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The Week in Business: D'Amico Hospitality's Next Chapter
This week’s top stories from Twin Cities Business.
DC Wrap: Supreme Courts rules on immigration and gun cases
A look at the day's biggest stories in national politics
Making Our Own Luck
We are cross-posting a piece that former NIH official Kris Willis wrote for Macroscience. Kris is now the President and Founder of the Woodley Park Institute, for which I’m a board member. Picking winners or hedging bets? Federal science agencies have long wrestled with the question of how to ensure their billions of dollars of grants and contracts result in maximum benefits for Americans. On the surface, it might seem that a goal-oriented, interventionist style of management would be the best policy: prioritize our most pressing problems and distribute funding accordingly.This top-down strategy creates a unique hazard, though: bad choices can send resources in the wrong direction, resulting in slow progress that impedes the delivery of tangible benefits to citizens. Moreover, if decision makers pursue an applied advance when the underlying scientific principles remain poorly understood, they risk costly failures and a loss of support for the research enterprise at large. Examples include Nixon’s 1971 War on Cancer, undertaken on the premise that a cure could be achieved in less than a decade, the drive to build an operational commercial fusion plant by the mid-1990s, and the National Plan to Address Alzheimer’s Disease, which failed to produce the effective treatments and prevention strategies promised by 2025. The contrasting laissez-faire approach is to hedge your bets. If the path to an advance is impossible to predict, then the wisest choice might be to distribute funding to as widely as possible. The main risk of this strategy is that spreading funding thinly may limit the resources available to the most promising research, resulting in the same negative outcomes as the interventionist approach: limited support for the most promising topics, slow progress, and delayed returns. In reality, at science agencies like the National Science Foundation and National Institutes of Health, program managers navigate between these two extremes, setting some funds aside to target high-priority areas and using the rest to cover the widest possible range of meritorious proposals. This middle path seems like the most rational way to proceed, but it still requires making choices. How much should be set aside for high priority topics? What should those topics be? How should we define merit? Expert opinion can provide a helpful guide, but leading experts can have remarkably different opinions about what matters and what should be prioritized. Moreover, experts and administrators alike can be risk averse, giving an edge to high-profile, well-established concepts. What’s really needed is a data-driven framework to help guide decision-making, one that doesn’t simply repackage prestige or incumbency. Recognizing breakthroughs years in advance Many breakthroughs fail to attract funding or recognition at the earliest stages of development. Katalin Karikó, for example, spent years struggling to win grants for work on mRNA that would eventually win her and Drew Weissman a Nobel Prize. Similar stories can be told about Jim Allison’s groundbreaking studies leading to the development of cancer immunotherapy, Stan Pruisner’s demonstration that prions can self-replicate without DNA, or Robin Warren and Barry Marshall’s proof that Helicobacter pylori, not stress, causes ulcers. Yet at some point, the scientific community recognizes and responds to transformative breakthroughs like these. How does that change happen? And what if science funders could identify the areas that are on the cusp of a breakthrough? Those questions led my collaborators and me to study how scientists responded to past breakthroughs. Based on patterns in that data, we developed a means of predicting future breakthroughs, using biomedicine as a proof of concept. It’s worth taking a moment to describe how our approach works. Briefly, our prediction process begins by grouping the 18 million or so peer-reviewed papers in PubMed, the authoritative database of biomedical research, into roughly 50,000 unique topics. A small subset of these topics are so widely acclaimed as breakthroughs that they have been recognized with a major prize like a Nobel or a Lasker Award. We theorized that studying the development of these outliers over time, especially before they gained acclaim, was the key to identifying future instances of them. After defining topics, we chose 21 representative breakthroughs and asked what they looked like before they won prestigious prizes. To answer that question, we re-ran our topic-mapping algorithm repeatedly, winding back the clock one year each time, stringing together the years to follow the progress of each field as it grew and advanced. We found that in each case, the years leading up to a discovery followed a pattern: a burst of papers on a new, rapidly evolving topic, many of which quickly became influential. These characteristics—the percent of papers that are new, the percentage of papers that are brought in from other topics, and the influence of each individual paper—can all be measured separately for any given topic. Together, they act as a predictive signal that is detectable an average of five years before a transformative discovery is made, and up to thirty years before the discovery receives a major prize. Scanning the current research landscape for topics that display this signal allows us to predict what work will likely produce a future breakthrough. Each year we analyzed includes four or five signals, a number that appears to have remained constant across a twenty year time frame. In their classic work on the sociology of science, Bruno Latour and Steve Woolgar established that the desire to participate in a major discovery is an important motivator for scientists as they consider whether they should take up (or abandon) a research problem. Although further work is needed, the simplest explanation for our results is that this behavior is widespread enough to detect at scale. A foundational advance, or something like it, draws the attention of scientists and causes them to change the direction of their research. They vote with their feet, staking their own reputation and careers by publishing on and citing the new idea. That upswell of interest is the foundation of our breakthrough signal. What kind of research does our model identify as a breakthrough? After building a model based on the patterns in our 21 preselected breakthroughs, we tested it by identifying all early signals of discovery from 1994 through 1997. Of the 18 signals we found in that time period, 17 can be traced forward in time to a breakthrough. Examples include super-resolution fluorescence microscopy (see the image above), the directed evolution of proteins and enzymes (Chemistry Nobel, 2018), and sequencing the human genome (National Medal of Science, 2008). The discovery of the role of leptin signaling in obesity is a particularly interesting case study. Around 1950, scientists noticed the existence of a type of lab mouse that suffered from a unique inherited form of obesity. When given the freedom to choose their own diet, these mice ate more than normal and preferred food that was high in fat. Researchers had few clues as to why the animals overate; early experiments pointed to the existence of a soluble ob factor found circulating in the bloodstream that regulated appetite, but its identity was unknown. In 1994, Jeffrey Friedman and colleagues identified and sequenced the ob gene, noting that the protein it encoded appeared to fit the profile of a circulating factor. A year later, a trio of high-profile publications demonstrated that ob was a hormone that regulated body weight