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Browns coach Todd Monken’s strong suit is blunt honesty without the politics
Monken's authenticity and commitment are strengths, said the Southern Miss AD who hired him for his only other head-coaching job in 2013.
Banijay Entertainment Dials Up Global Scripted with Premium Series Mania Slate
Media and entertainment powerhouse, Banijay Entertainment, today unveils its premium scripted offering for Series Mania, showcasing a broad range of high-end drama from across its global portfolio. As the number one European studio in scripted, with more than 100 titles launching each year, the company continues to demonstrate its scale, creative strength, global reach and […]
Today's hefty Crimson Desert patch includes "beginning of improvements" to keyboard and mouse controls, plus much more
Pearl Abyss has detailed a rather chunky patch for Crimson Desert, after its launch last week was marred by multiple issues and AI controversies.
Connections: Sports Edition today: Hints and answers for March 23, 2026, puzzle No. 546
Welcome to Connections: Sports Edition Coach — a spot to gather clues and discuss (and share) scores.
'Harry Potter' star details racist 'abuse' he suffered after joining upcoming TV show
Paapa Essiedu is speaking out about on 'abuse' he's endured since being cast as Severus Snape in the 'Harry Potter' TV series: 'Nobody should have to encounter this for doing their job.'
Carrie Anne Fleming, 'Supernatural' and 'iZombie' actress, dies at 51
Carrie Anne Fleming, who appeared on 3 episodes of 'Supernatural' as Bobby's wife Karen, has died. She was 51.
'Project Hail Mary' blasts off to record-breaking $80 million, becomes 2026's best premiere
'Project Hail Mary' burned through the outer layer of box office projections this weekend, reaching an astounding $80 million in its domestic premiere and $141 million worldwide.
Samsung Brings AirDrop Support to Quick Share with Galaxy S26 Series
Samsung is introducing AirDrop support to the Galaxy S26 series, making it easier for users to share content between devices using Quick Share. The feature will begin rolling out from March 231, starting in Korea and expanding to more regions including Europe, Hong Kong, Japan, Latin America, North America, Southeast Asia, and Taiwan. AirDrop support […]
Man Born with ‘Butterfly Syndrome’ Is Fighting for Change for ‘the Worst Disease You’ve Never Heard of’ (Exclusive)
Ohio resident Shane DiGiovanna, who has the rare disorder epidermolysis bullosa (EB), is advocating for legislation to help cover costly medical bandages for patients with the disease, which is also known as ‘butterfly syndrome.’
Former 'Bachelorette' star James Taylor re-arrested on assault charges in Texas
Former 'Bachelorette' star James Taylor has been re-arrested in Texas in connection to his 2024 assault case.
Khloé Kardashian Recalls How Her Divorce from Lamar Odom Made Her ‘Obsessed’ with Leading a Healthy Lifestyle
Khloé Kardashian opened up about her relationship with diet and exercise on the March 18 episode of her podcast, ‘Khloé in Wonder Land.’ She said she became ‘obsessed’ with exercise after examining how her food choices were affecting her quality of life.
Your Thymus and Your Healthspan
Our thymus gland plays a central role in the development or our immune system, specifically for supporting T cell development (how these cells got their name, maturation and differentiation in the thymus) and discriminating between self and foreign, non-self antigen proteins with production of dendritic cells. As we age, our thymus gland shrinks—the process known as involution—with progressive change from spongy to fatty tissue, with loss of functionality. But this process, with respect to timeline and extent, markedly varies from one person to the next. And to make things even more complicated, our thymus gland anatomy and precise location in the chest also is highly variable. So the famous Frank Netter diagrams from the 1960s (such as at left below) don’t capture the remarkable heterogeneity that a random set of 12 chest CT scans (below at right). What I consider as 2 landmark papers in Nature this week (here and here) used AI to quantify health of the thymus in 2 large cohorts, and then correlate the metric to a broad array of health outcomes. In this edition of Ground Truths, I’m going to cover three questions: (1) How was thymus health determined by AI?; (2) How is thymus health linked to key clinical outcomes? and (3) Are there ways we can promote a healthy (aka rejuvenate) thymus gland in our later years? Subscribe 1. How was thymus health determined by AI? This was accomplished by extensive work developing and validating an AI pipeline for 2 stages, the first for localization and segmentation of the thymus bed, and the second to quantify a digital marker, termed the thymic health score. There’s a lot to this algorithmic development, so I won’t go into all the details, but just provide a rudimentary outline of what was done. The 1st stage used supervised learning with 2 radiologists reviewing 2,461 chest CT scans. That work trained a 3D U-Net model to automatically identify the thymic bed’s 3D cropped region using center of mass coordinates, which reached 99.8% accuracy. The 2nd stage used a foundation model that was