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Romanian lawmakers back government led by independent Luca Niculescu as country seeks to end monthslong political crisis
Romanian lawmakers back government led by independent Luca Niculescu as country seeks to end monthslong political crisis.
MCG and Itiliti Health Form Partnership to Support Health Plans with CMS-0057-F Compliance
/PRNewswire/ -- MCG Health, part of the Hearst Health network and the industry's source of truth for trusted clinical guidance, today announced a strategic...
AP Business Students
Westhampton Beach High School students spoke about their experience in the new AP Business with Personal Finance course.
Mississippi Gulf Coast Community College students use AI to solve business problems
Students at the Harrison County campus are learning ways to solve real-world problems using artificial intelligence.
Bush family royalty backs Democrat in battle to flip Texas blue
Barbara Bush donated $2,500 to a PAC supporting James Talarico's Texas Senate race against Ken Paxton, using her real name in public FEC filings.
Houston voters welcome long lines as early voting begins
For some voters, participating in the election also meant encouraging others to do the same.
UW-River Falls to offer Halloween carnival and 'Haunted Lab' science demonstrations Oct. 20
Two special Halloween-themed events are planned at the University of Wisconsin-River Falls on Tuesday, Oct. 20, including a Halloween carnival and “Haunted Labs” science demonstrations.
Christina Applegate Says She Was Misdiagnosed With MS After Yearslong Battle
Years after Christina Applegate shared that she was battling multiple sclerosis, the actress said she is "back at square one" after learning she had been misdiagnosed.
Christina Applegate Tearfully Shares She Was Misdiagnosed With MS: ‘Back at Square One’
The actor shared the stunning news that five years after she was given a diagnosis of multiple sclerosis, her doctor told her she does not have the disease.
US inequality is getting worse in ways you might not expect
From tax policy to gas prices and tariffs, a mix of new factors is making inequality in the US more extreme.
Griffin Gaming Partners and Entertainment 360 launch new company to support video game adaptations for film and TV
HITpoint Entertainment will "combine Griffin's relationships with devs and publishers with Entertainment 360's producing track record on IP-driven franchises"
Wii Sports is back on the Switch 2, and it rules
Nintendo Switch Sports Resort is quietly one of the console’s most important games.
Final Fantasy dips back into the SNES golden era with Resonance
Final Fantasy in glorious HD-2D.
Antigravity just halved the price of its drone — by swapping its headset for wristwatch control
$800 now buys you a follow-me drone instead of an FPV flight experience.
Seattle Art Museum renovations: Peek inside at construction
An $8.1 million project is underway at Seattle’s flagship art museum, adding more public spaces to gather, work and dine at the museum. Take a peek!
Aprio Broadens its AI-Powered Advisory Partnership with Intuit to Further Accelerate Mid-Market Business Growth
/PRNewswire/ -- Aprio, the 20th largest business advisory and accounting firm in the U.S. today announced the next phase of a strategic partnership with...
Christin Applegate reveals doctors misdiagnosed her with multiple sclerosis 5 years ago
Christina Applegate revealed she was misdiagnosed with multiple sclerosis, breaking down in tears as she explained that “something else is going on” after doctors said she actually didn’t have MS.
People who've finished Call of Duty: Modern Warfare 4 on the new YOLO, single-life difficulty share experiences and tips for doing so
In COD: Modern Warfare 4's new YOLO difficulty, any game over screen takes you back to the very beginning of the game. But there are some tips for beating it.
