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Apple's Cheapest 16-Inch MacBook Pro Just Got a Massive $563 Discount on Amazon
Apple's entry-level 16-inch MacBook Pro has received a massive discount today on Amazon, coming in at $563 off its new price. This is the 18-Core M5 Pro 16-inch MacBook Pro with 24GB RAM and a 1TB SSD, available for $2,436.53, down from $2,999.00. Note: MacRumors is an affiliate partner with some of these vendors. When you click a link and make a purchase, we may receive a small payment, which helps us keep the site running.
Bucaneers HC Issues Challenge to Rueben Bain Jr.
Fresh off an injury-plagued start, Tampa Bay’s prized rookie returns to spark a stagnant pass rush as the winless franchise fights to keep its postseason hopes alive.
SEVEN FEATHERS HEALTH: St. Pierre aims to help those in need and inspire the next generation
The drive for Dr. Dakota St. Pierre’s career is quite simple, to serve people in need, transform a health care system he views flawed and inspire young people who are
SEVEN FEATHERS HEALTH: St. Pierre aims to help those in need and inspire the next generation
Click here to view this video from cherokeephoenix.org.
2026 Heisman Poll Week Five
Welcome to the 2026 Heisman Poll Week Five. Alabama's Keelon Russell has entered the poll after a big win over Mississippi State. The same game also saw poll favorite Kamario Taylor get injured. We are getting deeper into the season, and the stakes keep climbing. To see all the movement from last week, check out …
Good Beer Festival is Returning to Salisbury Featuring Live Entertainment and Tasty Brews
We're previewing Salisbury's Good Beer Festival is where you can find live entertainment and over 100 craft brews, so we'll tell you why this event keeps people coming back year
The ‘WarGames’ Problem: Computer Science Has Long Understood What it Takes to Keep AI Under Control
AI agents don’t go rogue. That’s something only humans do. Nevertheless, a New York Times article – representative
Whipple Consulting Engineers expands offerings
Driven by recurring requests from custom homebuilders and small developers, Spokane Valley-based Whipple Consulting Engineers Inc. has expanded its offerings in an effort to keep costs manageable for smaller projects.
Anthropic and OpenAI are keeping other companies on the IPO sidelines
Everyone's waiting for Anthropic to go public. Buying the stock is another story.
Beloved Belleville gardening business to close after 21 years
After more than two decades helping customers make their yards more beautiful, Sandy’s Back Porch Gardens in Belleville is set to close its doors early next month. “I keep telling people that there are mountains to climb, hills to roam and rivers to raft, and I want to do all those things,” owner Sandy Richter said.
The Midterm Elections Won't Keep Trump From College Football on Saturday. A Hurricane Might
WASHINGTON (AP) — The midterm elections are looming and the first hurricane of the Atlantic Season is menacing the Gulf Coast. But President Donald Trump is really, really hoping the weather doesn’t stop him from going to another big college football game — this one in Alabama on Saturday night.
Seattle market owners worry ICE activity is hurting business
The owners of Mendoza’s Mexican Mercado, a 15-year staple along Seattle's Aurora Avenue, say sales have dropped 30% compared to last year as fear of U.S. Immigration and Customs Enforcement activity keeps customers away.
Who Won August and September: Original Films or Franchises?
(Welcome to the Entertainment Strategy Guy, a newsletter on the entertainment industry and business strategy. I write a weekly Streaming Ratings Report and a bi-weekly strategy column, along with occasional deep dives into other topics, like today’s article. Please subscribe.) I just heard someone say that if you’re reading a pundit or data analyst, and they don’t tell you that they got anything wrong, they’re not a pundit but an “influencer”. I agree with that. You have to tell your audience when you get things wrong, or they won’t (or shouldn’t) trust you as much. Today, we’ve got another edition of “What I Got Right, What I Got Wrong”. In general, I’m patting myself on the back (and patting very hard) about a few things like IP at the box office, LIV golf, horror films, crowdfunding movies, superheroes, and old people going to the theaters. That said, I also made a couple of data mistakes on the streaming bubble popping and HBO’s datecdotes, so I’m not perfect. But first, I need your feedback... Subscribe Follow-Ups: What Should We Call Mid-Budget Movies Which Aren’t Cinematic Enough for Theaters But Are Too Expensive to Make Money on Streaming? After I asked for feedback on what we should call straight-to-streaming films that are too big to pencil out on streaming but not really big enough to resonate in theaters, I got some great suggestions from you all, including... “Moldilocks” from John Aboud “Little Big Indie” from Travis Frick1 “Midflicks” from Jonathan Funke. “Extra-Medium” from Jona Nwuke. (Read the explanation in the footnote.) Between these and Brandon Katz—who suggested “Bermuda Budget Triangle”, “The Platform Gap” and “The Distribution Deadzone”—we’ve got some excellent suggestions. And they’re better than my suggestion, the “Streaming Budget Dead Zone”, so let’s take a poll! The winning entry becomes the new term. Loading... RIGHT: LIV Golf is Fully Bankrupt…Is Anyone Else Next? A few years ago, I was always a bit perplexed at all the articles I’d read praising LIV Golf and their strategy to disrupt the PGA. LIV Golf, a brand new professional golf league, offered PGA stars ten times what they made on the PGA Tour to join their new league. And folks praised this strategy for its initial “success” in that a lot of big names did indeed leave the PGA. Yeah, of course the players came over. LIV Golf paid them so, so, so much more! But LIV Golf hadn’t discovered a way to increase potential revenue. So think about this in basic business terms… They paid much more in costs… …but had no real way to increase revenue. That’s not a strategy! That’s deficit financing. It won’t work unless you bankrupt the competition (and then turn around and pay those same golfers much, much less). It’s not a sustainable strategy and only lasts as long as the company/person/nation backing it decides they’re cool with losing money. For LIV Golf, that meant Middle East oil wealth, in particular Saudi Arabian money. Clearly, the current Iran War has hurt Middle East finances, so they need to trim their more exorbitant spending. And LIV Golf was part of that trimming. This should be a major warning for others. TGL’s parent company, TMRW Sports, just got a $1 billion valuation, despite TGL’s (the indoor golf league) horrible TV viewership of less than half a million viewers per match. Unrivaled, the women’s basketball league, just secured a $650 valuation, despite its horrible TV viewership and a new rival (Project B) entering the scene next year. To relate this to streaming, Hollywood should ask which streamers may have wealthy patrons funding their losses. (Let’s be clear: Google, Amazon and Apple.) Could those patrons lose their appetite? For Amazon, probably not. But Apple has a new boss, so maybe! WRONG: My Analysis of the Streaming Bubble Was Missing a Week I’m going to be congratulating myself a lot today, but I make mistakes too, like this data goof. When I last compiled the data on the decline in TV shows, I was missing one week at the end of June. If you look at the first image, you can see that one week was mislabelled as “July”. Mainly, this image got updated to show a 27% decline, not 29%: This change doesn’t really impact the overall analysis, but it is two percent better. By the way, through the third quarter, the decline increased and it’s now a 30% decrease since 2022. (I’ll write/visualize this in an upcoming article.) But I want you to trust me and my data. Especially these days, when many people are using LLMs that I know are inserting faulty data into their charts, I want to keep earning my audience’s faith. So