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Results for " Enjoy " 816 found 🔀 AI-powered Shuffle

After-hours business expo in Carteret County

Meet and greet with 65 exhibitors, take part in speed networking sessions, buy into the 50/50 cash drawing, and enjoy hors d’oeuvres, beer, and wine as you work the room.

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Apr 15 • 8:39 AM EDT • Business • witn.com
From a massive living area to an entertainment room and art collection: Ram Kapoor’s approximately Rs 20 crore Mumbai house

Ram Kapoor enjoys a lavish lifestyle in Mumbai with wife Gautami and kids. He once gave a glimpse of his luxurious Mumbai house in a Farah Khan’s vlog. The house is worth around Rs 20 crore and includes an entertainment room, bar and much more. Here’s a look at his lavish Mumbai house:

Fund science, downtown living expensive, protect America

I enjoyed reading the article about how Artemis II “captivated Americans young and old across political divides, bringing unity of wonder, hope and pride to a nation torn by partisan

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Apr 15 • 4:45 AM EDT • Science • postandcourier.com
Liam Rosenior “under severe pressure” says Sky Sports pundit who is worried for coach’s future

Liam Rosenior is “under severe pressure” to beat Man U this weekend, but his team get “beaten up” when they play big teams.If you enjoy Chelsea News coverage and want to see more of it, add us...

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Apr 14 • 11:05 AM EDT • Sports • sports.yahoo.com
How Audrey Hepburn impacted fashion, entertainment and even World War II

“The most important thing is to enjoy your life. To be happy. It’s all that matters,” Hepburn once said. If one is to follow her example, then a life of fashion, elegance, creativity, advocacy and kindness is a life to be enjoyed.

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Apr 14 • 9:58 AM EDT • Entertainment • dailyfreepress.com
Column: As ‘Soccer Dad’ can tell you, today’s youth sports are no simple fun and games

“Soccer Dad” is an enjoyable, enlightening and charming new book about David Murray’s journey into the youth sports world with his daughter Scout.

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Apr 14 • 6:00 AM EDT • Sports • chicagotribune.com
In Leo, Trump Faces a Different Kind of Papal Opponent

Unlike his predecessor, Pope Leo XIV enjoys growing support from a broad swath of conservative Catholics.

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Apr 14 • 5:05 AM EDT • Politics • nytimes.com
Here\'s the performance schedule for Marietta\'s Cherry Blossom Benefit Music Festival

Enjoy musical acts under a stretch of 150 cherry trees in full bloom when Marietta’s Cherry Blossom Benefit Music Festival returns Saturday, April 18.

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Apr 14 • 5:00 AM EDT • Entertainment • lancasteronline.com
Manchester United vs Leeds – Match preview and team news

Manchester United host Leeds United on Monday night to conclude the Premier League action of the matchweek.The Red Devils have enjoyed a remarkable transformation under Michael Carrick since January. ...

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Apr 13 • 1:30 AM EDT • Sports • sports.yahoo.com
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It's music festival season. How to stay safe and healthy while enjoying the show

Music festival season is here, bringing outdoor fun, music and dancing | Talk 1370

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Apr 12 • 1:57 PM EDT • Entertainment • audacy.com
It's music festival season. How to stay safe and healthy while enjoying the show

Music festival season is here, bringing outdoor fun, music and dancing | WWL

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Apr 12 • 1:57 PM EDT • Entertainment • audacy.com
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It's music festival season. How to stay safe and healthy while enjoying the show

Music festival season is here, bringing outdoor fun, music and dancing | KCBS All News 106.9FM and 740AM

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Apr 12 • 1:57 PM EDT • Entertainment • audacy.com
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China, Iran weaponized the global economy to beat the U.S. at its own game

Washington once enjoyed a near monopoly over this type of economic warfare, but now American consumers and companies are starting to feel the pain.

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Apr 12 • 5:00 AM EDT • Business • washingtonpost.com
Seniors: Dennis Ouellette, 80

Ontario Orchards owner not slowing down as he grows his farm market By Stefan Yablonski The seeds for Dennis Ouellette’s career path were sown when he was 6 years old — and he isn’t slowing down. “Since age 6, I grew up an agriculturalist. That is 72 years. Started out with a 37-acre farm when I bought it from my parents and built it up to almost 300 acres. Brought it back down to around 200 acres now,” he said. The location of his business was just a barn, a horse barn, he said. “In 1967, it officially became Ontario Orchards Farm Market. My wife [June] and I graduated [high school] in 1964 and three years later we became Ontario Orchards. We have been here more than 60 years,” he explained. “It is the same location. We have expanded over the years as the customers mentioned different things; we have expanded to bring in different products. “What keeps me going is I totally enjoy what I am doing. I enjoy the people that I work with. The customers are wonderful. Mostly, more important than anything, is my family — my wife, my daughters, grandchildren, son-in-law — we are still very much a family business I’m not going to retire just yet.” He also enjoys the changing seasons. “Ontario Orchards is a four-season business. There is always something new; more energy, more interest. Not only for the business but for my staff, the people that work here. Things keep changing, changing. We are always looking forward to something new and exciting,” he said. They work with quite a number of local farmers within the area and throughout the state, throughout the country and from around the world.” “We do have things from different countries around the world. But specifically, we are very excited about the local. We have an over 200-acre farm. We sell just about everything we raise on that farm right here at the farm market. For example, we press cider year-round. We make baked goods every day, year-round. We sell our apples 12 months a year.” “Today, there are so many products in Ontario Orchards that we never would have thought of in 1967,” he continued. “I attribute a lot of that to my daughters. I like the young blood and new energy. That is very crucial to a business, it keeps it vibrant.” What’s his favorite part of the job? “I don’t have a favorite part. I enjoy it all. I have a lot of intertest in other things,” he said. “I have staff that knows so much. I can go to the staff and say, ‘I don’t know what this is, you tell me what this is.’ They are so knowledgeable. It is impossible for one person to know everything in this place. In the summer, staff is about 60; in the winter about 20, 25.” He added that he plans on being around for several more years.

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Apr 11 • 4:39 PM EDT • Business • oswegocountybusiness.com
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Seniors: John Lemp, 70

Has been working for more than 50 years in the business — M. Lemp Jewelers in Syracuse — that his great-grandfather started in 1890 By Mary Beth Roach Don Lemp owns and represents the fourth-generation of the family business, M. Lemp Jewelers, but he still calls himself “a counter guy.” “I love interacting with couples. It’s a wonderful business. You’re celebrating marriages, engagements, births, anniversaries — all these different significant moments that people invite you into their lives for whatever brief period of time it might be to help them celebrate whatever their important occasion is,” he said. This is one of several reasons why Lemp, at 70, has been working for more than 50 years in the business that his great-grandfather started in 1890. Always located in the downtown Syracuse area, the store has been situated in the building that the family owns on East Fayette and Warren streets since 1971. He jokes that he’s been in the business so long he is now selling engagement rings to the second generation in some families. He also loves the opportunity to learn about the ever-changing industry and gemstones. “You have to know not only diamonds, but all the colored stones, from A to Z, from andalusite to zircons,” he said. Lemp said he had originally thought he wanted to become an attorney, but while working part-time in the store while attending college at Syracuse University, he decided to follow in the family business. His father, Walter D. Lemp Sr., and his mother tried to discourage their son from pursuing retail, reminding him of the hectic hours and lifestyle intrinsic in this business. But the younger Lemp [whose full name is Walter D. Lemp Jr.] prevailed. So, over the years, father and son got to work together in the family business for 35 years. And while many other jewelers retreated from downtown to suburban malls in the 1970s, the Lemps decided to stay downtown. And it’s a decision that Lemp Jr. feels it has worked out well. As he explained, downtown Syracuse is seeing a rebirth. One website, Point2Home.com, has noted that more than 6,000 people live there and the median income is about $62,000. In addition, according to the website that Lemp built years ago, the store can cater to customers throughout the country. His customers, whether from across the country or across Onondaga County, are just one reason that Lemp stays engaged in the business. His employees, the opportunity to continue to learn in an industry, and the challenge to continue to improve business are all other reasons, he noted. He’s also been able to travel to India to buy diamonds and he enjoys buying and selling estates. “I’d rather gallop in the corral than ride into the sunset,” Lemp said.

