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Unc’s Pizza opens for business in downtown Detroit
Detroit’s Capitol Park neighborhood in the city’s downtown has a new local spot for Detroit-style pizza.
Wix launches Symphony, a new standalone multi-agent system built for business operations
Wix launches Symphony, a new standalone multi-agent system built for business operations - SiliconANGLE
Politics & Power: Big opportunities, real risks, ethics & oversight as AI reshapes the legal industry
AI can make legal work faster, cheaper, and more accessible, but it doesn't come without risk. The organizations that come out ahead won't just be the ones that adopt the best tools. They'll be the ones that pair those tools with clear oversight, honest communication with clients, and a genuine commitment to getting it right.
2026 Fall Preview: Willow Springs Volleyball
Share on Facebook Share on Twitter By Michael Cignoli (For OzarksSportsZone.com) When Dawn Gastineau’s volleyball career ended, she never considered the possibility that life might one day lead her back to the sidelines. But that’s exactly where
UNCW Athletics, Novant Health and EmergeOrtho Forge Landmark Partnership to Enhance Student-Athlete Health and Wellness
WILMINGTON, N.C. – UNCW Athletics announced that Novant Health and EmergeOrtho are proud partners of the Seahawks, beginning in the 2026-27 academic year. This multi-year agreement shows UNCW's dedication to providing a top-tier student-athlete experience through the largest transformational investment in UNCW Athletics history.
Ari Emanuel's Mari Acquires ATG Entertainment
Ari Emanuel's events company Mari, founded in 2025, has acquired ATG Entertainment. The West End and Broadway venue owner and ticketing company was acquired for £4.5B ($6B).
Top Obama ally reveals which far-left candidate needs to lose to help progressives win
David Axelrod calls Francesca Hong a "font of zany liberal, faculty lounge exotica" and says her Wisconsin primary loss would help Abdul El-Sayed.
10 classic car models from the '80s are now worth a small fortune
From high-performance icons to everyday commuters, these '80s cars have evolved into valuable collector favorites.
This was just voted the best sports venue in Metro Detroit
What is the best sports venue in Metro Detroit? The votes are in, and we have a winner!
Democratic rebellion against older politicians reaches new battleground
Former Hartford Mayor Luke Bronin, 47, is challenging Rep. John Larson, who is 78 and running for his fifteenth term representing Connecticut's first district.
Phillies bring road win streak into matchup with the Cardinals
The Philadelphia Phillies visit the St. Louis Cardinals aiming to extend a three-game road winning streak
Deacon Sports Xtra: Demon Deacons Gain Meaningful Experience at 2026 ACC Unity Tou
A group of five partook in the conference's annual event, held in Washington D.C. this summer.
Congo says 2,000 people have died in its Ebola outbreak, the fastest growing on record
Congo's Ebola outbreak has recorded at least 2,000 deaths among confirmed cases, the fastest growing on record.
Congo says 2,000 people have died in its Ebola outbreak, the fastest growing on record
Congo's Ebola outbreak has recorded at least 2,000 deaths among confirmed cases, the fastest growing on record.
RTC’s Game Day Express returns for 2026-27 sports season
Get the full list of casino pickup locations and departure schedules as the Regional Transportation Commission kicks off its direct stadium transit service.
Phillies survive extremely shorthanded bullpen for win over Cards
The Phillies held on to win 6-5 in the series opener in St. Louis.
As Trump Media scraps some businesses, it's doubling down on Truth Social and the president
The president's social media company is going back to its roots.
As Trump Media scraps some businesses, it's doubling down on Truth Social and the president
The president's social media company is going back to its roots.
Animal Advocate: Man grieves after dog’s death at grooming business remains a mystery in Miami-Dade
Brandon Rivero said he found his beloved 5-year-old Chinese Shar Pei dog named Ringo dead after trusting him to a groomer in Miami-Dade County.
Cook Political Report shifts Max Miller seat to toss-up
The nonpartisan Cook Political Report shifted Rep. Max Miller’s (R-Ohio) seat from “Likely Republican” to “Toss Up” on Monday, underscoring the growing political fallout from allegations of domesti…
Walking is one of the best exercises for heart health — but experts say strength training matters too
Heart health is closely tied to everyday energy and resilience. A trainer explains what actually makes the biggest difference — and where most people get it wrong.
Health Brief: Is Minnesota ready for Medicare-for-all?
