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Uplifting and Not Ceding Ground on Health Equity Practice Is Critical to Strengthening Public Health and the Health of the Nation
Public health science gains in the last quarter century in the United States have been formidable due to a focus on structural and social determinants of health, thereby enhancing understanding of the role of inequitable policies in shaping health inequities and inequitable access to ameliorative resources.
NRG CEO: Too early to change business models from impacts of war in Iran
Larry Coben, NRG CEO, joins 'The Exchange' to discuss managing NRG amid the energy landscape, pullbacks in energy use and much more.
The live-action 'Moana' trailer debuts Dwayne Johnson as Maui — and fans can't stop talking about his hair
The remake of the 2016 animated film hits theaters July 10.
Trump says talks are happening. Iran says they’re not. Why a former Trump Iran negotiator says both might be true
F1 CEO talks US growth as business accelerates
Formula One (F1) CEO Stefano Domenicali joins Yahoo Finance Executive Editor Brian Sozzi to discuss F1's rapid growth in the US market, new racing regulations, and more. Watch the video above to hear more on the sport's focus on expansion and entertainment.
Women's March Madness live updates, scores, results: Alabama leads Louisville in tightly contested first half; UConn, South Carolina, UCLA back in action Monday
Thousands in taxpayer funds spent on horse, hair and makeup expenses for Kristi Noem’s Mount Rushmore ad
Tens of thousands of taxpayer dollars were spent on expenses for hair and makeup artists and a horse for the advertisement showcasing outgoing Department of Homeland Security Secretary Kristi Noem in front of Mount Rushmore, according to invoices seen by CNN.
NBA MVP rankings: Luka Dončić is rising, but can anyone take the trophy from Shai Gilgeous-Alexander?
Linden Entertainment Signs ‘Your Friends & Neighbors’, ‘Tow’ Director Stephanie Laing
EXCLUSIVE: Linden Entertainment has signed Emmy-winning director, writer, and producer Stephanie Laing for management. Laing is coming off the theatrical release of her new film, Tow, a comedy-drama s...
Microsoft-backed startup raises $40 million for advanced chipmaking equipment tech
Lace, a Norway-headquartered chipmaking equipment startup which is backed by Microsoft, has raised $40 million in funding to further develop a technology that could enable significant advances in semiconductor design and manufacturing, the company said on Monday. To make cutting-edge chips, manufacturers such as Taiwan Semiconductor Manufacturing Co and Intel employ a process called lithography that uses light to draw complex circuits that form the foundation of advanced artificial intelligence chips. Manufacturers use light-based lithography systems made by the Dutch company ASML - which dominates the market - as they race to shrink chip components and squeeze in more features to boost the computing horsepower on a limited area of silicon.
Southcoast Community’s Choice Awards business spotlight: Perfect Smiles Dentistry
Nominations for the SouthCoast Community's Choice Awards are rolling in! Don't miss your chance to recognize your favorite local businesses.
Trump was offered an off-ramp to the DHS shutdown but he didn’t take it
President Donald Trump was presented Sunday with a potential off-ramp to the more than month-long Department of Homeland Security shutdown: fund every part of the department except enforcement operations by Immigration and Customs Enforcement, two sources familiar with the conversations told CNN.
Nominate a Capital Region health care executive who’s making a difference
Who’s running the organizations shaping health care in the Capital Region — and doing it well? That’s the question at the heart of the Outstanding Health Care Executive category in Business Report‘s inaugural Excellence in Health Care Awards. This recognition is for the senior leaders who are making the hard calls, building strong teams and […]
Revolutionary Submarine Mysteriously Disappears Without a Trace – Scientists Are Now Preparing for a Bold Return
A pioneering robotic submarine that explored beneath Antarctica’s glaciers has been lost, but its discoveries are reshaping our understanding of ice melt as a more advanced successor is prepared to continue the mission.
Roger Bennett of the Men in Blazers discusses the agony and the ecstasy of watching a penalty shootout
Kyler Murray Vikings Era Begins
Why Kyler Murray's stats say he could be Darnold 2.0 — plus free agency, the draft, and Harrison Smith's future.
When Vermont’s treatment landscape shifts, community providers step up
As Vermont’s substance use treatment landscape shifts, community providers are stepping up to maintain access to care. In Washington County, strong partnerships ensure rapid connection to treatment, recovery services, and coordinated support.
