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Trapped by his own image: Trump’s Iran War and the politics of ego
The judgment on the Trump administration’s war on Iran is already largely settled across mainstream media, public opinion, and much of the analytical sphere.
Google battles Chinese open-weights models with Gemma 4
: Now with a more permissive license, multi-modality, and support for more than 140 languages
Microsoft shivs OpenAI with three new AI models for speech and images
: About that partnership...
Research points to brain-based clues for mental health
In a split second, the brain determines whether an ambiguous situation is good or bad—and those snap judgments can reveal important information about a person. A new article by Husker psychologist Maital ...
Even Microsoft knows Copilot shouldn't be trusted with anything important
: Terms admit it is for entertainment only and may get things wrong
Publicis sharpens sports marketing focus with 160over90 acquisition
Publicis CEO Arthur Sadoun described sports as the firm’s “next big bet” as it tries to bring cohesion to an increasingly valuable but fragmented market.
Central banks' inflation mood puzzle: more judgment than science
The world's central bankers may be attempting the impossible: to get into the psyche of business executives, labour unions and ordinary households in real time to understand how they are navigating their finances through yet another energy shock.
A Look At Live Nation Entertainment (LYV) Valuation As Concerts Hit Records And Global Expansion Accelerates
Why Live Nation’s 2025 milestones have investors’ attention Live Nation Entertainment (LYV) is back in focus after reporting record adjusted operating income in its Concerts segment for 2025, hosting 159 million fans and outlining new venue openings across Latin America, Europe, and the U.S. See our latest analysis for Live Nation Entertainment. Live Nation’s latest results arrive after a 7.11% 90 day share price return and a 13.35% 1 year total shareholder return, which build on a very large...
Neta’s research points to brain-based clues for mental health
In a split second, the brain determines whether an ambiguous situation is good or bad — and those snap judgments can reveal important information about a person. A new article by Husker psychologist Maital Neta suggests that these responses, known as valence bias, could help identify risk factors for depression, anxiety and other stress-related conditions.
We know what day it is but these Raspberry Pi price hikes are no joke
: Who is going to drop nearly $400 on an underpowered Linux computer?
Trump’s Iran War and the Politics of Ego
The judgment on the Trump administration’s war on Iran is already largely settled across mainstream media, public opinion, and much of the analytical
Maine business leaders speak out against data privacy bill
Business leaders gathered in Portland Tuesday to speak out against a data privacy bill in Augusta.
Microsoft reaches for yet another out-of-band patch to deal with latest update issue
: Weren't these supposed to be 'atypical'?
Predicting spring bloom is an art
Do you ever wish you could predict the future? The National Park Service in Washington D.C. does it every year when they forecast when the Capitol’s cherry blossoms will reach peak bloom. People travel from all over the world to enjoy the annual National Cherry Blossom Festival and to glimpse these fragile flowers before they are gone. On this month’s Nature Quest, we learn the ins and outs of cherry tree blossoms, how scientists make that big prediction every year — and why all this focus on blooms can help scientists better understand climate change. This episode is part of Nature Quest, our monthly segment from listeners noticing a change in the world around them. To participate, send a voice memo to shortwave@npr.org with your name, location and your question about a change you're seeing in nature!Want to learn more about nature’s calendar? Check out our first Nature Quest episode on whether flowers are blooming early.Listen to every episode of Short Wave sponsor-free and support our work at NPR by signing up for Short Wave+ at plus.npr.org/shortwave.
GitHub backs down, kills Copilot pull-request ads after backlash
: Letting Copilot alter others' PRs was the wrong judgment call, says product manager
Lawsuit claims Maine transgender sports referendum signatures are not valid
The lawsuit was filed by Jane Gilbert, Mark Sayre and Kaitlin Webber in Cumberland County Superior Court on Friday.
A Nurse Educator on Resilience, Patient Care and the Future of Health - Newsroom | University of St. Thomas
Faculty member Dr. Vane Gichana brings a blend of clinical judgment and critical thinking when she instructs nursing students at St. Thomas.
Is an IDA Health Window the Global Health Financing Solution?
The global health architecture is facing intense scrutiny. There are now an A-Z of initiatives launched to lead the reform, from the Accra Reset to the Lusaka Agenda Secretariat and a WHO-led process. Critics have argued that the current system fails to focus on the poorest countries, fragments national systems, undermines country ownership, and displaces domestic health spending.
AKC Canine Health Foundation Joins All Access hosted by Andy Garcia to Explore the Science of Veterinary Innovation
The AKC Canine Health Foundation (CHF) is excited to announce a collaboration with the educational program "All Access hosted by Andy Garcia" to develop a documentary segment centered on canine health research. Set to film on April 15, 2026, at the Foundation's headquarters and the North Carolina State University College of Veterinary Medicine, the production will provide an objective look at how independent research improves the well-being of dogs, through highlighting CHF's pivotal role as a f
Will a Fragmented Electorate Undermine Black Political Strength?
Crowded primaries could signal a weakening of African American political power, but a more open and competitive political environment could also be a sign of democratic health.
Business owners say late notice of protest caused confusion along Montgomery
ALBUQUERQUE, N.M. (KRQE) – As protesters marched through northeast Albuquerque on Saturday, several nearby businesses say they felt left in the dark about when — or if — roads would be shut down. M…
Tyler Sloat Joins Hinge Health Board As Growth And Discipline Focus
Hinge Health (NYSE:HNGE) appointed Tyler Sloat to its board of directors, adding a leader with experience in high growth technology companies. Sloat has held senior roles at companies that have gone through rapid expansion and IPOs. The appointment signals a focus on scaling Hinge Health's business and strengthening governance as the company matures. Hinge Health focuses on digital musculoskeletal care, a segment that sits at the intersection of healthcare and technology. As employers and...
