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LIVE: Brazil vs France – FIFA World Cup 2026 warm up

Follow our live build-up, with full team news coverage, before our comprehensive text commentary stream.

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Mar 26 • 1:08 PM EDT • Sports • aljazeera.com
How to watch Diamondbacks vs. Dodgers

Opening Day has arrived! How to watch the Arizona Diamondbacks as they begin their 2026 season on the road against the Los Angeles Dodgers.

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Mar 26 • 12:03 PM EDT • Sports • arizonasports.com
Opinion: Business resilience requires smart connectivity

Enterprise leaders operate in an increasingly complex digital environment with the scale and sophistication of new threats looming large, making cyber resilience a prerequisite of doing business. | Understanding how connected technologies are evolving and what this means for security, performance and resilience is critical for businesses.

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Mar 26 • 11:00 AM EDT • Business • fiercewireless.com
CBS Sports offers split decision on Iowa vs. Nebraska Sweet 16

With tipoff coming later today, CBS Sports offered a split decision on who win between Iowa and Nebraska in the Sweet 16.

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Mar 26 • 9:30 AM EDT • Sports • hawkeyeswire.usatoday.com
Pokémon Champions' removal of IVs led to a "heated discussion" with one of the franchise's original devs

Settle it...with a Pokémon battle!

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Mar 26 • 8:00 AM EDT • Technology • gonintendo.com
Gilbert Latin restaurant, Chandler bowling alley cited by health inspectors

A popular Latin restaurant in Gilbert and other East Valley spots were cited by health inspectors in this week's Dirty Dining report.

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Mar 26 • 1:43 AM EDT • Health • azfamily.com
If Trump’s diplomacy fails, the Iran war could get much worse

Iran doesn’t seem to be susceptible to the art of the deal.

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Mar 26 • 12:00 AM EDT • Politics • cnn.com
13 Alert Traffic: Busy Houston sports weekend brings heavy traffic on I-10 Katy Freeway

As the heart of Houston transforms into a sports fan's dream, the additional traffic and weekend construction closures may make the experience of traveling to and from these events a bit of a nightmare.

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Mar 25 • 8:34 PM EDT • Sports • abc13.com
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Athletics vs. Detroit Tigers - Live Score

View the Athletics vs. Detroit Tigers game played on July 07, 2026. Box score, stats, play-by-play timeline, highlights, odds & more

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Mar 25 • 7:21 PM EDT • Sports • foxsports.com
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tvOS 26.4 Adds These New Features to Your Apple TV

Apple this week released tvOS 26.4, and the software update includes a handful of new features and changes for the Apple TV. tvOS 26.4 is compatible with all Apple TV 4K and Apple TV HD models released since 2015. To update your Apple TV, open the Settings app on the device, navigate to System → Software Updates, and select Update Software. Below, we have recapped what is new in tvOS 26.4.

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Mar 25 • 6:33 PM EDT • Technology • macrumors.com
West Suburban, Weiss hospitals suspending services due to billing problems: Resilience Health CEO

West Suburban and Weiss hospitals are suspending all patient care services due to what the CEO says are problems with the billing system.

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Mar 25 • 6:07 PM EDT • Health • abc7chicago.com
North Bay athletes of the week: Top performers in prep sports around region

Did you catch these standout performances?

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Mar 25 • 4:55 PM EDT • Sports • pressdemocrat.com
Casey O’Neill

Flyweight Contender Returns To Action For The First Time Since 2024 At UFC Fight Night: Adesanya vs Pyfer

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Mar 25 • 4:15 PM EDT • Business • ufc.com
High school students pitch business ideas during competition at Lincoln Financial Field

The group of students was selected from over 30 submissions.

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Mar 25 • 12:26 PM EDT • Business • 6abc.com
Franklin's Kendall Rumans leads Week 5 girls spring sports top performers

Franklin's Kendall Rumans recorded 7 RBIs to lead the list of Week 5 WNC high school spring sports girls top performers.

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Mar 25 • 12:12 PM EDT • Sports • citizen-times.com
Afeela EVs Really Are Vaporware. Sony, Honda Kill Entertainment-Focused Car

Sony's plans depended on technology from three upcoming Honda models. When Honda cancelled those EVs, Sony did 'not have a viable path forward' on Afeela.

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Mar 25 • 11:53 AM EDT • Entertainment • pcmag.com
USA TODAY Sports Network picks for Iowa State vs Tennessee in Sweet 16

USA TODAY Sports Network picks for Iowa State vs Tennessee in Sweet 16.

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Mar 25 • 6:30 AM EDT • Sports • desmoinesregister.com
Iowa State vs Tennessee prediction, analysis, Sweet 16 expert picks for men's March Madness

Our March Madness experts analyze the Sweet 16 matchup between No. 2 Iowa State vs No. 6 Tennessee in the 2026 NCAA Tournament on March 27.

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Mar 25 • 5:31 AM EDT • Sports • usatoday.com
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MLB power rankings: Dodgers vs. Everybody as Opening Day ushers in 2026

Dodgers' quest for World Series three-peat begins. Can anyone de-throne LA?

