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Results for " DST " 717 found 🔀 AI-powered Shuffle

Saints give no guarantees for futures of 2 franchise greats

The New Orleans Saints are in the midst of transitioning into the future. That began last season, when the team was in a rebuilding year that culminated with Tyler Shough giving hope for the future. This year, the next step…

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Apr 22 • 2:01 PM EDT • Sports • sports.yahoo.com
Morehead State Engineering Tech earns top ATMAE accreditation

MSU celebrates its engineering programs, achieving the maximum ATMAE accreditation, reflecting high-quality education and strong job-placement outcomes.

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Apr 22 • 1:38 PM EDT • Science • moreheadstate.edu
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AMD Stock Jumps on the Launch of the Ryzen 9 9950X3D2 Dual Edition

AMD stock rallied on Wednesday alongside the launch of the Ryzen 9 9950X3D2 Dual Edition.

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Apr 22 • 11:11 AM EDT • Technology • tipranks.com
The Gunther Werks 'Project Endgame' Turbo Speedster Is a Truly Heroic 911-Based One-Off

Gunther Werks doesn't want to name the owner, but I'm willing to bet they won't be too hard to unmask.

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Apr 22 • 9:00 AM EDT • Technology • roadandtrack.com
Scene Calendar: 5th Avenue Arts Festival, live music at Heartwood

The 46th annual 5th Avenue Arts Festival will take place April 25-26. Ani DiFranco will perform at Heartwood Soundstage at 7 p.m. April 26

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Apr 22 • 5:02 AM EDT • Entertainment • gainesville.com
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Comedian Paula Poundstone will get political and personal at the Englert

Poundstone discusses her stand-up career as a nearly five-decade veteran comic ahead of her show at the Englert on Friday, April 24.

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Apr 20 • 11:32 AM EDT • Entertainment • thegazette.com
Viking Sports Weekly {April 20}

This Week's Events

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Apr 20 • 7:42 AM EDT • Sports • csuvikings.com
Child Caregivers Face Mental Health Crisis Amidst Medicaid Cuts

Over 5.4 million child caregivers in the U.S. face rising rates of anxiety and depression as proposed Medicaid cuts threaten in-home support.

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Apr 20 • 12:38 AM EDT • Health • mindsitenews.org
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Chicago Heights woman overcomes health issues to earn nursing degree

Nursing student Beatrice Agbayewa of Chicago Heights will receive her degree from Rasmussen University, overcoming migraines.

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Apr 19 • 6:15 AM EDT • Health • chicagotribune.com
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A New Museum in California Aims to Draw Children to Science

The $7 million KidSTREAM museum was the brainchild of a former teacher looking for a place to entertain her young daughters.

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Apr 19 • 5:00 AM EDT • Science • nytimes.com
Father, young daughter build business caring for headstones across northwest Ohio

OAK HARBOR, Ohio — Grave care isn’t something most families think about until they’re searching for a headstone they can barely find. “I was visiting my ...

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Apr 19 • 2:56 AM EDT • Business • toledoblade.com
Highlights: Steph Curry drills 4-point play vs. Clippers

In signature fashion, Steph Curry drilled a 4-point play amidst a furious run in the third quarter against the Clippers.

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Apr 17 • 12:22 PM EDT • Sports • sports.yahoo.com
Inside the CDC’s leadership vacuum: work at a ‘standstill’ and low morale as 80% of top posts remain vacant

Current and ex-officials at the CDC warn Americans’ health security in danger under RFK Jr’s direction

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Apr 17 • 6:00 AM EDT • Health • theguardian.com
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Offenses for Mets, Cubs trending in opposite directions entering series

The New York Mets are mired in their worst offensive slump in almost a decade -- just in time to meet the Chicago Cubs, who are in the midst of a much-needed lineup revival.

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Apr 16 • 4:39 PM EDT • Sports • cbssports.com
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Deadline Hollywood

CBS Entertainment Chief Addresses 'Watson' & 'DMV' Cancellations: "We Had To Make Tough Decisions" Read more below.

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Apr 16 • 3:03 PM EDT • Entertainment • facebook.com
Deadline Hollywood

CBS Entertainment President Amy Reisenbach explains why they went with 'NCIS: New York' and did not consider picking up 'Tony & Ziva' for next season. Read more below.

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Apr 16 • 4:00 AM EDT • Entertainment • facebook.com
Lynch Scholarship assists Ashland-area business majors

Discover the David A. Lynch Scholarship Endowment at Morehead State University, supporting aspiring students pursuing higher education in business.

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Apr 15 • 12:51 PM EDT • Business • moreheadstate.edu
Attorney says suspect in attack on OpenAI CEO's home was in midst of 'mental health crisis'

The man accused of trying to kill OpenAI CEO Sam Altman by throwing a Molotov cocktail at his San Francisco home was experiencing a mental health crisis and has been overcharged by prosecutors, his public defender said Tuesday.

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Apr 14 • 8:08 PM EDT • Health • pbs.org
🙂 Positive (35%)
This simple change stops robot swarms from getting stuck

In crowded environments, more robots don’t always mean faster results—in fact, too many can bring everything to a standstill. Harvard researchers discovered a surprising fix: adding a bit of randomness to how robots move can actually prevent gridlock and boost efficiency. By allowing robots to “wiggle” slightly instead of marching in straight lines, they can slip past each other and keep tasks flowing smoothly.

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Apr 14 • 8:00 PM EDT • Science • sciencedaily.com
Suspect Was in Apparent Mental Health Crisis During Attack on Sam Altman’s House

The San Francisco Public Defender’s office said 20-year-old Daniel Moreno-Gama was in the midst of acute mental illness when he attacked the OpenAI CEO’s home and offices, and was “overcharged” by local and national authorities.