Scientists mimicking the Big Bang accidentally turn lead into gold
The physicists made an unexpected breakthrough
The geography of science
Scientific activity has historically been concentrated in a small number of advanced economies, but the global landscape of research is undergoing rapid transformation. Using data on 44 million publications from 1980 to 2022, this column examines how the geography of science has evolved along three dimensions: where research is produced, what topics it studies, and where it is consumed through citations. It documents a substantial shift in scientific production from traditional Western leaders s emerging economies. Yet scientific attention and knowledge diffusion remain uneven, revealing a tension between the global expansion of scientific capacity and the continued fragmentation of the knowledge system.
Business groups warn Maine data privacy proposal could raise marketing costs, hurt growth
The Maine State Chamber of Commerce is urging CEOs and senior executives across the state to join its opposition.
Maine Science Teacher Prepares for NASA’s Summer Mission
BRUNSWICK (WGME) -- Karin Paquin, a science teacher at St. John’s Catholic School in Brunswick, is about to prove that her teaching skills are truly out of this
Portland kayak business searching for alternative locations after devastating wharf fire
Portland's Custom House Wharf is still months away from being rebuilt after this winter's devastating fire.
Anthropic tweaks timed usage limits to discourage Claude demand during peak hours
: AI biz makes some Claude conversations more costly to manage capacity
AMD’s new desktop CPU oozes cache out of all 16 cores
: Turns out massive caches are good for more than games. House of Zen boasts 5-13% perf boost over prior-gen part
GitHub hits CTRL-Z, decides it will train its AI with user data after all
: As of April 24 you'll be feeding the Octocat unless you opt out
Portland Planning Board rejects proposed buffer between entertainment venues
A proposed buffer that would determine the distance between large music venues is sparking controversy in Portland Wednesday night.
‘Girlypop Politics’ takes civics education to the airwaves
The host of the Salem-area radio segment aims to demystify how local government works, and encourages listeners to get involved
Augmenting citizen science with computer vision for fish monitoring
Monitoring river herring migration is essential for conservation and fisheries management. Researchers have now demonstrated a method using video and computer vision to supplement traditional methods and volunteer-based programs.
Madeline Shepley on the Wonders of Faith and Science
Madeline Shepley discusses sharing the wonder of the universe with kids, her role as a Catholic scientist, and her love of science fiction.
Verdict on chatbots in mental health screenings? Too judgmental
Chatbots used in mental health screenings aim to reduce the stigma associated with seeking help and to expand access to needed services. Because they cannot cast personal judgment, chatbots are considered ...
Neal Stephenson, who coined the term ‘metaverse’, says head-mounted VR hardware will never happen
: ‘People don’t like wearing things on their faces and don’t trust those who do’
Segment: Financing Action on Extreme Heat and Maternal and Newborn Health: The Way Forward
The segment “Financing Action on Extreme Heat and Maternal and Newborn Health: The Way Forward” will examine how innovative and better-aligned financing approaches can respond to these growing risks. Discussions will highlight country experiences in mobilizing domestic resources, opportunities to unlock and scale climate finance, and the role of heat-smart innovations in building resilient health systems. Particular attention will be given to low- and middle-income countries, where exposure and vulnerability remain highest, and where integrated solutions can deliver the greatest impact.
Small swings, high drama: why UK polls are less volatile than they seem
In what is beginning to look like a fragmented five-party system, small swings carry outsized political consequences
Microsoft: Removing some Copilots will improve Windows 11
: 'Doze boss admits OS needs smaller memory footprint, fixes for old issues like bad Bluetooth, more prominent WSL
Your Thymus and Your Healthspan
Our thymus gland plays a central role in the development or our immune system, specifically for supporting T cell development (how these cells got their name, maturation and differentiation in the thymus) and discriminating between self and foreign, non-self antigen proteins with production of dendritic cells. As we age, our thymus gland shrinks—the process known as involution—with progressive change from spongy to fatty tissue, with loss of functionality. But this process, with respect to timeline and extent, markedly varies from one person to the next. And to make things even more complicated, our thymus gland anatomy and precise location in the chest also is highly variable. So the famous Frank Netter diagrams from the 1960s (such as at left below) don’t capture the remarkable heterogeneity that a random set of 12 chest CT scans (below at right). What I consider as 2 landmark papers in Nature this week (here and here) used AI to quantify health of the thymus in 2 large cohorts, and then correlate the metric to a broad array of health outcomes. In this edition of Ground Truths, I’m going to cover three questions: (1) How was thymus health determined by AI?; (2) How is thymus health linked to key clinical outcomes? and (3) Are there ways we can promote a healthy (aka rejuvenate) thymus gland in our later years? Subscribe 1. How was thymus health determined by AI? This was accomplished by extensive work developing and validating an AI pipeline for 2 stages, the first for localization and segmentation of the thymus bed, and the second to quantify a digital marker, termed the thymic health score. There’s a lot to this algorithmic development, so I won’t go into all the details, but just provide a rudimentary outline of what was done. The 1st stage used supervised learning with 2 radiologists reviewing 2,461 chest CT scans. That work trained a 3D U-Net model to automatically identify the thymic bed’s 3D cropped region using center of mass coordinates, which reached 99.8% accuracy. The 2nd stage used a foundation model that was pre-trained with SwAV (which stands for Swapping Assignment between multiple Views), a self-supervised model, that generated a high-dimensional thymus representation of 4,096 