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Business First: Q3 Earnings Snapshot
(AP) — Business First Bancshares, Inc. (BFST) on Monday reported third-quarter profit of $24.
S.T.A.L.K.E.R. 2: Heart of Chornobyl version 2.1 update ‘The Zone Lookout’ now available
GSC Game World has released the version 2.1 update “The Zone Lookout” for post-apocalyptical first-person shooter S.T.A.L.K.E.R. 2: Heart of Chornobyl.
Brazil's Lula celebrates election victory as Bolsonaro rejects results
Luiz Inacio Lula da Silva has won a historic fourth term after defeating far-right rival Flavio Bolsonaro in a runoff election. It's a remarkable political comeback for Lula who trailed in the first round.
Georgia’s first health care charter school helps students explore careers in medicine
Russia to stage World Weightlifting Championships, first major hosting since full-scale Ukraine invasion
The International Weightlifting Federation announced on Sunday that the 2030 world championship event would take place in Moscow.
Scientists solve mystery of 1,000-mile cloud floating on Mars
Space enthusiasts and astronomers have been tracking one of the Red Planet’s most fascinating atmospheric mysteries for years: a colossal plume officially known as the Arsia Mons Elongated Cloud (AMEC). AMEC was first discovered in 2018 and quickly became one of the most elusive answers for scientists. Researchers have now resolved this mystery using the […] Read the original article here: Scientists solve mystery of 1,000-mile cloud floating on Mars
Student code takes the wheel in Formula 110’s simulated races - College of Arts and Sciences
In a packed lecture hall, first-time programmers raced simulated self-driving cars and got a robotics lesson from the provost. The cars were virtual. The cheering was not.
Rice engineering students become first university group inside Apple’s new Advanced Manufacturing Center
Rice University materials science and nanoengineering students gained hands-on experience in AI server production and surface-mount technology during an exclusive tour of Apple’s new Advanced Manufacturing Center in Houston.
New Allied Health Concentration Fuses Healthcare Delivery with Emerging Technologies
The new Digital Health and Technology concentration gives UConn students firsthand experience with the tools transforming modern healthcare and build skills ...
Kite appreciates second chance after Exeter return
Harry Kite hopes he can repay Exeter City's faith in him after his first league start since re-joining the club.
Nintendo Switch 2 gets its first list of Xbox achievements with Minecraft
Minecraft launches on Nintendo Switch 2 on October 27 and includes its own set of Xbox achievements to unlock on Nintendo's console.
Think your boss is bad? Scientists identify history’s first official ‘corporate psychopath’
People motivated by power, wealth, and personal advancement were attracted to capitalism from its earliest days
Linn County Public Health releases annual report
The report highlights the department’s response to a 2025 measles exposure case, its first annual adaptive sports clinic and other ongoing initiatives.
NFL Week Seven: 2 Underrated Takeaways
NFL Week Seven’s Sunday slate has concluded, and there is plenty to speak of. The week featured a couple of firsts. The Miami Dolphins got their first win of the season, while the San Francisco 49ers and Kansas City Chiefs suffered their first losses. Those are the major stories. I’m going to focus on some […] The post NFL Week Seven: 2 Underrated Takeaways appeared first on Stadium Rant.
Exclusive: Health tech PE megadeals surge as deal volume drops
The average health care buyout size jumped to $3.4 billion in the first half of 2026.
Soham Basanwar wins three honors in international computer science competition
Indian American Illinois university junior finished first in the senior category and U.S. national category.
Analysis | Saddam’s Cheesecake Factory: Trump’s predecessors go after him in ways only they can
In today’s edition … Voters are changing their minds … You tell me about your first time voting … but first …
Mental health event aims to support those who serve and protect
“Resilience: From Service to Strength” is an Oct. 27 Rockledge event focused on mental health for veterans, military and first responders.
