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Walter Koenig, who played Chekov on ‘Star Trek,’ dies at 90
“Star Trek” actor Walter Koenig has died. He was 90. The New York City raised performer who played Ensign Pavel Chekov in the original version of the 1960s sci-fi drama
Referee Defends Controversial Decision After Badé Head Injury
Robert Hartmann justifies his choice to ignore a severe collision that left Loïc Badé unconscious, sparking fierce debate over official protocols versus player safety during Leverkusen's defeat.
Greenfield Community College secures grants for new healthcare programs
Greenfield Community College has secured multiple grants to expand its healthcare training programs, including a new behavioral health apprenticeship and support for nursing assistant, phlebotomy, and midwife certifications.
Texas Athletics and McCombs’ Business of Sports Institute Launch Bevo Lab for Sports AI and Analytics
University of Texas Athletics and the Business of Sports Institute (BOSI) in the McCombs School of Business, in cooperation with Longhorn Sports Properties, have launched Bevo Lab, a platform that...
Why Bexar County's DA candidates are avoiding partisan politics
DA candidates Luz Elena Chapa, Ashley Foster and Jason Wolff say party labels don’t define them. Their plans for the felony backlog and diversion show where they differ.
Mike Tomlin defends Dan Campbell’s controversial fourth-down decision
Facing fourth-and-one from their own 23-yard line with under five minutes left in a tie game, Dan Campbell and the Detroit Lions did what they do best. They stayed aggressive. Unfortunately, star running back Jahmyr Gibbs was bottled up in the backfield, and the Lions turned the ball over on downs, giving their NFC North…
Zelda 40th Anniversary Switch 2 Pro Controller restock tracker: we’re watching these retailers
🎮 Nintendo will release a Zelda 40th anniversary Switch 2 Pro Controller on October 29 💰 It costs $99.99, the same as other limited editions 📅 A restock could occur on launch day at Walmart and Best Buy 🚨 Our Zelda Switch 2 Pro Controller restock tracker @mattswider on X will send out an alert when stock appears Walmart: Zelda Pro Controller Best Buy: Zelda Pro Controller Amazon: Zelda Pro Controller Target: Zelda Pro Controller GameStop: Zelda Pro Controller Nintendo is releasing a special limited edition Nintendo Switch 2 Pro Controller to celebrate the 40th anniversary of The Legend of Zelda series. It releases on October 29, 2026, which is when we expect to see a long-awaited restock of the hard-to-find controller. 🚨 We’re tracking Zelda Switch 2 Pro Controller stock updates. If you’d like to know when more stock arrives, follow Matt Swider on X and turn on notifications. You can also become a free or paid subscriber to The Shortcut to help support our work. 🚨 The Switch 2 Pro Controller features the same striking gold and royal emerald color scheme of the Nintendo Switch 2 The Legend of Zelda 40th anniversary edition, and also includes a fun little easter egg on the back: an 8-Bit Link. 🚨 Want the Zelda 40th Anniversary Switch 2 Pro Controller? Drop your email for restock alerts before it sells out. ⤵️ Subscribe This is the same Nintendo Switch 2 Pro Controller we’re used to, aside from the intricate design, but it means you’ll have to pay more as a result. It costs $99.99 instead of the standard $89.99. However, the Pro Controller is the easiest way to play the best Switch 2 games in TV mode. If you’ve been searching for a Zelda 40th Anniversary Switch 2 Pro Controller restock, here’s everything you need to know. Zelda 40th anniversary Switch 2 Pro Controller should restock at these retailers We’ve seen retailers such as Walmart and Best Buy restock items on release day, even when pre-orders have sold out. It’s likely that the Zelda Switch 2 Pro Controller will be up for grabs on October 29, 2026, when the controller and console launches. Demand will be high, and stock could sell out fast. However, we’ll be keeping a close eye on every major retailer, including Target, Amazon, GameStop, and the Nintendo Store and will alert our followers as soon as stock goes live. Why you can trust our Zelda Switch 2 Pro Controller restock tracker We’ve already helped over 400,000 people buy a PS5 when it was in and out of stock during Covid, and we’ve helped our subscribers continue to secure hard-to-find items. The Shortcut followers were some of the first to secure the Switch 2 when it went on sale, and we’ve also helped countless others snag limited edition consoles like the PS5 30th anniversary edition. The Shortcut and Matt Swider on X offer exclusive Zelda 40th anniversary Switch 2 Pro Controller restock updates with up-to-the-second US store inventory checks at the biggest retailers. You’ll receive an instant notification on X (if set to on) as soon as new stock arrives. Up next: Call of Duty: Modern Warfare 4 review roundup: ‘a strong return to form’ Subscribe Adam Vjestica is The Shortcut’s Senior Editor. Formerly TechRadar’s Gaming Hardware Editor, Adam has also worked at Nintendo of Europe as a Content Marketing Editor, where he helped launch the Nintendo Switch. He also runs a retro gaming YouTube channel called Game on, boy! Follow him on X @ItsMrProducts.
