay Packers’ schedule is much tougher than the first four weeks of the 2026 season
Andoni Iraola pushed closer to finally signing Mohamed Salah's successor
Mohamed Salah exiting Liverpool was one of the biggest stories to emerge from Anfield this summer.His fallings out with Arne Slot eventually became too much and, even though he had a year left on his ...
Ohio Democrats’ path to governor’s office runs through rural areas that have turned against party
Democrats say their nominee for governor in Ohio, Dr. Amy Acton, represents the party’s best chance in years to win that office.
Iowa Legislature expands MEGA program, creating path for steel plant incentive
During a special session on Friday, the Iowa Legislature expanded the Major Economic Growth Attraction (MEGA) program, paving the way for a tax incentive for Mesabi Metallics to construct a steel plant in Lee County. Gov. Kim Reynolds signed the bill into law on Friday. The MEGA program, administered through the Iowa Economic Development Authority,…
Discover the stats from Mexico’s Clásico in Oakland
Guadalajara once again showed that El Clásico de México is a game like no other. On a night that brought thousands of Chivahermanos together in California, the Sacred Flock claimed another victory i...
Florida running back apologizes to coach after disappointing game
Florida Gators running back Jadan Baugh entered Saturday’s game against the Missouri Tigers as a legitimate Heisman Trophy contender. Unfortunately for him and the Gators, he didn’t exactly perform that way on Saturday. Now, he’s apologizing directly to his coach. Just a week after a lopsided win over Ole Miss thrust the Gators into the…
Jumbo $5.8B freight brokerage deal will ripple through Chicago
C.H. Robinson is buying RXO, the parent company of Coyote Logistics.
How a controversial camera system is monitoring mental health patients
The Lampard Inquiry started back in September 2024 and I remember going to the first hearing in Chelmsford. Subscribe The bereaved families made placards of their loved ones, they stood outside in silence and then laid flowers to mark the moment. Now, two years on, in a process meant to last another two years, there’s been a development. Last week, we were told the chair, Baroness Lampard, pictured below, could be looking at making interim recommendations. Throughout the process, she has remarked that although this inquiry is looking at almost 2,000 people who were under the care of Essex mental health services from 2000-2023 when they died, the findings could have national implications for other trusts. ‘Records 24 hours a day in patient’s bedroom’ So why has this happened? One system that the inquiry is going to take a closer look at is a controversial monitoring system called Oxevision. It monitors some vital signs of patients remotely by using a camera placed in a room. It’s used by 40% of NHS mental health trusts. But campaigners, particularly the group Stop Oxevision, have asked for this technology to be removed from mental health wards as soon as possible. I spoke to a member, Hat Porter, today and they described to me what they thought this technology did and explained their concerns: “It records 24 hours a day and it’s located in a patient’s bedroom, which is obviously somewhere you’d usually expect to be a private place. “Our concerns are that the use of the technology has been has been kind of implemented as a substitute for proper in-person support, that it’s kind of over relied on and that there’s a lot of misunderstandings and that the presence of a camera, which has often been used without people’s consent, sometimes without even their knowledge, that that has a really big impact on privacy, dignity and human rights.” ‘Not sufficient’ I put it to them that the company behind Oxevision would dispute their claims about consent and in videos I’ve seen online from NHS trusts, they make it clear that the technology is complementary to trained staff and not a replacement. [ ](https://channel4news.substack.com/p/the-nottingham-inquiry-what-lessons) [ How the Nottingham inquiry shines a spotlight on other key mental health care failings ](https://channel4news.substack.com/p/the-nottingham-inquiry-what-lessons) Victoria Macdonald · Feb 12 [ Read full story ](https://channel4news.substack.com/p/the-nottingham-inquiry-what-lessons) A team of lawyers has been working on the inquiry and with bereaved family members who have concerns about this technology. I spoke to solicitor Priya Singh, from Hodge Jones & Allen, who made the point that questions usually asked by nurses would be missing from using devices like this. “It’s not sufficient to say, oh, the patient is moving around. Somebody must go in and say, are you okay? Are you distressed? Do you want help? Is there anything I can do? Share Channel 4 News “How are you spending your time? So I think a lot of our families cannot see the function of it when ultimately the patient should only really be observed when they’ve been prescribed to be observed, they can be observed more, but that more should really be happening face to face.” The Chair will hear evidence over the next two weeks and then a decision made after that, which could have national impact if she does decide this technology should be investigated or even removed. The Department of Health and Social Care said: “The Government is committed to ensuring that lessons are learned from the Lampard Inquiry to improve patient safety. “We are confident that the Inquiry will play an important role in identifying wider learnings for the health system following the tragic events in Essex and will contribute to improvements in patient safety.” We approached LIO Health, which runs Oxevision, for comment. Subscribe Share Channel 4 News Leave a comment
Gypsy Rose Blanchard addresses 'significant tension' with Ken Urker's sister
Gypsy Rose Blanchard is responding to criticism from Ken Urker's sister following the death of Urker, the father of her daughter.
