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Menopause hormone therapy treatments would be covered by health insurance under Ohio bill
Ohio Democratic lawmakers want menopause hormone therapy treatments covered by health insurance and Medicaid.
UToledo Health Will Kick Off Donate Life Month with a Flag Raising Ceremony
This year’s annual event is in partnership with Life Connection of Ohio and Solvita.
Shohei Ohtani’s Walk-Up Song Revealed Before Opening Day
For Los Angeles Dodgers star Shohei Ohtani's highly-anticipated 2026 season, he is reportedly going back to one of his old walk-up songs.
Ohio State star Caleb Downs addresses controversial injury rumors
Caleb Downs shot down a recent report that he had a degenerative knee condition.
An Artist Lecture and a ‘Science on Screen’ Film Series: 4 Arts Picks for Your Week
Every Thursday, WTTW News newsletter producer Josh Terry highlights his picks for the week’s must-see cultural events.
Wembanyama dominates inside as Spurs trounce Grizzlies 123-98
Victor Wembanyama had 19 points, 15 rebounds and seven blocks as the San Antonio Spurs built an early lead and coasted to a 123-98 victory over the Memphis Grizzlies on Wednesday night. Devin Vassell matched Wembanyama's 19 points, while Stephon Castle and Keldon Johnson finished with 15 points each, as seven Spurs finished in double figures. With its seventh straight victory, San Antonio moved within two games of Oklahoma City for the top spot in the Western Conference as the Boston Celtics stopped the Thunder's 12-game winning streak with a 119-109 victory on Wednesday night.
Central Ohio coffee business fights to keep brewing after farm issue cuts yield
A coffee business rooted in culture and tradition is facing a critical moment.
McCollum well represented in 2026 SA Sports All-Star Basketball Game
Wednesday’s featured players, who will play on Team White, are from McCollum, Harlandale, South San, and John Jay high schools.
Reality TV thrives on messy people — but the Taylor Frankie Paul backlash reveals when audiences finally draw the line
Reality TV thrives on turning personal controversy into entertainment, but Taylor Frankie Paul’s backlash shows the line is crossed when audiences can no longer separate what they’re watching from rea...
The Lancet retracts half-century-old unsigned commentary on talc for undisclosed industry ties
SewcreamStudio/iStock The Lancet has retracted a 49-year-old unsigned commentary on the safety of cosmetic talc after two researchers discovered the author was a paid consultant to Johnson & Jo…
The Institute for Underground Science at SURF Announces 2026 Davis-Bahcall Scholars
The Institute for Underground Science at Sanford Underground Research Facility (SURF) has announced the selected the 2026 cohort of Davis-Bahcall Scholars.
Sonja O'Hara Developing 'Slay' With Producer Scott Glassgold (EXCLUSIVE)
Screenwriter Sonja O'Hara is developing her feature 'Slay' with producer Scott Glassgold following a competition win, Deadline can report exclusively.
Avery County's Hank Johnson leads Week 5 boys spring sports top performers
Avery County's Hank Johnson shot six-under-par to lead the list of Week 5 WNC high school spring sports boys top performers.
Qualified Health's raise comes in at $125M
Axios Pro reported earlier this month the raise would be roughly $100 million.
Africa CDC announces 2026 cohort of Young Digital Health Champions
Addis Ababa, March 23, 2026 — The Youth Digital Health Network (YiDHN), a strategic initiative of Africa CDC’s Youth Division, has announced the 2026 Cohort of Young Digital Health Champions (Y-DHC), recognizing emerging young leaders shaping Africa’s digital health landscape. With over 65% of Africa’s population under the age of 35, investing in youth leadership […]
Sports events in Cleveland expected to generate over $95M in economic impact
The lineup includes 20 major sporting events, which include youth, collegiate and professional levels.
Amusement Entertainment Management Client Wins 2026 FEC of the Year
Star Lanes Polaris of Columbus, Ohio proudly accepted The American Amusement Machine Association’s (AAMA) 2026 Family Entertainment Center Location of the Year Award during the AAMA President…
Florida Democrat flips seat in special election in district that includes Trump’s Mar-a-Lago
Democrat Emily Gregory won a Florida special election on Tuesday, flipping a state legislative district that is home to Mar-a-Lago, the Palm Beach estate that President Donald Trump counts as his residence. The president had endorsed Gregory’s rival, Jon Maples. In a social media post Monday, he urged voters to turn out, saying Maples was backed “by so many of my Palm Beach County friends.” READ MORE: Trump casts Florida ballot by mail as he
Glyphosate: A story of science, risk, and nuance
In the summer of 2014, a California groundskeeper named Dewayne Johnson started noticing patches of raw, weeping skin spreading across his body. He had spent years applying Roundup, Monsanto’s glyphosate-based herbicide, for a school district, sometimes drenched in it when equipment malfunctioned. By 2014, he had a diagnosis: non-Hodgkin’s lymphoma. In 2018, a jury awarded him $289 million in damages, later reduced on appeal. Tens of thousands of lawsuits followed. The story hasn’t quieted down. It’s all over the internet, swinging between “this will kill you, buy organic” and “relax, you’re fear-mongering.” Some of that recent chatter stems from an Executive Order protecting glyphosate and its production, which set off intense infighting within the MAHA movement. Some of it reflects a deeper truth: Americans genuinely care about harmful chemicals in their environment (see poll below). And the conversation isn’t going anywhere, with a Supreme Court case involving Monsanto set for this April. Glyphosate (the active ingredient in Roundup) is one of the most widely used herbicides in the world. But does glyphosate cause cancer? And how much exposure is actually risky? With so much mistrust in institutions and corporations (and some genuine conflicts of interest), making sense of the actual scientific evidence is genuinely hard. Here is a translation of what the scientific evidence actually says. Does glyphosate cause harm? Glyphosate is an herbicide that kills most plants it contacts rather than targeting specific species. It works by blocking an enzyme pathway (EPSPS) that plants and many microorganisms need to produce essential amino acids. Without those amino acids, the plant can’t grow and dies. Glyphosate was first developed by Monsanto in the 1970s and became ubiquitous after the company introduced “Roundup Ready” crops in the 1990s. In 2024, Bayer removed glyphosate from residential Roundup-branded products due to litigation pressure. But today it is still the most widely used herbicide in the world. Farmers also discovered they could spray it directly on crops like oats, lentils, beans, and peas just before harvest to dry them out faster and make harvesting easier. Because of its widespread use, it’s obviously really important to understand if it’s harmful to humans. The key principle: The dose makes the poison The most important concept in toxicology is that “the dose makes the poison.” Sixteenth-century physician Paracelsus articulated what remains the foundational principle