Plus: Trump’s new effort to upend childhood vaccines
Jury selection begins in Tupac's murder case. Why did it take 30 years to get here?
The long-awaited trial over Tupac Shakur's 1996 killing begins on Monday, with prosecutors relying heavily on Duane "Keffe D" Davis's own statements.
Pied-à-terre tax rollout blocked temporarily by Staten Island judge
The next hearing is set for Aug. 31.
Pied-à-terre tax rollout blocked temporarily by Staten Island judge
The next hearing is set for Aug. 31.
Judge pauses pied-à-terre tax rollout after homeowners allege botched launch
Staten Island Judge Wayne Ozzi heard arguments on a motion for a temporary restraining order to block the rollout of the pied-à-terre tax.
Todd Blanche sworn in as attorney general after bruising confirmation battle
With the confirmation fight behind him, Blanche now faces the challenge of having to navigate the demands of a president who has made no secret his desire to use the law enforcement agency to target his political foes.
Saber's newest game trailer takes a shot at Gearbox's CEO, if you look closely
The first hint that something might be up with the recent debut trailer for Saber Interactive’s Rideshare Stimulator is an unusual choice of words—aside from that second one in the game’s title. “Don’t take your passengers too seriously,” the trailer’s narrator says, as he describes this upcoming game. It a car game about the gig work of driving eccentric people to their destinations, a riff on Crazy Taxi. And then, he says: “When I think I’ve met the randiest of passengers, someone even stranger gets in.” “Randiest”? That suggests “randy,” which usually means having strong sexual desire. Yet none of the oddball backseat occupants featured in the trailer seem particularly lustful. One is an old man who considers his grandson a failure, another shares the theory that birds might control traffic lights, another says he’s banned from an aquarium. A little later, there’s a license plate, shown 63 seconds into the trailer, on the front of an SUV: USB DRV It’s a Texas plate. The symbol between those letters is a cog wheel. If you know, you know. That’s a reference to Texas-based Borderlands game development studio Gearbox Software (their logo features a cog wheel). More specifically, it’s a reference to Gearbox’s CEO Randy Pitchford, who in 2018 found himself explaining the nature of video he’d saved on a USB drive that was found at a Medieval Times restaurant before being returned to the studio: “It was ‘barely legal’ porn. This girl’s handle was ‘Only 18.’” The “girl” in the video had committed a solo sex act that Pitchford, an avid practitioner of magic, found remarkable. “I realized, this is not a sex worker…This is a fucking magician.” Back then, the USB drive was central to competing lawsuits against Gearbox by the studio’s former lawyer and by Gearbox against him. A settlement in late 2019 “exonerated” Pitchford, per the Hollywood Reporter. The USB story has resurfaced at times, now in a trailer from a company that not long ago was corporate brethren with Gearbox. Saber vs. Gearbox The head of Saber told Game File that the reference is payback. “The dig is because Randy took shots at Embracer in Borderlands 4,” Saber CEO Matt Karch told me when I asked him about the license plate. “Without Embracer, Randy is performing magic tricks at birthday parties for a living.” Having interviewed Karch during a cross-country flight in late 2024, I can confirm that Karch was unimpressed with Pitchford during their time both working in the Embracer group. I’d approached him not out of surprise that there was animosity but that it was manifesting publicly now. Gearbox was founded in 1999, worked on a port of Halo early on, and developed hit series such as the loot-based sci-fi shooter Borderlands before it was purchased by The Embracer Group in early 2021 for $363 million (with a possible earn-out of over $1 billion, if certain targets were hit by 2027). Saber was founded in 2001, worked on a remaster of Halo early on, had a big hit with zombie shooter World War Z and was purchased by Embracer in early 2020 for $150 million, with a potential earn-out of up to $375 million. For a few years, the Embracer group was a voracious acquirer of game studios. Then, as investment dried up, it choked. In March 2024, Embracer sold Saber to an investment company controlled by Saber CEO Matt Karch, and it sold Gearbox in an all-stock deal to long-time Borderlands publisher Take Two Interactive. Other studios were shut down. Hundreds of developers were laid off. Gearbox didn’t say much about their Embracer experience, nothing too direct, at least. In the summer 2024, Pitchford told reporter and occasional Game File contributor Nicole Carpenter that Borderlands 4’s story was in some way thematically connected to Gearbox’s experience at Embracer: “There’s this cultural and emotional shift in me, personally, and at the studio. What does it mean to trade some autonomy for organization?” When Borderlands 4 came out, there was something stranger: the matter of “Embracer’s Bluff,” a location in the game featuring an AI-powered toilet and a large trash dump, according to a detailed Kotaku account of the place. Gearbox never commented on it; Take Two never got back to me about it when I asked them last year. By contrast, since Saber exited Embracer, Karch has been one of Embracer’s biggest defenders, casting their management as well-meaning and supportive despite the layoffs and studio closures that resulted from their excessive expansion. Like others, Saber’s Karch saw Embracer’s as a shot. With Rideshare Stimulator’s trailer, he’s returned fire. “It’s amazing to me how fast people forget those who went above and beyond for them,” Karch told Game File. A rep for Gearbox did not comment by press time. Game File is a reader-supported publication. Your backing makes my reporting—including any coverage of trailer-based beefs—possible. Good news! I’m currently running Game File’s first big sale of 2026. You can get a one-year subscription for 23% off. Click here to take advantage of the limited-time offer. And thank you for your support! Item 2: In brief… 🚫 Wal-Mart has laid off the staff of Restart, a games media outlet launched in 2024, Aftermath reports. 🟥 A GTA VI preview is on the way, at last, via an “extended look” that will premiere, unusually, on Netflix at 3pm ET on August 27, then officially go live elsewhere six hours later. Last week, Game File noted that Take Two label Rockstar Games is overdue for showing off GTA VI, based on the timing of the initial hands-off previews of GTA V and Red Dead Redemption 2. During a call with investors, Take Two CEO Strauss Zelnick said pre-orders for GTA VI were “unprecedented and astonishing,” but added the company can’t predict how many of those pre-orders represent bonus sales vs. sales that otherwise would have been made at launch. During the same call, Zelnick was noticeably bullish on the future of playing games over streaming cloud connections (predicting wider adoption in three or so years). He sounded unbothered by Sony’s plans to stop making discs for new games (he said the business is 90% digital already and predicted that there could still be limited edition physical editions of games “in the same way there’s still vinyl in the recorded music business.”) 👀 Take Two wrote off $43 million in their spring quarter after deciding “not to proceed with further development of an unannounced title in its pipeline from a third-party developer.” 🤔 Some rare age-demographics from a big publisher: Capcom recently told investors that “users in their 20s account for approximately half of the users of both Pragamata and Resident Evil Requiem.” Item 3: The week ahead Tuesday, August 11 Game releases: The Elder Scrolls IV: Oblivion Remastered (Switch 2; already out for PC, PS5, Xbox) continues the Bethesda strategy of putting Elder Scrolls games on everything; Royalty Free-For-All is a Smash Bros.-style fighting game featuring public domain characters such as Mother Goose brawling with Oliver Twist in a stage based on the original Little Shop of Horrors movie. Wednesday, August 12 Game release: Pro Jank Footy (PC, console) is an arcade-style Australian Rules Football game with increasingly ridiculous rules, the more you play (I enjoyed the Steam demo) Thursday, August 13 Game release: Super Mario Sunshine (Switch 2, originally released in 2002 on the GameCube) is released for Switch 2’s Nintendo Switch Online service. This game is the black sheep of 3D Mario games. It’s the successor to the breakthrough Super Mario 64 and the rare Mario game built around a single (vacation resort) theme. Mario’s got a water-spraying backpack, a Yoshi pal and a lot of blue coins to collect.
5 SWLA residents accused of stealing equipment from closed business near Crowley
Five Southwest Louisiana residents are among several people accused of stealing from a vacant building off I-10 near Crowley.
WATCH: Trump signs executive order on childhood vaccine recommendations
The order recommends separating the MMR vaccine into three different shots administered in separate visits, and directs the nation's health department to improve vaccine research, says a White House fact sheet.
Hunter Biden tells Tucker Carlson that Trump poses an ‘existential threat’
Biden has made a point of talking to conservative media figures in recent months.
Woman’s Perinatal Mental Health Unit leads a new approach to maternal mental health
The Perinatal Mental Health Unit at Woman’s Hospital is being honored with a Community Impact Award for its work establishing mental health care for pregnant and postpartum women. The award is part of Business Report’s inaugural Excellence in Healthcare Awards. The hospital opened the Perinatal Mental Health Unit, Louisiana’s first inpatient psychiatric unit dedicated exclusively […]
Jen Hamilton reflects on her estranged husband's alleged 'betrayal' with 'a grandma': Meet the labor nurse who's going viral
Since publicizing their split, Jen has continued speaking about it candidly on social media.