pre-trained with SwAV (which stands for Swapping Assignment between multiple Views), a self-supervised model, that generated a high-dimensional thymus representation of 4,096 features. That compares to the radiology reductionist and subjective scoring of 0 to 3 where 0 means the thymus is fully degenerated and fatty, and 3 is considered dense, intact glandular soft tissue. Notably, the self-supervised learning (SSL) performance was superior to supervised (AUC ~0.75 vs 0.55, respectively) reflecting the shallowness of the 0-3 classifier vs SSL’s holistic, self-taught AI. The thymic health score ranged from 0 to 100, with the highest number indexed to fully preserved thymic health. The algorithmic work extended to explainability with both Shapely value distribution, meaning the model was holistic not relying on any “magic” pixel, and occlusion sensitivity, demonstrating the model’s performance was not affected by ribs, sternum, lung tissue, but rather focused on the thymic bed directly. Below are a few saliency maps from the occlusion sensitivity that indicate the thymic bed focus, not affected by neighboring structures, using the jet color scale. Now the AI was ready for processing ~25,000 CT scans, each over 30 MB files, from the 2 large participant cohorts to provide a thymic health score, it did so in less than 14 hours, which is less than 2 seconds per scan! Share 2. How is thymus health linked to key clinical outcomes? The two cohorts were the National Lung Screening Trial, NLST (N=25,031) and the Framingham Heart Study, FHS (N=2,581) each with baseline demographics and long term follow up of >12 years for health outcomes. From the NSLT, you can see below that increased age and body-mass index were correlated to reduced thymic health. And, overall, men had reduced thymic health scores compared with women. There are a lot of graphs in the paper for outcomes, for both the NLST and FHS cohorts. To simplify the major outcomes, below is a composite Figure with striking reduction of all-cause mortality and for the different causes of death. The results were consistent between the 2 cohorts. For example, the cardiovascular mortality hazard ratio average was 0.57 in NLST and 0.38 in FHS (weighted to be 0.53 for the aggregate). The reduction of mortality also extended to digestive diseases and pulmonary disease (data not shown below). Lung cancer incidence was reduced by 36% for high vs low thymic health (Figure below, with a panel -incidence and b panel-mortality, adjusted for age, sex, BMI, smoking status). Notably, there was a smoker’s paradox: lower incidence and improved survival for lung cancer in smokers who had a high thymus health score. Smoking was associated with lower thymic scores whereas alcohol was not. Higher thymic health was linked to higher HDL cholesterol, lower triglycerides, lower fasting blood glucose, and lower systolic and diastolic blood pressure. Inflammation biomarkers, such as C-reactive protein and interleukin-6, were elevated in the people with lower thymic health scores. In their second paper, the same team looked at the relationship between thymic score and outcomes for 3,476 patients receiving cancer immunotherapy. The non-small cell lung cancer progression-free survival was reduced in patients with low thymic health score. A parallel relationship for survival was seen for other types of cancer including melanoma, breast, and kidney with a 44% lower risk among high thymic scores (Figure). A similar pattern was seen with different immune checkpoint inhibitors. The thymus health score outperformed programmed death ligand-1 (PD-L1)and tumor mutation burden (TMB) assay of the tumor and was an independent prognostic marker of progression-free survival. In this dataset, a direct connect with thymus score and adaptive immune function was noted with a correlation before cancer treatment for both T-cell diversity and thymus T-cell production (a metric known as T cell receptor excision circles). Thymus Removal Study There is a highly relevant citation about thymus function before moving onto ways to rejuvenate it. In 2023, a very important study of thymus removal during cardiothoracic surgery was published, with 1146 patients undergoing thymus removal vs 1146 matched controls (mean age 55 years). The adverse outcomes for thymus removal were striking, with a 2.9 higher risk of all-cause mortality and doubling of cancer incidence, 1.5 fold increase in cancer mortality, and 1.5-fold increase in autoimmune diseases. The immune function showed marked compromise after thymus removal, as reflected by CD4+ and CD8+ T cells (Figure below) Share Ground Truths 3. Are there ways we can promote a healthy (aka rejuvenate) thymus gland in our later years? In recent months we’ve learned a lot about the process of thymus involution and the pathways by which this may be modulated. Thymus involution is primarily due to loss to thymus epithelial cells (TECs) and there are 2 subtypes with different functions: the cortical, responsible for positive selection of T cells, and the medullary, for negative selection. When adipose tissue infiltrates the thymus, thymic adipocytes are pro-inflammatory, knocking out T-cell output. Likewise, systemic inflammation, or “inflammaging,” from smoking, obesity, and chronic stress promote thymic