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Princess Diana’s brother trashes Kristen Stewart’s ‘Spencer’ movie: ‘Terrible’
Princess Diana’s brother, Charles Spencer, trashed Kristen Stewart’s ‘Spencer’ movie as ‘terrible,’ though he praised the Oscar-nominated actress’ performance for ‘capturing Diana’ in spirit.
More older vessels on seas raise underwriting risks
Declining ship demolition rates have pushed the average age of merchant ships on their final voyages to 22 years, increasing pressure on underwriters, according to Ilias P. Tsakiris…
Attacks on Health Care in the occupied Palestinian territory (01-15 September 2026)
Situation Report in English on occupied Palestinian territory about Health, Protection and Human Rights and more; published on 8 Oct 2026 by Insecurity Insight
Sean 'Diddy' Combs prison release date pushed back by 2 months
Amid reports of Sean "Diddy" Combs' "pampered" lifestyle in prison, his release date has been pushed back.
Fucoidan research surpasses 5000 papers as Marinova targets gut health, immunity and men's urinary health
With 550+ studies published in 2025 alone, Marinova is positioning its FDA GRAS and EU Novel Foods-authorised Maritech organic fucoidan for formulators targeting the prebiotic, healthy ageing and prostate health categories
Haze not ‘a threat’ to Singapore F1 race, but entertainment could be curbed
Transboundary haze from Indonesian fires has pushed city state’s air quality to unhealthy levels, but track activity will not be affected.
Unfinished Business: Silka Carries Funky Style, Serious Grit into 2026-27 Season
CHARLESTON, S.C. -- Jacob Silka's wrestling journey at The Citadel has been anything but conventional.
Orioles’ Luis De León made a strong first impression
De León was lackluster in the minors, but finished strong in the majors
Bears-Packers Rivalry Explodes as Both Sides Trade Shots
Ben Johnson wanted to revive Bears-Packers. Mission accomplished. For years, the NFL’s oldest rivalry had been defined largely by Green […]
Xbox Seasonal Savings Sale leads massive drop of 1,600+ deals across three sales
The Microsoft Store has been refreshed with new sales, including the Xbox Seasonal Savings Sale, which discounts hundreds of games, DLC, and more.
Sporticast: Can the Premier League Thrive With Fewer Stars?
On the 593rd Sporticast episode, Lev Akabas, Justin Birnbaum and Jacob Feldman fill in for Scott and Eben to discuss a week’s worth of sports business news. Justin recently published Sportico‘s annual list of the world’s highest-paid soccer players, with Cristiano Ronaldo leading the way with roughly $300 million in earnings. Only one of the …
Sony seemingly closes the door on PlayStation VR as it sells more than 40 VR patents to Meta
Sony published two original games for the PlayStation VR 2…
Continental Roadmap on Reproductive, Maternal, Newborn, Child and Adolescent Health (2026-2030) [EN/POR]
Analysis in English on World about Health; published on 8 Oct 2026 by Africa CDC and AU
Letter: People over politics
This is regarding Mary Schamehorn’s As I See It column published in the September 29 issue of The World.
Why early-season data points to Premiership style shift
Underlying numbers from the start of the Scottish Premiership season suggest a refreshed approach could be taking hold across the league.
Editorial: Dave McCormick dreams of strengthening science, but Trump is researchers’ worst nightmare
In a recently published op-ed extolling the lifesaving virtues of federally funded research at institutions such as Children’s Hospital of Philadelphia, Sen. Dave McCormick called for doubling funding for the National Institutes of Health.
Sentencing date pushed to December for Newsom's ex-top aide facing federal charges
Dana Williamson, a former top political aide to key Democratic leaders in California, including Gov. Newsom, is still struggling with an unexpected health issue and a hearing to discuss her prison sentencing has been postponed.
Duke Disrespected as Undefeated College Football Team; Upset Predicted
Despite a dominant ground game and an unblemished record, the Blue Devils remain overlooked by critics. Now, an impending clash with Georgia Tech threatens their bid for national respect.
Patrick Mahomes’ Response Awaited After Maxx Crosby’s Eyebrow-Raising Revelation
Maxx Crosby and Patrick Mahomes faced each other once more as the Kansas City Chiefs and the Las Vegas Raiders clashed in one of the most exciting games this season. The AFC rivals were both 3-0 up and have been amazing this season, though it was the Chiefs that emerged victorious. The score itself was very […] The post Patrick Mahomes’ Response Awaited After Maxx Crosby’s Eyebrow-Raising Revelation appeared first on Gridiron Heroics.
World leader in livestock fertility research closes out 58-year career
After 58 years, Fuller Bazer, Ph.D., University Distinguished Professor, Department of Animal Science, will close out his scientific career
“Software is over”: Bold AI developer takes aim at Adobe with open source clones
Opus-built Creative Cloud alternatives are ambitious, free, and nowhere near finished.
Swarthmore bakery Pastry Pants has closed amid rising costs and waning business
Owner Robert Smythe said a constellation of factors pushed him to shut down the bakery, formerly located at 10 Park Ave. in downtown Swarthmore.
Calvert's Science Scores Climb, but Eighth Grade Won't Budge
Where Calvert County students shine, they shine. High school government students have finished first in Maryland for the fourth straight year, 30 points above the state. Where they are stuck, the school board did not hesitate to ask why. Calvert County Public Schools officials gave the Board of Education the district’s 2026 MCAP results in […]
ESPN BPI: Surging Timberwolves Projected 48 Wins, 95.5% Playoff Odds
The NBA preseason is underway, and the Minnesota Timberwolves opener showed plenty of promise. Now, ESPN’s Basketball Power Index is saying encouraging things about the team, too. The Wolves finished 49-33 last season, reached the Western Conference semifinals, and are entering 2026-27 with several roster changes. Just how high are the expectations for the Wolves? …
Some furloughed Star Wars Zero Company developers are returning to work, studio says
Bit Reactor, the Maryland based company, behind this summer’s well-received tactical combat game Star Wars Zero Company says that “more” of its team is returning to work after being furloughed ahead of the game’s release. This is the studio’s first statement on the matter since Game File’s August report that “most” of the development team had been furloughed—technically kept as employees, but without pay or benefits—a few weeks prior to launch. Some of those furloughs ended this week. “This week, we started the process of returning more of our team back to work at Bit Reactor, an important step forward in our continued support for Zero Company, “ Bit Reactor CEO Greg Foertsch said in a statement. He continued: “Having to ask team members to step away after we navigated unexpected business developments outside of our control and so close to launch was an incredibly difficult decision, but one that was necessary to help us eventually bring as many people back as possible. “This team means a tremendous amount to me, and I am incredibly proud of what we have accomplished together. Thank you to our fans for the incredible response to the game and for supporting us along this journey. We look forward to sharing more updates regarding Bit Reactor and Zero Company soon.” Game File reported in August that Bit Reactor had retained a small team to work on updates for Zero Company. One person familiar with the situation told Game File that the returns announced today bring the studio’s pay-rolled headcount to more than half of what it had been ahead of the furloughs. That means a considerable number of people have been brought back, but that a fair number also remain without pay. While companies in the U.S. are often legally required to publicly disclose how many people they’ve laid off, furloughs can often be kept private, for a time. The United States Department of Labor requires companies to publicly report mass furloughs if they meet specific criteria, including any expectation that they will last more than six months. For those game makers who remain furloughed by Bit Reactor, it’s now been about two months. For more about Bit Reactor, the furloughs, the studio’s back-story and the ongoing lawsuit that brought this to light, read my August report. [ ‘Most’ of Star Wars Zero Company studio Bit Reactor was furloughed ahead of launch ](https://www.gamefile.news/p/star-wars-zero-company-bit-reactor-furloughs-lawsuit) Stephen Totilo · Sep 1 Last week was meant to be a moment of triumph for Bit Reactor, the Maryland-based game studio founded in 2021 with ambitions to create a great new tactical combat game. [ Read full story ](https://www.gamefile.news/p/star-wars-zero-company-bit-reactor-furloughs-lawsuit)
Less Than 1% Of International Development Finance Targets Air Pollution
International development lenders committed $4.7 billion in 2024 to projects aimed explicitly at reducing air pollution, less than 1% of all international development finance, according to an annual analysis published Tuesday by the Clean Air Fund (CAF).