Follow the science
By Robert Royal Surveys of young people show that many lose their faith because they believe science has refuted religion. Among many other factors, this error is a major challenge for the Church, one that does not receive nearly the…
Mid-Columbia Ballet prepares for 50th anniversary of "The Nutcracker"
RICHLAND, WA. — For 50 years, the Mid-Columbia Ballet has brought the holiday classic The Nutcracker to audiences in the Tri-Cities. This year, the organization is celebrating that milestone with 144 dancers, new costumes and months of preparation to bring the beloved production to life. The annual performance is a major undertaking for the dancers, instructors and volunteers who work behind the scenes to make the show possible. Rehearsals span 13 weeks, with dancers practicing four days a week for multiple hours at a time.This year’s production will feature new costumes for the Waltz of the Flowers, including a sequence with as many as 25 dancers on stage at once. The show also brings together performers across generations, including adults who have been part of the production for more than 20 years. For Artistic Director Debra Rogo, the preparation begins long before the curtains open.Rogo has been involved with the Mid-Columbia Ballet for 40 years and says planning for The Nutcracker takes place throughout the year. While organizing a production of this size requires significant time and effort, she says watching young dancers grow and develop a passion for ballet makes it all worthwhile. “It’s why I do this,” Rogo said. “It is overwhelming ina good way. To be able to share into their lives and watch them develop a love of this art form and the hard work … it makes me very proud.”Rogo’s decades of involvement reflect the lasting impact the production has had on the local dance community. For many performers, The Nutcracker is more than a seasonal performance. It is an opportunity to build skills, create relationships and become part of a tradition that continues year after year.While the dancers spend weeks rehearsing their routines, a large team of volunteers works behind the scenes to support the production.More than 100 volunteers are involved this year, helping make the performance possible. Their contributions reflect the range of people who come together to support the arts in the Tri-Cities.Randy Haven, a longtime volunteer, says the sense of community is one of the things that makes the experience so special.“The people that you hear volunteering, it’s incredible,” Haven said. He described seeing people from different backgrounds working together backstage, from employees at Hanford to parents raising large families.Haven says that shared commitment creates a family-like atmosphere among the people involved in the production. For Rebecca and Torrie, the Mid-Columbia Ballet has been part of their lives since childhood. Both began dancing with the organization at age seven and have since returned as teachers, helping introduce the next generation to the art form.Their connection to the ballet has continued into their adult lives, creating an opportunity to share their love of dance with younger performers.Torrie now has three daughters performing in The Nutcracker, giving her the chance to watch them experience a tradition that was also part of her own childhood.Being able to see her daughters participate in the production has made the experience especially meaningful, she said.Although audiences can see productions of The Nutcracker in major cities such as New York and Seattle, those involved with the Mid-Columbia Ballet say the local performance offers something distinctive.The community atmosphere allows audiences to experience the production while supporting local performers and the people who dedicate their time to the arts.Rebecca says experiencing a live performance alongside other people is particularly meaningful in a world where so much time is spent looking at screens.She believes live art gives people an opportunity to connect with one another through a shared experience.The ballet’s production also gives local dancers the chance to perform for their community while continuing a tradition that has been part of the Tri-Cities for five decades. When to see ‘The Nutcracker’ in RichlandThe Mid-Columbia Ballet will present its 50th-anniversary production of The Nutcracker Dec. 10 through Dec. 13 in Richland.Tickets go on sale Nov. 1. Audiences can look forward to seeing 144 dancers, new costumes and the work of more than 100 volunteers come together for the holiday production.COPYRIGHT 2026 BY APPLE VALLEY NEWS NOW. ALL RIGHTS RESERVED. THIS MATERIAL MAY NOT BE PUBLISHED, BROADCAST, REWRITTEN OR REDISTRIBUTED.