of toxicology: sola dosis facit venenum. Water will kill you if you drink enough of it. Aspirin saves lives at 81 milligrams and causes internal bleeding at higher chronic doses. So, at what dose is glyphosate poisonous? The LD50 in rats (the dose that kills half the test animals) is around 5,600 mg/kg body weight. Table salt is roughly 3,000 mg/kg. By that classic measure, glyphosate is less acutely toxic than salt. But some people are exposed to a lot of glyphosate through their work. And among the general public, there are many questions about low-dose, cumulative exposure from multiple sources over long periods. Does glyphosate cause health problems? Cancer Correlation maps are striking, with one analysis finding that 60% of counties that spray the most glyphosate have non-Hodgkin’s lymphoma rates above the national average. But correlation alone doesn’t establish cause, which is why animal and human studies matter. In animals: Rat studies are typically what most fear is rooted in, but most people don’t know the study details on the dosage given to rats. A pooled analysis of the 13 most rigorous rat studies found evidence that very high doses, around 55,000 times greater than typical food residue exposure, can cause certain cancers. In humans: One of the strongest studies followed 55,000 herbicide users over 20 years and found no overall increased cancer risk. There was one signal: among those with the highest use, rates of acute myeloid leukemia (AML) appeared elevated. A broader meta-analysis of 18 human studies also found no overall cancer risk, though a separate meta-analysis focused specifically on non-Hodgkin lymphoma found that people with high cumulative glyphosate exposure faced a 41% higher relative risk compared to those with low or no exposure. These human studies are observational studies (randomized controlled trials would be unethical), and meta-analyses are only as reliable as the studies they pool. But the story seems consistent: at very high exposure levels, there may be some cancer risk. But that’s about as far as the science currently takes us. Emerging research: gut and reproductive health Gut: Because glyphosate targets a pathway that exists in some gut bacteria, scientists have questioned whether it could affect the microbiome. In mice, a 2023 University of Iowa study found that glyphosate altered gut bacterial composition and raised markers of intestinal inflammation. A 2024 systematic review found similar patterns: disrupted gut bacteria and problems with the mucus layer that protects the intestinal wall in mice. Whether this translates to humans is an open question. The human gut is highly variable and resistant, and we don't yet have strong studies confirming the same effects in people. Reproductive health: Animal studies have found that glyphosate-based herbicides can interfere with reproductive hormones, including disrupting egg cell development in mice and reducing the number of eggs available in sheep’s ovaries. However, the doses used in these experiments were high, so it’s not yet clear whether the same effects would occur in humans. On the human side, a 2021 pilot study led by Mount Sinai researchers tested urine samples from pregnant women across the U.S. and found glyphosate in 95% of them. The study also found a possible connection between higher glyphosate exposure during pregnancy and a subtle physical difference measured in female newborns. That said, some connections weren’t statistically reliable and this was a small study. The researchers themselves said more and larger studies are needed before drawing firm conclusions. What do regulators say about glyphosate safety? In 2015, the International Agency for Research on Cancer (IARC), part of the World Health Organization, classified glyphosate as "probably carcinogenic to humans" (Group 2A). The classification is worth taking seriously. But, there’s an important distinction: IARC classifies hazard, meaning the potential to cause harm under some conditions. It does not assess risk, which accounts for actual exposure levels and the real-world probability of harm. The U.S. EPA, the European Food Safety Authority, Health Canada, and regulatory agencies in Australia and Japan have all concluded that glyphosate is “unlikely to be carcinogenic to humans” at realistic exposure levels. They’re asking a different question: given how much of this people actually encounter, what is the probability of harm? Your actual exposure is what determines your actual risk. What does glyphosate mean for your daily life? At the grocery store: Food residues are small. The EPA’s acceptable daily intake is 1.75 mg/kg of body weight per day. To hit that threshold from oatmeal alone, a 150-pound adult would need to eat roughly 50 pounds of oats every day. But this calculation addresses only one pathway (food), and we don’t yet have robust tools to measure people’s actual total exposure. If reducing exposure matters to you, organic certification prohibits synthetic herbicides, and organic oat products generally test at lower or undetectable levels. Either way, a diet rich in whole grains, conventional or organic, is far better for your health than one that omits them out of fear of residues. On the farm: Occupational exposure is orders of magnitude higher than consumer exposure. Farmers and farm workers who mix, load, and apply glyphosate-based herbicides, especially without protective equipment, face meaningfully different risk profiles. Proper PPE isn’t optional. Integrated weed management strategies that rotate chemical modes of action are also worth taking seriously, both for health and for long-term effectiveness. If you live near a farm: Spray drift is real. Concentrations near field edges can spike during and after application, particularly on windy days. This is an area where I think public health could really step up and empower rural communities with buffer zones, rather than placing the onus on individuals. But for now, knowing your local agricultural calendar and keeping windows closed during application are the first steps. Bottom line Dewayne Johnson was exposed to glyphosate at levels most people will never encounter, and a jury decided he deserved compensation. That outcome is not evidence that the oatmeal in your pantry is dangerous. But it is a reminder that the dose, the context, and the person doing the exposing all matter enormously. Glyphosate is a chemical tool with benefits, trade-offs, and genuine open scientific questions. Learning to hold that complexity without collapsing into panic or dismissal is, honestly, one of the most useful and hardest things to do in navigating modern health science. Love, YLE Your Local Epidemiologist (YLE) is founded and operated by Dr. Katelyn Jetelina, MPH PhD—an epidemiologist, wife, and mom of two little girls. Hannah Totte, MPH, is an epidemiologist and YLE Community Manager. YLE reaches more than 425,000 people in over 132 countries with one goal: “Translate” the ever-evolving public health science so that people will be well-equipped to make evidence-based decisions. This newsletter is free to everyone, thanks to the generous support of fellow YLE community members. To support the effort, subscribe or upgrade below: Subscribe
Seahawks Survey: What will John Schneider do with pick 32?