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Apr 14 • 7:09 PM EDT • Health • kqed.org
Viking Sports Weekly {April 14}

This Week's Events

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Apr 14 • 11:12 AM EDT • Sports • csuvikings.com
Zuby Ejiofor and Bryce Hopkins Named College Sports Communicators Academic All-Americans - St. John's University Athletics

QUEENS, N.Y.- St. John's men's basketball student-athletes Zuby Ejiofor and Bryce Hopkins have been named to the College Sports Communicators (CSC) All-Ameri...

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Apr 14 • 8:00 AM EDT • Sports • redstormsports.com
Miles Across MedStar Health 200-Mile Run Launches In Southern Maryland, Spans DC To Baltimore

A 200-mile Miles Across MedStar run launched from MedStar St. Mary’s Hospital in Leonardtown, promoting movement, wellness and chronic disease prevention across Southern Maryland, DC and Baltimore.

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Apr 13 • 3:14 PM EDT • Health • thebaynet.com
FULL SHOW: Inside INdiana Business 4/12/26

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Apr 12 • 8:00 AM EDT • Business • insideindianabusiness.com
Illinois football hosts Mom’s Weekend practice

CHAMPAIGN, Ill. (WCIA) — Illini football took a break from the traditional spring practice for one that featured a special twist. Amidst mom’s weekend on the U of I campus, players’ moms took to the practice field with their sons for a second straight season. These football families are grateful for the quality time together […]

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Apr 12 • 12:20 AM EDT • Sports • sports.yahoo.com
In praise of popular science

As a kid, I was enthusiastically and unreservedly in favor of a manned space program. Our destiny lay in the stars, I figured. Get people out there. We need Star Trek here and now. As I got older, I became rather disenchanted with the idea. Humans are expensive, fragile, and inefficient as space cargo. We could flood the solar system with 100 robotic probes for the price of any single manned mission and get back just as useful data. Besides, it turns out space travel is dangerous. Tusk is a reader-supported publication. To support this work, please become a paid subscriber. Subscribe When it came to the recent Artemis II mission, my cynical side didn’t really see the point. Flying around the Moon and back is literally something we did before I was born, and I once owned a Members Only jacket. Apollo 8 circled the Moon ten times and returned to Earth safely the same month that “Chitty Chitty Bang Bang” was released. What was the point of repeating a feat that far braver people once did with tin foil and slide rules? Yet I’ve surprised myself with how moving I’ve found the Artemis II mission to be. The photos have been stunning. The crew has been professional and engaging. There have been modest but important milestones — the farthest humans have travelled from Earth; the first woman, person of color, and non-American to leave low-Earth orbit; innovations in communication, and more. One thing that really stood out is that this is really NASA at its finest. Not that this is the most important mission they ever pulled off, but they did this in a competent way that celebrated the achievements and kept the crew and the science at the forefront of the project. This wasn’t some billionaire throwing celebrities or cars into orbit as a vanity project — this was a collective effort to send experts in to do a job and come home safely. We don’t see that sort of thing much these days. I’m guessing few people would describe many government agencies as inspiring, but this one counts for me. We’re living through a profoundly anti-science era, in which pathbreaking, lifesaving discoveries like mRNA vaccines are routinely downplayed or even vilified. As I’ve noted previously, this era is something like that of the Red Scare in the 1940s and 50s, in which “egghead” professors were portrayed as out of touch or even hostile to regular Americans. One of the things that helped break that spell was Sputnik — the Soviet communications satellite that demonstrated that the United States was falling behind in crucial scientific research and applications. Its launch triggered a new appreciation for American science and goaded the federal government into supporting research universities and labs. I’m not saying that Artemis is the equivalent of Sputnik, but it potentially reminds people that there’s some value to scientific endeavors and the human faces attached to them. Despite my love for the show “For All Mankind,” I’m far from convinced that there’s any real value to putting colonies on the Moon or Mars that would justify the capital investment and the massive health risks to the astronauts. But sending scientific good will ambassadors on a trip into space once in a while? Bring it. Share

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Apr 10 • 9:54 PM EDT • Science • smotus.substack.com
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GlassWorm Campaign Uses Zig Dropper to Infect Multiple Developer IDEs

GlassWorm uses a fake WakaTime VS Code extension to infect IDEs, deploy RATs, and steal data, prompting urgent credential rotation.

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Apr 10 • 9:23 AM EDT • Technology • thehackernews.com
Boston 25 News

Spring sports season is here, and for millions of kids, that means teammates, competition, and time on the field, and the benefits can last a lifetime.

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Apr 10 • 8:10 AM EDT • Sports • facebook.com
😐 Neutral (0%)
Seafood restaurant, entertainment venue to open on Rose Bay

This Rose Bay restaurant is in the midst of revival, says owners Dino and Victoria Maxwell, soon reopening with fresh seafood, Putt-Putt and more.

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Apr 10 • 5:08 AM EDT • Entertainment • news-journalonline.com
Hackers drain local jewelry business of its Shopify account

A local online jewelry business says hackers drained its Shopify account to 18 cents, leaving sales, restocks and shipping at a standstill.

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Apr 9 • 8:42 PM EDT • Business • kob.com
O’Keefe named chair of Engineering Sciences

Dr. Jen O'Keefe was appointed chair of Morehead State University's Engineering Sciences, emphasizing research excellence and student mentorship in diverse programs.

