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Burglars ransack 5 businesses across 4 Chicago neighborhoods within 3 hours, police say
Police issued a warning about business burglaries on Chicago's South and Southwest sides.
Sunset Buzz: In a world of AI, Jay Pham says, consider an Irish sports bar
The Four Deuces, 2319 Taraval Street, has anchored the neighborhood for decades. The latest chapter comes with a change in ownership.
Crossroads District businesses react to Royals stadium proposal near their neighborhood
Local business owners in the Crossroads District reacted to the city's new Royals stadium proposal two years after voters denied a sales tax extension for a downtown baseball stadium.
Aviatra Accelerators to host Women-Owned Business Crawl April 25 in Covington
Aviatra Accelerators will showcase a new retail marketplace during its Women-Owned Business Crawl in downtown Covington and MainStrasse neighborhoods on Saturday, April 25, from 11 a.m. to 4 p.m. The event will feature more than thirty women-owned businesses – from retail shops to bars, restaurants, and service providers – across Covington’s thriving small business community,...
Sacramento crematorium plan faces scrutiny as neighbors raise health concerns
St. Denis neighbors push back against business applying for liquor license
Less liquor stores and more community resources: that’s what residents of the St. Denis neighborhood are hoping for as they push back against a business applying for a liquor license.
Olivia Munn Says 'Obnoxious' Male Co-Star Wouldn't Let Her 'Save' Him On-Screen
The “Your Friends & Neighbors” star said the actor quickly grew “combative with the director” over the scene.
Ishbia family taking swing at youth sports facility for vacant Office Depot
(Editor’s Note: Alex Harrison Perry reported this story for Evanston RoundTable, a neighboring independent newsroom. It was shared with The Record as part of an ongoing collaborative effort.) The vacant Office Depot building at 2722 Green Bay Road — just a block south of Wilmette — could become a year-round site for youth sports, as a North Shore family […]
Detroit hiring retail director to boost stores in neighborhood business districts
Jeffrey Lewis II opened Morningside Cafe on Detroit’s east side three years ago and said he has seen growing momentum along East Warren Avenue.
Businesses in Rochester's EMMA, Beechwood neighborhoods to receive grant funding
Through KeyBank's Small Business Fund, local businesses can apply for grants from $2,500 to $10,000.
Washington State Ousted This Health Insurance Lookalike. In Oregon, It Carries On.
From one vantage, the story of Zion HealthShare shows Washington to be an overzealous nanny state. From another perspective, Oregon might stand to learn from its consumer-protection-minded neighbor to the north.
Business in Brief: New Van Ness businesses; Intelsat auction canceled; Whale Tea rebrands; I’m Eddie Cano bankruptcy update | Forest Hills Connection | News and Life in Our DC Neighborhood
Some Forest Hills Connection reporting involves poking our heads through open doors. Doing so recently yielded the news that the last remaining vacant retail space at Park Van Ness (4455 Connecticut Avenue) has been leased to an IV hydration spa. A contractor getting the space ready told us Hydralive Therapy is moving in. Similarly, we […]
‘Neighbors’ finds entertainment in the mundane
For fans of reality TV, a new series has entered the world of streaming services. “Neighbors,” an American television series, was released on Feb. 13. Directed by Harrison Fishman and Dylan Redford, “Neighbors” aims to bring out the world’s craziness by showcasing real-life conflicts over mundane topics between various neighbors and neighborhoods. At the moment,...
Let Colorado’s communities govern their own neighborhoods
By Jeff Bailey and Cindy Bailey Coloradans have always done things their own way. From how we manage our land to how we build our economies, the instinct to govern locally — to trust mayors, councils and commissioners over distant bureaucracies — is not a partisan position. It is a point of pride. When a […]
Eligibility questions spark calls to suspend Minnesota’s $100 million ‘promise’ to small businesses
5 INVESTIGATES found several Minnesota Promise grant recipients appear to be operating miles outside of eligible neighborhoods, and others that may not be operating at all.
Health care costs are Americans' top worry, a new poll finds
A new Gallup poll reveals health care access and affordability is Americans' top concern, surpassing the economy and inflation.
VHC Health development plan faces pushback at environmental meeting
A proposal for a new behavioral health center on S. Carlin Springs Road is facing pushback on environmental impacts and effects on the surrounding neighborhood. Misgivings about the 146-bed, 131,000-square-foot development proposal from VHC Health and Lifepoint Health made their way into discussions at the March 26 meeting of the county's Forestry & Natural Resources
‘Soaked and broken’: Owner of Enfoque Images devastated after her business building collapses
GEDDES, N.Y. (WSYR-TV) — What was once a photography building has now partially collapsed. For Jacqueline Vidler, owner of Enfoque Images, when a neighbor calls, it’s usually not a good sign. “He said...
What now? State study weighs health impacts of Republic Steel in Canton
A new state study examines Canton Republic Steel's potential health effects on the community. Neighbors remain uncertain.
Houston East End underpass floods again, drivers stranded and businesses impacted
A flood-prone underpass in Houston’s East End is once again causing problems for drivers and businesses, with neighbors saying even light rain can make the road impassable.