and fat deposition by regulating appetite. One of these was co-authored by Friedman, who christened it leptin from the ancient Greek word for thin. Using our model, the data from 1996 make it clear this advance would become a breakthrough. Scientists had flocked to study the biology of the new hormone, generating the flurry of new papers and citations required to produce a signal. One of these demonstrated that serum leptin concentrations reflected the amount of adipose tissue in the human body, providing clinical validation of the earlier mouse studies. Before the identification of leptin, scientists were unable to point to a specific molecule that controlled appetite and adiposity, so that it was impossible to rule out non-physiological causes of obesity; its characterization fundamentally changed our concept of weight gain. In 2010, Friedman and fellow pioneer Douglas Coleman were awarded a Lasker for the discovery. Our work also identifies breakthroughs in clinical practice and behavioral and social sciences, even though these areas are less likely to draw the attention of major prize committees. One example that falls into this category is the introduction of endovascular aneurysm repair, a minimally invasive surgical procedure for the treatment of abdominal aortic aneurysm, a leading cause of death among Americans over the age of 65. Relative to the previous standard of care, it reduces in-hospital mortality by almost four-fold. In 2017, Timothy Chuter received the American College of Surgeons’ prestigious Jacobsen Innovation award for his multiple refinements to the technique. Another under-recognized breakthrough identified by our model is the development of standardized survey instruments to assess the quality of life for HIV+ patients. The antiretroviral cocktails introduced in the mid-1990s reduced AIDS mortality, but treatment came with serious side effects. The new evaluations showed that patients whose disease progressed had worse physical functioning than Americans with other chronic diseases, while those who were asymptomatic maintained a health-related quality of life on par with the overall US population. This evidence made it possible for patients and activists to argue that even in the absence of a total cure, and in spite of the side effects, alleviation of symptoms was a worthwhile priority for clinicians. My colleagues and I have failed to identify any significant recognition for the physicians and health policy experts who pioneered this advance, although in 2016, researchers called for the World Health Organization to set targets for good health-related quality of life as part of its framework to end the AIDS pandemic. From forecasting to funding How should science funders use our predictions? Any serious discussion of what we should do with this new capability needs to begin with an understanding of its limitations. We can’t (and shouldn’t) invest all of our resources in the small number of topics predicted to produce breakthroughs. Innovative new fields are born from existing ones; they rarely arise de novo. If funders don’t maintain a diverse portfolio, the breakthroughs of tomorrow will have no antecedents. Think of this as eating the seed corn, or killing the goose that lays the golden egg. There are also multiple goals of funding beyond basic scientific discovery, including translating discoveries into clinical practice, developing new technologies, supporting economic development, and training new scientists. The investments needed to accomplish these goals are likely different from those required to support emerging breakthroughs. Finally, we must be aware that we may not capture every instance of a breakthrough. The concept is fuzzy, and not every significant discovery is recognized with a major award. Further, breakthroughs are rare, meaning that our dataset is, by necessity, small. This makes formal estimates of accuracy challenging. Although our overall success rate appears to be high, any one signal may turn out to be a false positive. We found one apparent example: the development of the third generation COX-2 inhibitors, Vioxx and Celebrex, which were much celebrated in the early 2000s as effective but non-addictive pain relievers, meets all the algorithmic criteria of a breakthrough. Five years after it received FDA approval, researchers demonstrated that Vioxx was associated with serious cardiovascular complications, and the manufacturer voluntarily pulled the drug from the market. Celebrex remains available, although like other NSAIDs, it carries an FDA warning for increased cardiovascular risk. Decision makers who were overly focused on the breakthrough potential of this research might have wasted substantial resources nurturing an area that ultimately proved to be a failure—but so would those who relied on expert opinion at the time. That said, the potential benefits of funding the next mRNA vaccine or cancer immunotherapy years earlier than we might have are large. When we can’t assume the outcome of an action, it’s worth conducting an experiment. Can targeted support for areas that are poised to produce a breakthrough increase the return on scientific investment without cannibalizing future advances? With the necessary administrative infrastructure in place, conducting this experiment would be straightforward. First, identify all the breakthrough signals between 2018 and 2023, select half at random, and commit to a decade of investment. For biomedicine, a six year window should yield about 30 topics with the potential to produce a breakthrough. Providing strong support to half of these might be accomplished for $300 million a year. That’s roughly half of the recent annual budget of the NIH Common Fund or around 20% of the fiscal year 2025 budget for ARPA-H. After five years, then again at ten, compare to see which group — the one that was actively managed, or the control — produced more breakthroughs, and on what timescale. Although we used biomedicine as an example, the same experiment could just as well be run for physics, materials science, or any other discipline. Any attempt to undertake such an experiment should keep three points top of mind. First, we can predict the topic of future breakthroughs, but the people and vision for how to move the work forward are still important. In practice, this means success requires active program managers with the expertise to develop the science and the authority to do so, including by recruiting investigators. Second, we would be wise to learn from the failures of past attempts to fund transformative research. High among these are funding modestly repackaged work, confusing the genuinely novel with the merely unfamiliar, and relying too much on incumbent investigators. All of these risks can be mitigated by thoroughly and intelligently integrating high quality data into portfolio management. Finally, we need to have patience. Even with strong funding support, producing a breakthrough takes time. If supporting breakthroughs is the best way to nurture the birth of new fields, we also need to accurately describe and properly manage the other two stages, so that we invest wisely throughout the productive lifetime of ideas and divest once they reach the point of diminishing returns. We would benefit from more study of all of these phases, especially the transition from one to another. More research could answer questions like: When does a breakthrough become an established field? How do the availability of funding, the size and characteristics of the available workforce, and the accumulation of evidence that disagrees with prevailing models affect a field’s decline? Exactly how do old ideas give birth to new ones, and can we speed up the process? The more we understand about the dynamics of scientific progress, the better we can maximize the odds that our curiosity leads to results. I’d call that finding a way to make our own luck.