Apple Music unveils logo that was physically “made by sound”
Apple has revealed the first rebrand for its Apple Music service, which was made in collaboration with musician Fred Again by passing sound waves through a pool of oil.
New Orleans-based biotech company lured to SC as first for MUSC lab
The company name was deliberately chosen from West African lore: Obatala, the god who shaped the human body. And the New Orleans biotech firm is determined to see that their human-based research lab m...
Smithsonian scientists launch "Lumina" simulation to model early universe
Researchers introduce "Lumina," a massive cosmological radiation-hydrodynamics simulation designed to model the universe's first two billion years
How to watch the Tennessee governor's forum, and who's attending
“This is the first time in eight years Tennessee voters will elect a new governor and it’s important the public hear from the major candidates.\
Ebola scientists to probe Nigeria case origin, Africa CDC says
By Jennifer Rigby LONDON, Oct 26 (Reuters) - A team of leading Ebola scientists will travel to Nigeria to help investigate how the country’s first patient in more than a decade got infected, Africa CDC Director-General Jean Kaseya said. Their task will...
Patrick Mahomes Puts Chiefs on Notice After Career-Worst Performance
Kansas City Chiefs quarterback Patrick Mahomes shared a brutally honest take after his team lost to the Seattle Seahawks. The post Patrick Mahomes Puts Chiefs on Notice After Career-Worst Performance appeared first on HEAVY.
Seahawks Jaxon Smith-Njigba Delivers Simple Message After Beating Chiefs
Seattle Seahawks wide receiver Jaxon Smith-Njigba had a simple message after his team beat the Kansas City Chiefs. The post Seahawks Jaxon Smith-Njigba Delivers Simple Message After Beating Chiefs appeared first on HEAVY.
Ballon d'Or 2026: Harry Kane, Kylian Mbappe and Lamine Yamal in race for men's award
Harry Kane, Lamine Yamal and Kylian Mbappe battling for 2026 mens Ballon dOr on Monday; Kane odds-on favourite to become first Englishman to win the award in 25 years; Lamine Yamal, 19, aiming to become youngest-ever Ballon dOr winner; Sky Sports Jamie Carragher backing Kane to win
Cole Caufield’s Canadiens claim will surely divide fans across Canada
The Montreal Canadiens are having a fine start to the 2026-27 NHL season. Cole Caufield and his teammates are looking to return to the Stanley Cup Playoffs. In outdoor conditions on Sunday, Caufield was a big star for the Habs against the Winnipeg Jets. The Canadiens defeated the Jets 2-1 in the Heritage Classic at Princess Auto Stadium in […] The post Cole Caufield’s Canadiens claim will surely divide fans across Canada appeared first on ClutchPoints.
Cris Collinsworth Turns Heads With Unusual Praise of Patrick Mahomes
Announcer Cris Collinsworth was criticized after he praised Chiefs quarterback Patrick Mahomes for recovering a fumble. The post Cris Collinsworth Turns Heads With Unusual Praise of Patrick Mahomes appeared first on HEAVY.
HVEN Inbound: Dream 2 Science
Deep house duo Dream 2 Science play their first live show in Japan at HVEN in Nakameguro, Tokyo, on November 6.
Chiefs Announce Historic Travis Kelce News During Seahawks Game
Kansas City Chiefs tight end Travis Kelce can’t stop making NFL history.With his third reception in the fourth quarter against the Seattle Seahawks on Sunday night, Kelce has passed Hall of Famer Tony Gonzalez for the most receiving yards by a tight end ever, including the postseason, with 13,342.Kansas City Chiefs’ Travis Kelce is Most […] The post Chiefs Announce Historic Travis Kelce News During Seahawks Game appeared first on HEAVY.
Students and artificial intelligence industry leaders connect at inaugural Michigan AI Business Conference
More than 250 students, professors and industry leaders gathered Friday for the first Michigan Artificial Intelligence Business Conference at the Ross School of Business.