Supreme Court kicks off new term with major climate case
The Supreme Court returns for its new term on Monday, and oral arguments in a major case over the fate of a costly climate change lawsuit brought by Boulder County, Colorado, will kick off a term set to feature several blockbuster legal battles. Suncor Energy v. County Commissioners of Boulder County will decide whether a […]
State leaders detail plans to support HUSKY Health D recipients ahead of new rules
State leaders shared plans today to support people who get their health insurance through HUSKY Health before new rules start next year.
1.2K views · 22 reactions | Nobel Prize 2026 explained: the...
Nobel Prize 2026 explained: the breakthrough that lets scientists switch brain cells on and off with light. Known as optogenetics, this technology helps researchers map the brain and uncover the...
God Packs are Officially Coming to Magic: The Gathering
Magic: The Gathering booster packs have gone through a lot of changes in the last decade, some of which have been awful. But Wizards of the Coast are introducing 'God Packs' to MTG, which could feel like winning the lottery.
49ers’ Mike Evans Reveals Truth About Playing Through Rib Injury
Mike Evans was not expected to play this week. He suited up anyway. The San Francisco 49ers receiver played through a painful rib injury in a 24-14 win over the Denver Broncos. Evans Beats the Odds for the 49ers Evans hurt his ribs in Week 3 against the Arizona Cardinals. Many assumed he would miss […] The post 49ers’ Mike Evans Reveals Truth About Playing Through Rib Injury appeared first on HEAVY.
Some Democrats don’t expect to fill a Supreme Court vacancy under Trump
Democrats need a net gain of four seats to capture the Senate. If so, they’d control what happens in a vacancy, as Justice Samuel Alito admits he’s thought about retirement.
Mauricio Pochettino praises Cavan Sullivan after landmark goal against Mexico
U.S. Men's National Team boss Mauricio Pochettino has given his thoughts on Cavan Sullivan after he became the youngest goalscorer in team history against Mexico
Supreme Court rejects Michigan woman's appeal over school's ban on 'Let's Go Brandon' sweatshirts
The mother of two boys says their First Amendment rights were violated when they were told to take off the sweatshirts she bought them for Christmas in 2022.
Gen Z women want politicians who can make the ‘American dream’ feel attainable
Affordability is the top issue for Gen Z women. But few candidates are appealing to them with a message strong enough to cut through the noise.
Gen Z women want politicians who can make the 'American dream' feel attainable
Affordability is the top issue for Gen Z women. But few candidates are appealing to them with a message strong enough to cut through the noise.