2-RBI days from Henry Davis, Brandon Lowe lead the Pirates to a series win against the Mariners
The Pirates continually walked a tightrope. The Seattle Mariners never let them fall. The Pirates beat the Mariners 5-1 on Thursday afternoon at PNC Park...
Short-form science: University of Washington researchers launch PaperTok to combat AI slop
A University of Washington team is helping scientists tell their own stories with a free tool that converts dense, jargon-heavy publications into short, accessible videos.
The science of fatherhood from brain changes to ‘dad bod’
Darby Saxbe’s book combines academic data with ‘stories about the men in her own life’
Another look at carrots and eyesight; how to get more fiber; why mosquitoes bite some people and not others; plus other stories with Vanderbilt Health sources
AARP reporter Stacey Colino interviewed Milam Brantley, MD, Associate Professor of Ophthalmology and Visual Sciences, in 2020 for a story about whether eating carrots can improve vision. Sacramento Bee reporter Samantha Agate has now used Brantley’s comments in an AI-curated story created by content specialists on the same topic that has been picked up by MSN and others. Prevention magazine interviewed Heidi Silver, RD, PhD, Founding Director of the Vanderbilt Diet, Body Composition, and Human Metabolism Core, for a story about the importance of fiber and how people can get more of it in their diet. William Schaffner, MD, Professor of Preventive Medicine, was quoted by several news outlets about public health issues, including: Women’s Health (tick bites and alpha-gal syndrome); The Washington Post (tetanus); and Healthline (why mosquitoes prefer to bite some people and leave others alone). A visit to Monroe Carell Jr. Children’s Hospital at Vanderbilt by some Banana Ball baseball players was covered by The Tennessean and WZTV Fox 17 News, and The Tennessean’s story was also picked up by Yahoo! Sports. Clarksville Now published a story written by the Montgomery County Economic Development Team, whointerviewed Bradley Stancombe, MD, professor of Clinical Pediatrics, Vanderbilt Neonatology, about the new energy of Vanderbilt Clarksville Hospital and how the facility is recruiting physicians. Healio Allergy/Asthma group editorial director Richard Gawel interviewed Mark Rolfsen, MD, Clinical Fellow in the Division of Allergy, Pulmonary and Critical Care Medicine, for a story about his presentation at the American Thoracic Society meeting on metal health outcomes following ICU discharge. Nashville Scene reporter Hannah Herner interviewed James Crowe, MD, Director of the Vanderbilt Center for Antibody Therapeutics, for a story about his efforts to prepare for the next pandemic by isolating antibodies that can neutralize dangerous viruses. Medscape reporter Kathleen Doheny interviewed Neesha Choma, Associate Chief of Staff of Vanderbilt University Hospital, for a story about how hospitals can reduce readmissions.
Scientists measure hidden quantum forces that could power a new generation of pharmaceutical drugs
Researchers invent a laser technique that reveals the hidden forces shaping proteins, advancing a future of precision medicine engineered with quantum precision.
Trump news at a glance: US president holds a rare bipartisan bill hostage
Trump says he’ll sign housing bill aimed at lowering costs only after Senate passes restrictive voting measure – key US politics stories from Wednesday 24 June at a glance
4 years after Dobbs, Texas abortion rights advocates share personal stories
In June 2022, the U.S. Supreme Court overturned Roe v. Wade, ending the constitutional right to an abortion
Pa. measles cases jump, spread to Northumberland County
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DC Wrap: Trump lashes out over Iran vote; Great American State Fair begins
A look at the day's biggest stories in national politics
DC Wrap: Trump lashes out over Iran vote; Great American State Fair begins
A look at the day's biggest stories in national politics
Noah Hiles: These Pirates don’t deserve to be buyers at the MLB trade deadline
I’ve long believed the MLB standings aren’t worth viewing until Memorial Day. With the regular season being such an extended grind, the first...
The US in Brief: A big night for Zohran Mamdani
Our daily political update, featuring the stories that matter
NBC News - Breaking Headlines and Video Reports on World, U.S. and Local Angles
Go to NBCNews.com for breaking news, videos, and the latest top stories in world news, business, politics, health and pop culture.