features. That compares to the radiology reductionist and subjective scoring of 0 to 3 where 0 means the thymus is fully degenerated and fatty, and 3 is considered dense, intact glandular soft tissue. Notably, the self-supervised learning (SSL) performance was superior to supervised (AUC ~0.75 vs 0.55, respectively) reflecting the shallowness of the 0-3 classifier vs SSL’s holistic, self-taught AI. The thymic health score ranged from 0 to 100, with the highest number indexed to fully preserved thymic health. The algorithmic work extended to explainability with both Shapely value distribution, meaning the model was holistic not relying on any “magic” pixel, and occlusion sensitivity, demonstrating the model’s performance was not affected by ribs, sternum, lung tissue, but rather focused on the thymic bed directly. Below are a few saliency maps from the occlusion sensitivity that indicate the thymic bed focus, not affected by neighboring structures, using the jet color scale. Now the AI was ready for processing ~25,000 CT scans, each over 30 MB files, from the 2 large participant cohorts to provide a thymic health score, it did so in less than 14 hours, which is less than 2 seconds per scan! Share 2. How is thymus health linked to key clinical outcomes? The two cohorts were the National Lung Screening Trial, NLST (N=25,031) and the Framingham Heart Study, FHS (N=2,581) each with baseline demographics and long term follow up of >12 years for health outcomes. From the NSLT, you can see below that increased age and body-mass index were correlated to reduced thymic health. And, overall, men had reduced thymic health scores compared with women. There are a lot of graphs in the paper for outcomes, for both the NLST and FHS cohorts. To simplify the major outcomes, below is a composite Figure with striking reduction of all-cause mortality and for the different causes of death. The results were consistent between the 2 cohorts. For example, the cardiovascular mortality hazard ratio average was 0.57 in NLST and 0.38 in FHS (weighted to be 0.53 for the aggregate). The reduction of mortality also extended to digestive diseases and pulmonary disease (data not shown below). Lung cancer incidence was reduced by 36% for high vs low thymic health (Figure below, with a panel -incidence and b panel-mortality, adjusted for age, sex, BMI, smoking status). Notably, there was a smoker’s paradox: lower incidence and improved survival for lung cancer in smokers who had a high thymus health score. Smoking was associated with lower thymic scores whereas alcohol was not. Higher thymic health was linked to higher HDL cholesterol, lower triglycerides, lower fasting blood glucose, and lower systolic and diastolic blood pressure. Inflammation biomarkers, such as C-reactive protein and interleukin-6, were elevated in the people with lower thymic health scores. In their second paper, the same team looked at the relationship between thymic score and outcomes for 3,476 patients receiving cancer immunotherapy. The non-small cell lung cancer progression-free survival was reduced in patients with low thymic health score. A parallel relationship for survival was seen for other types of cancer including melanoma, breast, and kidney with a 44% lower risk among high thymic scores (Figure). A similar pattern was seen with different immune checkpoint inhibitors. The thymus health score outperformed programmed death ligand-1 (PD-L1)and tumor mutation burden (TMB) assay of the tumor and was an independent prognostic marker of progression-free survival. In this dataset, a direct connect with thymus score and adaptive immune function was noted with a correlation before cancer treatment for both T-cell diversity and thymus T-cell production (a metric known as T cell receptor excision circles). Thymus Removal Study There is a highly relevant citation about thymus function before moving onto ways to rejuvenate it. In 2023, a very important study of thymus removal during cardiothoracic surgery was published, with 1146 patients undergoing thymus removal vs 1146 matched controls (mean age 55 years). The adverse outcomes for thymus removal were striking, with a 2.9 higher risk of all-cause mortality and doubling of cancer incidence, 1.5 fold increase in cancer mortality, and 1.5-fold increase in autoimmune diseases. The immune function showed marked compromise after thymus removal, as reflected by CD4+ and CD8+ T cells (Figure below) Share Ground Truths 3. Are there ways we can promote a healthy (aka rejuvenate) thymus gland in our later years? In recent months we’ve learned a lot about the process of thymus involution and the pathways by which this may be modulated. Thymus involution is primarily due to loss to thymus epithelial cells (TECs) and there are 2 subtypes with different functions: the cortical, responsible for positive selection of T cells, and the medullary, for negative selection. When adipose tissue infiltrates the thymus, thymic adipocytes are pro-inflammatory, knocking out T-cell output. Likewise, systemic inflammation, or “inflammaging,” from smoking, obesity, and chronic stress promote thymic adipocytes. Now, from preclinical studies, we know about key pathways that account for these processes. Historically, back in 2014, FOXN1 was recognized as a single master transcription factor essential for TEC function, with studies in mice with forced FOXN1 upregulation leading to thymus regeneration. That laid the foundation for potential regrowth of quiescent thymus cells. It took awhile to find pathways to accomplish this goal and to even refute its role as the master regulator. The Liver-Thymus Axis Feng Zhang and his team recently showed that injection of an mRNA vaccine to the liver encoding DLL1, IL-7 and FLT3-L in combination, factors known to support thymopoiesis (Figure), successfully enhanced immune function in aged mice. However, the effect was transient. The FGF21 Story Two reports in 2025 addressed the thymus gland’s production of FGF21, a growth factor (fibroblast growth factor 21) and its control of thymus involution. This growth factor is also produced by the liver, but it doesn’t have impact on the thymus in aged rodent models. In contrast, The liver’s hepatocyte growth factor (HGF) has been shown to reverse senescent TEC structural changes. Growth hormone stimulates production of insulin growth factor-1 (IGF-1) in the liver and the thymus. Two small studies in human participants (TRIIM, for Thymus Regeneration, Immunorestoration, and Insulin Mitigation) of 6 and 50 people, respectively, treated