Corporation updates board on business park development
More than two decades after it was established, state and county officials are stepping up efforts for full development of a prominent parcel in southern Calvert County.
'Creator Rally' Aims to 'De-Risk' Politics for Influencers Ahead of Midterms
The goal of the virtual confab: to give creators, both budding and established, a framework for how to talk politics ahead of the midterms.
Montana State doctoral student receives inaugural fellowship for human health researchers
The new fellowship was established by longtime HIV/AIDS researcher Kathryn Follis Heivilin and her husband Gerard Heivilin to support emerging scholars.
Health organization in Wichita gives more than $1M for Kansas medical students
Wichita’s Riverside Health Foundation has given more than $1 million to Kansas Health Science University through an endowed scholarship fund established to benefit medical students.
Health organization in Wichita gives more than $1M to benefit Kansas medical students
Wichita’s Riverside Health Foundation has given more than $1 million to Kansas Health Science University through an endowed scholarship fund established to benefit medical students.
Health organization in Wichita gives more than $1M for Kansas medical students
Wichita’s Riverside Health Foundation has given more than $1 million to Kansas Health Science University through an endowed scholarship fund established to benefit medical students.
AI behaves more like a brain than a database – cognitive science’s role in its origin story helps explain why
This article by Michael Hout, New Mexico State University, and Arryn Robbins, University of Richmond, first appeared in The Conversation, republished with permission.
This Rice University professor has helped pick more than a dozen Nobel Prize winners
Pernilla Wittung-Stafshede spent years on the Nobel Committee for Chemistry. She left the role for a job at Rice — but still knew who this year’s winner was.
Mayo High School business teacher honored as distinguished educator by national nonprofit
The honor recognizes his six professional certifications in real-world finance topics.
Why Lennart Karl’s Bayern future could hinge on Michael Olise
At the age of 18, Lennart Karl has already established himself as a first-team player for Bayern Munich and as a Germany international.Following his breakthrough season in 2025/26, the question now is...
Chelsea backroom shake-up as transfer chief set to leave
Laurence Stewart will depart after four years with the club, with his duties already dished out
Ohio reading scores rise. Is the science of reading working?
This story was originally published by The 74. Ohio students’ reading scores rose slightly last school year, the first the science of reading was mandated, but it’s too soon to say whether the phonics-based lessons are making a difference. About 63 percent of Ohio third graders — the grade educators have long considered the most […]
Tom Cruise digs into uncharted territory in ‘Digger’
Don’t look now, but Tom Cruise’s latest movie, Alejandro G. Iñárritu’s Digger, is not your typical Tom Cruise film. The charming, boyish-looking star of Mission: Impossible fame is shedding his familiar action-superstar image. Wearing a fat suit, cowboy boots and disheveled hair, and at one point carrying a dying cat, Cruise portrays Digger Rockwell, an egocentric, fast-talking octogenarian oil billionaire whose irresponsible drilling…
Diocese introduces Mental Health Ministry, invites all to special Mass
Earlier this month Pope Leo shared his October prayer intention for mental health ministry to be established throughout the Church, helping to overcome the stigma and discrimination of people with mental illnesses. In the Columbus diocese, the Vicariate of Catholic Social Doctrine has worked since January to animate Mental Health Ministry and support families, clergy, […]
Person hospitalized after vehicle crashes into Lemoyne business: dispatch
One person was reportedly injured after a vehicle crashed into a business in Lemoyne Tuesday night, officials said.Dispatch confirmed the crash happened around
Stats and Observations From Phoenix Suns' Preseason Opening Loss
Jordan Ott’s high-volume offensive system flashed potential through aggressive rim pressure and hustle, but sloppy ball security and mounting fouls ultimately derailed the Suns' preseason opener.
Woman hospitalized after truck crashes into northwest Miami-Dade business
A vehicle crashed into a business in northwest Miami-Dade County on Tuesday afternoon.
U. Business School researchers find that girl dads are more attentive to their partners
Two Rutgers University researchers recently published a study that found having a daughter was associated with changes in fathers' psychology, including greater investment in the relationship he has with the child's mother.
Measuring Stick for the Washington Run Defense Against Iowa
Two years ago, Iowa rushed for 220 yards on the Washington run defense, averaging nearly six yards per carry inside Kinnick Stadium. The Huskies lost 40-16 in what was just the fourth Big Ten game of Jedd Fisch’s tenure in Seattle. The loss demonstrated the physicality and stylistic gap that Washington aimed to close as …
Susan Collins and Troy Jackson clash over Trump and seniority in Maine’s first Senate debate
The two candidates clashed repeatedly on their records and about national politics in the first of four debates in the key battleground race.
Bengoa: Ten years on how much further forward is Northern Ireland's health care system?
Hospital waiting lists, access to GPs and the state of social care suggest the job is far from finished.
Dallas Cowboys' Week 5 Injury Report Sheds Light On Team Health In Short Week
The Dallas Cowboys still have multiple names listed on the injury report before Thursday night's matchup with the Tampa Bay Buccaneers.
Pregnancy complications linked to higher risk of cardiac and renal health conditions
Women with a complication in their latest pregnancy or a previous pregnancy face an elevated risk of developing cardiometabolic-renal conditions in subsequent years, suggests a U.K. study published online ...
iFixit tears down Apple Watch Series 12 and Ultra 4, finds mixed repairability results
Concluding iFixit’s teardown sequence for Apple’s September launches, iFixit today published the teardown of the new Apple Watch Series 12 and Ultra 4.