Chicago travel mistakes I made as a first-time tourist
I spent two days in Chicago for the first time. I regretted exploring too many neighborhoods and visiting in the winter.
Austin home-based business rules could change under new pilot program
Austin is considering a pilot program to allow more home-based and “front yard” businesses, aiming to lower startup costs and help residents launch small ventures within their neighborhoods.
Austin weighs allowing front-yard businesses to help residents launch dreams from home
Austin is considering a pilot program to allow more home-based and “front yard” businesses, aiming to lower startup costs and help residents launch small ventures within their neighborhoods.
City of Gadsden breaks ground on Phase 5 of improving Gadsden Sports Park
Gadsden Mayor Craig Ford says he grew up in the neighborhood and is proud to see the facility where it is today.
Protect Los Santos and Acquire New Law Enforcement Vehicles During the Latest Neighborhood Watch Event
Clean up the streets and assist residents across Los Santos and Blaine County during the new Neighborhood Watch Event in GTA Online.
ArchWell Health opens 4 new senior care clinics in Northeast Ohio
The Medicare Advantage-focused health provider will host grand openings throughout April in Cleveland Heights, Euclid and two Cleveland neighborhoods, bringing its regional total to nine centers.
Iran fires missiles at Israel and Gulf neighbors as Trump talks of winding down Mideast war
Iran responded to U.S. President Donald Trump’s address to Americans on the war with new missile attacks targeting Israel and the Gulf Arab states
Yet another San Antonio business shutters in rapidly evolving part of town
The neighborhood's food and drink scene is in flux.
Firing Cop in Shooting, Did Mayor Yield to Politics?
When he peremptorily fired the Hartford police officer who shot and killed a mentally ill man who was walking through his neighborhood with a long knife and was refusing police […]
Walkable Neighborhoods Can Boost Physical Activity, Population Health
New research from Washington State University shows that small increases in neighborhood walkability could lead to substantial gains for a sedentary population, boosting individuals’ physical activity and ultimately improving their health.
The art of small-town politics
When we arrived in River Forest, the village board was dominated by a village president who had reigned from 1993-2009. An interregnum of four years ensued, followed by the current board president, in place since 2013. Ours is a small town next to a large town. River Forest has about 12,000 residents. Our neighbor to […]
Kansas City business owners oppose single-serve alcohol ban
Business owners are fighting back against a proposed ordinance that would ban single-serve alcohol sales in high-crime neighborhoods.
Neighboring businesses react to possible arson after Petersburg house fire
An arson investigation is underway after a large house fire in Petersburg Sunday afternoon.
Haleiwa open for business as North Shore storm recovery continues
While people are urged to stay away from impacted neighborhoods, local business leaders stressed that Haleiwa town is open and that respectful support can help the community recover.
As Trump Squeezes Cuba, U.S. Military Exists in a Bubble
The Navy base at Guantánamo Bay sparkles at night while neighbors across a Cuban minefield struggle in darkness driven by a Trump fuel embargo.
Silencer Central acquires vacant Wells Fargo building for future growth
A former Wells Fargo call center is off the market -- bought by its neighboring business for future growth.
Pitt commits $5M in new investments to city parks, neighborhood business corridors and public safety
The University’s most recent commitment builds on decades of collaboration and support between the City of Pittsburgh and its premier anchor institution.
Do good neighbors make good economies? Minnesota could be a test case
Economic studies strongly suggest that higher levels of trust can lead to increased commerce, promote financial innovation and even foster economic growth. Will the neighborly care and civic engagement in Minnesota during the Immigration and Customs Enforcement surge translate into economic resilience?
BUSINESS MONDAY: Spotlight on the NinjaFit Playground by Neighborhood Ninjas—coming to Lee this summer
Providing a “fun, free, safe and accessible space where community members of all ages can connect and engage in free, obstacle-based fitness and active lifestyles together.”