with combined human growth hormone, metformin and DHEA, suggested the potential of slowing epigenetic aging and improving thymus mass and function. But the combination of drugs, small sample, and lack of controls make conclusions murky. Increased thymus FGF21 led to increased CD8 T cells in old mice and extended healthspan and improved physical performance. Building on the previous FOXN1 data, ablation of β-klotho, the obligatory co-receptor for FOXN1, accelerated thymic aging. The benefit to FGF21 was confirmed in a companion paper using an FGF21 knock-in mouse model showing thymus enlargement and increased TECs throughout the lifespan. (schematic Figure below). The accompanying editorial for these 2 papers speculated: “The proposed link between age-associated thymus involution and organismal aging is intriguing, and suggests we might seek to achieve systemic rejuvenation by counteracting thymic involution.” Other Factors Lessons from the Axolotl (Mexican Salamander) In an elegant set of experiments of the axolotl (Figure), known for its complete thymus regeneration after total surgical removal, mediators were identified. Surprisingly FOXN1 was dispensable. But midkine, a growth factor, appeared to be the driver, the initiator of thymus cell growth, survival, and repair. Other components that contributed were Postn+ (periostin-expressing mesenchymal niches) and Ccl19, a chemokine protein from the bloodstream. RANK and RANKL RANK (receptor activator of nuclear factor κB its ligand (RANKL) have been considered key regulators of medullary TECs. In a study of both aged mice and human thymus cell cultures, their key role was confirmed, with multiple benefits of resorting TEC function, recruitment of progenitor cells, and T cell development. Subscribe Summing Up This body of work strongly supports the health of the thymus gland as a critical regulator of human healthspan, not just a correlate or link. The new landmark studies are reinforced by the regenerative biology experimental models that have shown, via an array of mediators, that healthspan of aged mice is at least in part dependent on thymus gland function and its critical role for maintaining adaptive immunity. It sure seems that we’d be better off having an immune reservoir of naive T cells instead of a profile in older adults of exhausted, low quality, memory T cells, with a senescent phenotype. It is striking that we ignored the importance of the thymus gland for many decades. A wake-up call was the results of the thymectomy matched control study reviewed here, with the opposite of high thymic health score improved health outcomes. The convergence of AI and healthspan here is notable. The exceptional and laborious work for developing and validating (no less explaining) the AI to quantify thymus health set the foundation for probing the connect the major health outcomes in two cohorts with extensive follow-up. We’ve never had a way to meaningfully quantify the thymus gland before, so this represents important leverage of supervised, self-supervised, and transformer models. The study wouldn’t have been possible without AI. And it begs the question as to whether there are ways we can maintain our thymus at a high health score. But it’s not so simple to rejuvenate our thymus. There are multiple risks including the induction of autoimmunity, increasing the risk of cancer, and inducing a pro-inflammatory state. For example, factors that increase TEC proliferation could compromise the medulllary negative selection process and leak out auto-reactive (self-attacking) T cells. Thymic cells could be induced to proliferate, but we know, for example, that growth hormone and IGF-1 are associated with an increase risk of cancer. If thymus rejuvenation doesn’t clear out the accumulated senescent cells in older adults, then inflammation within the gland could block the production of TECs. Keeping these risks in mind, we now have identified many ways to keep our thymus healthy as we age that undoubtedly will be tested in clinical trials going forward. Ultimately, the benefit-to-risk tradeoffs will be defined. In the meantime, we have desperately needed an immunome. As I’ve stressed in multiple prior Ground Truths, we have no test in the clinic to assess a patient’s immune status! It was very encouraging for me to get an email from Hugo Aerts, the senior author of the landmark papers in the days after they were published: “I also wanted to say that your Substack on “Why We Need an Immunome” was inspiring for this work. We found it a very compelling perspective and greatly enjoyed reading it.” Just having an assessment of a person’s immune status via a chest CT scan, with millions of these performed per year, might help in guiding the right immunotherapy for cancer (e.g. more intensive, combinations for those with low thymic health scores) and help define people who are increased risk for age-related diseases of cancer, cardiovascular, and neurodegenerative. The main theme of Super Agers is that we now have many layers of data (genetics, proteins, biomarkers, organ clocks that can be integrated via multimodal AI) for us to define a person’s specific risk decades before one of these age-related diseases leads to symptoms, enabling prevention. From the new studies this week, we can add thymus health score as yet another way to understand a person’s risk, a window into their adaptive immune system and healthspan. And perhaps someday we will be able to safely rejuvenate the thymus, or maintain its health through one’s life, and use the thymus health score to monitor. NB: I wrote this post (No A.I.) A Quick Poll Loading... ********************************************************************* Thanks to Ground Truths subscribers (now > 200,000) from every US state and 212 countries. Your subscription to these free essays and podcasts makes my work in putting them together worthwhile. Please join! If you found this interesting PLEASE share it! Share Ground Truths Paid subscriptions are voluntary and all proceeds from them go to support Scripps Research. They do allow for posting comments and questions, which I do my best to respond to. Please don’t hesitate to post comments and give me feedback. Let me know topics that you would like to see covered. Leave a comment Many thanks to those who have contributed—they have greatly helped fund our summer internship programs for the past two years. It enabled us to accept and support 47 summer interns in 2025! We aim to accept even more of the several thousand who will apply for summer 2026.