After heading home to Missouri, Andrew Bailey isn’t ruling out another run for office
The former Missouri attorney general finished a roughly yearlong stint as co-deputy director of the FBI.
Purdue Polytechnic assistant dean publishes book on creative teamwork in themed entertainment
A new book coauthored by Chris Rogers, assistant dean of Purdue Polytechnic in Indianapolis, has just been published. The new title explores how cross-disciplinary teams build world-class themed entertainment experiences.
ASU national security expert explains missteps since 9/11 attacks
The war against terror immediately after the 9/11 attacks had clear goals that were quickly accomplished, but has been followed by many missteps in the 25 years since, according to an Arizona State University national security expert.Peter Bergen, a professor of practice at ASU, recently released the book, “All the President’s Wars: Twenty-Five Years of America's War on Terror.”
Yankees Bashed Just Right by New York Post Back Page
The New York Post is famous for its back page headlines. During both good times and bad times in sports in the Big Apple, the Post captures the mood with some loud, pun-heavy headlines. Monday night was a bad night in New York City sports. The Yankees went down 0-2 in the ALDS to the […] The post Yankees Bashed Just Right by New York Post Back Page appeared first on HEAVY.
Zambia to sign revised U.S. health deal without patient data and specimen-sharing clauses
The U.S. has signed new bilateral health agreements with around two dozen African nations since last year, but some have pushed back on requirements to provide patient data.
Old Dominion University Researchers Explore Connection Between Sinus Health and Voice Problems
A stuffy nose, facial pressure and a diminished sense of smell are familiar symptoms for people with chronic sinus problems. Changes to the voice may be less obvious. Researchers in Macon & Joan Brock Virginia Health Sciences at Old Dominion University are exploring a connection patients may not always recognize: the relationship between sinus conditions and voice problems.
Scientists discover 57 new marine species lurking in the depths of the South Atlantic
A group of scientists in Argentina discovered dozens of new species in the South Atlantic Ocean, shedding new light on one of the world’s most biologically dynamic regions.
Scientists discover 57 new marine species lurking in the depths of the South Atlantic
A group of scientists in Argentina discovered dozens of new species in the South Atlantic Ocean, shedding new light on one of the world’s most biologically dynamic regions.
Scientists discover 57 new marine species lurking in the depths of the South Atlantic
A group of scientists in Argentina discovered dozens of new species in the South Atlantic Ocean, shedding new light on one of the world’s most biologically dynamic regions.
Scientists discover 57 new marine species lurking in the depths of the South Atlantic
A group of scientists in Argentina discovered dozens of new species in the South Atlantic Ocean, shedding new light on one of the world’s most biologically dynamic regions.
Scientists discover 57 new marine species lurking in the depths of the South Atlantic
A group of scientists in Argentina discovered dozens of new species in the South Atlantic Ocean, shedding new light on one of the world’s most biologically dynamic regions.
Scientists discover 57 new marine species lurking in the depths of the South Atlantic
A group of scientists in Argentina discovered dozens of new species in the South Atlantic Ocean, shedding new light on one of the world’s most biologically dynamic regions.
Brazil: Lessons from a Disaster
By Antonio Martins (Outras Palavras) Defeats become deeper and more prolonged when we misunderstand what caused them, avoid correcting course, and embrace “solutions” that only compound our mistakes. Lula’s government and the Brazilian left suffered a disaster in Sunday’s election. Contrary to every poll, the president finished the first round 2.2 million votes behind Flávio Bolsonaro—and, more significantly, 3.4 million votes below his total four years ago, when the machinery of the state was working against him and in favor of his opponent. His vote share declined in 98 percent of Brazil’s municipalities. The PL, the main party of the far right, elected 121 deputies and 28 senators, becoming the largest caucus in both houses of Congress. The parties aligned with the Centrão—Brazil’s bloc of transactional center-right parties—were somewhat diminished, but will still hold roughly 250 seats in the Chamber of Deputies and 35 in the Senate. That will make it easier to assemble the majorities needed to amend the Constitution or impeach Supreme Federal Court justices. If elected, Flávio Bolsonaro could appoint four members of the Court, substantially altering its internal balance of power. What produced these results? How can the far right be prevented from consolidating them into a prolonged political hegemony? And what is the essential change of direction the left now needs? Explaining the Disaster Across the commercial media and the exuberant chaos of digital platforms, interpretations are multiplying. Some focus on specific episodes: Lula’s absence from the Globo debate, his very close relationship with Alexandre de Moraes, or his emphasis on issues supposedly remote from most people’s everyday concerns, such as rare earth minerals. Among the more systemic interpretations, three seem especially questionable. One argues that the principal defeat was not the left’s, since its congressional representation declined only slightly. The decisive movement captured at the ballot box, according to this view, was a shift within the right itself—from the more moderate and transactional forces of the Centrão toward the more ideological and radicalized forces of the PL and Novo. A second interpretation holds that the nature of electoral and political processes has changed. The material interests and aspirations of society, it argues, no longer play the central role they once did; they have given way to forms of subjective self-identification that the left has yet to understand. And a third concludes that, because of these two developments, we should expect a political winter: a prolonged period in which the far right and the broader right dominate Brazilian political life. There are important elements in all three interpretations. The problem lies in what they deny or leave out: Lula’s third government was a small-bore government. It offered the majorities that elected it neither a clearly better life nor reasons to believe again in politics and its power to transform society. These failures flowed from two fatal accommodations, which I will examine below. As a result, the government suffered a slow but steady erosion of support. And, as has happened in so many Western countries, it gave the far right the opportunity to present itself as anti-system and to benefit from popular frustration and distress. The interpretation that emphasizes the migration of votes from the center-right and traditional right toward the far right has been advanced, among others, by the courageous journalist Leonardo Sakamoto. In his UOL column on Monday, October 5, he highlights the miserable behavior of the traditional conservative parties. Over the past four years, they repeatedly joined forces with the “neo”-fascists, helping to “normalize” them—a criticism that could equally be directed at almost the entire corporate media. Believing they could use the far right as a stepping stone, they instead ended up partly devoured by it. This was especially true in the Senate, where the PL’s gain of 13 senators and Novo’s gain of two came at the expense of the PSD, which lost nine; the MDB, which lost two; the PSDB, which lost two; and the PP, which lost one. Sakamoto’s observation is accurate and necessary, but it leaves uncomfortable questions unanswered. Why did the erosion of the Centrão benefit the far right rather than, for example, producing growth for the left—as has happened so many times before, both in Brazil and elsewhere? The answer is not difficult. Throughout its four years in office, Lula’s third government was almost invariably associated with the Centrão. Here lies its first accommodation: accepting the limits imposed by conservative institutions; avoiding, as much as possible, any attempt to strain those limits through popular pressure; and believing only in the modest changes that could be squeezed through openings in Congress. The failure of the campaign to end the six-day workweek is emblematic. Lula could have electrified the presidential race by pairing it with a popular campaign for passage of the measure. Instead, he