'Office Space' star Richard Riehle dies at 78
Actor Richard Riehle arrives at the premiere of New Line Cinema's 'A Very Harold & Kumar 3D Christmas' at Grauman's Chinese Theatre on November 2, 2011 in Hollywood, California. (Jason Merritt/Getty Images)Richard Riehle, known for his role in the 1999 film Office Space, has died. He was 78.A statement shared by Artists & Representatives and Wright Entertainment, Inc. announced Riehle's passing on Monday, writing, "Our industry has lost an exceptional talent, and our community has lost a truly wonderful man.""We are deeply saddened to confirm the passing of our beloved client, Richard Riehle, this past weekend," the statement said. "A remarkable actor whose career in theater, film, and television spanned nearly five decades and more than 400 projects, Richard leaves behind an extraordinary legacy."The statement continued, "Beyond his immense talent, he will be remembered for his genuine goodness, boundless kindness, and unwavering generosity, particularly toward emerging actors and filmmakers, whom he encouraged and supported at every opportunity."Born on May 12, 1948, Riehle starred in many television series and films over the years.Notable projects include Casino, The Man from Earth and Deuce Bigalow: Male Gigolo.He got his start as an actor at the University of Notre Dame, where he was involved in the University Theatre and starred in several stage productions. He went on to earn a Master of Fine Arts in acting and directing from the University of Minnesota.While he's played characters that have an "average Joe" presence, he always made the most of his brief screen time.Some roles that he is remembered for include The Quartermaster in Glory, the train guard in The Fugitive, Reverend Scroggins in Fried Green Tomatoes and Bill Cozbi in Bridesmaids.On television, he starred as Principal Ed Rooney in the 1990 series Ferris Bueller and as grandfather Walt Finnerty in the early 2000s sitcom, Grounded For Life.In 2023, he also played Warden Reynolds in Barry.Riehle is survived by his wife, Jane Latham, and their four children.Copyright © 2026, ABC Audio. All rights reserved.
How voters feel about trans rights and abortion access will soon be put to the test
How do voters feel about trans students participating in school sports teams? Or abortion access? The U.S. is about to find out.
Romania Politics Government
Romanian Prime Minister designate Luca Niculescu attends a joint parliament session called to give a vote of confidence for the new government team, in Bucharest, Romania, Tuesday, Oct. 20, 2026.
JMU Military Science program prepares future military leaders
JMU’s Army ROTC program combines rigorous training, hands-on leadership development, and strong alumni support to prepare cadets for success as future military officers.
Romania Politics Government
Romanian Prime Minister designate Luca Niculescu, left, talks to the Interior Minister designate, Marian Neacsu during a joint parliament session called to give a vote of confidence for the new
Man shot in front of southwest Houston bar after dispute over business ownership
A man is in critical condition after being shot in southwest Houston outside Costa Lounge VIP bar during a dispute, police report.
New Book Includes Previously Unreleased Interviews By Edward Gorey
For ardent Edward Gorey fans there’s a new book available, “Memento Gorey: The Last Interviews with Edward Gorey” by Chatham filmmaker and documentarian Christopher Seufert, published by Schiffer Publishing with
Could AI Use a Simple Photo of Your Face to Reveal Clues About Your Health?
A new AI model can estimate biological age and predict cancer survival outcomes using a simple photo of a patient’s face, though more research is needed before doctors will be able to use it to help them decide on treatments.
‘SIX’ Provides Lively History Lesson
Anyone who has seen “Hamilton” has doubtless thought, “Why can’t we learn all of our history from theater performances?”
Maxwell Economist John Cawley Elected to Prestigious National Academy of Medicine
Membership in the National Academy of Medicine is one of the highest and most esteemed honors in the fields of health, medicine and medical science.
Alexa Tablet 12 Pro Review: Amazon Comes Out Swinging At The iPad
Amazon's Alexa Tablet 12 Pro is an entirely different beast than the Fire tablet lineup, and its more premium build and specs make it a legit iPad competitor.
Too Lost’s latest expansion is a deal with Xelon Entertainment
Distributor and tech firm Too Lost's ambitions in the APAC region continue. It acquired Australian distributor and artist-services company Gyro·Group in July, and now it has announced a partnership with another distributor, Xelon Entertainment.
12 rising actors you didn’t know have famous parents
Having famous parents doesn’t necessarily get you the role — but it does get you in the room. Read about 12 nepo babies on the rise, including who their parents are and where you recognize them from.
Digital Science and Sunmedia Partner to Bring Research Impact Reporting to Japan's Medical Affairs Teams
Digital Science today announced a partnership with Sunmedia to help medical affairs teams across Japan understand the impact of their research.
