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Texas high school football team forfeits game amid mounting injuries
Gainesville ISD has forfeited Friday's football game because of mounting injuries, leaving the team's season finale uncertain.
What Would Democrat Xavier Becerra Prioritize If Elected Governor?
Democrat Xavier Becerra walks through his day one priorities if elected governor.
Health Brief: Election Watch | Rising health costs become a key issue in governors’ races
Plus: Medicare drug plan costs rising by 50 percent
Top Oregon health official skipped report warning long-term seclusions had become common at state hospital
A state investigation found the official had not reviewed a consultant’s report that flagged the problem months before a patient died after 7 months in a seclusion room.
Halloween comes knocking at UVA Health Children’s, bringing joy to young patients
Halloween usually means putting on a costume, grabbing a bag and heading out to collect candy.
“Criminal Minds” to end again — this time with season 20
The series initially wrapped in 2020, before being revived as “Criminal Minds: Evolution.”
Ian McKellen pens tribute to Patrick Stewart after star's death
Ian McKellen honored Patrick Stewart after his death at 86, recalling their start as young Royal Shakespeare Company actors before becoming close friends through 'X-Men.'
Women could soon buy this life-saving drug over the counter
Some types of vaginal estrogen could become available over the counter, a top official tells USA TODAY. It could help prevent UTIs in menopause.
Without Dylan Larkin, Red Wings Depth Forward Becomes Detroit Sports Longest Tenured Athlete
DJ Moore receives questionable tag for Week 8
Bills WR DJ Moore has a chance to play in Week 8 after limited work Friday
2026-2027 Audree V. Fowler Fellows in Protein Science
Graduate students Lenka Milojević (Zhou group), Akshaya Narayanasamy (Lindert group), Sarah Singleton (Conway group), and Janet Zhong (Feigon group) have been selected as 2026–27 Fowler Fellows and shared their research at a special event on Oct. 13, 2026. 2026-27 Fowler Fellows – Sarah Singleton, Lenka Milojević, Janet Zhong, and Akshaya Narayanasamy. Akshaya Narayanasamy and Prof. Steffen Lindert. Sarah Singleton and Prof. Stuart Conway. Janet Zhong and Prof. Juli Feigon. About the 2026-27 Audree Fowler Fellows in Protein Science Lenka Milojević is a fifth-year Biophysics Ph.D. candidate in the lab of Professor Z. Hong Zhou at UCLA. As an undergraduate at Maastricht University, she studied the structural basis of Mycobacterium tuberculosis virulence and amyloid-β fibril nucleation in the lab of Professor Peter Peters. She completed her bachelor’s thesis research at UCLA in the lab of Professor David Eisenberg, focusing on amyloid disaggregation, before beginning her doctoral studies. In the Zhou lab, Lenka uses cryo-electron tomography to visualize and characterize membrane-associated protein assemblies across a range of viral and cellular systems. Akshaya Narayanasamy is a fifth-year Ph.D. student in the Department of Chemistry and Biochemistry at UCLA, mentored by Professor Steffen Lindert. She earned her B.S.-M.S. in Chemistry from the Indian Institute of Science Education and Research, Thiruvananthapuram, where she worked in Professor Mahesh Hariharan’s lab investigating how single-atom substitutions influence crystal packing and charge transport behavior. She received her M.S. in Physical Chemistry from The Ohio State University before moving with the Lindert lab to UCLA. At UCLA, Akshaya develops integrative modeling methods that combine deep learning and Rosetta with experimental data, such as ion mobility mass spectrometry and cryo-EM, to improve protein structure prediction. Her current work focuses on developing an experimentally guided diffusion model and designing de novo protein binders with potential antibacterial activity. Ultimately, she aims to bridge AI-based structure prediction and experimental data to make computational protein models more reliable for drug discovery and therapeutic design. Sarah Singleton is a 4th year BMSB student, working in Professor Stuart Conway’s lab. She earned her B.S. in Biochemistry at Simmon University (Fenway, MA). Her research is centered on drugging the previously undruggable class of proteins—transcription factors. Zinc finger (ZF)-containing transcription factor proteins typically contain multiple ZF motifs, but little is known about the principles that govern the recognition of multi-ZF arrays by immunomodulatory imide drugs (IMiDs). In a multi-ZF array that contains several potentially targetable ZFs, which will be accessible and why? How does the surrounding protein architecture inform IMiD recognition? Sarah’s research aims to utilize her findings on the fundamental principles of ZF recognition to design IMiD therapeutics for transcription factors involved in health and disease. Janet Zhong is a fourth-year BMSB student, working in Professor Juli Feigon’s laboratory. She received her BSc and MRes from Imperial College London. At UCLA, Janet combines cryo-electron microscopy (cryo-EM) and biochemical approaches to investigate how proteins and RNAs assemble into ribonucleoprotein structures. Her research focuses on telomerase, the enzyme that maintains chromosome ends, with interests in its structure, assembly, and mechanisms. She has also worked on capturing the cryo-EM structure of a small bacterial non-coding RNA called raiA motif RNA. About Dr. Audree Fowler A strong supporter of the basic sciences and medicine at UCLA, alumna Dr. Audree Fowler (B.S. ’56 chemistry, Ph.D. ’63 biochemistry) established the Audree V. Fowler Fellows in Protein Science in 2008. Fowler was Director UCLA Protein Microsequencing Facility from 1984-1999 and is a Researcher Emeritus of the UCLA Department of Biological Chemistry. She is one of the first four women to receive a Ph.D. from the UCLA Department of Chemistry & Biochemistry. In 2018, the women were awarded the department’s 2018 Alumni Legacy Awards in recognition of their achievements in life, and generous support and service to UCLA. “The sciences gave me a great life. Now I want to help others have access to the same opportunities I enjoyed,” Fowler explained when she established the Fowler Fellowships endowment. Applications for the fellowships are solicited from graduate students in the Molecular Biology Interdepartmental (MBI) Ph.D. Program, Biological Chemistry, and Chemistry & Biochemistry Departments. In addition to presenting their research at a special seminar, the recipients each receive a $5,000 award. Previous Fowler Fellows from the UCLA Department of Chemistry & Biochemistry 2025-26 – Nikki Cheung (Clubb Group), Jonathan Jih (Zhou Group), Eileen Olivares (Loo Group), and Lily Taylor (Rodriguez Group) 2024-25 – Andrew Goring (Clubb lab), Eric Pang (S. Clarke and Rodriguez labs), and Miranda Villanueva (Backus lab) 2023-24 – Alexandra Turmon (Backus lab), Cindy Wang (S. Clarke and C. Clarke labs) 2022-23 – Cody Gillman (Gonen lab), Declan Evans (Houk lab), Troy Lowe (S. Clarke lab), Ashley Julio (Backus lab), and Alex Stevens (Hong Zhou lab) 2021-22 – Weixian Deng (Wohlschlegel/Plath labs), Yi Xiao “Sean” Jiang (Eisenberg lab), Maria Flores (Rodriguez lab), Carter Lantz (Loo lab), and Logan Richards (Rodriguez lab). 2020-21 – Janine Fu (Loo lab), Calina Glynn (Rodriguez lab), and Jiahui Lu (Eisenberg lab) 2019-20 – David Boyer (Eisenberg lab), Orlando Martinez (Clubb lab) and John Muroski (Loo lab) 2018-19 – Scott McConnell (Clubb lab), Kevin Murray (Eisenberg lab), Rebeccah Warmack (S. Clarke lab) 2017-18 – Michael Hughes (Eisenberg lab), Yuxi Liu (Yeates lab), Kanishk Jain (S. Clarke lab) 2016-17 – Brendan Amer (Clubb Lab) and Jeff Vinokur (Bowie Lab) 2015-16 – Henry Chan (Feigon lab), Smriti Sangwan (Eisenberg lab), Nicholas Woodall (Bowie lab) 2014-15 – Dan McNamara (Yeates lab) 2013-14 – Alex Jacobitz (Clubb lab), Alexander Patananan (S. Clarke lab), Carly Ferguson (Loo lab) 2012-13 – Letian Xie (C. Clarke lab), Anni Zhao (Eisenberg lab) 2011-12 – Timothy Anderson (Clubb lab), Soohong Kim (Weiss lab) 2010-11 – Zeynep Durer (Reiser lab), Cecilia Zurita-Lopez (S. Clarke lab) 2009-10 – Luki Goldschmidt (Eisenberg lab), Kristofer Webb (S. Clarke lab), Sheng Yin (Loo lab) 2008-09 – Nathan Joh (Bowie lab), Neil King (Yeates lab) Photos courtesy of Helen Houldsworth, the Molecular Biology Institute.
