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N.Y. lawmakers renew push for rural suicide prevention council after Hochul veto
The council would be tasked with identifying barriers to mental health and substance use treatment in rural New York.
The Science Behind TIL Therapy and Its Potential Impact on Cancer Treatment - City of Hope
The Science Behind TIL Therapy and Its Potential Impact on Cancer Treatment - City of Hope / Alexandra E. Rojek, cancer, City of Hope, Cristina O’Donoghue,
White House chief of staff Susie Wiles announces she is cancer free
White House chief of staff Susie Wiles announced Wednesday that she is cancer free, sharing the news in a post on social media and thanking President Donald Trump for his support throughout her treatment.
What Does the Science of Climate Change Really Look Like?
Editor’s Note: This is the second in a three-part series on how the Right should think about environmental and climate policy. Read Chris Barnard on Reclaiming Environmental Policy from the Left. More than a decade ago, the world’s governments negotiated and signed the Paris Climate Agreement, committing to hold global warming well below 2 degrees Celsius. In the following years, climate had immense cultural power. Greta Thunberg emerged. Fortune 500 companies established net-zero plans. The U.S. got the Inflation Reduction Act. Then the pendulum swung back. President Donald Trump returned to the Oval Office, speaking of green energy as a “scam” and carbon footprints as a “hoax” and on all matters of international policy emphasizing bilateral engagement and power over globalism and cooperation. The technology companies that had been at the forefront of net-zero pledges and green leadership discovered the importance of all-of-the-above power to their visions for artificial intelligence and began quietly postponing or removing their targets. On the left side of the political spectrum, rising concerns about inflation and cost pushed climate lower down in the stated priorities of voters and stump speeches of politicians. The moment is ripe for a reset on the politics of climate change and for conservatives especially to chart a course that acknowledges and addresses the real challenges in plausible ways. So what should we think about climate change as we enter a post-peak climate era? If it is neither an apocalypse nor a hoax, what will hold up as a durable view of climate change? And how does it project onto the concerns and priorities of the right-of-center’s emerging coalition? New to Commonplace_? Subscribe below to get the magazine in your inbox._ Subscribe A Solid Foundation As the politics and economics of climate careened over the past ten years, the physics carried on regardless. In 2015, the year the Paris Climate Agreement was adopted, the world emitted 41.2 gigatonnes of carbon dioxide. By 2025, emissions had risen only 2.4%, to 42.2 gigatonnes, because falling emissions from land use offset increasing emissions from fossil fuels. But slow growth in annual emissions is not rapid decline, let alone net-zero, so carbon dioxide kept accumulating in the atmosphere, going from 399 to 426 parts per million. Global temperature kept rising too, from about 1.1 degrees Celsius above the 1850–1900 average in 2015, to 1.4 degrees above it in 2025. None of this should surprise anyone. Even most prominent skeptics, like the authors of the 2025 report commissioned by the Trump administration’s Department of Energy, accept the basic physics. Carbon dioxide added to the atmosphere at industrial volumes accumulates and traps heat that would otherwise escape to space. That heat warms the upper ocean and increases temperatures at the surface. Increased ocean heat and melting of land ice cause sea levels to rise. Changes in the climate become noticeable to us as subtle shifts in temperature and precipitation, seasons arriving early or late, changes in the surrounding ecosystem, and weather extremes. The much more meaningful debate is not about whether these things are happening, but about what it all means for human societies. (While it is a proxy measure of overall risk, no one experiences global surface temperature.) This debate invokes at least three interesting questions: how much today’s warming is showing up in regional climate trends, how much more warming we should anticipate, and how extreme weather events can be understood in the context of climate change. Recent scientific advances give us new insights into each of these, but there is still much to learn. This is the context in which the next generation of conservative leaders will be the first to deal with significant climate change as a fact, not a forecast. It will be with them for their entire careers. Our evolving scientific picture of climate change will come from weather and climate records stretching further into the past, new kinds of observations in the present, better modeling tools for the future, and simply more time to observe the emergence of climate signals and their tangible effects on ecosystems and communities in the United States and around the world. The policy landscape will be shaped by not only the impacts of changes in the climate, but also by the ways in which societies respond and by the emergence of new technologies for both altering the trajectory of emissions and adapting to new climate realities. Global climate records now show the fingerprints of warming in different phenomena around much of the world. The IPCC, in its most recent assessment report, documents warming trends over all land regions, even as natural variability adds substantial variance to local trends. And the highest temperature extremes have become more intense and frequent, almost everywhere, since the 1950s. Scientists are highly confident that these changes are attributable to human influence. But confidence in detecting trends and attributing them to human influence degrades across heavy precipitation events; drought trends are heterogeneous and not attributable to human activity with great confidence. For hurricanes, tornadoes, and other severe storms there is even less confidence in trends or their relationship to climate change. In general, a fair summary of the evidence is that for well-observed phenomena, like surface temperature or heavy rainfall, with a clear relationship to warming, our multidecadal observations are consistent with human influence overcoming natural variability over long time periods and extremes increasing. For regions that are sampled more sparsely, or phenomena with a higher noise-to-signal ratio, we will need to observe them longer to understand the magnitude of the climate signal or improve dynamical understanding using models and observations together. But for Climate For those who can’t wait, we also have new techniques that attempt to understand the role climate change has in influencing particular extreme events. When the climate is changing and disaster strikes, it is natural to ask whether that disaster was somehow “caused” by climate change. For scientists and policymakers acting in good faith, answering that question helps develop a more accurate picture of the problem, how it may be getting worse, and what preparations we should be making to respond to it. It may, at some point, give some weight to how liability is assigned by courts or adaptation funding is distributed by society. But how we ask this question is extremely important. It is easy to get the analysis wrong by discounting the role that meteorology plays. As meteorologist Theodore Shepherd explained in a clear 2016 review of climate attribution methods, “if a weather or climate event is truly extreme in the present climate, then perforce it requires unusual meteorological conditions, which means that climate change is at most a contributing factor.” Share Scientists have two ways to probe climate as a contributing factor, both of which have entered media coverage of extreme weather events. One asks a probabilistic question: How much more likely is a particular event (e.g., a temperature record over a particular area) amid global warming? The answer involves using historical records and computer simulations to estimate the likelihood of such an event in both a changed and a preindustrial climate. The findings are less about the specific event, and more about events of that nature. The other question is: How has the changed climate affected the specific event in question? Here, scientists try to understand what a similar event would have looked like in the preindustrial climate. This is sometimes called the storyline approach, where the story is the specific meteorological details of the event. These methods offer ways to test the intuition of scientists about real weather extremes. In late June and early July of 2021, a persistent high-pressure ridge, or heat dome, set up over the Pacific Northwest and an