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Apr 11 • 4:39 PM EDT • Business • oswegocountybusiness.com
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Seniors: Carol Watson, 72

Owner of Carol Watson Greenhouse and Landscaping in LaFayette enjoys her growing business — still puts in six-, seven-day weeks By Mary Beth Roach Carol Watson, the owner of Carol Watson Greenhouse and Landscaping, has been in gardens since she could walk. Literally. She said she learned to walk in her grandfather’s garden, which was next door to her current home and business in LaFayette. Today, at 72, she is running the business that her mother, Claire, opened in 1981 as Watson Greenhouse. Watson worked part-time for her mom until 1990, when she joined her full time. While she may not have had any formal horticultural experience, she said she learned so much about growing and raising plants from her mom, who had an abundance of energy and talent. Now, after 35 years in the business full time, Watson has no plans to retire, although she joked that she’d like a couple of days off a week. On her seven-acre site, complete with four greenhouses, Watson said her favorite parts of the job are working with and educating her customers; helping some of her young customers build terrariums; conducting occasional class field trips; and supporting local art by decorating the shop with an eclectic mix of pottery from at least four area craftspeople. A one-time employee of the former Dey Bros. department store in Syracuse, Watson said she loves merchandising and enjoys displaying unique pieces of art on shelves and even suspending from ceilings. “We’re creative. We also had top quality plants. We got a reputation of quality plants and unusual products,” she said. It’s tending to her customers and her plants, showcasing the unusual products, and hosting special events to benefit the community that keep her motivated to work six to seven days a week. “I just love it. I love taking care of the plants. I’m one of the few people that really enjoys watering,” she said. And while she has cultivated a solid customer base over the years, she remains savvy in her marketing efforts to draw in new customers. For example, she does a gardening segment on CNY Central television; her active Facebook page has thousands of followers; and she hosts a number of unique events and classes that not only introduce her shop to potential new clients, but some benefit nonprofits as well. About 13 years ago, when the local symphony orchestra was struggling, she said she wanted to help. So, partnering with the group, she began offering concerts, called Soirees, featuring the Syracuse Orchestra’s string quartet. Following up on a suggestion from a customer whose brother is a deejay in retirement, specializing in sock hops, she hosted the greenhouse’s first sock hop. Plants got moved back toward the walls to make room for dancing; a caterer was brought in, offering diner-like food; guests came in period outfits; and proceeds went to the Food Bank of CNY. She is excited about doing it again in October. Via her website, she promotes the greenhouse as an “oasis in the snow,” offering visitors the opportunity to pick up some decorating and gift ideas while taking in the floral and citrus scents. And she also caters to her four-legged friends. Over this past winter, she said, she came up with a “brilliant idea,” although at the time she didn’t appreciate just how brilliant it would become. Feeling it too cold outside to take her dog for a walk, she opted to bring it into the greenhouse. And before long, she was inviting people to bring their dogs into the big greenhouse as well. She looks forward to extending that invitation again this upcoming winter season. For Watson and her customers, the greenhouse is always in season.

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Apr 11 • 4:39 PM EDT • Business • oswegocountybusiness.com
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Amazon Luna Removing Paid Games And Offering No Refunds

You have until June 10 to enjoy the games you purchased on the cloud streaming service

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Apr 10 • 11:06 AM EDT • Technology • kotaku.com
Sue Serino Invites Seniors to Learn Laughter’s Health Benefits

Dutchess County Executive Sue Serino and the County’s Office for the Aging (OFA) invite older adults to enjoy an uplifting and engaging afternoon focused on the health benefits of humor at “Spring Into Happiness: Laughter Edition."

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Apr 10 • 8:00 AM EDT • Health • dutchessny.gov
Netflix's 'Thrash' is junk-food entertaining to roast, mock and enjoy

From the director of “Violent Night” (Tommy Wirkola), “Thrash” is Netflix’s first summery film of the year. In 2026, you can’t simply have a natural disaster movie or a predator

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Apr 10 • 1:00 AM EDT • Entertainment • galvnews.com
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North Dakotans can learn about resources to grow healthy habits on April 18 at Gateway to Health event | Health and Human Services North Dakota

Individuals and families are invited to the fourth annual Gateway to Health community event, which includes activities for all ages on Saturday, April 18, 10 a.m.- 4 p.m. at North Dakota’s Gateway to Science in Bismarck. Participants will enjoy free access to the science center during their registered two-hour time slot, along with access to interactive booths and exhibits promoting health and wellbeing through hands-on activities, games and prizes.

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Apr 9 • 8:15 PM EDT • Health • hhs.nd.gov
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HOMETOWN ENTERTAINMENT: Weekend entertainment guide: Comedy, music and spring festivals

Enjoy a variety of events this weekend, including stand-up comedy, dance parties and a spring festival

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Apr 9 • 5:30 PM EDT • Entertainment • wdbj7.com
Another Big Night for Democrats: Tuesday’s Wisconsin and Georgia Results

Democrats enjoyed another double-digit victory in a Wisconsin state Supreme Court race; their win will expand the liberal majority on the body to 5-2. Meanwhile, Republicans held GA-14, although it made for another Democratic overperformance.

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Apr 8 • 2:16 PM EDT • Politics • centerforpolitics.org
13th annual Tuck Entertainment Easter Egg Hunt brings joy - WNKY News 40 Television

FRANKLIN, Ky. – Hundreds of children and families gathered in Franklin, Kentucky for the 13th annual Easter Egg Hunt by Tuck Entertainment at Lincoln Park. Kids flooded the park and enjoyed the free family event. There were prize giveaways, free haircuts and so much more. However, the main goal was to share the reason for the season, and that’s their...

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Apr 6 • 7:14 PM EDT • Entertainment • wnky.com
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Kids will spring into science with April’s Parents’ Night Out at DHDC

From 5:30 to 9:30 p.m. on Friday, April 10, the Don Harrington Discovery Center is offering a chance for children ages 4-11 years old to crack into hands-on experiments while caregivers enjoy an evening to themselves.

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Apr 6 • 3:06 PM EDT • Science • newschannel10.com
The Chamber Corner: From startup to legacy: Strengthening family businesses in Worcester

One of the most enjoyable aspects of my role as president and CEO of the Worcester Regional Chamber of Commerce is to witness how our chamber team assists individuals in launching their businesses.

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Apr 6 • 6:00 AM EDT • Business • wbjournal.com
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Double Dragon Creator Yoshihisa Kishimoto Has Passed Away

"I hope you will continue to enjoy my father's works"

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Apr 6 • 4:00 AM EDT • Technology • timeextension.com
Why the controversy with mail-in ballots?

Most Coloradans enjoy the right to vote “by mail” at election time. Most Americans favor this process. But U.S. President Donald Trump is trying to federalize (nationalize) this practice and shift the supervision of voting from county clerks to the Department of Homeland Security and the U.S. Postal Service. He issued an executive order to […]

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Apr 6 • 2:15 AM EDT • Politics • coloradopolitics.com
Head to Key City in April to enjoy live rooftop music

VICKSBURG, Miss. (VDN) — April is bringing the vibes to the rooftop! Join the group at Key City Rooftop for a month of great music featuring talented local and regional artists. Whether you want to sit back and enjoy the sounds or jump in and be part of the action, Key City has you covered—bring your […]

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Apr 5 • 3:30 PM EDT • Entertainment • vicksburgnews.com
“I couldn’t enjoy it fully until now”: Crimson Desert’s once‑exclusive PS5 mode finally arrives on Xbox — and I’m ready to dive back in

Crimson Desert’s 4K update arrived on PlayStation 5 first, leaving Xbox Series X users waiting, with Pearl Abyss declining to explain the temporary lack of parity.

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Apr 5 • 9:36 AM EDT • Technology • windowscentral.com
Portland warns outdoor dining setups could pose health risks without proper maintenance

If you are planning to enjoy the warm weather by dining outside, you might want to check before you take your seat.

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Apr 4 • 9:55 PM EDT • Health • katu.com
A retired grandpa thought he was in good health — until he fainted during a bike ride

John Cantrell was enjoying his retirement until an unexpected condition forced him to choose between two kinds of heart surgery.

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Apr 4 • 8:00 AM EDT • Health • cbsnews.com
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‘This is a recalibration’: Trump Cabinet worries no one is safe after Bondi and Noem firings

When President Donald Trump ousted his attorney general, Pam Bondi, it sent a clear message to his remaining Cabinet members: The job security they’ve enjoyed until now is no longer guaranteed.

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Apr 3 • 6:15 PM EDT • Politics • cnn.com
Kids, Competition & Pressure: Keeping Sports Fun

How can parents help their children enjoy the game without feeling overwhelmed?

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Apr 3 • 5:02 PM EDT • Sports • wnem.com
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Do your kids play sports? Here’s how to keep it fun and stress free

The American Academy of Pediatrics reports 40% to 50% of youth athletes feel stressed by sports-related expectations. So how can parents help their children enjoy the game without feeling overwhelmed?

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Apr 3 • 11:59 AM EDT • Sports • news4jax.com
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Celebrate Science Day Takes Off at New Location: Reading Regional Airport

From helicopters to birds and the principles that lift them skyward, guests of all ages will discover how things fly while also enjoying a wide range of interactive STEM activities beyond aviation.

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Apr 3 • 4:45 AM EDT • Science • bctv.org
GTA+ Members Can Claim a Free Bravado Buffalo STX Pursuit Law Enforcement Vehicle

Get behind the wheel of the aggressive Bravado Buffalo STX Pursuit Law Enforcement Vehicle now available to GTA+ Members one week before everyone else on April 9. Enjoy other great benefits including bonuses for Dispatch Work and Bail Office Bounties,...