Collin Jones - Assistant Director of Sports Information & Media Relations
ERIE, Pa. – Gannon University Director of Athletics Meghan Morphy has announced the hiring of Collin
OpenAI announces premium business pricing, as it seeks to increase revenue ahead of IPO
OpenAI announced premium business pricing, as it preps for IPO.
Trump nominates loyalist to office that would oversee Reflecting Pool review
Dennis Kirk, a Project 2025 author who had worked for then-Director of National Intelligence Tulsi Gabbard, may now run Interior’s inspector general office.
Congo's fast-moving Ebola outbreak started month before it was declared, WHO says
The World Health Organization says the fastest-growing Ebola outbreak started in February, months before it was officially declared in May.
Chad reacts to his interview with Dean Phillips, talks about Iran, and laments the worst of politics today
Chad reacts to his interview with Dean Phillips, talks about the quagmire of Iran, and laments the worst of what we see in politics today. | 830 WCCO
Enterprise connectivity boosts AI performance and security
AI and cloud demands reshape enterprise connectivity. Optimum Business provides scalable solutions for secure and efficient network architecture.
Health alert issued for Lake Howell after toxic algae discovery
Urgent health alert for Lake Howell: Blue-green algae toxins detected. Avoid contact and protect pets.
Minnesota Cannabis Businesses Grapple With Growing Pains
Minnesota's hyper-regulated cannabis industry is starting to bear fruit—er, flower. But uncertainties remain about whether operators have sufficient breathing room to build viable businesses.
Ocasio-Cortez says she's freezing her eggs as she considers her political career
The 36-year-old Ocasio-Cortez announced her decision on social media before explaining in an ABC "This Week" interview Sunday she has not ruled out running for president or for U.S. Senate.
Aliens: Fireteam Elite on Nintendo Switch Shut Down With No Refunds, as Owners Become The Latest Victims of Gaming's Increasingly Digital Future
Aliens: Fireteam Elite has had its cloud servers shut down, leaving Nintendo Switch owners unable to play the game without any form of refund.
How sports diplomacy is changing how nations connect
Sports diplomacy can strengthen alliances, reduce tension between potential enemies and turn the world’s attention toward regions too frequently ignored.
Lifeways getting new van to help mental health services in Jackson
Rep. Schmaltz secures funding for innovative van to help people in need State Rep. Kathy Schmaltz has secured $210,000 in the new state budget for LifeWays, the Jackson-Hillsdale Community Mental Health program, to purchase an Innovative Mobile Mental Health Crisis Unit that will expand access to mental health services throughout Jackson County. The innovative unit […]
Trump announces staff secretary Will Scharf, who helped secure ballroom approval, will be his new White House counsel
Democrats have vowed to pursue investigations into Trump and his administration if they are successful in November.