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Mar 25 • 5:31 AM EDT • Sports • usatoday.com
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Spring sports heat up Tuesday night in the Heartland

The Cape Central Girls Soccer team played its home opener against St. Vincent, while the Notre Dame Boys Baseball team hosted Portageville on Tuesday.

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Mar 25 • 12:01 AM EDT • Sports • kfvs12.com
Rising gas prices impact local businesses

As the nation continues to see rising fuel prices, businesses are feeling the impact.

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Mar 24 • 9:52 PM EDT • Business • abc30.com
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Memphis area spring sports top performers for Week 4 of the 2026 season

Here are Memphis area high school baseball, softball, boys soccer and lacrosse top performers from Week 4 of the 2026 season

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Mar 24 • 6:44 PM EDT • Sports • commercialappeal.com
Marvel Rivals Devs Won't Introduce Original Characters Anytime Soon, Because There Are Simply Too Many Marvel Characters Already

NetEase Games isn't worried about balance in Marvel Rivals as its roster expands with more playable heroes, but don't expect to see any original characters anytime soon.

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Mar 24 • 6:26 PM EDT • Technology • ign.com
Warriors' Moses Moody reportedly diagnosed with torn patellar tendon after being stretchered off vs. Mavs

Moses Moody went up for a breakaway dunk, but his left knee gave out in the final minute of overtime on Monday night.

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Mar 24 • 4:59 PM EDT • Sports • sports.yahoo.com
CVS Health and FTC Staff Agree to Proposed Insulin Settlement

The agreement would cover the company’s Caremark pharmacy benefit manager unit, which has denied wrongdoing.

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Mar 24 • 3:32 PM EDT • Health • barrons.com
Tone, Humor, and the Performative Aspect of Politics

Senators John Kennedy (R-LA) and Peter Welch (D-VT) joined C-SPAN "Ceasefire" host Dasha Burns to discuss the roles of tone and humor in politics.

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Mar 24 • 3:03 PM EDT • Politics • c-span.org
Women-owned shops in Montgomery County bring variety to local business scene

In honor of Women's History Month, the Valley Forge Visitors and Convention Board puts the spotlight on a few of the many women-owned businesses in the county. From a cheese monger in Skippack at the Grand Fromage to Ardmore shop Plant 4 Good and Cyrenity Sips Winery in Hatboro.

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Mar 24 • 12:50 PM EDT • Business • 6abc.com
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Preview: Two injured forwards return for Avalanche in Pittsburgh

The Avs look to get revenge against Pittsburgh tonight.

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Mar 24 • 12:35 PM EDT • Sports • sports.yahoo.com
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Samsung's cheaper Mini LED TVs are now on sale

Samsung unveiled new budget Mini LED TVs as well as some higher-end models using its Quantum Mini LED tech.

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Mar 24 • 11:00 AM EDT • Technology • engadget.com
Paranovus Entertainment Technology (PAVS) surges 125.9% as low-float dynamics amplify trading volatility

Paranovus Entertainment Technology Ltd. (PAVS) is up 125.9% today. Here is some analysis on what might have caused this price movement.Analysis: The most likely driver looks technical rather than fundamental: PAVS has been prone to sharp, liquidity-driven swings after its recent reverse split reduced share count and tightened the tradable float. This could also be because traders are positioning around potential changes in the company’s at-the-ma

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Mar 24 • 10:53 AM EDT • Entertainment • quiverquant.com
Ford recalls more than 254,000 SUVs due to software issues

Ford is recalling more than 254,000 SUVs in the U.S. after a software defect was found to impact rearview cameras and key driver-assistance safety systems.

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Mar 24 • 10:22 AM EDT • Business • foxbusiness.com
Seminoles’ McCray V and Steen Earn Academic All-District Honors as Named by College Sports Communicators

TALLAHASSEE – Florida State basketball standouts Robert McCray V and Alex Steen have been named Academic All-District honorees by the College Sports Communic...

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Mar 24 • 9:37 AM EDT • Sports • seminoles.com
MLB Opening Day 2026: How to watch every game, including Yankees vs. Giants, full four-day schedule, streaming info and more
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Mar 24 • 8:15 AM EDT • Sports • sports.yahoo.com
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1 in custody after police chase, crash after burglary alarm at sports bar in Elmwood Park

One suspect was injured and in custody after a police chase in Elmwood Park Tuesday morning, police said.

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Mar 24 • 7:45 AM EDT • Sports • abc7chicago.com
Parolin Named to College Sports Communicators Academic All-District Team - Boise State University Athletics

Dominic Parolin has been named to the College Sports Communicators Academic All-District Team, it was announced on Tuesday.

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Mar 24 • 6:05 AM EDT • Sports • broncosports.com
Magic face urgency to end skid vs. rising Cavaliers

James Harden and Donovan Mitchell took turns rescuing the Cavaliers on their three-game road trip, allowing Cleveland to sweep the Milwaukee Bucks, Chicago Bulls and New Orleans Pelicans.

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Mar 24 • 5:29 AM EDT • Sports • cbssports.com
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Giants do what they set out to vs. Sultanes

The tune-up game’s tune-up game.