DC Wrap: Senate OKs war powers resolution; Iran contradicts U.S. on inspections
A look at the day's biggest stories in national politics
DC Wrap: Senate OKs war powers resolution; Iran contradicts U.S. on inspections
A look at the day's biggest stories in national politics
The US in Brief: Two court setbacks for Donald Trump
Our daily political update, featuring the stories that matter
Sporticast: Why Netflix, EA Have Their Own World Cup Games
On the 563rd Sporticast episode, hosts Jacob Feldman and Justin Birnbaum discuss some of the biggest sports business stories of the week, including a detailed breakdown of Netflix’s FIFA World Cup video game. Following Electronic Arts and FIFA’s split in 2022, both parties now have World Cup-related offerings on the market. Electronic Arts recently launched …
DC Wrap: Vance claims progress in Iran talks; Reflecting Pool being repaired
A look at the day's biggest stories in national politics
KSU master’s graduates benefit from NIH-funded bridge program
Recent Kennesaw State University graduate April Ford engaged in a program designed to help master’s students in the College of Science and Mathematics gain the experience they needed to pursue doctoral degrees elsewhere. She’ll stand as an example of the Peach State Bridges to the Doctorate program’s effectiveness, having earned her Master of Science in Integrative Biology (MSIB) and acceptance into a Ph.D. program. Ford, Jojo Croffie, and Lindsey Knight all earned their MSIB degrees, and thanks to enrichment through the Peach State Bridges to the Doctorate program, each will start a Ph.D. in the fall.
CIBC US Faces of Impact Chicago Affordable Housing
Since 2014, CIBC has been financing affordable housing initiatives in Chicago to strengthen neighborhoods and make a difference in communities that need it the most. As of publication, more than 50 structures have been completed from West Ridge to Calumet Heights, each with a unique story. Faces of Impact highlights three of those stories, and the people behind them driving safe and accessible housing.
Rams news: No felony charges, potential breakout player and more
Some stories about the NFC West rival LA Rams from the last week for Arizona Cardinals fans to know.
Seahawks news: Breakout candidates, top 100 lock, more fullback
Some stories about the NFC West rival Seattle Seahawks from the last week for Arizona Cardinals fans to know.
49ers news: Mike Evans impressing, rookies who impressed
Some stories about the NFC West rival San Francisco 49ers from the last week for Arizona Cardinals fans to know.
Driver fleeing from police crashes into South Side business
A man wanted for robbery and domestic violence fled from police Saturday evening, crashed his vehicle into a business and then escaped pursuing officers...
Beyond the World Cup... 5️⃣ stories shaping Sunday
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New steps lead to a major renovation on the Ligonier home tour
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Dirt on Dirt - Salina gives Davenport another MLRA sweep
DirtonDirt.com covers Dirt Late Model racing like no other publication, magazine or website with massive amounts of original content including videos, photos, stories, columns, blogs and more. Eldora Speedway's World 100 and Dream, the Dirt Track World Championship, Lucas Oil Late Model Knoxville Nationals and all the major races are covered along with the major tours, including the World of Outlaws Late Model Series and Lucas Oil Late Model Dirt Series.
Beyond the World Cup... 5️⃣ stories shaping Saturday
The national football scene is boiling over this Saturday with an explosive mix of boardrooms, asphalt, and grass. While the LALIGA EA SPORTS transfer market begins to stir with strategic moves in the...
From $500 to $1tn: How Elon Musk built his fortune
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DC Wrap: Vance delays Iran talks trip; Trump unveils new Air Force One
A look at the day's biggest stories in national politics
DC Wrap: Vance delays Iran talks trip; Trump unveils new Air Force One
A look at the day's biggest stories in national politics
The US in Brief: Meet America’s next socialist mayor
Our daily political update, featuring the stories that matter
Sports quiz of the week: World Cup, US Open, Wimbledon and Royal Ascot
Have you followed the big stories in football, cricket, golf, tennis, athletics, rugby union, horse racing and MMA?
The Week in Business: Is It Time to Tear Down Empty Skyscrapers?
This week’s top stories from Twin Cities Business.
DC Wrap: Oil tankers begin to move in strait; Obama celebrates center opening
A look at the day's biggest stories in national politics
Inside H2PNIL: How Pitt's battle to keep Mason Heintschel led to Allen Greene's new fundraising platform
Heading into the offseason, Pitt faced a challenge keeping its starting quarterback, Mason Heintschel. The star freshman led the Panthers to a 6-3 record...