chose to place his hopes in the hands of Senate president Rodrigo Alcolumbre. He generated no mass mobilization, did not force his opponents onto an uncomfortable defensive, and won no victory. In September 2025, the government squandered the greatest of its many opportunities to shake up conservative power in Congress. Popular opposition to the so-called Shielding Amendment—which, if approved, would have restricted criminal proceedings against members of Congress—brought crowds into the streets, mobilized primarily by artists and social movements. This opened the possibility for a broader political education: a campaign that could begin exposing the limits and dysfunctions of Brazil’s political system while putting Bolsonaro’s movement on the defensive for its predictable support of political privilege. The amendment was defeated. But the executive branch then backed away from the fight. It remained associated with an institutional world widely seen as corrupt, elitist, and indifferent to ordinary people’s struggles. In doing so, it forfeited its credibility as a vehicle for the protest vote. On Sunday, it reaped the bitter fruits. Are We Doomed? Taking a different approach from Sakamoto, the philosopher Moysés Pinto Neto and other writers have drawn attention, in their first analyses of October 4, to the fragmentation of the public sphere produced by Big Tech platforms. Through their algorithms, these platforms present each person with a different view of social reality. As a consequence, it becomes much harder to identify common material problems and demands—for example, the fight for labor rights or for a properly funded public health system. Voters no longer embrace such demands, these authors argue, because they no longer see themselves as part of a collective. Instead, they tend to value the identities assigned to them by neoliberal subjectivity—the role of the entrepreneur, for example. On this interpretation, the left’s possible error lies in clinging to outdated illusions. Moysés’s warning is highly relevant and resonates with arguments such as Naomi Klein and Astra Taylor’s “Apocalyptic Fascism and the Billionaires’ Bet.” Unlike a century ago, the far right no longer promises a radiant future. It concentrates instead on resentment—especially that of young men. “They belong to a generation that fears it may never own a home, but compensates with the pleasure it gets from constantly provoking progressives online. Convinced their future has been stolen, they share memes romanticizing historical authoritarian regimes,” the authors write. But Moysés seems to confuse this danger with inevitability. He fails to see that the left’s answer cannot be adaptation. On the contrary, it must strengthen the possibility of politics as collective action. Nor does he recognize that precisely such a reversal is already becoming possible in some of the most promising mobilizations of the twenty-first century: the election, at the end of 2025, of the young Muslim Zohran Mamdani as mayor of New York, on a platform centered on the intensely material fight for an affordable city; the Left Party’s victory in Berlin two weeks ago, built around the demand to expropriate private real-estate corporations; and the very recent wave of demonstrations in Spain—including an occupation of Madrid’s Puerta del Sol—in which tens of thousands of young people mobilized by the Tenants’ Union have demanded limits on rents. By putting itself in the straitjacket of the “fiscal framework” in the first months of 2022, Lula’s third government adopted the second fatal accommodation of its term. Faced with conservative institutions and a country devastated by four years of Bolsonaro, increased public investment was the government’s remaining weapon for offering a more dignified life to the majority and forging an anti-conservative pact with them. The same state that disburses 1 trillion reais a year to enrich a small class of rentiers could instead spend money to extend the Family Health Strategy to every Brazilian, at a cost of 30 billion reais; provide full-day public schooling and childcare to all adolescents and children—and, especially, relief to their mothers; achieve universal sanitation while cleaning up polluted urban rivers; multiply metro systems; begin transforming the urban peripheries; and undertake many other urgently needed projects. In April 2023, an article in Outras Palavras warned that the fiscal framework could “shrink the Lula government and preserve the forces that condemn the country to inequality and regression.” A year later, another article showed that restraints on public spending were strangling policies vital to ordinary people and undermining the president’s popularity. In November 2024 came a reality check, in the form of the government’s humiliating defeat in the municipal elections. Even then, the fiscal lock was neither removed nor loosened. On the contrary: throughout the government’s four years, fiscal restraint remained central to its political narrative. The administration proudly proclaimed that it had “put the state’s accounts in order,” without grasping either how misleading that phrase was—given the payment of 1 trillion reais in interest—or how badly the message was hurting it politically. Lula finally woke up in September 2026. The increase in Bolsa Família benefits, after four years of being frozen; the announcement that anti-obesity drugs would be offered through Brazil’s public health system; and the ban on online betting showed that the state has the power to act decisively on behalf of the majority when those in government are willing to confront obstacles. The huge marches that closed the campaign in Fortaleza, Salvador, Rio de Janeiro, and São Paulo on the eve of October 4 showed how such initiatives can mobilize activists and the broader public. But it was too late—and too little to change the outcome of the first round. History has not ended The possibility of a turnaround in the three weeks leading up to November 25 cannot be ruled out. It will not be simple or easy. Lula must not only make up a deficit of 2.2 million votes; he must also offset the movement of voters who backed other right-wing candidates in the first round, most of whom are likely to move toward Flávio Bolsonaro. Pulling that off will require a broad, grassroots effort to win over voters, potentially reinforced by new initiatives from Lula. The coming hours and days will be decisive. If Bolsonaro’s movement also wins the presidency, the result will create a high-risk situation for Brazilian sovereignty and democracy. The enormous challenges posed by such an outcome would require the left to reexamine, in depth and with a genuine willingness to engage in self-criticism, its political projects—or its lack of them—and its practices. But would that mean we are condemned to the long winter of far-right hegemony that some analyses are beginning to forecast? It is far too early to say, suggests a recent text by Álvaro García Linera, the thinker who served as vice president of Bolivia under Evo Morales. His central hypothesis is that this political current will prove short-lived. At a moment when the entire world is once again talking about sovereignty and protecting national economies, the far right offers a stale, recolonizing neoliberalism. Its submission to the United States is as blatant and pathetic as Flávio and Eduardo Bolsonaro’s overtures to Donald Trump. Its project amounts to something like every man for himself: greater inequality, capitalism without limits, devastation, and supremacism. Will it work? In the United States, just two years into his second term, Trump himself is reaching record levels of unpopularity and may be on the verge of losing Republican control of both the House and Senate in November. Every new beginning is difficult. Whatever the outcome of the second round, the defeats of October 4 show how profoundly the Brazilian left will have to rethink and rebuild. But just as it would be foolish to underestimate the seriousness of its mistakes, it would be equally foolish to conclude that rebuilding a political project is no longer possible. History has not ended. The times are moving faster than ever. Originally published in Portuguese by Outras Palavras. English translation by Eric Blanc; I’ve added the subtitles. More We can’t stop the far right at home or abroad without a revitalized labor movement, which is yet another reason why you should become a sustaining supporter of the Emergency Workplace Organizing Committee (EWOC) — one of US labor’s pivotal bright spots. Relatedly, Jacobin published a short piece of mine reflecting on a decade of Bernie Sanders inspiring a whole new generation of young worker organizers.