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Apr 9 • 2:50 PM EDT • Science • moreheadstate.edu
😐 Neutral (0%)
Featured Grandstand Entertainment Announced for Second Weekend of This Year’s Clay County Fair

Spencer, Iowa (KUOO) — All-Star Monster Trucks, Outlaw Truck and Tractor Pull, and Figure 8 races will be the featured grandstand entertainment for the second weekend of this year’s Clay […]

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Apr 7 • 4:22 PM EDT • Entertainment • kiwaradio.com
Featured Grandstand Entertainment Announced For Second Weekend Of This Year’s Clay County Fair

(Spencer)– All-Star Monster Trucks, Outlaw Truck and Tractor Pull and Figure 8 races will be the featured grandstand entertainment for the second weekend of this year’s Clay County Fair. All-Star Monster Trucks will put on two shows Saturday, September 19th, with the Outlaw Truck and Tractor Pull performing under the lights that same evening. Figure […]

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Apr 7 • 12:35 PM EDT • Entertainment • exploreokoboji.com
Casper Planet

It’s a science day today 💪

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Apr 7 • 7:51 AM EDT • Science • facebook.com
Hess Midstream: The Issue Continues To Be The Bakken Upstream Business

Hess Midstream (HESM) faces Bakken risks as high costs and flat 200k BOED output limit growth while Chevron shifts capital. Read the latest analysis on the stock here.

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Apr 6 • 4:28 PM EDT • Business • seekingalpha.com
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Viking Sports Weekly {April 6}

This Week's Events

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Apr 6 • 6:49 AM EDT • Sports • csuvikings.com
Voters in Georgia have moved on from Marjorie Taylor Greene. On Tuesday, they finally fill her seat

Three months after Marjorie Taylor Greene abruptly left Washington in the midst of a remarkably bitter feud with President Donald Trump, voters in northwest Georgia on Tuesday are poised to cast their ballots – again – in a runoff election to replace her.

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Apr 6 • 5:00 AM EDT • Politics • cnn.com
76ers lose Cameron Payne to hamstring injury amid playoff chase

The Philadelphia 76ers are in the midst of a chase to clinch a spot in the NBA playoffs, but they just suffered a loss to their a core member of their bench.

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Apr 5 • 10:03 PM EDT • Sports • sports.yahoo.com
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FULL SHOW: Inside INdiana Business 4/5/26

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Apr 5 • 8:00 AM EDT • Business • insideindianabusiness.com
Golden Knights make the Pacific Division much more interesting

When the Vegas Golden Knights hired John Tortorella amidst a challenging stretch of play, many fans and pundits expressed curiosity and a dash of skepticism about if the change was going to awaken the sleeping giant.

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Apr 5 • 12:52 AM EDT • Sports • sports.yahoo.com
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Governor Michelle Lujan Grisham

It's back, Albuquerque! The New Mexico Museum of Natural History & Science reopens today, April 4th after eight months of renovations! Expect a revamped lobby, the brand-new Animal Armor traveling...

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Apr 4 • 12:43 PM EDT • Science • facebook.com
Tiger Sports Update: LSU Gymnastics home regional, Softball and Baseball prep for road games

The end of the semester is near for students, but LSU sports is still in the midst of their busy season. LSU Gymnastics is hosting their first regional since 2019, and the team is prepped for postseason success. The key to success for the Tigers will be to maintain what they’ve been doing all season...

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Apr 2 • 10:20 PM EDT • Sports • lsureveille.com
Morehead State names Dr. Steve Fenster as dean of College of Science & Engineering

An academic leader with a track record of over 20 years of student success in the sciences will now take on a key role at Morehead State University. Dr. Steve Fenster, dean of the School of Arts and Sciences at Fort Lewis College in Durango, Colorado, will serve as the next dean of the College of Science & Engineering at MSU, succeeding Dr. Ahmad Zargari, who will retire on June 30. To learn more about programs in MSU’s College of Science & Engineering, email dsci@moreheadstate.edu or call 606-783-2626.

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Apr 2 • 3:22 PM EDT • Science • moreheadstate.edu
LMPD forms task force to police Bardstown Road, entertainment areas

As the weather warms, Louisville officials are vowing that they will not tolerate behavior that they say threatens public safety.

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Apr 1 • 2:18 PM EDT • Entertainment • courier-journal.com
Target Just Launched a Flash LEGO Sale for Spring That's Actually Really Good, But It Only Lasts Until Tomorrow

Don't sleep on these Disney, Star Wars, Batman, and more LEGO deals in the midst of Amazon's Big Spring Sale.

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Mar 30 • 9:21 PM EDT • Technology • ign.com
Best girl Azula gets new gameplay details revealed with two distinct movesets based on her mental state in Avatar Legends

After coming back from being canceled, Avatar Legends: The Fighting Game has quickly risen up the ranks to become one of the most anticipated titles of the genre this year.Following the most recent Avatar character and release date announcements ...

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Mar 30 • 7:06 PM EDT • Technology • eventhubs.com
Stocks making the biggest moves premarket: Sysco, CrowdStrike, Alcoa & more

These are the stocks posting the largest moves premarket.

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Mar 30 • 7:29 AM EDT • Technology • cnbc.com
Scientists solve 40-year-old biological mystery behind sleeping sickness

To survive in the human bloodstream, the African trypanosome parasite wears a "cloak" made of proteins known as a variant surface glycoprotein (VSG). The study, published in Nature Microbiology, identifies ...

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Mar 30 • 5:00 AM EDT • Science • phys.org
Science Central unveils new planetarium

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Mar 29 • 10:50 AM EDT • Science • insideindianabusiness.com
Halo: Campaign Evolved Involves ODSTs, Brutes and New Covenant Faction in Prequel Missions

However, Halo Studios is also reportedly reusing Halo Infinite's models for the Banished Covenant and UNSC Marines in the same.

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Mar 29 • 10:00 AM EDT • Technology • gamingbolt.com
FULL SHOW: Inside INdiana Business 3/29/26

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Mar 29 • 8:00 AM EDT • Business • insideindianabusiness.com
Belgium thrash USA 5-2; Mexico vs Portugal ends 0-0 in football friendlies

A man died after falling from the stands at Azteca Stadium, where Mexico hosted Portugal with Ronaldo missing the match.