The unwanted return of tetanus; why soccer makes people so happy; breast cancer in men; plus other stories with Vanderbilt Health sources
Women’s Health interviewed Kathryn Edwards, MD, Sarah H. Sell and Cornelius Vanderbilt Professor of Pediatrics, for a story about her JAMA Viewpoint article on tetanus making a comeback. Women’s Health interviewed Colin Armstrong, PhD, Assistant Professor of Clinical Psychiatry and Behavioral Sciences and Assistant Professor of Physical Medicine and Rehabilitation, for a story tied to the World Cup about why soccer makes people so happy. An NBC News story about the announcement by “X-Men” actor and former wrestler Tyler Mane that he has breast cancer quotes Ben Ho Park, MD, director of the Vanderbilt-Ingram Cancer Center. The story focuses on how a prominent man with breast cancer may help remove some stigma from a cancer that is rare in males. Prevention magazine interviewed Caitlyn Mooney, MD, Assistant Professor, Department of Orthopaedic Surgery, for a story about a BMJ study that suggests 90 to 120 minutes per week of strength training may lower the risk of death. William Schaffner, MD, Professor of Preventive Medicine, was quoted by several news outlets about public health issues, including: Women’s Health (norovirus is more common this summer); SFGate (measles in San Francisco just before the World Cup crowds); Travel + Leisure (how to avoid getting sick on a cruise); and Fox News (mosquito-borne diseases). Reporter Liz DeSantis from WKRN News 2 aired a story on the rehab unit at Monroe Carell Jr. Children’s Hospital at Vanderbilt. Kat Hedden, PT, DPT, PCS, CBIS, Acute Pediatric Physical Therapy Clinical Team Lead and Mary McLanahan, MD, Assistant Professor of Physical Medicine and Rehabilitation were interviewed, as well as the family of patient Will Terry. Reporter Nikki Hauser from WTVF News Channel 5 interviewed Graden Knapp, Gaming and Technology Specialist at Monroe Carell Jr. Children’s Hospital at Vanderbilt about his 3-D wheelchair project. Tennesseanreporter Sandy Mazza covered the announcement of the latest Leadership Nashville class, which includes Jane Freedman, MD, Deputy CEO, and Chief Health Systems Office for Vanderbilt Health; and also the announcement of the latest Leadership Tennessee cohort, which includes Jeff Upperman, MD, Surgeon in Chief at Monroe Carroll Jr Children’s Hospital at Vanderbilt.
What we observed as the Pirates played the A's in a (surprisingly pleasant) minor league ballpark
WEST SACRAMENTO, Calif. — I hadn’t even made it inside Sutter Health Park when someone asked me what I thought of the stadium. Those conversations...
Six of the biggest health news stories today
High-end infant formula scrutiny, the spread of synthetic opioids, and more health news from Morning Rounds
🥐Bernardo, Víctor Muñoz and more... the day's 5️⃣ stories
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Small Business Owner and Former Cultural Affairs Commissioner Jeannine Wisnosky Stehlin Launches Bid for Culver City Council
Small Business Owner, Former Cultural Affairs Commissioner, and longtime community volunteer Jeannine Wisnosky Stehlin today declared her candidacy for the Culver City Council. Wisnosky Stehlin is running to be a voice for residents and community members who want strong, collaborative leadership at City Hall. "People come to Culver City because the...
DC Wrap: Iran deal details emerge; Trump stalls his own intel pick
A look at the day's biggest stories in national politics
DC Wrap: Iran deal details emerge; Trump stalls his own intel pick
A look at the day's biggest stories in national politics
Noah Hiles: What happens if the Pirates don’t improve? Ben Cherington should hope we don't find out
It’s been a rough June for the Pirates. Don Kelly’s club entered Wednesday with a 5-9 record on the month. A few of their recent victories...
The US in Brief: Trump gets bruised in the Peach State
Our daily political update, featuring the stories that matter
Letter to the editor: Allegheny County must stop chasing businesses away
Allegheny County’s leaders have spent decades perfecting the art of driving away the very people and businesses that fund their salaries. They didn’t...
Mental Health Can Complicate Family Planning
Five stories show the hurdles that people with psychological diagnoses face when considering parenthood.
Board recommends sheriff changes, 40-year business closes among top TNT stories
Also Tuesday, the latest restaurant inspections and The News Tribune’s food writer offers her thoughts on Knapp’s demise.
Wales' papers: New move to curb use of phones and science teaching under fire
A review of the front page stories from the daily and weekly newspapers in Wales.
Free World Cup tickets, new Whole Foods, top Miami mall. See top business stories
Here’s what to know.
Politics News: Latest on Trump Administration, Congress, Elections and More
Find the latest political news stories, photos, and videos on NBCNews.com. Read breaking headlines covering Congress, Democrats, Republicans, and more.
What's the average age of first-time homebuyers across Europe?
Fewer than seven in ten EU households live in owner-occupied homes. Euronews Business takes a closer look at the age at which Europeans buy their first home, which varies widely across the continent, based on exclusive data provided by RE/MAX.
The Newest UFC Fighting Game Is Great at Telling Stories, but One Big Change Also Means It Strays Further Than Ever From the Actual Sport
An impressive fighting game that strays further than ever from the sport’s reality.
DC Wrap: U.S. and Iran agree to end war; Trump arrives at G7
A look at the day's biggest stories in national politics
DC Wrap: U.S. and Iran agree to end war; Trump arrives at G7
A look at the day's biggest stories in national politics
Bagwell College of Education hosts 2026 Georgia Elementary Science Olympiad
Kennesaw State University’s Clarice C. and Leland H. Bagwell College of Education recently welcomed nearly 1,300 elementary school students representing 63 schools for the Georgia Elementary Science Olympiad State Tournament.
Prosper Kpotufe: Pursuing computer science while building community
Prosper Kpotufe keeps going. The doctoral student is an Orr Fellow and software engineer at The MJ Companies, with experience at Johnson & Johnson, PPG, Fastenal Company, American Chemical Society and…
A new chapter begins for Football Italia
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Cucurella, Rashford... 5️⃣ stories beyond the World Cup
The summer transfer market exploded completely this Monday, stealing the spotlight from the World Cup itself for a few hours. Clubs from Europe’s top leagues don’t want to waste any time, and the ...