that’s the accurate data. RIGHT: IP Remains Very, Very Popular In July, I wrote a giant (and I mean giant) article on Backrooms, Obsession, and the box office, going over what we know, what we don’t know about what works in theaters, looking at YouTubers, IP, the horror genre, comic book movies, and a whole lot more. The month of August really tested a lot of my theses and, being honest, mostly supported my arguments. Let’s start with IP. Looking at 8-Aug (the weekend after Spider-Man: Brand New Day came out) to 18-Sep (the weekend that Resident Evil came out, which I think provides a nice bookend to this time period), there were seven films based on pre-existing IP: Resident Evil (2026) ($126 million) Practical Magic 2 ($65 million) _Insidious: Out of the Furthe_r ($65 million) Coyote Vs. Acme ($59 million) Paw Patrol: The Dino Movie ($53 million) Tony ($15 million) Super Troopers 3 ($7 million) Compare those to the notable original films from the past month—I actually could have included more movies, but here are just thirteen, bringing us to an even twenty films—including.... The End of Oak Street ($54 million) Buddy ($26 million) Mutiny ($15 million) By Any Means ($15 million) The Dog Stars ($14 million) Runner ($14 million) One Night Only ($11 million) Hope ($8 million) Spa Weekend ($7 million) The Uprising ($6 million) Teenage Sex and Death at Camp Miasma ($6 million) Onslaught ($3 million) Eli Roth’s Ice Cream Man ($2.8 million) Here’s that in chart form: Five of the top six films in this time period were all based on IP. I made a big chart of films that grossed over $200 million at the box office before Spider-Man: Brand New Day and The Odyssey hit theaters. Let’s update that chart! By the way, if you want to see how I categorized each film—so another bar chart—here it is: I know that many of my fellow critics/pundits/analysts dislike films based on IP and how Hollywood is making so many of them. And I’m sympathetic to this point of view. As I’ve written many, many times before, you need a balance between existing franchises, new IP, and original films. And Hollywood clearly needs to make more films like Resident Evil (a well-made film from a visionary director) and fewer Practical Magic 2’s (which didn’t get critical or customer buzz). But at some point, critics and pundits need to contend with what audiences are telling them: Movie-goers aren’t showing up to original films. Audiences are speaking with their dollars, telling you they want more IP and franchises. You can try to convince studio heads to make fewer IP-based films and franchises, but the data and numbers aren’t there. Instead, critics need to work harder to convince audiences to show up for original films. Aim your ire/concern at the average person, not studio heads.2 Because they’re just making the films that audiences are telling them to make. WRONG: Original Horror Films Didn’t Break Out I’ll be honest, even though I wrote an article casting some skepticism on the horror genre in July, if you asked me to make a prediction, I would have predicted that, in August, a new, original horror film would have blown up. No, seriously, I just assumed that Obsession and Backrooms presaged a change in audience behavior. But none of the buzzy new original horror films from August—Teenage Sex and Death at Camp Miasma, Onslaught (not an action film in spite of the ads), The End of Oak Street, Eli Roth’s Ice Cream Man, or _Buddy—_broke out. To be clear, exactly one of those films (Buddy) had good “ROI”, but again—I try to be specific in my language—none were “popular” in any broad sense of the word. None of them will be “saving” movies theaters like Backrooms or _Obsession_helped save the summer. The new Insidious film and Resident Evil, both based on IP, were far and away the biggest horror films since July. (We’ll see if this changes in October/Halloween season.) RIGHT: Stay Skeptical about Crowdfunding... I’ve long been skeptical about crowd-investing platforms as one of Hollywood’s saviors, mainly because there’s so much hype/buzz. People need to stay more skeptical about more things, explaining both the potential upside but also the downsides. In particular, the media often hypes crowdfunding at the start and never checks in on the actual results after they’ve come in later. And August gave us our first update! _Ice Cream Man—_directed by Eli Roth—grossed $6 million off of a $5.5 million budget. This is a production of The Horror Section, which was one of the first “crowd investing” studios with 2,400 investors, which means that 2,400 investors probably lost money. They certainly aren’t getting as great of returns as if they had just invested their dollars in the stock market. Hopefully Stiletto (Tagline: “Someone’s Going to Make it Rain Blood!”) does better next month. WRONG: Another Data Goof Here’s another data error. When the first episode of House of the Dragon came out, HBO put out that it had 21.5 million viewers in the first three days, and I read that to mean in the US…but no, it was global. So my US-only datecdotes charts shouldn’t have included it. We never got US-only numbers for the first episode, but for the final episode, HBO put out that it had 11 million US viewers. (And that global dropped to 21 million viewers.) Here’s the updated chart (which I’ve since used in the Streaming Ratings Report): Still, this show is absolutely huge. RIGHT: Superhero Films Remain Very, Very Popular After Supergirl flopped, I read a few takes that “comic book movies are going the way of the Western”. Post-Spider-Man: Brand New Day, that take didn’t age well. To be fair, I have a very nuanced take on the superhero genre right now; it’s down right now, for a lot of reasons. But it’s not “dead”. Maybe _Spider-_Man is just a really popular character? I saw that take, and it’s a fair counter-argument. (But pundits arguing that superhero movies were dead should have mentioned this $1.5 billion counter-argument…) But is it just Spider-Man? The next Avengers film already has $50 million in pre-sales (and I was skeptical that that film would do well) and the Avengers: End Game re-release topped the box office two weekends ago (over three original films). And I wouldn’t bet against Batman or Superman. So maybe it’s just Spider-Man, Batman, Superman and the Avengers. Oh, and Deadpool, of course. And Black Panther. And Wolverine. And probably the X-Men. Plus a well-made Wonder Woman or the Hulk film could break out. But that’s it! It’s just those ten characters/teams. Oh, what’s that? Lanterns is also doing well on HBO? (See previous section…) To be fair, I’m actually pretty sympathetic to the argument that more popular characters—like Spider-Man and Batman—anchor more popular films. In fact, I made that exact argument three years ago when I first wrote about the “Marvel-cession”. In many ways, you can blame The Guardians of the Galaxy for fooling Marvel Studios (and the rest of us) into believing that any character could pop. It turns out, the list of iconic characters is probably smaller than most people think. But it’s probably too early to say that superhero films and comic book movies are dead unless “death” means a slight decline over a longtime. RIGHT: Who Killed Theaters? Old People I get frustrated whenever I see headlines or analysis about how young people are “returning” to theaters. As I’ve detailed(for years), young people have always powered the US box office, despite narratives about “kids these days” and their “phones”. Really, what’s changed post-2020/pandemic is that old people aren’t going to the movies nearly as much. This summer, I saw a movie (from an older director) in a theater near a retirement community, and multiple older people at the theater were talking about how this was their first time seeing a movie in years. I dislike personal anecdotes, so YouGov can fill in the data, best summarized by this headline: “Who killed movie theaters? Not the youths”. According to them, 64% of people aged 18-29 have seen a movie in the last year, but only 30% of 65-and-older. 