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5 free agent cornerback options for the Detroit Lions
Five cornerback additions the Detroit Lions should consider after Terrion Arnold’s arrest.
CNBC’s Most Valuable Sports Empires 2026: Here’s how the world’s top 20 stack up
CNBC's Michael Ozanian joins 'Squawk Box' to reveal the world's most valuable sports empires.
Braille is literacy: Rice researchers are reshaping the science of reading
As schools across the country increasingly embrace evidence-based approaches to reading instruction through the science of reading, two Rice researchers are leading an effort to ensure students who learn through braille are not left out of the research shaping literacy education.
Sweden and WHO launch new long-term initiative to transform Ukraine’s health system
WHO and the Swedish International Development Cooperation Agency (Sida) have launched a new multi-year cooperation project to support the long-term recovery and transformation of Ukraine’s health system. The new project, “Ukraine’s Health System Transformation Initiative: Strengthening Health Governance, Health Financing and Service Delivery for Long-Term Recovery”, was launched at the Ukraine Recovery Conference 2026 in Gdansk, Poland on 26 June, and will run from June 2026 to 2029. Sweden will contribute approximately US$ 26 million (240 million Swedish krona) to support this project. This contribution forms part of Sweden’s broader support to Ukraine through the Team Europe approach, which brings together the European Union, its Member States, and key partners such as the European Commission’s Directorate-General for Enlargement and Eastern Neighbourhood and Enabel, and WHO as lead health agency, to support Ukraine’s recovery, reform agenda and European integration.“Ukraine’s health recovery cannot be measured only by what is rebuilt, but by whether people can count on the health system when they need it most. The scale of the task is immense, with health reconstruction and modernization needs estimated at US$ 19.4 billion over the next decade. Sweden’s US$ 26 million contribution to Ukraine’s Health System Transformation Initiative is a timely investment in the institutions, financing and services that will support Ukraine’s long-term recovery and European integration. WHO remains a trusted partner of the Government of Ukraine in advancing this process. I am deeply grateful to Sweden for its consistent support and partnership,” said Dr Hans Henri P. Kluge, WHO Regional Director for Europe. More than 4 years of war have placed unprecedented pressure on Ukraine’s health system, creating 3 interconnected challenges. The first is responding to the immediate consequences of the war and the urgent health needs of the population. The second is recovering and modernizing health services today. The third is continuing reforms and aligning the health system with European standards in the context of Ukraine’s future accession to the European Union. The war has led to large-scale population displacement, an increasing need for trauma care and rehabilitation, and shortages of health workers. High out-of-pocket payments in Ukraine make access to health services more difficult. Around 46% of total health expenditure is paid directly by individuals, placing a significant financial burden on many households and underscoring the need for reforms in health financing. Older people, persons with disabilities, women, children and veterans continue to face the greatest difficulties in accessing health services. “Ukraine is demonstrating that health system transformation can continue even during war. Ukraine is also continuing to align its health system with European norms and standards. WHO is committed to supporting Ukraine on this journey. We provide technical support, help coordinate partners’ efforts and support the institutional changes needed to strengthen the system. We are grateful to Sweden for its support. Through this partnership, we can help Ukraine build a more resilient, accessible and people-centred health system,” said Dr Jarno Habicht, WHO Representative in Ukraine. About the Health System Transformation InitiativeThe new initiative will support Ukraine through 3 interconnected areas: strengthening governance and coordination of health sector reforms through more inclusive coordination platforms and structured policy dialogue; transforming service delivery by reinforcing a primary health care-centred model that integrates family medicine, nursing and midwifery; and improving financial sustainability by supporting reforms that ensure the long-term viability of the national health system and reduce out-of-pocket payments for households. Overall, these reforms are expected to make the health system more coherent and easier to navigate, improve the quality and continuity of care, and ensure more equitable access to services, particularly for those who need them most. They will also support Ukraine’s progress towards a more modern health system aligned with European standards. “We are convinced that long-term recovery is not possible without strong, high-quality, person-centred health services that are accessible to everyone. Our partnership with WHO is designed to support deep and lasting systemic changes. Investments in human capital especially autonomous midwives, whose role for maternal, newborn and adolescent sexual and reproductive health cannot be understated, stronger governance, digital transformation and the financial sustainability of the health system are investments in Ukraine’s future. We are proud to support this process,” said Malin Perhult, the Head of the Ukraine Unit at Sida. Focus throughout implementation will be given to the most vulnerable population groups, including older people, women and children, and persons with disabilities, who have been affected by the war and face greater health-care needs. The initiative will be implemented in close cooperation with the Ministry of Health of Ukraine, the National Health Service of Ukraine, the Public Health Centre of Ukraine, regional authorities and international partners. This project will help Ukraine move towards a system where everyone can access the health care they need. It will strengthen primary care, make the health finance system more stable and predictable, and reduce the out-of-pocket costs that Ukrainians face when using health services. As a result, the Ukrainian health system will become more aligned with European standards and more sustainable in the long run.
