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Apple event expected to deliver foldable iPhone and debut of new CEO John Ternus
Arsenal youngster in international tug-of-war
Ceadach O’Neill’s international future remains unresolved, with Northern Ireland and the Republic of Ireland both still possible options for the Arsenal youngster.Photo by Cameron Smith/Getty Imag...
Aspen School District renews membership with Valley Health Alliance
Valley Health Alliance announced today that the Aspen School District has renewed its membership, marking a significant milestone for both organizations.
MAC now says Big Ten replay officials erred in adding 1 second back for Michigan's Hail Mary, asks NCAA to recognize Western Michigan as the winner
Penn State Ranked No. 16 in Both Coaches, AP Polls
Penn State moved up in the week 1 version of the polls! They’re now No. 16 in the Coaches poll, as well as No. 16 in the AP. The absolute demolition of Marshall, maybe to a point not expected by the voters, allowed the Nittany Lions to start its ascent to a potential top 10 […]
Area high school girls flag football players join GN Sports to talk about event this weekend
“Full House” star Lori Loughlin files for divorce from Mossimo Giannulli after nearly 30 years of marriage
Loughlin and Giannulli both served prison time after pleading guilty in the college admissions scandal.
The U.S. bishops are speaking out forcefully on politics—and finally being heard
Prompted by the beginnings of both Leo XIV’s papacy and the second term of Donald J. Trump, the bishops are using their voice in a new way.
Scientists Are Still Trying To Understand How the Moon Formed
The Earth and the Moon have nearly identical isotopic compositions, and the Giant Impact Hypothesis strives to explain this. New research into the ancient impact shows how the temperature of both worlds, and how it affects the strength of the materials involved in the collision, shaped the outcome, including the isotopic compositions.
Ink Business Unlimited vs. Spark Cash Select: Which is best?
The Ink Business Unlimited and Spark Cash Select both earn 1.5% cash back with no annual fee. But the Ink Business Unlimited is better for most businesses.
Here's how parents can promote a healthy diet in kids without the unnecessary friction
Russia launches massive, deadly, and ‘complex’ attack against Ukraine
Fighting between Ukraine and Russia commenced after a 72-hour pause for diplomatic visits to both countries by U.S. officials. Russia launched a massive attack on Ukraine on Tuesday, firing dozens of cruise missiles and over 140 drones as the war raged on after this weekend’s peace talks brokered by U.S. envoys Jared Kushner and Steve […]
Are rich people really worse behaved? Here’s the science
Who’s more likely to steal sweets from a child? According to science, it’s the rich. A study seemingly confirming our suspicions about the moral behaviour of the wealthy was one of the winners of the 2026 Ig Nobel prizes, which honour research that makes you laugh and then think. Science editor Ian Sample tells Madeleine Finlay what the researchers think could be behind the phenomenon, and they explore some of the other awards, including one for a surprising quality we look for in our friends and another for a biomechanical definition of kissing
Dan Campbell Reveals Detroit Lions Guard Plan for Week 1
Dan Campbell is keeping Detroit's left guard competition alive entering Week 1. Christian Mahogany and Ben Bartch will split first-team practice reps, and both could see action against New Orleans.
Liverpool’s hunt for a new sporting director: Julian Ward and the standout internal options
FSG president Mike Gordon is leading the search for Richard Hughes' replacement, with both internal and external candidates being considered
Trinity Health plans to lay off 500 information technology-related roles
AMID POLITICAL AD BOMBARDMENT, SAUSAGE DECLARES ITS CANDIDACY… FOR DINNER
As political advertising floods screens, phones and mailboxes ahead of the 2026 midterm elections, Johnsonville is entering the race for Dinner 2026 with a candidate of its own: Sausage. Backed by new research commissioned by Johnsonville suggesting Americans are overwhelmed by both politics and meal planning, Sausage is running on a core promise to simplify dinner decisions.