extraordinary heat wave affected the area from Oregon to British Columbia. For six days, it shattered temperature records across the region and hundreds died from heat-related causes, in an area where such high, and persistently high, temperatures were well outside of experience and many live without air conditioning. Scientists have studied its connection to climate change using multiple approaches. This specific event was created by a rare combination of meteorological factors, a strong high-pressure ridge created the conditions for extreme heat, which occurred on top of higher average temperatures in the region from global warming. Probabilistic analyses showed that climate change increased the likelihood of such an event by at least 8-fold to more than 100-fold. One standout example found that such an event had effectively zero probability of occurring in the preindustrial climate. The enormous range in these assessments reflects how hard it is to estimate probabilities of events at the tail of the historical record. Estimates of the effect on the temperature of the event are more clustered. A recent review paper documents how multiple methodologies have found a positive influence, roughly 1-2 degrees Celsius of an anomaly that exceeded 15 degrees, of climate change on the temperature magnitude of the event. Multiple studies have investigated and found some positive influence of climate change in other extreme events. Attribution studies found climate likely increased the heavy rainfall that accompanied Hurricane Helene in North Carolina and surrounding regions in 2024. The extensive fires that struck Los Angeles in 2025 illustrate how the causal chain can become messy, though. Studies do detect a positive influence of climate on the event’s likelihood, but while climate change likely contributed to underlying aridity, it would not have played a role in the heavy winds or land practices that preceded disaster. These event attribution studies will become more common for extreme, or damaging, weather events. They can be produced quickly, and often are reported before peer review. As the Pacific Northwest heatwave example shows, when multiple methods converge on a positive attribution, the finding should probably carry some weight even if you have to be careful about accepting the results from a single study. I expect that as climate change proceeds and the climate thus departs further from a preindustrial counterfactual, the influence will become more detectable across a variety of extreme events and more easily identified. This will be used to cast blame, but can also be used to inform how communities and society adapt to ongoing change. We May Still Be Surprised One positive development, insofar as less climate change is better, has been that our central estimates for future climate change should probably be revised downward. Mostly, that is because the high-end warmings that scientists regularly analyzed about ten to 20 years ago, driven by high emissions throughout the twenty-first century, now appear to be somewhere between unlikely and impossible. At one time, the upper end of mainstream climate projections extended well into 4 to 6 degrees Celsius of warming by the end of this century, which, models suggest, would have wrought enormous real-world damage. Current energy and policy trends now point toward 2.5 or 3 degrees. Damages and risks are commonly modeled as increasing steeply with more warming, so this is already a better-than-previously-expected outcome for the climate (which is independent of the physical response to emissions). But we should maintain a wide range for plausible outcomes and prepare for the possibility of being surprised. Emissions trajectories are subject to deep uncertainty, the physical climate response is still developing, and whatever change occurs in the climate will then be mediated through unpredictable economic, social, and political institutions. Over the past decade, the pace of warming surprised some keen observers and appeared to accelerate, though not yet outside the range of expectation provided by climate models. The reasons for that apparent acceleration are being actively studied (as was the apparent pause in warming from 1998 to 2012), but no single driver has emerged. Some blame it on the El Niño, variability which would have no bearing on climate. Some think it is a result of factories in East Asia and global shipping fleets cutting aerosol emissions, which in the strongest version of the argument would indicate higher climate sensitivity to carbon-dioxide emissions. Others are more measured, not yet ready to draw solid conclusions as to whether climate projections require revision. We will have to see. Long-Term Thinking Climate change asks us to think over long time scales. But the pace of human-driven warming is compressing a large global change into a century. Changing weather patterns and extreme events are already causing adjustment costs and damages and will do more. Adaptation will help, but it is not free. For some communities, these costs will erode livelihoods and well-being, and may force migration. Are we prepared for large-scale managed retreats in the United States? Thankfully, American wealth, geographical diversity, and moderate climates may leave us better prepared than many around the world. But wealthy countries can still suffer serious disruption from narrowly concentrated costs, even if they appear entirely manageable in aggregate. Readers of Commonplace are familiar with the challenges of rapidly adapting to economic forces. The displacement that came from the China Shock is barely perceptible in aggregate GDP and employment data, but it affected millions of people and those people were far less mobile than economic models tended to assume. Deindustrialization rippled through the nation with enormous effects for not only our economic vitality, but also our national security. The forces surrounding climate change may not be so different; the world gets richer and must accept some diffuse costs. Those may be modest overall, but cause all manner of unpredictable effects with which policymakers must cope. In the case of the China Shock, our faith in a growing pie served us poorly. We’ll need to do better on climate. Leave a comment
Troubled Addiction Treatment Provider Aware Recovery Care Acquired by Renew Health + Recovery
Renew Health + Recovery announced that it has acquired the troubled in-home addiction treatment provider Aware Recovery Care. However, the deal
On shores of Lake Ontario, the Toronto International Film Festival bristles at Trump's trade war
The 51st Toronto International Film Festival has unspooled against a backdrop of rising tensions between the U.S. and Canadian governments, though it would be hard to tell it from the convivial atmosphere on the ground | KMBZ
Your Entertainment Escape - Survivor 49 Contestant & Celebrating Batman Day
Fresno and Central Valley news, weather and sports
Women with same health conditions as men ‘less likely to be offered active treatment’
Men with heart, kidney or liver conditions more likely to be offered intervention compared with women, global analysis finds
Scientists Fuse Human Neurons Into the Brains of Mice
The studies may help reveal the causes of brain disease in people and point the way to treatments. But researchers already are calling for new ethical guidelines.
Anixa Biosciences Appoints UPenn's Dr. Carmen Guerra to Cancer Business Advisory Board
/PRNewswire/ -- Anixa Biosciences, Inc. ("Anixa" or the "Company") (NASDAQ: ANIX), a biotechnology company focused on the treatment and prevention of cancer,...
Anixa Biosciences Appoints UPenn's Dr. Carmen Guerra to Cancer Business Advisory Board
Anixa Biosciences, Inc. ("Anixa" or the "Company") (NASDAQ: ANIX), a biotechnology company focused on the treatment and prevention of cancer, today announced the appointment of Carmen Guerra, M.D., M.S.C.E., F.A.C.P., to its Cancer Business Advisory Board.
ClearNote Health to Showcase Power of 5hmC Signatures for Treatment Monitoring at AACR Conference on Pancreatic Cancer
SAN DIEGO, September 16, 2026--ClearNote Health will present new data for its Avantect® Pancreatic Cancer Test and its Virtuoso® platform at the AACR Conference on Pancreatic Cancer
Health Rounds: New dye for MRI exams detects lung cancer earlier
Hello Health Rounds readers! Today we highlight a potentially game-changing experimental contrast agent for MRI exams that may enable detection of lung cancer when tumors are small and more treatment options are available. We also report on a Johnson & Johnson antidepressant that appears to help improve sexual dysfunction in patients with major depressive disorder.
ESPN, Nick Saban turn 'College GameDay' into political propaganda
As Ted Cruz promoted the Protect College Sports Act on College GameDay, questions emerged about ESPN's role and motives.