UMHB announces $2 million challenge grant for science lab facility
BELTON, Texas (FOX 44) – The University of Mary Hardin-Baylor (UMHB) has announced that a generous donor who wants to remain anonymous has offered a $2 million challenge grant to support the …
11 Marquette faculty members among top 2% of world’s most-cited scientists
According to research at Stanford University, 11 current Marquette faculty members are listed among the top 2% of cited scientists in the world.
Regal Care nursing home conditions are ‘unacceptable,’ says Mass. public health chief
Commissioner of the Massachusetts Department of Public Health Robbie Goldstein joined GBH’s Morning Edition to discuss a recent report exposing a pattern of declining care at some nursing homes in the state.
Following NASA Grant, TCU Researcher Explains Planetary Defense
Rhiannon Mayne, Oscar and Juanita Monnig Endowed Chair of Meteoritics and Planetary Science at Texas Christian University, was recently awarded a $3.6 million grant from NASA that will use West Texas’
Bon Secours Mercy Health to acquire majority stake in Surgery Partners in $5.7B deal
Bon Secours Mercy Health is acquiring a majority share in healthcare services company Surgery Partners in a take-private deal valuing the acquiree at $5.7 billion, the organizations announced Monda | The pending deal values the short-stay surgical platform at $5.7 billion, and is the latest example of large health systems' push to build out their ambulatory networks.
📈 Monday data: The bottleneck isn’t intelligence
In the AI Investment Brief today: CapEx updates and lease commitment breakdowns Anthropic co-founder Jack Clark recently said in a speech at the IMF that the singularity has begun: For many years, researchers and science fiction authors have forecast a future in which AI systems drastically increase the pace of overall scientific and technical progress, making things move so quickly that it is hard for humans to keep up. They call this the singularity. I believe that this year we have gained convincing evidence that it has now begun. This follows Anthropic’s claim that in August, 26% of its AI R&D was led by Claude, with a human supervising its work. In October, OpenAI posted 719 math manuscripts1 made by its internal model. Math and coding are two fields where a research loop can close without leaving the desk. But can the loop close in the rest of science? Subscribe The loop is real The idea is not new. Mathematician Irving John Good, who had worked with Alan Turing at Bletchley Park, argued that a machine smarter than us “could design even better machines; there would then unquestionably be an ‘intelligence explosion,’ and the intelligence of man would be left far behind.” The Gödel machine, a self-improving computer that can rewrite its own code better than its prior, was first proposed in 2003. In 2025, researchers at Sakana AI and the University of British Columbia set out to show that this was possible. Their agents iteratively improved their own code through a feedback loop, resulting in gains of 30 pp on SWE-bench and more than 15 pp on Polyglot, testing coding skills beyond Python. The idea has since been tested in other labs. A Gemini-powered agent called AlphaEvolve found a faster matrix multiplication kernel used for training Gemini, speeding up the kernel by 23% and cutting Gemini’s training time by 1%. In China, MiniMax reported that its M2.7 model worked on improving its own agent’s harness, skills, sampling and memory. Over 100 rounds of rewriting led to a 30% gain, per its internal evaluations. In each case, what was being rewritten was not the model itself but everything around it. Is it better than human work? In September this year, in what seemed like a milestone, an AI-built agent proved as good at improving other AI agents as a human-built one. It did that in what appeared to be half the steps. But the result was inconclusive: the differences between runs were greater than the difference between the AI- and human-built agent results. Nonetheless, this is increasing the chatter around recursive self-improvement (RSI) in AI. Google’s Sundar Pichai said that “you have RSI loops along with AI researchers in various aspects of model development.” Sakana AI published a paper on RSI through multi-agent collaboration, finding that after two cycles its system scored 1.2–1.6x better per output token than the base model across four research benchmarks. Ramez Naam challenges that view. He splits AI self-improvement into five overlapping types. The first four describe how autonomous the AI is; so far, only types 1 and 2 have been observed. The fifth type describes accelerating returns, and he notes that greater autonomy doesn’t guarantee a takeoff scenario. Instead, each round of self-improvement would need to deliver at least as much as the last. The results from Sakana, AlphaEvolve and MiniMax above might look like type 3 or type 4 autonomy. But in each case, the AI wasn’t updating its own weights directly, only the ancillary parts — the harness, the memory. And where Claude leads its own R&D, for now a human still supervises.