This CEO took legal advice from ChatGPT to avoid paying $250 million bonus. It backfired
The court stressed that company executives are expected to exercise independent judgment, not outsource good-faith decisions to an AI.
How do I share a mental health diagnosis? | The therapist is in
Is there a way to share a mental health diagnosis but shield myself from hurt or judgment? How can I do it without changing a relationship?
Science news this week: Super El Niño looms, an Acropolis marble fragment resurfaces, and a pure hexagonal diamond is born
March 21, 2026: Our weekly roundup of the latest science in the news, as well as a few fascinating articles to keep you entertained over the weekend.
Maine health officials encourage parents to protect babies from RSV
Cases of RSV are hanging around longer than usual this year.
Sorry, Amazon, you couldn't pick a worse time to bring a phone to market: IDC analyst
: The market is contracting
Verdict on Chatbots in Mental Health Screenings? Too Judgmental
Chatbots used in mental health screenings aim to reduce the stigma associated with seeking help and to expand access to needed services. Because they cannot cast personal judgment, chatbots are considered a neutral option for sharing mental health concerns. In a recent test of these common assumptions, however, a University of Texas at Dallas researcher […]
New dispute emerges around Subnautica 2’s early access release
Lawyers for the ousted—and now partially reinstated—leadership team of Unknown Worlds, the studio behind Subnautica 2, are crying foul over news that the game will be released into early access in May. The release announcement earlier this week was made improperly, potentially “damaging the game and sowing additional confusion among the Subnautica community,” the lawyers said in a letter sent on Tuesday to Vice Chancellor Lori Will of Delaware’s Court of Chancery. In their letter, the lawyers also floated the idea of asking Will to find Krafton in contempt of the court’s ruling. The letter was sent just one day after Will’s bombshell ruling that publisher Krafton had breached its contract with Unknown Worlds’ executive team, when it fired them last June. The new issue isn’t necessarily the May early access timeframe, but how the news was announced. The letter and Krafton’s response have not been previously reported. A quick recap of prior events: Subnautica 2 is an unreleased, underwater survival adventure and the most-wishlisted game on Steam. Last year, longtime Unknown Worlds CEO Ted Gill, along with studio co-founders Charlie Cleveland and Max McGuire, were fired by Krafton. They swiftly sued, saying the publisher had terminated them to avoid paying out up to $250 million in potential performance-based bonuses. The studio leaders had hoped to earn that with an early access release of the game, which Krafton had blocked. The publisher argued in court that Subnautica 2 wasn’t ready, which the ousted execs disputed. On Monday, Will ruled that Krafton had violated its contract, firing the execs to avoid the performance payouts, and that it had to reinstate Gill and give him full authority over any early access release for Subnautica 2. On Tuesday, IGN reported on a new memo issued that day to Unknown Worlds staff by Steve Papoutsis, the executive Krafton had put in charge of Unknown Worlds after the 2025 firings. In the note, Papoutsis said that Subnautica 2 had passed a key development milestone “last week” and that he and Krafton had determined the game “is ready for Early Access release in May.” This news appeared to catch the lawyers for Gill, Cleveland and McGuire by surprise. On Tuesday night, they sent a letter to Will expressing “serious concerns” about whether it would be possible to forge an agreement with Krafton consistent with the judge’s order. Papoutsis’ memo was a problem, they wrote. He didn’t have the authority to declare anything about Subnautica 2’s release. As of 9am ET on Monday, March 16, the effective date of Will’s order, Papoutsis wasn’t CEO of Unknown Worlds. Gill was. And, per Will’s order, only Gill could make Subnautica 2 release decisions. They continued: Krafton self-servingly announced the launch without any regard to its impact on the game, the team, or the community—let alone this Court’s Opinion. Announcing the release of a game is momentous, and it is typically accompanied by significant marketing activity, fanfare, and community coordination. And most importantly, the announcement is carefully designed to maximize excitement for the game. That entire process was supposed to be driven by Mr. Gill. However, in defiance of the Court’s Opinion, Krafton has now taken that away, further damaging the game and sowing additional confusion among the Subnautica community. The lawyers speculated that Krafton had “intentionally leaked” Papoutsis’ memo and then issued an official statement to confirm the leak. Game File is a reader-supported publication. My reporting is only possible through support from readers like you. To support my work, consider becoming a free or paid subscriber. Subscribe On Wednesday, lawyers for Krafton defended their client in their own letter to vice chancellor Will, saying nothing they did violated her order nor showed contempt: Papoutsis’s message was simply celebrating the UW employees’ efforts toward a past event: Krafton’s pre-Opinion determination that Subnautica 2 was ready for Early Access release. There was nothing improper about conveying the results of the milestone review or thanking the development team for their dedication and talent. They added that Gill could still make his own call about Subnautica 2’s release: In his role