Scientists Release Biggest 2D Map of the Universe
Key Takeaways The DESI Legacy Imaging Surveys combined more than 263,000 telescope exposures to make the largest 2D map of the universe in visible and near-infrared light. Astronomers can pair the Legacy Surveys map with their own observations to explore our universe and search for rare phenomena. The 2D map serves as the foundation for the Dark Energy Spectroscopic Instrument survey to measure the universe in 3D and investigate dark energy. Hold on to your telescopes: the DESI Legacy Imaging Surveys team has released the largest-ever 2D color map of the universe. The 5.6-trillion-pixel map contains nearly 4 billion celestial objects, primarily stars and galaxies. The data is available for all to use and publicly viewable through the Legacy Survey Sky Viewer. Astronomers and citizen scientists can explore the map or combine it with their own observations to better understand our universe. Researchers can search for rare phenomena like gravitational lenses, observe fleeting events like supernovae, and investigate two of physics’ biggest mysteries: dark matter, the invisible substance that accounts for most of the mass in our universe, and dark energy, the force driving our universe’s accelerating expansion. The new map builds on earlier versions from the DESI Legacy Imaging Surveys that have already proved invaluable. To date, more than 1,800 science papers that reference the Legacy Surveys data have been published. “It’s part of the fabric of astronomy research now,” said David Schlegel, a co-lead of the Legacy Surveys and scientist at the Department of Energy’s Lawrence Berkeley National Laboratory (Berkeley Lab). “When you’re working with astronomical objects today, you often start by pulling up the Legacy Imaging Viewer to see what you’re looking at.” Covering roughly 75% of the sky in visible and near-infrared light, the updated map provides a deep view of the extragalactic universe not blocked by the dust and stars of our own Milky Way. Researchers expect it will remain the most comprehensive 2D map of our universe for years to come. More than 160 scientists contributed to data collection for the project, and a team of 20 produced the final dataset released today. It was built by combining 263,407 telescope exposures from three ground-based sky surveys: the Dark Energy Camera Legacy Survey (DECaLS) at NSF Cerro Tololo Inter-American Observatory, the Mayall z-band Legacy Survey (MzLS) at NSF Kitt Peak National Observatory, and the Beijing-Arizona Sky Survey (BASS) at the University of Arizona’s Steward Observatory. That was supplemented by years of data from NASA’s Wide-field Infrared Survey Explorer (WISE) satellite mission and additional public data. “For our team, these data are fundamental to our investigation of the expansion history of the universe and the formation of our galaxy,” said Arjun Dey, co-lead of the Legacy Surveys and an astronomer at NSF NOIRLab. “But the skies belong to everyone, and this survey gives everyone the chance to explore the sky and marvel at its wonders.” Here be galaxies The DESI Legacy Imaging Surveys were originally conducted to prepare for the Dark Energy Spectroscopic Instrument (DESI) survey. The Legacy Surveys’ 2D map is essentially a deep photograph of the sky; it records where galaxies and stars appear and how bright they appear. This crucial step enables DESI to select objects and measure their light in different wavelengths to determine their distances, building the largest high-resolution 3D map ever made. Scientists study the way galaxies have clustered at different ages of the universe to track dark energy over time. In April 2026, DESI completed its original five-year survey ahead of schedule and with vastly more objects than expected. The early results have shown surprising hints that dark energy’s impact may be weakening over time — a paradigm shift that could potentially shape the predicted fate of our universe. DESI expects to publish improved results using their first five years of data in 2027 and is continuing observations into 2028. DESI was so efficient at observing galaxies, the Legacy Surveys map needed to expand. Early on, “it became clear we might run out of galaxies to look at and run out of sky, and we better start doing something about that,” said Schlegel, who also works on DESI. The new Legacy Surveys map has been used to select DESI targets since June 2026 and will guide the telescope’s operations over the coming years. Computing the cosmos Merging hundreds of thousands of images taken on 2,285 nights, each with unique atmospheric and telescope conditions, was a massive computational effort. It took about a year to develop the computer code and eight weeks to process all the images at the Perlmutter supercomputer at the National Energy Research Scientific Computing Center (NERSC) at Berkeley Lab. Beyond supporting DESI, the Legacy Surveys will be a foundational reference for the next generation of telescopes. As new observatories like the NSF-DOE Vera C. Rubin Observatory (jointly funded by NSF and DOE’s Office of Science) and NASA’s Nancy Grace Roman Space Telescope come online, researchers can compare their observations with one of the deepest and most comprehensive views of the sky ever assembled. The Legacy Surveys data will also help scientists train artificial intelligence tools to analyze petabytes of astronomical data and accelerate new discoveries. It will be among the datasets used in an astrophysics pilot project within the American Science Cloud, part of the DOE’s Genesis Mission. The DESI Legacy Imaging Surveys are supported by the U.S. Department of Energy’s Office of High Energy Physics; the National Energy Research Scientific Computing Center, a DOE Office of Science user facility; the U.S. National Science Foundation, Division of Astronomical Sciences; and the partner institutions. DESI is supported by the DOE Office of Science and NERSC. Additional support for DESI is provided by the NSF; the Science and Technology Facilities Council of the United Kingdom; the Gordon and Betty Moore Foundation; the Heising-Simons Foundation; the French Alternative Energies and Atomic Energy Commission (CEA); the Secretariat of Science, Humanities, Technology and Innovation (SECIHTI) of Mexico; the Ministry of Science and Innovation of Spain; and by the DESI member institutions. ### Lawrence Berkeley National Laboratory (Berkeley Lab) is committed to groundbreaking research focused on discovery science and solutions for abundant and reliable energy supplies. The lab’s expertise spans materials, chemistry, physics, biology, earth and environmental science, mathematics, and computing. Researchers from around the world rely on the lab’s world-class scientific facilities for their own pioneering research. Founded in 1931 on the belief that the biggest problems are best addressed by teams, Berkeley Lab and its scientists have been recognized with 17 Nobel Prizes. Berkeley Lab is a multiprogram national laboratory managed by the University of California for the U.S. Department of Energy’s Office of Science. DOE’s Office of Science is the single largest supporter of basic research in the physical sciences in the United States, and is working to address some of the most pressing challenges of our time. For more information, please visit energy.gov/science.