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Mar 29 • 3:08 AM EDT • Sports • aljazeera.com
DDR5 RAM prices show rare drop amidst memory shortage after TurboQuant announcement

U.S. buyers are starting to see memory prices level off at major retailers. Amazon shoppers will find that some Corsair Vengeance DDR5 RAM is now slightly more affordable. Google’s TurboQuant algorithm may allow AI data centers to use fewer modules, increasing supply for gamers.

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Mar 28 • 9:13 PM EDT • Technology • notebookcheck.net
Canadian business stalls over US trade deal jitters

STORY: The Canadian manufacturing hub of Windsor is home to thousands of small and specialized part makers and caters primarily to car companies and equipment manufacturers. The city thrives on close integration with Detroit, America's automotive capital, just across the river.That means it's also on the frontline of tariff and trade uncertainty with Canada's largest trading partner. JACKIE RAYMOND: "Even if we don't directly work with the automotive industry, we indirectly do."Jackie Raymond is co-owner of FASTSIGNS, a Canadian company that designs and installs custom business signs and graphics.The company is coming off its toughest year since the pandemic. Orders from its core automotive clients dried up.And while a new project brought some relief, the company says customers are placing smaller orders, demanding longer payment terms, and bargaining harder on prices.:: FileIt all points to uncertainty tied to the United States-Mexico-Canada Agreement, which is up for review this year. It's a deal U.S. President Donald Trump has repeatedly said he could scrap.:: Washington, D.C. / December 2, 2025TRUMP: "...and we'll either let it expire or we'll maybe work out another deal with Mexico and Canada...":: FileThe agreement - known as CUSMA north of the border - exempts most Canadian goods from U.S. levies.While Mexico has started formal negotiations with the U.S. over the deal's renewal, Canada has so far only held informal talks.RAYMOND: "I think the CUSMA is very, very important because it trickles down to every little business right down to your barber shop and your nail shop, which will affect all of our customers."The situation in Windsor reflects a broader unease facing Canada's economy, which contracted 0.6% in the fourth quarter. About 90% of the city's exports cross the border, often multiple times during production.Manufacturing accounts for nearly a quarter of employment in the Windsor-Essex region.Its chamber of commerce, which represents about 750 businesses, says companies paused investments, delayed production, and cut jobs at the height of the tariff uncertainty last year. :: FileWindsor partly regained its footing as Trump exempted USMCA-compliant exports from Canada from tariffs in March last year.But uncertainty still drags on business confidence and Windsor's unemployment level remains one of the highest among major cities in Canada.Local shops complain of lower traffic and restaurants report thinner crowds.And builders say the housing market – often among the first sectors to show strain from the knock-on effects of tariff uncertainties – is near a standstill.Brent Klundert of BK Cornerstone, a local real estate builder, said he laid off 13 of his 21 staff as sales and prices slumped last year. "And you know, when people are going to make the biggest investment of their life, they really want confidence in their job, in the longevity of their job in the economy itself. And people lost that due to the tariffs.” // “If we can get through CUSMA, if we can get through our trade agreements with the US, I think that that will add a lot of confidence into the marketplace that we've been lacking.”Since January Klundert has rehired 10 of his employees, hoping homebuyers would start coming back.So far, only a few have.

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Mar 28 • 7:55 AM EDT • Business • finance.yahoo.com
AMD Stock Slips as Gamers Call for FSR 4 Support on RDNA 3 and RDNA 2 GPUs

AMD stock fell on Friday as gamers call on the company to bring FSR 4 support to older GPUs.

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Mar 27 • 11:55 AM EDT • Technology • tipranks.com
Justice Department secures denaturalization of convicted gun trafficker and health care fraudster

The DOJ announced it secured the denaturalization of two criminals “who obtained U.S. citizenship through fraud" and sued to revoke the citizenship of a third.

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Mar 26 • 9:46 AM EDT • Health • foxnews.com
Orlov Offers Winning Wisdom Amidst Sharks’ Losing Streak (+)

ST. LOUIS — Dmitry Orlov has been an unappreciated leader in the San Jose Sharks’ surprising season. The veteran defenseman is also one of just four Sharks players who have won a Stanley Cup. Orlov hoisted the Cup in 2018 with the Washington Capitals. “It’s not easy. It’s a mind-set,” he said. “If you want […] The post Orlov Offers Winning Wisdom Amidst Sharks’ Losing Streak (+) appeared first on San Jose Hockey Now.

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Mar 26 • 3:27 AM EDT • Sports • sports.yahoo.com
Danish Foreign Minister Becomes Kingmaker After Trump Standoff

Denmark’s headstrong Foreign Minister Lars Lokke Rasmussen holds the keys to deciding who becomes the Nordic nation’s next prime minister.

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Mar 25 • 8:14 AM EDT • Politics • bloomberg.com
Brad Stevens quickly removes himself from consideration in North Carolina's coaching search

Not even one of the three best jobs in college basketball is moving Stevens out of Boston

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Mar 25 • 8:13 AM EDT • Sports • cbssports.com
How this Indiana teacher makes her AP personal finance class click for students

With over two decades of teaching under her belt, Kristin Lidstrom is piloting the AP class for Fishers students. “By the time students are making real financial decisions, they should already feel confident navigating them, not encountering the concepts for the first time,” she said.

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Mar 25 • 7:00 AM EDT • Business • chalkbeat.org
‘Project Hail Mary’ Is Out-of-this-world Entertainment

Back in 2017, filmmakers Phil Lord and Christopher Miller were hired and, several months into filming, fired from the Han Solo prequel movie, “Solo: A Star Wars Story.”

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Mar 25 • 5:29 AM EDT • Entertainment • mountaintimes.info
Entertainment lineup announced for Red River Valley Fair

WEST FARGO (KFGO) - The Red River Valley Fair just announced the 2026 grandstand entertainment lineup, bringin...