Keystone Behavioral Health Releases Substance Use Treatment FAQ for York County Patients and Families
York County provider addresses frequently asked questions about medication-assisted treatment, detox, levels of care and the cost of treatmentRock Hill, SC, Sept. 15, 2026 (GLOBE NEWSWIRE) -- Keystone Behavioral Health, a York County provider of substance misuse prevention, intervention, treatment and recovery services, today released answers to frequently asked questions about substance use treatment for patients and families considering care. The FAQ addresses medication-assisted treatment, me
Penn State Health physician awarded grant to help fight pediatric cancer
HERSHEY, Pa. (WHTM) — A Penn State Health physician was awarded a grant in hopes of finding new treatments for pediatric cancer. Doctor Sinisa Dovat received a $400,000 Scholar Hope Grant fro…
Oregon's Dan Lanning Snaps at Reporter Regarding Dante Moore Question
Tensions flared following a narrow loss to Oklahoma State as the Ducks' head coach defended his quarterback's post-game absence, citing medical treatment and dehydration under intense questioning.
Former Discovery Behavioral CEO Launches New Addiction Treatment Venture
John Peloquin, the longtime CEO of Discovery Behavioral Health, has launched his own behavioral health venture. San Diego-based Integrated
Former Discovery Behavioral CEO Launches New Addiction Treatment Venture
John Peloquin, the longtime CEO of Discovery Behavioral Health, has launched his own behavioral health venture. San Diego-based Integrated
San Mateo County sheriff’s deputy denied mental health diversion in child abuse case
A judge said at least some of the deputy’s mental conditions were fits for the program, but no clinician had reported to the court that he would respond positively to treatment while in the program, leaving unfilled a key requirement…
Karma TMS Marks 20,000 TMS Treatments, Transforming Mental Health Care Across the Coachella Valley and Riverside County
Palm Springs, California--(Newsfile Corp. - September 15, 2026) - Karma TMS PC, a leading provider of Transcranial Magnetic Stimulation (TMS) therapy in Southern California, today announced it has delivered more than 20,000 TMS treatments to patients across the Coachella Valley and Riverside County. The milestone reflects nearly a decade of growth for the practice. It underscores the rising demand for effective, non-invasive, medication-free options for treatment-resistant depression, anxiety,..
Pluto’s Atmosphere May Be Starting to Collapse as a 150 Year Winter Takes Hold
Don’t worry, it’s supposed to do that.
Renew Health + Recovery Purchases Assets of Aware Recovery Care
Renew to operate in-home substance use disorder treatment across 11 statesMIDDLETOWN, CT / ACCESS Newswire / September 15, 2026 / Renew Health + Recovery today announced the completion of a transaction under which it purchased many of the assets of the in-home substance use disorder treatment provider, Aware Recovery Care. Renew will serve without interruption clients and families as it has acquired many of the clinical models and care teams.
Defending LGBTQI+ Health: Fostering Equitable Treatment
LGBTQI+ people lack access to safe, quality health care. States can take immediate steps to improve their health systems to better serve LGBTQI+ patients.
Yamaha Introduces The Compact B200A Soundbar With Dolby Atmos
This tiny soundbar has few frills for $250, but still supports Atmos audio.
Evvy raises $40M to expand precision medicine for vaginal health
Evvy, a precision medicine company focused on the vaginal microbiome, has raised an oversubscribed $40 million series B round. | Evvy makes an at-home vaginal health test whose results are clinician-reviewed and offers personalized treatment plans, also driving real-world data collection and research on women's health.
Scientists stunned as volcano cloud starts destroying methane
The Hunga Tonga eruption may have triggered a surprising chemical reaction that destroyed some of the methane released into the atmosphere. Scientists say the discovery could reshape estimates of methane pollution and inspire new methods for slowing near-term global warming.
Greening in China and India reshapes climate both locally and far away
A new study published in Advances in Atmospheric Sciences shows that greening in China generally cools the local climate with more rainfall over southern and northeastern China, while greening in India tends to produce warming and less rainfall. The Co-occurring greening in China and India yields uniform climate feedbacks across over half global lands, producing cooler and wetter southern China, cooler western Eurasia, and warmer northern North America.
Missouri should make medical respite part of its health care infrastructure
For a person experiencing homelessness, “discharge” can mean returning to a shelter, vehicle or street while managing a wound, infection or treatment.
Perez Hilton Moved to Residential Treatment Facility 1 Month After Mental Health Crisis
One month after suffering a mental health episode on TikTok Live, Perez Hilton is out of the hospital. “After weeks in the hospital receiving treatment for his physical injuries, Perez entered a resid...
DOL Mental Health Parity Bulletin 2026: MHPAEA Compliance Best Practices
On September 8, 2026, the DOL's Employee Benefits Security Administration issued Field Assistance Bulletin No. 2026-03 to clarify MHPAEA compliance and nonquantitative treatment limitations. DOL enforcement will focus on blanket treatment exclusions, medical necessity/prior authorization processes, and network adequacy. Read our alert for a practical compliance roadmap.
Middlesex Health Cancer Center receives $1M grant from Liberty Bank Foundation
Liberty Bank Foundation awarded $1M to Middlesex Health to support cancer screening, treatment technology and patient services.
Michael J. Fox: “The disease has become more difficult, but science shows that we are getting closer”
The actor, diagnosed with Parkinson's at age 29, became a leading figure in the search for treatments and a cure through the foundation that bears his name.
Researchers hope powerful new microscope will reveal ‘root cause’ of incurable bowel disease
No run-of-the-mill tech, ‘Curie’ operates at 10 times the resolution of conventional microscopy and could spur discoveries leading to new treatment
Scientists Resurrect 160-Million-Year-Old Molecules With Surprising Power Against Superbugs
Ancient mammalian antimicrobial peptides revealed stronger bacteria-killing activity in some cases, offering clues for designing future treatments against resistant infections. Some proteins that vanished millions of years ago may still have something to teach scientists about fighting modern infections. University of Oregon biologists have reconstructed antimicrobial molecules dating back as far as 160 million years,
Clapp, Williams to discuss featured exhibitions at TAG
TAG/The Artists Gallery’s September featured exhibitions pair Colleen Clapp’s atmospheric paintings with Joe Williams’ exploration of the artistic possibilities of figure photography.
America's Health Care System Is So Screwed That Patients Are Flying to China for Cancer Treatment
An experimental cancer treatment developed in the US has become a standalone industry in China, attracting throngs of medical tourists.
Mary Bird Perkins puts holistic health and survivorship at the center of cancer care
For many cancer patients, completing treatment can feel like crossing a finish line. But, even when the disease is in remission, the effects of treatment can affect a person’s daily
Alonso's approach looks unsustainable
There was a subdued atmosphere at the final whistle among Chelsea's players, staff and supporters. Chelsea had previously beaten Fulham 3-2, won 4-3 at home to Brighton and lost 2-1 at Arsenal. Having conceded twice here, Chelsea have now gone 20 Premier League matches without a clean sheet, a run stretching back to January.