Trade or stick and pick? What will the Seahawks do with their first-round selection?
Opinion | When faith becomes a weapon in Alabama politics
Wes Allen’s attack on John Wahl reveals a dangerous tactic—using faith as a political weapon rather than a guiding principle.
BigXthaPlug's Texas Rap Supergroup: Meet 600 Entertainment
BigXthaPlug recruited some of Texas' best rappers, like Rosama, Yung Hood, MurdaGang PB, KaineMusic, and KevanGotBandz, for his 600 Entertainment crew
Sibanye Lawyer Assassination Alarms South African Business
The assassination this week of a labor lawyer working for Sibanye Stillwater Ltd. in downtown Johannesburg has prompted a protest from South Africa’s business fraternity.
The 2026 Cohort Of Schmidt Science Fellows Is Announced
The 2026 cohort of Schmidt Science Fellows has been selected. The 32 fellows are recent PhDs who’ve been nominated as some of the world's leading early-career scientists.
Birthday boy is Bach!
Blue Hill Bach will celebrate Early Music Month with an “intimate chamber baroque” concert honoring Johann Sebastian Bach’s 341st birthday at St. Francis by the Sea Episcopal Church on Friday,
Should computer science be compulsory in Ohio schools?
Currently, twelve states in the US are phasing in requirements for students to complete a computer science course before graduating high school. Should Ohio become the 13th state? That is what a pair of bills in the Ohio Statehouse are proposing to do.
Mohamed Salah: Who is the Premier League's greatest forward?
As Mohamed Salah announces he will leave Liverpool this summer, BBC Sport asks you to rank the best forwards in Premier League history.
Moses Moody receives generous injury rehab offer from Arkansas' John Calipari
Golden State Warriors guard Moses Moody received an offer to rehab his knee injury at Arkansas by current head coach John Calipari.
Shohei Ohtani shows CY Young form in spring finale
The Sporting Tribune's Fredo Cervantes writes on Shohei Ohtani's pitching approach this upcoming season as they are on the quest to a three-peat.
Federal prosecutors to get classified House documents in Brennan probe as decision on charges against former CIA chief nears
The House Intelligence Committee voted Tuesday to give federal prosecutors classified records related to John Brennan, according to a committee spokesperson, signaling the Justice Department’s investigation into the former CIA director may be heading towards possible charges.
Mamdani uses fast food feast to bring attention to worker rights
“City Hall’s first-ever mukbang. Here we are," he said.
Scientists just discovered bees and hummingbirds are drinking alcohol
Flower nectar often contains small amounts of alcohol, meaning pollinators like hummingbirds are drinking it all day long. Despite consuming human-equivalent amounts, they show no signs of intoxication—suggesting a surprising evolutionary tolerance.
Mohamed Salah's Remarkable Career At Liverpool, Broken Down In Numbers
A by-the-numbers look at Mohamed Salah's time at Liverpool after he announced he will be leaving the club at the end of this season.
WATCH: Kushner, Witkoff, Rubio and Vance are 'in negotiations' with Iran, Trump says
Iranian parliament speaker Mohammad Bagher Qalibaf denied on Monday that Iran was negotiating with the U.S. to end the war.
Tone, Humor, and the Performative Aspect of Politics
Senators John Kennedy (R-LA) and Peter Welch (D-VT) joined C-SPAN "Ceasefire" host Dasha Burns to discuss the roles of tone and humor in politics.
Episode 68, Science for Success, Tissue testing and Potassium
By Dusty Sonnenberg, CCA, Field Leader, a project of the Ohio Soybean Council and Soybean Check-off In Episode 68, Dusty visits with soybean researchers involved in the Science for Success program. Science for Success provides timely, cutting-edge best management practices by coordinating the uni
Treating addiction
Alcohol and drug addiction can cause many harms. This Research in Context feature looks at research into the causes of addiction and new ways to treat it.
50 Cent Inks $100M Deal To Launch Entertainment Hub Featuring A Restaurant In Times Square
If you don’t hear from 50 Cent, just know he’s likely closing in on a business deal.
Christal Jordan has the latest in entertainment headlines
Iconic girl groups are going on tour, plus they're an updated on The Bachelorette news.
Why Are Jenna Bush Hager & Sheinelle Jones Absent From ‘Today’?