AZ's R&D chief Barr touts internal 'science success story' after IL-33 antibody's stellar showing in COPD
With a detailed data drop that AstraZeneca’s R&D chief described as an internal “science success story,” the British Big Pharma has secured an FDA priority review for what it believes could become a flagship biologic in chronic obstructive pulmonary disease (COPD). In detailed results from the late-stage Oberon and Titania trials—first teased in March and detailed in full at the European Respiratory Society Congress in Barcelona this week—the drugmaker laid out the extent of its IL-33 inhibitor’s potential to reduce moderate and severe exacerbations in a wide range of COPD patients still struggling with those “lung attacks,” as AstraZeneca’s Sharon Barr, Ph.D., called them, despite using standard-care inhaled therapy. In the headline results, a 300 mg dose of tozorakimab given once every four weeks curbed those moderate and severe exacerbations in the studies’ primary population of former smokers by 29% in the Oberon study and 34% in Titania. In the overall population of both current and former smokers, these reductions were 30% and 29%, respectively, versus placebo and inhaled standard of care. The benefits also extended to clinically meaningful exacerbation reductions in all prespecified patient subgroups and specifically turned up promising signals in patients across a range of blood eosinophil counts, with Barr telling Fierce that “it’s the details that make this even more exciting than the high-level results that we’ve already shared.” In fact, during AZ’s tozorakimab poster presentation at the ERS 2026 Congress this past weekend, attendees were so enamored by the data that event organizers had to encourage people to clear the room and look at the other presentations on offer, Barr said in an interview. “I think it really speaks to the fact that there is a lot of buzz around these data because the entire respiratory community has been so desperate for new therapies for these patients,” she explained. The respiratory disease continues to represent a “staggering unmet medical need,” Barr said, highlighting the COPD exacerbations that the Oberon and Titania studies homed in on, which she added carry a greater mortality risk than a heart attack. “When a patient has a severe exacerbation, only about half of them are still alive within three and a half years,” she pointed out. As for tozorakimab specifically, Barr christened the molecule “an AstraZeneca science success story,” harkening several years back to the point at which researchers began to explore IL-33 as a driver of respiratory disease, and COPD in particular. At the same time, “there was still so much that wasn’t understood,” she admitted, highlighting the insight that IL-33 signals through both ST2 and EGFR through the RAGE pathway, a discovery Barr attributed to AstraZeneca's own scientists. Understanding the need to tackle both pathways in COPD—and aware of competitor candidates in the hopper, including one that bound ST2—the company ultimately had to make some “courageous decisions,” Barr said. These included taking a prior COPD molecule offline and going back to the drawing board to reinvent its potential IL-33 label “to make sure that we had a molecule that could block signaling through both arms of the pathway, through both the reduced form and the oxidized form, knowing that we wouldn’t be first, but striving to be best.” “When we put [tozorakimab] into the clinic, we firmly believed that we had a differentiated molecule, and we saw the other molecules blocking just ST2 or partially blocking IL-33, unable to deliver two positive pivotal studies in COPD,” Barr explained. “We kept marching forward because we believed our molecule was differentiated, and now I think we have the clinical validation that supports that.” Ultimately, AstraZeneca finds itself on much better footing these days when it comes to potential biologic rivals to tozorakimab in COPD. Sanofi and Regeneron’s Dupixent, for instance, is approved to treat COPD exacerbations in patients with high eosinophil counts, but not low ones. Meanwhile, the future has become cloudier for other next-gen IL-33 candidates from Sanofi and Regeneron, as well as Roche, which have suffered trial flops in recent years. One other potential ingredient for AstraZeneca’s success in its duo of studies was that the company was “ambitious in the trial design, willing to look at an all-comers population,” Barr said, “and willing to enroll the most severe patients.” Prior studies for would-be biologics rivals in COPD “avoided enrolling” those patients, she pointed out. She also highlighted the Big Pharma’s painstaking design of exacerbations in its trial, which “gave us a very rigorous readout,” and pointed to “the extra effort and investment” the company put in to understand the effect of mucus plugs in patients. Barr described mucus production as a “key feature in disease diversity,” noting that mucus plugs—obstructing clumps of mucus that block patients’ airways—are associated with worse outcomes in COPD. In its data announcement, AstraZeneca noted that an integrated analysis of Oberon and Titania found tozorakimab “demonstrated a reduction in patients’ mucus plug score,” with the pharma claiming its biologic is the first to deliver such results in a broad COPD population. “So being able to reduce those mucus plugs, we expect, is an important part of driving benefit for patients who are living with COPD,” Barr said. Again touching on the breadth of the study populations, Barr added that tozorakimab “worked across all eosinophil levels in both current and former smokers across all levels of lung function,” which she suggested “really simplifies decision-making for clinicians, and it allows them to offer therapy to the broadest possible patient population.” In the highest patient eosinophil count group, tozorakimab helped chart a 43% reduction in exacerbation risk, which Barr stressed were “unprecedented data.” In the mid-level group, AZ’s drug delivered a 23% reduction and, in the lowest group, a 34% reduction in eosinophils, which Barr said suggests efficacy “in all patient subgroups.” As for AZ’s recent guidance upgrade on the medicine’s sales opportunity, the lift from a $3 billion to $5 billion range to $5 billion plus was informed by multiple factors, Barr said, including the fact that “in 2024, there were multiple competitors, and there aren’t anymore.” Additionally, “we know that this is a massive unmet medical need, and this is a really incredible set of data that we think will be very convincing to the clinical community,” Barr said. Looking ahead to a potential evolution of the COPD treatment landscape, Barr noted that most patients start treatment in the community with an option like a triple therapy, and for them, having an option like AstraZeneca’s inhaler Breztri will remain a “really important part” of that journey. But of the patients uncontrolled on triple therapy, which Barr described as “about half of them today,” just a “small fraction” are currently eligible for biologic therapy, which she emphasized AstraZeneca is working to change. Understanding that COPD is not a “one-size-fits-all” disease, AstraZeneca is also looking at its antibody drug Tezspire for patients with T2-driven disease, and the company continues to think about new mechanisms for tackling COPD through both systemic and inhaled drugs, Barr said.