Germany’s Political Tailspin: Your Weekly SPIEGEL Recap
It might be tempting to dismiss the results of last Sunday’s state election in Saxony-Anhalt, in which the far-right Alternative for Germany (AfD) party raked in 43.8 percent of the vote, as a rather unimportant extremist blip in a state that hardly anyone can find on the map. And you wouldn’t necessarily be wrong to do so. The state’s population – around 2.1 million – is a mere 2.5 percent of the German total. And while the state capital of Magdeburg was once the political heart of the Holy Roman Empire back when Otto the Great used to hang out there (more than a millenium … no … milennium … nope … millennium ago), it is today something of a backwater, albeit one with a ginormous cathedral in its center. We wanted to briefly interrupt this week’s newsletter to extend a heartfelt thank you to all of our subscribers, both new and old. And to remind you all that a free subscription gets you access to this newsletter every Saturday. A paid subscription, by contrast, gets you one DER SPIEGEL article every weekday, delivered to your inbox. We strive to select pieces that both demonstrate what Europe’s leading newsmagazine has to offer and provide an international audience – namely, you – with an insight into how Germany and Europe view the world. If you haven’t already signed up for a paid subscription, please consider doing so if you can. Our Substack channel relies entirely on reader support and we are excited to continue offering you the best of DER SPIEGEL. Subscribe But even beyond the fact that a huge percentage of the voters in the state decided to place an X next to a party with an ideological lineage that runs rather directly back to the right-wing extremist soup out of which the Nazi Party was born, the results are a perfect example of a phenomenon that has been plaguing German elections in recent years: the lack of an obvious path to a majority. Call it the Balkanization of German politics. There are a number of developments driving the phenomenon, but for the purposes of this newsletter, here are two of the most salient: Persistent voter frustration with the country’s two (former) big-tent parties – the Christian Democrats (CDU) on the center-right (17.2 percent in Saxony-Anhalt last Sunday) and the Social Democrats (SPD) on the center-left (9.3 percent). The presence of parties on the far left (Left Party), the populist left (the Sahra Wagenknecht Alliance – BSW) and the far right (AfD) with which mainstream parties are reluctant to form coalitions. So what happens now? Stories of the Week A Lack of Leadership The answer for many people in the country, and particularly within the CDU, is clear: pin (some of) the blame on Chancellor Friedrich Merz. According to a survey taken directly after the election in Saxony-Anhalt, 88 percent of respondents agreed with the statement that if the federal government in Berlin were doing a better job, the AfD wouldn’t be as strong. And it is true that the predominant impression of the federal government ever since Merz was sworn in on May 6, 2025, is one of ineffectiveness and bickering. His rather unique combination of bumbling-plus-bravado has also not exactly endeared him to the German public. Indeed, his standing in the country is so shaky that his popularity – according to recent polls – has now dropped even below the historic lows associated with his predecessor Olaf Scholz. The situation is such that the CDU even opted to keep him largely out of the campaign ahead of the Saxony-Anhalt vote. And since then, dissatisfied rumblings within the CDU have grown louder. DER SPIEGEL’s Swantje Karich notes that the problems with the CDU go much deeper than Merz. “The center-right has a trust problem. At a press appearance following the devastating election result in Saxony-Anhalt, Friedrich Merz said that the party wanted to ‘reach people more effectively’ through ‘emotional engagement.’ It sounded as though he were announcing a political program. On the basis of that statement, it is difficult to take his empathy seriously.” “The Chancellor’s chastened appearance did, at least, reveal where he stands: with his back to the wall. Elections will be held in Mecklenburg-Western Pomerania next week, and the CDU could fare even worse there. The party is polling at between 8 and 10 percent in the state.” “What is at stake is the political tradition that has lent stability to the Federal Republic since 1945: a democratic conservatism that understands what must be preserved, but also how to embrace progress and openness to the world. If the Union continues along its current path, it risks becoming politically irrelevant after the 2029 federal election – and Germany could soon find itself with a government of the far right.” The Trumpification of Political Debate? It is often said in Germany that to understand the political and social trends that will soon be dominant in Europe, one need only look across the Atlantic to the United States. When it comes to political debate, that has certainly proven true. Donald Trump understood early on that triggering mouth-foaming outrage among Democrats is an ideal way to both generate headlines and to secure loyalty among supporters. And he realized that far more quickly than the left side of the political spectrum understood that simply ignoring the old man might be the best recipe. To be sure, there have been signs recently that the US president may be over-relying on the strategy. Earlier this week, in an apparent grandpa-discovers-AI moment, Trump sent out 60 posts in the space of 10 hours, many of them AI-assisted images portraying him as a hero – or showing Iceland as part of the US (outrageous!!!). It was also during that slew of schlock that he explicitly backed the AfD with an “MGGA” post. In Germany, though, the outrage cycle remains in full swing, with much of the focus on those who would dare to vote for the AfD. They are alternately portrayed as being dim-witted, ungrateful, backward, racist or all of the above. That, argues DER SPIEGEL columnist Sabine Rennefanz, is not particularly helpful. “Everywhere on election night, people spoke of a watershed moment, a rupture, a turning point. But what is that supposed to mean in concrete terms? A watershed would imply an interruption, a moment of pause – perhaps even a willingness to rethink and learn. At first, there was little sign of that in the main television panels. Instead, the familiar rituals that had already shaped the election campaign continued: outrage, lecturing and abuse.” “That’s just the tone, one might object. They’re only talk shows. Given that the party’s state branch has been classified by domestic intelligence officials as confirmed right-wing extremist, there are more important problems than hurt feelings on television. Yet although the condescending tone is not the cause of the AfD’s success, it is an expression of the broader mood within the so-called political center – a kind of institutional blindness that too often treats material concerns as a communications problem.” “People have a pretty good sense of whether you like them – whether you approach them with curiosity or merely study, lecture and manage them as a problem group. They notice whether you genuinely want to understand their fears and pain, or whether you are simply waiting for the chance to correct them. They can also tell whether someone still has the energy to change things, or whether they have barricaded themselves behind platitudes and empty phrases.” “Anyone who wants an egalitarian democratic society cannot promise equality only to those whose language, tastes and moral convictions they share. They must also acknowledge the wounds, resentments and fears of those whose political conclusions they consider wrong. Acknowledging them does not mean agreeing with them. But a democracy that communicates with almost half its citizens only through warnings and labels gives up on political debate before it has even begun. An atmosphere must be created in which people can express their opinions without fearing that they will be canceled. We are currently a long way from that.” East-West? One of the clear undercurrents in the election last Sunday was, of course, Germany’s ongoing east-west divide, particularly as it pertains to the success of the AfD. Historically, the party has been far stronger in the former East German states than in former West German states. The fact that this generalization no longer reliably holds is certainly one of the primary concerns that many have about the party’s growth. And yet, there is still a distinct flavor of “stupid easterners, they don’t understand democracy” to the coverage. In the weeks before the vote, there was even a rather interesting back-and-forth in Germany’s culture pages about how ungrateful eastern Germans allegedly are for being pulled out of their pre-reunification backwardness and into the light of the West. DER SPIEGEL’s Jochen-Martin Gutsch has had enough. “Ten years ago, in 2016, elections were also held in Saxony-Anhalt. The AfD won more than 20 percent, which at the time rightly provoked outrage and incomprehension in western Germany. Today, in 2026, the AfD is also polling at around 20 percent in western German states, but this no longer provokes outrage and incomprehension. Instead, it is now regarded as proof of democratic conviction