Fly around the globe with Google Earth’s new flight simulator
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Why businesses are concerned about Allegheny County's proposed paid leave policy
Meredith Boyle is one of hundreds of small business owners concerned about how to cover the costs of paid parental leave if Allegheny County eventually...
Famitsu review scores - June 13, 2026 - first score for The Adventures of Elliot: The Millennium Tales
The latest Famitsu review scores for the week of June 13, 2026 are as follows: 007 First Light – 9/9/10/9 The Adventures of Elliot: The Millennium Tales – 8/8/9/8 Unrailed 2 – 9/8/9/7 World of Tanks: Heat – 8/7/8/8 Isekai Villain – 7/7/8/8 Inkonbini: One Store. Many Stories – 6/7/8/8 Note that for each review, four editors gave out scores....
Here’s what you missed: A week of big announcements in politics and law enforcement
It was a busy week across the Upstate, beginning with Primary Election Day and ending with some notable arrests and convictions. Here are some of the major stories you may have missed from this week.
Why Paul Skenes, at the center of the MLB's labor battle, believes the players need to dig in
When it comes to negotiations for the MLB’s next collective bargaining agreement, there are some misconceptions that Paul Skenes would like to clear...
New housing, higher costs, expanded bakery. See top Miami-area business stories
What to know about spending your money in South Florida.
DC Wrap: U.S. and Iran have apparent breakthrough in talks
A look at the day's biggest stories in national politics
DC Wrap: U.S. and Iran have apparent breakthrough in talks
A look at the day's biggest stories in national politics
Star Spangled Stories: The 50-year history of the Maryland Science Center
10 things we learned about Mike McCarthy and the Steelers during spring workouts
Aaron Rodgers reported early for the voluntary portion of the Steelers’ offseason workouts. Other star players who might typically skip OTAs also...
Doctor, former cancer patient share stories amid focus on men's health
Doctor and former cancer patient share stories amid focus on men's health
As Affordable Care Act premiums skyrocket, catastrophic coverage is having a moment
Jason Miller watched his monthly health insurance premiums quadruple to $374 from $80 for a silver-level plan when the Affordable Care Act’s enhanced...
CMS Moratorium Could Spur Hospice, Home Health M&A
A current moratorium on home health and hospice Medicare enrollment could increase demand for mergers and acquisitions in the short term. The U.S. Centers
Panthers are telling the world's biggest sports stories at FIFA World Cup 2026
Meet a few of the students and alumni covering the FIFA World Cup for top organizations.
Sports quiz of the week: World Cup, Knicks, T20, Giro and Serena Williams
Have you followed the big stories in football, cricket, cycling, tennis, motor sport, basketball and athletics?
Protecting health after earthquakes: learning from a community-centred approach in Türkiye
In the hours and days after an earthquake, communities face devastating loss, displacement and profound disruption of daily life. In the weeks and months that follow, new health risks can quickly emerge that compound the immediate impacts. These continue to evolve over time.
The Week in Business: Christophe Beck's Call to Kickstart Minnesota's Economy
This week's top stories from Twin Cities Business.
DC Wrap: Trump cancels Iran strikes and reveals his intel chief pick
A look at the day's biggest stories in national politics
5 great action movies on Netflix that are perfect for the summer
From globe-trotting spy thrillers and futuristic battles to inspiring underdog stories, these Netflix action movies deliver the kind of excitement, spectacle, and entertainment that summer was made fo...
Why Do Chatbots Keep Telling Stories About Someone Named 'Elias Thorne'?
Chatbots just aren't very creative.
Using AI for medical advice; pelvic floor exercises; the hidden dangers of burning incense; plus other stories with Vanderbilt Health sources
Colin Walsh, MD,Associate Professor of Biomedical Informatics, was on WTVF News Channel 5‘s “Morningline” show in an interview about whether or not it is safe to use AI for medical advice. Time magazine reporter Stacey Colino interviewed Elisabeth Sebesta, MD, Assistant Professor of Urology, for a story about pelvic floor exercises for issues including menopause, erectile dysfunction and urinary incontinence in men. “Each Breath,” published by the American Lung Association, quoted Brian Christman, MD, Adjunct Professor of Medicine, for a story about the hidden dangers of burning incense. William Schaffner, MD, Professor of Preventive Medicine, was quoted by several news outlets about public health issues, including: Healthline (low vaccination rates lead to more cases of measles, whooping cough and other preventable diseases); ABC News (U.S. measles cases surpass 2,000 for second year in a row); and CIDRAP News (high-dose flu shots cut rates of hospitalization in older adults). Sarah Rohde, MD, Associate Professor of Otolaryngology-Head and Neck Surgery, was quoted in a People magazine story on patient Makalii Andrade, a surfer from Kauai Island who suffered a serious neck injury in 2022 and recently underwent surgery at Vanderbilt Health to begin the final phase of his recovery. James Crowe, MD, Director of the Vanderbilt Center for Antibody Therapeutics, for a piece in Nature about antibodies against a strain of Ebola. SFGATE reporter Gillian Mohney interviewed Xue Zhong, PhD, Research Assistant Professor, Division of Genetic Medicine and Clinical Pharmacology, for a story about a study of a blood test looking at Alzheimer’s disease biomarkers. Matthew Franklin Mart, MD, Assistant Professor of Medicine, was quoted in a Healio story about how inflammation and illness severity is linked to less cognitive resilience after a person has been an ICU patient. The “How We Really Feel” podcast host Sula Windgassen, PhD, interviewed Lindsey C. McKernan, PhD, MPH, Associate Professor of Psychiatry & Behavioral Sciences, Physical Medicine & Rehabilitation and Urology, for an episode focusing on pelvic and bladder health. The podcast is also available on YouTube and the podcast website. In addition, podcaster Monica Sanford interviewed cardiologist Mark Glazer, MD, for her podcast “The Monica Sanford Show”; the two-part interview is here and here.