OHSU advances massive leap in medical science with cellular therapies
Patients are benefiting from CAR-T to treat neurodegenerative diseases, cancer, lupus and other autoimmune conditions.
NFL breakout players for the 2026 season
A team of NFL players poised to have breakout campaigns in 2026.
Samsung will soon start charging to access its smart home API
Regular users could get caught by Samsung’s new $4.99 monthly charge for individual developers.
Who are Texas A&M's All-Time Quarterback recruits?
According to 247Sports, here are the top 10 ranked Texas A&M quarterbacks recruits in program history.
Accel Entertainment (ACEL) Expands Louisiana Gaming Footprint Through Truck Stop Casino Acquisition
Accel Entertainment, Inc. (NYSE:ACEL) ranks among the best sin stocks to buy for recession protection. On June 3, Accel Entertainment, Inc. (NYSE:ACEL) strengthened its Louisiana business with the acquisition of Rice Palace Truck Stop Casino in Crowley, adding a high-volume gaming venue that expands the company’s route-based gaming network in another of its strongest growth […]
New York Jets News: Geno Smith Needs Another Career Comeback
Your daily links to the New York Jets
Memorial Health Championship in full swing in Springfield
Organizers are also offering additional attractions beyond golf, including food trucks, the Scheels Fan Zone and Family Fun Day on Saturday, which features a superhero theme for children and families.
Europe’s Deadly Heat Wave: A Jolt for Climate Action, or Just for A.C.?
Heat-related deaths and disruptions to daily life are forcing politicians to reckon, in different ways, with a rapidly warming planet.
After Supreme Court’s TPS decision, more than a million immigrants face scramble to stay in US
Until Thursday, hundreds of thousands of Haitians were legally living and working in the United States, along with thousands of Syrians. Now, they’re in legal limbo.
Trump foe John Bolton is set to plead guilty. Here’s why the case didn’t fall apart
As several criminal investigations into President Donald Trump’s foes continue to flail, federal prosecutors are now ushering one of his biggest critics to a conviction.
Alito’s testy reaction to Sotomayor underscores tensions at Supreme Court
When major rulings are announced, most Supreme Court justices practice a kind of studied impassivity. Then, there’s Samuel Alito.
Big Ten women’s sports are having a moment. What is the league doing to capitalize?
In the two years since Caitlin Clark left for the WNBA, the Big Ten has worked to keep its momentum.
CNBC's Most Valuable Sports Empires 2026: Here's how the world's top 20 stack up
The world's 20 most valuable sports ownership groups are worth a combined $269 billion, according to CNBC's Most Valuable Sports Empires 2026.
Elroy Air to Become Publicly Traded Company via Business Combination with Inflection Point-led SPAC
Elroy Air, Inc., a leading U.S.-based technology developer of autonomous heavy-cargo drones for defense, rapid response and commercial logistics, and Columbu...
CORUS ENTERTAINMENT ANNOUNCES FISCAL 2026 THIRD QUARTER RESULTS
CorusEntertainmentInc. (TSX: CJR.B) announced its third quarter financial results today.
2026 NHL Mock Draft
Ahead of tonight’s NHL draft, let’s take a stab at how the first round could play out tonight. First, a moment of silence for our near miss last year – when we tried to predict that Kyle Dubas would go ‘off the board’ with a high pick on a WHL center that no one saw […]
NTT DATA | Transforming Data Into Exceptional Fan Experience
We worked with Penske Automotive Group to create a mobile application to amplify the fan experience and make the iconic Indianapolis Motor Speedway a smart venue through NTT Smart Solutions.
Williams to begin Wimbledon comeback against Joint
American superstar Serena Williams will make her highly-anticipated singles comeback at Wimbledon against Australia's Maya Joint in the first round.