adipocytes. Now, from preclinical studies, we know about key pathways that account for these processes. Historically, back in 2014, FOXN1 was recognized as a single master transcription factor essential for TEC function, with studies in mice with forced FOXN1 upregulation leading to thymus regeneration. That laid the foundation for potential regrowth of quiescent thymus cells. It took awhile to find pathways to accomplish this goal and to even refute its role as the master regulator. The Liver-Thymus Axis Feng Zhang and his team recently showed that injection of an mRNA vaccine to the liver encoding DLL1, IL-7 and FLT3-L in combination, factors known to support thymopoiesis (Figure), successfully enhanced immune function in aged mice. However, the effect was transient. The FGF21 Story Two reports in 2025 addressed the thymus gland’s production of FGF21, a growth factor (fibroblast growth factor 21) and its control of thymus involution. This growth factor is also produced by the liver, but it doesn’t have impact on the thymus in aged rodent models. In contrast, The liver’s hepatocyte growth factor (HGF) has been shown to reverse senescent TEC structural changes. Growth hormone stimulates production of insulin growth factor-1 (IGF-1) in the liver and the thymus. Two small studies in human participants (TRIIM, for Thymus Regeneration, Immunorestoration, and Insulin Mitigation) of 6 and 50 people, respectively, treated with combined human growth hormone, metformin and DHEA, suggested the potential of slowing epigenetic aging and improving thymus mass and function. But the combination of drugs, small sample, and lack of controls make conclusions murky. Increased thymus FGF21 led to increased CD8 T cells in old mice and extended healthspan and improved physical performance. Building on the previous FOXN1 data, ablation of β-klotho, the obligatory co-receptor for FOXN1, accelerated thymic aging. The benefit to FGF21 was confirmed in a companion paper using an FGF21 knock-in mouse model showing thymus enlargement and increased TECs throughout the lifespan. (schematic Figure below). The accompanying editorial for these 2 papers speculated: “The proposed link between age-associated thymus involution and organismal aging is intriguing, and suggests we might seek to achieve systemic rejuvenation by counteracting thymic involution.” Other Factors Lessons from the Axolotl (Mexican Salamander) In an elegant set of experiments of the axolotl (Figure), known for its complete thymus regeneration after total surgical removal, mediators were identified. Surprisingly FOXN1 was dispensable. But midkine, a growth factor, appeared to be the driver, the initiator of thymus cell growth, survival, and repair. Other components that contributed were Postn+ (periostin-expressing mesenchymal niches) and Ccl19, a chemokine protein from the bloodstream. RANK and RANKL RANK (receptor activator of nuclear factor κB its ligand (RANKL) have been considered key regulators of medullary TECs. In a study of both aged mice and human thymus cell cultures, their key role was confirmed, with multiple benefits of resorting TEC function, recruitment of progenitor cells, and T cell development. Subscribe Summing Up This body of work strongly supports the health of the thymus gland as a critical regulator of human healthspan, not just a correlate or link. The new landmark studies are reinforced by the regenerative biology experimental models that have shown, via an array of mediators, that healthspan of aged mice is at least in part dependent on thymus gland function and its critical role for maintaining adaptive immunity. It sure seems that we’d be better off having an immune reservoir of naive T cells instead of a profile in older adults of exhausted, low quality, memory T cells, with a senescent phenotype. It is striking that we ignored the importance of the thymus gland for many decades. A wake-up call was the results of the thymectomy matched control study reviewed here, with the opposite of high thymic health score improved health outcomes. The convergence of AI and healthspan here is notable. The exceptional and laborious work for developing and validating (no less explaining) the AI to quantify thymus health set the foundation for probing the connect the major health outcomes in two cohorts with extensive follow-up. We’ve never had a way to meaningfully quantify the thymus gland before, so this represents important leverage of supervised, self-supervised, and transformer models. The study wouldn’t have been possible without AI. And it begs the question as to whether there are ways we can maintain our thymus at a high health score. But it’s not so simple to rejuvenate our thymus. There are multiple risks including the induction of autoimmunity, increasing the risk of cancer, and inducing a pro-inflammatory state. For example, factors that increase TEC proliferation could compromise the medulllary negative selection process and leak out auto-reactive (self-attacking) T cells. Thymic cells could be induced to proliferate, but we know, for example, that growth hormone and IGF-1 are associated with an increase risk of cancer. If thymus rejuvenation doesn’t clear out the accumulated senescent cells in older adults, then inflammation within the gland could block the production