Chatbots Keep Telling Stories About Lighthouse Keeper 'Elias Thorne'. We Might Know Why
LLMs including ChatGPT, Gemini and Claude are obsessed with telling stories about lighthouse keepers and clockmakers, and one character named 'Elias Thorne' has made his way from chatbots to Amazon books. Researchers are trying to discover why.
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New small businesses are emerging with innovative ideas and a passion for excellence. This column highlights their unique offerings and inspiring stories, showcasing the creativity and resilience of entrepreneurs shaping our communities. Jonathan Palk, managing associate for Peachtree Planning, is highlighting local businesses through in-person podcasts. “The purpose of the podcast is to share stories […]
The Health and Wellbeing of Formerly Incarcerated People in Connecticut: Insights from the DataHaven Community Wellbeing Survey
By Carter Shannon, Nat Markey, Nora Hodgson, Samantha Lydell, Andrew Carr, and Mark Abraham, DataHaven About this Report Approximately 1 in 5 men aged 18–64 in Connecticut have experienced incarceration at some point in their lives. This population includes people who have been held in a local jail for a single night and those who have served lengthy prison sentences, and it cuts across race, age, geography, and socioeconomic background in ways that reflect broader structural inequities in the criminal legal system. Yet across nearly every indicator of wellbeing, formerly incarcerated people in Connecticut face significant disparities compared to those without an incarceration history. This report explores data on the experiences of formerly incarcerated men in Connecticut from the DataHaven Community Wellbeing Survey (DCWS). The DCWS illuminates significant gaps in economic wellbeing, physical health, mental health, and social support between men with and without incarceration histories in Connecticut. The survey also reveals worse self-reported outcomes for formerly incarcerated people across a range of quality-of-life indicators, with disparities that are often most severe among those who have been incarcerated more than once. These disparities do not arise by chance. They are shaped by a policy landscape that erects lasting barriers to housing, employment, and healthcare for people leaving incarceration, as well as by the physical and psychological toll of incarceration itself. This report is being written in the political context of federal funding cuts to social programs and proposed rollbacks to Medicaid eligibility, changes that will disproportionately impact people with incarceration histories, who are more likely to rely on public health coverage and other safety net supports.
‘Seattle: A History in Short Stories’ captures city’s fascinating past
The three-episode “Seattle: A History in Short Stories” concludes with its final episode on Tacoma’s KBTC-TV on Thursday (and streams next day at kbtc.org).
Discover this week's must-read health stories
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Texas A&M advocates nutrition education for tomorrow’s nurses
The Nutrition-to-Nursing pathway provides a deeper understanding of the biological systems that underpin health and disease.
New OMB rule could break science in the United States
The drug that saved your mother. The treatment your doctor recommended. The clinical trial that bought someone you love more time. None of it was inevitable. It required a system built to operate outside politics and sustained over decades, because science doesn’t operate on the timeline of a politician. That system is now under direct threat. The Office of Management and Budget (OMB) has proposed a new rule to regulate all federal grants, not just science, but housing, education, defense, NASA and everything in between, that would fundamentally change how research is conducted in the United States. There have been a lot of fires in the past 16 months, and if everything is an emergency, nothing is an emergency. But this is a very big deal. These rules would strip away the independence that has kept science from becoming a political tool. The good news is there’s still something we can all do. How the grant system was designed to work When I was a new faculty member, I was full of millions of ideas, so I sat down and wrote an NIH proposal. I worked on it for months and thought it was so good. Then I sent it to my mentor. It came back covered in comments. Places where my reasoning wasn’t as airtight as I’d thought, methods that could be stronger, gaps in my thinking that I had been too close to the work to see. It stung, as honest feedback always does, but peer review almost always makes the work better. In fact, it’s the backbone of how American science has functioned for generations. At NIH, submitted proposals go to a panel of scientists who have experience in the field. These are the people who can read research methods and spot their weaknesses, who understand when an experiment is designed well and when it isn’t. Applications are scored rigorously, and often only the top 3-20% of proposals receive funding. The people making funding decisions are required to justify them based on these reviews. To be clear: this is not a perfect system, and good science still goes unfunded more often than any of us would like due to limited resources. There is also criticism that peer review may undervalue bold ideas that are risky but could have high payoffs. But the peer review system is nonetheless a meaningful part of the grant selection process. While thoughtful and careful changes could improve the system, the changes being proposed by OMB will not make things better. The rule that could change everything Through this OMB proposal, the system that helps decide what gets funded is being dismantled. There are many troubling elements buried in this proposal, but three provisions stand out in particular. Each would be damaging alone. Together, they would change what kind of science gets done in America, and who it serves. 1. Political appointees would decide which science gets funded, and peer review would be explicitly sidelined or ignored. The guidelines your doctor follows, the standards that determine what’s in your air and water, the drugs that get approved for your family: all of it starts with a funding decision. Right now, that decision is made by scientists who can evaluate whether the work is actually sound and whether it could move the needle forward. Under this proposal, funding decisions could be made by political appointees. The careful, expertise-driven review process that shapes grant funding would be effectively sidelined. That means that a poorly designed study could get funded simply because someone in a political office liked the sound of it, while rigorous, important work doesn’t get funded because it no longer aligns with the administration’s priorities. In other words, critical work that benefits all of us could now be missed just because it has become politically inconvenient. 