Supreme Court hears arguments in mail-in voting case
The Supreme Court is hearing arguments today in a case about whether states may count mail-in ballots received after Election Day. Follow here for live updates.
The week ahead: Another big (and tough) week for Penguins
Looking at what the Pittsburgh Penguins need to do to secure their spot in the Stanley Cup Playoffs this season.
Top architectural and historic preservation groups sue Trump over Kennedy Center plans
A consortium of the nation’s top architectural and historic preservation groups is targeting President Donald Trump’s plans to temporarily close and extensively renovate the Kennedy Center, filing a new lawsuit Monday that asks a federal judge to indefinitely halt the project.
Cowboys mock draft tracker: A trade might make sense early
How interested are you in trading back in the first round?
WSU launches bilingual video series to help beekeepers improve colony health
Researchers with WSU's Honey Bee and Pollinators Program have produced a new video series giving novice keepers a strong introduction to best practices and the science of apiculture, in both Spanish and English.
Jack Gibbens reflects on ‘bittersweet’ decision to leave Patriots
Gibbens signed a two-year deal with the Cardinals in free agency.
Blue Jays extend manager John Schneider, GM Ross Atkins following World Series appearance
The Blue Jays are locking up two architects of the team's World Series run.
Danone to buy protein shake maker Huel as health nutrition craze drives demand shift
Merging the companies is an opportunity in fast-growing nutrition space, said Danone CEO Antoine de Saint-Affrique.
Every NFL franchise's biggest position to improve, plus free agency and draft solutions
The Cowboys need to add to their defense, and they have the draft capital to make it happen.
Samsung's Galaxy S26 will get Apple AirDrop support starting today
The feature was first launched on Pixel 10 phones last year.
‘President Trump is right’: The White House’s go-to line about Trump’s false claims
President Donald Trump’s White House spokespeople have a favorite two-step reply when reporters ask them to comment on one of Trump’s false claims.
There’s little information about a large measles outbreak in Florida, so we went to see it
One of the largest measles outbreaks the US has seen in decades erupted at Ave Maria University in Florida, but very little information was being shared with the public. So CNN went to the small Florida town to learn what’s driving the case count.
Staff revolts, secret meetings: Inside the tense fight between Mike Pence and the Heritage Foundation
Mike Pence used to dream of following two successful Donald Trump terms with his own turn in the White House.
How AI therapies are changing health care
It may become harder to tell whether a compound or an algorithm is doing the healing.
Fertilizer prices bring more pain for American farmers amid war in Iran
The war in Iran is pushing up prices for already-strained farmers, with higher costs for fertilizer and energy on top of last year’s tariffs. And the increasing pressure on American agriculture could lead to even bigger price tags at the grocery store.
Leeds 0-0 Brentford
Paul: Leeds played as if they are frightened of losing rather than trying to win. Chris: Good point in the end - they are a good side pushing for a European place and have good players. Hopefully in the final run-in we will see more of Daniel James, Wilfried Gnonto and Noah Okafor, especially in the home games, to create more goals and keep us in the Premier League.
Tribune All-Area girls' basketball team full of winners
2025-26 Tribune All-Area girls' basketball team features a group of winners, boasting a ton of talent on the hardwood.
Ballard set to miss Northern Ireland's Italy play-off
Dan Ballard is set to miss Northern Ireland's crucial World Cup play-off semi-final against Italy on Thursday because of a hamstring injury.
Incredible offer signals Liverpool are all-in on Rio Ngumoha
An incredible offer of a player signals a real intent from Liverpool to go all-in on teenager Rio Ngumoha.Are Liverpool about to go all-in on Rio Ngumoha? They’ve been reluctant to do so this season...
Winners and losers from first weekend of the NCAA tournament feature John Calipari, Darryn Peterson, Big Ten and blue bloods
Devin Booker gets 100% on Suns’ playoff seeding chase
Devin Booker knows where the Suns sit amid their previous five-game skid and how it impacts the playoff seeding chase.