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Apr 2 • 3:15 PM EDT • Technology • rockstargames.com
LA Chargers help high school athletes learn lifesaving CPR

More than 250 high school student-athletes from across the Los Angeles Unified School District spent a day learning about heart health alongside Los Angeles Chargers players.Students learned hands-only CPR, met Chargers players Elijah Molden and RJ Mickens in UCLA Health Sports Performance Training, Powered by Exos, and enjoyed lunch on the patio at Huddle for Heart Health, held March 19 at The Bolt, the Chargers’ official practice facility in El Segundo. RJ Mickens, left, and Elijah Molden joined more than 250 LAUSD high school students at the Huddle for Heart Health event. (Photo courtesy of Joaquin Torre/Los Angeles Chargers) Along with learning CPR techniques, students practiced performance training on the LA Chargers practice field in El Segundo. (Photo courtesy of Joaquin Torre/Los Angeles Chargers) LA Chargers defensive back RJ Mickens visits with high school students at the Huddle for Heart Health event. (Photo courtesy of Joaquin Torre/Los Angeles Chargers) The event was presented by UCLA Health, the American Heart Association, the Los Angeles Chargers and LAUSD.Hands-only CPR is a lifesaving skill, said David Sato, MD, board president of the American Heart Association Los Angeles.“We save more lives when we work together,” said Dr. Sato. “This collaboration with UCLA Health and the Los Angeles Chargers to teach students how to perform hands-only CPR helps ensure more families in Los Angeles have someone ready to act in a cardiac emergency when seconds count.”Hands-only CPR is a lifesaving procedure for cardiac emergencies that doesn’t involve rescue breaths. It involves pressing hard and fast in the center of the chest of a teen or adult who has collapsed. Pressing can be done to the beat of the Bee Gee’s hit “Stayin' Alive, which, at 100 beats per minute, is the minimum rate at which to push during hands-only CPR, according to the American Heart Association. LA Chargers defensive back Elijah Molden, standing, helps high school students learn CPR skills. (Photo courtesy of Joaquin Torre/Los Angeles Chargers) Most cardiac arrests that don’t happen in the hospital happen at home, and hands-only CPR is as effective as CPR with breaths in the first minutes following a cardiac emergency.

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Apr 2 • 8:00 AM EDT • Health • uclahealth.org
UCLA women enjoy 'home-court advantage' during Final Four run
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Apr 1 • 6:08 AM EDT • Sports • sports.yahoo.com
Predicting spring bloom is an art

Do you ever wish you could predict the future? The National Park Service in Washington D.C. does it every year when they forecast when the Capitol’s cherry blossoms will reach peak bloom. People travel from all over the world to enjoy the annual National Cherry Blossom Festival and to glimpse these fragile flowers before they are gone. On this month’s Nature Quest, we learn the ins and outs of cherry tree blossoms, how scientists make that big prediction every year — and why all this focus on blooms can help scientists better understand climate change. This episode is part of Nature Quest, our monthly segment from listeners noticing a change in the world around them. To participate, send a voice memo to shortwave@npr.org with your name, location and your question about a change you're seeing in nature!Want to learn more about nature’s calendar? Check out our first Nature Quest episode on whether flowers are blooming early.Listen to every episode of Short Wave sponsor-free and support our work at NPR by signing up for Short Wave+ at plus.npr.org/shortwave.

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Mar 31 • 3:00 AM EDT • Science • npr.org
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Sunday Science: The return of the ruby-throated hummingbird

As spring starts to sprout in Southern New England, birdwatcher's have plenty to look forward too. Turning the calendar to April means that the ruby-throated hu

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Mar 29 • 10:24 AM EDT • Science • turnto10.com
Runners enjoy the Visit Tuscaloosa Half Marathon and DCH Health System 5K

Check out the photos of runners in the DCH Health System 5K and the Visit Tuscaloosa Half Marathon.

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Mar 28 • 11:21 AM EDT • Health • tuscaloosanews.com
Gambling is entertainment — taxpayers shouldn’t foot the bill for losses.

The tax code should make clear that activities fused with fun, excitement and personal enjoyment are never an occasion for a tax deduction.

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Mar 28 • 8:00 AM EDT • Entertainment • thehill.com
Everything You Missed at Shop TODAY Stages 2026 Health & Wellness Summit

Guests enjoyed a day full of expert chats, pampering and, of course, plenty of free products.

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Mar 27 • 2:07 PM EDT • Health • today.com
New Congressional bill targets sports team relocations

More than 40 years after the Colts left Baltimore for Indianapolis like thieves in the night, those in a profession that enjoys nearly the same level of respect are trying to prevent it from happening again.

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Mar 26 • 3:54 PM EDT • Sports • nbcsports.com
PWHL Takeover Tour in Detroit as women's hockey rides Olympic high

Women's hockey is enjoying a wave of interest thanks to USA's victory at the 2026 Olympics, a boost for the PWHL.

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Mar 26 • 5:13 AM EDT • Sports • freep.com
Weekly Entertainment Report for Southern NH, March 26-29: Live music and lively arts

Live music and the lively arts connects us to the human experience. Go forth and enjoy what is waiting for you.

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Mar 25 • 10:56 PM EDT • Entertainment • manchester.inklink.news
Broad Ripple welcomes new sports, entertainment venue

BROAD RIPPLE, Ind. — The Broad Ripple neighborhood will soon be home to another place where people can enjoy fun and food. Stick & Hack Entertainment is opening its second location at 46th Stre…

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Mar 25 • 6:58 PM EDT • Entertainment • fox59.com
Hands-on science program brings STEM to life at Mass. school

The school's 5th graders enjoyed a special science lesson by Preeti Mostello, an educator with the nonprofit Traveling Science Workshops from the Discovery Museum in Acton.

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Mar 25 • 5:26 PM EDT • Science • wcvb.com
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New Pat Summitt documentary is a very enjoyable watch, but incomplete

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Mar 25 • 4:04 PM EDT • Sports • usatoday.com
Play It Again Sports (Arkansas Sports University Inc.) - Talk Business & Politics

Cameron Campbell always enjoyed playing sports. His two favorite sports were basketball and baseball. When he got out of school, he wanted to do something where he was still involved...

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Mar 25 • 9:30 AM EDT • Sports • talkbusiness.net
MY HERO ULTRA RUMBLE : Patch Notes 1.15.0

Through our maintenance update on March 25, 2026, we made the following changes. New features, System Adjustments, Adjustments to Area Control Battle, Battle Style Adjustments, Bug fixes... We hope you continue enjoying MY HERO ULTRA RUMBLE.

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Mar 25 • 5:37 AM EDT • Technology • en.bandainamcoent.eu
‘The Price Is Right’ Nurse Speaks Out After Winning a Car

'My goal was just to enjoy the day and come what may.'

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Mar 24 • 4:51 PM EDT • Entertainment • yakimaherald.com
UMaine sports management students enjoy networking trip to Indiana

Westfield’s Droplight Grand Park Sports Campus, more Indianapolis-based experiences

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Mar 24 • 2:55 PM EDT • Sports • wabi.tv
Marathon has sold 1.2M copies across Steam, PS5, and Xbox