Mike Brown Drops Blunt Quote After Knicks Lose to Magic
New York Knicks head coach Mike Brown dropped a blunt quote after the Knicks lost to the Orlando Magic 111-102 on Sunday night.The start to the new NBA season has not gone well for New York, which is 0-3 to begin the season. Considering this team just won the NBA Championship back in June, it’s […] The post Mike Brown Drops Blunt Quote After Knicks Lose to Magic appeared first on HEAVY.
Will Apple's overhauled MacBook Pro finally offer 5G cellular support?
This week, Apple will be overhauling the MacBook Pro for the first time since 2021. OLED, touch support, and a...
14-year-old Ngozi Wright makes feature film début
At just 14 years old, Ngozi Muzik Wright adds another milestone to an impressive performing arts journey that began when she was barely old enough to speak. The gifted young Jamaican, whose commanding dub poetry performances have captivated audiences at home and throughout the diaspora, has stepped on to the big screen in her first full-length feature film, From A Yardie To A Yankee.
Lorna Goodison wins 2026 Derek Walcott Prize for Poetry
Celebrated Jamaican poet Lorna Goodison has added another prestigious international honour to an already distinguished literary career, winning the 2026 Derek Walcott Prize for Poetry for her ground-breaking new translation of the 14th-century classic, Dante’s Inferno. Goodison, Jamaica’s first female Poet Laureate, serving from 2017 to 2020, receives the US$2,000 prize for a work that boldly transports Dante’s epic journey into a Caribbean landscape, drawing deeply on Jamaican language, culture, history and identity.
‘Resident Evil’ film resurrects horror game franchise
The first “Resident Evil” game came out in 1996, and since then, the franchise has been working to bring zombies, creatures and deadly outbreaks to life. For the newest piece,
‘End game’: Taylor Swift and Travis Kelce mocked by opponent
The Seattle Seahawks handed the Kansas City Chiefs their first loss of the season on Sunday night, and they made sure to rub it in afterward by trolling newlyweds Travis Kelce and Taylor Swift. After their 20-3 win on Sunday Night Football, the Seahawks posted a Swift-themed troll on social media, sharing a friendship bracelet…
Frustrated Broncos RB Refuses Interviews Following Cardinals Win
The Denver Broncos' veteran running back stormed out of their locker room following Week 7's win over the Arizona Cardinals. The post Frustrated Broncos RB Refuses Interviews Following Cardinals Win appeared first on HEAVY.
How Lula beat Bolsonaro, broke records and halted the right-wing wave aligning Latin America with Trump in 20 days
Luiz Inácio Lula da Silva made history on Sunday, setting a record for Brazil and the rest of Latin America by becoming the first president to win a fourth term – and he did so days before turning 81, an age when many other leaders decide to leave politics behind.
Raptors’ Kawhi Leonard to undergo testing after concerning injury update
Kawhi Leonard was missing in action on Sunday, as the Toronto Raptors lost to the Minnesota Timberwolves , 117-94, at Target Center. The Raptors fell to 2-1, while the Timberwolves improved to 3-0. Leonard was added to the injury report just an hour before tip-off. Toronto announced that the veteran forward was dealing with swelling in his left […] The post Raptors’ Kawhi Leonard to undergo testing after concerning injury update appeared first on ClutchPoints.
Norman Silverman to Open First Flagship Store in Beverly Hills
Los Angeles diamond jeweler Norman Silverman is opening its first flagship store at The Maybourne Beverly Hills in December.
Dana White Outlines How Movsar Evloev Gets Another Title Shot
UFC president Dana White outlined how featherweight fighter Movsar Evloev could get another title shot at 145 lbs.Evloev was 20-0 in MMA and 10-0 in the UFC heading into UFC 333, but he suffered a brutal second-round knockout loss against UFC featherweight champion Alexander Volkanovski in a failed bid to become the promotion’s new 145 […] The post Dana White Outlines How Movsar Evloev Gets Another Title Shot appeared first on HEAVY.