NCAA women's tournament takeaways, Day 3: Minnesota drains buzzer-beater as LSU, Texas dominate again
St. Louis Blues Weekly Prospect Report (March 22)
Jiricek has big scoring week; McIsaac announces future plans; Ralph, Michigan State head to NCAA Tournament with Mayich, Clarkson University eliminated; Peterson scored pair, including a SH beauty for Springfield
Power Play Primed – Hurricanes 5, Penguins 1
The Carolina Hurricanes scored three power play goals and dominated the Pittsburgh Penguins, 5-1 on Sunday afternoon in the Steel City. The Canes controlled the puck most of the game and were holding the Pens to a paltry 12 shots on goal until the Pens finally found some offense with five minutes and change to […]
NCAA tournament takeaways, Day 4: Big Ten's March Madness domination continues with 6 league teams making Sweet 16
Trump’s new red line could set the Iran war on a fateful course
On Friday, President Donald Trump said he was considering “winding down” his war with Iran. But a day later, he threatened to “obliterate” the country’s power plants in an escalation that could further tip the conflict out of control.
3 things to know about new 49ers punter Corliss Waitman
The San Francisco 49ers are replacing Thomas Morstead with Corliss Waitman. Let's get to know the team's new punter before he boots his first ball.
Michigan State basketball time, TV channel set for Sweet 16
Michigan State basketball knows when it will be playing, even before it knows its opponent in the Sweet 16 in Washington on Friday night.
Scientists Trap Light in a Layer 1,000x Thinner Than a Hair
Scientists have found a way to trap light in an extremely thin layer, potentially reshaping how future photonic devices are built.
Alvaro Folgueiras hits game-winner to lift Iowa past No. 1 Florida, into first Sweet 16 since 1999
Florida's hopes at back-to-back national titles are gone.
Statue of Christopher Columbus installed on White House grounds
A statue of Christopher Columbus has been erected outside of an ornate federal office building on the White House grounds — the latest sign of the Trump administration’s efforts to reshape cultural and historical representations across the nation’s capital.
Arizona Diamondbacks Spring Training Gameday Thread, #30 @ Padres
Roster moves The Arizona Diamondbacks made the following roster moves and have 33 players in camp. Optioned to Triple-A Reno: Reassigned to Minor League camp: The first of these is a bit of a surprise. Only yesterday, I was noting how Abner seemed to have the inside track for left-handers job, after the recent meltdowns […]
Kansas coach Bill Self unsure about future after buzzer-beater loss to St. John's: 'I haven't decided'
After a heartbreaking last-second loss in the second round of the NCAA tournament, Self wasn't ready to discuss his coaching future.
Jerry Hanlon, longtime Michigan football coach, dies at 96
"Michigan Athletics has lost one of the finest ambassadors and mentors our football program has ever known," U-M AD Warde Manuel said in a statement.
Two veteran relievers clinch jobs on Diamondbacks' Opening Day roster
Right-handers Jonathan Loaisiga and Joe Ross have made the Diamondbacks' roster for Opening Day. Both will pitch in relief.
The M-Trends 2026 report shows how to strengthen business cybersecurity.
Learn more about the evolving threat landscape based on Mandiant's new M-Trends 2026 cybersecurity report.
Ducks Sign Herman Träff to Entry-Level Contract
The 20-year-old had 41 points in 51 games this season for Oskarshamn in the HockeyAllsvenskan.
Oil prices rise after Trump issues ultimatum and Iran threatens to close the Strait of Hormuz indefinitely
Oil prices rose Sunday after President Donald Trump threatened to “obliterate” Iran’s power plants if the Strait of Hormuz is not reopened by Monday evening.
Jason Momoa forced to evacuate as devastating storm hits Hawaii
Thousands have been ordered to flee as the archipelago faces its most intense surge of storms in two decades.
Women's March Madness live updates, scores: LSU makes history in NCAA tournament; Minnesota stuns Ole Miss to advance to Sweet 16
The Cowboys are making a mistake with this move
The Cowboys still have to find help at linebacker.
Former acting ICE director under Obama shares concern about ICE airport deployment
Cockroaches with smart backpacks? Scientists turn insects into cyborgs to detect hidden pipeline leaks
Science News: Although the concept seems like something from science fiction, science is rapidly adopting it. Researchers have started creating ‘cyborg cockroaches,.
Bursaries open for help with sports memberships
Children meeting certain criteria can get up to £200 from Epsom & Ewell Borough Council.
Minnesota Wild, NHL mourn hockey writer Jessi Pierce after death in house fire
Pierce and her three children were killed in a house fire outside of Minneapolis early Saturday morning.
Full 7-round Arizona Cardinals mock draft simulation
We have a new 7-round mock draft for the Arizona Cardinals.