How West Michigan’s power players earned their first paychecks
Before they led companies and institutions, the Who's Who washed dishes, delivered newspapers, picked blueberries and flipped burgers.
Chris Olave Injury Update: Saints WR’s Status Revealed
Chris Olave left the Saints Week 4 loss late after taking a shot to the knees, but it appears as though the wide receiver will be ok and dodged a long-term injury. Originally selected in the first round of the 2022 NFL Draft, the Ohio State product quickly established himself as the team's go-to option …
8 Players Withdraw from ATP Shanghai
Shanghai, the penultimate Masters 1000 of the year has, in recent years, been one of the most unpredictable. Several withdrawals are already contributing to the narrative of the tournament as it’s set to get underway soon. Which Players Have Withdrawn from Shanghai? Jannik Sinner has once again pushed back his return to the court, withdrawing …
Thunder’s Reported Preseason Gamble Is Exactly Right
Prioritizing health and development, Mark Daigneault’s decision to bench established stars for hungry prospects offers a crucial evaluation of the roster’s next generation of potential contributors.
Banijay Entertainment Introduces New US Gameshow Scrambled Up to Market
Media and entertainment powerhouse, Banijay Entertainment, today announces it has acquired the global format rights and finished tape rights to Scrambled Up, an all-new studio-based word game from Michael Eisner’s The Tornante Company; Keller/Noll, the prolific US format creators Cleve Keller and Dave Noll (Chopped, America Says, Flip Side); Crazy Legs Productions; and Playing Field […]
California governor condemns Trump's 'let 'em take Los Angeles' comments
By Steve Gorman LOS ANGELES, Oct 5 (Reuters) - California Governor Gavin Newsom has lashed out at President Donald Trump for remarks to a crowd of his supporters in Nebraska's farm belt suggesting
In Business: Bemidji Woolen Mills Keeping Local Production Alive
https://youtu.be/dwmn4Xteru4 As more clothing production moves overseas, one Bemidji manufacturer is still keeping much of its work local. Behind the racks and finished products at the Bemidji Woolen Mills, much of the work here still comes down to people cutting, stitching, and sewing. In an industry where production has often…
Global experts call for coordinated action on digital health risks
The way digital technologies are currently built and governed creates real risks to health worldwide, alongside genuine benefits, according to a new three paper Series authored by 13 global experts, published in The Lancet.
Car crashes into San Luis Obispo business
A car crashed into a business on the 700 block of Footbill Boulevard in San Luis Obispo on Monday morning.
1 killed, 2 injured when car crashes into Santa Fe Springs business
One person died and two people were injured when a car crashed into a business Monday afternoon in Santa Fe Springs. The crash was reported at about 2:30 p.m. near Telegraph Road and Slauson Avenue in the community about 15 miles southeast of downtown Los Angeles. Details about what led to the crash into the front of the building, possible…
The Harvard Crimson (@theharvardcrimson)
24 likes, 0 comments - theharvardcrimson on October 5, 2026: "Caroline B. Kennedy ’80 introduced the Institute of Politics’ 60th anniversary forum Thursday, marking her first known public appearance at the Institute since she resigned from its Senior Advisory Committee more than six years ago. Kennedy — the daughter of President John F. Kennedy ’40, to whom the IOP is dedicated – stepped down as the committee’s honorary chair in 2020 amid concerns over the IOP’s diminished independence, declining programming, and tensions with Harvard Kennedy School leadership. Full story linked in bio. 🖋: Jen L. Phan and Mirei S. Saneyoshi 📷: Grace E. Yoon".
Legends Radio spotlights JB Berkow’s lifelong art passion
JB Berkow is the founder of Benzaiten Center for Creative Arts in Lake Worth Beach. LEGENDS RADIO / COURTESY PHOTO This week's Legends Radio Local Artist Spotlight shines on accomplished artist and passionate advocate for the arts, JB Berkow. For more than five decades, JB Berkow has dedicated her life not only to creating art but also to making sure art has a place to thrive. Her work has been exhibited throughout the country in galleries, museums, and universities, and is held in permanent collections, including the Vatican’s Contemporary Art Collection in Italy, Boston University, and Palm Beach International Airport. Her passion for supporting other artists began early. At age 26, Berkow founded Touchstone Gallery in Washington, D.C., which became a highly successful cooperative gallery. She later brought that same entrepreneurial spirit to South Florida, founding Frenchman’s Art Gallery and Studios in Juno Beach in 1995. She opened Rosetta Stone Fine Art Gallery in 2003. In 2015, JB took her commitment to arts education even further by founding the nonprofit Benzaiten Center for Creative Arts. The 15,000-square-foot facility in Lake Worth Beach is home to Florida’s largest publicly accessible glassblowing hot shop and offers instruction in glassblowing, fusing, flameworking, and glass casting. The center also provides free classes to approximately 1,000 underserved children and young adults with disabilities each year. Its “Fragments Reimagined” art therapy program for veterans with PTSD recently received a $100,000 Impact 100 grant. In addition to her work as an artist and advocate, Berkow has authored four books, including Shades of Love and What They Didn’t Teach You in Art School. For JB, art has always been about more than creating something beautiful. It’s about opening doors, inspiring others, and making creativity an important part of life.That is why JB Berkow is in this week’s Legends Radio Local Artist Spotlight.
Physicians Committee Applauds New Guidance on Animal Use From the National Cancer Institute
In August, the National Cancer Institute (NCI) at the National Institutes of Health (NIH) published new guidance on grant applications for studies involving animal experiments. This guidance requires researchers to justify their use of animals in the publicly available abstract section of applications and encourages them to use human-based methods.
SUV crashes through front door of Winchester business
Melanie's Premium Outlet in Winchester is temporarily closed. The owners of the business say an SUV crashed into its front door Monday morning.
Andoni Iraola pushed closer to finally signing Mohamed Salah's successor
Mohamed Salah exiting Liverpool was one of the biggest stories to emerge from Anfield this summer.His fallings out with Arne Slot eventually became too much and, even though he had a year left on his ...
Congress may be in recess, but the unfinished business is piling up
“We’ll have to see how the court sort out all the battles that are ongoing right now,” said Mitchell Miller.
CAS inducts seven into Hall of Fame
The College of Arts and Sciences (CAS) inducted seven distinguished members of the CAS community into its Hall of Fame on Friday, September 18.
Dave Portnoy on Fox ‘Big Noon’ Exit: Ryan Day Thinks I ‘Doxxed’ Him
Portnoy tells FOS that Ohio State pushed for his removal.
Unfinished Business: Dean Rajan Appointed to Historic Third Term
Madhav Rajan reflects on nine years of leading Chicago Booth and what he wants to accomplish in the years ahead.
