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From radio to newsreels to Netflix, Yankees chart course through entertainment history
For more than a century, the Yankees have been more than a baseball team. The sport’s most storied franchise is a pop culture touchstone, a versatile backdrop that serves as both a symbol of excellence and a punchline across television, movies and more. So as the Yankees prepare to break
Microsoft-backed startup raises $40 million for advanced chipmaking equipment tech
Lace, a Norway-headquartered chipmaking equipment startup which is backed by Microsoft, has raised $40 million in funding to further develop a technology that could enable significant advances in semiconductor design and manufacturing, the company said on Monday. To make cutting-edge chips, manufacturers such as Taiwan Semiconductor Manufacturing Co and Intel employ a process called lithography that uses light to draw complex circuits that form the foundation of advanced artificial intelligence chips. Manufacturers use light-based lithography systems made by the Dutch company ASML - which dominates the market - as they race to shrink chip components and squeeze in more features to boost the computing horsepower on a limited area of silicon.
2026 MLB standings predictions: Expert picks for every division, full projections as baseball season begins
Here are the predictions from our CBS Sports MLB staff for the 2026 season
Google TV just lost a big TV brand to web app-based ‘Titan OS’
Philips, a major TV brand in markets such as the UK and Europe, is ditching Google TV for “Titan OS.”...
Firefox 149 Now Available With XDG Portal File Picker, Rust-Based JPEG-XL Decoder
Firefox 149.0 release binaries are now available with a wide assortment of improvements for this month's update to the cross-platform Mozilla web browser solution.
2026 Fantasy Baseball Rankings: Sleepers, busts, breakouts from model that nailed Cal Raleigh's epic season
SportsLine simulated the entire MLB season 10,000 times and identified 2026 Fantasy baseball sleepers, breakout and busts
Health in a Handbasket: Chips & Dip
Today we're putting a healthy spin on a snack we all know and love.
Microsoft Exchange Online service change causes email access issues
Microsoft is working to address an ongoing service issue that has intermittently prevented some users from accessing their cloud-based Exchange Online mailboxes via Outlook mobile and Mac desktop clients since Thursday.
Here are nearly 100 local high school spring sports stars to watch
Spring sports are rich with talented athletes. From baseball to track and soccer to swimming, here are nearly 100 Fort Collins-area stars to watch.
“It’s a bit of an event. It’s not a sport” - Kevin Garnett thinks the modern NBA is more entertainment than competition
Kevin Garnett says NBA has become entertainment-driven.
Health care advisory Chartis brings AI development engine in-house to build tools for clients
With the acquisition of artificial intelligence incubator Leap AI, Chicago-based Chartis’ health care advisers will move from making suggestions about AI to rolling up their sleeves and building custom AI solutions.
Scouting Michigan State basketball Sweet 16 matchup with UConn
Get a first glimpse at the NCAA Tournament East region Sweet 16 semifinal matchup between 3-seed Michigan State basketball and 2-seed UConn.
In California, a Republican Sheriff Seizes Ballots, Prompting Concerns
Riverside County Sheriff Chad Bianco, a candidate for governor, recently took possession of more than 650,000 ballots as part of a fraud probe. Election officials say his investigation is baseless.
Palm Beach County high school sports weekly schedule for March 23-28
High school sports are back in full swing in Palm Beach County. See the full schedule for baseball, softball, lacrosse and more.
Tribune All-Area girls' basketball team full of winners
2025-26 Tribune All-Area girls' basketball team features a group of winners, boasting a ton of talent on the hardwood.
Best selling author Marie Benedict to talk at the United Theatre
WESTERLY — Marie Benedict, the Pittsburgh-based author known for using real — mostly forgotten — women as inspiration for her bestselling works of historical fiction, was on the phone Tuesday
Opinion | Doctors should be paid to keep patients healthy
Value-based care works best when physicians lead, specialists share accountability, and long-term outcomes matter.
River Cats top Giants in exhibition at Sutter Health Park as fans welcome baseball’s return
"Finally, the drought is over between football and the start of baseball."
TCU completes comeback, avoids Washington's NCAA Tournament upset bid
TCU women's basketball’s 62-59 overtime win over Washington in the second round of March Madness wasn’t pretty, but it was resilient.