AMPLIFY awards funding to 20 arts, humanities, and social sciences projects
Emory University has awarded over $600,000 through its new AMPLIFY: Emory Faculty Impact Fund for Arts, Humanities, & Social Sciences to support publicly engaged projects that address real-world challenges.
Stuckeman School to host expert in psychological and brain sciences for talk
The Stuckeman School in Penn State’s College of Arts and Architecture will host John Gero, research professor in psychological and brain sciences at Drexel University, for a lecture at 4 p.m. on Nov. 4 in the Stuckeman Family Jury Space. Co-hosted by the Department of Architecture, the talk will also be live-streamed via Zoom.
University of Detroit Mercy lands $7.75M defense grant to grow cybersecurity, AI workforce pipeline
The funds are to help address workforce shortages in advanced technological disciplines essential to modern military operations and applicable to civilian life.
Converting PSVs for Expedition Cruising Creates Compelling Business Model
Architect and yacht designer Stefano Pastrovich has developed a novel concept that he believes can create a compelling business model and entry for bo...
NFL Monday Night Football preview: Cowboys can't afford to lose to this version of the Eagles
Knox County Deputies Announce Backing for Sheriff Polky
ROCKLAND — The Knox County Deputy Sheriff’s Association Lodge #700 announced Oct. 26 that it is endorsing incumbent Patrick Polky for Sheriff."Our lodge represents the law enforcement personnel of the
Study outlines comprehensive roadmap for AI in mental health care
Researchers from the Faculty of Social Sciences at The University of Hong Kong (HKU), in collaboration with international experts from the University of Cambridge; the University of California, Berkeley; ...
Tulane political science professors discuss Iran war, international policy
The Tulane Journal of Policy and Political Economy hosted a panel of Tulane University professors to discuss the 2026 Iran war last Thursday. Christopher Fettweis, an associate professor of political science, began the panel by discussing the Twelve-Day War that occurred in June 2025 between Iran and Israel. “The Iranians were nowhere near nuclear weapons...
Chris Jones discusses overcoming adversity after the Week 7 loss
During his postgame press conference, Kansas City Chiefs DL Chris Jones discussed the team being equipped to overcome adversity | @EdEastonJr
OU receives more than $5M for maternal health research
OU’s College of Nursing secured more than $5 million in new NIH funding for four maternal health research projects over four years.
ESSENCE Black Women in Business Luncheon Honors Tamron Hall, Anifa Mvuemba And More
ESSENCE’s 2026 Black Women in Business Luncheon at Villa Lewaro honored Ayiko Broyard, Tamron Hall, Sarah Curtis Henry and Anifa Mvuemba.
S.T.A.L.K.E.R. 2: Heart of Chornobyl version 2.1 update ‘The Zone Lookout’ now available
GSC Game World has released the version 2.1 update “The Zone Lookout” for post-apocalyptical first-person shooter S.T.A.L.K.E.R. 2: Heart of Chornobyl.