of TECs. Keeping these risks in mind, we now have identified many ways to keep our thymus healthy as we age that undoubtedly will be tested in clinical trials going forward. Ultimately, the benefit-to-risk tradeoffs will be defined. In the meantime, we have desperately needed an immunome. As I’ve stressed in multiple prior Ground Truths, we have no test in the clinic to assess a patient’s immune status! It was very encouraging for me to get an email from Hugo Aerts, the senior author of the landmark papers in the days after they were published: “I also wanted to say that your Substack on “Why We Need an Immunome” was inspiring for this work. We found it a very compelling perspective and greatly enjoyed reading it.” Just having an assessment of a person’s immune status via a chest CT scan, with millions of these performed per year, might help in guiding the right immunotherapy for cancer (e.g. more intensive, combinations for those with low thymic health scores) and help define people who are increased risk for age-related diseases of cancer, cardiovascular, and neurodegenerative. The main theme of Super Agers is that we now have many layers of data (genetics, proteins, biomarkers, organ clocks that can be integrated via multimodal AI) for us to define a person’s specific risk decades before one of these age-related diseases leads to symptoms, enabling prevention. From the new studies this week, we can add thymus health score as yet another way to understand a person’s risk, a window into their adaptive immune system and healthspan. And perhaps someday we will be able to safely rejuvenate the thymus, or maintain its health through one’s life, and use the thymus health score to monitor. NB: I wrote this post (No A.I.) A Quick Poll Loading... ********************************************************************* Thanks to Ground Truths subscribers (now > 200,000) from every US state and 212 countries. Your subscription to these free essays and podcasts makes my work in putting them together worthwhile. Please join! If you found this interesting PLEASE share it! Share Ground Truths Paid subscriptions are voluntary and all proceeds from them go to support Scripps Research. They do allow for posting comments and questions, which I do my best to respond to. Please don’t hesitate to post comments and give me feedback. Let me know topics that you would like to see covered. Leave a comment Many thanks to those who have contributed—they have greatly helped fund our summer internship programs for the past two years. It enabled us to accept and support 47 summer interns in 2025! We aim to accept even more of the several thousand who will apply for summer 2026.
Southern Living names top small towns, Florida snags 5 spots
St. Augustine named best small town in the Southern United States.
Chappell Roan reacts to claims her security made Jude Law's 11-year-old daughter cry: 'I do not hate children'
Chappell Roan has responded to claims that her security guard made Jude Law's 11-year-old daughter cry after she got excited when she spotted the singer in a hotel: 'I do not hate children— that is crazy.'
Crimson Desert admits it used generative AI for "early-stage iteration" and apologises AI images were not replaced before release
Crimson Desert developer Pearl Abyss has responded to claims its latest game used AI to generate images, admitting "2D …
Capcom celebrates Resident Evil's 30th anniversary by promising "even more wonderful experiences" are coming, but doesn't confirm when
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Apple iPhone Fold Might Have A Sun Glare Problem
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Drew Barrymore says talk show audience member once criticized her dating profile
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Ron DeSantis says politics should be more than 'sugar high' entertainment
'If it's not leaving something that is durable, then it doesn't matter.'
Ron DeSantis says politics should be more than 'sugar high' entertainment
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How investors use the BRRRR strategy to scale real estate portfolios
"My strategy is basically to use every property to fund the next one," said one real estate investor.
EA-US Politics Podcast: Mr Trump Goes to War
50-minute analysis of the chaos and destruction of Donald Trump and his inner circle as self-declared "President of Peace" wages war on Iran
Europe’s trade with Iran: Which countries do the most business with Tehran?
EU–Iran trade fell to its lowest level in two decades in 2025 due to sanctions. Trade continues on a limited scale, with Germany accounting for the largest share.View on euronews
The Business of Football: How many players do you need to win a World Cup anyway?
The English FA and the Premier League are having another row, as the club vs country debate rages on in English football
Connections: Sports Edition today: Hints and answers for March 22, 2026, puzzle No. 545
Welcome to Connections: Sports Edition Coach — a spot to gather clues and discuss (and share) scores.
Digimon Story: Time Stranger large-scale expansion DLC announced
Publisher Bandai Namco and developer Media.Vision have announced a large-scale expansion downloadable content for Digimon Story: Time Stranger. It will launch in 2027.