After school programming, birthday parties and day camps at Brooklyn Science Spot in Carroll Gardens (sponsored) | Brooklyn Bridge Parents - News, Events and Family Services
Brooklyn families, get ready for a fall experience that goes beyond worksheets, screen time, and ordinary after-school programs and camps. At Brooklyn Science Spot, we are opening the door to a whole new way for children to learn, explore, and fall in love with science through hands-on discovery, creative thinking, and real-world STEM fun. Opening
Olivia Rodrigo’s Unraveled tour might be 2026’s best
WASHINGTON – For her third major tour, Olivia Rodrigo literally brought herself some well-deserved flowers.
Pat Bryant catches all three targets
Denver Broncos WR Pat Bryant (ankle) caught all three of his targets for 47 yards in Week 4 before exiting with an ankle injury.
Science highlights six landmark DNA and Human Genome Project breakthroughs that missed the Nobel Prize
From Avery’s genetic material discovery to the Human Genome Project’s 3 billion base pairs, major life-science advances faced Nobel limits on co-authorship and timing
NWA C-Suite: Daniel Harr
Harr joined packaging systems manufacturer Delta Systems & Automation in 2013 and advanced through leadership roles in supply chain, customer care, operations, and general management before becoming CEO in 2024....
Traders Purchase Large Volume of Call Options on Sphere Entertainment (NYSE:SPHR)
Sphere Entertainment Co. (NYSE:SPHR - Get Free Report) saw unusually large options trading activity on Monday. Traders bought 9,775 call options on the company. This represents an increase of 1,615% compared to the typical volume of 570 call options.
58,000 Hoosiers not in compliance with new HIP work rules
The Indiana Family and Social Services Administration shared internal estimates Monday showing 58,000 Hoosiers insured through the Healthy Indiana Plan are not in compliance with federal work requirements set to take effect next year.
Florida's Jadan Baugh Has Another Tough Challenge Against South Carolina
After Missouri stifled the Heisman frontrunner, the Gators must revive their ground game against a relentless Gamecocks front to avoid a devastating mid-season collapse in Columbia.
Business in brief: Oct. 5, 2026
Weekly news and notes from the Henrico business community. Better Business Bureau serving Central Virginia, headquartered in Glen Allen, has begun continuously monitoring licenses and regulatory credentials of its accredited businesses through a partnership with Branvio Inc. BBB said the system replaces repeated manual database checks and has freed more
Windows 11 26H2 brings a hidden performance boost — and may slash RAM usage
Windows 11 26H2 quietly brings several performance improvements, including a Low Latency Profile that makes common tasks feel faster. Some users are also reporting lower RAM usage after the update, although Microsoft has not confirmed that 26H2 itself is responsible.
Livelong Women’s Health Summit Builds Momentum for 2027 Expansion
The Livelong Women's Health Summit brought together consumers, clinicians, researchers, and health experts for conversations spanning menopause, strength and performance, brain health, nutrition, hormones, and the science of aging. The Health & Fitness Association (HFA) served as a sponsor for the event.
Governor Ivey Proclaims Alabama Girls in Sports Day -
MONTGOMERY – Governor Kay Ivey on Monday proclaimed Saturday, October 10, 2026, as Alabama Girls in Sports Day, recognizing the female athletes throughout the state and reaffirming Alabama’s commitment to ensuring women and girls have the right to participate, compete … Continued
The AFC road to L.A. may go through Duval
As the stadium in Jacksonville undergoes renovations, the Jaguars will play only six games there in 2026.
Top Athletes: J|medical Brings Excellence in Sports Medicine to Allianz Stadium
On 2 and 3 October, Allianz Stadium hosted the second edition of “Top Athletes: Where Excellence Meets Evidence”, the International Congress promoted by J|medical, which brought together in Turi...
Gambit's Election Guide Fall 2026
This fall’s elections are fast approaching. Early voting starts Oct. 20 and will run through Oct. 27 (excluding Sunday, Oct. 25), and Election Day is scheduled for Nov. 3.