Florida State’s Third-Down Failures Prove Costly Against SMU
Florida State’s third-down failures proved costly against SMU, as execution issues on both sides helped turn opportunities into a 27-24 loss.
Wilbur O. and Ann Powers College of Business remains No. 1 in South Carolina, climbs nationally in Niche rankings
The Wilbur O. and Ann Powers College of Business begins the academic year with continued recognition at both the state and national levels.
Arsenal summer signing in contention for Napoli start
Bruno Guimaraes should be in contention to start for Arsenal against Napoli on Wednesday in the team’s Champions League opener, according to a report.Photo by Shaun Botterill/Getty ImagesArsenal hav...
New Apple Watch models launch this week, here’s what’s coming
Here’s what rumors say to expect from the new Apple Watch Ultra 4 and Apple Watch Series 12, both of which are being unveiled on Wednesday.
School students who use AI chatbots score lower in OECD science test
Students who use generative AI for specific tasks score lower in science than those who don’t, according to an OECD report.
Assessing Kelp Bed Expansion Around Kodiak Island in Alaska - NCCOS - National Centers for Coastal Ocean Science
Scientists from NOAA’s National Centers for Coastal Ocean Science Kasitsna Bay Laboratory joined a week-long mission to investigate the recent expansion of giant kelp forests in waters surrounding Kodiak Island, Alaska. Bull kelp, the predominant canopy kelp in the region, has been largely replaced by giant kelp in the last couple of decades. While both ... Read more
Has Tencent Music Entertainment Group (NYSE:TME) Fallen Below Fair Value?
Tencent Music Entertainment Group has seen its share price fall sharply over the past year, yet both an intrinsic value estimate based on a Discounted Cash Flow (DCF) approach and traditional earnings multiples currently point to the stock trading below those valuation checks. The disconnect between a weak recent share performance and signals of potential undervaluation is drawing attention to what the current price really implies about the business. Over the past 12 months the stock has...
'Guts, style and fight' - no need to panic yet
Coventry City are yet to get off the mark in this 2026-27 Premier League campaign, sitting bottom of the table with no points from the opening three games. BBC CWR fancaster Danny Finlay said Frank Lampard's side showed "guts, style and fight" at the Etihad which has convinced him they have enough to compete in the top-flight this season.
Dynamic Creatures Launches Interactive Character Robots for Hospitality & Entertainment
Dynamic Creatures, founded by ex-Boston Dynamics leaders, unveils a new category of mobile, interactive character robots for the hospitality and entertainment industries.
Dynamic Creatures Emerges from Stealth to Launch New Category of Mobile, Interactive Character Robots for Hospitality and Entertainment
Founded by former Boston Dynamics, Google, and Robotics and AI Institute leaders, company launches with an official Boston Dynamics partnership and major theme park engagementBOSTON, Sept. 08, 2026 (GLOBE NEWSWIRE) -- Dynamic Creatures, a robotics company designing and building interactive character robots for entertainment and hospitality brands, today emerged from stealth. The company is creating a new category of mobile characters that move naturally through guest environments, understand the
NFL preseason power rankings: Miami Dolphins start out near bottom
The Week 1 preseason NFL Power Poll from our Joe Schad is out. How low are the Miami Dolphins?