Student researchers bring Kentucky State University science to Posters-at-the-Capitol
With lawmakers just steps away, three Kentucky State University undergraduates presented research on cattle health, soil amendments and food safety at the Capitol Annex on March 5, bringing student-led agricultural […]
Kentucky Gov. Beshear takes jabs at JD Vance in his home state of Ohio
Kentucky Gov. Andy Beshear, speaking in JD Vance’s home state of Ohio on Saturday, tore into the vice president, questioning his Appalachian roots and telling voters they “deserve better.”
Crimson Desert developer apologizes and promises to replace AI-generated art
Pearl Abyss announced a comprehensive audit of its in-game assets and will replace any AI-generated content.
Your Thymus and Your Healthspan
Our thymus gland plays a central role in the development or our immune system, specifically for supporting T cell development (how these cells got their name, maturation and differentiation in the thymus) and discriminating between self and foreign, non-self antigen proteins with production of dendritic cells. As we age, our thymus gland shrinks—the process known as involution—with progressive change from spongy to fatty tissue, with loss of functionality. But this process, with respect to timeline and extent, markedly varies from one person to the next. And to make things even more complicated, our thymus gland anatomy and precise location in the chest also is highly variable. So the famous Frank Netter diagrams from the 1960s (such as at left below) don’t capture the remarkable heterogeneity that a random set of 12 chest CT scans (below at right). What I consider as 2 landmark papers in Nature this week (here and here) used AI to quantify health of the thymus in 2 large cohorts, and then correlate the metric to a broad array of health outcomes. In this edition of Ground Truths, I’m going to cover three questions: (1) How was thymus health determined by AI?; (2) How is thymus health linked to key clinical outcomes? and (3) Are there ways we can promote a healthy (aka rejuvenate) thymus gland in our later years? Subscribe 1. How was thymus health determined by AI? This was accomplished by extensive work developing and validating an AI pipeline for 2 stages, the first for localization and segmentation of the thymus bed, and the second to quantify a digital marker, termed the thymic health score. There’s a lot to this algorithmic development, so I won’t go into all the details, but just provide a rudimentary outline of what was done. The 1st stage used supervised learning with 2 radiologists reviewing 2,461 chest CT scans. That work trained a 3D U-Net model to automatically identify the thymic bed’s 3D cropped region using center of mass coordinates, which reached 99.8% accuracy. The 2nd stage used a foundation model that was pre-trained with SwAV (which stands for Swapping Assignment between multiple Views), a self-supervised model, that generated a high-dimensional thymus representation of 4,096 features. That compares to the radiology reductionist and subjective scoring of 0 to 3 where 0 means the thymus is fully degenerated and fatty, and 3 is considered dense, intact glandular soft tissue. Notably, the self-supervised learning (SSL) performance was superior to supervised (AUC ~0.75 vs 0.55, respectively) reflecting the shallowness of the 0-3 classifier vs SSL’s holistic, self-taught AI. The thymic health score ranged from 0 to 100, with the highest number indexed to fully preserved thymic health. The algorithmic work extended to explainability with both Shapely value distribution, meaning the model was holistic not relying on any “magic” pixel, and occlusion sensitivity, demonstrating the model’s performance was not affected by ribs, sternum, lung tissue, but rather focused on the thymic bed directly. Below are a few saliency maps from the occlusion sensitivity that indicate the thymic bed focus, not affected by neighboring structures, using the jet color scale. Now the AI was ready for processing ~25,000 CT scans, each over 30 MB files, from the 2 large participant cohorts to provide a thymic health score, it did so in less than 14 hours, which is less than 2 seconds per scan! Share 2. How is thymus health linked to key clinical outcomes? The two cohorts were the National Lung Screening Trial, NLST (N=25,031) and the Framingham Heart Study, FHS (N=2,581) each with baseline demographics and long term follow up of >12 years for health outcomes. From the NSLT, you can see below that increased age and body-mass index were correlated to reduced thymic health. And, overall, men had reduced thymic health scores compared with women. There are a lot of graphs in the paper for outcomes, for both the NLST and FHS cohorts. To simplify the major outcomes, below is a composite Figure with striking reduction of all-cause mortality and for the different causes of death. The results were consistent between the 2 cohorts. For example, the cardiovascular mortality hazard ratio average was 0.57 in NLST and 0.38 in FHS (weighted to be 0.53 for the aggregate). The reduction of mortality also extended to digestive diseases and pulmonary disease (data not shown below). Lung cancer incidence was reduced by 36% for high vs low thymic health (Figure below, with a panel -incidence and b panel-mortality, adjusted for age, sex, BMI, smoking status). Notably, there