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Mar 24 • 2:19 AM EDT • Sports • sports.yahoo.com
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An asteroid sample contains all the key components for life on Earth

DNA from a distance

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Mar 24 • 2:00 AM EDT • Science • theweek.com
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Cypress business owner charged with felony water pollution, authorities say

Detectives said the Cypress company, which power washes dump-truck engines, was dumping contaminated wastewater into a drainage ditch that eventually leads all the way to the Gulf.

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Mar 23 • 7:47 PM EDT • Business • abc13.com
Microsoft Aims to Supercharge Windows Performance and Cut RAM Waste in 2026

Perhaps this would help return some of the goodwill it lost in 2025.

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Mar 23 • 5:38 PM EDT • Technology • pcmag.com
MacBook Neo Silences Critics Over 8GB RAM Being Inadequate; Can Open 60 Apps In Unison While Windows Laptop Powers Off Performing The Same Task

A YouTube channel decided to take the MacBook Neo for an apps stress test and opened up 60 apps at the same time to see if that 8GB RAM will be sufficient

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Mar 23 • 5:31 PM EDT • Technology • wccftech.com
Long fingernails vs. touchscreens: This nail polish could help

Undergraduate's prototype conductive nail polish could turn long fingernails into touchscreen styluses.

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Mar 23 • 1:48 PM EDT • Technology • arstechnica.com
Expanded NICU offers families privacy, innovation

The NICU at Temple Health's new Women and Families Hospital offers twice the space and many more services than its predecessor.

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Mar 23 • 1:39 PM EDT • Health • 6abc.com
Lenoir-Rhyne Sports Hall of Fame Nominations Due April 1

HICKORY, N.C. - Nominations for the Lenoir-Rhyne Sports Hall of Fame are due by Wednesday, April 1. The 2026 Hall of Fame ceremony will take place on Saturday, September 19, prior to Lenoir-Rhyne's 6:00 p.m. football game vs. Mars Hill.

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Mar 23 • 8:14 AM EDT • Sports • lrbears.com
Spurs vs. Heat odds, prediction, time: 2026 NBA picks for Monday, March 23 from proven model

SportsLine's proven model has revealed its San Antonio Spurs vs. Miami Heat predictions and NBA picks today

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Mar 23 • 6:01 AM EDT • Sports • cbssports.com
The 'Nail Test': Why This $54 Billion Innovation Is Terrifying Western Auto Executives

BYD says it's fixed yet another major problem with EVs.

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Mar 23 • 6:00 AM EDT • Technology • inc.com
Ohio State vs Notre Dame predictions, picks, odds for NCAA Tournament Second Round

Our March Madness experts pick the winner for No. 3 Ohio State vs No. 6 Notre Dame in the 2026 women's NCAA Tournament on March 23

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Mar 23 • 5:08 AM EDT • Sports • usatoday.com
UConn vs Syracuse predictions, picks, odds for NCAA Tournament Second Round

Our March Madness experts pick the winner for No. 1 UConn vs No. 9 Syracuse in the 2026 women's NCAA Tournament on March 23

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Mar 23 • 5:08 AM EDT • Sports • usatoday.com
Where to watch South Carolina vs. USC in March Madness Second Round: Time, TV Channel

The No. 1 South Carolina Gamecocks face the 9 USC Trojans in the Second Round of the women's NCAA Tournament. Here's how to see all the action.

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Mar 23 • 5:08 AM EDT • Sports • usatoday.com
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I tested ChatGPT vs. Perplexity with the same 5 prompts — the winner surprised me

AI Madness Round 1: The Heavyweight meets the Challenger in our first round of Tom's Guide AI Madness

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Mar 23 • 2:00 AM EDT • Technology • tomsguide.com
Yankees set to leave Florida in good health one year after spring from hell with one question looming

And just like that, Camp Snooze is over — at least the Florida portion.

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Mar 22 • 11:50 PM EDT • Health • nypost.com
A DNA test ruled him out. He was convicted of murder anyway.

Forensics has its share of high-profile problems. There’s phony “junk science,” like bogus bite-mark and blood spatter analyses that have sent innocent people to jail. And there’s the steady drumbeat of lab scandals, where analysts make up results. But there’s a subtler and more pervasive problem at work in many cases: lab analysts and lawyers who take perfectly legitimate science and twist it. Globe Opinion is exploring these distortions with a series we’re calling “Twisted Science.” And there may be no better place to start than with the case of Terrel Barros.

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Mar 22 • 9:57 PM EDT • Science • bostonglobe.com
Alabama vs. Texas Tech odds, time, March Madness predictions: 2026 NCAA Tournament picks from proven model

SportsLine's model has revealed its Texas Tech vs. Alabama picks for the NCAA Tournament 2026 second-round game on Sunday

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Mar 22 • 8:03 PM EDT • Sports • cbssports.com
Arizona vs Utah State live updates: Prediction, how to watch March Madness Round 2 game

Folks were gushing about Jerrod Calhoun and Utah State's offense in Round 1. Arizona is a whole different obstacle. Follow March Madness Round 2 game.