Indiana's New Small Business Program: From Policy to Opportunity
Indiana’s approach to state contracting underwent a significant transformation this summer. Following an opinion from Attorney General Todd Rokita questioning the constitutionality of race- and sex-based contracting preferences, Gov. Mike Braun suspended the state’s Supplier Diversity Program and directed the creation of a new
Inside Business 2026 Top Forty Under 40: Dr. Jamila Wynter, Riverside Health
Jamila Wynter is a gastroenterologist at Riverside Health.
Purdue and Accenture: A model for applied partnership
Artificial Intelligence is reshaping every industry. Find out how Purdue and Accenture are working together to prepare Indiana’s workforce and students in Purdue’s Mitch Daniels School of Business for an AI-powered future.
Scientists solve mystery of 1,000-mile cloud floating on Mars
Space enthusiasts and astronomers have been tracking one of the Red Planet’s most fascinating atmospheric mysteries for years: a colossal plume officially known as the Arsia Mons Elongated Cloud (AMEC). AMEC was first discovered in 2018 and quickly became one of the most elusive answers for scientists. Researchers have now resolved this mystery using the […] Read the original article here: Scientists solve mystery of 1,000-mile cloud floating on Mars
25 faculty recognized for esteemed accolades in research, academia
Rice's winners of highly prestigious and prestigious awards were recognized Oct. 21 to celebrate Rice faculty who have earned these accolades, demarcated by the Organization of the National Research Council and the Association of American Universities.
Kennesaw State researcher explores virtual reality to improve student engagement in STEM
A Kennesaw State University researcher is exploring how virtual reality can help students stay focused and engaged during science and engineering laboratory activities. Supported by a $198,486 grant from the National Science Foundation (NSF), the research aims to help learners maintain attention, improve motor skill, and enhance learning in immersive virtual laboratories. Sungchul Jung, an assistant professor of gaming in KSU's College of Computing and Software Engineering, is leading the two-year project.
Rice engineering students become first university group inside Apple’s new Advanced Manufacturing Center
Rice University materials science and nanoengineering students gained hands-on experience in AI server production and surface-mount technology during an exclusive tour of Apple’s new Advanced Manufacturing Center in Houston.
Walmart taps startup General Medicine to expand Better Care Services
Walmart is teaming up with startup General Medicine to expand its Better Care Services, turning the digital healthcare platform into a more comprehensive healthcare marketplace. | Walmart is teaming up with startup General Medicine to expand its Better Care Services, turning the digital healthcare platform into a more comprehensive healthcare marketplace.
Inside Business 2026 Top Forty Under 40: Grayson Orsini, Williams Mullen
Grayson Orsini is an attorney with Williams Mullen.
CVS Health Q3 Earnings Preview: How to Approach the Stock?
CVS' third-quarter 2026 results face mixed segment trends, with Aetna's margin recovery and digital investments offering support amid persistent 340B pressures and membership declines.
IDEA Grants Allow Sisters to Share Passion
'UConn helped me realize I can be a STEM student, but that doesn’t mean I’m not allowed to be creative and have fun hobbies. You get to be multidiscipl ...
After AI help, participants skipped tasks without chatbot more often
A study of 1,222 people found that participants who used chatbots for simple tasks were more likely to skip exercises or answer incorrectly after AI access was removed.
Inside Business 2026 Top Forty Under 40: Sam Dreyfus, ECPI University
Sam Dreyfus is the executive vice president of ECPI University.
A progress report on Aetna's efforts to bridge trust gaps with providers
Building stronger bridges between payers and providers will prove critical in addressing the biggest challenges facing healthcare: affordability and access. | Building stronger bridges between payers and providers will prove critical in addressing the biggest challenges facing healthcare: affordability and access.
Inside the economics of Maryland’s non-revenue sports
Several of the university’s most successful programs operate at a loss and must find creative ways to raise funds.
Top salaries at Endeavor Health Clinical Operations
The nine-hospital system announced plans this month to merge with Rush University System for Health.