West Virginia hemp business facing closure if new federal rules take effect
Over the past three and a half years, Moon Flower Hemp has become a staple of downtown Buckhannon, serving various cannabis products to adults from across West Virginia and beyond. However, decisio…
Four Royals Hit Free Agency as Kansas City Offseason Begins
A former starting second baseman leads the group of Royals who officially became free agents after the World Series ended.
Phoebe Bridgers, My Chemical Romance and all your Halloween club needs
Halloween in Los Angeles is not just Gay Christmas — it's become a pretty exceptional weekend for music, with top touring acts planning blowout stands around the occasion.
The Making Of: Tomb Raider (Game Boy) - 'The Editors Had to Retcon the Score Because It Was Higher than Pokémon and Zelda'
Matt Charlesworth on Lara's Nintendo debut
AI presents risks, opportunities for women
Artificial intelligence could pose particular challenges for women in insurance because they hold many of the administrative roles susceptible to automation, but the technology also presents…
Detroit Lions safety Kerby Joseph progressing toward 'a real practice'
The Lions will not have any play-time restrictions on Brian Branch in this week's game against the Minnesota Vikings
Syracuse University, Upstate Medical University Hospital Announce Landmark Athletics Healthcare Partnership
SUNY Upstate will become the official and exclusive hospital of Syracuse Athletics under a comprehensive sports medicine and marketing agreement.
Leo XIV has become the first pope in history to vote in a U.S. general election
Leo XIV has become the first pope to vote in a U.S. general election, casting a mail-in ballot in a contest that will decide America's future as the Trump era slowly comes to an end.
Small business Saturday, culinary edition
Small Business Saturday falls on November 28th this year, the Saturday after Thanksgiving, and it’s the perfect time to strengthen the Island’s local economy by promoting the importance of small businesses. Because the reality is that supporting local businesses isn’t just about shopping, it’s about investing in the well-being of our community. When we purchase […]
Traffic, business changes: 5 stories in Aggieland to catch up on
Catch up on Bryan-College Station news, including a new traffic signal, Hartt's Barbecue opening, Bryan ISD waivers, racket sports and a restaurant closure.
Mass Effect Studio Shut Down Because EA “Chose to Invest in Star Wars” Instead
Mass Effect was going toe-to-toe with Battlefront.
Will daylight saving time ever become permanent? Health experts hope not
Clocks turn back an hour this weekend. A new study warns that year-round daylight saving time would mean millions more dark school commutes, with greater risk of deadly crashes.
Dan Stevens teases his ‘nasty’ “Dexter” villain and his “RoboCop” series: ‘I’ve never had so many texts from guys over 35’
The “Downton Abbey” breakout will star as the Five Borough Killer, before becoming a cyborg law enforcer.
Big 12 commissioner Brett Yormark leaving on Jan. 31
Brett Yormark is stepping down as commissioner of the Big 12, effective on Jan.31, 2027, the conference announced on Friday.Yormark, who became the league's fifth commissioner in 2022, plans to take another job outside of college sports, per multiple reports.
Jacob Misiorowski First Since Sandy Koufax To Accomplish This
It hadn't happened in over 60 years
Contract Projections for top Rays free agents
Former General Manger Jim Bowden’s annual free agency column at the Athletic offers the keenest insights into contract projections out there. Usually this exercise is something skippable for Rays fans, as the likelihood the team will be spending top dollar is fairly low, but there’s an unusually high number of Rays-related free agents on the […]
Gen Z doesn’t think their degrees will land them work anymore, so they’re becoming their own bosses instead—and these college towns are thriving
As AI upends the job market, exclusive GoDaddy data finds a new wave of entrepreneurial activity taking root in some lesser-known college towns.
Pope Leo makes history by voting in US midterms
(CNN) — Pope Leo XIV has submitted a mail-in ballot for the US midterms, becoming the first pope to vote in a US election and likely the first to vote
Pope Leo makes history by voting in US midterms
(CNN) — Pope Leo XIV has submitted a mail-in ballot for the US midterms, becoming the first pope to vote in a US election and likely the first to vote
EA reportedly closed BioWare because it was forced to choose between Mass Effect 5 and Star Wars Battlefront 3
BioWare closed because EA faced a choice between sci-fi games Mass Effect 5 and Star Wars Battlefront 3, a new report says. And BioWare lost out.
Grizzlies rookie Cameron Boozer becomes second-youngest player in NBA history to record triple-double
Marsh Netherlands appoints new chief
U.S. firm Marsh McLennan Companies Inc. has appointedKristof De Bremme as chief executive officer of Marsh Netherlands, succeeding David Sanderse, who will become chairman of the Netherlands business…
Meet Massachusetts' Women power players: $164B impact
Meet the power players on the annual list from The Women’s Edge.
Science Begins With Wonder and Sometimes With a Salamander.