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Mar 22 • 4:05 PM EDT • Sports • usatoday.com
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CBS analyst picked against Purdue basketball. Here's what he thinks of Sweet 16 vs Texas

Boilermakers fans were critical of Seth Davis for his pick proven wrong after Purdue beat Miami. Here's what he thinks of the Sweet 16 game vs Texas.

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Mar 22 • 3:15 PM EDT • Sports • indystar.com
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Welcome to allergy season. Here's how to protect yourself

Where you live, what you're allergic to and your lifestyle can make a big difference when it comes to the severity of your allergies.

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Mar 22 • 2:47 PM EDT • Health • abc7ny.com
Florida vs Iowa live updates: Prediction, how to watch March Madness Round 2 game

Defending national champion Florida didn't need a warm-up to get going in their NCAA title defense. Will Iowa provide any resistance in March Madness?

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Mar 22 • 2:23 PM EDT • Sports • usatoday.com
'Disgusting.' Democratic senator slams Trump's reaction to Mueller's death

Sen. Chris Murphy called President Donald Trump's response to the death of Robert Mueller "disgusting."

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Mar 22 • 2:20 PM EDT • Politics • usatoday.com
Your Thymus and Your Healthspan

Our thymus gland plays a central role in the development or our immune system, specifically for supporting T cell development (how these cells got their name, maturation and differentiation in the thymus) and discriminating between self and foreign, non-self antigen proteins with production of dendritic cells. As we age, our thymus gland shrinks—the process known as involution—with progressive change from spongy to fatty tissue, with loss of functionality. But this process, with respect to timeline and extent, markedly varies from one person to the next. And to make things even more complicated, our thymus gland anatomy and precise location in the chest also is highly variable. So the famous Frank Netter diagrams from the 1960s (such as at left below) don’t capture the remarkable heterogeneity that a random set of 12 chest CT scans (below at right). What I consider as 2 landmark papers in Nature this week (here and here) used AI to quantify health of the thymus in 2 large cohorts, and then correlate the metric to a broad array of health outcomes. In this edition of Ground Truths, I’m going to cover three questions: (1) How was thymus health determined by AI?; (2) How is thymus health linked to key clinical outcomes? and (3) Are there ways we can promote a healthy (aka rejuvenate) thymus gland in our later years? Subscribe 1. How was thymus health determined by AI? This was accomplished by extensive work developing and validating an AI pipeline for 2 stages, the first for localization and segmentation of the thymus bed, and the second to quantify a digital marker, termed the thymic health score. There’s a lot to this algorithmic development, so I won’t go into all the details, but just provide a rudimentary outline of what was done. The 1st stage used supervised learning with 2 radiologists reviewing 2,461 chest CT scans. That work trained a 3D U-Net model to automatically identify the thymic bed’s 3D cropped region using center of mass coordinates, which reached 99.8% accuracy. The 2nd stage used a foundation model that was pre-trained with SwAV (which stands for Swapping Assignment between multiple Views), a self-supervised model, that generated a high-dimensional thymus representation of 4,096 features. That compares to the radiology reductionist and subjective scoring of 0 to 3 where 0 means the thymus is fully degenerated and fatty, and 3 is considered dense, intact glandular soft tissue. Notably, the self-supervised learning (SSL) performance was superior to supervised (AUC ~0.75 vs 0.55, respectively) reflecting the shallowness of the 0-3 classifier vs SSL’s holistic, self-taught AI. The thymic health score ranged from 0 to 100, with the highest number indexed to fully preserved thymic health. The algorithmic work extended to explainability with both Shapely value distribution, meaning the model was holistic not relying on any “magic” pixel, and occlusion sensitivity, demonstrating the model’s performance was not affected by ribs, sternum, lung tissue, but rather focused on the thymic bed directly. Below are a few saliency maps from the occlusion sensitivity that indicate the thymic bed focus, not affected by neighboring structures, using the jet color scale. Now the AI was ready for processing ~25,000 CT scans, each over 30 MB files, from the 2 large participant cohorts to provide a thymic health score, it did so in less than 14 hours, which is less than 2 seconds per scan! Share 2. How is thymus health linked to key clinical outcomes? The two cohorts were the National Lung Screening Trial, NLST (N=25,031) and the Framingham Heart Study, FHS (N=2,581) each with baseline demographics and long term follow up of >12 years for health outcomes. From the NSLT, you can see below that increased age and body-mass index were correlated to reduced thymic health. And, overall, men had reduced thymic health scores compared with women. There are a lot of graphs in the paper for outcomes, for both the NLST and FHS cohorts. To simplify the major outcomes, below is a composite Figure with striking reduction of all-cause mortality and for the different causes of death. The results were consistent between the 2 cohorts. For example, the cardiovascular mortality hazard ratio average was 0.57 in NLST and 0.38 in FHS (weighted to be 0.53 for the aggregate). The reduction of mortality also extended to digestive diseases and pulmonary disease (data not shown below). Lung cancer incidence was reduced by 36% for high vs low thymic health (Figure below, with a panel -incidence and b panel-mortality, adjusted for age, sex, BMI, smoking status). Notably, there was a smoker’s paradox: lower incidence and improved survival for lung cancer in smokers who had a high thymus health score. Smoking was associated with lower thymic scores whereas alcohol was not. Higher thymic health was linked to higher HDL cholesterol, lower triglycerides, lower fasting blood glucose, and lower systolic and diastolic blood pressure. Inflammation biomarkers, such as C-reactive protein and interleukin-6, were elevated in the people with lower thymic health scores. In their second paper, the same team looked at the relationship between thymic score and outcomes for 3,476 patients receiving cancer immunotherapy. The non-small cell lung cancer progression-free survival was reduced in patients with low thymic health score. A parallel relationship for survival was seen for other types of cancer including melanoma, breast, and kidney with a 44% lower risk among high thymic scores (Figure). A similar pattern was seen with different immune checkpoint inhibitors. The thymus health score outperformed programmed death ligand-1 (PD-L1)and tumor mutation burden (TMB) assay of the tumor and was an independent prognostic marker of progression-free survival. In this dataset, a direct connect with thymus score and adaptive immune function was noted with a correlation before cancer treatment for both T-cell diversity and thymus T-cell production (a metric known as T cell receptor excision circles). Thymus Removal Study There is a highly relevant citation about thymus function before moving onto ways to rejuvenate it. In 2023, a very important study of thymus removal during cardiothoracic surgery was published, with 1146 patients undergoing thymus removal vs 1146 matched controls (mean age 55 years). The adverse outcomes for thymus removal were striking, with a 2.9 higher risk of all-cause mortality and doubling of cancer incidence, 1.5 fold increase in cancer mortality, and 1.5-fold increase in autoimmune diseases. The immune function showed marked compromise after thymus removal, as reflected by CD4+ and CD8+ T cells (Figure below) Share Ground Truths 3. Are there ways we can promote a healthy (aka rejuvenate) thymus gland in our later years? In recent months we’ve learned a lot about the process of thymus involution and the pathways by which this may be modulated. Thymus involution is primarily