Congressional Democrats to investigate efforts to deport U.S. military members and their families
The Pentagon declined to comment, stating it would "reply directly to the authors of the letter."
2001-02 Men's Basketball Team To Be Inducted Into Washington DC Sports Hall of Fame
The Washington DC Sports Hall of Fame announced today that the 2001-02 NCAA National Champion Maryland men's basketball team will be part of its Class of 202...
Apple reportedly considers screenless wearables in effort to revamp Apple Watch lineup
An overhaul of Apple Watch may be coming, but not right away.
Gen Z calls it ‘loud budgeting’ – small business owners have been doing it for decades
The practice of openly proclaiming to the world what you can’t afford can lead to lower fees, reduced prices and better deals
Mission-Driven Mondays: Morris Museum builds community through art, science and curiosity
Morris Museum President and CEO Tom Loughman shares how the Morris Township institution uses art, science and performance to build community.
Men’s Basketball’s Amaker to be Inducted into Washington DC Sports Hall of Fame
Tommy Amaker, The Thomas G. Stemberg '71 Family Endowed Coach for Harvard Men's Basketball, will be inducted into the Washington DC Sports Hall of Fame as part of its Class of 2026, it was announced today.
Bethesda Veteran Reveals How He Would Have Designed Starfield Differently
A former Bethesda developer who worked on Skyrim, Fallout 3, Fallout 4, and Fallout 76 has outlined how he would have designed Starfield had he been in charge of the game — and it sounds very different.
Custom Recipes: Play fantasy with new preset scoring formats
Custom Recipes mark Day 1 of the 29 Days of Fantasy.
Yahoo Sports' Preseason College Football Top 25: Can Texas A&M get over Texas hurdle and play for SEC title?
Italy-Spain fallout: united by geography, divided by politics
Italy and Spain's Schengen border spat over Ceuta has exposed a deeper migration rift, as domestic politics and rising far-right rivals harden both sides' positions.
AP Decision Notes: What to expect in Connecticut’s state primary
Two veteran Democratic incumbents in Connecticut face strong challenges in a state primary on Tuesday.
What the Senate did and didn’t get done in the final hours before recess
Before leaving Saturday, lawmakers confirmed President Trump’s attorney general pick and passed a spending bill.
AbCellera women’s health data top ‘most aggressive upside scenario,’ putting Astellas and Bayer on notice
AbCellera has reported phase 2 results “beyond even the most aggressive upside scenario” that its CEO dared to consider, boosting the biotech’s chances of challenging Astellas and Bayer for a women’s health market. The phase 2 clinical trial compared ABCL635, an antibody targeting NK3R, to placebo in patients with hot flashes caused by menopause. Investigators enrolled 92 postmenopausal women experiencing a mean of about 10 moderate or severe hot flashes per day. By Week 4, the number of moderate or severe hot flashes had fallen by a mean of 8.8 on ABCL635 and by 3.5 on placebo. That statistically significant, placebo-adjusted reduction of 5.3 hit the trial’s primary endpoint. The level of efficacy also cleared the bar set by existing drugs. While cross-trial comparisons can be misleading, AbCellera CEO Carl Hansen, Ph.D., had seen enough to start hyping the program. “We now view ABCL635 as a potential best-in-class non-hormonal therapy with strong differentiation against approved NK3R competitors across all important dimensions, including efficacy, safety, dosing and convenience,” Hansen said on a Monday morning conference call with investors to discuss the data. “We believe ABCL635 is now a highly de-risked program.” Last week, Hansen used AbCellera’s earnings call to set expectations for readout, with the CEO defining success as a clean safety profile and efficacy comparable to the two approved small molecules. The data vaulted over that bar. Astellas linked (PDF) one of the small molecules, Veozah, to placebo-adjusted reductions in hot flash frequency of 2.1 and 2.6 at Week 4 of its two phase 3 trials. Bayer reported (PDF) placebo-adjusted reductions of 3.04 and 3.29 at Week 4 of pivotal studies for its small molecule, Lynkuet. At 5.3, the placebo-adjusted reduction in AbCellera’s trial comfortably cleared the