and civilizational resistance. After all, in the east, it’s 40 percent!” “This allows people to continue feeling morally superior to the East, but the wiser course would be to admit: if something doesn’t happen soon, the West will turn AfD-blue too. Or bluish.” “But will anything happen? The truly depressing thing about election night was not so much the AfD leaders intoxicated by their own success. It was the representatives of the other parties, who once again said that they were utterly shocked, needed some time to digest the result and would, of course, not simply return to business as usual. The SPD, a former big-tent party, celebrated its ‘stable’ result of 9.3 percent. Congratulations!” “For 10 years, the AfD has gone from one electoral success to the next. And still, the established parties remain ‘shocked’ and scratch their heads in astonishment. How long can they keep being shocked? Friedrich Merz says he may need to communicate his reform ideas in a more ‘emotional’ way. So the CDU’s political professionals sit down together after the election, mull over a strategy, and in the end come up with this: Fritz, try to be a little more relaxed, charismatic and emotional – or something. Beyond that: no political plan, no defiance, no promise of a future. That is frightening.” What was good, what was bad for democracy? Good: Voter turnout in Saxony-Anhalt was 77.8 percent, the highest ever recorded in the state. Whatever one thinks of the result, that figure is encouraging. Democracy needs citizens to take an interest. Bad: Although a strong AfD result had been expected in Saxony-Anhalt, many politicians from the mainstream parties – including in Berlin – appeared confused, helpless and overwhelmed in their initial reactions. That is not how they will win back voters’ trust. Last Week’s Highlights: 🗳️ Meet the Germans Who Voted for the AfD: Why would voters in a country like Germany, with its Nazi past, vote for a right-wing party? It’s a question only an editor in Berlin could come up with. On the ground, the view is different. 🟦 How the AfD Wants to Expand Its Power Across Germany: The far-right AfD is planning to decimate public broadcasting in Saxony-Anhalt, revamp education and install extremists in positions of power. And it is eyeing victory on the national stage as well. 🕯️ The Continuing Reverberations of September 11: It was a generational shock, and the consequences can still be felt today - from massive surveillance and significant increases in presidential power to violent excesses at ICE. 🤝 “For Europe, Canada Is the Preferred Partner in Trans-Atlantic Relations”: In an interview with DER SPIEGEL, Canadian Finance Minister François-Philippe Champagne discusses his country’s failed trade deal with the US and why Canada is looking to Europe. 🏛️ The True Historical Roots of the AfD: During the Weimar Republic in the 1920s, there were numerous parties on the extreme right espousing “Germany first” nationalism. The Nazis may not be the best comparison for today’s AfD. 🌊 AfD in a Landslide: Merz Is the Wrong Leader for Germany: The right-wing Alternative for Germany won in a landslide in Saxony-Anhalt state elections on Sunday. What does that mean for the country at large? Thank you for your continued support and have a wonderful week! Subscribe Share Leave a comment Your SPIEGEL Substack Team Compiled and edited by Charles Hawley
Meant Health Expands Telehealth Access to FDA-Approved GLP-1 Prescriptions, Including Ozempic®
Meant Health, a digital health platform that connects patients with licensed clinicians for evaluation, prescription and ongoing care coaching, announced today that it is expanding telehealth access to FDA-approved GLP-1 medications. The move is meant to shorten the distance between someone wondering whether a treatment might be right for them and an actual conversation with a U.S.-licensed clinician who could review their history and make that call.
Missouri should make medical respite part of its health care infrastructure
Missouri’s healthcare system routinely pays for a hospital stay, a surgery or a course of treatment, then reaches the edge of its own plan when the patient has no home in which to recover. For a person experiencing homelessness, “discharge” can mean returning to a shelter, vehicle or street while managing a wound, infection, cancer […]
Posts touting mebendazole as cancer treatment go beyond the science
The anti-parasitic drug mebendazole has shown preclinical efficacy in targeting multiple cancers, but experts say social media posts calling it a "cure" go too far. Additional clinical trials in humans are necessary to prove when, at what dosage, and in which treatment combinations it could make an impact.
Posts touting mebendazole as cancer treatment go beyond the science
The anti-parasitic drug mebendazole has shown preclinical efficacy in targeting multiple cancers, but experts say social media posts calling it a "cure" go too far. Additional clinical trials in human...
Carnival of Clubs helps Business Students find Connection and Community at UA Little Rock
University of Arkansas at Little Rock School of Business students recently had a chance to connect and find their place on campus through the Carnival of Clubs, which showcases various organizations and programs — all under a festive atmosphere. With music playing, and plenty of snacks and refreshments, the Sept. 3 event brought together students, ... Carnival of Clubs helps Business Students find Connection and Community at UA Little Rock
Wilmington health tech founder launches new venture
Several years after launching his health tech startup Artemis Immersive, founder Adam Isley is setting his sights on new horizons. Co-founded in 2023 by husband-and-wife Adam Isley and Kaylan Barbrey, along with Matthew Raffa and Bill Blakesley, Artemis Immersive began as a spatial medtech company that created digital renderings of medical scans for viewing in augmented reality (AR). Isley said the firm, which won an NC Tech award in the Biotech + HealthTech Innovation category last year, has raised $1.2 million in total in seed funding since launching. Isley has since created a new venture, Research and Me, building on the Artemis platform. Like Artemis Immersive’s core software, VoxScan, Research and Me combines health data with artificial intelligence in a 3D interactive environment to help patients better understand health outcomes and provide integrative wellness support. While the Artemis product is no longer Isley’s primary focus, he said the company’s technology and ambitions have evolved into different ventures, like Research and Me. "It's a different venture building on the Artemis platform, and there'll probably be more,” Isley said. He added, "I was very disappointed in the quality of the information available to general patients about their healthcare... I wanted to give patients more and a better plate of choices." Research and Me is still in its beta phase, Isley said, with usability testing ongoing in partnership with the firm’s partner, Medicap Pharmacy and Wellness Center, owned by Barbrey. "As someone who's kind of dedicated their life to working in healthcare, I've tried to bring this spirit and passion to it,” he said, “and a lot of the resources that we'll be providing are free — like a base level of free care for any patients, or medical education if they've got specific conditions." Isley describes Research and Me as a “patient-first” platform designed to securely store and pseudonymize health data and use AI and medical literature to generate insights. The insights are presented in an interactive 3D environment for patients and providers to explore conditions, treatments and wellness plans together. "It's almost like a democratization of understanding medical information," Isley said. "We take a whole bunch of clinical data, we take a whole bunch of peer‑reviewed, published studies on PubMed, and we try to turn them into chunks of information that normal humans can understand." Like VoxScan, the Research and Me platform lets users interact with 3D anatomical models for visualization. The platform provides a space for tracking, notes and insights. The platform also supports video conferencing, Isley said, allowing providers or coaches to examine models and data together. "We wanted to create a safe environment where you can start to learn and experiment with new features about your health, using agents to do that,” Isley said. While Research and Me is in beta-phase testing with Medicap Pharmacy, Isley said he envisions the platform serving a wellness-oriented community, working with sports performance clinics and hormone optimization. Isley, who is working towards a wellness-coach board certification, also plans to offer functional wellness consults through the platform. Long‑term, Isley says he wants the platform to embody an “integrative health practitioner” approach, “connecting experts of different fields and specializations in a way that they can make a greater impact in people's lives.” “For people in the state of North Carolina, it's already a win,” Isley said of the Medicap rollout, noting that partner clinics get “immediate resources for learning about their health and wellness conditions… out of the box.” Isley plans to launch Research and Me’s provider portal in 2028 and begin pursuing integrations with larger systems, he said.