Top Workplaces 2026: LJA Engineering takes top spot for large businesses
Empowering employee growth through a stock ownership plan, LJA Engineering is the Orlando Sentinel’s 2026 Top Workplaces in Central Florida winner in the large business category.
Spain’s New Protest Movement Is Putting Class Center Stage
The occupation of Madrid’s Puerta del Sol by housing protesters has brought back memories of the anti-austerity revolt that began in 2011. But where the Indignados used generic populist language, this...
HEALTH MINUTE: PREVENTING DANGEROUS RSV IN INFANTS
We’re officially in respiratory virus season. The U.S. Centers for Disease Control and Prevention says it typically runs October through mid-May, and the agency expects the U.S. will see a
Hellblade studio Ninja Theory has started laying off staff, following Xbox’s announcement that it faces closure
Two separate agreements with the studio “fell through”…
Community health fair provides one-stop shop for Arlington families
Arlington's third annual community health fair brought crowds to Carlin Springs Elementary School over the weekend. From flu shots and eye exams to bike giveaways and tips for healthier eating, the event hosted by the Kiwanis Club of Arlington and VHC Health offered a one-stop shop for families. "It's a lot of fun on a
NFL looking into an official cursing at Cardinals tight end Trey McBride
Line judge Jeff Seeman was caught on camera cursing at McBride, which drew the ire of union leader JC Tretter
Eyes on Growth: TD Survey Finds Small Businesses Confident About Growth Despite Economic Headwinds and Delayed Investments
TD Bank U.S. survey finds 85% of small business owners expect stronger revenue through year-end, despite economic uncertainty and preparedness gaps.
Chelsea is leading Arsenal in the race for England international
New England star Alex Scott is one of the most sought-after players in European football, and Arsenal wants to add him to its squad.The Bournemouth midfielder has established himself as an outstanding...
'Sabores of South Philly' offers personal look inside Latino-owned businesses of AEM
'Sabores of South Philly' is a marketing campaign launched this year by the Association of Mexican Business Owners, or AEM. The networking organization has over 70 members who are all entrepreneurs of Latino descent who own businesses throughout the city.
Kim Kardashian Says She Has to ‘Hold Back’ North West, but the 13-Year-Old Calls Waiting the ‘Worst’ Advice
Kim Kardashian supports North West’s entertainment ambitions while trying to control how quickly her 13-year-old daughter takes on new opportunities. In a new Sunday Times ... Read More
George L․ Kumar: Six Biology Breakthroughs Stockholm Missed
George L․ Kumar: Six Biology Breakthroughs Stockholm Missed / Ben Barres, cancer, Colin MacLeod, Ernest McCulloch, George L. Kumar, James Till, Kavli Prize,
Ohio Democrats’ path to the governor’s office runs through rural areas that had turned against them
Democrats say their nominee for governor in Ohio, Dr. Amy Acton, represents the party’s best chance in years to win that office.
Ohio Democrats’ path to the governor’s office runs through rural areas that had turned against them
Democrats say their nominee for governor in Ohio, Dr. Amy Acton, represents the party’s best chance in years to win that office.
Delta Health Center Receives Funding
Delta Health Center, Inc. has received four awards totaling $4,660,331.59 through the Mississippi Rural Health Transformation Program, a state initiative funded by the Centers for Medicare & Medicaid Services. Governor Tate Reeves announced the four RHTP awards on September 14, as part of 167 awards totaling more than $104 million statewide. The awards announced will […]
Delta Health Center Receives Funding
Delta Health Center, Inc. has received four awards totaling $4,660,331.59 through the Mississippi Rural Health Transformation Program, a state initiative funded by the Centers for Medicare & Medicaid Services. Governor Tate Reeves announced the four RHTP awards on September 14, as part of 167 awards totaling more than $104 million statewide. The awards announced will […]
Scientists reveal what seven days of fasting does to the human body
Scientists found that prolonged fasting triggers major changes throughout the body, but many of the most interesting effects only appeared after about three days without food. The results suggest fasting may influence health in ways that go beyond weight loss and could eventually inspire treatments that mimic its effects.