Hingham Schools Eye Business Curriculum Expansion as Class Size Concerns Mount
HINGHAM - March 23, 2026 - The Hingham School Committee moved to modernize its high school offerings Monday night, reviewing a comprehensive plan to expand the “small but mighty” Business Department while simultaneously grappling with data that places Hingham as an outlier in elementary class sizes. Director of Social Studies Andy Hoey presented a two-year program review that highlighted the department’s success in community partnerships but warned that high student demand is testing current staffing limits. Meanwhile, committee Chair Jen Benham presented independent research showing Hingham is the only benchmark district with second-grade classes hitting a 25-student cap, sparking a directive for the Policy Subcommittee to review class-size standards. Editors note: South Shore News is going paid in April, subscribe now to make sure you don’t miss a story. Reach out for group or organizational pricing. Subscribe The Full Story The meeting opened with a look into the future of Hingham High School’s (HHS) curriculum. Andy Hoey, who oversees the Business Department, presented the first formal program review for the department since 2009. [15:09] Hoey characterized the department as a vital elective hub that currently serves between 14% and 27% of the HHS student body in any given year. [31:31] “We are very proud of our business department here at Hingham High School... while we’re very proud of it, we are always striving to make improvements and enhancements.” [15:55] — Andy Hoey, Director of Social Studies A key highlight of the presentation was the announcement of a new AP Business with Personal Finance course launching next year, pending enrollment. [20:08] The review team found that while the program is “well-aligned” to national standards, it remains a high-school-only offering. Hoey outlined an action plan to explore “vertical articulation,” potentially introducing business or financial literacy units at the middle school level to fill a “gap” identified between fifth and eighth grade. [41:48] However, the department faces “smoke and mirrors” regarding student GPA, according to Hoey. Currently, most business courses are “unleveled” and do not count toward a student’s GPA, which survey data suggests may deter some students from enrolling. [28:15] The committee discussed the possibility of offering Honors or College Prep (CP) credit for advanced courses, such as investing or marketing, to better reflect their academic rigor. [38:27] The discussion took a sharp turn toward elementary education during an enrollment update. Superintendent Dr. Katie Roberts noted a net gain of four students mid-year, but it was Jen Benham’s “rabbit hole” data analysis that caught the committee’s attention. [50:35] Benham researched 13 benchmark towns—representing 34 elementary schools—and found that Hingham was the only district with a second-grade section reaching 25 students this year. [51:36] Benham’s findings suggested that while many districts lack formal class-size policies, Hingham’s current cap of 25 for second grade may be too high. “I think if we could at least have 23 at a cap for grade two,” Benham suggested, noting the importance of that grade level for literacy development. [53:09], [54:55] Dr. Roberts cautioned that smaller classes require more staff, which is a significant hurdle following a budget season where nine general education positions were cut across the district. [55:56] The committee also finalized the 2025 Town Report, which was updated to be more “student-centered” and highlight staff early in the document. [11:12] Additionally, a series of food service policies were approved to align with Massachusetts’ universal free school meal mandate, including new protocols for meal modifications due to allergies or religious needs. [59:23] Share Why It Matters The meeting underscored a tension between Hingham’s desire to offer elite, specialized programming and the foundational pressure of class sizes. The expansion of the Business Department—including potential Microsoft certifications and AP courses—aims to prepare students for a “real world” where credit scores and financial literacy are paramount. [46:20] However, the revelation that Hingham’s second-grade classes are larger than those in all neighboring benchmark towns suggests a potential strain on early education that could impact long-term student performance if not addressed by the Policy Subcommittee. Official Minutes & Data Key Motions & Votes Motion: To approve the Hingham Public Schools 2025 Town Report. [13:16] Vote: Unanimous (7-0) ([01:13:28]) Motion: To approve the Memorandum of Agreement (MOA) for summer counselor work regarding course placement. [57:33] Vote: Unanimous (7-0) ([57:50]) Motion: To approve Policy EFBA (School Food and Nutrition/Meal Modifications). [01:00:32] Vote: Unanimous (7-0) ([01:00:44]) Motion: To approve Policy EFC (Universal Free School Meals). [01:00:54] Vote: Unanimous (7-0) ([01:01:07]) Public Comment No members of the public spoke during the meeting or via the remote link. [01:02:30] What’s Next The Policy Subcommittee will take up the review of elementary class-size caps over the next year to determine if the Grade 2 limit should be lowered from 25 to 23. [52:18] The Business Department will monitor enrollment for the new AP Business course and continue exploring dual-enrollment partnerships with Quincy College. [38:13] Source Video: Harbor Media South Shore News is a reader-supported publication. To receive new posts and support my work, consider becoming a free or paid subscriber. Subscribe
Arizona fans pack Arcadia sports bar to watch Wildcats advance
Arizona fans filled a popular UofA sports bar in Phoenix's Arcadia neighborhood to cheer on their Wildcats.
Why a retired Army officer sees Michigan as key to defense industry
Lt. Col. Misty Martin (Ret.), who is chair of an upcoming defense expo in Detroit, says 'every neighborhood in Michigan has someone who served.'
Broad Ripple welcomes new sports, entertainment venue
BROAD RIPPLE, Ind. — The Broad Ripple neighborhood will soon be home to another place where people can enjoy fun and food. Stick & Hack Entertainment is opening its second location at 46th Stre…
Lithia sports facility proposal sparks heated zoning battle between neighbors, supporters
A growing dispute is unfolding in Lithia, where a proposed private youth sports complex is drawing strong reactions from both neighbors and supporters.
The Family Van brings free health screenings to Boston neighborhoods
With barriers rising in health care access, mobile clinic fills critical gaps
Linden Entertainment Signs ‘Your Friends & Neighbors’, ‘Tow’ Director Stephanie Laing
EXCLUSIVE: Linden Entertainment has signed Emmy-winning director, writer, and producer Stephanie Laing for management. Laing is coming off the theatrical release of her new film, Tow, a comedy-drama s...