The Bar Harbor Story is generously sponsored by the Don & Beth Straus Center at Birch Bay Village. BAR HARBOR—The children had come to see the axolotls, those odd little salamanders with pink frills around their heads and the remarkable ability to grow back what they lose. But also there were stickers. There were crafts. There was the kind of excitement that makes a roomful of kindergarteners forget, for a little while, that sitting still is ever a requirement. And then there were the animals themselves, alive in their clear cases at the MDI Biological Laboratory, where 12 children from Pemetic Elementary School got to meet the creatures they had been learning about in class. “Do you love them?” their teacher, Carol Null, asked. The answer came back in a chorus. “I do!” “I do!” “I do too,” Null said, smiling. “I love them even more now.” That was the thing about a day at the lab. Science was no longer a picture in a book, or a word on a classroom wall. It had a face, a tail, and a set of extraordinary powers. And for a child, sometimes that is where wonder begins. Sometimes learning about science is about stickers. Sometimes it’s about bright pink feathers and getting super excited about that glow in the dark. Sometimes learning about science is joy—pure and simple joy. That’s how it was October 28 at the MDI Bio Lab as Miss Hannah (known in the lab as Dr. Hannah Lust, director of STEM, undergraduate and graduate Training), other scientists, graduate students, and MDI Bio Lab staff, hosted 12 students from Carol Null’s Pemetic Elementary School’s kindergarten class. The 2.5-hour program created by Dr. Lust focused on axolotls, a species of mole salamanders, a superhero in the animal world: a superhero with some scientific-study worthy superpowers. One of those superpowers come from the axolotls’ ability to regenerate body parts, including entire limbs. But also, they’re cute. This fall, before coming to the internationally renowned lab nestled in Salsbury Cove, Null has been integrating axolotls into her class. They’ve been part of the kids’ vocabulary and their storytelling. They’ve been part of science. They’ve been part of the children’s learning about facts vs opinions. The Pemetic Elementary kindergarten students learn about invasive species and the impact on the ecology and one student related it to their dad, who lobsters, and his worries about green craps, an invasive species in Maine. “Are they bigger or smaller than you thought they’d be?” the children are asked after the scientists show them multiple see-through cases of axolotls, lined up on a table that they’re told not to jiggle. “Bigger!” “I think they’re bigger.” “Smaller!” The bio lab opening its doors to the collaborations and to students and families is a norm, but this is the first program of this kind. It’s meant to encourage kindergarten students about axolotls. But when the students come to the bio lab something else happens too—something beyond Null’s child-focused teaching—the students see science—and the regenerating creatures in real life. They do crafts. They speak with them. They meet people who know all about them: scientists and educators who talk to the kids like they’re equals. That’s a superhero power, too. Null speaks about meeting the kids where they’re at in her classroom, letting their interest and hearts lead her in their learning. That requires recognition of interests, of individuality, of empathy. Some would argue that’s a super power, too, but it’s also in those 12 students as they listen to the storybook, encounter those live axolotls, and hear about how axolotls might help advance society’s understanding of human health. As Eddie Seckeler (comparative animal models, CORE facility manager), carefully puts the axolotls on a cart and rolls them away, some of the children stop what they’re doing to watch. “Bye axolotls.” “Bye!” “Bye!” The axolotls are not just images in a book, Hello, I’m an axolotl by Hayley and John Rocco; they are real and cool. MDI Biological Laboratory scientists Dr. Prayag Murawala and Dr. James Godwin who both feature in the Roccos’ book. The kindergarteners get to meet them in real life, off the page, in the world, doing science. They learn from them, laugh with them. “The visit is about more than meeting an unusual animal. By introducing children to scientists working in their own community, the experience helps make science tangible and accessible. Students can see that science is not just something they read about in books or learn about at school. It is something real people do every day by asking questions, making observations and working to understand how the world works,” explains MDI Biological Laboratory Director of Communications Rebecca Woods. While the students make axolotl-related crafts around tables, graduate students and staff help out. Ryan holds up his construction paper setting and axolotl to show Omar Maged, a graduate student. “Do you like it?” Ryan asks, eyes wide, turning from his axolotl to look up at Omar. Omar studies the construction paper for a moment, smiles and says definitively, each word important. “It is beautiful.” Null says that she’s so thankful for all the “amazing” community partners that her school and her students get to interact with as they learn and grow and live, but emphasized how the MDI Bio Lab goes out of its way to create something meaningful, something that allows her young students to build their own agency, to know that they can be impactful in their community, to show them how how things they learn about in text is connected to themselves and their community. Woods explains, “Axolotls have an extraordinary ability to regenerate, or regrow, certain body parts, including limbs. Scientists study these animals to understand how regeneration works and what their biology might teach us about tissue repair and healing in humans.” The children enter the space for “a memorable introduction to a big scientific question,” Woods said. “How can some animals regrow body parts? The encounter encourages children to look closely, wonder about what they see and begin to understand how scientists use observations and experiments to investigate questions.” “For the students, the visit is an opportunity to explore a fascinating animal and meet scientists in their own community,” Woods explains. “For MDI Biological Laboratory, it is a chance to share the excitement of research, nurture curiosity, and help young learners discover that science begins with asking questions.“ At the beginning of the school year, Pemetic kindergarteners didn’t know what the axolotl was—at least not exactly—now they know all about the axolotl’s life cycle. “It’s different than a butterfly,” one student told Mrs. Null. It is. The change and knowledge might seem small**,** but it offers a glimpse of what happens when a subject moves beyond the pages of a book and into a child’s world. The children have been learning about butterflies at the Charlotte Rhoades Park and Butterfly Garden. At both the garden and the MDI Bio Lab, the children see the animals, meet the scientists who study them and at the lab encounter a question that researchers are still working to answer: how can some creatures regenerate body parts, and what might that teach us about healing in humans? They leave with gift bags, paper-plate salamanders, new things to wonder about and a connection between the science they learn in school and the work happening in their own community. The axolotls may be remarkable for their ability to grow back what they have lost. For these young students, the day offers something different: a chance to discover how much there is to ask, observe, and imagine. When Null’s students had time to use chalk and draw whatever they want, in the beginning of the year, they drew rainbows. Now? They’re using that chalk and choosing to draw axolotls instead. About MDI Bio Laboratory For more than 125 years, MDI Bio Lab has been a center for training and research in comparative biology. In the last two decades its biomedical research has focused on aging, regeneration, and environmental toxins. The Laboratory houses 11 research groups staffed by an international team of world-class scientists and graduate students. It also leads a statewide network of colleges, universities and research institutions that collaborate to provide training, research experiences and financial support to help young Mainers play a bigger role in today’s biomedical revolution. Located on Maine’s rugged coast, the Laboratory’s 100+ acre campus houses research facilities, cottages and dorms that house visiting scientists and students. It is also home to MDI Bioscience, a subsidiary working to design innovative techniques to speed the drug discovery process. The Bar Harbor Story is generously sponsored by Rick Osann Art. LINKS TO LEARN MORE NIH INBRE MDI BIOLOGICAL LABORATORY Pemetic Elementary School Hello, I’m an Axolotl Photos: Carrie Jones/Bar Harbor Story HELP SUPPORT THE BAR HARBOR STORY When we started The Bar Harbor Story, we didn’t know if anyone would read it. But you showed up. You shared. You sent tips. Now—over 400,000 views every month later—it’s clear: people here care about their community and each other. We’ve kept everything free because news should never be out of reach, but every one of our stories takes time to write, and your support keeps The Bar Harbor Story going. If you value our work, please consider a paid subscription, a founding membership, or a sponsorship. It truly helps us cover one more meeting, tell one more story, shine one more light. Even $5 a month makes a difference. Click here to become a one-time supporter now. Thank you so much for being here. Founding member information can be found here. Have questions about sponsorships? Just send Shaun an email at sfarrar86@gmail.com, he’d love to hear from you. Subscribe Share Bar Harbor Story Share Leave a comment
Former Pasadena mall to become $75M health center as city faces healthcare access challenges
Harris Health is converting the former Dillard’s at Pasadena Town Square Mall into a $75 million, 60,000-square-foot Pasadena Square Health Center to consolidate three existing clinics and improve healthcare access.