20% of 18-29 have seen a movie in theaters in the last week and 42% in the last month. Here’s the polling data: Most concerning? Many Americans (17%) think theaters are a worse or much worse experience than watching films at home. Slight WRONG: Hadestown Opens Big A live theater capture of the Broadway musical, Hadestown, made $20 million at the US box office, which begs the question: was I wrong to be skeptical about musicals a few years ago? Yes and no. On the one hand, $20 million is a far cry from being “popular”, so yeah, the genre isn’t that popular overall and Hadestown is one of the more popular musicals from recent years (i.e. the “Taylor Swift Data Fallacy” in action). On the other, I doubt filming this cost all that much, and I don’t think that they spent much on marketing, so this is a good source of ancillary revenue. Smaller Updates WRONG: As I mentioned in a Streaming Ratings Report, I underestimated the budget for Enola Holmes 3. It probably cost more like $50 million, if not more. But... I’m not sure that it really matters? At sub-10 million hours, prices have to come down to make this work. WRONG: Netflix is giving Ink a 27-day in theaters! To quote the kids/YouTubers these days, let’s go! Now I might actually have a chance to see Danny Boyle’s latest in theaters. I’d complained about this in a “Coming Soon” section, but I was heartened to read that Netflix is giving multiple films longer theatrical windows this year. RIGHT: Netflix is sending 4-5 films per year to theaters. Netflix is slowly but surely sending more and more films to theaters, as I cautiously predicted earlier this year. For now, it’s just three big films and a number of awards contenders, but still, this is great news. And they’ll be releasing box office grosses! Just this week, Ted Sarandos confirmed that KPop Demon Hunters 2 will come to theaters (and my guess is it performs in the box office top ten at a minimum). WRONG: Angel has 3 million subscribers! How do I know this? Well, they told Deadline, who reported it. I marked this as “wrong”, since they’ve doubled their subscribers in one year but, you know, they don’t really have a hit film to speak of and they’re still losing money. WRONG: Furious was only renewed for one more season. I accidentally wrote “two more seasons” in my latest “Renewals, Cancellations, Un-Orders and Removals Update”. RIGHT: House of David is ending with its third season. In July, Prime Video renewed House of David for a third season, as I just wrote in my latest “Renewals and Cancellations” report. Well, now it’s ending after that third season. Why? As I’ve been writing, its viewership wasn’t great. I got feedback that this show didn’t cost very much, but it cost enough that its limited viewership didn’t save it. WRONG: Adults was a Hulu original! So I missed Adults when it first came out last year; I saw that it aired on FX and just assumed that it was a linear-first program. Turns out, it aired three episodes on FX, but binge-released the rest of its episodes the next day on Hulu. Huh. So I should have covered it last year! But I just wrote about it. 1 “When I was a kid in the 90s, if you wore a t-shirt to school that wasn’t too big and also wasn’t too small, but somehow didn’t quite fit, we’d say you were wearing an “extra-medium” shirt.” 2 As always, a huge exception is Disney, which barely makes anything original anymore.
Skyler Gisondo knows he's having (another) viral moment right now
An old red carpet photo of the actor is the gift that keeps on giving, this time becoming a vehicle for childhood nostalgia.
Hall Pass: Your Ticket to Understanding School Board Politics, Edition #226
Welcome to Hall Pass, a newsletter written to keep you plugged into the conversations driving school board governance, the politics surrounding it, and education policy. In today’s edition, you’ll find: On the issues: The debate over Career and Technical Education (CTE) In this section, we curate reporting, analysis, and commentary on the issues school board members […]
Old Boxers Never Die on Robert Street
The London Memorabilia Fair plays an important role in keeping boxing's glorious history alive
ChatGPT for Teens keeps teens talking, even during mental health crises
ChatGPT’s teen safeguards are meant to protect vulnerable users, but new testing found the chatbot continues encouraging engagement during crises and potentially encourages unhealthy relationships with the AI itself.
How to do your own bookkeeping as a small business owner
Learn how to keep accurate records, stay organized and prepare for tax season with accounting software like QuickBooks Free.
The Low Block, week 7: Going for broke
Let’s all try to keep a level head after this one.
The age of nuclear clocks is here: A new tool for probing the laws of physics
Chinese and European scientists have unveiled prototypes that usher in a new era of timekeeping, using thorium-229 as their ‘pendulum’
You Can Get Up to $149 Off Every New Mac Mini During Prime Day
Prime Big Deal Days sales have hit Apple's brand new Mac mini and Mac Studio computers, and we're tracking up to $149 off every model of the M6 and M5 Pro Mac mini during this year's event. You'll also find $199 off the M5 Max Mac Studio below. Note: MacRumors is an affiliate partner with some of these vendors. When you click a link and make a purchase, we may receive a small payment, which helps us keep the site running.
Scientists in Vienna and Beijing create world's first nuclear clocks
Oct 7 (Reuters) - Scientific teams working separately in Vienna and Beijing have developed the world's first two operating nuclear clocks in what they are calling an important advance in timekeeping t...
Scientists in Vienna and Beijing create world's first nuclear clocks
Scientific teams working separately in Vienna and Beijing have developed the world's first two operating nuclear clocks in what they are calling an important advance in timekeeping that promises wide-ranging practical applications and offers a new tool to investigate fundamental physics.
The Best Anker Prime Day Deals: Score Big on MagSafe Chargers and More
Anker's Prime 3-in-1 Wireless Charging Station has dropped to $94.74 on Amazon during Prime Big Deal Days, down from $149.99. This is a new all-time low price that beats the previous low by about $5, and it's accompanied by dozens of other Anker discounts this Prime Day. Note: MacRumors is an affiliate partner with some of these vendors. When you click a link and make a purchase, we may receive a small payment, which helps us keep the site running.
Prime Day Offers Best TV Prices of the Year From Samsung, Sony, and More
Prime Big Deal Days is in full swing this week, offering massive savings on everything from AirPods to MacBook Pro and much more. We've been keeping an eye on these Apple-related Prime Day discounts all week, but now we're also tracking great sales on other categories, including TVs. Note: MacRumors is an affiliate partner with Amazon. When you click a link and make a purchase, we may receive a small payment, which helps us keep the site running.
Is Telekinesis Real? What Science Actually Says
Researchers have chased mind over matter for more than a century, but the effect keeps shrinking as the studies get bigger.
Browns will be monitoring the health of Ravens QB Lamar Jackson
Cleveland will be keeping a close eye on the ankle of Lamar Jackson.
HOMETOWN HEALTH: How to keep the weight off after stopping GLP-1 drug
Many people rapidly regain weight after stopping GLP-1 weight loss drugs
Broncos at Chargers preview: Denver hunts for first divisional win
The Broncos head to LA on Sunday looking to rebound from a loss to the 49ers. Denver looks to keep the Chargers winless.
Why Markets Are Buoyant
Energy and technology companies’ earnings are expected to keep driving up stock indexes. But what’s driving up their profits are weighing on the economy.
🚨 BREAKING: Mikel Arteta signs new Arsenal deal until 2030
Arsenal have announced that manager Mikel Arteta has signed a new contract that will keep him at the club until 2030.The deal makes Arteta the highest-paid manager in the Premier League, underlining A...