KFF Tracking Poll on Health Information and Trust: Fall 2026 Update on Vaccine Views
The latest KFF Tracking Poll on Health Information and Trust finds about half of parents mistakenly believe spacing out vaccines is healthier for children, while confidence in many long-standing childhood vaccines is high across partisans. These findings take on new relevance following President Trump's recent executive order calling for changes in U.S. childhood vaccine recommendations, including splitting the measles, mumps, and rubella (MMR) vaccine—currently given as a single combined shot—into three separate vaccines across multiple visits.
Bill Clinton and David Jolly to hold campaign event in Hollywood
They will hold the campaign event at 6:30 p.m. on Tuesday.
Dodgers notes: Shohei Ohtani and what might’ve been
As the baseball world prepares itself for a low-cost World Series, Dodgers fans might still be looking backwards at what might’ve been. Sonja Chen on MLB.com focuses on how the team managed Shohei Ohtani’s injuries, and what perhaps they might’ve done differently. “I haven’t been able to really come to grip in terms of what […]
Hanan Al Kuwari: Executive, Minister, Diplomat - And A Middle-Power Mediator?
The State of Qatar has nominated former minister of public health Dr Hanan Mohamed Al Kuwari for Director-General of the World Health Organization (WHO). Entering a competitive contest alongside six other candidates as the WHO faces financial instability, workforce restructuring, and geopolitical fragmentation, her campaign positions her as a pragmatic, delivery-focused nominee.
Dejan Kulusevski shares heartbreaking admission after making ‘impossible’ injury comeback
Surgery on his right patella in May last year was followed by multiple setbacks
Christina Applegate reveals MS misdiagnosis in shocking health update: 'I lost everything'
Planning TB prevention: Considerations for an evolving toolkit
Explore our TB prevention toolkit: today’s tools, the pipeline of new options, and the open questions ahead.
AI is Changing Science: Here’s What Journalists Need to Know
Researchers are rapidly adopting AI for everything from data analysis to planning and executing entire research studies. Journalists will need to keep up. That means learning the basic principles, strengths, and weaknesses of the diverse technologies labeled as “AI”—and how to tell when using AI in science is actually noteworthy. Luckily for science reporters, knowing your beat well can help you cut through the hype.
Spotify launches paid podcast memberships with perks beyond bonus content
Spotify's new paid memberships let podcasters offer fans exclusive perks, including ad-free listening, early access, and bonus content, while keeping 90% of the revenue.
Rob Reiner almost helped Larry David with his unproduced screenplay but made this movie instead
The comedians had a decades-long friendship, which also helped Cheryl Hines lock in an Emmy-nominated role.
Biotech firm Colossal set to return extinct bird’s egg to New Zealand
The biotech firm trying to bring extinct species back to life, Colossal Biosciences Inc., will return an egg from the flightless moa to its native New Zealand.
No. 1 Exercise To Boost Bone Density, According to a Doctor
In TODAY.com’s Expert Tip of the Day, a doctor shares his favorite compound exercise to boost bone density and protect against bone loss in midlife.
Tecsys delivers AI capabilities to help health systems anticipate and act on pharmacy and supply chain risks
/PRNewswire/ -- Tecsys Inc. (TSX: TCS), an industry-leading supply chain management company, today announced the availability of AI solutions that help health...
Bickerstaff’s Pistons Open Against a Reshaped Boston Celtics
Detroit tips off the NBA season Tuesday against a Boston team that remade itself this summer. #Pistons
AI agents are joining the workforce, so it’s time to rethink the business plan
Once agents take over the grunt work, ask what your team could finally tackle, because adopting AI alone won’t set you apart from competitors.
Christina Applegate Reveals She Was Misdiagnosed With MS: ‘I’m Back at Square One’ and It’s a ‘Mindf—’
Christina Applegate returned to her podcast, “MeSsy,” on Tuesday with some shocking news: She was misdiagnosed with multiple sclerosis. After taking a break from the podcast for seven months due to he...
'DWTS' Dedication Night: What each couple will dance to Tuesday night
Dancing with the Stars returns Tuesday night, with the 10 remaining couples participating in the always emotional Dedication Night. The evening allows the celebrity dancers to perform for someone or something important to them, often featuring guest appearances.