Scientists Just Found Where the Quantum World and Our World Meet: Free Fall
Tom Petty’s famous song applies to all of us, because of Einstein’s equivalence principle of gravity in free fall.
Scientists Just Found Where the Quantum World and Our World Meet: Free Fall
Tom Petty’s famous song applies to all of us, because of Einstein’s equivalence principle of gravity in free fall.
Dodgers notes: Dave Roberts, Emmet Sheehan, Dustin May
The Commissioner’s Trophy resides in the city of Milwaukee for the first time in 69 years after the Brewers secured their first World Series championship. In doing so, they trampled over the Dodgers in a lackluster four-game series sweep, crushing the Dodgers’ dreams of becoming the first baseball team to three peat in 26 years. […]
EA Reportedly Closed BioWare To Invest In Developing Star Wars Battlefront III Instead Of The Next Mass Effect
EA purchased BioWare back in 2007 to make a Star Wars game that would become The Old Republic MMORPG. - Game Informer
Want to Lose Weight? Why Mixing Cardio And Strength Training Beats Any Single Workout
FRIDAY, Oct. 30, 2026 (HealthDay News) — Searching for the single best workout to help you lose weight? There isn’t one, a sports medicine doctor says, because the smartest approach is mixing different types of exercise. Switching between workout styles keeps the body challenged, which helps it keep ...
Hackensack Meridian Health Becomes First Hospital Network in the Northeast to Administer Pixclara®, the Only FDA-Approved PET Imaging Drug for Brain Cancer
New advanced imaging technology provides greater clarity, helping physicians distinguish between tumor growth and post-treatment scarring in adult and pediatric glioma patients.
Darius Acuff Jr. tied LeBron James, Zach LaVine and …
Darius Acuff Jr. tied LeBron James, Zach LaVine and …
Street Medicine at Ohio State works to expand health care access for Columbus’ unhoused population
Without stable housing, accessing health care can become a challenge for people experiencing homelessness. Ohio State Street Medicine, a student-led nonprofit organization, works to close that gap by providing medical care directly to unhoused individuals in Columbus. The organization holds six outreach events a month, offering services such as wound care and addiction medicine treatment. […]
You don’t have to be a farmer to buy farm bureau health coverage — which isn’t regulated as insurance
Because of a concern that they destabilize the market by siphoning off healthy consumers, short-term, limited-duration plans are banned in five states.
Zelda 40th Anniversary Switch 2 restock update: the Nintendo Store remains your best bet
🎮 The Zelda 40th anniversary Switch 2 was released on October 29 and flashed in and out of stock at the Nintendo Store 🚨 Our Zelda Switch 2 restock tracker @mattswider on X will send out an alert as soon as stock appears 👀 Walmart was our top pick to have a restock, but a supply chain delay has pushed the date back ⌚ In-store midnight launches are being held at GameStop, Best Buy, and Nintendo New York/San Francisco Walmart: Zelda Switch 2 console Best Buy: Zelda Switch 2 console GameStop: Zelda Switch 2 console Nintendo: Zelda Switch 2 console 🚨 We’re tracking Zelda Switch 2 stock updates. If you’d like to know when more stock arrives, follow Matt Swider on X and turn on notifications. You can also become a free or paid subscriber to The Shortcut to help support our work. 🚨 The Legend of Zelda 40th Anniversary Switch 2 launched yesterday, and it was the Nintendo Store that held the most restocks. The console flashed in and out of stock repeatedly throughout the day as limited units were sold and quickly snapped up. 🚨 Want the Zelda 40th Anniversary Switch 2? Drop your email for restock alerts before it sells out. ⤵️ Subscribe Many were met with error messages, “sold out” signs, or “couldn’t add the required amount” to their baskets. However, with a little persistence and luck, others were more successful. As it stands, it’s the best place to try to get the Zelda Switch 2, even if the experience can be a little frustrating. We’re expecting a similar situation today as our tracker continues to receive restock alerts. However, we’re reluctant to share them all as many have been false flags, but we immediately notified The Shortcut followers once the first restock went live. [ The Shortcut@theshortcut Zelda Switch 2 is back in stock at the Nintendo Store: nintendo.com Nintendo Switch™ 2 – The Legend of Zelda™ – 40th Anniversary Edition - Nintendo Official Site 4:18 PM · Oct 29, 2026 · 2.09K Views 2 Replies · 2 Likes ](https://x.com/theshortcut/status/2115840807773299128?a=b6yhtCFmoswv5lWWvEs&s=20) Amazon was the only other retailer to hold an online restock, though it sold out almost instantly. No more restocks took place, and sadly, the major Walmart restock of the Zelda Switch 2, which we were confident would take place, did not happen because of a supply chain issue. [ Matt Swider (The Shortcut)@mattswider ](https://x.com/mattswider/status/2115824408938111299?a=quc3qYd6I_Qe5wag2lU&s=20) 🚨 Zelda Switch 2 console at Amazon right now amazon.com/dp/B0HJ6F8L6V?… amazon.com Nintendo Switch™ 2 –The Legend of Zelda™ – 40th Anniversary Edition 3:13 PM · Oct 29, 2026 · 76.7K Views 32 Replies · 4 Reposts · 57 Likes The console will now be available to order online at Walmart on November 6, with Target also offering the same date. Some lucky shoppers could also get the Zelda Switch 2 in-store, with The Shortcut readers sharing their personal accounts of getting the console at Walmart and helping each other out. If you’re willing to travel to your local store, Best Buy and Nintendo are holding in-store events on November 5 (though you’ll need a Warp Pipe Pass for Nintendo’s event). GameStop is also letting customers pre-order in-store.. We’ll still be tracking every retailer with our exclusive Zelda 40th anniversary Switch 2 restock tracker, which provides up-to-the-second information when the Zelda Switch 2 is in stock. If the console appears – which it might – our followers will still be the first to know. Up next: PS5 Pro restock: it’s available again, but you’re paying more than you should Subscribe Adam Vjestica is The Shortcut’s Senior Editor. Formerly TechRadar’s Gaming Hardware Editor, Adam has also worked at Nintendo of Europe as a Content Marketing Editor, where he helped launch the Nintendo Switch. He also runs a retro gaming YouTube channel called Game on, boy! Follow him on X @ItsMrProducts.