Barry Keoghan is 'hiding away' after online 'abuse' over his looks: 'You don't want to even be on screen anymore'
Barry Keoghan says online 'abuse' over his looks is 'becoming a problem' and has made him shy away from the public eye: 'You don't want to even be on screen anymore.'
'Eager to announce': Gurnee Mills mall announces multiple new stores, entertainment options opening
The owner of Gurnee Mills mall announced that multiple new stores and entertainment options, including IKEA, will be opening at the shopping mall over the next several months.
Surprise! Minecraft Dungeons 2 is coming later this year
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Here’s how Va. lawmakers suggest the next state budget handle federal health care funding fallout
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Not all business owners: How Business for Good is building a new voice in San Diego
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ChatGPT Took a Science Exam Designed by College Professors and Scored a Low D, and That Should Worry You
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'Peaky Blinders: The Immortal Man' writer says Tommy's ending was always the plan
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The insular bubble of caucuses and assemblies
Nearly 30 years ago, then-Federal Reserve Chairman Alan Greenspan coined the term “irrational exuberance” to describe the overheated stock market. That descriptive phrase could also apply to much of the political realm. The hype in politics often grossly exceeds the reality on the ground. In that vein, let’s focus on Colorado’s precinct caucuses held earlier […]
Woman, from Large Filipino Family That Loves Food, Thought Health Issues Were Caused by Her Diet. They Weren't (Exclusive)
A woman thought her health issues were caused by her diet, growing up in 'a big Filipino American family, where food is often the center of all gatherings.' However, Jamie Nangpi Harris' ailments were tied to Crohn's disease, a chronic, autoimmune-driven inflammatory bowel disease (IBD) that affects the digestive tract, she tells PEOPLE exclusively.
Vertical Farms Tried to Compete With Open Field Farming. It Isn’t Going Well.
The industry was a darling of the venture capital world 10 years ago. With many farms out of business, the remaining companies have scaled back.
Connections: Sports Edition today: Hints and answers for March 21, 2026, puzzle No. 544
Welcome to Connections: Sports Edition Coach — a spot to gather clues and discuss (and share) scores.
Press Release - Girls in STEM Program from Keystone Science School
Delivered in an all-girl+ learning environment, Keystone Science School’s Girls in STEM programs encourage participation, collaboration, leadership, and confidence.
What I’m seeing at Astros camp: Brice Matthews’ OF bid, Cam Smith’s mindset, more medical changes
Houston hired a new director of sports medicine and performance, and a new assistant athletic trainer.
Eviction reform, Aquarion, towing laws: CT politics news
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Group tied to Emily Gregory sends race-baiting text; Dems should condemn it
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Reparations Committee opens up applications for Black Business grant program
The city’s Reparation Committee, in collaboration with Oakton College, is launching a grant and training program to support Black entrepreneurs at
More Subnautica 2 legal trouble brewing amid claims Krafton "intentionally leaked" May release without consulting reinstated CEO
Lawyers for Subnautica 2 studio's newly reinstated CEO are reportedly pushing for Krafton to be found in contempt of court after it "leaked" a May release.
Oregon voters overwhelmingly approved limiting money in politics. Then politicians had their say.
Oregon’s Democratic-controlled Legislature approved a bill that supporters described as containing little more than technical fixes to what they’d written two years ago.
NVIDIA’s DLSS 5 Reveal Was a Mistake, Needs to Go Back to the Drawing Board, Says Eternal Darkness Dev Denis Dyack
Eternal Darkness creator Denis Dyack calls NVIDIA's DLSS 5 reveal a mistake and adds that it needs to go back to the drawing board.
Maternal and Infant Health in State Rural Health Transformation Proposals Set Promising Priorities in an Uncertain Landscape
Visit the post for more.
The Humanities: 5 Leadership Skills That Business Schools Don’t Teach
We were told to hire for efficiency. Optimization. Scale. And yet the five most important skills I look for in a leader rarely come from a business background at all.
Crimson Desert developers "doing our utmost" to respond to its various launch issues, as game still passes huge one-day sales milestone
Crimson Desert - the ambitious single player RPG spin-off from Pearl Abyss - has sold through 2m copies following its release.
Chadwick Boseman's widow shares details of his cancer journey and death: 'A betrayal of faith'
'Black Panther' star Chadwick Boseman died in August 2020 following a private battle with colon cancer. His widow is sharing new details of the actor's cancer journey and death.
Unknown Worlds co-founders' lawyers accuse Krafton of "intentionally leaking" Subnautica 2 release date
"Krafton self-servingly announced the launch without any regard to its impact on the game, the team, or the community," say lawyers
After weeks of hype, Crimson Desert debuts to high player counts but "Mixed" Steam reviews, citing "disjointed graphics", lovable cats, "awful" UI and more
Pearl Abyss' single player RPG spin-off Crimson Desert released last night, and has had a rocky debut.