Dean for Basic Science Colin Duckett tapped to serve as Boston University Provost
Duckett, executive vice dean for basic and preclinical science, will begin his tenure as chief academic officer at Boston University starting in July.
Michigan State basketball time, TV channel set for Sweet 16
Michigan State basketball knows when it will be playing, even before it knows its opponent in the Sweet 16 in Washington on Friday night.
Samsung reverses big S Pen change for Galaxy S27 Ultra after bold experiment fails
Samsung has backed away from one of its more ambitious S Pen experiments for next year’s Galaxy S27 Ultra, choosing to stick with its long-standing digitizer-based input system after testing a radically thinner alternative. According to ETNews, Samsung had been exploring a new pen technology that could eliminate the digitizer layer inside the display. The […]
Kansas coach Bill Self non-committal if he'll return next year due to health concerns
Hall of Fame Kansas basketball coach Bill Self said after a crushing loss to St. John's that he hasn't decided if he'll be back next season or retire.
Bill Self says coaching future at Kansas to be determined
Longtime Kansas coach Bill Self said after Sunday's season-ending loss to St. John's that he has not yet made a decision about his coaching future, later adding that any decision will be based solely on his health.
Florida basketball stunned by Iowa in March Madness Round 2 upset
Florida basketball was stunned by Iowa, ending its hopes to repeat as national champions in the Men's NCAA Tourrnament.
Jerry Hanlon, longtime Michigan football coach, dies at 96
"Michigan Athletics has lost one of the finest ambassadors and mentors our football program has ever known," U-M AD Warde Manuel said in a statement.
The M-Trends 2026 report shows how to strengthen business cybersecurity.
Learn more about the evolving threat landscape based on Mandiant's new M-Trends 2026 cybersecurity report.
Locally-based behavioral health group to open first Louisville office
The location will provide individual, couples and family therapy.
‘We’ve got some unfinished business’: Corey Gipson reflects on historic Austin Peay season
Austin Peay men's basketball head coach Corey Gipson recently reflected on his 2025-26 season and revealed what makes Clarksville special.
CBS analyst picked against Purdue basketball. Here's what he thinks of Sweet 16 vs Texas
Boilermakers fans were critical of Seth Davis for his pick proven wrong after Purdue beat Miami. Here's what he thinks of the Sweet 16 game vs Texas.
The OG Four-Door Porsche Sports Sedan Wasn't Even Built By Porsche
In 1967, a Texas-based car dealer wanted a four-door Porsche 911 S. Porsche wouldn't make it, so he turned to coachbuilders for help.
The Times' top 25 high school baseball rankings
St. John Bosco and Sherman Oaks Notre Dame remain unbeaten in high school baseball
Your Thymus and Your Healthspan
Our thymus gland plays a central role in the development or our immune system, specifically for supporting T cell development (how these cells got their name, maturation and differentiation in the thymus) and discriminating between self and foreign, non-self antigen proteins with production of dendritic cells. As we age, our thymus gland shrinks—the process known as involution—with progressive change from spongy to fatty tissue, with loss of functionality. But this process, with respect to timeline and extent, markedly varies from one person to the next. And to make things even more complicated, our thymus gland anatomy and precise location in the chest also is highly variable. So the famous Frank Netter diagrams from the 1960s (such as at left below) don’t capture the remarkable heterogeneity that a random set of 12 chest CT scans (below at right). What I consider as 2 landmark papers in Nature this week (here and here) used AI to quantify health of the thymus in 2 large cohorts, and then correlate the metric to a broad array of health outcomes. In this edition of Ground Truths, I’m going to cover three questions: (1) How was thymus health determined by AI?; (2) How is thymus health linked to key clinical outcomes? and (3) Are there ways we can promote a healthy (aka rejuvenate) thymus gland in our later years? Subscribe 1. How was thymus health determined by AI? This was accomplished by extensive work developing and validating an AI pipeline for 2 stages, the first for localization and segmentation of the thymus bed, and the second to quantify a digital marker, termed the thymic health score. There’s a lot to this algorithmic development, so I won’t go into all the details, but just provide a rudimentary outline of what was done. The 1st stage used supervised learning with 2 radiologists reviewing 2,461 chest CT scans. That work trained a 3D U-Net model to automatically identify the thymic bed’s 3D cropped region using center of mass coordinates, which reached 99.8% accuracy. The 2nd stage used a foundation model that was pre-trained with SwAV (which stands for Swapping Assignment