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Mar 24 • 12:16 PM EDT • Entertainment • kfgo.com
Titans schedule Top 30 visit with versatile Clemson offensive tackle

The Tennessee Titans are adding another offensive lineman to the Top 30 visit list with Clemson tackle Tristan Leigh.

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Mar 24 • 4:04 AM EDT • Sports • sports.yahoo.com
SP40 Restomod Is Built Around The One Ford That Edsel Actually Got Right

Carbon-bodied SP40 brings the style of Edsel Ford’s one-off speedster to a wider audience

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Mar 23 • 5:22 PM EDT • Technology • carscoops.com
The problem with Trump promoting "gold standard science"

This simplistic branding is confusing, misleading, and potentially harmful to scientific literacy.

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Mar 23 • 7:30 AM EDT • Science • motherjones.com
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At 85, I can still work out on the bars and do headstands with my wife

Peng Lin Hua, 85, says retirement didn't slow him down. He and his wife split their time between two countries.

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Mar 23 • 12:03 AM EDT • Health • businessinsider.com
French Local Elections Are Yardstick for Far Right. Initial Results Are Mixed.

France’s municipal elections ended on Sunday evening. Full results were not expected for hours, but the first projections suggested the far right may not have made major gains.

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Mar 22 • 5:03 PM EDT • Politics • nytimes.com
Your Thymus and Your Healthspan