was a smoker’s paradox: lower incidence and improved survival for lung cancer in smokers who had a high thymus health score. Smoking was associated with lower thymic scores whereas alcohol was not. Higher thymic health was linked to higher HDL cholesterol, lower triglycerides, lower fasting blood glucose, and lower systolic and diastolic blood pressure. Inflammation biomarkers, such as C-reactive protein and interleukin-6, were elevated in the people with lower thymic health scores. In their second paper, the same team looked at the relationship between thymic score and outcomes for 3,476 patients receiving cancer immunotherapy. The non-small cell lung cancer progression-free survival was reduced in patients with low thymic health score. A parallel relationship for survival was seen for other types of cancer including melanoma, breast, and kidney with a 44% lower risk among high thymic scores (Figure). A similar pattern was seen with different immune checkpoint inhibitors. The thymus health score outperformed programmed death ligand-1 (PD-L1)and tumor mutation burden (TMB) assay of the tumor and was an independent prognostic marker of progression-free survival. In this dataset, a direct connect with thymus score and adaptive immune function was noted with a correlation before cancer treatment for both T-cell diversity and thymus T-cell production (a metric known as T cell receptor excision circles). Thymus Removal Study There is a highly relevant citation about thymus function before moving onto ways to rejuvenate it. In 2023, a very important study of thymus removal during cardiothoracic surgery was published, with 1146 patients undergoing thymus removal vs 1146 matched controls (mean age 55 years). The adverse outcomes for thymus removal were striking, with a 2.9 higher risk of all-cause mortality and doubling of cancer incidence, 1.5 fold increase in cancer mortality, and 1.5-fold increase in autoimmune diseases. The immune function showed marked compromise after thymus removal, as reflected by CD4+ and CD8+ T cells (Figure below) Share Ground Truths 3. Are there ways we can promote a healthy (aka rejuvenate) thymus gland in our later years? In recent months we’ve learned a lot about the process of thymus involution and the pathways by which this may be modulated. Thymus involution is primarily due to loss to thymus epithelial cells (TECs) and there are 2 subtypes with different functions: the cortical, responsible for positive selection of T cells, and the medullary, for negative selection. When adipose tissue infiltrates the thymus, thymic adipocytes are pro-inflammatory, knocking out T-cell output. Likewise, systemic inflammation, or “inflammaging,” from smoking, obesity, and chronic stress promote thymic adipocytes. Now, from preclinical studies, we know about key pathways that account for these processes. Historically, back in 2014, FOXN1 was recognized as a single master transcription factor essential for TEC function, with studies in mice with forced FOXN1 upregulation leading to thymus regeneration. That laid the foundation for potential regrowth of quiescent thymus cells. It took awhile to find pathways to accomplish this goal and to even refute its role as the master regulator. The Liver-Thymus Axis Feng Zhang and his team recently showed that injection of an mRNA vaccine to the liver encoding DLL1, IL-7 and FLT3-L in combination, factors known to support thymopoiesis (Figure), successfully enhanced immune function in aged mice. However, the effect was transient. The FGF21 Story Two reports in 2025 addressed the thymus gland’s production of FGF21, a growth factor (fibroblast growth factor 21) and its control of thymus involution. This growth factor is also produced by the liver, but it doesn’t have impact on the thymus in aged rodent models. In contrast, The liver’s hepatocyte growth factor (HGF) has been shown to reverse senescent TEC structural changes. Growth hormone stimulates production of insulin growth factor-1 (IGF-1) in the liver and the thymus. Two small studies in human participants (TRIIM, for Thymus Regeneration, Immunorestoration, and Insulin Mitigation) of 6 and 50 people, respectively, treated with combined human growth hormone, metformin and DHEA, suggested the potential of slowing epigenetic aging and improving thymus mass and function. But the combination of drugs, small sample, and lack of controls make conclusions murky. Increased thymus FGF21 led to increased CD8 T cells in old mice and extended healthspan and improved physical performance. Building on the previous FOXN1 data, ablation of β-klotho, the obligatory co-receptor for FOXN1, accelerated thymic aging. The benefit to FGF21 was confirmed in a companion paper using an FGF21 knock-in mouse model showing thymus enlargement and increased TECs throughout the lifespan. (schematic Figure below). The accompanying editorial for these 2 papers speculated: “The proposed link between age-associated thymus involution and organismal aging is intriguing, and suggests we might seek to achieve systemic rejuvenation by counteracting thymic involution.” Other Factors Lessons from the Axolotl (Mexican Salamander) In an elegant set of experiments of the axolotl (Figure), known for its complete thymus regeneration after total surgical removal, mediators were identified. Surprisingly FOXN1 was dispensable. But midkine, a