due to loss to thymus epithelial cells (TECs) and there are 2 subtypes with different functions: the cortical, responsible for positive selection of T cells, and the medullary, for negative selection. When adipose tissue infiltrates the thymus, thymic adipocytes are pro-inflammatory, knocking out T-cell output. Likewise, systemic inflammation, or “inflammaging,” from smoking, obesity, and chronic stress promote thymic adipocytes. Now, from preclinical studies, we know about key pathways that account for these processes. Historically, back in 2014, FOXN1 was recognized as a single master transcription factor essential for TEC function, with studies in mice with forced FOXN1 upregulation leading to thymus regeneration. That laid the foundation for potential regrowth of quiescent thymus cells. It took awhile to find pathways to accomplish this goal and to even refute its role as the master regulator. The Liver-Thymus Axis Feng Zhang and his team recently showed that injection of an mRNA vaccine to the liver encoding DLL1, IL-7 and FLT3-L in combination, factors known to support thymopoiesis (Figure), successfully enhanced immune function in aged mice. However, the effect was transient. The FGF21 Story Two reports in 2025 addressed the thymus gland’s production of FGF21, a growth factor (fibroblast growth factor 21) and its control of thymus involution. This growth factor is also produced by the liver, but it doesn’t have impact on the thymus in aged rodent models. In contrast, The liver’s hepatocyte growth factor (HGF) has been shown to reverse senescent TEC structural changes. Growth hormone stimulates production of insulin growth factor-1 (IGF-1) in the liver and the thymus. Two small studies in human participants (TRIIM, for Thymus Regeneration, Immunorestoration, and Insulin Mitigation) of 6 and 50 people, respectively, treated with combined human growth hormone, metformin and DHEA, suggested the potential of slowing epigenetic aging and improving thymus mass and function. But the combination of drugs, small sample, and lack of controls make conclusions murky. Increased thymus FGF21 led to increased CD8 T cells in old mice and extended healthspan and improved physical performance. Building on the previous FOXN1 data, ablation of β-klotho, the obligatory co-receptor for FOXN1, accelerated thymic aging. The benefit to FGF21 was confirmed in a companion paper using an FGF21 knock-in mouse model showing thymus enlargement and increased TECs throughout the lifespan. (schematic Figure below). The accompanying editorial for these 2 papers speculated: “The proposed link between age-associated thymus involution and organismal aging is intriguing, and suggests we might seek to achieve systemic rejuvenation by counteracting thymic involution.” Other Factors Lessons from the Axolotl (Mexican Salamander) In an elegant set of experiments of the axolotl (Figure), known for its complete thymus regeneration after total surgical removal, mediators were identified. Surprisingly FOXN1 was dispensable. But midkine, a growth factor, appeared to be the driver, the initiator of thymus cell growth, survival, and repair. Other components that contributed were Postn+ (periostin-expressing mesenchymal niches) and Ccl19, a chemokine protein from the bloodstream. RANK and RANKL RANK (receptor activator of nuclear factor κB its ligand (RANKL) have been considered key regulators of medullary TECs. In a study of both aged mice and human thymus cell cultures, their key role was confirmed, with multiple benefits of resorting TEC function, recruitment of progenitor cells, and T cell development. Subscribe Summing Up This body of work strongly supports the health of the thymus gland as a critical regulator of human healthspan, not just a correlate or link. The new landmark studies are reinforced by the regenerative biology experimental models that have shown, via an array of mediators, that healthspan of aged mice is at least in part dependent on thymus gland function and its critical role for maintaining adaptive immunity. It sure seems that we’d be better off having an immune reservoir of naive T cells instead of a profile in older adults of exhausted, low quality, memory T cells, with a senescent phenotype. It is striking that we ignored the importance of the thymus gland for many decades. A wake-up call was the results of the thymectomy matched control study reviewed here, with the opposite of high thymic health score improved health outcomes. The convergence of AI and healthspan here is notable. The exceptional and laborious work for developing and validating (no less explaining) the AI to quantify thymus health set the foundation for probing the connect the major health outcomes in two cohorts with extensive follow-up. We’ve never had a way to meaningfully quantify the thymus gland before, so this represents important leverage of supervised, self-supervised, and transformer models. The study wouldn’t have been possible without AI. And it begs the question as to whether there are ways we can maintain our thymus at a high health score. But it’s not so simple to rejuvenate our thymus. There are multiple risks including the induction of autoimmunity, increasing the risk of cancer, and inducing a pro-inflammatory state. For example, factors that increase TEC proliferation could compromise the medulllary negative selection process and leak out auto-reactive (self-attacking) T cells. Thymic cells could be induced to proliferate, but we know, for example, that growth hormone and IGF-1 are associated with an increase risk of cancer. If thymus rejuvenation doesn’t clear out the accumulated senescent cells in older adults, then inflammation within the gland could block the production of TECs. Keeping these risks in mind, we now have identified many ways to keep our thymus healthy as we age that undoubtedly will be tested in clinical trials going forward. Ultimately, the benefit-to-risk tradeoffs will be defined. In the meantime, we have desperately needed an immunome. As I’ve stressed in multiple prior Ground Truths, we have no test in the clinic to assess a patient’s immune status! It was very encouraging for me to get an email from Hugo Aerts, the senior author of the landmark papers in the days after they were published: “I also wanted to say that your Substack on “Why We Need an Immunome” was inspiring for this work. We found it a very compelling perspective and greatly enjoyed reading it.” Just having an assessment of a person’s immune status via a chest CT scan, with millions of these performed per year, might help in guiding the right immunotherapy for cancer (e.g. more intensive, combinations for those with low thymic health scores) and help define people who are increased risk for age-related diseases of cancer, cardiovascular, and neurodegenerative. The main theme of Super Agers is that we now have many layers of data (genetics, proteins, biomarkers, organ clocks that can be integrated via multimodal AI) for us to define a person’s specific risk decades before one of these age-related diseases leads to symptoms, enabling prevention. From the new studies this week, we can add thymus health score as yet another way to understand a person’s risk, a window into their adaptive immune system and healthspan. And perhaps someday we will be able to safely rejuvenate the thymus, or maintain its health through one’s life, and use the thymus health score to monitor. NB: I wrote this post (No A.I.) A Quick Poll Loading... ********************************************************************* Thanks to Ground Truths subscribers (now > 200,000) from every US state and 212 countries. Your subscription to these free essays and podcasts makes my work in putting them together worthwhile. Please join! If you found this interesting PLEASE share it! Share Ground Truths Paid subscriptions are voluntary and all proceeds from them go to support Scripps Research. They do allow for posting comments and questions, which I do my best to respond to. Please don’t hesitate to post comments and give me feedback. Let me know topics that you would like to see covered. Leave a comment Many thanks to those who have contributed—they have greatly helped fund our summer internship programs for the past two years. It enabled us to accept and support 47 summer interns in 2025! We aim to accept even more of the several thousand who will apply for summer 2026.