Find out why cohosts were missing from studio on Tuesday, March 24.
WashU Expert: Sports betting is ‘all around us, all the time’
Sports betting is “all around us, all the time,” says Washington Universisty in St. Louis’ Noah Cohan, who studies sports and fan cultures. In this Q&A, Cohan discusses the rise of online gambling, the formative impact of fantasy sports and how structural changes are reshaping the fan experience.
Football Hall of Fame to Honor St. John’s Alumnus Who Led Landmark Sports Statistics Firm
A St.
Former Cardinals players & coaches in the UFL
Keeping the dream alive
CelebrateOne secures $3.39M grant to fund for maternal health in Columbus
CelebrateOne secured a $3.39 million grant to fund 15 organizations expanding maternal health services in Franklin County.
A three-generation store in business for 100 years is expanding in CT. Owner says they, ‘nailed it.’
The father-son business team says they plan to continue to grow, as “one of the satisfactions of our job is we’re helping people.”
John Fogerty, Cyndi Lauper, more join forces to say 'Thank You, NYPD'
The 'Thank You, NYPD' concert will feature John Fogerty, Cyndi Lauper and Fat Joe, comedians Chris Distefano and Sam Morril, and more.
Florida Democrats hope in special election to flip a state legislative district that includes Mar-a-Lago
Democrats in Florida are hoping to capitalize on the party’s recent special election overperformances and come out on top Tuesday in a special state House election for a Palm Beach district that includes President Donald Trump’s Mar-a-Lago residence.
We disagreed on politics. We agreed on wine. That was enough.
At the Virginia Governor’s Cup Gala in Richmond earlier this month, a very dapper gentleman approached me and introduced himself. In his light-colored suit and bowtie, he looked very Southern in a classical sense, the sort of Virginia Gentleman you used to see south of the Rappahannock as recently as my college days. “I’m a longtime reader and fan of your writing, if not your politics,” he said. His comment was the proverbial iron fist in a velvet glove, simultaneously conveying praise and disapproval while establishing boundaries. Man, I wish we still discoursed like this instead of shouting bromides and insults to try and “own” our opponents with a funny meme and a furrowed brow. Subscribe “Well, we’ll always have wine to share together,” I said, and thanked him for his kind words. We clinked glasses, exchanged pleasantries about the delicious gold medal-winning wines being poured that evening, and went our separate ways. Our exchange reminded me that more unites us than divides us. Wine brings people together to share a meal and a few hours of joy despite our differences.1 That’s why I refer to the wine community — including readers and consumers — rather than the wine industry. Together, we are so much more than production, distribution and sales statistics. A few minutes later the evening’s awards ceremony began. Applause grew as the 12 winemakers who made the top-scoring wines for the Governor’s Case took the stage, including a loud cheer for Jonathan Wheeler of Trump Winery and his 2018 Blanc de Noir sparkling wine. All the winemakers on stage had reason to be proud, Wheeler perhaps more so. Trump Winery was the only winery to win six gold medals in the competition this year. (Wineries are limited to six entries.) Two of Wheeler’s ciders also won gold medals in a separate competition. When you cover the labels and take the sour taste of politics off your palate, the wines are pretty darn good.2 Then Gov. Abigail Spanberger, newly elected Democrat and Virginia’s first female governor, was introduced to great applause to announce which of the 12 wines had won the Governor’s Cup. She spoke for a few minutes about the importance of wine to Virginia’s economy and tourism and the international acclaim Virginia wine has received. Just two weeks earlier, she gave the Democrats’ response to Trump’s State of the Union speech, but this night wasn’t about politics. That didn’t stop several people in the crowd from speculating on the irony should she have to present the trophy to Trump Winery. In the end, Valley Road Vineyards was displayed on the screen behind Spanberger as the winning winery. Blue Bee Cidery in Richmond took top honors for that category. The crowd cheered a female governor presenting the state’s highest trophy to a female winemaker and then resumed the evening’s festivities, united by their mutual love of wine. A whiff of politics couldn’t dim the cheer of celebration and a community united by its love of wine. In Memoriam: Michel Rolland The global wine community lost a giant March 20, with the passing of Michel Rolland. He was 78. Rolland was the original “flying winemaker,” a globe-trotting consultant who helped Bordeaux regain its mojo in the 1970s and then shaped the rise of Napa Valley cult Cabernet as consultant to Simi, Harlan, Newton, Screaming Eagle, Araujo, Dalle Valle and other wineries. He was instrumental in Argentina’s rise to prominence and even had his own winery, Clos de los Siete, in a partnership with other wine families. Rolland’s career arc paralleled that of Robert Parker, the world’s most influential critic. Parker championed many of the wines Rolland consulted on, helping build his reputation and demand for his services. It also made him a target for Parker’s critics. As W. Blake Gray wrote on Wine-Searcher in his excellent tribute to Rolland: Rolland created the type of wines Parker loved: rich body, plenty of fruit, soft tannins. He sometimes faced the accusation of creating a generic international style of red wine, where the great wines he made in Argentina were indistinguishable from the great wines he made in France. Rolland chafed at that critique, as did many of his fans. He was credited with championing green harvesting and leaf pulling, as well as careful selection of grapes in the winery, practices we nearly universally think of today for high-quality winemaking. “Michel was an incredible innovator who changed how wine was made and how grapes were