Romania Politics Government
Romanian Prime Minister designate Luca Niculescu arrives for a joint parliament session called to give a vote of confidence for the new government team, in Bucharest, Romania, Tuesday, Oct. 20,
NC State a touchdown favorite at Stanford
NC State is making its first trip to Stanford since the Cardinal joined the ACC, which is to say that we’re in for a very late night of who-knows-what. Should be fun. The Wolfpack is a seven-point favorite to win this one, and if there’s any sort of turnaround on the horizon for this group, […]
The Broad to move works to Paris and Leimert Park during construction
The Broad will display more than 160 works in a major exhibition at the Fondation Louis Vuitton in Paris during its final phase of construction. It will also partner with Art + Practice in Leimert Park.
Shipping dates for the iPhone Duo have been pulled forward for many users
Shipping estimates for the Duo are showing as January 22, but some people who pre-ordered have seen the initial date be pulled forward by weeks or even months.
Ten Hag opens up on Ronaldo fallout at Man Utd
Erik Ten Hag has opened up about his fractured relationship with Cristiano Ronaldo during his time at Manchester United, claiming the Portuguese forward was not prepared to meet the physical demands o...
GTA 6 is so detailed no single Rockstar employee has seen it all - which is exactly how we got shrinking horse testicles in Red Dead Redemption 2
The infamous Red Dead Redemption 2 horse testicles were an unplanned feature because Rockstar staff apparently work autonomously, which bodes well for GTA 6.
iPhone Duo orders limited to two per customer as Apple tackles scalping
Apple is limiting iPhone Duo orders to a maximum of two per customer in the US, UK, and elsewhere after...
Nashville CARES sues TN Health over HIV care restrictions
A Middle Tennessee HIV care center is suing the Tennessee Department of Health over new rules that require proof of citizenship to access services.
Foldables are about to get huge
iPhone Duo demand meets a long delivery queue, giving Samsung's Galaxy Z Fold 8 an opening. Plus the latest Google and Android news.
David Arquette brings ‘Scream’ milestone to Cedar Rapids
Wes Craven was almost fired, the first kiss wasn't easy, and “Scream 8” is on the way. David Arquette looks back on 30 years of Ghostface before his Oct. 25 Q&A at the Paramount Theatre in Cedar Rapids.
Pet costume parade coming soon to NewBo City Market
Howl-O-Ween Pet Costume Parade coming to NewBo City Market on Oct. 24. Also, “Candles & Classics” at Orchestra Iowa, Cedar Rapids museum hosts artists market, Iowa City chorus honored, and Clermont concert highlights historic pipe organ.
Brightstar Capital Partners Invests in Material Handling Group, a Technician-Led Provider of Material Handling Equipment and Aftermarket Services
CANTON, Mich. & NEW YORK, October 20, 2026--Brightstar Capital Partners ("Brightstar"), a private equity firm focused on partnering with founders, entrepreneurs, and management teams, has acquired a majority interest in Material Handling Group USA ("MHG" or the "Company"). Financial terms were not disclosed. MHG is a technician-led provider of new, used, and rental material handling equipment and aftermarket parts and service, serving customers across Michigan, New York, and the Mid-Atlantic reg
ChartHop expands organizational intelligence beyond HR data, connecting the business to the people who run it
New Salesforce, Zendesk and Google Sheets connections, finance-facing planning, portfolio-wide headcount visibility and
A week of disgraces dominates state politics
In a recent segment of Colorado Inside Out, Eric Sondermann highlights multiple current outrages in the state and beyond.
Knicks’ OG Anunoby Drops Unexpected Photo Featuring Anne Hathaway
For Knicks fans, this week feels like Christmas came early.After 53 years of waiting, the championship banner finally goes up at Madison Square Garden, and the players get their rings in front of a crowd that has earned it.The players have spent the last few days at practice, getting ready for LeBron James and the […] The post Knicks’ OG Anunoby Drops Unexpected Photo Featuring Anne Hathaway appeared first on HEAVY.
Revolut and other banking apps go down as Google Cloud suffers outage
Google Cloud is experiencing service disruptions in London, along with multiple banking apps including Revolut.