Alinea Analytics estimates show that Marathon has generated gross revenues of $55M via 1.2M copies sold on Steam, PS5, and Xbox: Looking at the split between Steam, PS5, and Xbox, Steam is clearly the main platform for Marathon, accounting for a little under 70% of the audience (800K copies sold). Meanwhile, PS5 takes about 19% (217K) and Xbox (including console, PC, and cloud) accounts for a bit over 11% or 133K. Marathon is technically a first-party Sony title, so seeing the home console struggle to break 20% of the volume is a notable data point for the ongoing platform-agnostic debate. PlayStation Studios online games will almost certainly continue being multiplatform (despite Sony reportedly pulling back on PC releases). Subscribe for free to get the most accurate games estimates in your inbox twice a week 🫶 Subscribe As for Marathon, the consensus among hardcore players who pushed through the awkward onboarding phase – myself included – is that it’s fantastic. The gunplay, aesthetic, and presentation are among the best in the shooter genre. A great game doesn’t always equal an immediate hit, though, as shown by our estimates. Things are looking lukewarm right now. But this might be one of those marathon-not-a-sprint situations. Had to, didn’t I? Why wasn’t Marathon a hit on the same level as Arc Raiders? One topic that came up in a lot of conversations at GDC this year was why Marathon hasn’t hit the same stratosphere as Arc Raiders. On paper, they’re both extraction shooters, and Marathon has the Bungie pedigree – the house that built the gold standard for gunplay in Halo and Destiny. Marathon’s neon-futuristic aesthetic also distinguishes itself from the gritty realism of Tarkov or the post-apocalyptic hope of ARC Raiders. But vibes can only get you so far for first impressions if the onboarding feels like a brick wall. Marathon is a sweaty PvP-focused experience with a first-time user experience and UI that I can only describe as dreadful. Players are dropped into a complex ecosystem where the UI, though visually striking, is functionally uninformative, forcing users to manually hover over nondescript, identical icons just to identify basic gear or weapon mods. This lack of clarity is compounded by punishing mechanics like a severe heat gauge for movement and a scarcity of vital resources, all without a clear tutorial or a low-stakes mode to learn the ropes. Most people – even top streamers and veteran shooter players – have no idea what’s going on in Marathon at first. Arc is on the complete other end of the spectrum. As we covered here and here, Arc Raiders offers a more collaborative, approachable loop where players often work together toward shared goals. And the objectives are instantly clear. To many players, this contrast only emphasised Marathon’s issues, especially during the testing period. Players understand the Arc Raiders loop within 30 minutes, while Marathon acts as a massive filter, chewing up newcomers and spitting them out before they can experience the depth of Bungie’s signature gunplay. What I’m getting at here is that the poor first-time user experience of Marathon’s Server Slam likely stifled launch sales, while the opposite was true for Arc. Let’s look at the pre-launch copies sold for each game during their respective Server Slams (launch-aligned) : Looking at the trajectory: Arc Raiders saw a massive 80% jump in copies sold during its three-day Server Slam (day -13 to -11). Players jumped in, realised the water was fine, and immediately opened their wallets. Marathon, meanwhile, saw a 49% increase in the four days following its Slam (Day -7 to -3). At the time of each game’s respective launch, Arc Raiders had nearly double the Steam footprint of Marathon – and word of mouth only continued to grow. Bungie could have had more time to fix the onboarding process had the beta happened earlier. But Marathon launched three days after the beta finished. These factors limited the launch sales quite a bit, I reckon. Marathon has found a niche audience, though Despite the friction-heavy start, the data suggests that those who survived Marathon’s onboarding are loving life. We’ve been tracking cross-platform DAUs, and while there’s the expected post-launch leakage, many players are sticking with it. After peaking at 478K total DAUs on its first Saturday, Marathon has settled into a respectable rhythm, holding 345K DAUs as of yesterday and averaging 380K DAUs across the weekend. Steam continues to do the heavy lifting here, consistently accounting for the lion’s share of the daily players. Players have been putting in the hours, too: On Steam, Marathon’s average playtime has climbed to 27.8 hours, significantly outpacing the console averages on PS5 (16.5h) and Xbox (17.3h). Even more telling than the averages: 22% of the Steam audience has surged past the 50-hour mark, and nearly 7% have already logged over 100 hours. Subscribe for free to get the most accurate games estimates in your inbox twice a week 🫶 Subscribe This data suggests that once the Bungie magic clicks, it hooks players deeper than the average extraction shooter. There’s also started to be a shift in the game’s discourse. Marathon launched as one of those games that’s cool to hate. But as Marathon’s 100-hour club grows, we’re seeing conversations around its mechanical merit outweigh the negativity. Several high-profile creators, who were initially vocal critics, have spent the last week coming around on the mechanical depth of the endgame. It’s a subtle but positive signal; the hate train is losing steam, and a new narrative about the game is emerging. Bungie faithfuls unite Another interesting metric in Marathon’s first few weeks is who, exactly, is playing. Bungie leans heavily on its prestige as the “makers of Halo and Destiny,” in its marketing, and that message has clearly hit the mark. On Steam, the gravity (hammer) of Bungie’s previous work is unavoidable. A staggering 78.2% of Marathon players also played Destiny 2. The trend carries across other platforms, with 74.2% of PS5 players and 82.7% of Xbox players also having played Destiny 2. The Halo legacy lives on, it seems. More on that in a bit. While Destiny 2 went free to play, these numbers still represent a high-intent migration of a fanbase that trusts Bungie’s specific brand of kinetic gunplay and cryptic world-building. The Xbox data adds another layer of legacy. About 85.7% of Marathon players on Xbox have played Halo Infinite, while over half of the Steam audience has spent time in Halo Infinite and 36.1% in the Master Chief Collection (a paid collection of the old Bungie-made legacy games). Interestingly, we see a 55.9% overlap with ARC Raiders on Steam. Overlap is even higher there on PlayStation (60.5%) and Xbox (66.5%). And there’s also significant crossover with Helldivers 2 on all platforms, too. Subscribe for free to get the most accurate games estimates in your inbox twice a week 🫶 Subscribe Bungie has found some of its fans with Marathon, and the challenge now is keeping this engaged in a high-stakes PvP environment when they’ve spent the last decade primarily enjoying the power fantasies of PvE. On that note… Go the full 26 miles? Or cut and run? Time for some could’ve, should’ve, would’ve. These things would have improved Marathon’s performance at launch: A more robust onboarding process, perhaps in the form of a short single-player/PvE campaign. We know Bungie fans love this stuff. A traditional arena-based mode akin to Destiny’s Crucible could have been a bridge for the cautious players who’d have been otherwise deterred by the Server Slam. It’s also a great palate cleanser after getting merked. Introducing a dedicated PvE environment would have similarly diversified the conversation and lowered the barrier for the Bungie faithful who found the pure PvP extraction loop too abrasive. PvE is safer than PvP these days. There’s an argument that a thin PvE mode would have just felt like a budget Destiny, potentially hurting the brand more. But given how dire the FTUE is, I think it would have been a net positive. Any kind of tutorialised loop that demystifies the stakes, really. While there is merit in a studio sticking firmly to a singular creative vision, and going all in on the hardcore extraction loop. Less forgiving is the technical reality is that the user interface and first-time user experience (FTUE) were not at a commercial standard for launch. Subscribe for free to get the most accurate games estimates in your inbox twice a week 🫶 Subscribe In a landscape where player time is oversaturated and the most contested currency, a flawed FTUE is a critical failure point. But it’s not all doom and gloom, as Marathon has an incredible, unique gameplay loop, suggesting that financial success is still attainable if Bungie can pivot effectively. Bungie and PlayStation now face a difficult strategic crossroads, though – one within a challenging games market. They could: Double down on Marathon with a long-term Rainbow Six Siege- or No Man’s Sky-style recovery plan, which is something I heard Last Stand Media’s Chris Maldonado mention last week. While this could be a sunk-cost fallacy in action, it could eventually yield the audience the game’s mechanical depth deserves. Shift focus toward the inevitable Destiny 3 or another project, mitigating the escalating opportunity cost and cutting their losses, so to speak. Doing both is an expensive proposition, given the high overhead and burn rate of operating out of Bellevue, Washington. With Sony recently demonstrating a lower threshold for underperforming studios and projects, the margin for error has vanished. Whatever happens, the next six months will determine whether Marathon becomes a cornerstone of Sony’s live-service portfolio or a cautionary tale of vision exceeding accessibility. I’m hoping it’s the former, because Marathon rocks. As always, hit subscribe to get updates on Marathon and other relevant games. Subscribe Want to get your hands on our data for yourself – for free? We’re offering a free trial of our platform for games companies. Send us a message here, or reply to this email, and we’ll set you up. The last word Reply to this email – or reach out here – if you have any feedback for the newsletter – or want to request a game for us to cover. [Alinea Analytics boasts the most accurate PC and console estimates in the business. Game makers use our platform to understand their audience, keep an eye on the competition, monitor sales trends, and spot new opportunities. We equip game studios and financial institutions with accurate data and the confidence to make smarter, data-driven decisions. Want to talk about all things games market data? We’d love to chat!]

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Mar 24 • 2:06 PM EDT • Technology • alineaanalytics.substack.com
Live Entertainment on Local Stages this Spring

Warmer weather, blooming flowers, and extra daylight aren’t the only seasonal delights to enjoy this spring. There’s also a whole new crop of live entertainment! Here’s what you can see on s…

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Mar 24 • 12:59 PM EDT • Entertainment • kidfriendlydc.com
From elections to redistricting, Jenna Persons-Mulicka’s footprint grows in the House

For now, though, she’s enjoying a break from action back home with her sons.

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Mar 24 • 10:05 AM EDT • Politics • floridapolitics.com
We disagreed on politics. We agreed on wine. That was enough.