grown,” Napa Valley winemaker Aaron Pott wrote on Facebook. “His work has transformed the wine trade. He created new ways of looking at wine, tasting wine, evaluating ripeness and quality. … This was not just a man with a ‘style’ that he imposed on vineyards but a man that understood how to make great wine from great sites.” Rolland started his consulting company in 1973 in Libourne, in Bordeaux, with his wife, Dany. Both had graduated the year before from Bordeaux’s Institute d’Oenologie. The couple sold their majority share in the business in 2020, according to Wine Spectator. Over his career, Rolland reportedly worked with more than 100 wineries in 20 countries. He even made it to Virginia, where he consulted for Kluge Estate in the mid-2000s. (Kluge Estate is now Trump Winery.) Reader feedback, please! Last week, I did my first WineLine Live! with Dr. Laura Catena of Catena Zapata winery in Argentina. We enjoyed a fascinating discussion about her efforts to preserve the genetic heritage of old vineyards in Mendoza. I conceived of WineLine Live! for paid subscribers, as a thank you for your financial support. And while only a few people joined live, the video now has more views than I have paid subscribers, so I guess that’s pretty good. Even so, I’m considering opening future installments to anyone on Substack to reach a broader audience. So my questions to you: Should these be public? And what format do you prefer? Live gives a chat feature with the potential for viewers to interact with me and the guest, while a video post would just be that. Another alternative is a podcast, which would just be audio, without video of my chins. Please let me know in the comments. Leave a comment In the Glass A few wines I’ve enjoyed recently: Bonny Doon Vineyard Take Me to Your Liter, Le Cigare Volant, Red Wine of the Earth. 2023, Central Coast, CA. Blend of Grenache, Syrah Cinsaut and Petite Sirah. Delightful wine with expressive red fruit flavors, casual drinking. Doon lovers of a certain age will remember Randall Grahm’s Big House Red; this is more in that style than his original Le Cigare Volant, modeled after Chateauneuf du Pape. The liter bottle makes it an even better value. I see this online at about $15. Great value. Albert Bichot Bourgogne Pinot Noir Origines 2023. 13% - Textbook pinot noir and an excellent, affordable entry (regional) Burgundy. Wine Enthusiast Top 100 Wines of 2025. $24 at Total Wine & More. Loma Larga Pinot Noir 2021 “Coastal Cool Climate Wine”, Valle de Casablanca, Chile. An older sample, showing beautifully. Spicy and fruit forward. I’m seeing widely varied pricing online, from $18-$32. At the lower end, it’s a terrific value. 13.5% Dr. Loosen Riesling Dry 2016, Mosel, Germany. Found this “in the stack.” And it stacked up well, shedding some of its youthful acidity for opulent Riesling character, including a hint of the mineral oil older Riesling often features. A great value, as I’m seeing it as low as $14 online. 12% abv. Red Tail Ridge Blau Franc Blend 2024, Sans Oak, Finger Lakes. 13.4% abv. The name is a neat portmanteau of Blaufrankisch and Cabernet Franc, thus Blau Franc. The blend is 50-50, no oak involved. The Blau dominates on the palate, with the spicy caraway seed (think New York deli rye bread). The Franc adds body. The result is juicy, energetic and joyful. Sokol Blosser Estate Rosé of Pinot Noir 2025, Dundee Hills, Willamette Valley, Oregon. This first rosé of 2025 was a welcome respite to our cold, snowy winter here in the Mid-Atlantic. Oh man, I needed this! Bright and energetic, exuberant even, it perks up the mood and goes down fast. 13%. Certified B Corp. Ingredient and nutrition labeling, and in a modest way that doesn’t occupy a lot of label space. (Since it’s not required, presumably there are no minimum font size requirements.) More wineries should follow this example. Dave McIntyre's WineLine is a reader-supported publication. To receive new posts and support my work, consider becoming a free or paid subscriber. Subscribe Thanks for reading Dave McIntyre's WineLine! This post is public so feel free to share it. Share 1 Some restraint may be required. 2 Especially the bubblies.
Entertainment and more in the Mid-Ohio Valley
PARKERSBURG – The Artsbridge calendar for this week: TODAY * Geppetto Woodcarver’s Wood Quilt display, 9 a.m. to 4 p.m., WesBanco, Market Street, Parkersburg * Art is Life/Life is Art, ages 55-plus,10:30 a.m. to 12:30 p.m., Parkersburg Art Center * Butterfly Photo Holder, ages 13-plus,11 a.m. to noon, Marietta Public Library * Hygge Club, adults, […]
Revolutionary Women: Lady Johnson, Angelica Schuyler and the Politics of Loyalty
State and territory commissions and other partners are hosting events across the nation to commemorate America's 250 anniversary in 2026.
Utah Sen. John Curtis helps lead push to ban sports betting contracts on prediction markets
Utah Sen. John Curtis and California Sen. Adam Schiff are leading a push to make clear that sports prediction markets are indeed gambling.
Trump puts Republicans in a bind on the DHS shutdown: From the Politics Desk
Plus, the Supreme Court hears a case with big midterm implications.
Top business leader demands end to stalemate over City Council's pick for zoning chair
Chicagoland Chamber of Commerce President Jack Lavin said more than 40 development projects have been stalled by City Council's failure to agree on new permanent chair for the powerful Zoning Committee. He wants Mayor Brandon Johnson to forge a compromise to break the stalemate.
The live-action 'Moana' trailer debuts Dwayne Johnson as Maui — and fans can't stop talking about his hair
The remake of the 2016 animated film hits theaters July 10.
Brian Doherty, 57, Dies; Chronicled Libertarians and Other Outsiders
Fascinated by the fringes, he wrote a definitive history of libertarianism and books about underground comics and the Burning Man festival.
LIVE AT 3:30 P.M.: Ewing to announce entertainment for Omaha’s Memorial Park concert
On Monday, Omaha Mayor John Ewing Jr. is expected to announce details for the Memorial Park concert.