as CEO, Gill will be able to assess independently his views on the state of Subnautica 2 and the appropriate release schedule; nothing in Papoutsis’s message alters Gill’s authority or discretion. Vice chancellor Will has not responded to the letters and doesn’t necessarily have to. Both parties were previously ordered by Will to confer this week and submit a proposed judgment consistent with her ruling. The letter from Gill’s attorney’s this week doesn’t indicate whether he would or would not support a May release for Subnautica 2. But it could limit his options. And, if Gill’s lawyers are right, the lack of marketing fanfare around the leak of the May date could dull the launch of the game. Any harm to Subnautica 2’s launch is an extra sensitive issue given the context of the legal dispute: millions of dollars of payouts are on the line, tethered to the scale of the game’s initial performance. In her ruling on Monday, Will noted that there was obvious “bad blood” between Gill’s side and Krafton but that the two would need to work together: “They can—and must—act in good faith to navigate their remaining contractual relationship.” Item 2: A new kind of couch co-op game A highlight of GDC each year is the Alt.Ctrl showcase that features games played with extremely experimental controllers. Perusing this year’s offerings last Friday, I found a game controlled with giant scissors, another with big toothbrushes and one that amounted to dumpster diving. My favorite was Pivot, a co-op game about collectively maneuvering a couch. It was developed by students at the University of Utah’s masters of arts and engineering games program. Players lift and tilt the physical couch in order to control the position of a virtual one. That virtual one is moving through an obstacle course on-screen, while being pursued by a giant skull. Developer Nishant Verma told me at GDC that the couch is made of styrofoam (this became more evident as I watched!) and that the name was a riff on an episode of the sitcom Friends. Item 3: In brief… 🚫 Ubisoft is laying off more than 100 workers at its Red Storm studio, as the North Carolina location known for decades for its Tom Clancy games, ceases in-house game development, VGC reports. 👀 On Monday, Nvidia’s revealed its DLSS 5 AI-driven graphics technology that purports to improve game graphics… and it has been roasted about it by the media and the online gaming public for the remainder of the week. The tech changed the faces of characters in footage from Resident Evil Requiem, Hogwarts Legacy and EA Sports FC, drawing accusations of giving carefully art-directed games the generic look of AI “slop.” Nvidia CEO Jensen Huang had said on Monday that “DLSS 5 is the GPT moment for graphics—blending handcrafted rendering with generative AI to deliver a dramatic leap in visual realism while preserving the control artists need for creative expression.” By mid-week, Huang was telling Tom’s Hardware that the new tech’s critics were “completely wrong” because game-makers could still “fine-tune the generative AI” to suit their game’s aesthetics.
Del Monte Foods Successfully Completes Sale Transactions Across All Business Segments
/PRNewswire/ -- Del Monte Foods Corporation II Inc. (the "Company" or "Del Monte Foods"), a leading producer, distributor, and marketer of premium quality,...
Google gives Android users a way to install unverified apps if they prove they really, really want to
: Chocolate Factory describes concession as an attempt to balance openess with safety
Trump launches investigation of states that mandate health insurance covers abortion
The states with the coverage requirements include California, Maine, Massachusetts, New York, Vermont, and more.
General Mills offloads Brazil business as sales dip
The Golden Valley-based food company posted profit lower than Wall Street’s expectations, and this latest divestiture will help it focus on pet food and other growing segments.
Maine gubernatorial candidates outline health care visions
The Democratic and Republican primaries are set for June 9 and the general election is set for November 3.
Fragmenting Comet C/2025 K1
This animation steps through the three Hubble images of the fragmenting comet C/2025 K1 (ATLAS), or K1, taken on Nov. 8, 9, and 10, 2025.
Microsoft 365 pauses Copilot creep after admins cry foul
: Automatic deployment of Redmond's assistant halted for now
Leadership Team for Expanded Disney Entertainment Segment | The Walt Disney Company
Dana Walden, incoming president and chief creative officer of The Walt Disney Company, announced the new leadership structure for Disney Entertainment.
‘Grey’s Anatomy’ creator addresses Eric Dane Oscars controversy
“Grey’s Anatomy” creator Shonda Rhimes disagrees with fans upset that Eric Dane was excluded from the “In Memoriam” segment of the 98th Academy Awards.
AI still doesn't work very well, businesses are faking it, and a reckoning is coming
interview: Codestrap founders say we need to dial down the hype and sort through the mess
Volvo Construction Equipment announces closure of Rokbak business
As part of a long term strategic shift and due to the unsustainable profitability of the Rokbak business Volvo Construction Equipment (Volvo CE) will close its Rokbak business and concentrate resources on its portfolio of other hauling solutions. The business had revenues of SEK 1.0 bn in 2025 and was loss-making. The closure of the business will negatively impact operating income by about SEK 0.7 billion in the Construction Equipment segment in Q1 2026 and will be reported as an adjustment. About SEK 0.4 billion refers to non-cash items with the majority related to goodwill impairment.