Your Thymus and Your Healthspan
Our thymus gland plays a central role in the development or our immune system, specifically for supporting T cell development (how these cells got their name, maturation and differentiation in the thymus) and discriminating between self and foreign, non-self antigen proteins with production of dendritic cells. As we age, our thymus gland shrinks—the process known as involution—with progressive change from spongy to fatty tissue, with loss of functionality. But this process, with respect to timeline and extent, markedly varies from one person to the next. And to make things even more complicated, our thymus gland anatomy and precise location in the chest also is highly variable. So the famous Frank Netter diagrams from the 1960s (such as at left below) don’t capture the remarkable heterogeneity that a random set of 12 chest CT scans (below at right). What I consider as 2 landmark papers in Nature this week (here and here) used AI to quantify health of the thymus in 2 large cohorts, and then correlate the metric to a broad array of health outcomes. In this edition of Ground Truths, I’m going to cover three questions: (1) How was thymus health determined by AI?; (2) How is thymus health linked to key clinical outcomes? and (3) Are there ways we can promote a healthy (aka rejuvenate) thymus gland in our later years? Subscribe 1. How was thymus health determined by AI? This was accomplished by extensive work developing and validating an AI pipeline for 2 stages, the first for localization and segmentation of the thymus bed, and the second to quantify a digital marker, termed the thymic health score. There’s a lot to this algorithmic development, so I won’t go into all the details, but just provide a rudimentary outline of what was done. The 1st stage used supervised learning with 2 radiologists reviewing 2,461 chest CT scans. That work trained a 3D U-Net model to automatically identify the thymic bed’s 3D cropped region using center of mass coordinates, which reached 99.8% accuracy. The 2nd stage used a foundation model that was pre-trained with SwAV (which stands for Swapping Assignment between multiple Views), a self-supervised model, that generated a high-dimensional thymus representation of 4,096 features. That compares to the radiology reductionist and subjective scoring of 0 to 3 where 0 means the thymus is fully degenerated and fatty, and 3 is considered dense, intact glandular soft tissue. Notably, the self-supervised learning (SSL) performance was superior to supervised (AUC ~0.75 vs 0.55, respectively) reflecting the shallowness of the 0-3 classifier vs SSL’s holistic, self-taught AI. The thymic health score ranged from 0 to 100, with the highest number indexed to fully preserved thymic health. The algorithmic work extended to explainability with both Shapely value distribution, meaning the model was holistic not relying on any “magic” pixel, and occlusion sensitivity, demonstrating the model’s performance was not affected by ribs, sternum, lung tissue, but rather focused on the thymic bed directly. Below are a few saliency maps from the occlusion sensitivity that indicate the thymic bed focus, not affected by neighboring structures, using the jet color scale. Now the AI was ready for processing ~25,000 CT scans, each over 30 MB files, from the 2 large participant cohorts to provide a thymic health score, it did so in less than 14 hours, which is less than 2 seconds per scan! Share 2. How is thymus health linked to key clinical outcomes? The two cohorts were the National Lung Screening Trial, NLST (N=25,031) and the Framingham Heart Study, FHS (N=2,581) each with baseline demographics and long term follow up of >12 years for health outcomes. From the NSLT, you can see below that increased age and body-mass index were correlated to reduced thymic health. And, overall, men had reduced thymic health scores compared with women. There are a lot of graphs in the paper for outcomes, for both the NLST and FHS cohorts. To simplify the major outcomes, below is a composite Figure with striking reduction of all-cause mortality and for the different causes of death. The results were consistent between the 2 cohorts. For example, the cardiovascular mortality hazard ratio average was 0.57 in NLST and 0.38 in FHS (weighted to be 0.53 for the aggregate). The reduction of mortality also extended to digestive diseases and pulmonary disease (data not shown below). Lung cancer incidence was reduced by 36% for high vs low thymic health (Figure below, with a panel -incidence and b panel-mortality, adjusted for age, sex, BMI, smoking status). Notably, there was a smoker’s paradox: lower incidence and improved survival for lung cancer in smokers who had a high thymus health score. Smoking was associated with lower thymic scores whereas alcohol was not. Higher thymic health was linked to higher HDL cholesterol, lower triglycerides, lower fasting blood glucose, and lower systolic and diastolic blood pressure. Inflammation biomarkers, such as C-reactive protein and interleukin-6, were elevated in the people with lower thymic health scores. In their second paper, the same team looked at the relationship between thymic score and outcomes for 3,476 patients receiving cancer immunotherapy. The non-small cell lung cancer progression-free survival was reduced in patients with low thymic health score. A parallel relationship for survival was seen for other types of cancer including melanoma, breast, and kidney with a 44% lower risk among high thymic scores (Figure). A similar pattern was seen with different immune checkpoint inhibitors. The thymus health score outperformed programmed death ligand-1 (PD-L1)and tumor mutation burden (TMB) assay of the tumor and was an independent prognostic marker of progression-free survival. In this dataset, a direct connect with thymus score and adaptive immune function was noted with a correlation before cancer treatment for both T-cell diversity and thymus T-cell production (a metric known as T cell receptor excision circles). Thymus Removal Study There