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Mar 22 • 2:18 PM EDT • Health • erictopol.substack.com
Kentucky vs. Iowa State odds, time, March Madness predictions: 2026 NCAA Tournament picks from proven model

SportsLine's model has revealed its Kentucky vs. Iowa State picks for the NCAA Tournament 2026 second-round game on Sunday

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Mar 22 • 1:03 PM EDT • Sports • cbssports.com
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NCAA men's bracket live updates, scores: Purdue vs. Miami leads off March Madness Sunday; Duke, Florida, UConn return to court
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Mar 22 • 12:46 PM EDT • Sports • sports.yahoo.com
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Messi expected to play, NYCFC vs. Inter Miami live updates

Lionel Messi and Inter Miami shift their focus to MLS play with a matchup against New York City FC at Yankee Stadium on Sunday, March 22.

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Mar 22 • 11:45 AM EDT • Sports • usatoday.com
Arsenal vs. Manchester City live stream: How to watch EFL Cup final, odds, start time

This is Pep Guardiola's best chance at a trophy this season, and perhaps shift the momentum in the Premier League

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Mar 22 • 11:09 AM EDT • Sports • cbssports.com
The Cincinnati's Favorite Beer 2026 winner is ... (drumroll please)

Our new beer bracket champ had a difficult path to the crown. The final suds match was Vlad (Fretboard) vs. Dunkel (Hofbrauhaus). So, who won!?