A note to readers: Science, accountability and elections
Dear readers, As early voting begins, I wanted to share some news — and why it connects to the decisions we make at the ballot box. I’ve been selected for the inaugural cohort of the South Atlantic Climate Journalism Hub mentorship program, hosted by Covering Climate Now. I’m excited to join this group, learn from scientists and fellow journalists, and expand my science reporting. Science directly ties to governance. Local officials make decisions about where development goes, how infrastructure is maintained, what emergency preparations receive funding, and how communities rebuild after disasters. Understanding the evidence behind those decisions helps us evaluate whether our government is serving us well. Here in western North Carolina, those connections are all around us, in Lake Lure and beyond. Flood maps inform decisions about property and development. Engineering assessments help identify risks at dams and bridges. Rainfall forecasts guide emergency preparations. Geological information helps explain landslide hazards. Water testing gives communities information they need to assess conditions. Meteorologists’ knowledge and public perception of weather events shape public safety. Each involves scientific or technical knowledge. Each also raises questions about public responsibility: What did officials know? How did they use that information? What did they tell the public? What did taxpayers receive for their money? A study can identify a problem. Elected officials still have to decide what to do about it, how to pay for it, and how to explain their choices. Reporting should examine both the evidence and the response. That is where I want to strengthen my work. My reporting on Helene recovery, infrastructure, flooding, public safety, and public spending has repeatedly brought me to questions that require scientific expertise alongside public records. This mentorship may help me better understand the research, ask more precise questions, and explain the answers clearly. I also bring the perspective of someone living with these concerns. I live downstream of Lake Lure Dam, and landslides affected my property during Helene. Those experiences bring urgency to my questions. Careful reporting helps establish the answers. Readers deserve to know what the evidence shows, where uncertainty remains, and whether officials accurately describe the information guiding their decisions. You also deserve scrutiny of proposed solutions: what they cost, what they are expected to accomplish, and what risks remain. Access to that information matters. As a mostly deaf journalist who relies on written communication, I will continue pressing for written public warnings, records, and explanations that people can read and use in real time. As you consider the candidates seeking your vote, consider how they approach evidence, preparedness, and transparency. Do they support local journalism, even when it’s not parroting a press release? Do they explain weather events clearly in plain English and explain their decisions after them? Make supporting records available? Acknowledge uncertainty? Follow through when a report identifies a risk? Those are practical questions about governing. Thank you for supporting Cops & Congress and the work that makes these questions part of the public conversation. I’m grateful to David Dickson and the CC Now team for this opportunity, and I look forward to bringing what I learn back to you. Annie DanceEditor & Publisher, Cops & Congress — Learn more about this newsletter, ethics policy, how you can help shape this work, and support it. Follow on X and Facebook. Send constructive criticism, fan mail, and tips with public documents for future stories: CopsandCongress@gmail.com ICYMI: View the Cops & Congress archive — Annie Dance is the publisher of Cops & Congress, a newsletter that analyzes what happens when crime, courts, disaster, democracy, and small-town policies collide. Views expressed here are covered by the First Amendment. Dance has a Bachelor of Arts from Manhattan University in Communication with a focus in Journalism and Government. She has been a journalist for over 20 years. Share Upgrade now or give a gift subscription
'The Simpsons' resurrects Apu after nearly a decade of silence
The Halloween-themed episodes of “The Simpsons” have always been a treat of spooky stand-alone storylines. On Sunday, the show surprised viewers with the resurrection of Apu. The beloved Indian Kwik-E-Mart
Mahjong studio opens in Blue Springs as the centuries-old Chinese game sees a surge in new players
A new Blue Springs studio, Bam Bird Social, is dedicated to teaching and playing mahjong as the game surges in popularity.
I’ve used the Pixel 11 Pro XL and iPhone 18 Pro Max, and Apple’s ecosystem isn’t enough anymore
I've used iPhones for almost two decades, and much of what made Apple's devices an easy choice has eroded.
Arsenal must play to their strengths, not entertain the neutrals
Arsenal’s attacking limitations are clear, but defensive strength can keep their title challenge on course until January. With tough away trips ahead, Arteta should embrace what his team do best while finding ways to turn control into more chances.
Meet the 2026 Power Partners in Business Products & Services
These companies help you grow your business and achieve your goals.
Some Google Home Speakers caught downloading hundreds of gigs of data
The issue might be tied to failed attempts to install a firmware update.