Arctic Wolf CEO: AI Has Changed Cybersecurity Forever
Arctic Wolf CEO Nick Schneider joins the Twin Cities Business Show to talk about how artificial intelligence has fundamentally changed cybersecurity. According to Schneider, we are already past the point where humans can defend against agents, and need agents of their own to keep themselves safe. Schneider explains how AI is giving cybercriminals new capabilities,
Push aims to keep North Dakota businesses local through employee ownership
In the state, there are 64 employee-owned businesses representing about 30,000 employee owners.
Half a billion dollars in GOP spending does little to move polls
Republicans’ massive money advantage has yet to reshape the midterm map, as Democrats keep expanding their ambitions.
Your Business Should Make You Wealthy, Not Just Keep You Busy
Build a business that creates wealth, not just work. Learn how to turn profits, cash flow and business value into long-term personal wealth.
Kobel reflects on Newcastle interest and his Borussia Dortmund future
Borussia Dortmund goalkeeper Gregor Kobel has consistently been linked with a transfer over the past few years.Last summer, Newcastle United were reportedly interested in the Swiss shot-stopper, but h...
Wrexham's Kop: The project matching the club's rise
Wrexham's new Kop stand a signal of their ambition to keep climbing from the Championship to the Premier League.
Redoing Daubert: Are judges letting bad science back into the court room?
Daubert was meant to keep unreliable science out of the courtroom by making judges gatekeepers who ensure the reliability and relevance of expert testimony and the underlying research. A recent Second Circuit decision raises a harder question: how deeply may a judge examine the science when evaluating an expert’s methodology before determining the scientific dispute itself? The answer could reshape how courts translate epidemiological evidence into legal proof.
Tillis says ‘it’s tough’ convincing voters to keep GOP in control of House & Senate
How to help stop spam calls on iPhone and Android
Keep spam calls at bay with built-in tools in Android and iOS; you can silence them without having to subscribe to third-party apps.
Should the Cowboys Be Interested in a Khalil Mack Trade?
Khalil Mack could become available if the Chargers keep losing. Should the Cowboys explore a trade for the 35-year-old pass rusher?
New Clinical Guideline Helps Keep Women 'Optimized for the Fight'
The Department of Veterans Affairs and War Department have jointly released a clinical practice guideline to help clinicians provide improved care for women experiencing perimenopause and menopause.
What a way to reject a lawsuit
The company managing Dolly Parton’s estate alleges the late singer’s nephew, Bryan Seaver, used barbed wire and yellow caution tape to help keep a process server at bay, according to Rolling Stone.
UNC Health breaks ground on Research Triangle Park hospital
UNC Health views the hospital as critical to keeping up with the Triangle's growing population.
Amazon Prime’s 10 ‘free’ games for October include Five Nights at Freddy’s: Into the Pit and Doom 2016
Amazon Prime subscribers can claim the games to keep via its Luna service…
Anker’s 100W universal charger is a great travel gadget for $64
Keep your devices charged up during your travels.
Stephen Wacker outlines his ‘new mandate’ for every Marvel comic
New Marvel EIC Stephen Wacker wants every Marvel comic to give readers enough context and excitement to keep reading, regardless of where they jump aboard.
Ten Tips to Keep Your Business Cybersafe
Cybersecurity threats can put your business, data and customers at risk. These 10 practical steps can help strengthen your organization’s cyber-readiness.
AI founders for hire: Startup hub Foundations launches service to connect businesses with builders
Foundations Design and Engineering is meant in part to give founders a new way to fund their companies as early-stage investment gets harder to raise. Prices and the share of each contract that Foundations will keep are still being worked out.
Another sign of rapidly expanding political map: Pollsters can’t keep up
Increased demand for polling has strained call centers that conduct surveys, squeezed capacity and complicated the task of getting accurate reads on public opinion, according to pollsters.
US Congresswoman Joins Fight to Keep Cannabis Legal in Massachusetts
Rep. Ayanna Pressley is urging Massachusetts voters to reject a ballot measure that aims to repeal the state’s adult-use cannabis laws.
Ronald Waterreus Defends Matej Kovar Amid 'Unfair' PSV Criticism
Former PSV player Waterreus tackles the harsh scrutiny surrounding the Czech keeper, highlighting a crucial Harry Kane save while questioning if tactical demands lead to his perceived errors.
‘Business for Democracy’ Sees Friends Rising and Keep Showing Up Rally in Downtown Plaza
On a scorching 100-degree Saturday midday on October 3, 2026, local volunteers from Culver City and Friends Rising, joined by Keep Showing Up Culver City, led a march and rally. The demonstration f…
US stocks hit record high, shrugging off bond market turmoil
The artificial intelligence boom keeps rolling, sending stocks to record highs: The S&P 500 rose 0.7% on Tuesday and hit 7,830 points, an all-time high and its first intraday record high in almost two months.
California leaders slam Trump for saying Iran could ‘take out’ L.A. or San Diego
Officials in California condemned the president's comments as “dangerous,” after he told a Nebraska rally the war in Iran was a “small price to pay for keeping the world safe.”
Apple's Entire Mac Lineup Gets Massive Discounts for Prime Day
Prime Big Deal Days is in full swing, and we've already begun tracking the best Apple discounts during Amazon's big fall event. This year, there are notable markdowns across Apple's Mac lineup, including the MacBook Air, MacBook Pro, and brand new Mac mini and Mac Studio. MacBook Air Note: MacRumors is an affiliate partner with some of these vendors. When you click a link and make a purchase, we may receive a small payment, which helps us keep the site running.
We need CI-132 to keep politics and money out of our courts
Please join me in voting yes on CI-132 this November so we can protect our tradition of elected judges based on their record and qualifications and keep politics out of
The Kids in the Arena: Spectrum Business Keeps Florida Esports Facility Connected
With Spectrum Business Internet Gig, Valhallan Esports Training now has reliable high-speed, low-latency connectivity so young gamers have a safe, supportive environment to play their favorite games.
Ndour on Juventus radar after firing Azzurrini to Euros
Juventus are among several clubs keeping tabs on Cher Ndour after the Fiorentina midfielder fired Italy’s Under-21s to the European Championship.According to Tuttomercatoweb, the Bianconeri see the ...
Newcastle goalkeeper emerges as option for Bayern Munich
With Manuel Neuer expected to retire from football next summer, Bayern Munich already have a successor in place for the veteran in the shape of Jonas Urbig.However, the Bavarians still want to bring i...
Keeping up with the Bolsonaros: Flávio’s surprise first-round election win heralds rise of a political dynasty
Four members of disgraced ex-president Jair Bolsonaro’s family have been elected to office, most notably his wife and son Flávio, who won the first round of voting to be Brazil’s new president
New WVU Bowl Projection Comes With a Fascinating Twist
The West Virginia Mountaineers have lost consecutive Big 12 games, but one new bowl projection gives fans an interesting reason to keep thinking about what could still be waiting at the end of the season. WVU fell to 3-2 following its 45-42 loss to Iowa State on Oct. 3. Rich Rodriguez’s team is now 0-2 in […] The post New WVU Bowl Projection Comes With a Fascinating Twist appeared first on HEAVY.