At the Virginia Governor’s Cup Gala in Richmond earlier this month, a very dapper gentleman approached me and introduced himself. In his light-colored suit and bowtie, he looked very Southern in a classical sense, the sort of Virginia Gentleman you used to see south of the Rappahannock as recently as my college days. “I’m a longtime reader and fan of your writing, if not your politics,” he said. His comment was the proverbial iron fist in a velvet glove, simultaneously conveying praise and disapproval while establishing boundaries. Man, I wish we still discoursed like this instead of shouting bromides and insults to try and “own” our opponents with a funny meme and a furrowed brow. Subscribe “Well, we’ll always have wine to share together,” I said, and thanked him for his kind words. We clinked glasses, exchanged pleasantries about the delicious gold medal-winning wines being poured that evening, and went our separate ways. Our exchange reminded me that more unites us than divides us. Wine brings people together to share a meal and a few hours of joy despite our differences.1 That’s why I refer to the wine community — including readers and consumers — rather than the wine industry. Together, we are so much more than production, distribution and sales statistics. A few minutes later the evening’s awards ceremony began. Applause grew as the 12 winemakers who made the top-scoring wines for the Governor’s Case took the stage, including a loud cheer for Jonathan Wheeler of Trump Winery and his 2018 Blanc de Noir sparkling wine. All the winemakers on stage had reason to be proud, Wheeler perhaps more so. Trump Winery was the only winery to win six gold medals in the competition this year. (Wineries are limited to six entries.) Two of Wheeler’s ciders also won gold medals in a separate competition. When you cover the labels and take the sour taste of politics off your palate, the wines are pretty darn good.2 Then Gov. Abigail Spanberger, newly elected Democrat and Virginia’s first female governor, was introduced to great applause to announce which of the 12 wines had won the Governor’s Cup. She spoke for a few minutes about the importance of wine to Virginia’s economy and tourism and the international acclaim Virginia wine has received. Just two weeks earlier, she gave the Democrats’ response to Trump’s State of the Union speech, but this night wasn’t about politics. That didn’t stop several people in the crowd from speculating on the irony should she have to present the trophy to Trump Winery. In the end, Valley Road Vineyards was displayed on the screen behind Spanberger as the winning winery. Blue Bee Cidery in Richmond took top honors for that category. The crowd cheered a female governor presenting the state’s highest trophy to a female winemaker and then resumed the evening’s festivities, united by their mutual love of wine. A whiff of politics couldn’t dim the cheer of celebration and a community united by its love of wine. In Memoriam: Michel Rolland The global wine community lost a giant March 20, with the passing of Michel Rolland. He was 78. Rolland was the original “flying winemaker,” a globe-trotting consultant who helped Bordeaux regain its mojo in the 1970s and then shaped the rise of Napa Valley cult Cabernet as consultant to Simi, Harlan, Newton, Screaming Eagle, Araujo, Dalle Valle and other wineries. He was instrumental in Argentina’s rise to prominence and even had his own winery, Clos de los Siete, in a partnership with other wine families. Rolland’s career arc paralleled that of Robert Parker, the world’s most influential critic. Parker championed many of the wines Rolland consulted on, helping build his reputation and demand for his services. It also made him a target for Parker’s critics. As W. Blake Gray wrote on Wine-Searcher in his excellent tribute to Rolland: Rolland created the type of wines Parker loved: rich body, plenty of fruit, soft tannins. He sometimes faced the accusation of creating a generic international style of red wine, where the great wines he made in Argentina were indistinguishable from the great wines he made in France. Rolland chafed at that critique, as did many of his fans. He was credited with championing green harvesting and leaf pulling, as well as careful selection of grapes in the winery, practices we nearly universally think of today for high-quality winemaking. “Michel was an incredible innovator who changed how wine was made and how grapes were grown,” Napa Valley winemaker Aaron Pott wrote on Facebook. “His work has transformed the wine trade. He created new ways of looking at wine, tasting wine, evaluating ripeness and quality. … This was not just a man with a ‘style’ that he imposed on vineyards but a man that understood how to make great wine from great sites.” Rolland started his consulting company in 1973 in Libourne, in Bordeaux, with his wife, Dany. Both had graduated the year before from Bordeaux’s Institute d’Oenologie. The couple sold their majority share in the business in 2020, according to Wine Spectator. Over his career, Rolland reportedly worked with more than 100 wineries in 20 countries. He even made it to Virginia, where he consulted for Kluge Estate in the mid-2000s. (Kluge Estate is now Trump Winery.) Reader feedback, please! Last week, I did my first WineLine Live! with Dr. Laura Catena of Catena Zapata winery in Argentina. We enjoyed a fascinating discussion about her efforts to preserve the genetic heritage of old vineyards in Mendoza. I conceived of WineLine Live! for paid subscribers, as a thank you for your financial support. And while only a few people joined live, the video now has more views than I have paid subscribers, so I guess that’s pretty good. Even so, I’m considering opening future installments to anyone on Substack to reach a broader audience. So my questions to you: Should these be public? And what format do you prefer? Live gives a chat feature with the potential for viewers to interact with me and the guest, while a video post would just be that. Another alternative is a podcast, which would just be audio, without video of my chins. Please let me know in the comments. Leave a comment In the Glass A few wines I’ve enjoyed recently: Bonny Doon Vineyard Take Me to Your Liter, Le Cigare Volant, Red Wine of the Earth. 2023, Central Coast, CA. Blend of Grenache, Syrah Cinsaut and Petite Sirah. Delightful wine with expressive red fruit flavors, casual drinking. Doon lovers of a certain age will remember Randall Grahm’s Big House Red; this is more in that style than his original Le Cigare Volant, modeled after Chateauneuf du Pape. The liter bottle makes it an even better value. I see this online at about $15. Great value. Albert Bichot Bourgogne Pinot Noir Origines 2023. 13% - Textbook pinot noir and an excellent, affordable entry (regional) Burgundy. Wine Enthusiast Top 100 Wines of 2025. $24 at Total Wine & More. Loma Larga Pinot Noir 2021 “Coastal Cool Climate Wine”, Valle de Casablanca, Chile. An older sample, showing beautifully. Spicy and fruit forward. I’m seeing widely varied pricing online, from $18-$32. At the lower end, it’s a terrific value. 13.5% Dr. Loosen Riesling Dry 2016, Mosel, Germany. Found this “in the stack.” And it stacked up well, shedding some of its youthful acidity for opulent Riesling character, including a hint of the mineral oil older Riesling often features. A great value, as I’m seeing it as low as $14 online. 12% abv. Red Tail Ridge Blau Franc Blend 2024, Sans Oak, Finger Lakes. 13.4% abv. The name is a neat portmanteau of Blaufrankisch and Cabernet Franc, thus Blau Franc. The blend is 50-50, no oak involved. The Blau dominates on the palate, with the spicy caraway seed (think New York deli rye bread). The Franc adds body. The result is juicy, energetic and joyful. Sokol Blosser Estate Rosé of Pinot Noir 2025, Dundee Hills, Willamette Valley, Oregon. This first rosé of 2025 was a welcome respite to our cold, snowy winter here in the Mid-Atlantic. Oh man, I needed this! Bright and energetic, exuberant even, it perks up the mood and goes down fast. 13%. Certified B Corp. Ingredient and nutrition labeling, and in a modest way that doesn’t occupy a lot of label space. (Since it’s not required, presumably there are no minimum font size requirements.) More wineries should follow this example. Dave McIntyre's WineLine is a reader-supported publication. To receive new posts and support my work, consider becoming a free or paid subscriber. Subscribe Thanks for reading Dave McIntyre's WineLine! This post is public so feel free to share it. Share 1 Some restraint may be required. 2 Especially the bubblies.

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Mar 23 • 10:54 PM EDT • Politics • dmwineline.substack.com
Deep dive
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UCLA tries to enjoy rare opportunity for Lauren and Sienna Betts

UCLA works to celebrate Lauren and Sienna Betts as successful sisters and individual playmakers pushing to help the Bruins win.

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Mar 23 • 6:30 AM EDT • Sports • latimes.com
Microsoft Plans Better Windows 11 RAM Management and a Smoother User Experience

Microsoft recently announced a plethora of changes coming to Windows 11 to reshape the operating system into a completely stable and enjoyable experience. Today we learn that Microsoft plans a major background usage overhaul with future updates, focusing on RAM usage and overall memory management, s...

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Mar 23 • 5:49 AM EDT • Technology • techpowerup.com
Third annual 'Hop into Health' draws families for free screenings and Easter fun

In Jacksonville Sunday afternoon, Onslow Memorial Hospital hosted a fun and free opportunity for families to enjoy activities like an Easter egg hunt, and take

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Mar 22 • 8:46 PM EDT • Health • wcti12.com
Your Thymus and Your Healthspan