is a highly relevant citation about thymus function before moving onto ways to rejuvenate it. In 2023, a very important study of thymus removal during cardiothoracic surgery was published, with 1146 patients undergoing thymus removal vs 1146 matched controls (mean age 55 years). The adverse outcomes for thymus removal were striking, with a 2.9 higher risk of all-cause mortality and doubling of cancer incidence, 1.5 fold increase in cancer mortality, and 1.5-fold increase in autoimmune diseases. The immune function showed marked compromise after thymus removal, as reflected by CD4+ and CD8+ T cells (Figure below) Share Ground Truths 3. Are there ways we can promote a healthy (aka rejuvenate) thymus gland in our later years? In recent months we’ve learned a lot about the process of thymus involution and the pathways by which this may be modulated. Thymus involution is primarily due to loss to thymus epithelial cells (TECs) and there are 2 subtypes with different functions: the cortical, responsible for positive selection of T cells, and the medullary, for negative selection. When adipose tissue infiltrates the thymus, thymic adipocytes are pro-inflammatory, knocking out T-cell output. Likewise, systemic inflammation, or “inflammaging,” from smoking, obesity, and chronic stress promote thymic adipocytes. Now, from preclinical studies, we know about key pathways that account for these processes. Historically, back in 2014, FOXN1 was recognized as a single master transcription factor essential for TEC function, with studies in mice with forced FOXN1 upregulation leading to thymus regeneration. That laid the foundation for potential regrowth of quiescent thymus cells. It took awhile to find pathways to accomplish this goal and to even refute its role as the master regulator. The Liver-Thymus Axis Feng Zhang and his team recently showed that injection of an mRNA vaccine to the liver encoding DLL1, IL-7 and FLT3-L in combination, factors known to support thymopoiesis (Figure), successfully enhanced immune function in aged mice. However, the effect was transient. The FGF21 Story Two reports in 2025 addressed the thymus gland’s production of FGF21, a growth factor (fibroblast growth factor 21) and its control of thymus involution. This growth factor is also produced by the liver, but it doesn’t have impact on the thymus in aged rodent models. In contrast, The liver’s hepatocyte growth factor (HGF) has been shown to reverse senescent TEC structural changes. Growth hormone stimulates production of insulin growth factor-1 (IGF-1) in the liver and the thymus. Two small studies in human participants (TRIIM, for Thymus Regeneration, Immunorestoration, and Insulin Mitigation) of 6 and 50 people, respectively, treated with combined human growth hormone, metformin and DHEA, suggested the potential of slowing epigenetic aging and improving thymus mass and function. But the combination of drugs, small sample, and lack of controls make conclusions murky. Increased thymus FGF21 led to increased CD8 T cells in old mice and extended healthspan and improved physical performance. Building on the previous FOXN1 data, ablation of β-klotho, the obligatory co-receptor for FOXN1, accelerated thymic aging. The benefit to FGF21 was confirmed in a companion paper using an FGF21 knock-in mouse model showing thymus enlargement and increased TECs throughout the lifespan. (schematic Figure below). The accompanying editorial for these 2 papers speculated: “The proposed link between age-associated thymus involution and organismal aging is intriguing, and suggests we might seek to achieve systemic rejuvenation by counteracting thymic involution.” Other Factors Lessons from the Axolotl (Mexican Salamander) In an elegant set of experiments of the axolotl (Figure), known for its complete thymus regeneration after total surgical removal, mediators were identified. Surprisingly FOXN1 was dispensable. But midkine, a growth factor, appeared to be the driver, the initiator of thymus cell growth, survival, and repair. Other components that contributed were Postn+ (periostin-expressing mesenchymal niches) and Ccl19, a chemokine protein from the bloodstream. RANK and RANKL RANK (receptor activator of nuclear factor κB its ligand (RANKL) have been considered key regulators of medullary TECs. In a study of both aged mice and human thymus cell cultures, their key role was confirmed, with multiple benefits of resorting TEC function, recruitment of progenitor cells, and T cell development. Subscribe Summing Up This body of work strongly supports the health of the thymus gland as a critical regulator of human healthspan, not just a correlate or link. The new landmark studies are reinforced by the regenerative biology experimental models that have shown, via an array of mediators, that healthspan of aged mice is at least in part dependent on thymus gland function and its critical role for maintaining adaptive immunity. It sure seems that we’d be better off having an immune reservoir of naive T cells instead of a profile in older adults of exhausted, low quality, memory T cells, with a senescent phenotype. It is striking that we ignored the importance of the thymus gland for many decades. A wake-up call was the results of the thymectomy matched control study reviewed here, with the opposite of high thymic health score improved health outcomes. The convergence of AI and healthspan here is notable. The exceptional and laborious work for developing and validating (no less explaining) the AI to quantify thymus health set the foundation for probing the connect the major health outcomes in two cohorts with extensive follow-up. We’ve never had a way to meaningfully quantify the thymus gland before, so this represents important leverage of supervised, self-supervised, and transformer models. The study wouldn’t have been possible without AI. And it begs the question as to whether there are ways we can maintain our thymus at a high health score. But it’s not so simple to rejuvenate our thymus. There are multiple risks including the induction of