Business Ingenuity Gives Birth to Edgy, an AI Agent Educated in the Theory Behind Natural Synergy™ to Show Leaders Where Their Organizations Are Headed
SAN FRANCISCO, October 05, 2026--Business Ingenuity, Inc. today announced the availability of Edgy, an AI agent educated using Natural Synergy: From Natural Mystery to Mastery, co-authored by co-founder Charles Follett and Ray Scott and available on Amazon. Edgy analyzes an organization through its public footprint and its own people, then tells executives which Operating State the organization occupies, which direction it is being driven, and what adjustments would improve its performance.
Success Supper Club
Drew native Stafford Shurden is bringing entrepreneurs together to exchange ideas America was built on the backbone of entrepreneurs. Through the centuries, visionary men and women in this country saw opportunities not only to develop and grow a business, but also to forge a path to encourage and inspire others. Drew native, Stafford Shurden […]
What Holding Eye Contact While Someone Speaks Really Reveals About Your Psychology, According to Science
You are mid-conversation with a friend, nodding along, and suddenly you wonder: am I looking at them too much? Or not enough? Most of us treat eye contact like an automatic reflex – something we either do or don’t, without thinking twice. But researchers say the way you hold someone’s gaze while they speak is...
‘An anchor’: Oakshire fans celebrate, grieve as business prepares to shut down
Oakshire Public House has been a gathering space in the Whiteaker neighborhood since 2013 and holds many individual and community memories. Oakshire as a company is closing, but it plans to transition the Public House to a new company in the next two months, keeping the location open through the process.
Yale School of Medicine On the Science of Childhood Anxiety, Say, Anxiety Disorders Are the Most Common Mental Health Challenges In Youth
Credit: Matt Bradbury October 5, 2026 - By Isabella Backman - Anxiety disorders are the most common mental health challenges in youth. Left untreated, they can disrupt the lives of both children and their families. The good news is that with intervention, most children will overcome these conditions. Across Yale School of Medicine, scientists are working to understand anxiety at every level, from common anxious behaviors to molecular biomarkers in the brain. They are using their findings to develop and disseminate new evidence-based treatments for childhood anxiety. Today, the go-to treatment for childhood anxiety disorders is cognitive behavioral therapy (CBT). This is a form of psychotherapy that teaches children skills for confronting anxious thoughts and helps them practice managing situations that cause anxiety. While it is the gold-standard treatment backed by considerable scientific evidence, up to 50% of children will not see sufficient benefit from CBT alone. Wendy Silverman, PhD, Alfred A. Messer Professor in the Child Study Center, co-directs the Anxiety and Mood Disorders Program alongside Eli Lebowitz, PhD, associate professor in the Child Study Center. One of their main interests is learning how to improve outcomes beyond CBT. “We’re developing cutting-edge, research-based knowledge that can reduce the suffering that anxiety causes children and their families,” says Silverman. Changing parent behavior YSM experts are investigating how to improve CBT outcomes for children by involving the parents. Silverman’s research has uncovered two main components of parent intervention that improve childhood anxiety: not enabling children to completely avoid the things that make them anxious and taking steps to enhance their autonomy. Parents may unintentionally reinforce their child’s anxiety by allowing them to avoid what makes them anxious. They also may unintentionally limit the children’s sense of autonomy by being overly intrusive. “One of the things that we take pride in is that we’ve focused on trying to understand what parents need to do, and to test our ideas and see if changing the parents’ behaviors is enhancing the effects of CBT,” Silverman says. “Our findings thus far suggest that they do." As much as CBT can be helpful, it can also be challenging to get one’s child to do the necessary steps for CBT to work. This is one important reason why Lebowitz created a novel intervention program for parents named Supportive Parenting for Anxious Childhood Emotions (SPACE). Existing intervention programs often teach parents to act as therapists for their child, such as training them on how to practice breathing exercises. “It makes sense, but this doesn’t work very well in practice,” says Lebowitz. “And part of the reason, I think, is that it’s not easy to get your kid to do things, especially