Daniel Cormier Says Alexander Volkov Should Get UFC Title Shot
UFC commentator Daniel Cormier says that Alexander Volkov deserves to be next in line to fight for the UFC heavyweight title. Volkov — who turned heads this week with a viral clip of him asking UFC president Dana White what he has to do to get a title shot — defeated Rizvan Kuniev at UFC […] The post Daniel Cormier Says Alexander Volkov Should Get UFC Title Shot appeared first on HEAVY.
76ers veteran briefly raises alarm with injury scare vs. Pistons
The injury hits kept coming around the NBA on Sunday evening , but the Philadelphia 76ers seemingly avoided catastrophe with veteran guard Kentavious Caldwell-Pope. The veteran guard exited the game briefly , as per Adam Aaronson of The Philly Voice, with an apparent injury. While was initially tended to by team staff and accompanied back to the […] The post 76ers veteran briefly raises alarm with injury scare vs. Pistons appeared first on ClutchPoints.
Travis Kelce’s Physical Appearance Turns Heads Before Seahawks Game
Kansas City Chiefs star Travis Kelce made waves with his appearance in Seattle before Sunday's game against the Seahawks. The post Travis Kelce’s Physical Appearance Turns Heads Before Seahawks Game appeared first on HEAVY.
Observations after shorthanded Sixers fall to 1st loss of season
The shorthanded Sixers fell to their first loss of the season on Sunday night.
World-First Cancer Vaccine Cuts Melanoma Recurrence or Death Risk by 42% in Landmark Trial
"This has not been achieved before in the history of cancer drug development."
TWICE's Nayeon to make solo comeback with 'NA-sty' on Nov. 20
Na-yeon of K-pop girl group TWICE will release her new solo project, “NA-sty,” on Nov. 20, marking her first solo comeback in about two years and f...
Deshaun Watson does just enough to guide Browns past Titans
Deshaun Watson threw for over 300 yards for the first time since the 2020 season in Week 7 against the Titans.
Celtics’ Joe Mazzulla Addresses Growing Tatum-Brown Tension
For years, Boston Celtics fans have wondered whether Jayson Tatum and Jaylen Brown were friends off the basketball court. Following Brown’s recent comments to the media, it’s become clear that even if they were, that isn’t the case anymore.On Sunday, October 25, Celtics’ head coach Joe Mazzulla was asked about Brown’s recent comments regarding Tatum […] The post Celtics’ Joe Mazzulla Addresses Growing Tatum-Brown Tension appeared first on HEAVY.
Georgia lands son of music star in notable recruitment win
Georgia football secured a notable win during its bye week Sunday. And in the process, coach Kirby Smart and company win over fans of country star Luke Bryan. That’s because his son Bo Bryan is joining the 2027 recruiting class. The three-star quarterback chose the Bulldogs officially, becoming the newest College Football Recruiting win for […] The post Georgia lands son of music star in notable recruitment win appeared first on ClutchPoints.
Luka Doncic 50-Bomb Keeps Lakers’ Perfect Start Intact
Los Angeles Lakers guard Luka Doncic recorded a 52-point double-double in the Lakers' 132-123 win over the Utah Jazz on Sunday. The post Luka Doncic 50-Bomb Keeps Lakers’ Perfect Start Intact appeared first on LA Sports Report.
Lions QB Jared Goff Ties NFL History Against Rival Packers
The Detroit Lions are back in action on Sunday afternoon at Ford Field against the divisional rival Green Bay Packers in a clash that will carry heavy implications for the NFC North standings. And thanks to yet another strong start from quarterback Jared Goff, he’s not only put his club in a position to pick […] The post Lions QB Jared Goff Ties NFL History Against Rival Packers appeared first on HEAVY.
Rams Return to Winning Ways With Statement Win Over Raiders
The Los Angeles Rams beat the Las Vegas Raiders, 35-21, on Sunday, winning a game for the first time since Week 4. The post Rams Return to Winning Ways With Statement Win Over Raiders appeared first on LA Sports Report.