Philanthropy: Q+A with William Ahmanson
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Stephen King and Peter Straub’s Other Worlds Than These Will Break Your Heart
‘The Talisman’ finale is an emotional adventure story, resurrecting old friends, forgotten memories, and vanished worlds.
2026 Outstanding Women in Business
The 18th annual Outstanding Women in Business awards recognize a dozen well-accomplished professionals from across the region and in many industries who go above and beyond. The committee selected the winners from more than 80 nominations, all of whom were worthy. The criteria evaluated each nominee’s professional achievements, community impact, ability to break the glass ceiling and mentorship of other professionals, particularly women. In addition to profiling these women in the following pages, the Worcester Business Journal will celebrate this year’s Outstanding Women in Business at a special luncheon on Oct. 28 at the College of the Holy Cross. To join the celebration of these exceptional women, visit WBJournal.com and register. – Mark Conti, editor This Year’s Judges Worcester Business Journal considered 54 Central Massachusetts professionals for the 2026 Outstanding Women in Business awards, based on 83 nominations. These nominees were independently evaluated by two volunteer judges, who scored each on their professional achievements, community contribution and mentorship of young professionals. Samantha P. McDonald is a partner at Bowditch. She is an experienced, client-focused real estate lawyer, concentrating on business and real estate property law. She has been recognized as a WBJ Power 100 in the Class of 2026 and a “Top Women of Law” in Massachusetts Lawyers Weekly. Dr. Kavita Babu is chief medical officer and vice president of medical affairs at Heywood Healthcare, where she provides strategic and clinical leadership to advance high-quality, patient-centered care across the organization. She is also a member of the WBJ Outstanding Women in Business Class of 2025.
DeSean Bishop Is the X-Factor Arkansas Must Contain
Arkansas knows exactly where Tennessee’s offensive plan begins. It begins with DeSean Bishop. The Volunteers running back enters Fayetteville after one of the best performances in the country this season. Bishop rushed 34 times for 220 yards and three touchdowns in Tennessee’s 24-14 win over Auburn, turning a game with quarterback uncertainty into a statement …
Chimpanzees steal less pineapple from their friends
The new research sheds more light on the evolutionary origins of friendship.
Chelsea is leading Arsenal in the race for England international
New England star Alex Scott is one of the most sought-after players in European football, and Arsenal wants to add him to its squad.The Bournemouth midfielder has established himself as an outstanding...
Pope Francis' diaries to be published next month, revealing reflections on Vatican years
Pope Francis' journal entries from his time in the Vatican and years before will be published this fall | WBBM Newsradio 780 AM & 105.9 FM
Pope Francis' diaries to be published next month, revealing reflections on Vatican years
Pope Francis' journal entries from his time in the Vatican and years before will be published this fall | Talk 1370
Pope Francis' diaries to be published next month, revealing reflections on Vatican years
Pope Francis' journal entries from his time in the Vatican and years before will be published this fall.
Heartland Catfish Unveils New Website
Heartland Catfish Company recently launched a new website in celebration of its 30th anniversary. The site has been refreshed to focus on retail and food service partnerships, give a detailed look at the company’s products and processes and emphasize consumer education about the benefits of U.S. Farm-Raised Catfish as a versatile and healthy protein source. […]
Fiserv Small Business Index Shows Small Business Sales Rise in September as Back-to-School Lifts Retail
Index rises to 146 as sales increase +2.2% year over year and +0.7% month over month MILWAUKEE, Oct. 05, 2026 (GLOBE NEWSWIRE) -- Fiserv, Inc. (NASDAQ: FISV), a leading global provider of payments and financial services technology, today published the Fiserv Small Business Index for September 2026,
Jobs in health care. Jobs for women. The US labour market is segmenting. Chernobyl’s radiation and Lenin’s love of literature.
Thank you for opening your Chartbook email. Elmer Bischoff, Two Figures at the Seashore, 1957 The only really dynamic job-creator in the US economy is health care: The largest crunch has come in Federal government, which has shed 2.7 m jobs. Source: tchouvkov on Twitter Tech is struggling. [ Joey Politano 🏳️🌈@JosephPolitano The US tech sector continues bleeding jobs in official data released today—overall, employment decreased by 17k last month and is down 69k over the last year That's nearly as bad as the worst of the 2024 tech-cession, and much worse than the 2022 boom or even pre-2020 norms 12:42 PM · Oct 2, 2026 · 15.2K Views 15 Replies · 47 Reposts · 390 Likes ](https://x.com/JosephPolitano/status/2106001807847940232?s=20) The new jobs are all for women. [ Justin Wolfers@JustinWolfers I'm not sure who saw this coming, but so far nearly all the jobs created during the second Trump administration have gone to women. 1:09 PM · Oct 2, 2026 · 33K Views 70 Replies · 146 Reposts · 644 Likes ](https://x.com/JustinWolfers/status/2106008723533533601?s=20) Meanwhile, real wages are being eaten up by modest over-target inflation. [ Heather Long@byHeatherLong The financial pain is real: Wage growth fell to 3% (y/y) in September. That's the lowest in 5 years. Wage growth: 3% Inflation: ~3.4% Inflation has eaten up all wage gains for the average worker since April. Many people are having to make hard choices about what to buy and what … 1:24 PM · Oct 2, 2026 · 37K Views 24 Replies · 275 Reposts · 533 Likes ](https://x.com/byHeatherLong/status/2106012367712620728?s=20) HEY READERS, THANK YOU for opening the Chartbook email. I hope it brightens your day. I enjoy putting out the newsletter, but tbh, what keeps this flow going is the generosity of those readers who clicked the subscription button. If you are persuaded to click, please consider the annual subscription of $60. It is both better value for you and a much better deal for me, as it involves only one credit card charge. Why feed the payments companies if we don’t have to. Subscribe Elmer Bischoff, Bathers, 1960 Americans are disillusioned with higher ed. For contributing subscribers only. Subscribe Where the Chernobyl radiation went. h/t Simon Kuestenmacher aka simongerman600 How Lenin’s love of literature shaped the Russian Revolution - Tariq Ali This, then, was the intellectual atmosphere in which Lenin came of age. His father, a highly cultured conservative, was the chief inspector of schools in his region and much respected as an educationalist. At home, Shakespeare, Goethe and Pushkin, among others, were read aloud on Sunday afternoons. It was impossible for the Ulyanov family – “Lenin” was a pseudonym adopted to outwit the tsarist secret police – to escape high culture. At high school, Lenin fell in love with Latin. His headteacher had high hopes that he might become a philologist and Latin scholar. History willed otherwise, but Lenin’s passion for Latin, and taste for the classics, never left him. He read Virgil, Ovid, Horace and Juvenal in the original, as well as Roman senatorial orations. He devoured Goethe during his two decades in exile, reading and rereading Faust many times. Lenin put his knowledge of the classics to good use in the time leading up to the October revolution of 1917. In April of that year, he broke with Russian social-democratic orthodoxy and, in a set of radical theses, called for a socialist revolution in Russia. A number of his own close comrades denounced him. In a sharp riposte, Lenin quoted Mephistopheles from Goethe’s masterwork: “Theory, my friend, is grey, but green is the eternal tree of life.” Source: The Guardian Elmer Bischoff, The River, 1953 If you’ve scrolled this far, you know you want to click: Subscribe
Yale School of Medicine On the Science of Childhood Anxiety, Say, Anxiety Disorders Are the Most Common Mental Health Challenges In Youth