Hottest In 125,000 Years? The Staggering Science Behind The Summer Heatwave
If you felt this summer was especially brutal, the data proves you were right. According to the National Oceanic and Atmospheric Administration (NOAA), the continental United States just endured its
Hottest In 125,000 Years? The Staggering Science Behind The Summer Heatwave
If you felt this summer was especially brutal, the data proves you were right. According to the National Oceanic and Atmospheric Administration (NOAA), the continental United States just endured its
Hottest In 125,000 Years? The Staggering Science Behind The Summer Heatwave
If you felt this summer was especially brutal, the data proves you were right. According to the National Oceanic and Atmospheric Administration (NOAA), the continental United States just endured its
Hottest In 125,000 Years? The Staggering Science Behind The Summer Heatwave
If you felt this summer was especially brutal, the data proves you were right. According to the National Oceanic and Atmospheric Administration (NOAA), the continental United States just endured its
Hottest In 125,000 Years? The Staggering Science Behind The Summer Heatwave
If you felt this summer was especially brutal, the data proves you were right. According to the National Oceanic and Atmospheric Administration (NOAA), the continental United States just endured its
Hottest In 125,000 Years? The Staggering Science Behind The Summer Heatwave
If you felt this summer was especially brutal, the data proves you were right. According to the National Oceanic and Atmospheric Administration (NOAA), the continental United States just endured its
“Dark Knight” actor makes rare comment on moment he learned costar Heath Ledger died
Gary Oldman reflected on Ledger’s 2008 death, after he and the Australian actor starred in Christopher Nolan’s acclaimed “The Dark Knight” Batman movie.
Health officials see a jump in human rabies exposures and mistakes in treatments, CDC says
Rabies is a viral disease that is practically always fatal but preventable when the proper treatment is given before the patient shows symptoms.
Health officials see a jump in human rabies exposures and mistakes in treatments, CDC says
Rabies is a viral disease that is practically always fatal but preventable when the proper treatment is given before the patient shows symptoms.
Health officials see a jump in human rabies exposures and mistakes in treatments, CDC says
Rabies is a viral disease that is practically always fatal but preventable when the proper treatment is given before the patient shows symptoms.
Health officials see a jump in human rabies exposures and mistakes in treatments, CDC says
Rabies is a viral disease that is practically always fatal but preventable when the proper treatment is given before the patient shows symptoms.
Hellberg eyeing home comforts against Norwich
Middlesbrough boss Kim Hellberg is relishing a Riverside return on Saturday and wants another special atmosphere.
Cancer Is Now The Leading Health Threat For 9/11 Survivors 25 Years On
By Ellyn Vohnoutka HealthDay ReporterFRIDAY, Sept. 11, 2026 (HealthDay News) — Twenty-five years after the World Trade Center attacks, cancer has become the defining health problem among survivors who breathed the toxic dust. The number who are getting help paying for cancer treatment has roughly ...
Federal Funding Increase Brings New Resources for Tribal Health and Diabetes Programs
Federal funding for Indian health increased for fiscal year 2026, including a significant boost for a program supporting diabetes prevention and treatment in Native communities. Congress provided approximately $5.86 billion for Indian Health Service services and facilities, a 1.3% increase over fiscal year 2025. The total includes approximately $5.05 billion for health services and $809.2 […]
Boycott launched against American Diabetes Association includes journal
Trump's $500 Obamacare promise, childhood cancer treatment with long-term risks, and more health news
Chimp convalescence, ant amputation: the wild world of animal doctors
When people are sick, we seek out medications and treatments to help heal. For a long time, scientists thought that was a uniquely human ability. But it turns out, many other animals do a version of it too! And since the late 1980s, western researchers have been trying to get a peek behind the curtain. And aside from just cataloguing all the cool examples just to know, there’s a real hope that studying animals’ medical cabinets may be the most promising way to expand our own. We get into the weeds with freelance science journalist Mandy Nguyen.Interested in more animal stories? Email us your ideas and questions to explore at shortwave@npr.org. They may become a future episode!Support public media with NPR+ and enjoy perks for over 25 podcasts like this one. This show’s perks include sponsor-free listening. Learn more at plus.npr.org.
Inside the Republican Midterm Convention, Where It Was ‘Trump-a-Palooza’
Amid the glitz, glamour and party atmosphere of an unusual midterm convention in Dallas, the president boasted of his accomplishments, predicted Republican victories and all but ignored the daunting political landscape his party faces this fall.
Airplane Turbulence May Worsen Thanks to Trump
Pilots depend on climate data from the National Center for Atmospheric Research to fly. The government wants to dismantle it.
Rensch: ‘Roma must be ready for Fenerbahce strong start’
Devyne Rensch warns Roma ‘must be ready’ for the atmosphere put on by Fenerbahce fans in tonight’s Champions League opener.It kicks off at the Sukru Saracoglu Stadium in Istanbul at 17.45 UK tim...
Lee Health convenient care centers offer shorter wait times for minor injuries
Lee Health's convenient care centers provide walk-in service and same-day treatment for minor injuries, offering an alternative to hospital visits.
September brings new name for PCOS
Polycystic ovary syndrome has been renamed polyendocrine metabolic ovarian syndrome to emphasize metabolic health and improve diagnosis and treatment.
Take Charge of Your Health Today: Safe and affordable housing
JENNIFER THOMPKINS Alzheimer’s disease and other forms of dementia can affect any family, but access to diagnosis, treatment and support is not equal across communities. For many African Americans, the path to care is complicated by limited access to health services, transportation, healthy food, reliable information, and trusted organizations. Those barriers, according to Jennifer Thompkins, president of […]
Luminis Health cyberattack delays cancer treatment and test results
The cybersecurity attack affecting Anne Arundel Medical Center and Luminis Health Care remains unsolved almost a week after it was first reported the hospital system was under a Code Black.
OPINION: A mental health crisis should end in treatment, not death
The death of Jayden Stephenson shows what can happen when Ohio's civil commitment process isn't used as intended.
Autism Decoded: New Science Is Opening Paths to Better Treatments
In the past few decades, researchers have identified hundreds of genes that increase the risk of autism spectrum
Independent Atmore trucker says higher diesel costs putting strain on business
PENSACOLA, Fla. -- Record-high diesel prices are putting a squeeze on independent truck drivers.
Does AFC Bournemouth’s Atmosphere "Problem" Raise a Bigger Question?
Despite the emphatic 4-0 win, Bournemouth’s underwhelming atmosphere against Lincoln was tangible, and as The Price of Football recently explored, the Cherries’ growing hospitality offering highlights a wider debate about matchday revenue, premium seating and what makes a stadium truly "valuable".