if they’re not excited about doing it.” SPACE is unique because it focuses entirely on parent involvement and changing parental behavior—children are not involved in the sessions. For example, parents learn how to use supportive messages that convey confidence that their child can tolerate and manage distress. “It might sound like a parent saying to a child, ‘I get that this is really hard for you, but I know that you can handle it,’” Lebowitz says. The program also works with parents to identify the ways in which they are accommodating anxious behaviors. “We’ll pick one thing that parents are doing that is an accommodation and help them make a detailed plan for how they’re going to change that,” Lebowitz explains. Treating Anxiety in Children and Adolescents Much of the existing research on SPACE has focused on parents of children under age 14. Ongoing studies are now exploring its use with parents of older teens. “Both anxiety and accommodation can interfere with normative developmental shifts during the teen years, including increased autonomy and individuation from parents,” says Rebecca Etkin, PhD, associate research scientist in the Child Study Center. “In this sense, SPACE may be particularly well-suited for anxious teens and their parents. We want to see whether it is effective during this distinct developmental window.” Unfortunately, many families in need of CBT face barriers, including limited availability of services and geographic constraints. One way to improve access is digital interventions. Silverman and her team are developing an evidence-based digitized intervention program for parents that they can access directly from their computer or smart phone. “The work we’re doing will be one of the very few parent interventions that is digitized and importantly tested for effectiveness,” she says. Creating interventions for anxiety-related challenges Silverman and Lebowitz recently received a generous gift to develop and test other interventions that help parents reduce other child anxiety-related behavioral and emotional difficulties, such as restrictive eating and unexplained somatic symptoms. One of these projects in particular focuses on understanding the risks of social media and its potential benefits, including offering a sense of connection. “A lot of research has focused on the idea that social media is harmful and the less of it the better,” says Lebowitz. “But we actually see is that this is not quite right—there are negatives, but there are also positives. So, we’re trying to get a little bit more nuanced of a picture.” The team is working with teens with social anxiety and their parents over an extended period to better understand their social media habits and how their anxiety levels affect engagement with different platforms. The teens will answer questions sent to an app on their phones about mood and social media usage in an effort to capture emotional responses as they unfold. “We hope to develop interventions that can help make the best of social media while protecting against the more problematic effects,” Lebowitz says. The brain’s role in anxiety Researchers are also testing therapies to address anxiety at the neurological and molecular levels. In collaboration with Dylan Gee, PhD, professor of psychology in Yale's Faculty of Arts and Sciences, and Hilary Blumberg, MD, John and Hope Furth Professor of Psychiatric Neuroscience at Yale School of Medicine, Lebowitz and Silverman are using brain imaging to identify changes in a child’s brain before and after parents enroll in SPACE. In one study, children viewed anxiety-inducing images while undergoing magnetic resonance imaging (MRI); the researchers conducted scans with and without the children’s parents nearby. Before SPACE, children’s brains were better able to activate the regulatory circuitry needed to turn off an anxious response when their parents were nearby. But after SPACE, children could activate this circuitry even without the parent around. “As parents work on gradually reducing some of their accommodations, you can see a child get better at regulating their own fear system in the brain,” Lebowitz says. “It’s remarkable.” Research into the molecular underpinnings of anxiety can also inform new childhood anxiety treatments. In a recent study, Lebowitz, Silverman, and Flora Vaccarino, MD, Harris Professor in the Child Study Center, discovered that a protein known as fibroblast growth factor 2 (FGF2) could be protective from the toxic effects of stress. FGF2 levels in children and their parents were linked to the children’s risk of developing anxiety and depression, the study showed. The findings could help explain why some children who are exposed to early life trauma such as poverty or abuse are more prone to developing mental