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Mar 22 • 10:58 AM EDT • Entertainment • cincinnati.com
Purdue vs Miami live updates: Prediction, how to watch March Madness Round 2 game

Braden Smith has the NCAA assists record, now he can focus on his main goal: a championship. Miami stands in Purdue's way in Round 2 of March Madness.

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Mar 22 • 9:44 AM EDT • Sports • usatoday.com
Intel compares Core Ultra 200S Plus to Ryzen 9600X and 9700X, gaming uplift stays small

Intel Core Ultra 200S Plus is aimed at creators, not gaming Intel has updated its pre-briefing deck ahead of Core Ultra 200S Plus reviews, and one of the

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Mar 22 • 8:00 AM EDT • Technology • videocardz.com
Golden Knights intent on igniting sluggish offense vs. Stars

With 12 games left in the regular season, it's fair to say that things are trending in the wrong direction for the Vegas Golden Knights.

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Mar 22 • 7:49 AM EDT • Sports • cbssports.com
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Game Preview: Carolina Hurricanes @ Pittsburgh Penguins 3/22/2026

Who: Carolina Hurricanes (44-19-6, 94 points, 1st place Metropolitan Division) @ Pittsburgh Penguins (35-18-16, 86 points, 2nd place Metropolitan Division) When: 3:00 p.m. eastern How to Watch: Locally broadcast on Sportsnet Pittsburgh and FDSN South, streaming on ESPN+ Pens’ Path Ahead: Quality opponents await in the next week; the Pens host Colorado on Tuesday, an Avs team […]

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Mar 22 • 6:00 AM EDT • Sports • sports.yahoo.com
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Duke vs Baylor predictions, picks, odds for NCAA Tournament Second Round

Our March Madness experts pick the winner for No. 3 Duke vs No. 6 Baylor in the 2026 women's NCAA Tournament on March 22

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Mar 22 • 5:08 AM EDT • Sports • usatoday.com
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Where to watch Minnesota vs. Ole Miss in March Madness Second Round: Time, TV Channel

The No. 4 Minnesota Golden Gophers face the 5 Ole Miss Rebels in the Second Round of the women's NCAA Tournament. Here's how to see all the action.

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Mar 22 • 5:06 AM EDT • Sports • usatoday.com
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Where to watch Duke vs. Baylor in March Madness Second Round: Time, TV Channel

The No. 3 Duke Blue Devils face the 6 Baylor Bears in the Second Round of the women's NCAA Tournament. Here's how to see all the action.

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Mar 22 • 5:06 AM EDT • Sports • usatoday.com
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Where to watch Oklahoma vs. Michigan State in March Madness Second Round: Time, TV Channel

The No. 4 Oklahoma Sooners face the 5 Michigan State Spartans in the Second Round of the women's NCAA Tournament. Here's how to see all the action.

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Mar 22 • 5:06 AM EDT • Sports • usatoday.com
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Warriors drop third straight with 126-110 loss vs. Hawks

The Warriors had no answer for Dyson Daniels, CJ McCollumn and the Hawks on Saturday in a 126-110 loss.

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Mar 22 • 4:13 AM EDT • Sports • sports.yahoo.com
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The Business of Football: How many players do you need to win a World Cup anyway?

The English FA and the Premier League are having another row, as the club vs country debate rages on in English football

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Mar 22 • 12:02 AM EDT • Business • nytimes.com
UCLA overcomes broken tooth and stubborn UCF 75-71

UCLA remains in the hunt for a 12th national championship

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Mar 21 • 8:08 PM EDT • Sports • spectrumlocalnews.com
Movsar Evloev vs. Lerone Murphy full fight video highlights

Movsar Evloev wins close call against Lerone Murphy at UFC London

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Mar 21 • 7:28 PM EDT • Sports • sports.yahoo.com
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Arkansas vs High Point live updates: March Madness Round 2 game highlights, how to watch

We're running out of Cinderellas. Will the slipper still fit for High Point? Arkansas and Darius Acuff Jr. will have something to say about that.

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Mar 21 • 7:27 PM EDT • Sports • usatoday.com
UFC London live blog: Movsar Evloev vs. Lerone Murphy

Follow along for live updates on Movsar Evloev vs. Lerone Murphy at UFC London

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Mar 21 • 6:33 PM EDT • Sports • sports.yahoo.com
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Illinois vs VCU live updates: March Madness Round 2 game highlights, how to watch

VCU's upset of North Carolina was a highlight of March Madness Round 1. What do Rams have in store for Illinois in Round 2? Follow our live updates.