How Outward Intelligence founders bootstrapped to seven-figure revenue
Three friends with résumés spanning Google, Palantir, and Harris Poll skipped venture capital and bootstrapped their startup instead.
Medical breakthroughs collide with the health system
The buzziest advances — like personalized gene therapies or AI-discovered drugs — may not deliver.
Gay Street businesses cope with Capital Line construction
The Capital Line is meant to be transformative for Downtown. But right now it's presenting challenges for businesses.
'It's business': 2027 5-star CB on choosing Texas over Texas A&M
2027 5-star CB John Meredith "loves A&M to death" but made a reported business decision in choosing the Texas Longhorns.
Commitment season looming as Ohio State staff awaits
The month of June has been a grind for Ohio State’s coaching staff. Position camps, recruiting visits, and still prioritizing their current roster, the Buckeyes have had zero time off… and that will soon change. Ryan Day and company set to be on vacation in the coming days for a well deserved break, that doesn’t […]
NFL legend reveals real reason why Antonio Brown left Steelers
NFL legend LeSean McCoy shared the real reason Antonio Brown left the Pittsburgh Steelers following the 2018 season.
Ohio Black-owned businesses, payroll has increased, bringing bigger share of economy to group
According to analysis of national census data, black-owned businesses in Ohio continue to increase payroll, and drive jobs and income in the state.
Real Madrid’s summer spending spree creates unexpected Champions League problem
Real Madrid have been one of the busiest clubs in the transfer market, but their impressive recruitment spree may have created a technical issue.Notably, Jose Mourinho has already welcomed four new si...
Hall of Fame GM Expresses Concerns About Extending Vita Vea
As a lucrative "hold-in" intensifies, Bill Polian warns that committing massive capital to an aging nose tackle could backfire for a Tampa Bay roster already in transition.
I obsess over PCs for a living. Here are the 28 best Prime Day laptop and computer deals
Prime Day is officially into Day 4, and our computing expert found some great deals on laptops and computers you can get right now.
Reasoning For Pitching Prospect's Absence From Rehab Assignment Revealed
Left-handed pitcher Ricky Tiedemann didn't make an appearance in his rehab assignment in Single-A due a separate injury than the one he's recovering from.
The Padres have problems behind the plate
Freddie Fermin’s concussion and struggles at the plate may force the Friars to seek to acquire another catcher.
Former Illinois forward Ben Humrichous signs contract with Nets
Heading to Brooklyn.
Clippers draft pick Narcisse Ngoy announces he will play at Auburn next year in unique draft-and-stash situation
World Cup 2026: USMNT stunned by Türkiye in stoppage time, losing perfect group stage run
Hollywood gets into the microdrama race as mobile-first storytelling draws stars and major studios
Mobile-first serialized storytelling is rapidly becoming one of entertainment's fastest-growing businesses.
Hollywood gets into the microdrama race as mobile-first storytelling draws stars and major studios
While much of Hollywood was consumed by the streaming wars, Issa Rae was studying a different mode of entertainment thousands of miles away: microdramas. No stranger to creating a successful online s...
Three Chicago Bears make CBS Sports’ Top 100 NFL Players of 2026 List
With the NFL on a break, get ready for list season, and CBS Sports just dropped their Top 100 Players, and three Chicago Bears made the cut.
UFC Baku early weigh ins results
Ultimate Fighting Championship (UFC) will stage its early and official weigh ins at 9 a.m. local time for this weekend’s UFC Baku mixed martial arts (MMA) event on Paramount+. Unfortunately for stateside fight fans, Baku is eight hours ahead of Eastern Standard Time, so most of us will be asleep by the time the first […]
Elliot Cadeau appears set to return to Michigan basketball roster
For the third and presumably final time this offseason, Elliot Cadeau appears to have confirmed he will stay with Michigan basketball.
Troy Melton magnificent but Tigers’ offence falters in loss
Troy Melton had a perfect game into the sixth. Unfortunately, baseball games are nine innings and runs are required.
Tempo's Marina Mabrey ties WNBA records with 53 points and 9 3-pointers in rout of Sparks
Mabrey joins A'ja Wilson and Liz Cambage in the record books.
NBA fans troll Victor Wembanyama after MVP chants in France
Victor Wembanyama is back in France after leading the San Antonio Spurs to the NBA Finals. While his team failed to win the championship, he still received a lot of love from his countrymen. The 7-foot-4 center entered a club…
Salpointe flag football QB named MaxPreps Freshman of the Year
It is the first year that MaxPreps is putting together an All-American team as the sport continues to gain popularity.