8 Fermented Foods To Add to Your Diet
Fermented foods like pickles and kimchi can help keep your gut health. An expert shares which foods are worth adding to your meals.
In Business: Bemidji Woolen Mills Keeping Local Production Alive
https://youtu.be/dwmn4Xteru4 As more clothing production moves overseas, one Bemidji manufacturer is still keeping much of its work local. Behind the racks and finished products at the Bemidji Woolen Mills, much of the work here still comes down to people cutting, stitching, and sewing. In an industry where production has often…
Two Overlooked Stars Keeping Packers Alive
The 2026 Green Bay Packers look and feel like a bad team that has miraculously beaten even worse teams. The coaching and scheme have not consistently aligned with the players’ abilities to execute, while gut-wrenching injuries have left Green Bay relying on backups across multiple position groups. And it is only Week 5. For a …
The ‘War Games’ problem: Computer science has long understood what it takes to keep AI under control
AI agents don’t go rogue. That’s something only humans do. Nevertheless, a New York Times article – representative of much news coverage of AI – described an OpenAI hacking as “A.I. bots going rogue and independently spearheading a cyberattack.” Name-brand artificial intelligence agents have been on a hacking spree in…
Eagles address uncertainty surrounding missing star
Will Eagles star return? Team is keeping quiet.
Ted Cruz Says JD Vance’s ‘Political Bomb-Throwing’ Shows He’s ‘Insecure’ Ahead of 2028 Election
While Vice President JD Vance might have been floated as a potential frontrunner for the Republican presidential nomination in the 2028 election, Senator Ted Cruz is doing his part to keep the party’s...
Why I Don’t Think Ride Or Die Should Have Been Cancelled (And What Company Should Save It...)
(Welcome to my weekly streaming ratings report, the single best guide to what’s popular in streaming TV and what isn’t. I’m the Entertainment Strategy Guy, a former streaming executive who now analyzes business strategy in the entertainment industry. If you were forwarded this email, please subscribe to get these insights each week.) So…I recently came across a Reddit thread, talking about films on streaming, wondering why there are no reliable sources out there for streaming ratings data. Sigh. Honestly, as annoyed as I am that so many still don’t realize that we have streaming ratings, I somewhat get it. Until now, there was such a long delay between when a show or film came to streaming and when we got its viewership data; I understand why people were confused. (But, as you know, this just changed.) Also, even back in the day, how many people knew how well films did on television? Luckily, as a reader, you’re in the know. Okay, on to this week’s issue. I want to take a look at Prime Video cancelling Ride or Die and whether I agree with that decision. Overall, we didn’t have any breakout hits (no TV shows landed over 20 million hours according to Nielsen) but we have a lot of steady performers on the streaming charts. Plus, we’ll look at where $50 million in missing box office dollars went. (Spoiler: straight-to-streaming.) All that, plus new episodes of The Secret Lives of Mormon Wives, Supergirl heads to streaming, a new YA show does well on Netflix, the viewership for the Daily Wire’s $50 million fantasy show, what TV show hit-maker can’t make streaming hits, CD sales, all the flops, bombs and misses, and a whole lot more. Let’s dive right in! (Reminder: The streaming ratings report focuses on the U.S. market and compiles data from Nielsen’s weekly top ten viewership ranks, Luminate’s Top Ten Data, JustWatch and Reelgood interest data, Samba TV household viewership, company datecdotes, Netflix hours viewed data, Google Trends, and IMDb to determine the most popular content. While most data points are current, Nielsen’s data covers the weeks of September 7th to September 13th, 2026. You can find a link to my terminology here.) Subscribe Television - Ride or Die Is a Hit…But It Got Cancelled? What The Data “Says” I hate the phrase “here’s what the data says”, even though sometimes I find myself using it. If data just told us everything, we data folks would be out of a job! Data is often messy, complicated and nuanced. When it comes to strategy, many of the best decisions can’t actually use “data”, since it’s vastly too complicated to model. Anyways, I’ve been singing the praises of Prime Video’s Ride Or Die this summer, a show that did very well for them. And yet…it got cancelled. Now, usually when a show gets cancelled, a bunch of websites say “a hit show got cancelled”... Here’s the thing, though: in this case, they’re right! The data “says” that this show was a hit. Specifically, out of 522 first seasons to make a week on the Nielsen charts since 2020, it’s the 75th biggest. On Amazon, Ride or Die is eighth out of 41 first seasons: That’s top 15th percentile all time, almost exactly, which is my definition of a “hit”! I mean, outside of Reacher, Amazon needed a hit this summer! (Admittedly, Off Campus did well for Amazon in the spring, but Ride or Die performed even better.) So what happened? Why did Amazon cancel one of their rare 2026 bright spots? Well, Deadline reported a reason—which I’ll get to—but I’d break it down into three relevant questions: What is a given streamer’s reasoning? Is that reasoning sound? Could the stated reason not be the real reason? According to Deadline, Amazon felt the show “over-indexed” in middle-aged women. (This was based on leaks from within Amazon.) The logic is this: Amazon already reaches this demographic because of unlimited two-day shipping bundled with Prime, so they don’t really need more shows like this. Now, it’s my job to ask if that’s a good reason, and I’ll be honest, in this case, I don’t think it is. Sure, this show may “over-index” in middle-aged women—I’ll just assume that’s the case here—but I think folks often oversell how important over-indexing actually is. When a show is a “hit”, it isn’t a bit bigger than its rivals; it’s usually multiples bigger. For example, Elle only made the charts for two weeks at 8.3 million hours each. So Ride or Die was 80% bigger in its first two weeks, and likely had a much stronger hold, with its terrific 13 million hours in week three. Ride or Die was nearly three times bigger than Sterling Point through three weeks too. And that means that _Elle, Sterling Point a_nd other Amazon YA shows need to not just over-index a little with younger women (assuming that’s who Amazon prefers over middle-aged women), but massively over-index. Otherwise, more people in that demo (and a bunch more besides) likely watched Ride or Die. (I’ll try to explore this concept more in a future article.) And don’t get me started on how Ride or Die did compared to a certain (very, very popular, possibly the world’s most popular) YouTuber’s reality show…which didn’t make the charts after its first week and likely cost much, much more than Ride or Die. All to say, Amazon-MGM Studios/Prime Video can tell reporters that this show didn’t reach the right audience, but that excuse feels weak to me. So this leads to the third question: could other reasons have come into play? Yes! Renewal or cancellation decisions rarely (I’m tempted to say “never”) boil down to one variable. At its simplest, it’s two things: budget versus viewership. But often factors like critical acclaim, ownership and, yes, personal opinion come into play. In this case, Amazon has a new executive running things, and this show isn’t owned by Amazon-MGM Studios (unlike Elle). And yes, it may not have indexed with the right target viewers, too. Likely all of those factors came into play.1 My guess is ownership ended up mattering most. Amazon doesn’t own Ride or Die. It’s actually produced by another major studio. Fortunately/allegedly, this show is being shopped around. I can think of one brand new CEO who should consider it for one of his two major streamers…especially if he wants to rebuild goodwill in Hollywood. His name is on this list of exec producers of Ride or Die… If David Ellison needs some goodwill—and he does—rescue this female-led show tomorrow and grab some good headlines for a day. The data justifies it. Quick Notes on TV We’re just getting started with this issue, but the rest is for paid subscribers of the Entertainment Strategy Guy, so if you’d like to find out… How The Secret Lives of Mormon Wives latest season did on Hulu, post-controversy... Whether