UW Health’s East Madison Hospital expands amid patient demand
The $140 million project expands inpatient and surgical capacity as officials say increases in patient demand continue to grow.
Names in the News: People shaping the future of Lake Area business
Sowela appoints vice chancellors Sowela Technical Community College is pleased to announce the promotion of two distinguished members of its leadership team, Allison Dering and Dr. David LaFargue, from executive […]
Walmart rolls out new bundle combining Walmart+, Sam’s Club Plus
Walmart shoppers can now get Walmart+ and Sam’s Club Plus together for $120 a year, nearly $100 less than buying both memberships separately.
LACMA, Perrotin, the new Metro and now the Brick: Todd Gray is having a banner year
Todd Gray has a solo show opening at the Brick on Oct. 18 — the cap on a banner year including a LACMA commission, a solo show at Perrotin and a public art piece for the Wilshire/La Cienega station for the D line.
Griffin William Sherry to bring folk, country, rock to The Grand
Join Maine-born singer-songwriter Griffin William Sherry and friends for an evening of powerful songwriting and live music at The Grand on Nov. 6 at 7 p.m. Experience Sherry's unique blend of folk, country, and rock and roll, rooted in his rural Maine upbringing. Get your tickets now for this unforgettable musical event.
As Hollywood implodes, is success still possible for a striving actor?
Last year 34-year-old actor Katie Folger moved from Austin into a Silver Lake casita to pursue her acting dream. Now she's performing a one-woman show called "Getting in Bed With the Pizza Man" at Elysian Theater. But will the TV pilot sell?
Envelope Insiders Live: See stars of 'Furious,' 'Love Story' and more
The creatives behind 'Furious,' 'Love Story,' 'The Only Living Pickpocket in New York' and 'Tenzing' joined us for a day of food, wine and great conversations. Take a look inside.
As Science and Technology Advance, Nurses Become More Essential to Successful Organ Transplants
Symposium of articles examines how innovations in organ donation and transplantation reinforce the vital role for critical care nurses and advanced practice nurses throughout the continuum of care for donors, candidates awaiting transplantation, recipients and their respective families.
Opinion | Dane County must stop underfunding mental health services
Natalie Eilbert: The need for mental health support is high, but Dane County’s contract model sets major provider Journey Mental Health Center up to fail.
Would Trump accept GOP midterm losses? 7 in 10 Americans doubt it.
A Post-ABC News-Ipsos poll finds broad confidence that votes will be counted accurately, but deep doubt that the president would accept the results if Republicans lost.
List of DVD release dates for Oct. 20 and beyond
Following is a partial schedule of coming movies on DVD. Release dates are subject to change: OCTOBER 20: Masters of the Universe 20: Hadestown: The Musical 20: One Night Only
The Kardashian personal chef reveals celebs' top requests
Khristianne Uy, best known as Chef K, has built a career in the celebrity-sphere cooking for major names like Justin Bieber, Salma Hayek, Ryan Seacrest and — most notably —
New coalition aims to keep Virginians covered as Medicaid rules tighten
Virginia Secretary of Health and Human Resources Marvin Figueroa on Monday announced the Virginia United Coalition, formalizing a partnership that builds on a series of roundtable meetings with him and Gov. Abigail Spanberger throughout the summer, as well as an executive order she signed.
The art of science: MU students make art inspired by biology, anthropology departments
HUNTINGTON — Some artists would get mad if someone drove over their artwork, but that wasn’t the case in Pullman Square on Friday evening.
Yankees news: Teruaki Sato will officially be posted
Sato will officially be posted this offseason; Boone returns as skipper for 2027; Wells identifies foul tips as potential cause of headaches.
Two candidates compete to succeed a New Orleans constable who served for over 20 years
The race pits the incumbent’s second-in-command, and his cousin, against a New Orleans East businessman.
Brenda Lucas: Community news for Tuesday, Oct. 20
Click for community news in the Huntington, West Virginia, and Tri-State area.
PREVIEW: Wolves face Portsmouth for the first time since 2010
Portsmouth will travel to Molineux on Tuesday evening for the first time in 17 years to face Wolves in a rescheduled Championship fixture.With a game in hand, a win for Cesar Peixoto’s side will see...