USA vs. Türkiye score, live updates: USMNT finishes group play before knockout match with Bosnia and Herzegovina
World Cup 2026: Christian Pulisic won't start for USMNT's group stage finale against Türkiye
Trump nominates Chris Klomp as HHS second-in-command
President Donald Trump on Thursday named Medicare director and former health care executive Chris Klomp to be deputy secretary of the US Department of Health and Human Services.
It's Xbox's turn (again), as console prices keep going up
Microsoft announced a price hike for the Xbox Series consoles today, the third in little over a year. Effective August 1, the Xbox Series S, which launched in 2020 for $300, will cost $500 in the U.S. The Xbox Series X, which launched in 2020 at $500, will go for $800. This follows a round of PlayStation 5 price increases from Sony this spring, and a slow-motion increase for Nintendo’s Switch 2, which will kick in in the U.S. in September. (Mind you, there were also eight video game industry price hikes in six months of 2025). The chart up top shows the sudden ascent of console prices over the past year, a sudden surge in an already unusual hardware generation. Prices had been flat for years, now “up” is the new “flat.” Game console prices used to go down across the length of a console generation, but not this time around. Microsoft’s explanation for the new price hike today: We hoped another price increase would not be necessary, and we have spent the last several months working with suppliers on options. Unfortunately, console storage and memory prices have increased by more than 2.5x and we expect another doubling by the fall of 2027. The entire consumer electronics industry is struggling with the current components crisis, but the effects are particularly hard on consoles. Unlike phones, computers, speakers, and other consumer devices, consoles are typically not sold at a profit, but instead for less than they cost to make. This is an issue well beyond game consoles. Apple announced price hikes on its computers and tablets today as well. Game File is a reader-supported publication. To receive new posts and support my work, consider becoming a free or paid subscriber. Subscribe Item 2: Brutal Bungie cuts Bungie laid off “most” of its Destiny development team and some developers who worked on Marathon, the newest game from the struggling Sony-owned studio. A WARN notice issued by Sony to Washington State, where Bungie is based, tallied cuts impacting 292 workers, effective next month. That’s strictly for Bungie/Sony jobs in Washington and wouldn’t account for any elsewhere. The video I clipped below shows the redacted list of Bungie cuts filed to Washington State officials. As you’ll see, I had to scroll for a while… In a note emailed to PlayStation workers and published online, PlayStation game studios chief Hermen Hulst offered the following explanation for these latest cuts at Bungie: This is painful news, especially for talented colleagues whose roles have been eliminated. This decision was made only after extensive discussion and careful consideration, and I want to provide some context on how we arrived here. Over the past several months, together with Bungie leadership, we reviewed the studio’s long-term direction, development priorities, resource needs, and role within our broader portfolio strategy. We explored multiple alternatives before concluding that a reduction was necessary to align the studio’s resources with its current priorities and long-term goals. In 2022, Sony bought Bungie for $3.7 billion. The studio’s marquee game, the multiplayer live service shooter Destiny 2 was losing popularity at the time. Its next game Marathon, released earlier this year, has been well-reviewed but had a slow start. Bungie is renowned for making great shooter games, and Destiny fans have mourned the wind-down of Destiny 2. They’ve also expressed bewilderment over reports that Destiny 3 is not, per Bloomberg, immediately in the cards.
Politics Chat, June 25, 2026
A newsletter about the history behind today's politics.
How the LaMelo Ball era in Charlotte came to its sudden end
Senators demand probe into reports of secret Trump-Emrati crypto deal: ‘let them say it under oath’
Priscilla Chan on science, disease prevention and the future of medicine
CNBC's Becky Quick sits down for a conversation with Dr. Priscilla Chan, co-founder of Biohub, at Aspen Ideas: Health.
Trump will present the World Cup trophy. It could be VERY awkward
The president has launched a war with nation in the tournament, and a war of words with many others.
“Vampire Diaries” stars Nina Dobrev and Paul Wesley reuniting for “You Deserve to Know” series at Hulu
The actors will star in and executive produce the upcoming show being adapted from the book of the same name.
FEMA official who claimed he teleported to Waffle House ousted from agency, sources say
A top FEMA official who had drawn scrutiny for bizarre past remarks — including claiming he teleported to a Waffle House — has been pushed out of the agency, four sources tell CNN.