Why healthcare has become such a big problem for Republicans
The GOP hoped to keep Medicaid cuts out of the midterms. It’s not working.
Ohio State vs. USC: 2026 game preview and prediction
Ohio State will be seeking their first win at USC since 1946 on Saturday night when they travel to Los Angeles to take on the Trojans
Excuses from Pirates, Bob Nutting don't hold up against Brewers World Series victory
The Brewers occupy a smaller TV market than the Pirates, and yet they've become MLB's dominant team as Pittsburgh has complained.
Exclusive | Asian scientists are looking to South Korea as it becomes harder to stay in the US
Seoul university says it’s luring researchers in energy, quantum materials and biomedicine while still working with US and Chinese partners.
Giant eagles once ruled the skies. They snatched human children, and shaped our evolution
After the dinosaur-killing asteroid hit, giant birds became apex predators for tens of millions of years – and humans were among their prey.
How a Cleveland firm became a leading preservationist of historic North Carolina real estate
Cleveland-based GBX Group has its second-highest concentration of assets in Asheville, N.C.
Guest Commentary: With political division, it’s imperative to keep children out of it
Parents should vote, speak about, volunteer and teach their children the values that guide their lives. But children should not be enlisted in political fights.
The politics of war
Israel went to the polls last Tuesday and it is the turn of the United States next Tuesday. The differences in the two elections are self-evident. Compared with the US, which has favourable geography and does everything at scale, Israel is tiny and part of an unstable region. For its elections, it has adopted an almost pure form of proportional representation based on lists. This encourages multiple parties and can make it almost impossible to form a government, as we can now see. The US system is complex in its own way but discourages third parties. Yet for all the differences in size, geography, and political systems, the fates of the two countries are closely connected. Israel has come to depend on the US to sustain its military strength, and over the past few tumultuous years that dependence has created resentment in the United States. The Biden administration was punished for appearing to give Netanyahu a blank check after the Hamas attacks of 7 October 2023, and not holding Israel back as it employed ruthless tactics in Gaza. Because of the treatment of Palestinians, American views of Israel have grown progressively more negative over the past few years. Only a third now support the Israeli government. While on the left, this is largely because of how Israeli forces have operated in Gaza and, more recently, how the settler movement has behaved in the West Bank, for the American right the issue has been about how Benjamin Netanyahu persuaded Donald Trump to forget his wariness about more Middle Eastern wars and agree to a joint attack on Iran, which has gone badly wrong. The Palestine question was not a big issue for the two large Jewish blocs in last Tuesday’s election. Both supported a tough response to Hamas after October 2023 and neither accepts a two-state solution. It was, however, the threat posed by the ethno-nationalist policies of Itamar Ben-Gvir and Bezalel Smotrich, the two extreme members of Netanyahu’s coalition, and their tolerance, even encouragement, of settler violence, that brought out the Arab voters. (In principle this should strengthen their position though to turn into real power would require the ‘Change Bloc’ overcoming their opposition to involving Arab parties. The alternatives are a National Unity government, defection from the Change Bloc to Netanyahu, or deadlock and another round of elections in the new year.) There was also broad support for the war against Iran among the Jewish parties. The difficulty here is that the objectives behind the war have yet to be met, and that continuing with military operations depends on the United States. In this way the two elections have come together at a crucial moment. If Netanyahu hoped that a victory over Iran would help him retain his majority, cementing his legacy as an Israeli war leader, it did not work out that way. Trump also expected a great victory about which he could boast. He promised at most the end of a hateful and aggressive regime, with a record of hostility to both the United States and Israel, or at least the elimination of Iran’s military capabilities and the end of its nuclear programme. Eight months on, there is not much to boast about; vital objectives remain elusive: the Iranian regime is even more hardline than before; the international economy is barely coping with the closure of the Strait of Hormuz; and Saudi Arabia is struggling with an unwanted conflict with the Yemeni Houthis. For all these reasons, the Iran War has been a dark cloud hanging over both elections. Yet the issue has been approached in different ways. Netanyahu sought to push the issue before the election while Trump has been more cautious. Trump’s essential claim is that there is nothing to worry about and he’s still working out what final steps need to be taken to provide a definitive conclusion to the conflict. Netanyahu’s final pitch was that there was lots to worry about. He focused on Israel’s dire security situation, with the Iran War unfinished and the prospect of imminent economic isolation because of international sanctions. For him it is imperative to defeat Iran decisively, and without delay. Why this different response to the same war? Part of the answer lies in how public opinion in the two countries responded to the war. In this post, I show how this came about. We await the outcome of the US midterms but know the result, at least in terms of the share of the vote if not yet the shape of the new government, of the Israeli election. With the elections out of the way Netanyahu is pressing for another round in the war. Trump is less sure. I conclude with thoughts on the importance of how he decides.