From The Sports Desk: Cinderella’s rough weekend
Iowa knocked off the defending champions, Florida, in a rare upset over the weekend in the NCAA tournament.
Exit polls suggest Italy's Meloni has narrowly lost justice referendum vote
Exit polls on Monday suggested Italian Prime Minister Giorgia Meloni had narrowly lost a referendum on her flagship reform of the judicial system, dealing a potential blow to the ruling coalition ahead of next year's general election.
Apple Reportedly Preparing 'Biggest Set of iPhone Revamps' Ever
Apple is working on "the biggest set of iPhone revamps in the product's history," according to the latest word from Bloomberg's Mark Gurman. Specifically, he is referring to the long-rumored foldable iPhone, as well as an ambitious 20th-anniversary iPhone with a truly "edge-to-edge" design.
Prisco's 2026 NFL mock draft 1.0: Four of top five picks on defensive side, Browns select QB
Teams at top of the draft opt for pass rush over offense.
Blue Jays extend manager John Schneider, GM Ross Atkins following World Series appearance
The Blue Jays are locking up two architects of the team's World Series run.
10 Surprising Perimenopause Symptoms That Are More Common Than Hot Flashes, According to New Research
Think perimenopause is just about hot flashes? Check out these very common other menopause symptoms.
Benjamin Logan students shine at Regional Science Day competition
Benjamin Logan students had a strong showing at the Ohio Academy of Science Regional Science Day at Ohio Northern University. Competing against top students from […]
Ohio lawmaker proposes election board changes after Delaware County dispute
Dispute at the Delaware County Board of Elections prompted a state lawmaker to propose changes to how county election boards work.
How to beat Gigantamax Pikachu: Best Counters & Guide
Gigantamax Pikachu is a Tier 6 Max Battle in Pokémon GO. It will cost 800 Max Particles to participate in this Max Battle, which will only be consumed if you defeat Pikachu successfully. Gigantamax Pikachu can be shiny from Max Battles. Being an type, it is only weak to type moves. Pikachu can be caught […]
Data centers under scrutiny by California lawmakers as fears rise about health and energy impacts
Due to health and energy concerns, the California Legislature is considering bills to prohibit data centers from being exempted from the state's stringent environmental law and impose new tariffs on new major energy users that strain power supplies.
Samsung adds native AirDrop support to Galaxy S26 devices
Share files with Apple-using friends
Exclusive | Lawmakers to Introduce Bipartisan Bill Banning Sports Bets on Prediction Markets
A bipartisan pair of U.S. senators are introducing legislation to prohibit CFTC-regulated entities from listing contracts related to sporting events.
Ohio State vs Notre Dame predictions, picks, odds for NCAA Tournament Second Round
Our March Madness experts pick the winner for No. 3 Ohio State vs No. 6 Notre Dame in the 2026 women's NCAA Tournament on March 23
Incredible offer signals Liverpool are all-in on Rio Ngumoha
An incredible offer of a player signals a real intent from Liverpool to go all-in on teenager Rio Ngumoha.Are Liverpool about to go all-in on Rio Ngumoha? They’ve been reluctant to do so this season...
Winners and losers from first weekend of the NCAA tournament feature John Calipari, Darryn Peterson, Big Ten and blue bloods
Kansas coach Bill Self non-committal if he'll return next year due to health concerns
Hall of Fame Kansas basketball coach Bill Self said after a crushing loss to St. John's that he hasn't decided if he'll be back next season or retire.
Kansas squanders its best player as Darryn Peterson's college career with second-round loss to St. John's
The Peterson era in Lawrence is likely over.
Bill Self says coaching future at Kansas to be determined
Longtime Kansas coach Bill Self said after Sunday's season-ending loss to St. John's that he has not yet made a decision about his coaching future, later adding that any decision will be based solely on his health.
Kansas coach Bill Self unsure about future after buzzer-beater loss to St. John's: 'I haven't decided'
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Your Thymus and Your Healthspan
Our thymus gland plays a central role in the development or our immune system, specifically for supporting T cell development (how these cells got their name, maturation and differentiation in the thymus) and discriminating between self and foreign, non-self antigen proteins with production of dendritic cells. As we age, our thymus gland shrinks—the process known as involution—with progressive change from spongy to fatty tissue, with loss of functionality. But this process, with respect to timeline and extent, markedly varies from one person to the next. And to make things even more complicated, our thymus gland anatomy and precise location in the chest also is highly variable. So the famous Frank Netter diagrams from the 1960s (such as at left below) don’t capture the remarkable heterogeneity that a random set of 12 chest CT scans (below at right). What I consider as 2 landmark papers in Nature this week (here and here) used AI to quantify health of the thymus in 2 large cohorts, and then correlate the metric to a broad array of health outcomes. In this edition of Ground Truths, I’m going to cover three questions: (1) How was thymus health determined by AI?; (2) How is thymus health linked to key clinical outcomes? and (3) Are there ways we can promote a healthy (aka rejuvenate) thymus gland in our later years? Subscribe 1. How was thymus health determined by AI? This was accomplished by extensive work developing and validating an AI pipeline for 2 stages, the first for localization and segmentation of the thymus bed, and the second to quantify a digital marker, termed the thymic health score. There’s a lot to this algorithmic development, so I won’t go into all the details, but just provide a rudimentary outline of what was done. The 1st stage used supervised learning with 2 radiologists reviewing 2,461 chest CT scans. That work trained a 3D U-Net model to automatically identify the thymic bed’s 3D cropped region using center of mass coordinates, which reached 99.8% accuracy. The 2nd stage used a foundation model that was pre-trained with SwAV (which stands for Swapping Assignment between multiple Views), a self-supervised model, that generated a high-dimensional thymus representation of 4,096 features. That compares to the radiology reductionist and subjective scoring