autoimmunity, increasing the risk of cancer, and inducing a pro-inflammatory state. For example, factors that increase TEC proliferation could compromise the medulllary negative selection process and leak out auto-reactive (self-attacking) T cells. Thymic cells could be induced to proliferate, but we know, for example, that growth hormone and IGF-1 are associated with an increase risk of cancer. If thymus rejuvenation doesn’t clear out the accumulated senescent cells in older adults, then inflammation within the gland could block the production of TECs. Keeping these risks in mind, we now have identified many ways to keep our thymus healthy as we age that undoubtedly will be tested in clinical trials going forward. Ultimately, the benefit-to-risk tradeoffs will be defined. In the meantime, we have desperately needed an immunome. As I’ve stressed in multiple prior Ground Truths, we have no test in the clinic to assess a patient’s immune status! It was very encouraging for me to get an email from Hugo Aerts, the senior author of the landmark papers in the days after they were published: “I also wanted to say that your Substack on “Why We Need an Immunome” was inspiring for this work. We found it a very compelling perspective and greatly enjoyed reading it.” Just having an assessment of a person’s immune status via a chest CT scan, with millions of these performed per year, might help in guiding the right immunotherapy for cancer (e.g. more intensive, combinations for those with low thymic health scores) and help define people who are increased risk for age-related diseases of cancer, cardiovascular, and neurodegenerative. The main theme of Super Agers is that we now have many layers of data (genetics, proteins, biomarkers, organ clocks that can be integrated via multimodal AI) for us to define a person’s specific risk decades before one of these age-related diseases leads to symptoms, enabling prevention. From the new studies this week, we can add thymus health score as yet another way to understand a person’s risk, a window into their adaptive immune system and healthspan. And perhaps someday we will be able to safely rejuvenate the thymus, or maintain its health through one’s life, and use the thymus health score to monitor. NB: I wrote this post (No A.I.) A Quick Poll Loading... ********************************************************************* Thanks to Ground Truths subscribers (now > 200,000) from every US state and 212 countries. Your subscription to these free essays and podcasts makes my work in putting them together worthwhile. Please join! If you found this interesting PLEASE share it! Share Ground Truths Paid subscriptions are voluntary and all proceeds from them go to support Scripps Research. They do allow for posting comments and questions, which I do my best to respond to. Please don’t hesitate to post comments and give me feedback. Let me know topics that you would like to see covered. Leave a comment Many thanks to those who have contributed—they have greatly helped fund our summer internship programs for the past two years. It enabled us to accept and support 47 summer interns in 2025! We aim to accept even more of the several thousand who will apply for summer 2026.
Neighbors say Indian Springs revival could do KCK ‘more good than that stadium’
Area businesses said they want to see the project revitalize the State Avenue business corridor near I-635.
Something extremely weird is happening to our galactic neighbor. Scientists think they know why
The stars in the Small Magellanic Cloud aren’t behaving the way they should. A cataclysmic collision with another nearby galaxy may be the culprit
Nextdoor Promotes Tony Castellanos to Executive Vice President, People as AI-Driven People Strategy Becomes Core to Business Growth
SAN FRANCISCO, March 19, 2026--Nextdoor Holdings, Inc. (NYSE: NXDR), the essential neighborhood network, today announced the promotion of Tony Castellanos to Executive Vice President, People. Castellanos will lead Nextdoor's People organization — including talent acquisition, compensation, HR business partnering, and benefits — as the company deepens its investment in AI-enabled People operations and continues to scale its workforce strategy.
Dickens calls on business community to help tackle neighborhood disparities
In his State of the City address, the mayor urged businesses to "say yes" and help invest in underserved areas.
Cleveland business owner pushes back on illegal burning concerns after years of complaints
A Cleveland business owner is defending himself after neighbors raised concerns about suspected illegal burning on his property.The concerns first surfaced afte
5 Portland sports bars where you can watch every wild March Madness moment this year
From an early-bird option near the Moda Center to a neighborhood spot devoted to women's sports, these Portland bars offer full menus and multiple TVs for tournament viewing.
Koreatown rideshare driver arrested for allegedly using $2M in COVID business loans for crypto investment
A rideshare driver from Los Angeles’ Koreatown neighborhood has been arrested for allegedly using more than $2 million in fraudulently obtained COVID-19 pandemic business loans to buy cryptocurrenc…
After a decade in Titusville, this neighborhood restaurant now closed
Ice House Grill, a longtime restaurant along U.S. 1 in Titusville, has closed after 10 years in business at 2850 S. Washington Ave.
Paul Questions Mullin’s Character Over Response to Attack by Neighbor
Senator Rand Paul was assaulted in 2017. Markwayne Mullin acknowledged that he once said he understood the reason for the attack, but did not apologize.
At least 9 Sacramento businesses hit by overnight burglaries
Sacramento police are investigating at least nine overnight burglaries across Curtis Park and Lemon Hill neighborhoods, with surveillance footage capturing thieves in action.
Geffen Playhouse 2026-27 season: world and L.A. premieres
Geffen Playhouse Artistic Director Tarell Alvin McCraney aims to deliver 'world-class theater at your friendly neighborhood playhouse.'