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Mar 21 • 6:08 PM EDT • Sports • usatoday.com
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UFC Fight Night odds, lines, predictions, time: Evloev vs. Murphy picks from proven MMA expert

Expert Kyle Marley reveals his UFC Fight Night best bets for the March 21 London card on Paramount+

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Mar 21 • 1:21 PM EDT • Sports • cbssports.com
Rockets to utilize tweaked starting lineup vs. Heat

Rockets to utilize tweaked starting lineup vs. Heat

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Mar 21 • 10:25 AM EDT • Sports • cbssports.com
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UFC Fight Night odds, lines, predictions, time: Evloev vs. Murphy picks from proven MMA expert

Expert Kyle Marley reveals his UFC Fight Night best bets for the March 21 London card on Paramount+

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Mar 21 • 8:46 AM EDT • Sports • cbssports.com
No. 4 Arkansas keeping guard up vs. Cinderella High Point

No. 4 Arkansas keeping guard up vs. Cinderella High Point

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Mar 21 • 8:39 AM EDT • Sports • cbssports.com
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Duke vs. TCU odds, March Madness predictions: 2026 NCAA Tournament picks from proven model

SportsLine's model has revealed its Duke vs. TCU picks for the NCAA Tournament 2026 second-round game on Saturday

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Mar 21 • 8:32 AM EDT • Sports • cbssports.com
March Madness games today: Ranking the 16-game Women's NCAA Tournament schedule for Saturday

Syracuse vs. Iowa State and Princeton vs. Oklahoma State leads the best Women's NCAA Tournament games to watch on Saturday.

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Mar 21 • 8:24 AM EDT • Sports • usatoday.com
Roomette vs. bedroom on Amtrak's California Zephyr train

I compared the roomette and bedroom accommodations on the California Zephyr, an overnight Amtrak train. The bedroom was twice as big.

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Mar 21 • 7:42 AM EDT • Business • businessinsider.com
Where to watch UConn vs. UTSA in March Madness First Round: Time, TV Channel

The No. 1 UConn Huskies face the 16 UTSA Roadrunners in the First Round of the women's NCAA Tournament. Here's how to see all the action.

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Mar 21 • 5:07 AM EDT • Sports • usatoday.com
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West Virginia vs Miami (OH) predictions, picks, odds for NCAA Tournament First Round

Our March Madness experts pick the winner for No. 4 West Virginia vs No. 13 Miami (OH) in the 2026 women's NCAA Tournament on

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Mar 21 • 5:06 AM EDT • Sports • usatoday.com
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Vaz and Tsimikas to start vs Lecce

Good attacking depth and a knack for jostling opponents. Plus, an assist and a penalty won. It may not have been enough to eliminate Bologna from the Europa League, but it might have been enough to co...

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Mar 21 • 4:45 AM EDT • Sports • sports.yahoo.com
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LIVE: Japan vs Australia – Women’s Asian Cup 2026 final

Follow our live build-up, with team news, ahead of our text commentary stream of the Women's Asian Cup final.

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Mar 21 • 2:01 AM EDT • Sports • aljazeera.com
Wine vs beer vs spirits: Which is the least bad for your health?

A study of 340,000 adults suggests not all alcohol carries the same risk - even at low to moderate levels, beer, cider and spirits were linked to higher mortality, while wine was associated with a lower risk.

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Mar 21 • 2:00 AM EDT • Health • euronews.com
Open-world adventure game CookieRun: New World announced for console, PC, and mobile

Devsisters has announced CookieRun: New World, an open-world adventure game based on the CookieRun mobile game franchise with over 300 million players and more than $1 billion in lifetime revenue. …

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Mar 20 • 10:48 PM EDT • Technology • gematsu.com
California Health Sciences University medical student celebrates full-circle moment on Match Day

Friday was a big day for medical students across the country. It's Match Day.

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Mar 20 • 9:30 PM EDT • Health • abc30.com
Ivan Herrera Hits First Home Run of Spring Training
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Mar 20 • 9:17 PM EDT • Sports • sports.yahoo.com
Good Sports: El Capitan High School baseball players commit to college together

Cooper Gaoiran and Zach Hunter have always been a package deal. That's been the case for as long as they remember, all the way back to t-ball.

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Mar 20 • 8:45 PM EDT • Sports • abc30.com
Michigan vs Saint Louis prediction, picks, odds for NCAA Tournament Second Round

Our March Madness experts pick the winner for No. 1 Michigan vs No. 9 Saint Louis in the 2026 NCAA Tournament on March 21

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Mar 20 • 8:21 PM EDT • Sports • usatoday.com
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Gonzaga vs Texas prediction, picks, odds for NCAA Tournament Second Round

Our March Madness experts pick the winner for No. 3 Gonzaga vs No. 11 Texas in the 2026 NCAA Tournament on March 21

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Mar 20 • 6:41 PM EDT • Sports • usatoday.com
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Trump weighing several options for U.S. troops inside Iran

Discussions about possible ground troops have focused on missions aimed at escalating the war in attempt to end it, sources say, but no decisions have been made.

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Mar 20 • 5:11 PM EDT • Politics • nbcnews.com
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Texas vs Missouri State predictions, picks, odds for NCAA Tournament First Round

Our March Madness experts pick the winner for No. 1 Texas vs No. 16 Missouri State in the 2026 women's NCAA Tournament on March 20

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Mar 20 • 3:50 PM EDT • Sports • usatoday.com
Texas Tech vs Villanova predictions, picks, odds for NCAA Tournament First Round

Our March Madness experts pick the winner for No. 7 Texas Tech vs No. 10 Villanova in the 2026 women's NCAA Tournament on March 20

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Mar 20 • 3:21 PM EDT • Sports • usatoday.com
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