Credit: Matt Bradbury October 5, 2026 - By Isabella Backman - Anxiety disorders are the most common mental health challenges in youth. Left untreated, they can disrupt the lives of both children and their families. The good news is that with intervention, most children will overcome these conditions. Across Yale School of Medicine, scientists are working to understand anxiety at every level, from common anxious behaviors to molecular biomarkers in the brain. They are using their findings to develop and disseminate new evidence-based treatments for childhood anxiety. Today, the go-to treatment for childhood anxiety disorders is cognitive behavioral therapy (CBT). This is a form of psychotherapy that teaches children skills for confronting anxious thoughts and helps them practice managing situations that cause anxiety. While it is the gold-standard treatment backed by considerable scientific evidence, up to 50% of children will not see sufficient benefit from CBT alone. Wendy Silverman, PhD, Alfred A. Messer Professor in the Child Study Center, co-directs the Anxiety and Mood Disorders Program alongside Eli Lebowitz, PhD, associate professor in the Child Study Center. One of their main interests is learning how to improve outcomes beyond CBT. “We’re developing cutting-edge, research-based knowledge that can reduce the suffering that anxiety causes children and their families,” says Silverman. Changing parent behavior YSM experts are investigating how to improve CBT outcomes for children by involving the parents. Silverman’s research has uncovered two main components of parent intervention that improve childhood anxiety: not enabling children to completely avoid the things that make them anxious and taking steps to enhance their autonomy. Parents may unintentionally reinforce their child’s anxiety by allowing them to avoid what makes them anxious. They also may unintentionally limit the children’s sense of autonomy by being overly intrusive. “One of the things that we take pride in is that we’ve focused on trying to understand what parents need to do, and to test our ideas and see if changing the parents’ behaviors is enhancing the effects of CBT,” Silverman says. “Our findings thus far suggest that they do." As much as CBT can be helpful, it can also be challenging to get one’s child to do the necessary steps for CBT to work. This is one important reason why Lebowitz created a novel intervention program for parents named Supportive Parenting for Anxious Childhood Emotions (SPACE). Existing intervention programs often teach parents to act as therapists for their child, such as training them on how to practice breathing exercises. “It makes sense, but this doesn’t work very well in practice,” says Lebowitz. “And part of the reason, I think, is that it’s not easy to get your kid to do things, especially if they’re not excited about doing it.” SPACE is unique because it focuses entirely on parent involvement and changing parental behavior—children are not involved in the sessions. For example, parents learn how to use supportive messages that convey confidence that their child can tolerate and manage distress. “It might sound like a parent saying to a child, ‘I get that this is really hard for you, but I know that you can handle it,’” Lebowitz says. The program also works with parents to identify the ways in which they are accommodating anxious behaviors. “We’ll pick one thing that parents are doing that is an accommodation and help them make a detailed plan for how they’re going to change that,” Lebowitz explains. Treating Anxiety in Children and Adolescents Much of the existing research on SPACE has focused on parents of children under age 14. Ongoing studies are now exploring its use with parents of older teens. “Both anxiety and accommodation can interfere with normative developmental shifts during the teen years, including increased autonomy and individuation from parents,” says Rebecca Etkin, PhD, associate research scientist in the Child Study Center. “In this sense, SPACE may be particularly well-suited for anxious teens and their parents. We want to see whether it is effective during this distinct developmental window.” Unfortunately, many families in need of CBT face barriers, including limited availability of services and geographic constraints. One way to improve access is digital interventions. Silverman and her team are developing an evidence-based digitized intervention program for parents that they can access directly from their computer or smart phone. “The work we’re doing will be one of the very few parent interventions that is digitized and importantly tested for effectiveness,” she says. Creating interventions for anxiety-related challenges Silverman and Lebowitz recently received a generous gift to develop and test other interventions that help parents reduce other child anxiety-related behavioral and emotional difficulties, such as restrictive eating and unexplained somatic symptoms. One of these projects in particular focuses on understanding the risks of social media and its potential benefits, including offering a sense of connection. “A lot of research has focused on the idea that social media is harmful and the less of it the better,” says Lebowitz. “But we actually see is that this is not quite right—there are negatives, but there are also positives. So, we’re trying to get a little bit more nuanced of a picture.” The team is working with teens with social anxiety and their parents over an extended period to better understand their social media habits and how their anxiety levels affect engagement with different platforms. The teens will answer questions sent to an app on their phones about mood and social media usage in an effort to capture emotional responses as they unfold. “We hope to develop interventions that can help make the best of social media while protecting against the more problematic effects,” Lebowitz says. The brain’s role in anxiety Researchers are also testing therapies to address anxiety at the neurological and molecular levels. In collaboration with Dylan Gee, PhD, professor of psychology in Yale's Faculty of Arts and Sciences, and Hilary Blumberg, MD, John and Hope Furth Professor of Psychiatric Neuroscience at Yale School of Medicine, Lebowitz and Silverman are using brain imaging to identify changes in a child’s brain before and after parents enroll in SPACE. In one study, children viewed anxiety-inducing images while undergoing magnetic resonance imaging (MRI); the researchers conducted scans with and without the children’s parents nearby. Before SPACE, children’s brains were better able to activate the regulatory circuitry needed to turn off an anxious response when their parents were nearby. But after SPACE, children could activate this circuitry even without the parent around. “As parents work on gradually reducing some of their accommodations, you can see a child get better at regulating their own fear system in the brain,” Lebowitz says. “It’s remarkable.” Research into the molecular underpinnings of anxiety can also inform new childhood anxiety treatments. In a recent study, Lebowitz, Silverman, and Flora Vaccarino, MD, Harris Professor in the Child Study Center, discovered that a protein known as fibroblast growth factor 2 (FGF2) could be protective from the toxic effects of stress. FGF2 levels in children and their parents were linked to the children’s risk of developing anxiety and depression, the study showed. The findings could help explain why some children who are exposed to early life trauma such as poverty or abuse are more prone to developing mental health disorders. And FGF2 could be a target for treatment. “This is very novel because it starts to give a clue to what is the molecular chain that connects those lived experiences to the actual psychological outcomes,” Lebowitz says. New ways to study and treat childhood anxiety Michael Crowley, PhD, associate professor in the Child Study Center, collaborates with Silverman and Lebowitz to study the role that attention plays in development and maintenance of childhood anxiety. There is a large body of research that shows that anxious children, like anxious adults, are prone to focus on threatening stimuli such as angry faces compared with neutral faces. This has led to innovative interventions that involve attention retraining. The idea is that if experts train children to look away from threatening stimuli, it may reduce their