Deadline Hollywood
CBS and Entertainment Tonight are saying goodbye to The Neighborhood with a farewell special. Read more below.
What's being built on Route 13 south of Smyrna, near Garrisons Lake?
A 9,100-square-foot building is under construction between Economy Inn and the Spring Meadow neighborhood.
U.S. completes historic hockey sweep in Olympics, Paralympics
Three weeks after the United States beat Canada in the Olympic hockey finals, the Americans overcame their neighbors again to win Paralympic gold and complete the three-peat at Milan Cortina.
Iran wages economic war in hopes of outlasting U.S. and Israel
Tehran warns of strikes on banks after hitting data centers, hotels, airports and seaports, threatening the global finance hub of its more prosperous neighbors.
As the risk of measles grows, why are parents so divided on vaccines?
In South Carolina, some parents embrace vaccines, others opt out. Why do people make such different choices? A mix of politics, distrust and misinformation is pushing neighbors apart.
Chapel Hill's South Creek Neighborhood Celebrates Construction Milestone, Announces First Business Tenant
The South Creek neighborhood's development team gathered for a ceremony recognizing the completion of its first full building structure.
Bucksport grocer who expanded business to neighboring counties dies at 73
Grocer Dale Tozier Sr., who expanded his family's grocery business in Maine, remembered as a community-focused family man.
The Neighborhood Politics of a Massive Home Addition
As municipalities encourage more housing density, neighbors debate what kind of construction should be allowed.
Business owners helping shape Hertel Avenue during Women’s History Month
BUFFALO, N.Y. (WIVB) — March is Women’s History Month, a time to recognize the contributions women have made in communities across the country. On Hertel Avenue in Buffalo, many of the neighborhood…
Cancer Haunts Neighbors of Canada’s Oil Sands Wastelands
Though high rates of the disease persist among the nearby Indigenous communities, the Canadian government is weighing rules that may allow energy giants to release treated mining waste into the river system.
Community chips in to help business damaged by building collapse
The building has sat empty since the 1980's, but over the weekend, part of the for 5 and 10 in Wellsville collapsed onto a neighboring business in the 400 block
Clermont’s plan to protect local businesses as Winter Garden loses them
Winter Garden's future is uncertain as several downtown buildings are being sold. Neighboring Clermont has a mission to stay local.
Reckoning With State and Federal Cuts, L.A. Safety-Net Clinics Push for a New Tax
By Bernard J. Wolfson | KFF Health News LOS ANGELES — Mia Angulo, who is pregnant and due in May, is living in a tent with her boyfriend in the predominantly Latino neighborhood of Boyle Heights. Lingering pain from a car crash two months ago, on top of an already hardscrabble life, has Angulo ...
As Obama Center nears debut, neighborhood poised for change
In the decade since plans for the Obama Center center were announced, here's how the area around it has changed — and how it hasn't.
Dulio: If faith calls for reflection, politics should too
There are often calls to “lower the temperature.” Real change is impossible until both our leaders and our neighbors accept that their side is part of the problem.
What's the big idea? If you've got it, World Business Chicago wants to know
The organization is calling for architects, designers, neighborhood groups, artists, innovators and interdisciplinary teams to submit visionary ideas that explore what Chicago could look like in 2050.
Sinkhole in Old City causing frustrating for neighbors and businesses
Massive sinkhole in Philadelphia's Old City neighborhood disrupts life for neighbors, businesses
Social Determinants of Health and Access to Orthopedic Care Among Seniors in Little Havana
Introduction: Little Havana, Miami, Florida, is a predominantly Hispanic neighborhood with many adults and seniors aged 65 and older at risk for osteoarthritis, osteoporosis, and associated frac...
A perfectly balanced atom just broke one of nuclear physics’ biggest rules
Physicists have discovered a surprising new “Island of Inversion” in a place no one expected: among nuclei where the number of protons equals the number of neutrons. For decades, these strange regions—where atomic nuclei abandon their usual orderly structure and become strongly deformed—were thought to exist only in highly neutron-rich isotopes far from stability. But experiments on molybdenum isotopes revealed that molybdenum-84 behaves dramatically differently from its close neighbor molybdenum-86, even though they differ by just two neutrons.
Astronomers discover giant cosmic sheet around the Milky Way
For decades, astronomers wondered why most nearby galaxies are speeding away from the Milky Way instead of being pulled in by its gravity. New simulations reveal the answer: our galaxy sits in a gigantic, flat sheet of matter surrounded by huge empty voids. This hidden structure—dominated by dark matter—balances gravitational forces and lets neighboring galaxies drift outward. The discovery finally explains the puzzling motions of galaxies just beyond our Local Group.
Overnight burglary spree hits six Chicago businesses
Chicago police are warning business owners after a string of overnight burglaries targeted six businesses across several South and Southwest Side neighborhoods.