Our thymus gland plays a central role in the development or our immune system, specifically for supporting T cell development (how these cells got their name, maturation and differentiation in the thymus) and discriminating between self and foreign, non-self antigen proteins with production of dendritic cells. As we age, our thymus gland shrinks—the process known as involution—with progressive change from spongy to fatty tissue, with loss of functionality. But this process, with respect to timeline and extent, markedly varies from one person to the next. And to make things even more complicated, our thymus gland anatomy and precise location in the chest also is highly variable. So the famous Frank Netter diagrams from the 1960s (such as at left below) don’t capture the remarkable heterogeneity that a random set of 12 chest CT scans (below at right). What I consider as 2 landmark papers in Nature this week (here and here) used AI to quantify health of the thymus in 2 large cohorts, and then correlate the metric to a broad array of health outcomes. In this edition of Ground Truths, I’m going to cover three questions: (1) How was thymus health determined by AI?; (2) How is thymus health linked to key clinical outcomes? and (3) Are there ways we can promote a healthy (aka rejuvenate) thymus gland in our later years? Subscribe 1. How was thymus health determined by AI? This was accomplished by extensive work developing and validating an AI pipeline for 2 stages, the first for localization and segmentation of the thymus bed, and the second to quantify a digital marker, termed the thymic health score. There’s a lot to this algorithmic development, so I won’t go into all the details, but just provide a rudimentary outline of what was done. The 1st stage used supervised learning with 2 radiologists reviewing 2,461 chest CT scans. That work trained a 3D U-Net model to automatically identify the thymic bed’s 3D cropped region using center of mass coordinates, which reached 99.8% accuracy. The 2nd stage used a foundation model that was pre-trained with SwAV (which stands for Swapping Assignment between multiple Views), a self-supervised model, that generated a high-dimensional thymus representation of 4,096 features. That compares to the radiology reductionist and subjective scoring of 0 to 3 where 0 means the thymus is fully degenerated and fatty, and 3 is considered dense, intact glandular soft tissue. Notably, the self-supervised learning (SSL) performance was superior to supervised (AUC ~0.75 vs 0.55, respectively) reflecting the shallowness of the 0-3 classifier vs SSL’s holistic, self-taught AI. The thymic health score ranged from 0 to 100, with the highest number indexed to fully preserved thymic health. The algorithmic work extended to explainability with both Shapely value distribution, meaning the model was holistic not relying on any “magic” pixel, and occlusion sensitivity, demonstrating the model’s performance was not affected by ribs, sternum, lung tissue, but rather focused on the thymic bed directly. Below are a few saliency maps from the occlusion sensitivity that indicate the thymic bed focus, not affected by neighboring structures, using the jet color scale. Now the AI was ready for processing ~25,000 CT scans, each over 30 MB files, from the 2 large participant cohorts to provide a thymic health score, it did so in less than 14 hours, which is less than 2 seconds per scan! Share 2. How is thymus health linked to key clinical outcomes? The two cohorts were the National Lung Screening Trial, NLST (N=25,031) and the Framingham Heart Study, FHS (N=2,581) each with baseline demographics and long term follow up of >12 years for health outcomes. From the NSLT, you can see below that increased age and body-mass index were correlated to reduced thymic health. And, overall, men had reduced thymic health scores compared with women. There are a lot of graphs in the paper for outcomes, for both the NLST and FHS cohorts. To simplify the major outcomes, below is a composite Figure with striking reduction of all-cause mortality and for the different causes of death. The results were consistent between the 2 cohorts. For example, the cardiovascular mortality hazard ratio average was 0.57 in NLST and 0.38 in FHS (weighted to be 0.53 for the aggregate). The reduction of mortality also extended to digestive diseases and pulmonary disease (data not shown below). Lung cancer incidence was reduced by 36% for high vs low thymic health (Figure below, with a panel -incidence and b panel-mortality, adjusted for age, sex, BMI, smoking status). Notably, there was a smoker’s paradox: lower incidence and improved survival for lung cancer in smokers who had a high thymus health score. Smoking was associated with lower thymic scores whereas alcohol was not. Higher thymic health was linked to higher HDL cholesterol, lower triglycerides, lower fasting blood glucose, and lower systolic and diastolic blood pressure. Inflammation biomarkers, such as C-reactive protein and interleukin-6, were elevated in the people with lower thymic health scores. In their second paper, the same team looked at the relationship between thymic score and outcomes for 3,476 patients receiving cancer immunotherapy. The non-small cell lung cancer progression-free survival was reduced in patients with low thymic health score. A parallel relationship for survival was seen for other types of cancer including melanoma, breast, and kidney with a 44% lower risk among high thymic scores (Figure). A similar pattern was seen with different immune checkpoint inhibitors. The thymus health score outperformed programmed death ligand-1 (PD-L1)and tumor mutation burden (TMB) assay of the tumor and was an independent prognostic marker of progression-free survival. In this dataset, a direct connect with thymus score and adaptive immune function was noted with a correlation before cancer treatment for both T-cell diversity and thymus T-cell production (a metric known as T cell receptor excision circles). Thymus Removal Study There is a highly relevant citation about thymus function before moving onto ways to rejuvenate it. In 2023, a very important study of thymus removal during cardiothoracic surgery was published, with 1146 patients undergoing thymus removal vs 1146 matched controls (mean age 55 years). The adverse outcomes for thymus removal were striking, with a 2.9 higher risk of all-cause mortality and doubling of cancer incidence, 1.5 fold increase in cancer mortality, and 1.5-fold increase in autoimmune diseases. The immune function showed marked compromise after thymus removal, as reflected by CD4+ and CD8+ T cells (Figure below) Share Ground Truths 3. Are there ways we can promote a healthy (aka rejuvenate) thymus gland in our later years? In recent months we’ve learned a lot about the process of thymus involution and the pathways by which this may be modulated. Thymus involution is primarily due to loss to thymus epithelial cells (TECs) and there are 2 subtypes with different functions: the cortical, responsible for positive selection of T cells, and the medullary, for negative selection. When adipose tissue infiltrates the thymus, thymic adipocytes are pro-inflammatory, knocking out T-cell output. Likewise, systemic inflammation, or “inflammaging,” from smoking, obesity, and chronic stress promote thymic adipocytes. Now, from preclinical studies, we know about key pathways that account for these processes. Historically, back in 2014, FOXN1 was recognized as a single master transcription factor essential for TEC function, with studies in mice with forced FOXN1 upregulation leading to thymus regeneration. That laid the foundation for potential regrowth of quiescent thymus cells. It took awhile to find pathways to accomplish this goal and to even refute its role as the master regulator. The Liver-Thymus Axis Feng Zhang and his team recently showed that injection of an mRNA vaccine to the liver encoding DLL1, IL-7 and FLT3-L in combination, factors known to support thymopoiesis (Figure), successfully enhanced immune function in aged mice. However, the effect was transient. The FGF21 Story Two reports in 2025 addressed the thymus gland’s production of FGF21, a growth factor (fibroblast growth factor 21) and its control of thymus involution. This growth factor is also produced by the liver, but it doesn’t have impact on the thymus in aged rodent models. In contrast, The liver’s hepatocyte growth factor (HGF) has been shown to reverse senescent TEC structural changes. Growth hormone stimulates production of insulin growth factor-1 (IGF-1) in the liver and the thymus. Two small studies in human participants (TRIIM, for Thymus Regeneration, Immunorestoration, and Insulin Mitigation) of 6 and 50 people, respectively, treated with combined human growth hormone, metformin and DHEA, suggested the potential of slowing epigenetic aging and improving thymus mass and function. But the combination of drugs, small sample, and lack of controls make conclusions murky. Increased thymus FGF21 led to increased CD8 T cells in old mice and extended healthspan and improved physical performance. Building on the previous FOXN1 data, ablation of β-klotho, the obligatory co-receptor for FOXN1, accelerated thymic aging. The benefit to FGF21 was confirmed in a companion paper using an FGF21 knock-in mouse model showing thymus enlargement and increased TECs throughout the lifespan. (schematic Figure below). The accompanying editorial for these 2 papers speculated: “The proposed link between age-associated thymus involution and organismal aging is intriguing, and suggests we might seek to achieve systemic rejuvenation by counteracting thymic involution.” Other Factors Lessons from the Axolotl (Mexican Salamander) In an elegant set of experiments of the axolotl (Figure), known for its complete thymus regeneration after total surgical removal, mediators were identified. Surprisingly FOXN1 was dispensable. But midkine, a growth factor, appeared to be the driver, the initiator of thymus cell growth, survival, and repair. Other components that contributed were Postn+ (periostin-expressing mesenchymal niches) and Ccl19, a chemokine protein from the bloodstream. RANK and RANKL RANK (receptor activator of nuclear factor κB its ligand (RANKL) have been considered key regulators of medullary TECs. In a study of both aged mice and human thymus cell cultures, their key role was confirmed, with multiple benefits of resorting TEC function, recruitment of progenitor cells, and T cell development. Subscribe Summing Up This body of work strongly supports the health of the thymus gland as a critical regulator of human healthspan, not just a correlate or link. The new landmark studies are reinforced by the regenerative biology experimental models that have shown, via an array of mediators, that healthspan of aged mice is at least in part dependent on thymus gland function and its critical role for maintaining adaptive immunity. It sure seems that we’d be better off having an immune reservoir of naive T cells instead of a profile in older adults of exhausted, low quality, memory T cells, with a senescent phenotype. It is striking that we ignored the importance of the thymus gland for many decades. A wake-up call was the results of the thymectomy matched control study reviewed here, with the opposite of high thymic health score improved health outcomes. The convergence of AI and healthspan here is notable. The exceptional and laborious work for developing and validating (no less explaining) the AI to quantify thymus health set the foundation for probing the connect the major health outcomes in two cohorts with extensive follow-up. We’ve never had a way to meaningfully quantify the thymus gland before, so this represents important leverage of supervised, self-supervised, and transformer models. The study wouldn’t have been possible without AI. And it begs the question as to whether there are ways we can maintain our thymus at a high health score. But it’s not so simple to rejuvenate our thymus. There are multiple risks including the induction of autoimmunity, increasing the risk of cancer, and inducing a pro-inflammatory state. For example, factors that increase TEC proliferation could compromise the medulllary negative selection process and leak out auto-reactive (self-attacking) T cells. Thymic cells could be induced to proliferate, but we know, for example, that growth hormone and IGF-1 are associated with an increase risk of cancer. If thymus rejuvenation doesn’t clear out the accumulated senescent cells in older adults, then inflammation within the gland could block the production of TECs. Keeping these risks in mind, we now have identified many ways to keep our thymus healthy as we age that undoubtedly will be tested in clinical trials going forward. Ultimately, the benefit-to-risk tradeoffs will be defined. In the meantime, we have desperately needed an immunome. As I’ve stressed in multiple prior Ground Truths, we have no test in the clinic to assess a patient’s immune status! It was very encouraging for me to get an email from Hugo Aerts, the senior author of the landmark papers in the days after they were published: “I also wanted to say that your Substack on “Why We Need an Immunome” was inspiring for this work. We found it a very compelling perspective and greatly enjoyed reading it.” Just having an assessment of a person’s immune status via a chest CT scan, with millions of these performed per year, might help in guiding the right immunotherapy for cancer (e.g. more intensive, combinations for those with low thymic health scores) and help define people who are increased risk for age-related diseases of cancer, cardiovascular, and neurodegenerative. The main theme of Super Agers is that we now have many layers of data (genetics, proteins, biomarkers, organ clocks that can be integrated via multimodal AI) for us to define a person’s specific risk decades before one of these age-related diseases leads to symptoms, enabling prevention. From the new studies this week, we can add thymus health score as yet another way to understand a person’s risk, a window into their adaptive immune system and healthspan. And perhaps someday we will be able to safely rejuvenate the thymus, or maintain its health through one’s life, and use the thymus health score to monitor. NB: I wrote this post (No A.I.) A Quick Poll Loading... ********************************************************************* Thanks to Ground Truths subscribers (now > 200,000) from every US state and 212 countries. Your subscription to these free essays and podcasts makes my work in putting them together worthwhile. Please join! If you found this interesting PLEASE share it! Share Ground Truths Paid subscriptions are voluntary and all proceeds from them go to support Scripps Research. They do allow for posting comments and questions, which I do my best to respond to. Please don’t hesitate to post comments and give me feedback. Let me know topics that you would like to see covered. Leave a comment Many thanks to those who have contributed—they have greatly helped fund our summer internship programs for the past two years. It enabled us to accept and support 47 summer interns in 2025! We aim to accept even more of the several thousand who will apply for summer 2026.