Michigan confirms measles outbreak in Washtenaw County: What to know
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Christy Carlson Romano says 'Even Stevens' costar Shia LaBeouf 'doesn't deserve' Disney GOAT status
Christy Carlson Romano is firing shots at her old 'Even Stevens' costar Shia LaBeouf's direction, agreeing with Demi Lovato that LaBeouf 'doesn't deserve' to be counted among the all-time Disney Channel greats.
InSo brings fine dining, nightlife entertainment to Las Colinas
InSo is an upscale Southeast Asian fusion restaurant that turns into a lively nightspot.
"I genuinely thought my controller wasn't working" - Crimson Desert players are getting so annoyed with its clunky controls they're asking for launch day refunds
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Liverpool owner FSG shelves plans to create multi-club group
American firm had explored several possible deals to add to its portfolio of sports teams
How Pauline Hanson’s One Nation is changing politics: Full Story newsroom edition
Guardian Australia’s Josephine Tovey speaks with Mike Ticher and Sarah Martin about why the electorate is flocking to Pauline Hanson, One Nation and the rightwing political movement, and what major parties can do to win voters back
Senate Dems propose their own $200M ‘CT option’ health care bill
The Senate Dems’ “CT option” builds on Gov. Ned Lamont's actions and own proposal to create a state health care option, but goes further.
Super early 2027 Oscars predictions: Will Amy Adams finally win her first Academy Award?
Early 2027 Oscars contenders are already in the running for top awards. Here are EW's super early predictions for nominees, from Tom Cruise and Amy Adams to 'The Odyssey' and 'Dune: Part 3.'
Forget the Galaxy Watch 8, this upcoming Android smartwatch could be the new battery king
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Justin Bieber and Usher had "heated exchange" at Beyoncé, Jay-Z's Oscars after-party (Report)
The longtime friends and collaborators got into a "heated exchange" following the Academy Awards, TMZ reports.
New dispute emerges around Subnautica 2’s early access release
Lawyers for the ousted—and now partially reinstated—leadership team of Unknown Worlds, the studio behind Subnautica 2, are crying foul over news that the game will be released into early access in May. The release announcement earlier this week was made improperly, potentially “damaging the game and sowing additional confusion among the Subnautica community,” the lawyers said in a letter sent on Tuesday to Vice Chancellor Lori Will of Delaware’s Court of Chancery. In their letter, the lawyers also floated the idea of asking Will to find Krafton in contempt of the court’s ruling. The letter was sent just one day after Will’s bombshell ruling that publisher Krafton had breached its contract with Unknown Worlds’ executive team, when it fired them last June. The new issue isn’t necessarily the May early access timeframe, but how the news was announced. The letter and Krafton’s response have not been previously reported. A quick recap of prior events: Subnautica 2 is an unreleased, underwater survival adventure and the most-wishlisted game on Steam. Last year, longtime Unknown Worlds CEO Ted Gill, along with studio co-founders Charlie Cleveland and Max McGuire, were fired by Krafton. They swiftly sued, saying the publisher had terminated them to avoid paying out up to $250 million in potential performance-based bonuses. The studio leaders had hoped to earn that with an early access release of the game, which Krafton had blocked. The publisher argued in court that Subnautica 2 wasn’t ready, which the ousted execs disputed. On Monday, Will ruled that Krafton had violated its contract, firing the execs to avoid the performance payouts, and that it had to reinstate Gill and give him full authority over any early access release for Subnautica 2. On Tuesday, IGN reported on a new memo issued that day to Unknown Worlds staff by Steve Papoutsis, the executive Krafton had put in charge of Unknown Worlds after the 2025 firings. In the note, Papoutsis said that Subnautica 2 had passed a key development milestone “last week” and that he and Krafton had determined the game “is ready for Early Access release in May.” This news appeared to catch the lawyers for Gill, Cleveland and McGuire by surprise. On Tuesday night, they sent a letter to Will expressing “serious concerns” about whether it would be possible to forge an agreement with Krafton consistent with the judge’s order. Papoutsis’ memo was a problem, they wrote. He didn’t have the authority to declare anything about Subnautica 2’s release. As of 9am ET on Monday, March 16, the effective date of Will’s order, Papoutsis wasn’t