Four Positives From Frustrating Start To New Orleans Pelicans Season
These are some of the biggest positives to take away from the first few games of the New Orleans Pelicans' season.
Wizards at Hornets Preview: Washington heads south to Charlotte
Wizards head to Charlotte for their first matchup against the Charlotte Hornets this season.
Peyton Manning’s Role in Colts GM Search Clarified After Chris Ballard Firing
Peyton Manning is one of the greatest players, if not the greatest, to ever play for the Indianapolis Colts. The former quarterback is one of the most decorated players in American football history. He has won the Super Bowl two times, and is a five-time NFL Most Valuable Player. The Colts have not found the […] The post Peyton Manning’s Role in Colts GM Search Clarified After Chris Ballard Firing appeared first on Gridiron Heroics.
Supercomputer reveals first two billion years of ‘cosmic web’
The Center for Astrophysics’s simulation offers the most detailed look yet at the infancy of the universe after the Big Bang
6 stellar images of the early universe
The most detailed simulation of our universe’s first 2 billion years to date.
Tiny magnetic vortices could help computers work more like your brain
Scientists have filmed tiny magnetic vortices called skyrmions melting out of an organized lattice for the first time, revealing new ways to manipulate these unusual structures. The breakthrough could help make brain-like computers a reality, potentially enabling dramatically smaller and more energy-efficient technology.
Columbiana County Health District approve first reading of food service fees
LISBON — The proposed food service fees for next year through the Columbiana County Health District appear to be staying the same or decreasing from this year’s fees, with two more readings required for passage. The county health district board held first reading on the proposed fees on Wednesday, along with first reading on environmental […]
First round of 2026 high school football playoff matchups announced
Several area schools will play in the first round of the 2026 high school football playoffs this week.
"Tomb Raider: Legacy of Atlantis" 30th Anniversary Trailer
A new trailer is out for “Tomb Raider: Legacy of Atlantis,” the reimagining of the original 1996 first “Tomb Raider” game. Created in Unreal Engine 5, it offers fresh visuals, skill trees, and an expanded Atlantis story that will tie in the various eras of Lara Croft together. As Lara, harness your wits and athleticism […]
LeBron James Fires Off Message After Browns’ Latest Win
LeBron James fired off a message after the Cleveland Browns’ latest escape agains the Tennessee Titans. The post LeBron James Fires Off Message After Browns’ Latest Win appeared first on HEAVY.
Elon Musk’s Grok Imagine Releases First Odyssey Episode With Wonder Studios
8 sources compared: Other (4), Western Mainstream (3), Latin American (1). Elon Musk’s Grok Imagine released the first episode of its AI-generated series “The Odyssey,” posting a seven-minute vid...
Chiefs vs. Seahawks live updates, inactives, where to watch: Kenneth Walker III faces Seattle for first time since Super Bowl MVP run
6 stats from Barcelona 1-2 Real Madrid
A first away Clásico win in three years
What’s going on with AJ Dybantsa’s ankle injury?
The Washington Wizards have started off playing well this season, and they’ve done so without the No. 1 overall pick. AJ Dybantsa hasn’t made his NBA debut yet as he deals with an ankle injury, and it looks like he’ll have to keep waiting after the latest update on his status, according to Brett Siegel of ClutchPoints. “AJ Dybantsa will remain […] The post What’s going on with AJ Dybantsa’s ankle injury? appeared first on ClutchPoints.
Early voting underway in Michigan
Early voting began Saturday, Oct. 24 in Michigan. County officials say the first day of early voting went well and more than half of mail-in ballots have already been returned.