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Mar 22 • 2:18 PM EDT • Health • erictopol.substack.com
VoidStealer malware steals Chrome master key via debugger trick

An information stealer called VoidStealer uses a new approach to bypass Chrome's Application-Bound Encryption (ABE) and extract the master key for decrypting sensitive data stored in the browser.

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Mar 22 • 10:32 AM EDT • Technology • bleepingcomputer.com
Businesses worried as fuel prices rise

An increase in fuel prices amidst the US-Israel war with Iran is affecting businesses in the UK.

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Mar 22 • 3:28 AM EDT • Business • yahoo.com
Bloodstained: The Scarlet Engagement listed for Nintendo Switch, plus an unannounced 505 Games Switch 2 title

Bloodstained: The Scarlet Engagement has been listed for Nintendo Switch alongside an unannounced Switch 2 title from 505 Games. The Scarlet Engagement, a sequel to the original, was previously announced last year. Although there wasn’t any news about a Nintendo release, the latest discovery suggests that we’ll be getting it on Switch at the very least. It’d be somewhat surprising...

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Mar 22 • 12:00 AM EDT • Technology • nintendoeverything.com
Kings fall 4-1 to Sabres amidst playoff push

The Los Angeles Kings fall short to the Buffalo Sabres in a 4-1 loss Saturday at Crypto.com Arena. Artemi Panarin would score the Kings' lonesome goal, but it was no match for Buffalo's four goals by four different skaters. The Kings stand in the third place Wild Card spot at 28-25-16 and 72 points.

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Mar 21 • 8:25 PM EDT • Sports • sports.yahoo.com
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Why cats always land on their feet, according to science

Why do cats always land on their feet? It’s one of science’s most enduring mysteries in the realm of pets.

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Mar 20 • 3:23 PM EDT • Science • yahoo.com
Bears stadium debate: New Soldier Field proposal includes dome, entertainment district

As the Chicago Bears weigh potential moves to Arlington Heights or Northwest Indiana, a new proposal is pitching a different future — keeping the team at Soldier Field with a major overhaul of the historic stadium.

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Mar 19 • 4:06 PM EDT • Entertainment • fox32chicago.com
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Deadline Hollywood

Debra OConnell, Chairman of Disney Entertainment Television, has unveiled her direct reports, including Craig Erwich, who adds 20th TV Oversight. Read more below.

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Mar 17 • 12:00 AM EDT • Entertainment • facebook.com
Deadline Hollywood

CBS and Entertainment Tonight are saying goodbye to The Neighborhood with a farewell special. Read more below.

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Mar 16 • 6:05 PM EDT • Entertainment • facebook.com
Why Loadstar’s Brian Haymon chose the riskier path

When Brian Haymon created his own grassroots, from-the-ground-up company at the age of 57, he didn’t want it to be just another 2.0 version of the business he’d just left. He wanted to tap into one of the main advantages afforded to a new entrepreneur: a chance to create a resilient, malleable business model not […]

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Mar 16 • 3:32 PM EDT • Business • businessreport.com
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The New York Times

Gun-rights activists are a long-established force in Republican politics. But no candidate with a credible chance of reaching Congress has had a profile quite like Brandon Herrera, who has built a...