Supergirl soared on HBO Max... Why the box office is losing money due to the streamers... The viewership for the Daily Wire’s $50 million fantasy show... Updates on The Gentlemen, Lanterns, Outer Banks, King of the Hill and more... What former hit-maker has three streaming flops in a row... Whether The Mandalorian and Grogu popped in week two... All the flops, bombs and misses... And a whole lot more... ...please subscribe! We can only keep doing this great work with your support. If you want an idea of just how much content you’d get in a full issue, check out this older issue. Coming Soon! Oh man, we’re almost caught up! We just have two more issues, then the streaming Ratings Report will be coming out just two weeks after a TV show premieres! Next issue, I’ll be looking at the first two weeks of the NFL Thursday night games on streaming, a huge new spinoff, Reacher’s Neagly on Prime Video, and the latest edition of Monster: The Lizzie Borden Story on Netflix, the return of Slow Horses on Apple and MobLand (quietly one of their biggest shows) on Paramount+, and Dancing with the Stars on both ABC and Disney+. Plus I’ll take a look at animation for adults in 2026. The week after, a ton of movies are coming to streaming: Toy Story 5 on Disney+, Backrooms on HBO Max, Jackass: Best and Last on Paramount+ and The Breadwinner on Netflix, plus a Unabomber film on Netflix and a romcom on Prime Video. Woody Harrelson and Matthew McConaughey have a show on Apple, along with a game show inspired by Willy Wonka that everyone seems to hate. Long term, some crazy (but hopefully crazy like a fox) IP news. FX ordered a new Sons of Anarchy show from Charlie Hunnam, but it’s not about the biker gang. No, it features the show’s cast playing themselves in a new “meta-thriller”. Huh. And a lot of the cast is coming back. Next, Ryan Gosling is producing a Flintstones movie about a “grown-up Bamm-Bamm Rubble”. Also, huh. This one is in “early development” so we’ll see what happens. Both projects are based on IP, but also seem to have crazy takes on the IP, which I like.
'If You Can Keep It': Mental Health And Democracy
A veteran journalist covered the Jan. 6 attacks on the Capitol. That experience got her exploring the connection between stress, trauma, and our political choices.Our mental health might affect our politics. But our politics also definitely affect our mental health.In this edition of “If You Can Keep It,” we examine that intersection.Find more of our programs online. Listen to 1A sponsor-free by signing up for 1A+ at plus.npr.org/the1a.
Banijay Entertainment Consolidates U.S. Operations to 'Banijay America' Under CEO Ben Samek
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‘NCIS’ Star Mark Harmon Reveals Why He and His Wife Pam Dawber Keep a Low Profile
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The AI Advantage Minnesota Has Been Building for Decades
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‘An anchor’: Oakshire fans celebrate, grieve as business prepares to shut down
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Top Links 1245 Jobs in health care. Jobs for women. The US labour market is segmenting. Chernobyl’s radiation and Lenin’s love of literature.
Thank you for your support of Chartbook. Your generosity keeps this show on the road. Elmer Bischoff, Two Figures at the Seashore, 1957 The only really dynamic job-creator in the US economy is health care:
Jobs in health care. Jobs for women. The US labour market is segmenting. Chernobyl’s radiation and Lenin’s love of literature.
Thank you for opening your Chartbook email. Elmer Bischoff, Two Figures at the Seashore, 1957 The only really dynamic job-creator in the US economy is health care: The largest crunch has come in Federal government, which has shed 2.7 m jobs. Source: tchouvkov on Twitter Tech is struggling. [ Joey Politano 🏳️🌈@JosephPolitano The US tech sector continues bleeding jobs in official data released today—overall, employment decreased by 17k last month and is down 69k over the last year That's nearly as bad as the worst of the 2024 tech-cession, and much worse than the 2022 boom or even pre-2020 norms 12:42 PM · Oct 2, 2026 · 15.2K Views 15 Replies · 47 Reposts · 390 Likes ](https://x.com/JosephPolitano/status/2106001807847940232?s=20) The new jobs are all for women. [ Justin Wolfers@JustinWolfers I'm not sure who saw this coming, but so far nearly all the jobs created during the second Trump administration have gone to women. 1:09 PM · Oct 2, 2026 · 33K Views 70 Replies · 146 Reposts · 644 Likes ](https://x.com/JustinWolfers/status/2106008723533533601?s=20) Meanwhile, real wages are being eaten up by modest over-target inflation. [ Heather Long@byHeatherLong The financial pain is real: Wage growth fell to 3% (y/y) in September. That's the lowest in 5 years. Wage growth: 3% Inflation: ~3.4% Inflation has eaten up all wage gains for the average worker since April. Many people are having to make hard choices about what to buy and what … 1:24 PM · Oct 2, 2026 · 37K Views 24 Replies · 275 Reposts · 533 Likes ](https://x.com/byHeatherLong/status/2106012367712620728?s=20) HEY READERS, THANK YOU for opening the Chartbook email. I hope it brightens your day. I enjoy putting out the newsletter, but tbh, what keeps this flow going is the generosity of those readers who clicked the subscription button. If you are persuaded to click, please consider the annual subscription of $60. It is both better value for you and a much better deal for me, as it involves only one credit card charge. Why feed the payments companies if we don’t have to. Subscribe Elmer Bischoff, Bathers, 1960 Americans are disillusioned with higher ed. For contributing subscribers only. Subscribe Where the Chernobyl radiation went. h/t Simon Kuestenmacher aka simongerman600 How Lenin’s love of literature shaped the Russian Revolution - Tariq Ali This, then, was the intellectual atmosphere in which Lenin came of age. His father, a highly cultured conservative, was the chief inspector of schools in his region and much respected as an educationalist. At home, Shakespeare, Goethe and Pushkin, among others, were read aloud on Sunday afternoons. It was impossible for the Ulyanov family – “Lenin” was a pseudonym adopted to outwit the tsarist secret police – to escape high culture. At high school, Lenin fell in love with Latin. His headteacher had high hopes that he might become a philologist and Latin scholar. History willed otherwise, but Lenin’s passion for Latin, and taste for the classics, never left him. He read Virgil, Ovid, Horace and Juvenal in the original, as well as Roman senatorial orations. He devoured Goethe during his two decades in exile, reading and rereading Faust many times. Lenin put his knowledge of the classics to good use in the time leading up to the October revolution of 1917. In April of that year, he broke with Russian social-democratic orthodoxy and, in a set of radical theses, called for a socialist revolution in Russia. A number of his own close comrades denounced him. In a sharp riposte, Lenin quoted Mephistopheles from Goethe’s masterwork: “Theory, my friend, is grey, but green is the eternal tree of life.” Source: The Guardian Elmer Bischoff, The River, 1953 If you’ve scrolled this far, you know you want to click: Subscribe
Yale School of Medicine On the Science of Childhood Anxiety, Say, Anxiety Disorders Are the Most Common Mental Health Challenges In Youth