Our thymus gland plays a central role in the development or our immune system, specifically for supporting T cell development (how these cells got their name, maturation and differentiation in the thymus) and discriminating between self and foreign, non-self antigen proteins with production of dendritic cells. As we age, our thymus gland shrinks—the process known as involution—with progressive change from spongy to fatty tissue, with loss of functionality. But this process, with respect to timeline and extent, markedly varies from one person to the next. And to make things even more complicated, our thymus gland anatomy and precise location in the chest also is highly variable. So the famous Frank Netter diagrams from the 1960s (such as at left below) don’t capture the remarkable heterogeneity that a random set of 12 chest CT scans (below at right). What I consider as 2 landmark papers in Nature this week (here and here) used AI to quantify health of the thymus in 2 large cohorts, and then correlate the metric to a broad array of health outcomes. In this edition of Ground Truths, I’m going to cover three questions: (1) How was thymus health determined by AI?; (2) How is thymus health linked to key clinical outcomes? and (3) Are there ways we can promote a healthy (aka rejuvenate) thymus gland in our later years? Subscribe 1. How was thymus health determined by AI? This was accomplished by extensive work developing and validating an AI pipeline for 2 stages, the first for localization and segmentation of the thymus bed, and the second to quantify a digital marker, termed the thymic health score. There’s a lot to this algorithmic development, so I won’t go into all the details, but just provide a rudimentary outline of what was done. The 1st stage used supervised learning with 2 radiologists reviewing 2,461 chest CT scans. That work trained a 3D U-Net model to automatically identify the thymic bed’s 3D cropped region using center of mass coordinates, which reached 99.8% accuracy. The 2nd stage used a foundation model that was pre-trained with SwAV (which stands for Swapping Assignment between multiple Views), a self-supervised model, that generated a high-dimensional thymus representation of 4,096 features. That compares to the radiology reductionist and subjective scoring of 0 to 3 where 0 means the thymus is fully degenerated and fatty, and 3 is considered dense, intact glandular soft tissue. Notably, the self-supervised learning (SSL) performance was superior to supervised (AUC ~0.75 vs 0.55, respectively) reflecting the shallowness of the 0-3 classifier vs SSL’s holistic, self-taught AI. The thymic health score ranged from 0 to 100, with the highest number indexed to fully preserved thymic health. The algorithmic work extended to explainability with both Shapely value distribution, meaning the model was holistic not relying on any “magic” pixel, and occlusion sensitivity, demonstrating the model’s performance was not affected by ribs, sternum, lung tissue, but rather focused on the thymic bed directly. Below are a few saliency maps from the occlusion sensitivity that indicate the thymic bed focus, not affected by neighboring structures, using the jet color scale. Now the AI was ready for processing ~25,000 CT scans, each over 30 MB files, from the 2 large participant cohorts to provide a thymic health score, it did so in less than 14 hours, which is less than 2 seconds per scan! Share 2. How is thymus health linked to key clinical outcomes? The two cohorts were the National Lung Screening Trial, NLST (N=25,031) and the Framingham Heart Study, FHS (N=2,581) each with baseline demographics and long term follow up of >12 years for health outcomes. From the NSLT, you can see below that increased age and body-mass index were correlated to reduced thymic health. And, overall, men had reduced thymic health scores compared with women. There are a lot of graphs in the paper for outcomes, for both the NLST and FHS cohorts. To simplify the major outcomes, below is a composite Figure with striking reduction of all-cause mortality and for the different causes of death. The results were consistent between the 2 cohorts. For example, the cardiovascular mortality hazard ratio average was 0.57 in NLST and 0.38 in FHS (weighted to be 0.53 for the aggregate). The reduction of mortality also extended to digestive diseases and pulmonary disease (data not shown below). Lung cancer incidence was reduced by 36% for high vs low thymic health (Figure below, with a panel -incidence and b panel-mortality, adjusted for age, sex, BMI, smoking status). Notably, there was a smoker’s paradox: lower incidence and improved survival for lung cancer in smokers who had a high thymus health score. Smoking was associated with lower thymic scores whereas alcohol was not. Higher thymic health was linked to higher HDL cholesterol, lower triglycerides, lower fasting blood glucose, and lower systolic and diastolic blood pressure. Inflammation biomarkers, such as C-reactive protein and interleukin-6, were elevated in the people with lower thymic health scores. In their second paper, the same team looked at the relationship between thymic score and outcomes for 3,476 patients receiving cancer immunotherapy. The non-small cell lung cancer progression-free survival was reduced in patients with low thymic health score. A parallel relationship for survival was seen for other types of cancer including melanoma, breast, and kidney with a 44% lower risk among high thymic scores (Figure). A similar pattern was seen with different immune checkpoint inhibitors. The thymus health score outperformed programmed death ligand-1 (PD-L1)and tumor mutation burden (TMB) assay of the tumor and was an independent prognostic marker of progression-free survival. In this dataset, a direct connect with thymus score and adaptive immune function was noted with a correlation before cancer treatment for both T-cell diversity and thymus T-cell production (a metric known as T cell receptor excision circles). Thymus Removal Study There is a highly relevant citation about thymus function before moving onto ways to rejuvenate it. In 2023, a very important study of thymus removal during cardiothoracic surgery was published, with 1146 patients undergoing thymus removal vs 1146 matched controls (mean age 55 years). The adverse outcomes for thymus removal were striking, with a 2.9 higher risk of all-cause mortality and doubling of cancer incidence, 1.5 fold increase in cancer mortality, and 1.5-fold increase in autoimmune diseases. The immune function showed marked compromise after thymus removal, as reflected by CD4+ and CD8+ T cells (Figure below) Share Ground Truths 3. Are there ways we can promote a healthy (aka rejuvenate) thymus gland in our later years? In recent months we’ve learned a lot about the process of thymus involution and the pathways by which this may be modulated. Thymus involution is primarily due to loss to thymus epithelial cells (TECs) and there are 2 subtypes with different functions: the cortical, responsible for positive selection of T cells, and the medullary, for negative selection. When adipose tissue infiltrates the thymus, thymic adipocytes are pro-inflammatory, knocking out T-cell output. Likewise, systemic inflammation, or “inflammaging,” from smoking, obesity, and chronic stress promote thymic adipocytes. Now, from preclinical studies, we know about key pathways that account for these processes. Historically, back in 2014, FOXN1 was recognized as a single master transcription factor essential for TEC function, with studies in mice with forced FOXN1 upregulation leading to thymus regeneration. That laid the foundation for potential regrowth of quiescent thymus cells. It took awhile to find pathways to accomplish this goal and to even refute its role as the master regulator. The Liver-Thymus Axis Feng Zhang and his team recently showed that injection of an mRNA vaccine to the liver encoding DLL1, IL-7 and FLT3-L in combination, factors known to support thymopoiesis (Figure), successfully enhanced immune function in aged mice. However, the effect was transient. The FGF21 Story Two reports in 2025 addressed the thymus gland’s production of FGF21, a growth factor (fibroblast growth factor 21) and its control of thymus involution. This growth factor is also produced by the liver, but it doesn’t have impact on the thymus in aged rodent models. In contrast, The liver’s hepatocyte growth factor (HGF) has been shown to reverse senescent TEC structural changes. Growth hormone stimulates production of insulin growth factor-1 (IGF-1) in the liver and the thymus. Two small studies in human participants (TRIIM, for Thymus Regeneration, Immunorestoration, and Insulin Mitigation) of 6 and 50 people, respectively, treated with combined human growth hormone, metformin and DHEA, suggested the potential of slowing epigenetic aging and improving thymus mass and function. But the combination of drugs, small sample, and lack of controls make conclusions murky. Increased thymus FGF21 led to increased CD8 T cells in old mice and extended healthspan and improved physical performance. Building on the previous FOXN1 data, ablation of β-klotho, the obligatory co-receptor for FOXN1, accelerated thymic aging. The benefit to FGF21 was confirmed in a companion paper using an FGF21 knock-in mouse model showing thymus enlargement and increased TECs throughout the lifespan. (schematic Figure below). The accompanying editorial for these 2 papers speculated: “The proposed link between age-associated thymus involution and organismal aging is intriguing, and suggests we might seek to achieve systemic rejuvenation by counteracting thymic involution.” Other Factors Lessons from the Axolotl (Mexican Salamander) In an elegant set of experiments of the axolotl (Figure), known for its complete thymus regeneration after total surgical removal, mediators were identified. Surprisingly FOXN1 was dispensable. But midkine, a growth factor, appeared to be the driver, the initiator of thymus cell growth, survival, and repair. Other components that contributed were Postn+ (periostin-expressing mesenchymal niches) and Ccl19, a chemokine protein from the bloodstream. RANK and RANKL RANK (receptor activator of nuclear factor κB its ligand (RANKL) have been considered key regulators of medullary TECs. In a study of both aged mice and human thymus cell cultures, their key role was confirmed, with multiple benefits of resorting TEC function, recruitment of progenitor cells, and T cell development. Subscribe Summing Up This body of work strongly supports the health of the thymus gland as a critical regulator of human healthspan, not just a correlate or link. The new landmark studies are reinforced by the regenerative biology experimental models that have shown, via an array of mediators, that healthspan of aged mice is at least in part dependent on thymus gland function and its critical role for maintaining adaptive immunity. It sure seems that we’d be better off having an immune reservoir of naive T cells instead of a profile in older adults of exhausted, low quality, memory T cells, with a senescent phenotype. It is striking that we ignored the importance of the thymus gland for many decades. A wake-up call was the results of the thymectomy matched control study reviewed here, with the opposite of high thymic health score improved health outcomes. The convergence of AI and healthspan here is notable. The exceptional and laborious work for developing and validating (no less explaining) the AI to quantify thymus health set the foundation for probing the connect the major health outcomes in two cohorts with extensive follow-up. We’ve never had a way to meaningfully quantify the thymus gland before, so this represents important leverage of supervised, self-supervised, and transformer models. The study wouldn’t have been possible without AI. And it begs the question as to whether there are ways we can maintain our thymus at a high health score. But it’s not so simple to rejuvenate our thymus. There are multiple risks including the induction of autoimmunity, increasing the risk of cancer, and inducing a pro-inflammatory state. For example, factors that increase TEC proliferation could compromise the medulllary negative selection process and leak out auto-reactive (self-attacking) T cells. Thymic cells could be induced to proliferate, but we know, for example, that growth hormone and IGF-1 are associated with an increase risk of cancer. If thymus rejuvenation doesn’t clear out the accumulated senescent cells in older adults, then inflammation within the gland could block the production of TECs. Keeping these risks in mind, we now have identified many ways to keep our thymus healthy as we age that undoubtedly will be tested in clinical trials going forward. Ultimately, the benefit-to-risk tradeoffs will be defined. In the meantime, we have desperately needed an immunome. As I’ve stressed in multiple prior Ground Truths, we have no test in the clinic to assess a patient’s immune status! It was very encouraging for me to get an email from Hugo Aerts, the senior author of the landmark papers in the days after they were published: “I also wanted to say that your Substack on “Why We Need an Immunome” was inspiring for this work. We found it a very compelling perspective and greatly enjoyed reading it.” Just having an assessment of a person’s immune status via a chest CT scan, with millions of these performed per year, might help in guiding the right immunotherapy for cancer (e.g. more intensive, combinations for those with low thymic health scores) and help define people who are increased risk for age-related diseases of cancer, cardiovascular, and neurodegenerative. The main theme of Super Agers is that we now have many layers of data (genetics, proteins, biomarkers, organ clocks that can be integrated via multimodal AI) for us to define a person’s specific risk decades before one of these age-related diseases leads to symptoms, enabling prevention. From the new studies this week, we can add thymus health score as yet another way to understand a person’s risk, a window into their adaptive immune system and healthspan. And perhaps someday we will be able to safely rejuvenate the thymus, or maintain its health through one’s life, and use the thymus health score to monitor. NB: I wrote this post (No A.I.) A Quick Poll Loading... ********************************************************************* Thanks to Ground Truths subscribers (now > 200,000) from every US state and 212 countries. Your subscription to these free essays and podcasts makes my work in putting them together worthwhile. Please join! If you found this interesting PLEASE share it! Share Ground Truths Paid subscriptions are voluntary and all proceeds from them go to support Scripps Research. They do allow for posting comments and questions, which I do my best to respond to. Please don’t hesitate to post comments and give me feedback. Let me know topics that you would like to see covered. Leave a comment Many thanks to those who have contributed—they have greatly helped fund our summer internship programs for the past two years. It enabled us to accept and support 47 summer interns in 2025! We aim to accept even more of the several thousand who will apply for summer 2026.