Restaurant in 29 Palms says war in Iran has impacted its business
TWENTYNINE PALMS, Calif. (KESQ) – As the potential for an American ground invasion of Iran remains in question, uncertainty looms in the High Desert. The City of Twentynine Palms is closely intertwined with their Marine neighbors to the north, just five miles away from downtown. Among the people who live and work in the area,
USC student accused of Shandon stabbing released, receiving mental health care, attorney says
An 18-year-old University of South Carolina student accused of stabbing a man walking his dog in Columbia’s Shandon neighborhood has been released from jail and is receiving care at a mental health facility, according to his attorney.
AHA podcast: Advancing Community Health
Doug Brown, partner with Manatt Health and current chair of the AHA’s Foster G. McGaw Prize Committee, discusses how hospitals are tackling food insecurity, workforce development, safe neighborhoods and other social drivers of health through authentic community partnerships. Discover what it takes for hospitals to truly serve as cornerstones of their communities, and how the Foster G.
Buchanan Street residents split over business restrictions from zoning
Buchanan Street neighbors and business owners are weighing the pros and cons of applying a new zoning tool that limits certain types of businesses.
Duluth crews fight fire at Hillside neighborhood business
Duluth firefighters responded to a fire at Palisade Primary Care around 7 p.m. Tuesday evening.
See the entertainment lineup along the 2026 Los Angeles Marathon course
More than 26,000 participants will compete in the sold-out 2026 ASICS Los Angeles Marathon this Sunday along a course lined with lively entertainment. The marathon starts at 7 a.m. from Dodger Stadium. The finish line is at Santa Monica Boulevard and Avenue of the Stars in Century City. The 26.2-mile course goes through some of LA’s most recognizable neighborhoods and landmarks, including Elysian…
Black Political Caucus to file lawsuit to stop I-77 toll lanes
Residents in some historically Black communities say the I-77 widening will hurt their neighborhoods.
The First Fascist Was French, Antisemitic, and … Neighbors With Teddy Roosevelt?
Marquis de Morès had a wild life—and a short one. That’s probably for the best.
March in the Neighborhood: Timepieces and the science of time; Welcoming spring with cleanups and dance | Forest Hills Connection | News and Life in Our DC Neighborhood
Time, as we experience it, is a forward-moving phenomenon. For most of the past century, physicists have also understood time in that way, positing that “the first arrow of time” only increases disorder, or entropy, and there is no backtracking. That, however, does not explain how the complex systems of the universe are able to […]
Where billionaires are moving in Miami: Indian Creek, Coconut Grove
With Larry Page leading what one Miami broker called a "gold rush," these neighborhoods may soon be home to some of the world's richest.
Republican responds: neighbors before politics
To the editor, I read with great interest and compassion the recent letter from a neighbor, Emily Shapiro, who submitted “Is it too late to know thy neighbor?” in the Riverdale Press’s …
Old Town Albuquerque property owners weigh forming a Business Improvement District
Historic Old Town Association president J.J. Mancini says a BID — a mechanism through which property owners pool resources to fund services such as cleaning, maintenance, security and marketing — could take the historic neighborhood's goals and visions 'to the next level.'
Strikes on Iran upend some of the world's busiest airspace
Following US and Israeli strikes, Iran and neighbor nations closed airspace, impacting airlines like Qatar Airways and Emirates.
Vanderbilt Health Pets of the Day: Momo and Smokey
Today’s first Dog of the Day is Momo, submitted by Ginger DeBellis of the Vanderbilt Vaccine Center. “Momo is a sweet and super smart blue merle Australian shepard who loves learning new tricks, neighbor watching and snuggles.“ Today’s second Dog of the Day is Smokey, submitted by Haley Villacorta of Population Health. “Smokey is a Pomsky (Pomeranian and Siberian husky mix).” Pets of the Day — what you need to know The Vanderbilt Health Pets of the Day are included in regular editions of the MyVUMC News newsletter, which is posted twice a week by Vanderbilt Health News and Communications. The pets are selected from the hundreds of entries sent to the Voice Pet Photo Contest. For those who submitted a photo to that contest, watch MyVUMC News for Pets of the Day, and in addition, regular collections of pet photos are posted to the Voice site. You can see them all here: https://news.vumc.org/section/voice/pets-vumc/. If you have a pet you would like to nominate for Pet of the Day, the next Pet Photo Contest submission period is coming up later this year, and will be announced in MyVUMC News. Momo and Smokey were featured in the March 3, 2026, edition of MyVUMC News.
New AirSnitch attack breaks Wi-Fi encryption in homes, offices, and enterprises
That guest network you set up for your neighbors may not be as secure as you think.
Beyond Politics: A Haitian Immigrant’s Call To See People
Cedarville music professor Dr. Lou Lilite, a Haitian immigrant and U.S. citizen, urges neighbors to see immigrants as people, not labels. Visiting Springfield...
Boulder’s bleak oil-and-gas legal entanglements
Good neighbor policy in the fossil-fuel-energy industry stops at Boulder’s door. If any other county or municipality decides to rumble with Exxon Mobil and Suncor Energy over their legal exposure to climate lawsuits, those entities will no doubt face “Bleak House” type legal entanglements also. Charles Dickens’ Bleak House records the estate case of Jarndyce […]