2. Grants could be canceled at any point, without warning, in the middle of ongoing work. Say your tax dollars have been paying for a cancer study for two years. The grant was awarded for five years, so the team is mid-experiment. There are three additional years’ worth of answers that could change how the disease is treated for hundreds of thousands of people. With this new rule, the federal government could cancel the remaining funding tomorrow, walk away from the commitment it made with your money, and have no legal obligation to finish what it started. This is a huge waste of money. There are rarely other sources of funding for this work, which means the team, the graduate students, postdocs, and research staff who have dedicated years of their careers to this project could lose their jobs. Patients who have contributed their time to studies may not see it turn into useful learnings for others. Every hour of work already completed could result in nothing useful. Science can take decades to get to tangible outcomes. It needs a stable funding system to flourish. 3. Researchers would have a harder time communicating their findings without pre-approval from the federal government. There is a saying from Sir Mark Walport: “Science isn’t finished until it’s communicated.” Science is no use to anyone if it is kept locked away in the labs that produced the data. The proposed rule could make communicating research findings harder in a number of ways: Make it harder for scientists to widely share their findings in scientific journals. Publication costs, including journal fees that allow for broad public access, could not be paid for by federal funds which is often how scientists pay these costs. Restrict researchers from engaging publicly about how their findings should inform policy or public health guidelines. This would restrict scientists from doing the work that transforms years of lab work into decisions that actually affect people’s lives. Make it harder for scientists to attend conferences. Conferences would now need to be approved by the federal agency at the time of grant award. This disadvantages conferences or publications that are not politically aligned. Conferences are a key way in which scientists learn about work happening in their field so they can collaborate and build on each other’s findings. What good is science with a muzzle? The long-term impact These changes could (and hopefully would) be reversed under the next administration. But by then, damage has been done. Once projects are halted or denied funding by political appointees, people leave their science careers for other paths or even leave the country to do their amazing science elsewhere. You cannot pause a scientific study the way you pause a subscription you decided isn’t useful anymore. You cannot freeze a research team that depends on salaries to feed their families, causing a scramble for replacement funding that, in most cases, simply does not exist. When the money stops, everything stops, and all the work in progress and its potential are lost. Despite all of the language about reducing waste, fraud, and abuse, this new proposed rule increases the administrative burden tremendously. Every researcher watching this unfold will make a rational decision: don’t start anything that will take a decade to finish. This includes not building a team around funding that could vanish, or asking the big questions that need patience and stability to answer. The most consequential science, the kind that produces the treatments and the breakthroughs that reach your doctor’s office twenty years from now, is exactly the science that would be abandoned first. This is still a proposal, so we can all do something Some worry this rule is already a done deal. But by law, OMB is required to open a public comment period. Those comments matter because they inform members of Congress, they can be used in litigation, and they create a public record. So here’s what you can do: Submit a public comment. The public comment period on this proposed change is open until July 13. Anyone can submit a comment, and OMB is required to respond to substantial ones. Each comment must be different to count as distinct; identical comments will be counted only once. Comment as an individual, not on behalf of your organization. Here’s a full resource to help you, with useful examples, but in general: Share a story about how science or federal funding has benefitted you or is involved in your work. Are you or someone you loved a cancer survivor? Do you know someone with Alzheimer’s? Have you received NIH/NSF or other federal funding? All of these can be stories you use to highlight why you care. Explain why you’re worried about these proposed changes. You can use the wording found here or in other resources to help you. Ask them to withdraw this proposed rule. Contact your elected representatives. Congress allocates money to federal agencies to spend, and it has oversight of how that process works. You can let your representatives know this proposed change concerns you and ask them to intervene. There are levers they can push that can help at this moment. Let others know why federal funding matters. This isn’t just about science, but ALL federal grants, including for education systems, defense projects, and more. The process, including the importance of federal funding, is invisible to many. We can all make it more visible by sharing how science benefits us and why we value it. You can also share this article, or any of the resources linked here, to help spread awareness! Bottom line We are quickly losing ground in scientific research in the U.S. More changes, like the proposed rule by OMB, would decimate our ability to conduct research here, leaving us all worse off: fewer treatments for pancreatic cancer, less research on pollution impacts, fewer answers for patients with rare disease, and more unaddressed health needs. The impact will be very real for all of us, regardless of where we stand politically. Using our voices for science is more important than ever. Love, LM Big thanks to Dr. Megan Ranney for reading this over and providing brilliant insights, as always. Dr. Liz Marnik, PhD, is Executive Director of The Evidence Collective at YLE and a science communicator and immunologist working at the intersection of public trust, science, and public health. You can find her on Substack, LinkedIn, Instagram and Threads. Your Local Epidemiologist (YLE) comprises a team of experts, ranging from physicians to immunologists to epidemiologists to nutritionists, working together with one goal: to “Translate” ever-evolving public health science so that people are well-equipped to make evidence-based decisions. The YLE suite of newsletters reaches over 475,000 people across more than 132 countries. This newsletter is free to everyone, thanks to the generous support of fellow YLE community members. To support the effort, subscribe or upgrade below: Subscribe
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