between multiple Views), a self-supervised model, that generated a high-dimensional thymus representation of 4,096 features. That compares to the radiology reductionist and subjective scoring of 0 to 3 where 0 means the thymus is fully degenerated and fatty, and 3 is considered dense, intact glandular soft tissue. Notably, the self-supervised learning (SSL) performance was superior to supervised (AUC ~0.75 vs 0.55, respectively) reflecting the shallowness of the 0-3 classifier vs SSL’s holistic, self-taught AI. The thymic health score ranged from 0 to 100, with the highest number indexed to fully preserved thymic health. The algorithmic work extended to explainability with both Shapely value distribution, meaning the model was holistic not relying on any “magic” pixel, and occlusion sensitivity, demonstrating the model’s performance was not affected by ribs, sternum, lung tissue, but rather focused on the thymic bed directly. Below are a few saliency maps from the occlusion sensitivity that indicate the thymic bed focus, not affected by neighboring structures, using the jet color scale. Now the AI was ready for processing ~25,000 CT scans, each over 30 MB files, from the 2 large participant cohorts to provide a thymic health score, it did so in less than 14 hours, which is less than 2 seconds per scan! Share 2. How is thymus health linked to key clinical outcomes? The two cohorts were the National Lung Screening Trial, NLST (N=25,031) and the Framingham Heart Study, FHS (N=2,581) each with baseline demographics and long term follow up of >12 years for health outcomes. From the NSLT, you can see below that increased age and body-mass index were correlated to reduced thymic health. And, overall, men had reduced thymic health scores compared with women. There are a lot of graphs in the paper for outcomes, for both the NLST and FHS cohorts. To simplify the major outcomes, below is a composite Figure with striking reduction of all-cause mortality and for the different causes of death. The results were consistent between the 2 cohorts. For example, the cardiovascular mortality hazard ratio average was 0.57 in NLST and 0.38 in FHS (weighted to be 0.53 for the aggregate). The reduction of mortality also extended to digestive diseases and pulmonary disease (data not shown below). Lung cancer incidence was reduced by 36% for high vs low thymic health (Figure below, with a panel -incidence and b panel-mortality, adjusted for age, sex, BMI, smoking status). Notably, there was a smoker’s paradox: lower incidence and improved survival for lung cancer in smokers who had a high thymus health score. Smoking was associated with lower thymic scores whereas alcohol was not. Higher thymic health was linked to higher HDL cholesterol, lower triglycerides, lower fasting blood glucose, and lower systolic and diastolic blood pressure. Inflammation biomarkers, such as C-reactive protein and interleukin-6, were elevated in the people with lower thymic health scores. In their second paper, the same team looked at the relationship between thymic score and outcomes for 3,476 patients receiving cancer immunotherapy. The non-small cell lung cancer progression-free survival was reduced in patients with low thymic health score. A parallel relationship for survival was seen for other types of cancer including melanoma, breast, and kidney with a 44% lower risk among high thymic scores (Figure). A similar pattern was seen with different immune checkpoint inhibitors. The thymus health score outperformed programmed death ligand-1 (PD-L1)and tumor mutation burden (TMB) assay of the tumor and was an independent prognostic marker of progression-free survival. In this dataset, a direct connect with thymus score and adaptive immune function was noted with a correlation before cancer treatment for both T-cell diversity and thymus T-cell production (a metric known as T cell receptor excision circles). Thymus Removal Study There is a highly relevant citation about thymus function before moving onto ways to rejuvenate it. In 2023, a very important study of thymus removal during cardiothoracic surgery was published, with 1146 patients undergoing thymus removal vs 1146 matched controls (mean age 55 years). The adverse outcomes for thymus removal were striking, with a 2.9 higher risk of all-cause mortality and doubling of cancer incidence, 1.5 fold increase in cancer mortality, and 1.5-fold increase in autoimmune diseases. The immune function showed marked compromise after thymus removal, as reflected by CD4+ and CD8+ T cells (Figure below) Share Ground Truths 3. Are there ways we can promote a healthy (aka rejuvenate) thymus gland in our later years? In recent months we’ve learned a lot about the process of thymus involution and the pathways by which this may be modulated. Thymus involution is primarily due to loss to thymus epithelial cells (TECs) and there are 2 subtypes with different functions: the cortical, responsible for positive selection of T cells, and the medullary, for negative selection. When