growth factor, appeared to be the driver, the initiator of thymus cell growth, survival, and repair. Other components that contributed were Postn+ (periostin-expressing mesenchymal niches) and Ccl19, a chemokine protein from the bloodstream. RANK and RANKL RANK (receptor activator of nuclear factor κB its ligand (RANKL) have been considered key regulators of medullary TECs. In a study of both aged mice and human thymus cell cultures, their key role was confirmed, with multiple benefits of resorting TEC function, recruitment of progenitor cells, and T cell development. Subscribe Summing Up This body of work strongly supports the health of the thymus gland as a critical regulator of human healthspan, not just a correlate or link. The new landmark studies are reinforced by the regenerative biology experimental models that have shown, via an array of mediators, that healthspan of aged mice is at least in part dependent on thymus gland function and its critical role for maintaining adaptive immunity. It sure seems that we’d be better off having an immune reservoir of naive T cells instead of a profile in older adults of exhausted, low quality, memory T cells, with a senescent phenotype. It is striking that we ignored the importance of the thymus gland for many decades. A wake-up call was the results of the thymectomy matched control study reviewed here, with the opposite of high thymic health score improved health outcomes. The convergence of AI and healthspan here is notable. The exceptional and laborious work for developing and validating (no less explaining) the AI to quantify thymus health set the foundation for probing the connect the major health outcomes in two cohorts with extensive follow-up. We’ve never had a way to meaningfully quantify the thymus gland before, so this represents important leverage of supervised, self-supervised, and transformer models. The study wouldn’t have been possible without AI. And it begs the question as to whether there are ways we can maintain our thymus at a high health score. But it’s not so simple to rejuvenate our thymus. There are multiple risks including the induction of autoimmunity, increasing the risk of cancer, and inducing a pro-inflammatory state. For example, factors that increase TEC proliferation could compromise the medulllary negative selection process and leak out auto-reactive (self-attacking) T cells. Thymic cells could be induced to proliferate, but we know, for example, that growth hormone and IGF-1 are associated with an increase risk of cancer. If thymus rejuvenation doesn’t clear out the accumulated senescent cells in older adults, then inflammation within the gland could block the production of TECs. Keeping these risks in mind, we now have identified many ways to keep our thymus healthy as we age that undoubtedly will be tested in clinical trials going forward. Ultimately, the benefit-to-risk tradeoffs will be defined. In the meantime, we have desperately needed an immunome. As I’ve stressed in multiple prior Ground Truths, we have no test in the clinic to assess a patient’s immune status! It was very encouraging for me to get an email from Hugo Aerts, the senior author of the landmark papers in the days after they were published: “I also wanted to say that your Substack on “Why We Need an Immunome” was inspiring for this work. We found it a very compelling perspective and greatly enjoyed reading it.” Just having an assessment of a person’s immune status via a chest CT scan, with millions of these performed per year, might help in guiding the right immunotherapy for cancer (e.g. more intensive, combinations for those with low thymic health scores) and help define people who are increased risk for age-related diseases of cancer, cardiovascular, and neurodegenerative. The main theme of Super Agers is that we now have many layers of data (genetics, proteins, biomarkers, organ clocks that can be integrated via multimodal AI) for us to define a person’s specific risk decades before one of these age-related diseases leads to symptoms, enabling prevention. From the new studies this week, we can add thymus health score as yet another way to understand a person’s risk, a window into their adaptive immune system and healthspan. And perhaps someday we will be able to safely rejuvenate the thymus, or maintain its health through one’s life, and use the thymus health score to monitor. NB: I wrote this post (No A.I.) A Quick Poll Loading... ********************************************************************* Thanks to Ground Truths subscribers (now > 200,000) from every US state and 212 countries. Your subscription to these free essays and podcasts makes my work in putting them together worthwhile. Please join! If you found this interesting PLEASE share it! Share Ground Truths Paid subscriptions are voluntary and all proceeds from them go to support Scripps Research. They do allow for posting comments and questions, which I do my best to respond to. Please don’t hesitate to post comments and give me feedback. Let me know topics that you would like to see covered. Leave a comment Many thanks to those who have contributed—they have greatly helped fund our summer internship programs for the past two years. It enabled us to accept and support 47 summer interns in 2025! We aim to accept even more of the several thousand who will apply for summer 2026.