New Orleans Pelicans Exercise Karlo Matkovic's Third-Year Option
The New Orleans Pelicans have exercised Karlo Matkovic's third-year option.
Digital-Only 'Grand Theft Auto VI' Is a Car Crash for Physical Media
Not all progress is progress.
ESPN believes Detroit Lions have best weapons in NFL
ESPN’s Bill Barnwell believes the Detroit Lions have better offensive weapons than any other NFL team in 2026.
College Sports Commission to continue reviewing deals by multimedia rights companies
A judge ruled that multimedia rights companies that represent university athletic departments can continue to be subject to the same rules governing millions in third party name-image-likeness payments to players that are reshaping college sports.
College Sports Commission to continue reviewing deals by multimedia rights companies
A judge ruled that multimedia rights companies that represent university athletic departments can continue to be subject to the same rules governing millions in third party name-image-likeness payments to players that are reshaping college sports.
MLB All-Star 2026: Shohei Ohtani and Ernie Clement receive automatic spots after winning Phase 1 of fan vote
Octavia Spencer’s Orit Entertainment Names Kathryn Tyus-Adair Head Of Film & Adam Wagner Head Of Television
EXCLUSIVE: Octavia Spencer’s Orit Entertainment has made two key executive hires, naming Kathryn Tyus-Adair as Head of Film and Adam Wagner as Head of Television. “Kathryn and Adam are exceptional exe...
Tennessee court temporarily blocks state health officials from sharing undocumented ill children’s information
The “state cannot go forward with the policy” until the judge makes a final decision, said the head of the Tennessee Justice Center.
Yankees vs Red Sox: Cam Schlittler vs Connelly Early
The Yankees are back in Boston, but the rivalry is not.
Two Steelers land on CBS Sports Pete Prisco’s Top-100 NFL players list
A couple of Pittsburgh’s defensive stalwarts cracked the list.
Cowboys countdown to kickoff: Top 100 iconic games
We countdown 100 days until kickoff with a series of the most iconic games in Cowboys history. Today is Day 80
Making Our Own Luck
We are cross-posting a piece that former NIH official Kris Willis wrote for Macroscience. Kris is now the President and Founder of the Woodley Park Institute, for which I’m a board member. Picking winners or hedging bets? Federal science agencies have long wrestled with the question of how to ensure their billions of dollars of grants and contracts result in maximum benefits for Americans. On the surface, it might seem that a goal-oriented, interventionist style of management would be the best policy: prioritize our most pressing problems and distribute funding accordingly.This top-down strategy creates a unique hazard, though: bad choices can send resources in the wrong direction, resulting in slow progress that impedes the delivery of tangible benefits to citizens. Moreover, if decision makers pursue an applied advance when the underlying scientific principles remain poorly understood, they risk costly failures and a loss of support for the research enterprise at large. Examples include Nixon’s 1971 War on Cancer, undertaken on the premise that a cure could be achieved in less than a decade, the drive to build an operational commercial fusion plant by the mid-1990s, and the National Plan to Address Alzheimer’s Disease, which failed to produce the effective treatments and prevention strategies promised by 2025. The contrasting laissez-faire approach is to hedge your bets. If the path to an advance is impossible to predict, then the wisest choice might be to distribute funding to as widely as possible. The main risk of this strategy is that spreading funding thinly may limit the resources available to the most promising research, resulting in the same negative outcomes as the interventionist approach: limited support for the most promising topics, slow progress, and delayed returns. In reality, at science agencies like the National Science Foundation and National Institutes of Health, program managers navigate between these two extremes, setting some funds aside to target high-priority areas and using the rest to cover the widest possible range of meritorious proposals. This middle path seems like the most rational way to proceed, but it still requires making choices. How much should be set aside for high priority topics? What should those topics be? How should we define merit? Expert opinion can provide a helpful guide, but leading experts can have remarkably different opinions about what matters and what should be prioritized. Moreover, experts and administrators alike can be risk averse, giving an edge to high-profile, well-established concepts. What’s really needed is a data-driven framework to help guide decision-making, one that doesn’t simply repackage prestige or incumbency. Recognizing breakthroughs years in advance Many breakthroughs fail to attract funding or recognition at the earliest stages of development. Katalin Karikó, for example, spent years struggling to win grants for work on mRNA that would eventually win her and Drew Weissman a Nobel Prize. Similar stories can be told about Jim Allison’s groundbreaking studies leading to the development of cancer immunotherapy, Stan Pruisner’s demonstration that prions can self-replicate without DNA, or Robin Warren and Barry Marshall’s proof that Helicobacter pylori, not stress, causes ulcers. Yet at some point, the scientific community recognizes and responds to transformative breakthroughs like these. How does that change happen? And what if science funders could identify the areas that are on the cusp of a breakthrough? Those questions led my collaborators and me to study how scientists responded to past breakthroughs. Based on patterns in that data, we developed a means of predicting future breakthroughs, using biomedicine as a proof of concept. It’s