Nvidia's DLSS 5 promises to bring you out the other side of the uncanny valley
GTC: The latest generation of Nvidia’s AI image enhancer brings characters to life
The Walt Disney Company Sets Leadership Team for Expanded Disney Entertainment Segment
BURBANK, Calif., March 16, 2026--Dana Walden, incoming president and chief creative officer of The Walt Disney Company (NYSE: DIS), today announced the new leadership structure for Disney Entertainment, bringing together the company’s streaming, film, and television businesses along with its growing games and digital entertainment division. Consumers today want to engage with Disney’s storytelling and characters in a multitude of ways – whether on Disney+, in theaters, or through the digital gam
Black women lead fastest-growing segment of US entrepreneurs
Black women are launching businesses at a faster rate than any other demographic in the U.S., driven in part by layoffs, stalled promotions and a corporate environment many say feels increasingly inhospitable, The Wall Street Journal writes. The number of Black women-owned businesses rose about 13% last year, according to research from Wells Fargo and […]
Bombshell judgment demands Krafton immediately reinstate ousted CEO and return his authority over Subnautica 2
In a bombshell ruling, a court has ordered Krafton to reinstate former Unknown World CEO Ted Gill, return control of th…
Kering adapts the presentation of its businesses, to align with its strategic model and organization
Kering - Press release - Segment reporting - EN - 16 03 2026 PRESS RELEASEMarch 16, 2026 KERING ADAPTS THE PRESENTATION OF ITS BUSINESSES, TO ALIGN WITH ITS STRATEGIC MODEL AND ORGANIZATION As part of the evolution of its strategy and organization, which will be presented in detail on April 16, 2026, during its Capital Markets Day, Kering announces a new segmentation of its businesses. This new presentation enhances the clarity of Kering strategic model, highlights the momentum of each of its bu
EHR fragmentation offers an opportunity to enhance care coordination and experience
Harmonizing electronic health record platforms and their legacy data tames complexity and enables easier patient access to information and greater patient trust in the healthcare system, says NewYork-Presbyterian's EHR manager.
SKF announces new business segments and releases restated figures
SKF today announces the introduction of a new segment reporting structure, effective from Q1 2026. The purpose of these changes is to reflect the Group's strategic focus and to provide increased transparency ahead of the planned separation of the Automotive business. SKF is also publishing restated financial information for the new segments for 2024 and 2025.
Why Gene Hackman wasn't featured in the 'In Memoriam' segment at the 2026 Oscars
The 2026 Oscars didn't include Gene Hackman in its 'In Memoriam' segment on Sunday. Here's why.
Africa’s Business Aviation Rebirth
Africa's business aviation sector has lived under the weight of a stubborn global stereotype: a continent defined by ageing aircraft, fragmented regulation and limited economic prosperity.
What are WSJ’s entertainment reporters watching for?
“I’m looking forward to seeing the tribute segment to [Rob Reiner](https://www.wsj.com/arts-culture/film/rob-reiner-director-of-this-is-spinal-tap-when-harry-met-sally-dies-at-78-10f173d4?gaaat=eafs&gaan=AWEtsqcsCM1C96TeMZywXFmpOxqT5r-PI5LtSs21eYXrdWiCfc5MGyZi3A3WA806Yc%3D&gaats=69b46c63&gaa_sig
Open-Source "GreenBoost" Driver Aims To Augment NVIDIA GPUs vRAM With System RAM & NVMe To Handle Larger LLMs
An open-source, independently developed Linux kernel module called GreenBoost aims to augment the dedicated video memory on NVIDIA discrete GPUs with system memory and NVMe storage
'If it's our time, then that may have to be': Acadia Cafe launches effort to stay in business
The cafe and music venue says "rent and utilities have had to fall by the wayside" amid struggles during Operation Metro Surge.
Google rushes Chrome update fixing two zero-days already under attack
: Skia graphics lib and V8 JavaScript engine brings browser's tally of actively exploited bugs to three in 2026
A Look At Teladoc Health’s (TDOC) Valuation After Analyst Upgrades And Earnings Surprise
Why Teladoc Health is back on investors’ radar Teladoc Health (TDOC) is attracting fresh attention after a run of analyst upgrades tied to its BetterHelp mental health segment, stronger than expected quarterly results, and new plans around artificial intelligence and international expansion. See our latest analysis for Teladoc Health. Despite the recent enthusiasm around upgrades and earnings, Teladoc Health’s 7 day share price return of 6.63% and 30 day gain of 9.84% sit against a much...
The Enduring Unifying Power of Sports
At a time when so much of daily life feels divisive and fragmented, sports remind us how to root together. That may not solve much. But right now, it matters.
How to Solve One of the Most Expensive Problems in Employer Healthcare
A small share of employees drives a disproportionate share of employer health-care spending: They are patients whose complex conditions go undiagnosed as they cycle through a fragmented care system. A diagnostic-focused “center of excellence” model—such as the Mayo Clinic Complex Care Program—offers a different approach: coordinated, multidisciplinary evaluations that identify the right diagnosis quickly. Evidence from employer claims shows that earlier, accurate diagnoses can improve outcomes, reduce unnecessary procedures, and lower costs by shifting care from repeated testing toward targeted treatment.
We're aiming for a 100% growth rate of the AI server business in 2026: Asus co-CEO
S.Y. Hsu, co-CEO of Asus, says it's "highly possible" that enterprise and commercial products will be the highest revenue grossing segment of the company, and that they are aiming to begin mass production of Nvidia Vera Rubin servers in 2026. He also expects the current shortage of memory chips to last until Q4 of 2027.
Critical Microsoft Excel bug weaponizes Copilot Agent for zero-click information disclosure attack
: Could steal sensitive personal and financial data
Priority Unified Commerce Strategy Drives Growth Across All Business Segments
Priority Technology Holdings saw growth across its three segments in the fourth quarter as customers sought the payments and treasury solutions delivered
Exclusive: Amigo AI raises $11M for health care AI
The company is entering a competitive segment and has a Series B planned for later this year.