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Mar 22 • 2:18 PM EDT • Health • erictopol.substack.com
Finding Easter eggs in entertainment boosts enjoyment and fan behavior, study finds

If you've watched popular movies or television shows in the last decade, there's a good chance you've found an Easter egg or two: not an actual brightly colored egg but a subtle reference to another movie ...

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Mar 18 • 2:40 PM EDT • Entertainment • phys.org
Popcorn and Easter eggs

KU study finds when people spot Easter eggs in their movies, their enjoyment and fan behaviors are heightened.

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Mar 18 • 8:00 AM EDT • Entertainment • news.ku.edu
Thunder first NBA side to clinch play-off place

Shai Gilgeous-Alexander enjoys 40-point night as the Oklahoma City Thunder beat the Orlando Magic and become the first NBA team to secure a play-off berth.

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Mar 18 • 3:03 AM EDT • Sports • sports.yahoo.com
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Champions League live updates: Arsenal-Leverkusen, Man City-Real Madrid

Enjoy live updates from Tuesday's UEFA Champions League matches, including Arsenal vs. Leverkusen, Man City vs. Real Madrid and Chelsea vs. PSG.

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Mar 17 • 2:59 PM EDT • Sports • espn.com
Haims: Jujube(s) have health benefits for sleep, Parkinson’s and Alzheimer’s

If you’re old enough to remember enjoying a box of Jujubes at the movie theater, you’re old enough to question this article’s title. If not, here’s the scoop. For decades, Jujubes candy was a movie theater staple. They look like very short rabbit pellets, similar in size and...

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Mar 16 • 10:00 AM EDT • Health • aspentimes.com
Partisanship and science

I recently participated in a symposium of the Denver-based Institute for Science & Policy, during which I had a “fireside chat” with Tony Mills of the American Enterprise Institute. Mills has written extensively on the politicization of science, and the two of us had a very enjoyable hour-long conversation on the topic. You can watch it below. The main questions we dealt with are why there is such a vast partisan gap in trust of science, and to what extent this is a unique moment. Mills helpfully brings a good deal of data to the discussion, as he did in this useful piece at Issues in Science & Technology. Tusk depends on reader support. To support this work, please become a paid subscriber. Subscribe Note this graph, drawing on a range of survey data to demonstrate partisan attitudes toward science since 1970s. As it demonstrates, there’s been a very sharp partisan divergence in confidence in science during the Trump Era, starting prior to the Covid pandemic. At least in part, we can attribute this to a rise in populist anti-science rhetoric embraced by Trump, his appointees, and those in his media orbit. But as the graph also shows, the partisan divide has existed in the past, and it’s not always in the same direction. The largest divergence in party views toward science prior to 2016 was in the 1970s, when liberals equated scientific achievement with the military-industrial complex and thus trusted it less. That era of scientific mistrust is often overlooked. Indeed, as Mills notes, the Moon landings (1969-72), which today are considered one of the last great moments of national unity, were experienced nothing like that at the time. There was sharp debate back then over whether the Apollo missions were worth the vast expenditures when the country had so much else to deal with. It’s outside the dataset, and we don’t have the partisanship lens for it, but the 1950s was another deeply anti-science decade, with critics of intellectuals and college professors alleging their ties to communism and their lack of commitment to basic American moral beliefs. This was the subject of Richard Hofstadter’s 1962 book Anti-Intellectualism in American Life, in which he quotes religious leaders like Franklin Graham: [In place of the Bible] we substituted reason, rationalism, mind culture, science worship, the working power of government, Freudianism, naturalism, humanism, behaviorism, positivism, materialism, and idealism. [This is the work of] so-called intellectuals. Thousands of these “intellectuals” have publicly stated that morality is relative—that there is no norm or absolute standard.… This fervor was heavily whipped up by Sen. Joe McCarthy (R-Wisconsin), although it’s clear that not all his fellow Republicans were on board with his red-baiting. What ended that era? The simple answer is the 1957 launch of Sputnik. Americans became afraid that they were losing to Soviet scientists, and suddenly university researchers and government projects were awash with funding. In our conversation, I asked Mills about the possibility of us having a Sputnik moment again that would rally the American public in favor of science today. Mills argued that the COVID-19 pandemic was essentially a Sputnik moment — a terrifying threat to all Americans that required scientific advances to address. But thanks in part to political polarization and the populist and conspiratorial leanings of Donald Trump, we got the opposite of a unifying moment. Many Americans turned against science, despite science actually stepping up in that moment. As we discussed in the chat, it’s not clear what scientists could or should be doing in this moment to increase faith in their work. As Mills notes, one of the chief complaints against scientists and professors is that they’ve become too political; scholars becoming even more political might not help them achieve their goals. This (mainly Republican-driven) anti-science era will end, of course, but it’s not clear what event will bring that about. Share

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Mar 16 • 9:13 AM EDT • Science • smotus.substack.com
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Tinkatink Community Day April 2026: Shiny Odds, Bonuses & Gigaton Hammer Tinkaton

Trainers, get hyped! The next Community Day of 2026 stars Tinkatink, the Metal Hammer Pokémon! Join the event on Saturday, April 11, 2026, from 2:00 p.m. to 5:00 p.m. local time to enjoy 2x catch Candy, increased Tinkatink spawns, and a chance to encounter Shiny Tinkatink. Evolve Tinkatuff during the event—or up to four hours […]

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Mar 15 • 3:11 AM EDT • Technology • pokemongohub.net
What to Do in Vegas If You’re Here for Business (2026)

The secret to enjoying Vegas on a business trip is to go with the flow.

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Mar 13 • 7:37 PM EDT • Business • wired.com
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Winter Sports Wind Down

From the slopes to the squash courts, Colby athletes enjoyed a winter of record-setting sports accomplishments.

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Mar 13 • 8:44 AM EDT • Sports • news.colby.edu
MacBook Neo faces stiff competition this week — this Windows laptop with more RAM and storage is now $450 off if you're looking for better specs

The Acer Aspire 14 AI Laptop is a potent mid-range laptop fit for productivity tasks, and it's enjoying a rare 43% this week at Best Buy

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Mar 12 • 10:59 AM EDT • Technology • windowscentral.com
Bookman: Has the Kemp model fallen out of fashion in Georgia politics?

Brian Kemp, in his eighth and final year as governor, still enjoys significant popularity. In an Emerson poll conducted last weekend, only 24.5% of Georgians said they disapprove of his job performance, which in this divisive era is remarkable. You might think that kind of long-running success would make Kemp a model to be emulated […]

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Mar 12 • 4:00 AM EDT • Politics • georgiarecorder.com
Max Verstappen having conflicting thoughts on F1 retirement

The four-time world champion has a strong disliking towards the new F1 regulations and instead enjoys GT3 racing more

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Mar 12 • 2:50 AM EDT • Sports • sports.yahoo.com
St. Francis teacher Peter Graven on geology, curiosity, and a summer in Costa Rica

Peter Graven, a St. Francis science teacher, shares insights into his classroom, his passion for geology and what he enjoys outside of school.