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Mar 16 • 7:00 AM EDT • Politics • facebook.com
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Trump Rejects Deal With Iran on Current Terms as War Rages On

President Donald Trump said Iran is ready to make a deal to end the war but the US wants better terms, signaling no let up in a conflict that’s brought shipping in the strategic Strait of Hormuz to a near standstill and upended energy markets.

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Mar 15 • 4:02 AM EDT • Politics • bloomberg.com
These WI Rapids businesses & churches closed March 15 due to snowstorm

Here's a list of businesses and churches in the Wisconsin Rapids area that have announced closures for March 15 because of the forecasted snowstorm.

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Mar 14 • 2:00 PM EDT • Business • wisconsinrapidstribune.com
Florida Is Trying to Ignore Measles Until It Can’t

The state is in the midst of an outbreak, but its health department has been mostly silent.

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Mar 13 • 7:00 AM EDT • Health • theatlantic.com
UofL announces permanent closure of Gheens Science Hall & Rauch Planetarium amidst economic challenges

The University of Louisville announced that the Gheens Science Hall & Planetarium will be permanently closed due to financial challenges.

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Mar 12 • 5:40 PM EDT • Science • wave3.com
WellSpan Health opens new Midstate hospital

(WHTM) — Wellspan Health opened its second Midstate hospital in as many days. The ribbon was cut Wednesday at WellSpan Shrewsbury Hospital. The area needs more health care, since, for many in south…

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Mar 11 • 4:46 PM EDT • Health • abc27.com
Viking Sports Weekly {March 11}

This Week's Events

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Mar 11 • 6:23 AM EDT • Sports • csuvikings.com
Grand Prix Arlington set to bring top speeds to entertainment dstrict
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Mar 8 • 11:20 PM EDT • Entertainment • cbsnews.com
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Pasadena Now

1,000 Students Head to Shrine Expo Hall for 76th LA County Science Fair Approximately 1,000 middle and high school students from across Los Angeles County will present research projects at the 76th...

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Mar 8 • 9:50 AM EDT • Science • facebook.com
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Former State Sen. Brett Lindstrom, who said he was leaving politics, abandons Republican label

Lindstrom, until late January, was running for the GOP U.S. House nomination in NE-02 and was rumored to weigh bid for governor.

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Mar 7 • 6:15 AM EST • Politics • nebraskaexaminer.com
SCSU’s online computer science program named one of nation’s best

SCSU's program has been ranked No. 17 in the United States by TechGuide's rankings.

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Mar 6 • 10:59 AM EST • Science • today.stcloudstate.edu
Grandstand entertainment announced for Wisconsin Valley Fair

Organizers with the Wisconsin Valley Fair announced it’s grandstand entertainment for 2026.

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Mar 6 • 8:00 AM EST • Entertainment • wsaw.com
Boston 25 News

Ahead of the 2026 World Cup, the Kraft Sports and Entertainment Group will help cover the town of Foxborough’s “security-related costs.”

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Mar 5 • 10:45 PM EST • Entertainment • facebook.com
Heavy police presence in Woodstock as officers respond to incident at business

JUST IN

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Mar 5 • 1:16 PM EST • Business • wsbtv.com
Earth’s Geological Record Is Missing 1 Billion Years. Scientists May Have Just Found Where They Went.

There's a billion-year gap in Earth's geological history. A new study seeks to explain the mystery.

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Mar 5 • 8:00 AM EST • Science • popularmechanics.com
UNC football announces 2026 home game designations

North Carolina announced its special home game designations for the 2026 season, including Family Football Day and Senior Day.

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Mar 4 • 8:02 PM EST • Sports • sports.yahoo.com
Washington Capitals to Host Hockey Talks in Partnership with MedStar Health on March 9

MSE Foundation to Present Shoulder Check with $10,000 Donation During March 9 Game

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Mar 4 • 9:55 AM EST • Health • nhl.com
How the IRC supports women’s health amidst crisis in remote regions of the DRC

In times of conflict, women and girls face the greatest risks—violence, exploitation and limited access to essential care. This International Women’s Day, discover how the International Rescue Committee (IRC) is supporting survivors of gender-based violence in the Democratic Republic of Congo (DRC).

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Mar 3 • 7:00 AM EST • Health • rescue.org
John Kimmel Steps Away from Training to Focus on Bloodstock Business

John Kimmel has announced his retirement from training on the New York circuit to focus on building his bloodstock buisness.

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Mar 2 • 3:24 PM EST • Business • thoroughbreddailynews.com
US-Iran conflict brings Amazon's Abu Dhabi operations to a standstill

The e-commerce giant spent years building a logistics footprint in the Middle East. Some of those operations are on hold now.

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Mar 2 • 2:39 PM EST • Business • businessinsider.com
Senny Mayulu – PSG: tensions surrounding contract extension

Premier League clubs on alertSenny Mayulu – PSG: tensions surrounding contract extensionThe Senny Mayulu situation is at a standstill at Paris Saint-Germain. Under contract until 2027, the 19-year-o...

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Mar 1 • 2:55 AM EST • Sports • sports.yahoo.com
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#LockerStrong | Craig Laughlin's Heart Health Journey

In honor of Heart Health Month, Craig Laughlin sat down with his ‪MedStar Health‬ cardiac surgeon to talk about his heart health journey and the importance of knowing your heart risk.

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Feb 25 • 7:53 PM EST • Health • nhl.com
25th Navajo Nation Council

Delegate Johnson applauds Navajo Pine students’ innovation at science fair NAVAJO, N.M. –Council Delegate Casey Allen Johnson recently demonstrated his support for science, technology, engineering,...

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Feb 25 • 6:51 PM EST • Science • facebook.com