standard set by the incumbents. Veozah and Lynkuet came to market based on evidence of their ability to reduce the frequency and severity of hot flashes. AbCellera’s phase 2 study covered both endpoints, with the Canadian biotech reporting a mean reduction in severity of 1.4 points at Week 4 on ABCL635, compared to 0.3 points for placebo. Again, the placebo-adjusted result compares favorably to data on Veozah and Lynkuet. Analysts shared Hansen’s enthusiasm for the data. The phase 2 results “firmly validate ABCL635 as a potentially best-in-class treatment,” BMO Capital Markets analysts said in a note to investors Monday. ABCL635’s apparent efficacy edge “is likely attributable to the higher dosing/target engagement the asset is able to reach vs. the oral agents due to its wider therapeutic index,” the analysts added. The analysts, who model $2.3 billion in unadjusted peak sales for ABCL635, flagged the safety profile as another positive of the phase 2 readout. While Veozah carries a boxed warning for liver damage, nobody on ABCL635 in the phase 2 trial had elevated liver enzymes or bilirubin values. If replicated in phase 3, the lack of a liver signal could allow approval without the monitoring requirements imposed on Veozah. Investors appeared equally enthused, sending AbCellera's stock up 32% to $9.21 in premarket trading Monday from a Friday closing price of $6.93. Next, AbCellera will collect the Week 12 data and talk to its advisors about further development. The results open up “a wide variety of possibilities of how we might take this forward into phase 3 studies to truly maximize the value of the asset and make sure that ABCL635 is able to demonstrate its differentiation potential,” Sarah Noonberg, M.D., Ph.D., AbCellera’s chief medical officer, told investors.
New TV shows to watch this week: Tune in to 'The Shards' on FX, stream 'Sterling Point' on Prime Video and revisit 'Sense8' on Netflix
Teen drama fans will fall for "Sterling Point" and "My Life with the Walter Boys." But don't overlook Taylor Sheridan, "Ted Lasso" or a gripping Netflix series.
Aliens: Fireteam Elite’s cloud version on Switch has been shut down, making it unplayable for those who bought it
The game is now entirely unplayable on Switch because it relied on cloud servers…
Louisiana health officials warn of vibrio case rise
🚨 A jump in Vibrio vulnificus cases is prompting Louisiana health officials to urge caution around certain exposures to salt water and raw seafood. The bacteria is known for causing a "flesh-eating" infection. Nine people have been hospitalized, and five have died this year, officials said Thursday. (Press release)
Ella’s Top Corral celebrates 50 years of business
On Aug. 6, Ella, the woman behind the name of ‘Ella’s Top Corral,’ celebrated her birthday.
Ella’s Top Corral celebrates 50 years of business
On Aug. 6, Ella, the woman behind the name of ‘Ella’s Top Corral,’ celebrated her birthday.
New rules for federal funding would threaten critical research, St. Louis scientists say
“Those are profound changes to how science would be administered in America."
Michigan Athletics to Host Elevate HER Summit
The University of Michigan Athletic Department will host the Women in Sports: Elevate HER Summit on Thursday, Oct. 15, at Crisler Center on the Stephen M. Ro...
Roads and dams put European eels at risk, scientists offer strategy to save them
An international team of scientists have put forth recommendations, published in Global Ecology and Conservation, for conservation strategies that could save the species from extinction .
RFK Jr. slated to unveil plan targeting loophole that allows chemicals in food supply
The practice known as “generally recognized as safe” allows companies to self-certify the safety of certain food chemicals or substances without strict government oversight.
‘I don’t think this is a good idea’: Veteran Bethesda world artist says Starfield having 1,000+ planets was the wrong move
“I would have done a handful of planets with bespoke layouts”, the Fallout 3/4…
With Medicaid cuts ahead, Louisiana’s rural health providers battle over payments
As the pool of Medicaid patients shrinks and Medicaid funding runs up against new limits, independently owned health clinics will receive a much larger share of what’s available once their new reimbursement rates go into place.