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🎮 The Zelda 40th anniversary Switch 2 is out today, October 29, but Walmart and Target are planning online restocks for November 6 🚨 Our Zelda Switch 2 restock tracker @mattswider on X will send out an alert as soon as stock appears 👀 Walmart was our top pick to have a restock, but a supply chain delay has pushed the date back ⌚ GameStop, Best Buy, and Nintendo are holding in-store midnight launches where units will be available Walmart: Zelda Switch 2 console Best Buy: Zelda Switch 2 console GameStop: Zelda Switch 2 console Target: Zelda Switch 2 console Nintendo: Zelda Switch 2 console 🚨 We’re tracking Zelda Switch 2 stock updates. If you’d like to know when more stock arrives, follow Matt Swider on X and turn on notifications. You can also become a free or paid subscriber to The Shortcut to help support our work. 🚨 A new update has dashed our hopes of a major Walmart restock of the Zelda Switch 2 console, which we were confident would happen today. However, a new Reddit post (thanks, Wario64) has revealed that Walmart is waiting until at least November 6 to sell the special edition console online. 🚨 Want the Zelda 40th Anniversary Switch 2? Drop your email for restock alerts before it sells out. ⤵️ Subscribe A employee note says: “Due to a supply chain delay, some stores may not receive the Nintendo Switch 2 Zelda 40th Anniversary Edition in time for its planned Oct. 29 release. To allow time to fulfill preorders and reshop inventory as needed, the point-of-sale (POS) block will remain in place through at least Friday, Nov. 6. As inventory arrives, orders will be fulfilled based on preorder priority and available inventory.” The Redditor who posted the news shared that some people were able to get the console from Walmart after 8:00am local time, so there is still hope. Target recently updated its Zelda Switch 2 listing to reveal that it will also start taking orders of on November 6, with in stores orders beginning November 5. Clearly, the supply chain delay is impacting other stores, otherwise we likely would have seen a restock take place today, as we initially predicted. We now know that Walmart and Target will be taking online orders, and that Best Buy and Nintendo are holding in-store events on November 5. GameStop is also letting customers pre-order in-store via their website. Despite the news, we’ll still be tracking every retailer with our restock tracker, which provides up-to-the-second information whether something is in stock. If the Zelda Switch 2 does appear – which it might – our followers will still be one of the first to know. Up next: PS5 Pro restock: it’s available again, but you’re paying more than you should Subscribe Adam Vjestica is The Shortcut’s Senior Editor. Formerly TechRadar’s Gaming Hardware Editor, Adam has also worked at Nintendo of Europe as a Content Marketing Editor, where he helped launch the Nintendo Switch. He also runs a retro gaming YouTube channel called Game on, boy! Follow him on X @ItsMrProducts.
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The Israel debate reshaping Jewish American politics
“There are plenty of people who believe, as I do, that Israel has a right to protect itself,” says David to Lauren, both pictured below, over the dinner table. Subscribe “How does starving children protect Israel?” she replies. “I don’t think Israel is intentionally starving children.” “It’s a little bit absurd to be sitting here talking about all of these very specific things,” Lauren says, “as opposed to looking at the totality of him as a candidate, and the 90% of things that you agree with him on.” This is a snapshot from a conversation between a Jewish father and daughter in Michigan ahead of the crucial Senate race. Lauren supports the Democratic candidate, Abdul El-Sayed. Her father is undecided. That is mainly because of El-Sayed’s stance on Israel, one that mirrors a growing wing of the party that has become critical of the US-Israel relationship following the war in Gaza. You’re reading FourSight, a newsletter from Channel 4 News’ expert journalists explaining the complexities of the biggest global stories Could that alienate Jewish American voters who have a strong connection to Israel - and the majority of whom have voted Democratic? A shifting stance on Israel “An ally that takes your money to push you into wars you shouldn’t be fighting is not an ally,” El-Sayed recently told ABC News, referring to the Iran war and how some Americans believe that Israel pushed President Trump into the conflict. Foreign policy has become an economic issue that’s hitting Americans’ pockets, with the soaring cost of petrol and diesel. El-Sayed, pictured below, has opposed military aid for Israel and accused the nation of genocide in Gaza. That led to the pro-Israel lobby group, AIPAC, funding his opponent, Hayley Stevens, to the tune of $30m during the Democratic primary here. “I frequently criticise AIPAC because I think the way that they are pouring dollars into defeating Abdul and others around the country… is really corrosive to American democracy,” Brad Lander says at a canvassing event in Detroit. Lander, a Jewish Democratic congressional candidate in New York, is an ally of Mayor Zohran Mamdani and has come to campaign for El-Sayed. “Democrats and Americans don’t want to keep paying for Netanyahu’s wars,” he says. “They want a reset in the US relationship with Israel.” The 2026 election has clearly been a bruising one for AIPAC; the Wall Street Journal reported that, in an unpublished letter, the group described the cycle as one of the “most challenging environments in recent memory”. Share And significantly, after the midterms, the group will stop direct contributions to candidates through one of its political action committees. Voters’ concerns We followed a group of Jewish canvassers around one suburb in Detroit. They think that among the 130,000 Jewish voters in Michigan, between 20 and 30,000 are undecided. In a swing state where El-Sayed beat his primary rival by just 13,000, that could prove pivotal. We meet one voter, Jen Friedman, pictured below, who has a “Democrats for Rogers” sign, referring to the Republican candidate. The issue of Israel is very important to her because “having a safe haven is crucial”, she tells me. “What I see is one candidate, Mike Rogers, who is associating himself with people who are very proudly American,” says Jen. “Abdul, on the other hand, is associating with people who say they are anti-American.” Friedman raises two issues. Firstly, Hasan Piker, a left-wing streamer who has campaigned alongside El-Sayed and has been criticised for his comments on the US and Israel. [ ](https://channel4news.substack.com/p/who-is-hasan-piker-the-socialist) [ Why Hasan Piker thinks the US needs a socialist Trump ](https://channel4news.substack.com/p/who-is-hasan-piker-the-socialist) Anushka Asthana · Aug 19 [ Read full story ](https://channel4news.substack.com/p/who-is-hasan-piker-the-socialist) The other concern regards an attack on a Michigan synagogue back in March. The FBI said the man was inspired by Hezbollah and had lost relatives in an Israeli airstrike on Lebanon. El-Sayed condemned the antisemitic attack, but also said “hurt people hurt people”. That upset many here, with El-Sayed apologising numerous times for his choice of language. Jews for Abdul As we follow the canvassers, there are still plenty of lawn signs supporting El-Sayed. Elissa Driker, pictured below, runs out of her house wearing a “Jews for Abdul” t-shirt. “I feel like the values that Abdul has align with how I live my Judaism,” she tells me. She says “Abdul is not Hasan Piker, so I don’t conflate them”. I ask why Piker keeps coming up. “It gets weaponised. I don’t know if you watched the debate the other night, but talk about… weaponising fear and weaponising anxiety and all that Islamophobic dog-whistling that was coming towards Abdul.” I also talk to Elissa about how Americans more broadly appear to be questioning the US-Israel relationship and whether American Jews were ready to do that too. “A lot of American Jews are. My experience is absolutely the tide is turning.” For the first time, Gallup found this year that Americans now sympathise more with the Palestinians than the Israelis. In another poll of Jewish American voters, 65% said they were pro-Israel but also critical of Israeli government policies, 52% support cutting or eliminating aid to Israel. Father and daughter Back at the dinner table, I bring up those polls with David Fink. Why does he think Americans sympathise less with Israelis? [ ](https://channel4news.substack.com/p/how-support-for-israel-in-us-is-declining) [ How support for Israel in US is declining ](https://channel4news.substack.com/p/how-support-for-israel-in-us-is-declining) Kiran Moodley · May 4 [ Read full story ](https://channel4news.substack.com/p/how-support-for-israel-in-us-is-declining) “Because the news media and the extremes of both parties are so willing to tell what I think is a false narrative.” Lauren chimes in: “Do you really think the actions of Israel have nothing to do with the shift in the sympathies?” “I think that’s very relevant,” he replies. “I just don’t think that people really have a full understanding.” Lauren again: “It sounds like you’re saying that the shift is due to how the atrocities are being described, as opposed to what the actual atrocities are.” “There have been some things that shouldn’t have happened,” David says. “I think the polling is being driven by politicians who are taking advantage of this issue.” Lauren then asks, “I’m curious what your response would be if my children were killed in an Israeli airstrike and someone said there have been some things that shouldn’t have happened?” A long pause from her father. “Any reference to my grandchildren has a very deep emotional impact on me. Well done,” he says. “I have an empathy for any civilian in war and I don’t mean to belittle those losses. The loss of any one life is a horrible thing. But it doesn’t make it a war crime and it doesn’t make it genocide.” Lauren and David cannot agree but tell me how proud they are of one another for sticking to their convictions and for agreeing to let me sit in on their conversation. I cannot thank them enough for their time, and hope their honesty informs and educates many people during such a fraught election. Abdul El-Sayed: The candidate testing the US - Israel relationship Thanks for reading our latest FourSight newsletter. Subscribe to receive free weekly newsletters from Channel 4 News. Subscribe Share Channel 4 News Leave a comment
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A golden age of science is coming
It’s almost hard to remember, but just a few years ago, a lot of very smart people thought that science was in terminal decline. Respected researchers were writing papers with titles like “Are Ideas Getting Harder to Find?”, “Papers and patents are becoming less disruptive over time”, and “Slowed canonical progress in large fields of science”. In 1996, science writer John Horgan even published a book called The End Of Science: Facing The Limits Of Knowledge In The Twilight Of The Scientific Age. The fundamental idea was that the Universe only has so many insights to discover, and that we’ve picked the low-hanging fruit. It was the idea that Joseph-Louis Lagrange expressed when he said that “we cannot find more than once a system of the world to establish.” As the big ideas and the simple ideas get mined out, we’re forced to throw ever more brains at the mysteries of nature just to keep scientific progress going at a fraction of its old pace: It looked like science was hitting a wall. Then along came AI. It’s far too early to tell how much AI will eventually speed up the growth of total factor productivity. But already we can see signs of a speedup in science. Anthropic Founder Jack Clark assembled some of the hopeful data points in a recent lecture: [ Dror Poleg@drorpoleg "If you pick different parts of science, you see the same pattern show up: Progress is accelerating, and it has started to accelerate in the last two years." Jack Clark @jackclarkSF I’m speaking at the IMF in an hour about the singularity and why I believe it has begun and the choices we'll need to make. Watch live here: https://t.co/Hj9HzcXx5h 6:08 PM · Oct 18, 2026 · 21.2K Views 2 Replies · 10 Reposts · 123 Likes ](https://x.com/drorpoleg/status/2111882070376980529) Anthropic is accelerating its investment into drug discovery, and is already announcing some impressive preliminary results: [ BioTender@Junioryu136689 BREAKING: Anthropic unveils early results from six Claude-powered drug development collaborations. • 70% shorter CAR-T signaling domain • ~35,000 antibody designs • >10× tighter antibody binding • 89% less batch-record review time Still largely preclinical. Anthropic @AnthropicAI Over the past few months, Anthropic scientists have engaged in deep research partnerships with six organizations developing new medicines. We've also begun drug discovery efforts of our own. In doing so, we’ve learned much more about how Claude can support the many stages of 9:43 PM · Oct 27, 2026 · 11.2K Views 3 Replies · 24 Reposts · 205 Likes ](https://x.com/Junioryu136689/status/2115197821150495150) Claude also appears to be enabling rapid progress toward a treatment for food allergies. OpenAI, meanwhile, announced a possible breakthrough treatment for neurodegenerative disease. Meanwhile, Google Cloud Chief Scientist Pushmeet Kohli has a list of recent scientific advances that have been enabled by its new Gemini model, including breakthroughs in nuclear fusion reactor design, rare disease research, and quantum computing: [ Pushmeet Kohli@pushmeet Gemini 4 Argon is a step change in model performance. In recent weeks, it has had a transformative impact on the Science projects in our team at @GoogleDeepMind and our external collaborators, and helped make a number of remarkable advances across scientific disciplines. 🧵👇 4:47 PM · Oct 13, 2026 · 36.5K Views 8 Replies · 41 Reposts · 497 Likes ](https://x.com/pushmeet/status/2110049807385702623) But as cool as these stories sound, they’re just very minor, preliminary efforts. There are a number of reasons to think that AI is going to propel us into a golden age of scientific discovery. That age might not last forever — AI might still run into diminishing returns eventually. But the next few decades are probably going to be an absolutely amazing time for human science. The number of “effective researchers” is no longer limited The most important input into science is scientists themselves. Until this year, that meant human brains — talented, highly trained human brains. The number of trained human brains could be increased by sending more people to grad school, but only to a point — the smartest people tend to be sent into the hardest research fields first, and if you 10x the number of researchers, the average quality will go down. This constraint was already starting to bite, as Ekerdt and Wu argued in 2024: We argue that a substantial portion of the downward historical trend in U.S. research productivity is a composition effect resulting from self-selection in researcher ability and the dramatic expansion of the research sector…[W]e find that this composition effect has lowered average researcher ability by between 37% and 53%[.] And of course, low fertility was making the problem worse, because fewer children meant fewer people who were able to become future scientists. AI just blows up this constraint completely. If an AI agent can function as an autonomous researcher, there’s no constraint on the number of researchers in the world — you can just build more of them, by building more computer chips and data centers that enable the running of more AI agents. Whether or not massive hordes of agents can collaborate to solve individual problems much faster, increasing the number of agents allows them to tackle many different research questions in parallel. What’s more, these AI “researchers” can be trained incredibly quickly compared to human beings. A human scientist takes decades to train, and more years to reach the frontier of their research field by diligent reading and conversation. This is the “burden of knowledge”, and it’s commonly believed to be one reason ideas have been getting harder to find — by the time human scientists can get up to speed, they’re often so old that their ideas are no longer novel. AI just annihilates this constraint — it can assimilate the entire literature and reach the frontier of research extremely quickly, and it can also tell human scientists where the frontier lies without forcing them to discover that for themselves. It can also pivot to new research directions more easily than humans can. And there’s also a self-reinforcing economic cycle here. Because scientific advances enable higher GDP, they enable more resources to be invested into the creation of yet more electronic “scientists”. Now that doesn’t mean the amount of scientific research goes to infinity — there may still be some essential bottleneck task that human researchers are still needed to perform. There are some indications that AI’s progress on open-ended conceptual research tasks is slower than in