CEO of Unknown Worlds. Gill was. And, per Will’s order, only Gill could make Subnautica 2 release decisions. They continued: Krafton self-servingly announced the launch without any regard to its impact on the game, the team, or the community—let alone this Court’s Opinion. Announcing the release of a game is momentous, and it is typically accompanied by significant marketing activity, fanfare, and community coordination. And most importantly, the announcement is carefully designed to maximize excitement for the game. That entire process was supposed to be driven by Mr. Gill. However, in defiance of the Court’s Opinion, Krafton has now taken that away, further damaging the game and sowing additional confusion among the Subnautica community. The lawyers speculated that Krafton had “intentionally leaked” Papoutsis’ memo and then issued an official statement to confirm the leak. Game File is a reader-supported publication. My reporting is only possible through support from readers like you. To support my work, consider becoming a free or paid subscriber. Subscribe On Wednesday, lawyers for Krafton defended their client in their own letter to vice chancellor Will, saying nothing they did violated her order nor showed contempt: Papoutsis’s message was simply celebrating the UW employees’ efforts toward a past event: Krafton’s pre-Opinion determination that Subnautica 2 was ready for Early Access release. There was nothing improper about conveying the results of the milestone review or thanking the development team for their dedication and talent. They added that Gill could still make his own call about Subnautica 2’s release: In his role as CEO, Gill will be able to assess independently his views on the state of Subnautica 2 and the appropriate release schedule; nothing in Papoutsis’s message alters Gill’s authority or discretion. Vice chancellor Will has not responded to the letters and doesn’t necessarily have to. Both parties were previously ordered by Will to confer this week and submit a proposed judgment consistent with her ruling. The letter from Gill’s attorney’s this week doesn’t indicate whether he would or would not support a May release for Subnautica 2. But it could limit his options. And, if Gill’s lawyers are right, the lack of marketing fanfare around the leak of the May date could dull the launch of the game. Any harm to Subnautica 2’s launch is an extra sensitive issue given the context of the legal dispute: millions of dollars of payouts are on the line, tethered to the scale of the game’s initial performance. In her ruling on Monday, Will noted that there was obvious “bad blood” between Gill’s side and Krafton but that the two would need to work together: “They can—and must—act in good faith to navigate their remaining contractual relationship.” Item 2: A new kind of couch co-op game A highlight of GDC each year is the Alt.Ctrl showcase that features games played with extremely experimental controllers. Perusing this year’s offerings last Friday, I found a game controlled with giant scissors, another with big toothbrushes and one that amounted to dumpster diving. My favorite was Pivot, a co-op game about collectively maneuvering a couch. It was developed by students at the University of Utah’s masters of arts and engineering games program. Players lift and tilt the physical couch in order to control the position of a virtual one. That virtual one is moving through an obstacle course on-screen, while being pursued by a giant skull. Developer Nishant Verma told me at GDC that the couch is made of styrofoam (this became more evident as I watched!) and that the name was a riff on an episode of the sitcom Friends. Item 3: In brief… 🚫 Ubisoft is laying off more than 100 workers at its Red Storm studio, as the North Carolina location known for decades for its Tom Clancy games, ceases in-house game development, VGC reports. 👀 On Monday, Nvidia’s revealed its DLSS 5 AI-driven graphics technology that purports to improve game graphics… and it has been roasted about it by the media and the online gaming public for the remainder of the week. The tech changed the faces of characters in footage from Resident Evil Requiem, Hogwarts Legacy and EA Sports FC, drawing accusations of giving carefully art-directed games the generic look of AI “slop.” Nvidia CEO Jensen Huang had said on Monday that “DLSS 5 is the GPT moment for graphics—blending handcrafted rendering with generative AI to deliver a dramatic leap in visual realism while preserving the control artists need for creative expression.” By mid-week, Huang was telling Tom’s Hardware that the new tech’s critics were “completely wrong” because game-makers could still “fine-tune the generative AI” to suit their game’s aesthetics.