anxiety—especially children with social anxiety who are most prone to attend to threats. The researchers have just completed a clinical trial for attention retraining with 10- to 14-year-olds with social anxiety disorders and are currently analyzing the findings. Besides this innovative attention retraining research, as Crowly notes, “I like to design tasks that are engaging to kids,” Crowley says. “My goal is to assess something without the kids knowing what we are assessing.” With this goal in mind, Crowley has created a virtual game, named Boom, to study threat processing in children with anxiety disorders. The game is similar to that of hot potato—the child and three digital players take turns virtually passing a ball to each other’s gloves. At some point, the ball turns into a bomb, and as the bomb lands in each player’s glove, the outline of the glove turns yellow. The goal is to avoid having the bomb go off in your glove. What isn’t obvious is that the game is designed to measure different types of threatening stimuli, both ambiguous and direct. In the game, the direct threat occurs as the bomb is traveling towards your glove. The ambiguous threat is the yellow outlined glove as it is unknown where the bomb will travel next. While children play the game, Crowley’s team measures their brain activity using electroencephalography (EEG). The researchers have discovered that in kids with anxiety, the brain reacts more strongly to ambiguous threats than it does in their peers, but less strongly to direct threats. They believe that the initial abnormally large brain response to not knowing where the bomb is going impairs the brain's ability to properly respond when the threat is actually traveling the child’s way. “The brains of children with anxiety are unable to differentiate between threats you need to do something about and those that are not your problem.” Michael Crowley, PhD, develops innovative games for studying anxiety in children and adolescents.Credit: Matt Bradbury Based on these insights, Crowley hopes to study whether interventions like attention training could restore appropriate threat processing. Crowley’s team is also working on a test called the Balloon Risk Avoidance Task, which evaluates risk-taking and avoidance behaviors. It features a digital balloon that is full of air and about to burst. Kids have six seconds to let air out of the balloon. The more air they let out, the less risk they face that the balloon will pop. But at the same time, the balloon becomes less valuable as it deflates. “The more air you keep in the balloon, the more points you get,” Crowley explains. So far, the researchers have found that when the balloons pop unexpectedly, teens with social anxiety show distinct brain responses. Studying these responses can help psychologists understand the underlying pathways driving the various manifestations of anxiety. The genetics of anxiety When Thomas Fernandez, MD, associate professor in the Child Study Center and of psychiatry, was still in training, there was a lot of excitement about understanding the genetics associated with autism spectrum disorder. Since then, scientists have identified around 250 genes associated with autism. The genetic contribution to anxiety disorders, on the other hand, has historically received less attention. Anxiety is less heritable than autism, but the genetic contribution for anxiety disorders that emerge in childhood may be higher than for anxiety disorders overall. While scientists estimate the heritability of anxiety disorders in general to be around 30% to 50%, some studies suggest higher heritability for certain childhood-onset anxiety presentations. “I saw firsthand how researchers in the field went about finding vulnerability genes for autism,” Fernandez says. “So, we’re using a very similar playbook for childhood anxiety.” “I saw firsthand how researchers in the field went about finding vulnerability genes for autism. So, we’re using a very similar playbook for childhood anxiety.” Thomas Fernandez, MD Associate Professor In the Child Study Center and in Psychiatry Now, Fernandez and Emily Olfson, MD, PhD, assistant professor in the Child Study Center, are studying children and their parents to identify genetic changes that are present in the child but not the parents, known as “de novo mutations.” “All of us have some de novo mutations—maybe about 50 to 100 sprinkled throughout the genome,” Olfson says. “But when they occur within the coding regions of genes, they can be really disruptive.” Previous research shows that people with autism have higher rates of damaging de novo mutations than the general population. In 2022, Olfson, Lebowitz, Silverman, and Fernandez published a study on 68 children and their families that found that children with anxiety had similarly high levels of these mutations. Studying de novo mutations can help point the researchers to where they should be looking for genes associated with anxiety. “The end game is using the genes to steer us toward the right part of biology that we can then target to come up with better treatments,” Fernandez says. Building on those findings, the team is now studying more families to better understand how these de novo mutations, along with other genetic and environmental factors, shape pediatric anxiety disorders. They recently received a National Institutes of Health grant to enroll 750 new families over the next five years. Olfson is the principal investigator, with co-investigators Lebowitz, Fernandez, Silverman, and Shuangge Steven Ma, PhD, department chair and professor of biostatistics at Yale School of Public Health. Neurodevelopment, Risk Genes, and Mental Health Conditions - The Olfson Lab Joel Gelernter, MD, Foundations Fund Professor of Psychiatry, is interested in how different anxiety disorders differ genomically. “We are studying social phobia, panic disorder, and generalized anxiety disorder, working to understand why people differ in their risk to these specific anxiety disorders and evaluating various risk factors,” he says. Gelernter was recently involved in one of the largest studies to date of the genomics underlying anxiety disorder. The study included around 122,000 people with anxiety disorders and around 730,000 without. It found that some genetic differences associated with anxiety were linked to signaling that helps reduce overactivity in the nervous system. Many anxiety medications available today work by targeting this process. “It’s nice when the biology that you get out of a large genome-wide study ratifies things that we already know because that can help increase confidence in further findings from the study,” Gelernter says. Uncovering the neurobiology of psychiatric disorders John Krystal, MD, Robert L. McNeil, Jr. Professor of Translational Research and chair of the Department of Psychiatry, is interested in the neurobiology of psychiatric disorders, including post-traumatic stress disorder (PTSD), of which anxiety is a major symptom. In the late 1980s, Krystal’s team discovered that the drug yohimbine activated symptoms in patients with PTSD. “This was the first time we could link a specific biological mechanism to the symptoms of PTSD,” Krystal says. At the time, he adds, this finding was highly controversial. “A lot of people felt that PTSD was a purely psychological syndrome that didn’t have an underlying biology.” Since then, Krystal has dived deep into understanding the neurobiology of PTSD to learn how to better treat it. His team is evaluating the use of ketamine and psychedelics. These would be among the first treatments to be developed specifically for PTSD. They may also be applicable for other disorders including anxiety disorders, Krystal adds. An important gap in PTSD treatment is the absence of biological tests that inform how to best help patients manage their PTSD symptoms. A doctor doesn’t diagnose cancer based on how they feel. Rather, they use tests of the biology of the cancer to determine the best course of treatment. “And we can’t do that in any psychiatric disorder other than Alzheimer’s disease,” Krystal says. “But now we are building a foundation for this approach to the treatment of anxiety disorders for the first time.” Source: Yale School of Medicine
Nintendo has renewed some classic game trademarks
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