adipose tissue infiltrates the thymus, thymic adipocytes are pro-inflammatory, knocking out T-cell output. Likewise, systemic inflammation, or “inflammaging,” from smoking, obesity, and chronic stress promote thymic adipocytes. Now, from preclinical studies, we know about key pathways that account for these processes. Historically, back in 2014, FOXN1 was recognized as a single master transcription factor essential for TEC function, with studies in mice with forced FOXN1 upregulation leading to thymus regeneration. That laid the foundation for potential regrowth of quiescent thymus cells. It took awhile to find pathways to accomplish this goal and to even refute its role as the master regulator. The Liver-Thymus Axis Feng Zhang and his team recently showed that injection of an mRNA vaccine to the liver encoding DLL1, IL-7 and FLT3-L in combination, factors known to support thymopoiesis (Figure), successfully enhanced immune function in aged mice. However, the effect was transient. The FGF21 Story Two reports in 2025 addressed the thymus gland’s production of FGF21, a growth factor (fibroblast growth factor 21) and its control of thymus involution. This growth factor is also produced by the liver, but it doesn’t have impact on the thymus in aged rodent models. In contrast, The liver’s hepatocyte growth factor (HGF) has been shown to reverse senescent TEC structural changes. Growth hormone stimulates production of insulin growth factor-1 (IGF-1) in the liver and the thymus. Two small studies in human participants (TRIIM, for Thymus Regeneration, Immunorestoration, and Insulin Mitigation) of 6 and 50 people, respectively, treated with combined human growth hormone, metformin and DHEA, suggested the potential of slowing epigenetic aging and improving thymus mass and function. But the combination of drugs, small sample, and lack of controls make conclusions murky. Increased thymus FGF21 led to increased CD8 T cells in old mice and extended healthspan and improved physical performance. Building on the previous FOXN1 data, ablation of β-klotho, the obligatory co-receptor for FOXN1, accelerated thymic aging. The benefit to FGF21 was confirmed in a companion paper using an FGF21 knock-in mouse model showing thymus enlargement and increased TECs throughout the lifespan. (schematic Figure below). The accompanying editorial for these 2 papers speculated: “The proposed link between age-associated thymus involution and organismal aging is intriguing, and suggests we might seek to achieve systemic rejuvenation by counteracting thymic involution.” Other Factors Lessons from the Axolotl (Mexican Salamander) In an elegant set of experiments of the axolotl (Figure), known for its complete thymus regeneration after total surgical removal, mediators were identified. Surprisingly FOXN1 was dispensable. But midkine, a growth factor, appeared to be the driver, the initiator of thymus cell growth, survival, and repair. Other components that contributed were Postn+ (periostin-expressing mesenchymal niches) and Ccl19, a chemokine protein from the bloodstream. RANK and RANKL RANK (receptor activator of nuclear factor κB its ligand (RANKL) have been considered key regulators of medullary TECs. In a study of both aged mice and human thymus cell cultures, their key role was confirmed, with multiple benefits of resorting TEC function, recruitment of progenitor cells, and T cell development. Subscribe Summing Up This body of work strongly supports the health of the thymus gland as a critical regulator of human healthspan, not just a correlate or link. The new landmark studies are reinforced by the regenerative biology experimental models that have shown, via an array of mediators, that healthspan of aged mice is at least in part dependent on thymus gland function and its critical role for maintaining adaptive immunity. It sure seems that we’d be better off having an immune reservoir of naive T cells instead of a profile in older adults of exhausted, low quality, memory T cells, with a senescent phenotype. It is striking that we ignored the importance of the thymus gland for many decades. A wake-up call was the results of the thymectomy matched control study reviewed here, with the opposite of high thymic health score improved health outcomes. The convergence of AI and healthspan here is notable. The exceptional and laborious work for developing and validating (no less explaining) the AI to quantify thymus health set the foundation for probing the connect the major health outcomes in two cohorts with extensive follow-up. We’ve never had a way to meaningfully quantify the thymus gland before, so this represents important leverage of supervised, self-supervised, and transformer models. The study wouldn’t have been possible without AI. And it begs the question as to whether there are ways we can maintain our thymus at a high health score. But it’s not so simple to rejuvenate our thymus. There are multiple risks including the induction of autoimmunity, increasing the risk of cancer, and