NFIB July Jobs Report: Small business employment index ends four straight months of decline
NFIB said on Aug. 7 that its July Jobs Report shows that the Small Business Employment Index rose after four consecutive months of decline.
Gloucester decide against Villa Park return
Gloucester Rugby confirm they will not be returning to Villa Park to face Leicester Tigers in the Prem next season.
Wisconsin, Minnesota primaries are next to feature progressive clash with Democratic establishment
Progressive candidates for governor in Wisconsin and U.S. Senate in Minnesota are making their final pushes ahead of Tuesday’s election
Count Binface, the man in a can with a plan, seeks Parliament seat in Britain's wackiest election
Count Binface, an intergalactic comedic candidate with a garbage can on his head, is at the center of the U.K.’s political universe
Good aliens, bad aliens and wisecracking wisdom — the best new science fiction books
YouTuber Sam A Miller reworks ‘Flowers for Algernon’ in a debut collection of future tales, while rebel groups hold out after Earth is invaded in ‘The Peace Child’
Nashville SC's Cristian Espinoza returns with a flourish
Forward, who hadn't played since May due to injury, scored twice for Boys in Gold in 4-1 Leagues Cup victory
Clemson Legend Cade Klubnik is Hearing Some Loud NFL Concerns
Former Clemson Tigers quarterback Cade Klubnik is under the microscope with the New York Jets.
Health officials urge caution for Gulf Coast beachgoers during surge of deadly bacterial infections
As many as one in five Vibrio vulnificus infections are fatal, a much higher rate than other types of Vibrio bacteria.
Nets Rookie Brown Jr. Embracing New York Spotlight
From shattering records at Louisville to elite mentorship from Rajon Rondo, the sixth overall pick brings high-octane scoring and defensive grit to Brooklyn’s ambitious new era.
Rebecca Sowden to Head Up Publicis Sport & Entertainment NZ
Little Black Book, The former New Zealand women's football representative will oversee the strategic and commercial direction of the offering
Trump picks longtime aide Will Scharf as new top White House lawyer
The White House staff secretary replaces David Warrington, who is leaving for the private sector.
I tried to fly business class and leave my kids in coach. It did not go well
Chalk it up to a failed experiment.
'Football 301' predicts win totals for the AFC West, where the Broncos look to maintain, Chargers look to take a big step and Patrick Mahomes gets help
Trump announces staff secretary Will Scharf will be his new White House counsel
President Donald Trump says Will Scharf will be the new White House counsel, replacing David Warrington.
Trump announces staff secretary Will Scharf will be his new White House counsel
President Donald Trump says Will Scharf will be the new White House counsel, replacing David Warrington.
How to spot the Perseid meteor shower, a summer light show that promises to dazzle
The meteor shower's peak Wednesday night into Thursday morning coincides with a total solar eclipse across Spain, Iceland and Greenland and a six-planet parade — though the best time to view the fireballs will come after totality.
Truck crashes into business in northwest Harris County
Precinct 4 constable deputies are investigation crash on Huffmeister Road in the Cypress area off the Northwest Freeway.
How hospital monopolies are driving up the cost of your health care
More than a million times a year, a U.S. surgeon slices open a knee, strips out worn cartilage, caps the leg bones with metal and drops in a plastic spacer to allow the new joint to glide. But while these knee-replacement procedures have become standard, the prices charged have not.Subscribe to The Post Most newsletter for the most important and interesting stories from The Washington Post. At Catawba Valley Medical Center in Hickory, North Carolina, for example, the cost of the procedure under
Fallout 76 Creative Director Promises 'Dark Content' Coming Soon
Jon Rush, the Creative Director on Fallout 76, has revealed that DARK CONTENT is coming soon to the post-apocalyptic MMORPG.
Alexandria Ocasio-Cortez says she’s freezing her eggs
The Democratic congresswoman, 36, said she made the decision to undergo the fertility procedure to “feel more in control of my life.”
Sinner Joins Alcaraz in Withdrawing From Cincinnati, Clouding US Open
Carlos Alcaraz previously withdrew from Cincinnati with a wrist injury.
El-Sayed spoke with Obama as Michigan Democrats look to unite after a bitter Senate primary
“I was grateful for his advice. It was very warm, very inviting, and I know that he knows the critical role that Michigan is going to play,” El-Sayed told NBC’s “Meet the Press."