Race Results: 2026 NASCAR Cup Series YellaWood 500 at Talladega
Kyle Larson took a thrilling win in a wild last-lap rally that led to a photo-finish with William Byron, his Hendrick Motorsports teammate. Larson, who was eighth heading down the backstretch of the final lap, had everything go his way ahead of him, as he sliced and diced his way back to the front. Ricky […] The post Race Results: 2026 NASCAR Cup Series YellaWood 500 at Talladega appeared first on TobyChristie.com.
Vikings’ Aaron Jones Exits Colts Contest With Scary-Looking Injury
The Minnesota Vikings saw running back Aaron Jones Sr. go down with a leg injury late in their Week 7 game against the Indianapolis Colts. The post Vikings’ Aaron Jones Exits Colts Contest With Scary-Looking Injury appeared first on HEAVY.
49ers' First Loss Makes It Clear: Their Toughest Opponent Is Their Health
The 49ers picked up their first loss of the season on Sunday, but it wasn't what the Falcons did that caused them to stumble.
Walnut Ridge business starts coat drive for community
The Farm Service Tire Center in Walnut Ridge is hosting its first-ever coat drive, running now through Dec. 21.
Bengals Shut out in Disastrous First Half vs Ravens
The Cincinnati Bengals are off to a first half they’d like to forget. Cincy trails the Baltimore Ravens 13-0 in Baltimore.The story has been the Cincinnati Bengals’ defense which has been struggling against this Ravens offense.The Ravens got off to a hot start as Zay Flowers took a 48-yard pass to the house from backup […] The post Bengals Shut out in Disastrous First Half vs Ravens appeared first on HEAVY.
British Columbia's new premier lucks into the job in unexpected political turn
An electoral gamble by the Canadian province's outgoing premier, David Eby, backfired as the provincial Conservatives take power for the first time since 1928.
BC's new premier lucked into the job in an unexpected political turn
An electoral gamble by the Canadian province's outgoing premier, David Eby, backfired as the provincial Conservatives take power for the first time since 1928.
Here's how Bengals' second half vs Ravens made NFL history
The Cincinnati Bengals became just the 10th team in NFL history to get shut out in the first half and then score 35 points or more in the second half.
Here's how Bengals' second half vs Ravens made NFL history
The Cincinnati Bengals became just the 10th team in NFL history to get shut out in the first half and then score 35 points or more in the second half.
Remembering Freddie Freeman’s Iconic Walk-Off Grand Slam
Los Angeles Dodgers first baseman Freddie Freeman hit one of the most important home runs in Dodgers history two years ago, today.
USC Drops Out of AP Top 25 Poll After Wisconsin Loss, UCLA Rises Again
Both the USC Trojans and the UCLA Bruins had their rankings in the Associated Press Top 25 poll following their results from Saturday. View this post on Instagram A post shared by LA Sports Report (@lasportsreport) What Happened to USC’s Ranking? Following their loss to Wisconsin on Saturday, USC dropped out of the Top 25. […] The post USC Drops Out of AP Top 25 Poll After Wisconsin Loss, UCLA Rises Again appeared first on LA Sports Report.
Kaine, Randall tour county's new Crisis Receiving and Stabilization Center
The Loudoun County Crisis Receiving and Stabilization Center's first day of operations on Oct. 22 included a tour by Sen. Tim Kaine, D-Va., and county Board of Supervisors Phyllis J.
Heidi Klum frightens fans, teases Halloween costume with bizarre close-up of strange prosthetic
The Queen of Halloween herself Heidi Klum is offering fans a first look at this year’s Halloween costume. As usual, it involves some pretty bizarre prosthetics.
Nintendo reveals why you don't actually fight Bowser in Super Mario Bros. 1
Nintendo’s Shigeru Miyamoto has shared some insight into why players don’t actually fight Bowser in the original Super Mario Bros. Miyamoto was present at a press conference at the end of the week to celebrate him becoming the first developer to win Japan’s Order of Culture award. During the event, he was asked to share behind-the-scenes stories about the making...
Knicks Have Clear Advantage Over Magic With Lopsided Injury Report
The New York Knicks look for their first win of the season.