inducing a pro-inflammatory state. For example, factors that increase TEC proliferation could compromise the medulllary negative selection process and leak out auto-reactive (self-attacking) T cells. Thymic cells could be induced to proliferate, but we know, for example, that growth hormone and IGF-1 are associated with an increase risk of cancer. If thymus rejuvenation doesn’t clear out the accumulated senescent cells in older adults, then inflammation within the gland could block the production of TECs. Keeping these risks in mind, we now have identified many ways to keep our thymus healthy as we age that undoubtedly will be tested in clinical trials going forward. Ultimately, the benefit-to-risk tradeoffs will be defined. In the meantime, we have desperately needed an immunome. As I’ve stressed in multiple prior Ground Truths, we have no test in the clinic to assess a patient’s immune status! It was very encouraging for me to get an email from Hugo Aerts, the senior author of the landmark papers in the days after they were published: “I also wanted to say that your Substack on “Why We Need an Immunome” was inspiring for this work. We found it a very compelling perspective and greatly enjoyed reading it.” Just having an assessment of a person’s immune status via a chest CT scan, with millions of these performed per year, might help in guiding the right immunotherapy for cancer (e.g. more intensive, combinations for those with low thymic health scores) and help define people who are increased risk for age-related diseases of cancer, cardiovascular, and neurodegenerative. The main theme of Super Agers is that we now have many layers of data (genetics, proteins, biomarkers, organ clocks that can be integrated via multimodal AI) for us to define a person’s specific risk decades before one of these age-related diseases leads to symptoms, enabling prevention. From the new studies this week, we can add thymus health score as yet another way to understand a person’s risk, a window into their adaptive immune system and healthspan. And perhaps someday we will be able to safely rejuvenate the thymus, or maintain its health through one’s life, and use the thymus health score to monitor. NB: I wrote this post (No A.I.) A Quick Poll Loading... ********************************************************************* Thanks to Ground Truths subscribers (now > 200,000) from every US state and 212 countries. Your subscription to these free essays and podcasts makes my work in putting them together worthwhile. Please join! If you found this interesting PLEASE share it! Share Ground Truths Paid subscriptions are voluntary and all proceeds from them go to support Scripps Research. They do allow for posting comments and questions, which I do my best to respond to. Please don’t hesitate to post comments and give me feedback. Let me know topics that you would like to see covered. Leave a comment Many thanks to those who have contributed—they have greatly helped fund our summer internship programs for the past two years. It enabled us to accept and support 47 summer interns in 2025! We aim to accept even more of the several thousand who will apply for summer 2026.
Syracuse reportedly targeting former player Gerry McNamara as its next men's basketball coach
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From shirts featuring new players to hats in every color, Poor Boys Sports has all your Orioles merch needs for Opening Day.
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The 2026 NCAA Men’s Basketball Tournament continues with the Round of 32 on Sunday, and we've got you covered with all the highlights!
Bash: Trump celebrating Mueller’s death ‘not a surprise, but that doesn’t make it okay’
‘Project Hail Mary’ Author Andy Weir Bases His Blockbusters in Science
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Sebastian Kehl exits role as Borussia Dortmund sporting director
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The best seafood restaurant in every state, according to Yelp
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Acuff scores 36 as Arkansas holds off No. 12 seed High Point 94-88
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Scientists discover surprising brain trigger behind high blood pressure
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German club Borussia Dortmund parts ways with sports director Kehl
German football club Borussia Dortmund said on Sunday it is ending its collaboration with sports director Sebastian Kehl with immediate effect.
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Girls' basketball coach of the year: Alicia Komaki of Sierra Canyon
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How investors use the BRRRR strategy to scale real estate portfolios
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What time is Michigan women's basketball's second round game?
Michigan cruised to a blowout victory over Holy Cross in their opening NCAA Women's Tournament matchup. See who they play next.