Credit: Matt Bradbury October 5, 2026 - By Isabella Backman - Anxiety disorders are the most common mental health challenges in youth. Left untreated, they can disrupt the lives of both children and their families. The good news is that with intervention, most children will overcome these conditions. Across Yale School of Medicine, scientists are working to understand anxiety at every level, from common anxious behaviors to molecular biomarkers in the brain. They are using their findings to develop and disseminate new evidence-based treatments for childhood anxiety. Today, the go-to treatment for childhood anxiety disorders is cognitive behavioral therapy (CBT). This is a form of psychotherapy that teaches children skills for confronting anxious thoughts and helps them practice managing situations that cause anxiety. While it is the gold-standard treatment backed by considerable scientific evidence, up to 50% of children will not see sufficient benefit from CBT alone. Wendy Silverman, PhD, Alfred A. Messer Professor in the Child Study Center, co-directs the Anxiety and Mood Disorders Program alongside Eli Lebowitz, PhD, associate professor in the Child Study Center. One of their main interests is learning how to improve outcomes beyond CBT. “We’re developing cutting-edge, research-based knowledge that can reduce the suffering that anxiety causes children and their families,” says Silverman. Changing parent behavior YSM experts are investigating how to improve CBT outcomes for children by involving the parents. Silverman’s research has uncovered two main components of parent intervention that improve childhood anxiety: not enabling children to completely avoid the things that make them anxious and taking steps to enhance their autonomy. Parents may unintentionally reinforce their child’s anxiety by allowing them to avoid what makes them anxious. They also may unintentionally limit the children’s sense of autonomy by being overly intrusive. “One of the things that we take pride in is that we’ve focused on trying to understand what parents need to do, and to test our ideas and see if changing the parents’ behaviors is enhancing the effects of CBT,” Silverman says. “Our findings thus far suggest that they do." As much as CBT can be helpful, it can also be challenging to get one’s child to do the necessary steps for CBT to work. This is one important reason why Lebowitz created a novel intervention program for parents named Supportive Parenting for Anxious Childhood Emotions (SPACE). Existing intervention programs often teach parents to act as therapists for their child, such as training them on how to practice breathing exercises. “It makes sense, but this doesn’t work very well in practice,” says Lebowitz. “And part of the reason, I think, is that it’s not easy to get your kid to do things, especially if they’re not excited about doing it.” SPACE is unique because it focuses entirely on parent involvement and changing parental behavior—children are not involved in the sessions. For example, parents learn how to use supportive messages that convey confidence that their child can tolerate and manage distress. “It might sound like a parent saying to a child, ‘I get that this is really hard for you, but I know that you can handle it,’” Lebowitz says. The program also works with parents to identify the ways in which they are accommodating anxious behaviors. “We’ll pick one thing that parents are doing that is an accommodation and help them make a detailed plan for how they’re going to change that,” Lebowitz explains. Treating Anxiety in Children and Adolescents Much of the existing research on SPACE has focused on parents of children under age 14. Ongoing studies are now exploring its use with parents of older teens. “Both anxiety and accommodation can interfere with normative developmental shifts during the teen years, including increased autonomy and individuation from parents,” says Rebecca Etkin, PhD, associate research scientist in the Child Study Center. “In this sense, SPACE may be particularly well-suited for anxious teens and their parents. We want to see whether it is effective during this distinct developmental window.” Unfortunately, many families in need of CBT face barriers, including limited availability of services and geographic constraints. One way to improve access is digital interventions. Silverman and her team are developing an evidence-based digitized intervention program for parents that they can access directly from their computer or smart phone. “The work we’re doing will be one of the very few parent interventions that is digitized and importantly tested for effectiveness,” she says. Creating interventions for anxiety-related challenges Silverman and Lebowitz recently received a generous gift to develop and test other interventions that help parents reduce other child anxiety-related behavioral and emotional difficulties, such as restrictive eating and unexplained somatic symptoms. One of these projects in particular focuses on understanding the risks of social media and its potential benefits, including offering a sense of connection. “A lot of research has focused on the idea that social media is harmful and the less of it the better,” says Lebowitz. “But we actually see is that this is not quite right—there are negatives, but there are also positives. So, we’re trying to get a little bit more nuanced of a picture.” The team is working with teens with social anxiety and their parents over an extended period to better understand their social media habits and how their anxiety levels affect engagement with different platforms. The teens will answer questions sent to an app on their phones about mood and social media usage in an effort to capture emotional responses as they unfold. “We hope to develop interventions that can help make the best of social media while protecting against the more problematic effects,” Lebowitz says. The brain’s role in anxiety Researchers are also testing therapies to address anxiety at the neurological and molecular levels. In collaboration with Dylan Gee, PhD, professor of psychology in Yale's Faculty of Arts and Sciences, and Hilary Blumberg, MD, John and Hope Furth Professor of Psychiatric Neuroscience at Yale School of Medicine, Lebowitz and Silverman are using brain imaging to identify changes in a child’s brain before and after parents enroll in SPACE. In one study, children viewed anxiety-inducing images while undergoing magnetic resonance imaging (MRI); the researchers conducted scans with and without the children’s parents nearby. Before SPACE, children’s brains were better able to activate the regulatory circuitry needed to turn off an anxious response when their parents were nearby. But after SPACE, children could activate this circuitry even without the parent around. “As parents work on gradually reducing some of their accommodations, you can see a child get better at regulating their own fear system in the brain,” Lebowitz says. “It’s remarkable.” Research into the molecular underpinnings of anxiety can also inform new childhood anxiety treatments. In a recent study, Lebowitz, Silverman, and Flora Vaccarino, MD, Harris Professor in the Child Study Center, discovered that a protein known as fibroblast growth factor 2 (FGF2) could be protective from the toxic effects of stress. FGF2 levels in children and their parents were linked to the children’s risk of developing anxiety and depression, the study showed. The findings could help explain why some children who are exposed to early life trauma such as poverty or abuse are more prone to developing mental health disorders. And FGF2 could be a target for treatment. “This is very novel because it starts to give a clue to what is the molecular chain that connects those lived experiences to the actual psychological outcomes,” Lebowitz says. New ways to study and treat childhood anxiety Michael Crowley, PhD, associate professor in the Child Study Center, collaborates with Silverman and Lebowitz to study the role that attention plays in development and maintenance of childhood anxiety. There is a large body of research that shows that anxious children, like anxious adults, are prone to focus on threatening stimuli such as angry faces compared with neutral faces. This has led to innovative interventions that involve attention retraining. The idea is that if experts train children to look away from threatening stimuli, it may reduce their anxiety—especially children with social anxiety who are most prone to attend to threats. The researchers have just completed a clinical trial for attention retraining with 10- to 14-year-olds with social anxiety disorders and are currently analyzing the findings. Besides this innovative attention retraining research, as Crowly notes, “I like to design tasks that are engaging to kids,” Crowley says. “My goal is to assess something without the kids knowing what we are assessing.” With this goal in mind, Crowley has created a virtual game, named Boom, to study threat processing in children with anxiety disorders. The game is similar to that of hot potato—the child and three digital players take turns virtually passing a ball to each other’s gloves. At some point, the ball turns into a bomb, and as the bomb lands in each player’s glove, the outline of the glove turns yellow. The goal is to avoid having the bomb go off in your glove. What isn’t obvious is that the game is designed to measure different types of threatening stimuli, both ambiguous and direct. In the game, the direct threat occurs as the bomb is traveling towards