Luminis Health cyberattack delays cancer treatment and test results
The health system said it is still trying to determine which systems and how many patients are affected across its entire organization.
Scientists Made Ice Stay Solid Above 2,000°C. The 'Superionic Ice' Could Be Found Inside Uranus and Neptune
The researchers squeezed water to millions of atmospheres and discovered a bizarre new form of ice.
Healthy Living with USA Health: Enlarged Prostate Treatment Options
In this Healthy Living, we talk with Troy M. Sofinowski, M.D., an Endourologist at USA Health.
Veterans' mental health challenges
For many veterans, coming home does not mean leaving the impact of military service behind. As we approach the 25th anniversary of 9/11, it is important to recognize the mental health struggles many veterans face—often without treatment. Rawle Andrews jr., executive director of the American Psychiatric Association Foundation, discusses this with Good Day Austin.
Prisma Health to host free webinar on menopause
Prisma Health is offering a free webinar on Sept. 23 to help women better understand menopause, recognize common symptoms, and explore treatment options that can improve their quality of life.
Adidas' Handball Spezial Gets a Dynamic Polka Dot Collab
Sneaker Politics and Adidas have teamed up on a brilliant Handball Spezial featuring a patchwork polka dot treatment inspired by Buddy Guy. Find out how to buy the sneaker here.
Lava-Covered Planets Are Defying a Key Rule of Planetary Science
Researchers developed a model showing how lava-covered planets close to their stars can hold onto their atmospheres, which could help guide the search for life beyond our solar system. Some planets orbit so close to their stars that intense radiation should strip away their atmospheres. Yet several of these scorching, lava-covered worlds still retain thick
Labor Department Mental Health Insurance Guidance Seeks Balance
The Department of Labor released new guidance seeking to narrow enforcement related to gaps in how employers cover treatments for mental health and substance use disorders.
ECMO saves newborn with severe lung damage after RSV scare
At just 2 weeks old, Jocelyn Selle was flown to Sanford Children's Hospital in Sioux Falls -- the only home for ECMO treatment in the Dakotas.
Meet a Health Hero Finalist: Sharon Pervez-Khan
After her daughter Elora was diagnosed with an incurable, cancerous brain tumor, the Villanova mom made it her mission to accelerate research, funding, and life-saving treatment.
Scientists find a bone-building switch that could fight osteoporosis
An experimental compound called AP503 significantly strengthened bones in mice by activating GPR133, a receptor that boosts bone formation while slowing bone loss. Because the same treatment has also been linked to stronger muscles, researchers see intriguing potential for combating age-related decline and osteoporosis.
New Eugene facility will expand Oregon’s residential behavioral health system for youth
A 12-bed secure inpatient treatment facility in Eugene will serve youth ages 10-17 with acute behavioral health needs.
Epic v. Health Gorilla: “Working as Designed”
We’ve been on a bit of a legal bender since just before Labor Day, so let’s keep a good thing going! As predicted, Epic does not want its case against Health Gorilla consolidated with the data breach cases, so it filed a motion to vacate the conditional transfer. And because they had to explain to the Panel why this case is different, they put a good chunk of previously unseen Epic v. Health Gorilla discovery record on the public docket! Roll the tape! The Case Against Consolidation Before we get to the fun stuff, let’s do the housekeeping. Epic's motion boils down to three arguments (sorted in ascending order of how well they land): A judge has already decided this. Judge Olguin declined to relate the fraud action to another ELU case (Patterson v. UVA Health), holding that the two do not call for determination of substantially similar questions of law or fact. Epic asks the Panel to treat that (a Rule 42 ruling) as law of the case. The overlap is thin. The three common questions Health Gorilla and the Panel identified are neither numerous nor complex (the qualities the Panel looks for before centralizing). Moreover, they are outnumbered by the questions unique to each side: The breach cases turn on security architecture, notification timing, and patient-level access. The fraud action turns on false treatment attestations and breaches of the framework agreements. Consolidation costs more than it saves. 17 of 21 parties in the fraud action do not appear in a breach case. The cases are also at very different stages: Olguin has a scheduling order running through a January 2028 trial while the breach actions are much more nascent. I like the last two more than the first because they attack the basic economics of an MDL: there just may not be enough shared discovery here to justify dragging all the defendants and a relatively mature fraud case all the way to Florida. On the other hand (while I know exceedingly little about MDL and Rule 42), I have a hard time seeing why a district judge's decision about his own docket would control what the Panel does with the separate § 1407 question. I might be reading between the lines too much, but I sorta think Epic's own brief half-concedes this, framing the two provisions as "two sides of the same coin" but then adding "respectfully submit" (which is often lawyer speak for “we know this is a reach”). The Ladder Gets More Rungs Anyway, the arguments are not why you're here (aside from the lawyers, maybe). Back in June, we discussed how Epic was using the smaller defendants to build an evidentiary ladder toward Health Gorilla and Unit 387. Turns out discovery has been adding a few rungs of its own.
New outpatient clinic focused on suicide prevention opens in Burlington
University of Vermont Health held an open house last week to celebrate the opening of the Asha Clinic, which it describes as the only program in the region focused exclusively on suicide care. The clinic's work is led by Craig Bryan, an expert in suicide treatment and research.
Can AI fix health care? In the chaos of emergency rooms, the technology comes up short
CEOs of the biggest AI companies have predicted the technology will “eliminate most cancer” and “improve treatment of most other ailments.” But nowhere better illustrates the challenge facing AI than an emergency department.
Why does early treatment matter for psychotic episodes?
Early treatment for psychosis can improve recovery and challenge the idea that mental illness means a lifetime of suffering.
Anak Krakatau Rumbles Again
A powerful eruption from the Indonesian volcano lofted ash into the atmosphere, disrupting thousands of flights and degrading air quality.
Bernalillo County DA highlights need for accountability and reform in juvenile crime and behavioral health
Bernalillo County District Attorney Sam Bregman addressed crime, juvenile reform and behavioral health during a speech in Albuquerque, emphasizing the importance of accountability and treatment working together.
Scientists engineer ready-to-use cancer-fighting T cells for solid tumors
T-cell receptor, or TCR, therapy is a cancer treatment that genetically reprograms immune cells, called T cells, to hunt down cancer with precision. It's similar to another treatment, CAR T-cell therapy, ...
Joe Biden shares health update after prostate cancer diagnosis while issuing warning to others
Joe Biden revealed his radiation treatment from last fall "worked as intended" as he urged men to discuss prostate cancer screening with their doctors.
The Villages Health’s $541 million settlement highlights the cost of ‘upcoding’
The settlement describes how The Villages Health would go back into patients' medical files months later and add diagnoses -- sometimes adding in monitoring, evaluations or treatments.