Exploring Business Segments Across The Walt Disney Company Australia and New Zealand
Apprenticeships at Disney present a unique opportunity to work side-by-side with industry leaders gaining practical, real-world experience while studying towards an apprenticeship qualification.
Spacewalk Preps and Health Checks Using Augmented Reality, Artificial Intelligence
Spacewalk preparations are underway aboard the International Space Station as two astronauts check their spacesuits and review procedures. The Expedition 74 crew also experimented with augmented reality and artificial intelligence to conduct health checks in space. Meanwhile, a U.S. cargo spacecraft nears it departure this week.
For Healthcare, The Real AI Challenge Has Always Been The Data
AI and blockchain are transforming Healthcare by fixing fragmented data, improving public health analytics, and enabling secure, real time medical insights.
Entertainment Media Market Anticipated to Touch USD 6,165.06 Billion by 2035, Driven by Streaming Platforms and Digital Content Consumption | Research by SNS Insider
The Entertainment Media Market is expanding as streaming, gaming, and on-demand digital content reshape consumption patterns, with the U.S. segment growing from USD 971.77 billion in 2025 to USD 1,430.10 billion by 2035.Austin, March 09, 2026 (GLOBE NEWSWIRE) -- The Entertainment Media Market size was valued at USD 3235.49 Billion in 2025 and is expected to reach USD 6165.06 Billion by 2035 and grow at a CAGR of 6.67% from 2026 to 2035. The global market for entertainment media is steadily growi
The U.S. and China running the world together? China says no thanks
For China, President Donald Trump’s use of the term “G2” is an acknowledgment of its growing power. But for U.S. allies, it raises fears they could be cut out of decision-making.
UiPath Expands Into Healthcare AI As Valuation Lags Analyst Targets
UiPath (NYSE:PATH) has launched agentic AI automation tools tailored for healthcare providers and payers. The company is partnering with Genzeon to target data management and revenue cycle workflows. Use cases include medical records summarization, claim denial prevention, and prior authorization processing. For investors following NYSE:PATH, this move takes the company deeper into healthcare, a sector where many workflows still rely on manual processes and fragmented systems. UiPath built...
Maine business owner pleads guilty to tax fraud
The owner of a Maine business that provides interpreter services has pleaded guilty to tax fraud.
Firefox taps Anthropic AI bug hunter, but rancid RAM still flipping bits
: Now if only device makers would deliver higher quality components
US state laws push age checks into the operating system
: Bad legislation, but an especially big headache for FOSS
Q4 Earnings Roundup: Addus HomeCare (NASDAQ:ADUS) And The Rest Of The Senior Health, Home Health & Hospice Segment
Quarterly earnings results are a good time to check in on a company’s progress, especially compared to its peers in the same sector. Today we are looking at Addus HomeCare (NASDAQ:ADUS) and the best and worst performers in the senior health, home health & hospice industry.
Microsoft Copilot to hijack your browser... for your own convenience
: Embeds Edge into AI assistant, ignores questions about opt-in
Red Dragon diplomacy: Students learn from European politics
For a third straight year, Cortland took part in the Global Model European Union.
Ocugen Provides Business Update with Fourth Quarter and Full Year 2025 Financial Results
Conference Call and Webcast Today at 8:30 a.m. ET Enrollment for the OCU400 Phase 3 liMeliGhT clinical trial—the first and largest gene therapy registrational trial for broad retinitis pigmentosa patients—was completed. Topline Phase 3 data expected in the first quarter 2027, advancing OCU400
Apple jacks up MacBook pricing with M5 Pro, Max debut
: No one can hide from the RAMapocalypse, not even Tim Apple
Belgium Gift Card Business and Investment Opportunities Databook 2026: 90+ KPIs on Gift Card Market Size, Retail & Corporate Spend, Competitive Landscape, and Consumer Demographics 2021-2030
The Belgian gift card market offers growth opportunities in digital adoption and evolving delivery mechanisms. Opportunities are found through consumer segmentation, retail sectors, and digital formats. Growth is driven by open and closed-loop options across retail and corporate segments in both online and offline channels. Belgian Gift Card Market Belgian Gift Card Market Dublin, March 03, 2026 (GLOBE NEWSWIRE) -- The "Belgium Gift Card Business and Investment Opportunities Databook - 90+ KPIs
Judging Business Judgment: The Federal Common Law of Bankruptcy Transactions in Chapter 11
By Dolan Bortner (Stanford Law School) When a federal judge encounters a statutory gap too wide to fill through ordinary statutory interpretation, should she borrow state law or make her own rule? The Supreme Court instructs judges to err on the former side, weighing the preservation of otherwise-applicable state law against federal needs that might […]
Scientists just found the brain’s hidden defense against Alzheimer’s
A new study has uncovered why some brain cells are more resistant to Alzheimer’s damage than others. Researchers found a natural cleanup system that helps remove toxic tau protein before it can form harmful clumps. The study also shows that cellular stress can produce a dangerous tau fragment linked to Alzheimer’s. Strengthening the brain’s natural defenses could point the way to new treatments.
Maine businesses push back against against bill strengthening data privacy laws
A bill aimed at strengthening data privacy laws in Maine is getting pushback from several businesses in Maine.
Phish of the day: Microsoft OAuth scams abuse redirects for malware delivery
: Crims hope for payday from malicious payloads rather than stealing access tokens
Motorola partners with GrapheneOS for future phones
: Don't expect to see compatible hardware before 2027