Tottenham's spending means they 'should be better'
BBC Radio 5 Live's Monday Night Club has been discussing Tottenham's start to the season, with Chris Sutton asking when boss Roberto de Zerbi is going to "take responsibility" for results against a background of the amount of money spent. Spurs are in the bottom three having picked up just one point from their opening three league games, and are yet to score a goal in the competition - though they did put five past Charlton Athletic in the Carabao Cup second round. "I've not seen those comments if he has done, but he's made a fair few excuses so far this season," said former Premier League striker Sutton.
15 years of our home! Celebrate on Juventus Play
Exactly 15 years ago, Juventus cut the ribbon on its new home. On 8 September 2011, thousands of people, both inside the stadium and watching on television, held their breath as they got their first g...
Democrats see rare signs of hope in solidly red Arkansas’ midterms
Democrats are trying to capitalize on President Donald Trump’s disapproval ratings while Libertarians pitch themselves to those frustrated by both major parties.
New Hampshire voters choose nominees for open Senate seat with Shaheen's retirement, and more races to watch today
Washington: Despite fueling AI’s wrong answers, data centers are uniting Dems and the GOP
Politicians from both sides of the aisle are raising strikingly similar concerns about water, energy and costs. The question is how long the unity will last.
Wycombe sack manager Michael Duff
Wycombe Wanderers have sacked manager Michael Duff just seven games into the 2026/27 season.The Chairboys are currently rock bottom of League One on just three points and are one of three teams withou...
Two well-known local political figures join the 2027 race for Knoxville mayor
The candidacies of Beau Hawk and Amelia Parker introduce an interesting dynamic to the race because both have emphasized progressive priorities.
Sununu, Pappas both face tests in quest for New Hampshire US Senate seat
NH Senate primary will see contested races on both sides, the outcomes of which could affect their party’s chances in the November general election.
Arm CEO says AI could cure cancer but data centers are a bottleneck
Getting there, however, will require enormous amounts of computing power, Haas said.
Eerily humanlike AI-powered robot enters mass production in China — its makers say it could soon be helping you out at home
Xpeng's engineers have designed a humanoid robot that they say is the first in the world that will walk itself off the production line.
Scientists sent a robot two miles below California and found a bigfin squid; it was the first live Northeast Pacific sighting
Two miles below the surface of the Pacific Ocean, off the coast of California, in a world of near total darkness and crushing pressure, a remotely operated vehicle glided silently through the water. Its cameras were scanning the deep for the strange and the seldom-seen when something extraordinary appeared on its screen.
Mod Revives Multi-GPU Gaming With Dedicated DLSS 5 GPU for Impressive FPS Gain
If you were around during what many consider the golden age of PC gaming, back when SLI was still possible, and, going back even further, when gamers put dedicated PhysX cards into their PCs, the latest trick shown off by modder, Marcelo Guibout, on YouTube. Guibot showed off a gaming setup using...
The science behind making the perfect banana
Bottas Wins Gun Runner For Second Straight Stakes Triumph
Miguel Clement-trained Vekoma colt drove between horses and collared pacesetter Conducted in the final sixteenth at Kentucky Downs to get the victory
Emporia State tabbed No. 22 in latest D2Football.com poll
EMPORIA (KSNT) — The Hornets are ranked for the first time this season. After defeating the then No. 11 Pittsburg State Gorillas 21-10 on Saturday, Emporia State football earned a No. 22 ranking from D2Football.com. The Hornets are 2-0 on the early season, after defeating Minot State 36-30 in their season opener. ESU secured both […]
Politics on parade: Candidates join Buena Vista Labor Day celebration
With the midterm elections fast approaching, the annual Labor Day Parade brought candidates for the U.S. Senate and the House of Representatives to Buena Vista on Monday.
Mental health services being offered at two schools
Riverside Counseling LLC will begin providing on‑site mental health services at both Eisenhower and Youngsville Schools starting in the 2026 school year. The initiative aims to make emotional and behavioral health support more accessible for students by offering therapy directly within the school buildings. “We are here to support the Youngsville and Eisenhower Schools by […]
Georgia Southern football prepares for Clemson in week two
STATESBORO, GA (WJBF)- Week two of the college football season features one local matchup in Georgia Southern and Clemson. Both teams coming into the game with something to prove. The Eagles are coming off a 31-0 victory over Charleston Southern, making it their first shutout win at home since 2023. They’ll now face a bigger […]