A Grip on Sports: In a season when Gonzaga's defense was the driving force behind its success, the Zags couldn't get the one stop they needed
A GRIP ON SPORTS • After all the flotsam and jetsam is swept away, sometimes a college basketball game, an NCAA Tournament game, comes down to making one play. Saturday night in Portland, Texas did. And Gonzaga’s season once again fell short of its ultimate goal.
Spring (Sports) Have Sprung!
QHS takes down QND in Baseball, QND falls to Helias in girls' soccer, and QU falls to UMSL in baseball.
Another Illinois basketball player enters legendary status in NCAA tournament
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Coaches in elite company clash when Kansas faces St. John's
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Business investment in the era of digital transformation
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Four takeaways from Nebraska men’s basketball’s NCAA Tournament win over Vanderbilt
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Iran launched missiles at US-UK military base in the Indian Ocean. Here’s what that says about its capabilities
Iran’s attempt to strike a US-UK base over 2,000 miles (over 3,000 kilometers) off its coast has renewed questions about Tehran’s military capabilities and how far its missiles can reach.
Fantasy baseball updated Reliever rankings for 2026
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Jaebri'an Autry ends Detroit Renaissance career with heartbreak
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Mainieri out as South Carolina's baseball coach in 2nd season
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Who is Jazzy Davidson? True freshman guard leads USC into March Madness
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Minecraft World Opening 2027, First Look at $70 Million Project
Theme park lovers who yearn for the mines will have their wish granted in 2027 with the debut of Minecraft World, based on the popular building video game.
Why Buc-Ee's Received An 'F' Rating From Better Business Bureau
Buc-ee's is a beloved Texas-based gas/convenience store chain with dozens of locations across the U.S. So why did it get an F from the Better Business Bureau?
2026 NCAA Men's Basketball Tournament Highlights: Men's Round of 32, More
March Madness continues Saturday, and we've got you covered with all the must-see moments from start to finish!
High school baseball and softball: Friday's scores
CIF City Section and Southern Section high school baseball and softball scores for Friday's games.
Aspen hosts an eve of storytelling with famed sports photographer
Led by the lens, acclaimed American sports photographer Jean Fruth will share tales from her work covering Major League Baseball and beyond.
Lauren Betts powers UCLA women's basketball in March Madness. What to know about her
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iPhone 18 Pro camera may come with pro software, Apple considered buying Halide
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Letters to Sports: WBC brings joy back to All-Star-level play
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Trump and the politics of death
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The end of the ISS is looming, and the US could have a big problem
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Minnesota Blue Cross CEO steps down from Sutter Health board over conflict of interest
The Eagan-based insurer says CEO Dana Erickson was recused from Sutter board discussions on acquiring Allina Health, which provides care to many Blue Cross members.
Paul Freud on using art to understand wars and politics
The London-based artist and great-grandson of Sigmund Freud discusses forging his own artistic language and finding inspiration in global conflict.
Your 2026 NCAA Basketball Tournament Viewing Guide: March 21, 2026
Bummed about only one men’s tournament game at a time for 6 hours today? THAT’S WHAT THE WOMEN’S TOURNAMENT IS FOR!
Nebraska lands the commitment of 3-star athlete Kaden Howard
The feel-good momentum surrounding the Nebraska athletic department continues to build following the men’s basketball team’s first-round NCAA Tournament victory—and it’s now carrying over onto the recruiting trail. The Cornhuskers have secured a commitment from 3-star athlete Kaden Howard, a 5-foot-10, 160-pound playmaker out of Miami, Florida. Howard picked Nebraska over Louisville, West Virginia and […]
Basketball box scores, other sports results for Friday, March 20, 2026; Playoff schedule
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Open-world adventure game CookieRun: New World announced for console, PC, and mobile
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College student asks Trump’s UN Ambassador: How is a war half a world away, funded by my taxes, helping
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The biggest medieval march in English history never actually happened
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Spring Game #28: Athletics versus Cubs Game Thread
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Nvidia Confirms DLSS 5 Is Re-Drawing Games, and That Sucks
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iOS 26.4 isn't the major update with new Siri features that we hoped for, but there are some useful quality of life improvements, and a little bit of fun with an AI playlist generator and new emoji characters. Playlist Playground - Apple Music has a Playlist Playground option that lets you generate playlists from text-based descriptions. You can include moods, feelings, activities, or make up something entirely nonsensical and let the AI figure out what you mean.
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