worth taking a moment to describe how our approach works. Briefly, our prediction process begins by grouping the 18 million or so peer-reviewed papers in PubMed, the authoritative database of biomedical research, into roughly 50,000 unique topics. A small subset of these topics are so widely acclaimed as breakthroughs that they have been recognized with a major prize like a Nobel or a Lasker Award. We theorized that studying the development of these outliers over time, especially before they gained acclaim, was the key to identifying future instances of them. After defining topics, we chose 21 representative breakthroughs and asked what they looked like before they won prestigious prizes. To answer that question, we re-ran our topic-mapping algorithm repeatedly, winding back the clock one year each time, stringing together the years to follow the progress of each field as it grew and advanced. We found that in each case, the years leading up to a discovery followed a pattern: a burst of papers on a new, rapidly evolving topic, many of which quickly became influential. These characteristics—the percent of papers that are new, the percentage of papers that are brought in from other topics, and the influence of each individual paper—can all be measured separately for any given topic. Together, they act as a predictive signal that is detectable an average of five years before a transformative discovery is made, and up to thirty years before the discovery receives a major prize. Scanning the current research landscape for topics that display this signal allows us to predict what work will likely produce a future breakthrough. Each year we analyzed includes four or five signals, a number that appears to have remained constant across a twenty year time frame. In their classic work on the sociology of science, Bruno Latour and Steve Woolgar established that the desire to participate in a major discovery is an important motivator for scientists as they consider whether they should take up (or abandon) a research problem. Although further work is needed, the simplest explanation for our results is that this behavior is widespread enough to detect at scale. A foundational advance, or something like it, draws the attention of scientists and causes them to change the direction of their research. They vote with their feet, staking their own reputation and careers by publishing on and citing the new idea. That upswell of interest is the foundation of our breakthrough signal. What kind of research does our model identify as a breakthrough? After building a model based on the patterns in our 21 preselected breakthroughs, we tested it by identifying all early signals of discovery from 1994 through 1997. Of the 18 signals we found in that time period, 17 can be traced forward in time to a breakthrough. Examples include super-resolution fluorescence microscopy (see the image above), the directed evolution of proteins and enzymes (Chemistry Nobel, 2018), and sequencing the human genome (National Medal of Science, 2008). The discovery of the role of leptin signaling in obesity is a particularly interesting case study. Around 1950, scientists noticed the existence of a type of lab mouse that suffered from a unique inherited form of obesity. When given the freedom to choose their own diet, these mice ate more than normal and preferred food that was high in fat. Researchers had few clues as to why the animals overate; early experiments pointed to the existence of a soluble ob factor found circulating in the bloodstream that regulated appetite, but its identity was unknown. In 1994, Jeffrey Friedman and colleagues identified and sequenced the ob gene, noting that the protein it encoded appeared to fit the profile of a circulating factor. A year later, a trio of high-profile publications demonstrated that ob was a hormone that regulated body weight and fat deposition by regulating appetite. One of these was co-authored by Friedman, who christened it leptin from the ancient Greek word for thin. Using our model, the data from 1996 make it clear this advance would become a breakthrough. Scientists had flocked to study the biology of the new hormone, generating the flurry of new papers and citations required to produce a signal. One of these demonstrated that serum leptin concentrations reflected the amount of adipose tissue in the human body, providing clinical validation of the earlier mouse studies. Before the identification of leptin, scientists were unable to point to a specific molecule that controlled appetite and adiposity, so that it was impossible to rule out non-physiological causes of obesity; its characterization fundamentally changed our concept of weight gain. In 2010, Friedman and fellow pioneer Douglas Coleman were awarded a Lasker for the discovery. Our work also identifies breakthroughs in clinical practice and behavioral and social sciences, even though these areas are less likely to draw the attention of major prize committees. One example that falls into this category is the introduction of endovascular aneurysm repair, a minimally invasive surgical procedure for the treatment of abdominal aortic aneurysm, a leading cause of death among Americans over the age of 65. Relative to the previous standard of care, it reduces in-hospital mortality by almost four-fold. In 2017, Timothy Chuter received the American College of Surgeons’ prestigious Jacobsen Innovation award for his multiple refinements to the technique. Another under-recognized breakthrough identified by our model is the development of standardized survey instruments to assess the quality of life for HIV+ patients. The antiretroviral cocktails introduced in the mid-1990s reduced AIDS mortality, but treatment came with serious side effects. The new evaluations showed that patients whose disease progressed had worse physical functioning than Americans with other chronic