Google's privacy policy now has a loophole for using your Gmail and Photos data in ads
The change sits in Google's updated privacy policy, which took effect on October 16 and was first spotted by Android Authority. The policy has long said, "We...
Elon Musk’s Grok Releases First AI-Generated “Odyssey” Episode
Months after Elon Musk promised that Grok Imagine would make an entirely AI “Odyssey” film, the tech mogul has partially followed through.
Lakers at Jazz: What to watch in first road game
Walker Kessler needed only two games to show how much he could change the Los Angeles Lakers' frontcourt.
Steelers beat Saints to win first NFL game in Paris
The Pittsburgh Steelers defeated the New Orleans Saints 16-10 on Sunday to win the first-ever NFL regular season game in Paris. The low-scoring game had only one touchdown for each team.
Clayface Takes First Place While Holmes Documentary Grows in Week Two
Clayface opened with $24.5M, while A24's three-hour Elizabeth Holmes documentary You Can See Everything grew 25% in its second weekend.
Lakers 1st-Round Draft Pick Floated as Trade Piece
The Los Angeles Lakers are off to a fast start. Could it be time to weigh trading away some young pieces to boost the rotation? The post Lakers 1st-Round Draft Pick Floated as Trade Piece appeared first on HEAVY.
ESMO: Roche touts ‘convincing’ phase 3 KRAS data after win over rivals
Roche has shed more light on its investigational KRAS G12C inhibitor's phase 3 victory over Amgen’s Lumakras and Bristol Myers Squibb’s Krazati. The open-label Krascendo 1 trial enrolled 338 people with previously treated KRAS G12C-mutated non-small cell lung cancer (NSCLC). Patients who had already received a KRAS G12C inhibitor or pan-KRAS/RAS inhibitor were excluded from the trial. Participants received either divarasib once daily, Lumakras once daily or Krazati twice daily. Roche announced back in July that divarasib had demonstrated statistically significant improvements in progression-free survival (PFS) and overall survival (OS), meeting the trial’s primary and key secondary endpoints. But the Swiss pharma had been holding back the detailed data until now. At the European Society for Medical Oncology (ESMO) Congress in Madrid, Roche revealed that median OS for the 167 patients who received divarasib was 17.7 months, compared to 12 months for the 171 patients who received Lumakras or Krazati. The benefit was similarly clear when it came to median PFS, which stood at 9.8 months versus 5.7 months, respectively. A total of 44% of patients receiving divarasib were alive without disease progression at one year, compared to 24% of the control group, according to Roche’s presentation. It was a similar story for the objective response rate, which came in at 58% for divarasib versus 32% for the control group, while median duration of response was 11.9 months versus 6.9 months. Stefan Frings, M.D., Ph.D., deputy chief medical officer at Roche Pharma, told Fierce that the data made for a “very comprehensive, strong package, which should be convincing to health authorities.” “It’s an important advance for patients with lung cancer,” Frings said in an interview at a Madrid hotel during the conference. “It's a second-line setting, and patients who receive divarasib benefit compared to the current first-generation KRAS G12C inhibitors by having far longer overall survival,” he continued. “They live longer. They have better progression-free survival, better response rates, and with a safety profile which is—if [anything]—even better,” he said. According to Roche, 4.8% of patients receiving divarasib discontinued treatment due to treatment-related adverse events, compared to 11.7% in the control group. Serious treatment-related adverse events were also less common with divarasib, at 7.8% versus 15.2%. Roche’s confidence in divarasib had been building even before this phase 3 success. The candidate had already shown better potency and selectivity than the incumbent KRAS G12C inhibitors Krazati and Lumakras in preclinical tests. After cross-trial comparisons suggested that the edge translated into better clinical outcomes, Roche axed a study comparing divarasib to the