Santa Cruz to build a new type of mental health care center for youth
Serenity Smith, who lived at a residential treatment facility in Santa Cruz in 2024, drives to work in Aptos on Monday, Aug. 31. (Amaya Edwards — Santa Cruz Local/CatchLight Local) Located at: 5300 Soquel Ave., Santa Cruz, CA 95062. Call (831)540-4141. Behavioral Health Resources
Parents of San Diego mosque gunman say a mental health facility failed to heed FBI warning
LOS ANGELES (AP) — The mother of Caleb Vazquez alleges in her lawsuit that Park Mental Health Treatment of San Diego failed to intervene despite signs that her 18-year-old son posed an imminent threat to himself and others.
Youth with CF on approved treatment still face mental health issues
Youth with cystic fibrosis continue to experience mental and behavioral health concerns despite treatment with Trikafta, according to a study.
Scientists Discover the 7 Stages a Meteoroid Goes Through Before Hitting Earth
An analysis of 75 meteorite falls identified seven distinct processes that occur as space rocks melt, break apart, and slow down before reaching the ground. A space rock entering Earth’s atmosphere does far more than simply “burn up.” By examining 75 meteorite falls recorded in videos and photographs, researchers identified seven distinct stages that shape
AZ's R&D chief Barr touts internal 'science success story' after IL-33 antibody's stellar showing in COPD
With a detailed data drop that AstraZeneca’s R&D chief described as an internal “science success story,” the British Big Pharma has secured an FDA priority review for what it believes could become a flagship biologic in chronic obstructive pulmonary disease (COPD). In detailed results from the late-stage Oberon and Titania trials—first teased in March and detailed in full at the European Respiratory Society Congress in Barcelona this week—the drugmaker laid out the extent of its IL-33 inhibitor’s potential to reduce moderate and severe exacerbations in a wide range of COPD patients still struggling with those “lung attacks,” as AstraZeneca’s Sharon Barr, Ph.D., called them, despite using standard-care inhaled therapy. In the headline results, a 300 mg dose of tozorakimab given once every four weeks curbed those moderate and severe exacerbations in the studies’ primary population of former smokers by 29% in the Oberon study and 34% in Titania. In the overall population of both current and former smokers, these reductions were 30% and 29%, respectively, versus placebo and inhaled standard of care. The benefits also extended to clinically meaningful exacerbation reductions in all prespecified patient subgroups and specifically turned up promising signals in patients across a range of blood eosinophil counts, with Barr telling Fierce that “it’s the details that make this even more exciting than the high-level results that we’ve already shared.” In fact, during AZ’s tozorakimab poster presentation at the ERS 2026 Congress this past weekend, attendees were so enamored by the data that event organizers had to encourage people to clear the room and look at the other presentations on offer, Barr said in an interview. “I think it really speaks to the fact that there is a lot of buzz around these data because the entire respiratory community has been so desperate for new therapies for these patients,” she explained. The respiratory disease continues to represent a “staggering unmet medical need,” Barr said, highlighting the COPD exacerbations that the Oberon and Titania studies homed in on, which she added carry a greater mortality risk than a heart attack. “When a patient has a severe exacerbation, only about half of them are still alive within three and a half years,” she pointed out. As for tozorakimab specifically, Barr christened the molecule “an AstraZeneca science success story,” harkening several years back to the point at which researchers began to explore IL-33 as a driver of respiratory disease, and COPD in particular. At the same time, “there was still so much that wasn’t understood,” she admitted, highlighting the insight that IL-33 signals through both ST2 and EGFR through the RAGE pathway, a discovery Barr attributed to AstraZeneca's own scientists. Understanding the need to tackle both pathways in COPD—and aware of competitor candidates in the hopper, including one that bound ST2—the company ultimately had to make some “courageous decisions,” Barr said. These included taking a prior COPD molecule offline and going back to the drawing board to reinvent its potential IL-33 label “to make sure that we had a molecule that could block signaling through both arms of the pathway, through both the reduced form and the oxidized form, knowing that we wouldn’t be first, but striving to be best.” “When we put [tozorakimab] into the clinic, we firmly believed that we had a differentiated molecule, and we saw the other molecules blocking just ST2 or partially blocking IL-33, unable to deliver two positive pivotal studies in COPD,” Barr explained. “We kept marching forward because we believed our molecule was differentiated, and now I think we have the clinical validation that supports that.” Ultimately, AstraZeneca finds itself on much better footing these days when it comes to potential biologic rivals to tozorakimab in COPD. Sanofi and Regeneron’s Dupixent, for instance, is approved to treat COPD exacerbations in patients with high eosinophil counts, but not low ones. Meanwhile, the future has become cloudier for other next-gen IL-33 candidates from Sanofi and Regeneron, as well as Roche, which have suffered trial flops in recent years. One other potential ingredient for AstraZeneca’s success in its duo of studies was that the company was “ambitious in the trial design, willing to look at an all-comers population,” Barr said, “and willing to enroll the most severe patients.” Prior studies for would-be biologics rivals in COPD “avoided enrolling” those patients, she pointed out. She also highlighted the Big Pharma’s painstaking design of exacerbations in its trial, which “gave us a very rigorous readout,” and pointed to “the extra effort and investment” the company put in to understand the effect of mucus plugs in patients. Barr described mucus production as a “key feature in disease diversity,” noting that mucus plugs—obstructing clumps of mucus that block patients’ airways—are associated with worse outcomes in COPD. In its data announcement, AstraZeneca noted that an integrated analysis of Oberon and Titania found tozorakimab “demonstrated a reduction in patients’ mucus plug score,” with the pharma claiming its biologic is the first to deliver such results in a broad COPD population. “So being able to reduce those mucus plugs, we expect, is an important part of driving benefit for patients who are living with COPD,” Barr said. Again touching on the breadth of the study populations, Barr added that tozorakimab “worked across all eosinophil levels in both current and former smokers across all levels of lung function,” which she suggested “really simplifies decision-making for clinicians, and it allows them to offer therapy to the broadest possible patient population.” In the highest patient eosinophil count group, tozorakimab helped chart a 43% reduction in exacerbation risk, which Barr stressed were “unprecedented data.” In the mid-level group, AZ’s drug delivered a 23% reduction and, in the lowest group, a 34% reduction in eosinophils, which Barr said suggests efficacy “in all patient subgroups.” As for AZ’s recent guidance upgrade on the medicine’s sales opportunity, the lift from a $3 billion to $5 billion range to $5 billion plus was informed by multiple factors, Barr said, including the fact that “in 2024, there were multiple competitors, and there aren’t anymore.” Additionally, “we know that this is a massive unmet medical need, and this is a really incredible set of data that we think will be very convincing to the clinical community,” Barr said. Looking ahead to a potential evolution of the COPD treatment landscape, Barr noted that most patients start treatment in the community with an option like a triple therapy, and for them, having an option like AstraZeneca’s inhaler Breztri will remain a “really important part” of that journey. But of the patients uncontrolled on triple therapy, which Barr described as “about half of them today,” just a “small fraction” are currently eligible for biologic therapy, which she emphasized AstraZeneca is working to change. Understanding that COPD is not a “one-size-fits-all” disease, AstraZeneca is also looking at its antibody drug Tezspire for patients with T2-driven disease, and the company continues to think about new mechanisms for tackling COPD through both systemic and inhaled drugs, Barr said.