diseases, while those who were asymptomatic maintained a health-related quality of life on par with the overall US population. This evidence made it possible for patients and activists to argue that even in the absence of a total cure, and in spite of the side effects, alleviation of symptoms was a worthwhile priority for clinicians. My colleagues and I have failed to identify any significant recognition for the physicians and health policy experts who pioneered this advance, although in 2016, researchers called for the World Health Organization to set targets for good health-related quality of life as part of its framework to end the AIDS pandemic. From forecasting to funding How should science funders use our predictions? Any serious discussion of what we should do with this new capability needs to begin with an understanding of its limitations. We can’t (and shouldn’t) invest all of our resources in the small number of topics predicted to produce breakthroughs. Innovative new fields are born from existing ones; they rarely arise de novo. If funders don’t maintain a diverse portfolio, the breakthroughs of tomorrow will have no antecedents. Think of this as eating the seed corn, or killing the goose that lays the golden egg. There are also multiple goals of funding beyond basic scientific discovery, including translating discoveries into clinical practice, developing new technologies, supporting economic development, and training new scientists. The investments needed to accomplish these goals are likely different from those required to support emerging breakthroughs. Finally, we must be aware that we may not capture every instance of a breakthrough. The concept is fuzzy, and not every significant discovery is recognized with a major award. Further, breakthroughs are rare, meaning that our dataset is, by necessity, small. This makes formal estimates of accuracy challenging. Although our overall success rate appears to be high, any one signal may turn out to be a false positive. We found one apparent example: the development of the third generation COX-2 inhibitors, Vioxx and Celebrex, which were much celebrated in the early 2000s as effective but non-addictive pain relievers, meets all the algorithmic criteria of a breakthrough. Five years after it received FDA approval, researchers demonstrated that Vioxx was associated with serious cardiovascular complications, and the manufacturer voluntarily pulled the drug from the market. Celebrex remains available, although like other NSAIDs, it carries an FDA warning for increased cardiovascular risk. Decision makers who were overly focused on the breakthrough potential of this research might have wasted substantial resources nurturing an area that ultimately proved to be a failure—but so would those who relied on expert opinion at the time. That said, the potential benefits of funding the next mRNA vaccine or cancer immunotherapy years earlier than we might have are large. When we can’t assume the outcome of an action, it’s worth conducting an experiment. Can targeted support for areas that are poised to produce a breakthrough increase the return on scientific investment without cannibalizing future advances? With the necessary administrative infrastructure in place, conducting this experiment would be straightforward. First, identify all the breakthrough signals between 2018 and 2023, select half at random, and commit to a decade of investment. For biomedicine, a six year window should yield about 30 topics with the potential to produce a breakthrough. Providing strong support to half of these might be accomplished for $300 million a year. That’s roughly half of the recent annual budget of the NIH Common Fund or around 20% of the fiscal year 2025 budget for ARPA-H. After five years, then again at ten, compare to see which group — the one that was actively managed, or the control — produced more breakthroughs, and on what timescale. Although we used biomedicine as an example, the same experiment could just as well be run for physics, materials science, or any other discipline. Any attempt to undertake such an experiment should keep three points top of mind. First, we can predict the topic of future breakthroughs, but the people and vision for how to move the work forward are still important. In practice, this means success requires active program managers with the expertise to develop the science and the authority to do so, including by recruiting investigators. Second, we would be wise to learn from the failures of past attempts to fund transformative research. High among these are funding modestly repackaged work, confusing the genuinely novel with the merely unfamiliar, and relying too much on incumbent investigators. All of these risks can be mitigated by thoroughly and intelligently integrating high quality data into portfolio management. Finally, we need to have patience. Even with strong funding support, producing a breakthrough takes time. If supporting breakthroughs is the best way to nurture the birth of new fields, we also need to accurately describe and properly manage the other two stages, so that we invest wisely throughout the productive lifetime of ideas and divest once they reach the point of diminishing returns. We would benefit from more study of all of these phases, especially the transition from one to another. More research could answer questions like: When does a breakthrough become an established field? How do the availability of funding, the size and characteristics of the available workforce, and the accumulation of evidence that disagrees with prevailing models affect a field’s decline? Exactly how do old ideas give birth to new ones, and can we speed up the process? The more we understand about the dynamics of scientific progress, the better we can maximize the odds that our curiosity leads to results. I’d call that finding a way to make our own luck.