Banijay Confirms Senior Leadership Structure
The newly-minted Banijay Entertainment has set out its senior leadership team following the merger with All3Media.
Pfizer makes ‘business decision’ to end phase 2 trial of autoimmune drug as program’s future uncertain
Pfizer has called time on a phase 2 trial of its CXCR5 antibody in an autoimmune blood disorder, with the company tight-lipped on whether this marks the end of the road for the asset. The Big Pharma had been evaluating the therapy, dubbed PF-06835375, in a phase 2 study of 61 patients with primary immune thrombocytopenia (ITP) that kicked off in 2022, according to the federal trials register. However, Pfizer confirmed to Fierce on Monday that this study had been terminated “due to a business decision.” “The decision to terminate the trial was not based on any safety concerns,” a spokesperson pointed out. At time of publication, PF-06835375 remained listed on Pfizer’s website for both ITP and lupus. A phase 1 study in lupus wrapped up in 2022, according to the trials database. ITP is an autoimmune disorder characterized by a low platelet count. Novartis was at one point evaluating its B-cell-depleting antibody ianalumab—recently approved as Fabhalta to treat immunoglobulin A nephropathy—as a potential treatment ITP. But the therapy struggled to demonstrate a benefit in the clinic for this indication. When contacted by Fierce, Pfizer wouldn’t confirm whether all work on PF-06835375 has been halted, and whether the company has any other plans to explore C-X-C chemokine receptor type 5 (CXCR5) as a mechanism. CXCR5 is found in blood cancers such as diffuse large B-cell lymphoma and mantle cell lymphoma chemokine receptor. However, there is little expression in normal tissue, which has led some drug developers to explore its potential. Vincerx Pharma had at one point been planning to take an anti-CXCR5 ADC into the clinic to treat B-cell malignancies, but that ambition was scrapped due to cash constraints. Where Big Pharma is placing its bets is one of the hot topics being discussed at Fierce Biotech's high-impact event in London next month. Find out more information and register by clicking on the banner below: [ ](https://qtxasset.com/quartz/qcloud5/media/image/where_big_pharma_is_placing_its_bets.png?VersionId=B8JrRbJ.pFUSK1pJgjeWHLGm_18RdLAy)
mIRage-LS - Multimodal submicron IR imaging & spectroscopy for life science research
The mIRage-LS combines sub-500 nm O-PTIR with co-located fluorescence microscopy for advanced life science research.
GLP-1 drugs may protect kidney health in people with bipolar disorder
Mayo Clinic researchers found that GLP-1 receptor agonists, medications widely used for diabetes and weight management, were associated with a lower risk of dialysis or kidney transplantation in adults with bipolar disorder and chronic kidney disease.
Beyond the textbook: Bringing real science into the classroom
Forget baking soda volcanoes! Some high school students are getting hands-on experience with real genomic research. We talk with educators about how partnerships with working scientists are bringing cutting-edge science into the classroom.
New-to-science seahorse is one of three long-misidentified species
Scientists have identified a new-to-science seahorse species from the Indian waters, which has helped resolve the taxonomy of a group misidentified for over a century. In 1856, zoologist Johann Jakob Kaup described the thorny or spiny seahorse, Hippocampus histrix, based on samples from Japan. Since then, this seahorse has been thought to be a single, […]
Pianist Jeffrey Siegel to perform music of Brahms at Munson
Pianist Jeffrey Siegel brings The Romantic Music of Brahms to Munson in Utica on Oct. 24 as part of his Keyboard Conversations series.
STEAM dreams: Children discover science, creativity and hands-on fun as iMAGINE Festival fills Uptown Greenwood
Giant bubbles floated through the air, robots whirred to life and children became scientists, engineers and artists for a day Saturday as the iMAGINE STEAM Festival took over a large
Auburn Linebacker Xavier Atkins Dismissed From Football Program
Auburn linebacker Xavier Atkins has reportedly been dismissed from the football program following a disciplinary issue that sidelined him against Georgia. With Atkins no longer on the roster, Alex Golesh and DJ Durkin must rely on Elijah Melendez, Bryce Deas and De'Marcus Riddick against LSU.