health disorders. And FGF2 could be a target for treatment. “This is very novel because it starts to give a clue to what is the molecular chain that connects those lived experiences to the actual psychological outcomes,” Lebowitz says. New ways to study and treat childhood anxiety Michael Crowley, PhD, associate professor in the Child Study Center, collaborates with Silverman and Lebowitz to study the role that attention plays in development and maintenance of childhood anxiety. There is a large body of research that shows that anxious children, like anxious adults, are prone to focus on threatening stimuli such as angry faces compared with neutral faces. This has led to innovative interventions that involve attention retraining. The idea is that if experts train children to look away from threatening stimuli, it may reduce their anxiety—especially children with social anxiety who are most prone to attend to threats. The researchers have just completed a clinical trial for attention retraining with 10- to 14-year-olds with social anxiety disorders and are currently analyzing the findings. Besides this innovative attention retraining research, as Crowly notes, “I like to design tasks that are engaging to kids,” Crowley says. “My goal is to assess something without the kids knowing what we are assessing.” With this goal in mind, Crowley has created a virtual game, named Boom, to study threat processing in children with anxiety disorders. The game is similar to that of hot potato—the child and three digital players take turns virtually passing a ball to each other’s gloves. At some point, the ball turns into a bomb, and as the bomb lands in each player’s glove, the outline of the glove turns yellow. The goal is to avoid having the bomb go off in your glove. What isn’t obvious is that the game is designed to measure different types of threatening stimuli, both ambiguous and direct. In the game, the direct threat occurs as the bomb is traveling towards your glove. The ambiguous threat is the yellow outlined glove as it is unknown where the bomb will travel next. While children play the game, Crowley’s team measures their brain activity using electroencephalography (EEG). The researchers have discovered that in kids with anxiety, the brain reacts more strongly to ambiguous threats than it does in their peers, but less strongly to direct threats. They believe that the initial abnormally large brain response to not knowing where the bomb is going impairs the brain's ability to properly respond when the threat is actually traveling the child’s way. “The brains of children with anxiety are unable to differentiate between threats you need to do something about and those that are not your problem.” Michael Crowley, PhD, develops innovative games for studying anxiety in children and adolescents.Credit: Matt Bradbury Based on these insights, Crowley hopes to study whether interventions like attention training could restore appropriate threat processing. Crowley’s team is also working on a test called the Balloon Risk Avoidance Task, which evaluates risk-taking and avoidance behaviors. It features a digital balloon that is full of air and about to burst. Kids have six seconds to let air out of the balloon. The more air they let out, the less risk they face that the balloon will pop. But at the same time, the balloon becomes less valuable as it deflates. “The more air you keep in the balloon, the more points you get,” Crowley explains. So far, the researchers have found that when the balloons pop unexpectedly, teens with social anxiety show distinct brain responses. Studying these responses can help psychologists understand the underlying pathways driving the various manifestations of anxiety. The genetics of anxiety When Thomas Fernandez, MD, associate professor in the Child Study Center and of psychiatry, was still in training, there was a lot of excitement about understanding the genetics associated with autism spectrum disorder. Since then, scientists have identified around 250 genes associated with autism. The genetic contribution to anxiety disorders, on the other hand, has historically received less attention. Anxiety is less heritable than autism, but the genetic contribution for anxiety disorders that emerge in childhood may be higher than for anxiety disorders overall. While scientists estimate the heritability of anxiety disorders in general to be around 30% to 50%, some studies suggest higher heritability for certain childhood-onset anxiety presentations. “I saw firsthand how researchers in the field went about finding vulnerability genes for autism,” Fernandez says. “So, we’re using a very similar playbook for childhood anxiety.” “I saw firsthand how researchers in the field went about finding vulnerability genes for