chemotherapy docetaxel and went toe-to-toe with Lumakras and Krazati. “We designed the drug on purpose with higher potency and better selectivity,” Frings explained. “So, based on preclinical models, we clearly knew it would be superior to the first generation.” “It’s honestly not so frequent that pharma companies go head-to-head,” he added. “But if you want to make a point, if you want to convince payers, prescribers and patients … then a head-to-head win is rather rewarding.” While Amgen and BMS reached the regulatory finish line first for KRAS G12C-mutated, locally advanced or metastatic NSCLC in 2021 and 2022, respectively, they have struggled to capitalize on their head start. Krazati brought in $55 million for BMS in the second quarter, while Lumakras delivered $111 million to Amgen. For its part, Roche is aiming for peak divarasib sales of 1 billion to 2 billion Swiss francs ($1.2 billion to $2.5 billion), according to Frings. The Big Pharma is currently recruiting patients into a phase 3 trial comparing divarasib plus Keytruda against Keytruda plus chemotherapy in previously untreated advanced or metastatic nonsquamous KRAS G12C-mutated NSCLC. Roche has previously suggested that sales in metastatic disease would account for most of the forecast. Frings was tight-lipped on the exact timeline for a regulatory filing but said the Swiss pharma is “certainly keen to get this to as many patients as possible around the world.” Roche has more RAS drugs coming up behind divarasib. The pharma has already launched phase 1 trials of a pan-RAS inhibitor called RG6505 and a KRAS G12D inhibitor dubbed RG6620 in solid tumors. Roche’s partner Chugai Pharmaceutical is also testing a pan-KRAS inhibitor called AUBE00. Roche has made a “deliberate effort” to test a range of RAS drugs, Frings said. “If you have many rare mutations and you are scrambling to find sufficient patients, a pan-RAS inhibitor makes a lot of sense,” he explained.
Cam Skattebo Update: Will Giants Star RB Play Against Texans?
New York Giants share news on RB Cam Skattebo after benching in Week 6. The post Cam Skattebo Update: Will Giants Star RB Play Against Texans? appeared first on HEAVY.
Evaluating DJ Herz After Bouncing Back from Injury with Nationals
After making his first MLB appearance in nearly two years, what should the Washington Nationals expect from DJ Herz in his third season with the organization?
Jayson Tatum Reacts to Encouraging Celtics Development Against Knicks
The Boston Celtics beat the New York Knicks 107-103 on Friday night at TD Garden. Jayson Tatum scored 36 points and closed the game with a run that sealed the win. The stat line told the obvious story.But after the game, the moment Tatum wanted to talk about was not one of his own. It […] The post Jayson Tatum Reacts to Encouraging Celtics Development Against Knicks appeared first on HEAVY.
Amid first 0-3 start since 2007, Giannis-led Heat searching for answers: ‘We’re not in panic mode’
The Heat’s Giannis Antetokounmpo era is off to a rough start.
Preview
The Men's First Team are back in Serie A action, this time heading south to face Lecce in Puglia.The Serie A Matchday 8 clash is set to take place at the Stadio Via del Mare at 18:00 CET on Sunday, Oc...
Hints About Why Sabres Missed Connor Hellebuyck
The fact that the Buffalo Sabres missed out on Connor Hellebuyck could linger painfully for a while if the goalie play in Western New York doesn’t improve in a hurry. It’ll hurt all the more because the reports over the summer indicated that for at least a time, the Sabres were the frontrunners to pull […] The post Hints About Why Sabres Missed Connor Hellebuyck appeared first on HEAVY.
Business Briefcase: Open-air downtown farm market continues
SHENANDOAH — Schuylkill County’s longest running seasonal outdoor downtown farm market continues its popular run 8 a.m. to noon Tuesdays and Fridays through November along the east side of the first block of South Main Street. Launched in t…
Tickets on sale now for 49 Winchester's Charlottesville show next year
49 Winchester, a homegrown Virginia country rock band, is the first band announced for Ting Pavilion's 2027 lineup. Tickets are on sale now.