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Mar 11 • 6:01 AM EDT • Science • jsonline.com
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New book finds light in ‘Darkness’ of eco-terror, ski-town politics and 90s newspaper intrigue

“We Bring you an Hour of Darkness” by Michael Bourne is a fun, fast-paced thriller for fans of the mystery genre, especially readers who enjoy ski-town tales of enviro-terror, corporate corruption, shady land deals and...

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Mar 10 • 10:44 PM EDT • Politics • vaildaily.com
Enjoy New Prizes and Newly Distributed Battle Boxes at Play! Pokémon Stores

Acrylic standees, stickers, and Battle Boxes are coming to local Play! Pokémon Stores starting April 1, 2026.

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Mar 10 • 8:00 PM EDT • Technology • pokemon.com
Chiefs’ breakout 2025 wide receiver rewarded with $11 million contract

The Chiefs have retained Tyquan Thornton for next season on Monday, enjoying his breakout campaign in 2025 as a standout receiver.

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Mar 10 • 12:27 AM EDT • Sports • sports.yahoo.com
Big Walk Preview: An Even Sillier Game from the Makers of Untitled Goose Game

After a very memorable first hour of playing Big Walk, the upcoming online co-op game from the makers of Untitled Goose Game, I’m absolutely sold on this as the next friendslop for my crew and I to jump in on. If it managed to be this enjoyable when all the puzzles were super simple, I can only imagine how ridiculous and memorable it’ll be when they introduce more complicated scenarios.

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Mar 9 • 9:00 AM EDT • Technology • ign.com
‘A little science in their life’: Sacramento residents enjoy Free Museum Weekend
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Mar 9 • 1:11 AM EDT • Science • yahoo.com
‘A little science in their life’: Sacramento residents enjoy Free Museum Weekend

(FOX40.COM) — Sacramento explorers put on their curiosity hats Sunday afternoon for the end of Free Museum Weekend. The annual event aims to ease access to the world of art, history and science — l…

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Mar 9 • 1:11 AM EDT • Science • fox40.com
Great Mills Graduate Dimitri Reeves Spreads Message Of Love Through Entertainment

GREAT MILLS, Md. — When you mention Dimitri Reeves in Southern Maryland, most people know exactly who he is. A graduate of Great Mills High School, Reeves is a renowned entertainer bringing communities together with his message of love and acceptance one moonwalk at a time. He has always enjoyed listening to singer, songwriter, dancer and […]

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Mar 8 • 6:00 AM EDT • Entertainment • thebaynet.com
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This pimped out 1000-hp Mercedes-Benz limo has absolutely massive turbos that are bigger than your face

This Mercedes-Benz limo not only drifts, but it has over 1,000hp and two turbochargers that are bigger than your face - and this content creator got to enjoy it

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Mar 7 • 9:07 PM EST • Technology • supercarblondie.com
4 Underrated Smart TV Features You Need To Start Using

Smart TVs make the entertainment watching experience more enjoyable, but it's the more extraneous features that may prove useful outside of just watching TV.

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Mar 7 • 12:17 PM EST • Technology • bgr.com
Summer of the Arts reveals 2026 free program lineup

Enjoy free entertainment all summer with the 2026 Friday Night Concert Series and Drive-in Movies at the Hangar. The programs foster a sense of community through music and film in Iowa City.

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Mar 7 • 7:00 AM EST • Entertainment • thegazette.com
Xbox Drops 2 AAA Free Games, No Game Pass Required To Play

Xbox users can enjoy 4 AAA games for free for a limited time, with 2 games not requiring a Game Pass subscription! Have a good weekend gamers.

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Mar 6 • 5:00 PM EST • Technology • gamingbible.com
Free Play Days – Call of Duty Black Ops 7, Sonic Racing: CrossWorlds, FBC: Firebreak and Black Desert

Free Play Days - enjoy Call of Duty Black Ops 7, Sonic Racing: CrossWorlds, FBC: Firebreak and Black Desert this weekend.

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Mar 5 • 11:00 AM EST • Technology • news.xbox.com
York coffee shop hosts 7am 'rave' for mental health group

Ravers enjoy a walk and then dance music with their morning coffee before going to work.

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Mar 5 • 7:04 AM EST • Health • bbc.com
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Peacock and NBC Sports Network Set to Broadcast BIG EAST Basketball Tournament Action

NEW YORK -- Fresh off NBC Sports' "Legendary February," with the network featuring BIG EAST basketball in addition to Super Bowl LX, the NBA All-Star game, and the Winter Olympics from Milan Cortina, the calendar has turned to March and the excitement of BIG EAST Men's and Women's Basketball Tournament play will enjoy comprehensive coverage on Peacock and NBC Sports Network.

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Mar 4 • 7:30 AM EST • Sports • bigeast.com
Poll: Almost across the board, Ron DeSantis is more popular than Donald Trump in Florida

The man in Tallahassee enjoys majority approval, but POTUS is underwater.

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Mar 4 • 5:30 AM EST • Politics • floridapolitics.com
Is platonic female friend killing my chances at love? Hax readers give advice.

Letter writer enjoys his close “asexual friendship” much more than dating but worries he will live to regret this choice.

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Mar 4 • 12:00 AM EST • Entertainment • washingtonpost.com
Mysterious Roman-era board game that eluded scientists for a century finally solved by AI

The cutting-edge gamebot, named Ludii, "played the game against itself and identified a few variants that are enjoyable for humans to play."

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Mar 2 • 12:27 PM EST • Science • nypost.com
Gunflint Trail lodges see boost in winter business after latest snowfall

A stretch of snowfall in recent weeks has put winter in Cook County and the northeast region back on familiar footing. The recent snowfall, totaling over two feet in some areas, has brought a resurgence of winter visitors eager to enjoy outdoor activities. “People are really happy,” said Ruth Wagner, owner of Golden Eagle Lodge....

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Feb 28 • 1:01 PM EST • Business • wtip.org
Your morning coffee could one day help fight cancer

Scientists at Texas A&M are turning an everyday pick-me-up into a high-tech medical switch. By combining caffeine with CRISPR gene editing, researchers have created a system that allows cells to be programmed in advance — and then activated simply by consuming a small dose of caffeine from coffee, chocolate, or soda. The approach, known as chemogenetics, lets scientists precisely turn gene-editing activity on and off inside targeted cells, including powerful immune T cells that can fight cancer.

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Feb 28 • 1:00 AM EST • Science • sciencedaily.com
“Heated Rivalry” season 2 to begin filming this summer, creator reveals premiere date

"Enjoy the yearn," executive producer Brendan Brady advised fans.

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Feb 26 • 11:45 AM EST • Entertainment • yahoo.com
Game Preview: New Jersey Devils @ Pittsburgh Penguins 2/26/2026

Who: New Jersey Devils (28-28-2, 58 points, 7th place Metropolitan Division) @ Pittsburgh Penguins (29-15-12, 70 points, 2nd place Metropolitan Division) When: 7:00 p.m. eastern How to Watch: Locally broadcast on Sportsnet Pittsburgh and MSG, streaming on ESPN+ Pens’ Path Ahead: Well, hopefully everyone enjoyed the time off because the schedule goes bonkers from here. This is […]

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Feb 26 • 7:00 AM EST • Sports • sports.yahoo.com
Letters to the Editor: I’ve received healthcare all over the world. The worst was in the U.S.

'Next time I need dental work, I'll fly to Buenos Aires, have my crown put on, stay a month, enjoy the malbec and I'll be money ahead,' writes an L.A. Times reader.

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Feb 25 • 8:00 AM EST • Health • latimes.com
Ron DeSantis doubts deal possible with 'tottering' Iran regime, thinks Donald Trump will 'follow through' with attacks

'They don't want to have a peaceful world like we would want to enjoy with our allies.'

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Feb 22 • 9:00 PM EST • Politics • floridapolitics.com
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Pokémon GO Events This Week: 23 February

Pokémon GO’s February 23 to March 1 week has us entering the final week of Precious Paths! Enjoy a bumper week of daily raid hours, the build up to Kalos Tour, and the epic Global Kalos Tour event! Plus the weekly rotating Spotlight and Raid Hours, Dynamax Battles and Mega Raids. ⭐Highlights Raid Boss Change […]

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Feb 22 • 6:21 AM EST • Technology • pokemongohub.net
Broaden your horizons at Atlanta Science Festival

Experience the wonders of science at the Atlanta Science Festival in March. Enjoy interactive events, explore different topics, and have fun!

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Feb 21 • 10:04 AM EST • Science • roughdraftatlanta.com
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I quit Airbnb and delisted my home after hosting nightmare guests

Wendy Martin's Airbnb property in Dayton, Ohio, made her money and she enjoyed hosting — until three bad experiences with guests made her quit.

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Feb 21 • 7:47 AM EST • Business • businessinsider.com