How open are Americans to socialism, after all?
Democratic socialists might be having their best year ever.
Trump keeps turning Republican wins into loyalty tests
President Donald Trump’s moves on housing, FISA, Iran and Washington projects are creating new headaches for Republicans trying to show voters they can govern.
Former Steeler says drafting Pat Freiermuth was a mistake
The criticism was voiced on an episode of Cam Heyward’s
Colts roster preview: Can Riley Leonard secure backup QB role?
With training camp off in the distance, we will be previewing each player on the Colts' 90-man roster. Up next is QB Riley Leonard.
Takeaways: Supreme Court hands Trump massive wins on immigration agenda
The Supreme Court’s conservative majority delivered President Donald Trump a pair of significant affirmations of his immigration policy Thursday, paving the way for the administration to effectively remove more than 1 million people from the US and keep many others from entering in the first place.
Entrepreneurs pitched business ideas to Yahoo Finance
Yahoo Finance Executive Editor Brian Sozzi is on the hunt for the next big business breakthrough. Check out the absolute best pitches and standout moments from the innovators making waves at Cannes Lions.
Climate Attribution Conference Explores Science, Law and Accountability
Speakers explored how climate attribution research is shaping lawsuits, policy and public health.
Trump’s fixation on election overhaul bill derails GOP agenda on Capitol Hill
A nasty feud over President Donald Trump’s elections overhaul push has further crippled an already-dysfunctional Congress, leaving Republicans unable to move on critical elements of their agenda.
Chris Evert shares devastating health update
It is the news that no one wanted to hear about Chris Evert. Amid the Netflix press tour and her upcoming ESPN commentary duties at Wimbledon, we learned on Wednesday that she quietly stepped away to deal with a health…
Rays' Craig Kimbrel allows 1-out, 9th-inning homer to spoil combined no-hitter against Royals
The Ole-Miss All-Transfer Team: Offense
Now that NIL and the transfer portal are in full swing, creating NCAA Free Agency, there has been enough time for us to be able to go back and look at who have been the most impactful transfer Rebs so far. There will be an 11 man offense and 11 man defense and maybe an […]
Dating Coach Urges All Men to Avoid 'Worst' Hobby for Single Guys
A professional dating coach isn't holding back on the "F" tier hobby for single men in the United States. Blaine Anderson, a former travel industry worker who built a successful dating coach business,...
Rubio’s spin on the Iran MOU sounds different from Trump and Vance
For more than a week, America’s top diplomat was conspicuously quiet about something that would have seemed very much in his wheelhouse: a nascent agreement with Iran. But now Secretary of State Marco Rubio is speaking.
Trump Keeps Undercutting Republicans’ Message, Squandering His Own Trifecta
Divisions between the president and his party on Capitol Hill have muddled Republicans’ midterm pitch to voters, and have crippled the G.O.P. at what should be the peak of its power.
Honoring the best in small business
Fifth Street Renaissance, Resource One, Cured Catering, and ChangeBridge Consulting are all honored.
Renewed Dansby Swanson makes Cubs history with 15 RBI across 3 games vs. Mets, including 11 in doubleheader
Microsoft lifts price of Xbox consoles due to soaring component costs
Microsoft said it's increasing the price of Xbox game consoles after Apple announced price hikes for MacBooks and iPads.
Gov. Shapiro on Mamdani-backed wins in NYC: Candidates doing ‘performative politics’ must learn ‘how to deliver results’
Crews on scene of business fire in southwest Cedar Rapids
The fire happened at Tegeler Wrecker & Crane in southwest Cedar Rapids.