of 0 to 3 where 0 means the thymus is fully degenerated and fatty, and 3 is considered dense, intact glandular soft tissue. Notably, the self-supervised learning (SSL) performance was superior to supervised (AUC ~0.75 vs 0.55, respectively) reflecting the shallowness of the 0-3 classifier vs SSL’s holistic, self-taught AI. The thymic health score ranged from 0 to 100, with the highest number indexed to fully preserved thymic health. The algorithmic work extended to explainability with both Shapely value distribution, meaning the model was holistic not relying on any “magic” pixel, and occlusion sensitivity, demonstrating the model’s performance was not affected by ribs, sternum, lung tissue, but rather focused on the thymic bed directly. Below are a few saliency maps from the occlusion sensitivity that indicate the thymic bed focus, not affected by neighboring structures, using the jet color scale. Now the AI was ready for processing ~25,000 CT scans, each over 30 MB files, from the 2 large participant cohorts to provide a thymic health score, it did so in less than 14 hours, which is less than 2 seconds per scan! Share 2. How is thymus health linked to key clinical outcomes? The two cohorts were the National Lung Screening Trial, NLST (N=25,031) and the Framingham Heart Study, FHS (N=2,581) each with baseline demographics and long term follow up of >12 years for health outcomes. From the NSLT, you can see below that increased age and body-mass index were correlated to reduced thymic health. And, overall, men had reduced thymic health scores compared with women. There are a lot of graphs in the paper for outcomes, for both the NLST and FHS cohorts. To simplify the major outcomes, below is a composite Figure with striking reduction of all-cause mortality and for the different causes of death. The results were consistent between the 2 cohorts. For example, the cardiovascular mortality hazard ratio average was 0.57 in NLST and 0.38 in FHS (weighted to be 0.53 for the aggregate). The reduction of mortality also extended to digestive diseases and pulmonary disease (data not shown below). Lung cancer incidence was reduced by 36% for high vs low thymic health (Figure below, with a panel -incidence and b panel-mortality, adjusted for age, sex, BMI, smoking status). Notably, there was a smoker’s paradox: lower incidence and improved survival for lung cancer in smokers who had a high thymus health score. Smoking was associated with lower thymic scores whereas alcohol was not. Higher thymic health was linked to higher HDL cholesterol, lower triglycerides, lower fasting blood glucose, and lower systolic and diastolic blood pressure. Inflammation biomarkers, such as C-reactive protein and interleukin-6, were elevated in the people with lower thymic health scores. In their second paper, the same team looked at the relationship between thymic score and outcomes for 3,476 patients receiving cancer immunotherapy. The non-small cell lung cancer progression-free survival was reduced in patients with low thymic health score. A parallel relationship for survival was seen for other types of cancer including melanoma, breast, and kidney with a 44% lower risk among high thymic scores (Figure). A similar pattern was seen with different immune checkpoint inhibitors. The thymus health score outperformed programmed death ligand-1 (PD-L1)and tumor mutation burden (TMB) assay of the tumor and was an independent prognostic marker of progression-free survival. In this dataset, a direct connect with thymus score and adaptive immune function was noted with a correlation before cancer treatment for both T-cell diversity and thymus T-cell production (a metric known as T cell receptor excision circles). Thymus Removal Study There is a highly relevant citation about thymus function before moving onto ways to rejuvenate it. In 2023, a very important study of thymus removal during cardiothoracic surgery was published, with 1146 patients undergoing thymus removal vs 1146 matched controls (mean age 55 years). The adverse outcomes for thymus removal were striking, with a 2.9 higher risk of all-cause mortality and doubling of cancer incidence, 1.5 fold increase in cancer mortality, and 1.5-fold increase in autoimmune diseases. The immune function showed marked compromise after thymus removal, as reflected by CD4+ and CD8+ T cells (Figure below) Share Ground Truths 3. Are there ways we can promote a healthy (aka rejuvenate) thymus gland in our later years? In recent months we’ve learned a lot about the process of thymus involution and the pathways by which this may be modulated. Thymus involution is primarily due to loss to thymus epithelial cells (TECs) and there are 2 subtypes with different functions: the cortical, responsible for positive selection of T cells, and the medullary, for negative selection. When adipose tissue infiltrates the thymus, thymic adipocytes are pro-inflammatory, knocking out T-cell output. Likewise, systemic inflammation, or “inflammaging,” from smoking, obesity, and chronic stress promote thymic adipocytes. Now, from preclinical studies, we know about key pathways that account for these processes. Historically, back in 2014, FOXN1 was recognized as a single master transcription factor essential for TEC function, with studies in mice with forced FOXN1 upregulation leading to thymus regeneration. That laid the foundation for potential regrowth of quiescent thymus cells. It took awhile to find pathways to accomplish this goal and to even refute its role as the master regulator. The Liver-Thymus Axis Feng Zhang and his team recently showed that injection of an mRNA vaccine to the liver encoding DLL1, IL-7 and FLT3-L in combination, factors known to support thymopoiesis (Figure), successfully enhanced immune function in aged mice. However, the effect was transient. The FGF21 Story Two reports in 2025 addressed the thymus gland’s production of FGF21, a growth factor (fibroblast growth factor 21) and its control of thymus involution. This growth factor is also produced by the liver, but it doesn’t have impact on the thymus in aged rodent models. In contrast, The liver’s hepatocyte growth factor (HGF) has been shown to reverse senescent TEC structural changes. Growth hormone stimulates production of insulin growth factor-1 (IGF-1) in the liver and the thymus. Two small studies in human participants (TRIIM, for Thymus Regeneration, Immunorestoration, and Insulin Mitigation) of 6 and 50 people, respectively, treated with combined human growth hormone, metformin and DHEA, suggested the potential