your glove. The ambiguous threat is the yellow outlined glove as it is unknown where the bomb will travel next. While children play the game, Crowley’s team measures their brain activity using electroencephalography (EEG). The researchers have discovered that in kids with anxiety, the brain reacts more strongly to ambiguous threats than it does in their peers, but less strongly to direct threats. They believe that the initial abnormally large brain response to not knowing where the bomb is going impairs the brain's ability to properly respond when the threat is actually traveling the child’s way. “The brains of children with anxiety are unable to differentiate between threats you need to do something about and those that are not your problem.” Michael Crowley, PhD, develops innovative games for studying anxiety in children and adolescents.Credit: Matt Bradbury Based on these insights, Crowley hopes to study whether interventions like attention training could restore appropriate threat processing. Crowley’s team is also working on a test called the Balloon Risk Avoidance Task, which evaluates risk-taking and avoidance behaviors. It features a digital balloon that is full of air and about to burst. Kids have six seconds to let air out of the balloon. The more air they let out, the less risk they face that the balloon will pop. But at the same time, the balloon becomes less valuable as it deflates. “The more air you keep in the balloon, the more points you get,” Crowley explains. So far, the researchers have found that when the balloons pop unexpectedly, teens with social anxiety show distinct brain responses. Studying these responses can help psychologists understand the underlying pathways driving the various manifestations of anxiety. The genetics of anxiety When Thomas Fernandez, MD, associate professor in the Child Study Center and of psychiatry, was still in training, there was a lot of excitement about understanding the genetics associated with autism spectrum disorder. Since then, scientists have identified around 250 genes associated with autism. The genetic contribution to anxiety disorders, on the other hand, has historically received less attention. Anxiety is less heritable than autism, but the genetic contribution for anxiety disorders that emerge in childhood may be higher than for anxiety disorders overall. While scientists estimate the heritability of anxiety disorders in general to be around 30% to 50%, some studies suggest higher heritability for certain childhood-onset anxiety presentations. “I saw firsthand how researchers in the field went about finding vulnerability genes for autism,” Fernandez says. “So, we’re using a very similar playbook for childhood anxiety.” “I saw firsthand how researchers in the field went about finding vulnerability genes for autism. So, we’re using a very similar playbook for childhood anxiety.” Thomas Fernandez, MD Associate Professor In the Child Study Center and in Psychiatry Now, Fernandez and Emily Olfson, MD, PhD, assistant professor in the Child Study Center, are studying children and their parents to identify genetic changes that are present in the child but not the parents, known as “de novo mutations.” “All of us have some de novo mutations—maybe about 50 to 100 sprinkled throughout the genome,” Olfson says. “But when they occur within the coding regions of genes, they can be really disruptive.” Previous research shows that people with autism have higher rates of damaging de novo mutations than the general population. In 2022, Olfson, Lebowitz, Silverman, and Fernandez published a study on 68 children and their families that found that children with anxiety had similarly high levels of these mutations. Studying de novo mutations can help point the researchers to where they should be looking for genes associated with anxiety. “The end game is using the genes to steer us toward the right part of biology that we can then target to come up with better treatments,” Fernandez says. Building on those findings, the team is now studying more families to better understand how these de novo mutations, along with other genetic and environmental factors, shape pediatric anxiety disorders. They recently received a National Institutes of Health grant to enroll 750 new families over the next five years. Olfson is the principal investigator, with co-investigators Lebowitz, Fernandez, Silverman, and Shuangge Steven Ma, PhD, department chair and professor of biostatistics at Yale School of Public Health. Neurodevelopment, Risk Genes, and Mental Health Conditions - The Olfson Lab Joel Gelernter, MD, Foundations Fund Professor of Psychiatry, is interested in how different anxiety disorders differ genomically. “We are studying social phobia, panic disorder, and generalized anxiety disorder, working to understand why people differ in their risk to these specific anxiety disorders and evaluating various risk factors,” he says. Gelernter was recently involved in one of the largest studies to date of the genomics underlying anxiety disorder. The study included around 122,000 people with anxiety disorders and around 730,000 without. It found that some genetic differences associated with anxiety were linked to signaling that helps reduce overactivity in the nervous system. Many anxiety medications available today work by targeting this process. “It’s nice when the biology that you get out of a large genome-wide study ratifies things that we already know because that can help increase confidence in further findings from the study,” Gelernter says. Uncovering the neurobiology of psychiatric disorders John Krystal, MD, Robert L. McNeil, Jr. Professor of Translational Research and chair of the Department of Psychiatry, is interested in the neurobiology of psychiatric disorders, including post-traumatic stress disorder (PTSD), of which anxiety is a major symptom. In the late 1980s, Krystal’s team discovered that the drug yohimbine activated symptoms in patients with PTSD. “This was the first time we could link a specific biological mechanism to the symptoms of PTSD,” Krystal says. At the time, he adds, this finding was highly controversial. “A lot of people felt that PTSD was a purely psychological syndrome that didn’t have an underlying biology.” Since then, Krystal has dived deep into understanding the neurobiology of PTSD to learn how to better treat it. His team is evaluating the use of ketamine and psychedelics. These would be among the first treatments to be developed specifically for PTSD. They may also be applicable for other disorders including anxiety disorders, Krystal adds. An important gap in PTSD treatment is the absence of biological tests that inform how to best help patients manage their PTSD symptoms. A doctor doesn’t diagnose cancer based on how they feel. Rather, they use tests of the biology of the cancer to determine the best course of treatment. “And we can’t do that in any psychiatric disorder other than Alzheimer’s disease,” Krystal says. “But now we are building a foundation for this approach to the treatment of anxiety disorders for the first time.” Source: Yale School of Medicine
Bob Kustra and Jenny Kustra-Quinn: The time for keeping beluga whales captive for our entertainment has passed
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49ers Handed Intriguing Take on Vita Vea After Defeating Broncos
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George Kittle keeps moving up the 49ers record books.
Colorado football's quarterback carousel keeps going round and round
Deion Sanders struggles to find a consistent signal-caller as schematic failures and shifting offensive identities force another benching, leaving the Buffaloes searching for a desperate spark against Utah.
76ers' Scrimmage Shows Fans There’s Plenty To Be Excited About
The Philadelphia 76ers had a scrimmage that showed some flashy highlights. But, there's some important things that happened that should keep everyone in high spirits.
At San Francisco General, researchers are learning how to control HIV without drugs
Doctors at San Francisco General Hospital's famed AIDS clinic have shown the immune system can be primed to keep the virus in check — a promising advance just as U.S. funding cuts threaten future research.
Pakistan: Imran Khan supporters demand ex-PM's release
Thousands of Imran Khan supporters have begun a trek to Islamabad to demand he be freed as Pakistan's political leadership remains in deadlock. The government has set up roadblocks to keep protesters at bay.