The Boston Celtics are terrifying to their opponents again
Instead of mailing it in for a season, the Celtics have rebuilt themselves into a contender again against all odds.
Syracuse reportedly targeting former player Gerry McNamara as its next men's basketball coach
NCAA men's bracket live updates, scores: Purdue vs. Miami leads off March Madness Sunday; Duke, Florida, UConn return to court
Breaking down Bills’ selections in latest NFL mock drafts
According to the latest NFL mock drafts, the Bills could go wide receiver, linebacker, safety, or defensive linemen at pick 26.
Kennedy’s latest MAHA-approved plan could supercharge peptide boom
He indicated that the FDA will soon widen access to the small proteins, which biohackers tout as therapies for a range of ills
Chiefs’ 2026 NFL Mock Draft roundup after NFL Free Agency
A closer look at the Chiefs’ 2026 mock draft outlook after free agency, with linked to edge help, cornerback, and offensive line support.
Home health aides epitomize a key problem in the current job market
About 4 million people were employed as home health and personal care aides in 2024. They earn just $16.78 an hour, despite the need for their services being intense.
‘Trump should keep his reckless mouth shut’: Jeffries responds to Trump calling Democrats America’s ‘greatest enemy’
Homan says ‘more conversations need to be had’ to end standoff over ICE, DHS funding
Bash: Trump celebrating Mueller’s death ‘not a surprise, but that doesn’t make it okay’
Maine progressive Senate candidate Graham Platner responds to Gov. Janet Mills’ attack on his online past
Bucs facing a tough decision with Baker Mayfield in 2026
The Bucs have to get the contract situation with Baker Mayfield solved sooner rather than later.
NFL Network: What's next for Bills QB Josh Allen? (video)
NFL Network roundtable looks ahead to Josh Allen and the Bills in 2026.
Titans sign ex-Browns linebacker
The Titans have signed former Browns linebacker Mohamoud Diabate to a contract after he wasn't tendered as an RFA.
‘The Comeback’ took on Hollywood long before ‘The Studio.’ Now, Valerie Cherish will have her curtain call
“The Comeback” was by no means the first series to hold a funhouse mirror up to the entertainment industry, but the comedy starring co-creator Lisa Kudrow, which returns for its final season on Sunday, has certainly always done it in its own navel-gazing yet endearing way.
Chicago Cubs news and notes
#Cubs, #MLB, and #MiLB news.
I left Goldman Sachs to build a small baking business. Here's how my time at the firm is giving me a leg up.
NFL draft injury analysis: Caleb Downs, S
Caleb Downs medical report
In Maine’s marquee Senate primary, Janet Mills reaches out to women by raising Graham Platner’s online past
Janet Mills and her allies are counting on a gender gap to narrow Platner’s wide lead ahead of the June 9 primary to decide who will face incumbent Republican Sen. Susan Collins. They are betting that the unfiltered style that has brought Platner widespread attention as someone who could help Democrats reach young men will backfire with women.
Game Preview: Carolina Hurricanes @ Pittsburgh Penguins 3/22/2026
Who: Carolina Hurricanes (44-19-6, 94 points, 1st place Metropolitan Division) @ Pittsburgh Penguins (35-18-16, 86 points, 2nd place Metropolitan Division) When: 3:00 p.m. eastern How to Watch: Locally broadcast on Sportsnet Pittsburgh and FDSN South, streaming on ESPN+ Pens’ Path Ahead: Quality opponents await in the next week; the Pens host Colorado on Tuesday, an Avs team […]
Scouting Future Saints: Washington wide receiver Denzel Boston
Denzel Boston might not be the most popular name among receivers in the draft, but he's among the most talented and he could fit what the Saints need.
Flexitarian and the MIND included in top diets for a healthy brain, according to U.S. News
Discover four top diets that may support sharper focus, steadier mood, and long-term brain resilience
What time is Michigan women's basketball's second round game?
Michigan cruised to a blowout victory over Holy Cross in their opening NCAA Women's Tournament matchup. See who they play next.
49ers News: 25 more Sundays until NFL football is back
Your daily San Francisco 49ers news for Sunday, March 22nd, 2026