autism. So, we’re using a very similar playbook for childhood anxiety.” Thomas Fernandez, MD Associate Professor In the Child Study Center and in Psychiatry Now, Fernandez and Emily Olfson, MD, PhD, assistant professor in the Child Study Center, are studying children and their parents to identify genetic changes that are present in the child but not the parents, known as “de novo mutations.” “All of us have some de novo mutations—maybe about 50 to 100 sprinkled throughout the genome,” Olfson says. “But when they occur within the coding regions of genes, they can be really disruptive.” Previous research shows that people with autism have higher rates of damaging de novo mutations than the general population. In 2022, Olfson, Lebowitz, Silverman, and Fernandez published a study on 68 children and their families that found that children with anxiety had similarly high levels of these mutations. Studying de novo mutations can help point the researchers to where they should be looking for genes associated with anxiety. “The end game is using the genes to steer us toward the right part of biology that we can then target to come up with better treatments,” Fernandez says. Building on those findings, the team is now studying more families to better understand how these de novo mutations, along with other genetic and environmental factors, shape pediatric anxiety disorders. They recently received a National Institutes of Health grant to enroll 750 new families over the next five years. Olfson is the principal investigator, with co-investigators Lebowitz, Fernandez, Silverman, and Shuangge Steven Ma, PhD, department chair and professor of biostatistics at Yale School of Public Health. Neurodevelopment, Risk Genes, and Mental Health Conditions - The Olfson Lab Joel Gelernter, MD, Foundations Fund Professor of Psychiatry, is interested in how different anxiety disorders differ genomically. “We are studying social phobia, panic disorder, and generalized anxiety disorder, working to understand why people differ in their risk to these specific anxiety disorders and evaluating various risk factors,” he says. Gelernter was recently involved in one of the largest studies to date of the genomics underlying anxiety disorder. The study included around 122,000 people with anxiety disorders and around 730,000 without. It found that some genetic differences associated with anxiety were linked to signaling that helps reduce overactivity in the nervous system. Many anxiety medications available today work by targeting this process. “It’s nice when the biology that you get out of a large genome-wide study ratifies things that we already know because that can help increase confidence in further findings from the study,” Gelernter says. Uncovering the neurobiology of psychiatric disorders John Krystal, MD, Robert L. McNeil, Jr. Professor of Translational Research and chair of the Department of Psychiatry, is interested in the neurobiology of psychiatric disorders, including post-traumatic stress disorder (PTSD), of which anxiety is a major symptom. In the late 1980s, Krystal’s team discovered that the drug yohimbine activated symptoms in patients with PTSD. “This was the first time we could link a specific biological mechanism to the symptoms of PTSD,” Krystal says. At the time, he adds, this finding was highly controversial. “A lot of people felt that PTSD was a purely psychological syndrome that didn’t have an underlying biology.” Since then, Krystal has dived deep into understanding the neurobiology of PTSD to learn how to better treat it. His team is evaluating the use of ketamine and psychedelics. These would be among the first treatments to be developed specifically for PTSD. They may also be applicable for other disorders including anxiety disorders, Krystal adds. An important gap in PTSD treatment is the absence of biological tests that inform how to best help patients manage their PTSD symptoms. A doctor doesn’t diagnose cancer based on how they feel. Rather, they use tests of the biology of the cancer to determine the best course of treatment. “And we can’t do that in any psychiatric disorder other than Alzheimer’s disease,” Krystal says. “But now we are building a foundation for this approach to the treatment of anxiety disorders for the first time.” Source: Yale School of Medicine
Nintendo has renewed some classic game trademarks
Nintendo has recently refreshed some trademarks for some of its older titles as it naturally does from time to time. It doesn’t mean that new entries are currently in the works, though that would be…
Jerry Jeudy finds perspective in tough times through his daughters
Jerry Jeudy's last 15 months or so with the Browns have been tough. However, he's found happiness in getting away from football with his daughters.