other dimensions, and it may be that humans are still needed to provide some of this long-term conceptual thinking. I’d bet against this being true for much longer, but it might be true for a long time. Even in this most “pessimistic” case, though, the amount of effective capital that scientists can use to leverage their work just went up by a lot. AI eliminates the theory bottleneck Science proceeds by an iterative process of theory and experiment. The theory part of that cycle is typically short, but non-trivial — it took a couple of years after the blackbody radiation spectrum was observed for Max Planck to come up with the quantum hypothesis to explain it, and decades longer before quantum theory as we now know it was created. It took about a year for Watson and Crick to figure out the shape of DNA after the requisite data was gathered. AI will basically eliminate the theory bottleneck entirely — or at least shorten the turnaround time between experiment and theory by an order of magnitude. AI is an absolute beast at math. Recently, an OpenAI model solved some of the most important open problems in computer science, math, and theoretical physics, and no one even batted an eyebrow because that sort of triumph is becoming increasingly commonplace. One of those solutions was a proof that the Standard Model of Particle Physics could be mathematically well-defined — a problem that human theorists had so far been unable to tackle. Not all research relies equally on theory, but understanding novel experimental results almost always involves some important component of either mathematical or spatial reasoning. That part of the task has now been made much, much faster. And on top of that, science is now open to a greater number of humans who aren’t naturally good at theorizing. AI can read the whole literature Much of the work of human scientists involves reading and understanding endless amounts of papers and going to endless conferences and seminars. The purpose of that work is to understand the existing scientific literature. Understanding the literature allows scientists to do the following things: Come up with new ideas for hypotheses to test Avoid doing research that someone else has already done Synthesize approaches from different areas or fields AI can reduce this effort to almost zero. Consider this excerpt from OpenAI’s blog post about their new research into neurodegenerative disease: The team divided the analysis among thousands of AI agents powered by GPT‑Rosalind, an approach we call distributed biological reasoning. The agents examined a whole-brain CRISPR atlas…a dataset showing how gene disruptions affect different types of cells across the mouse brain. Each agent investigated a gene disruption, analyzed cellular responses, searched scientific literature, and proposed explanations for the results. Their reports were combined into a reasoning atlas linking genes, cellular effects, relevant publications, and possible biological mechanisms. The research team estimated that comparable human analysis and literature review, conducted one perturbation at a time, would take months to a year. The agents reproduced findings from human analyses while uncovering additional leads. Their assessments of novelty and scientific value also aligned with judgments from blinded human experts. These findings help prioritize further experiments needed to test the proposed biological mechanisms. Some of these insights point to new leads for understanding brain disease. [emphasis mine] This is one case in which parallel work by a large number of agents really does make a huge difference: [ Haider.@haider1 this is actually insane openai deployed thousands of GPT-Rosalind agents to analyze millions of mouse brain cells in 32 minutes, work that could take human researchers months to a year also the agents uncovered new leads for brain diseases like Alzheimer's and Parkinson's OpenAI @OpenAI GPT-Rosalind surfaced a new lead for drug discovery: could restoring cholesterol transport protect neurons from degeneration? DCTN1 is a gene linked to Perry syndrome, a rare neurodegenerative disorder. In mouse-brain data, disrupting it increased expression of genes involved in 2:41 PM · Oct 21, 2026 · 51.5K Views 26 Replies · 95 Reposts · 1.26K Likes ](https://x.com/haider1/status/2112917197903540516) Not only does instantaneous literature review vastly speed up the research process, but it allows AI to make novel conceptual leaps from combining approaches from wildly different fields of research. AI regularly does this in math research, combining results, approaches, and theorems from far-flung places that no human mathematician would have thought to combine. It can do it in science, too. Much of scientific innovation, historically, has been “recombinant” innovation — scientists applying insights from one field to another. With AI, essentially all research is now cross-disciplinary — AI can read not just the literature on a particular subject, but the literature on a million other subjects that might have produced useful techniques or insights for the problem at hand. Superscience So far, all of the factors I’ve listed are ways that AI can speed up science as it’s already done. I’ve basically described how AI can send gigantic hordes of superhumanly fast, superhumanly well-read, superhumanly mathematically gifted researchers to re-accelerate scientific discovery. But it’s also possible that AI will enable types of discovery — and ways of understanding the natural world — that no network of humans, no matter how large or how brilliant it was or how long it had to work, would ever be able to discover. In a post back in July, I wrote about how that might work: What if there are lots of…aspects of the Universe that [are] too complex to understand in terms of simple laws, but not so complex that they just dissolve into unknowable chaos? It’s possible that we can reliably control these complex phenomena with AI, even if we never reduce them to the kind of principles that we can teach a grad student in a textbook… Another way of saying this is that there may be laws of the universe that humans can’t understand but AI can. I call these “cloud laws” — causal regularities that can be exploited by technology, but which are too diffuse and complex for an individual human being to either intuit or communicate… Perhaps social sciences like economics, sociology, and political science obey similarly complex regularities, and AI can help us find them. Perhaps there are physical processes — plasma, or topological materials, or aerial turbulence, etc. — that obey cloud laws instead of chaos?… [H]uman collaboration is bottlenecked — it’s limited by our ability to intuit patterns at an individual level, and to communicate these patterns from one individual to another. AI, being a computer, just doesn’t have this sort of limitation; it can work with vast, diffuse patterns without having to break them into pieces or simplify them in order to compress them into the tiny pipelines of person-to-person explanation… If much of the Universe turns out to be ruled by cloud laws, we could be on the precipice of a scientific renaissance. In order to discover cloud laws, AI will need huge amounts of data about the natural world. AI figured out human speech by assimilating essentially all of the text humans have ever written. If it’s going to figure out hidden patterns in biology, neuroscience, materials science, etc., it’s going to need similarly massive amounts of data from physical instruments. That data will be far, far more than humans — individually or collectively — would be able to parse, label, characterize, or model. But AI was built to do this. If scientists simply build huge arrays of sensors to measure complex phenomena like the brain, the cell, the economy, etc., they may be able to feed this flood of data to AI directly and bypass human cognitive intermediation entirely. AI would then learn about the world directly, and it might learn things that humans never could. This “superscience”, if you want to call it that, would actually go beyond the kind of science humans have done heretofore. Many of the technologies it yielded would be beyond human comprehension — indistinguishable from magic. But to the AIs, they would make perfect scientific sense. In any case, it seems clear that the scientific slowdown that threatened human progress will now be delayed — at least for a while. Unless humans have somehow found most of the actual exploitable regularities in our Universe, we’re about to enter a new golden age of science. Subscribe Share
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