ABC cancels Taylor Frankie Paul’s season of 'The Bachelorette' amid domestic violence investigation
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Looking for Answers Before Birth: How 2 UT Health Sciences Researchers Are Re-examining Childhood Obesity
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University of Montevallo’s Stephens College of Business Sales Team Earns Top Finish at National “Selling with the Bulls” Competition
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NBAA: Business Aviation’s Leadership in Sustainability Innovation Underscored in ‘CLIMBING. FAST.’ Capitol Hill Fly-In
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This Week in Sports Trivia: March 19, 2026
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This Google Maps update could change how you share your location
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Forum on harnessing Artificial Intelligence for health equity
Register to this forumOver the past decade, artificial intelligence (AI) has significantly evolved in complexity, performance, and utility. Its integration across a wide range of industrial sectors has accelerated, with healthcare emerging as one of the most transformative sectors. In this sector, AI has enabled high-impact applications – from enhancing the speed and accuracy of disease diagnosis and supporting clinical decision-making, to strengthening public health initiatives such as disease surveillance and workforce optimization. Moreover, AI holds immense potential to empower individuals, enabling them to take greater control of their personal health and well-being. Yet the central question remains: Who benefits, who is at risk, and do these innovations close or widen health inequities? While the potential of AI-enabled applications is substantial, many countries have approached their adoption with caution. This hesitancy stems from concerns about risks and benefits, including model bias, data breaches, privacy violations, and the erosion of professional skills due to over-reliance on AI. Additional barriers include inadequate data infrastructure and a lack of robust evidence on the most effective forms and interfaces of AI to enhance service delivery and system performance. Moreover, the rapid rise of Generative AI has introduced a heightened urgency for the development of comprehensive governance and ethical frameworks. The Asian Development Bank (ADB) Health Practice Team and Digital Sector, in collaboration with the World Health Organization (WHO) Regional Office for the Western Pacific, are convening the Forum on Harnessing AI for Health Equity on 25–26 March at ADB Headquarters. Senior health officials from 16 developing member countries (DMCs), alongside leading researchers, innovators, and policymakers from across Asia and the Pacific, will engage in discussions on how AI can be governed, financed, and scaled to deliver healthier lives for all. The forum is funded through the High-Level Technology Fund with support from the Government of Japan. Objectives The two-day forum aims to:Identify high-impact, evidence-based health AI use cases suitable for resource-constrained settings and map out a pipeline for potential supportIntroduce and validate the WHO's policy guidance on minimum necessary ecosystem for countries and institutions to self-assess readiness for AI adoptionObtain initial commitment from participating stakeholders to join a pilot regional initiative focused on data/model sharing for a priority health challengeEndorse a prioritized set of actionable policy recommendations focusing on governance, regulation, and sustainable financing necessary to scale high-impact health AI use cases in resource-constrained settings Target participants The forum will convene participants from 16 ADB DMCs including Bangladesh, Bhutan, Cambodia, Cook Islands, Fiji, Indonesia, Lao People's Democratic Republic, Mongolia, Nepal, Palau, Papua New Guinea, Philippines, Sri Lanka, Thailand, Uzbekistan, and Viet Nam. In addition, health system leaders and practitioners, private sector technologists, academic experts, representatives from civil society organizations, development partners, and philanthropic institutions engaged in AI for Health from Australia, the People’s Republic of China, Japan, Malaysia, New Zealand, Singapore, and the Republic of Korea will also be invited. SessionsDay 1 (25 March)Session 1: AI Use Cases for the Care Continuum: Improving Access and QualitySession 2: Adopting a risk-based approach for AI use case prioritizationSession 3: Establishing the Minimum Ecosystem for Implementation Risk ManagementSession 4: Future-Ready Health Workforce: Building Competency for Human-AI CollaborationDay 2 (26 March)Session 5: The Political Economy of AI in Health: Understanding Stakeholder Interests and their Impact on EquitySession 6: AI and Health Financing: Supporting Fair Coverage and ProtectionSession 7: AI Regulation and Oversight: Pathways for Different RealitiesSession 8: The Way Forward – Building Alliances and Regional Partnership How to registerThe forum will be held in a hybrid format. In-person attendance is by invitation only, while livestreaming of the forum will be available to the public. To register, please complete this form on or before 24 March 2026.Event organizers / partnersAsian Development Bank (ADB)WHO Regional Office for the Western Pacific High-Level Technology Fund (HLTF)ContactAkihito WatabeHealth Specialist, SD3-HSDawatabe@adb.org Jae Kyoun KimHealth Specialist, SD3-HSDjkkim@adb.org
Connections: Sports Edition today: Hints and answers for March 19, 2026, puzzle No. 542
Welcome to Connections: Sports Edition Coach — a spot to gather clues and discuss (and share) scores.
Zach Braff was mortified when Michael Fassbender mistook him for Dax Shepard in Vegas nightclub
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Michael Kay: 'I don't like wrapping sports in a flag and preaching patriotism'
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Ryan Gosling knows nothing in his career will ever matter because he was a 'liability' in 'Remember the Titans'
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New Cyberpunk TCG becomes the most-funded TCG game in Kickstarter history
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Should Congress Increase Taxes on Sports Betting?
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Youth Mental Health Action Lab: Leveraging First Spouses to Drive Change
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