of slowing epigenetic aging and improving thymus mass and function. But the combination of drugs, small sample, and lack of controls make conclusions murky. Increased thymus FGF21 led to increased CD8 T cells in old mice and extended healthspan and improved physical performance. Building on the previous FOXN1 data, ablation of β-klotho, the obligatory co-receptor for FOXN1, accelerated thymic aging. The benefit to FGF21 was confirmed in a companion paper using an FGF21 knock-in mouse model showing thymus enlargement and increased TECs throughout the lifespan. (schematic Figure below). The accompanying editorial for these 2 papers speculated: “The proposed link between age-associated thymus involution and organismal aging is intriguing, and suggests we might seek to achieve systemic rejuvenation by counteracting thymic involution.” Other Factors Lessons from the Axolotl (Mexican Salamander) In an elegant set of experiments of the axolotl (Figure), known for its complete thymus regeneration after total surgical removal, mediators were identified. Surprisingly FOXN1 was dispensable. But midkine, a growth factor, appeared to be the driver, the initiator of thymus cell growth, survival, and repair. Other components that contributed were Postn+ (periostin-expressing mesenchymal niches) and Ccl19, a chemokine protein from the bloodstream. RANK and RANKL RANK (receptor activator of nuclear factor κB its ligand (RANKL) have been considered key regulators of medullary TECs. In a study of both aged mice and human thymus cell cultures, their key role was confirmed, with multiple benefits of resorting TEC function, recruitment of progenitor cells, and T cell development. Subscribe Summing Up This body of work strongly supports the health of the thymus gland as a critical regulator of human healthspan, not just a correlate or link. The new landmark studies are reinforced by the regenerative biology experimental models that have shown, via an array of mediators, that healthspan of aged mice is at least in part dependent on thymus gland function and its critical role for maintaining adaptive immunity. It sure seems that we’d be better off having an immune reservoir of naive T cells instead of a profile in older adults of exhausted, low quality, memory T cells, with a senescent phenotype. It is striking that we ignored the importance of the thymus gland for many decades. A wake-up call was the results of the thymectomy matched control study reviewed here, with the opposite of high thymic health score improved health outcomes. The convergence of AI and healthspan here is notable. The exceptional and laborious work for developing and validating (no less explaining) the AI to quantify thymus health set the foundation for probing the connect the major health outcomes in two cohorts with extensive follow-up. We’ve never had a way to meaningfully quantify the thymus gland before, so this represents important leverage of supervised, self-supervised, and transformer models. The study wouldn’t have been possible without AI. And it begs the question as to whether there are ways we can maintain our thymus at a high health score. But it’s not so simple to rejuvenate our thymus. There are multiple risks including the induction of autoimmunity, increasing the risk of cancer, and inducing a pro-inflammatory state. For example, factors that increase TEC proliferation could compromise the medulllary negative selection process and leak out auto-reactive (self-attacking) T cells. Thymic cells could be induced to proliferate, but we know, for example, that growth hormone and IGF-1 are associated with an increase risk of cancer. If thymus rejuvenation doesn’t clear out the accumulated senescent cells in older adults, then inflammation within the gland could block the production of TECs. Keeping these risks in mind, we now have identified many ways to keep our thymus healthy as we age that undoubtedly will be tested in clinical trials going forward. Ultimately, the benefit-to-risk tradeoffs will be defined. In the meantime, we have desperately needed an immunome. As I’ve stressed in multiple prior Ground Truths, we have no test in the clinic to assess a patient’s immune status! It was very encouraging for me to get an email from Hugo Aerts, the senior author of the landmark papers in the days after they were published: “I also wanted to say that your Substack on “Why We Need an Immunome” was inspiring for this work. We found it a very compelling perspective and greatly enjoyed reading it.” Just having an assessment of a person’s immune status via a chest CT scan, with millions of these performed per year, might help in guiding the right immunotherapy for cancer (e.g. more intensive, combinations for those with low thymic health scores) and help define people who are increased risk for age-related diseases of cancer, cardiovascular, and neurodegenerative. The main theme of Super Agers is that we now have many layers of data (genetics, proteins, biomarkers, organ clocks that can be integrated via multimodal AI) for us to define a person’s specific risk decades before one of these age-related diseases leads to symptoms, enabling prevention. From the new studies this week, we can add thymus health score as yet another way to understand a person’s risk, a window into their adaptive immune system and healthspan. And perhaps someday we will be able to safely rejuvenate the thymus, or maintain its health through one’s life, and use the thymus health score to monitor. NB: I wrote this post (No A.I.) A Quick Poll Loading... ********************************************************************* Thanks to Ground Truths subscribers (now > 200,000) from every US state and 212 countries. Your subscription to these free essays and podcasts makes my work in putting them together worthwhile. Please join! If you found this interesting PLEASE share it! Share Ground Truths Paid subscriptions are voluntary and all proceeds from them go to support Scripps Research. They do allow for posting comments and questions, which I do my best to respond to. Please don’t hesitate to post comments and give me feedback. Let me know topics that you would like to see covered. Leave a comment Many thanks to those who have contributed—they have greatly helped fund our summer internship programs for the past two years. It enabled us to accept and support 47 summer interns in 2025! We aim to accept even more of the several thousand who will apply for summer 2026.
Politics Now: March 22, 2026
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