Top salaries at Endeavor Health Clinical Operations
The nine-hospital system announced plans this month to merge with Rush University System for Health.
Soham Basanwar wins three honors in international computer science competition
Indian American Illinois university junior finished first in the senior category and U.S. national category.
Trump dangles rural health dollars to push states to change hospital laws
The Trump administration has hinged federal funding for states on whether they end or loosen powerful but controversial laws that regulate the construction of new hospitals.
Trump dangles rural health dollars to push states to change hospital laws
The Trump administration has hinged federal funding for states on whether they end or loosen powerful but controversial laws that regulate the construction of new hospitals.
Many Medicare Patients Could Lose Access to Remote Monitoring Devices
A proposed federal rule could dramatically reduce access to remote patient monitoring programs for people on Medicare. The services aim to keep patients out of the hospital by giving them devices to monitor their health at home, but critics say there isn’t enough oversight.
City Spotlight 2026
City Spotlight from the Orange County Business Journal explores Anaheim and Riverside: the projects, industries and leaders shaping each city’s economy.
Concordia University - 50 Years In
Concordia University Irvine marks 50 years: from 36 students in 1976 to 28,000+ alumni and $45 million in new, debt-free facilities. Explore the milestones.
‘The best of the best’: CSU geologist Ellen Wohl plans for retirement after illustrious career
A university distinguished professorship and the 2026 Robert E. Horton Medal for significant contributions to hydrology are just a couple of Colorado State University Geology Professor Ellen Wohl’s the achievements. Beyond them, however, she said she is simply a woman with a deep passion for science. “My parents were teachers,” Wohl said. “My dad was a...
Fabarta Unveils Major Upgrade to Its AI for Science Platform, Named Among Inaugural "Hong Kong Top Talent Ecosystem Partners" Ahead of Hong Kong FinTech Week
PR Newswire | Powered by the upgraded RSI engine, the platform unifi
Following the Science
Robert Royal: True science and faith complement each other by recognizing higher orders of reality.
How to talk politics with family: Minnesota debate coach shares tips
A University of Minnesota debate coach is sharing advice on navigating political disagreements ahead of Election Day. He explains winning the argument isn't necessarily the goal of a political debate.
How to talk politics with family: Minnesota debate coach shares tips
A University of Minnesota debate coach is sharing advice on navigating political disagreements ahead of Election Day. He explains winning the argument isn't necessarily the goal of a political debate.
A Healthy Balance Between Rigor and Mental Health
Many students of Irvington High School typically start their own nonprofits, strive to have 4.0 GPAs and more extracurriculars than can be counted on the fingers. This is typically seen as the “key” to accomplishing an acceptance to a prestigious university, creating a rigorous and competitive environment where students tend to prioritize academic excellence over...
Innovative food processing technique boosts Nebraska companies, educational outreach
Leadership and strategic visioning by Mary-Grace Danao, research associate professor in the Department of Food Science and Technology and the Department of Biological Systems Engineering, has helped position the University of Nebraska–Lincoln at the forefront of high pressure processing-focused food safety research in partnership with private industry.
UCLA Library's Data Science Center closed amid consolidation effort
UCLA Library dissolved its data consultation center and stopped offering data analysis services in August. The university consolidated the Data Science Center into UCLA Library’s research services unit as part of a broader effort to restructure the department, a UCLA Library spokesperson said in an emailed statement.
Preparing for what’s next: Nursing insights on Future Ready Healthcare
New 2026 survey findings reveal how nurses view workforce sustainability, AI adoption, and patient communication, offering practical insights into what it takes to build a future-ready healthcare organization.
Kids celebrate with big Halloween fun at University Health's Fall Fest!
Hundreds of children who were born prematurely or with special needs reunited Thursday night for University Health’s annual Halloween Fall Fest, turning a night that was only open to families into a celebration of
Novant Health hosting Hilton Head hiring event Oct. 28
Novant Health will host a healthcare hiring event Oct. 28 on Hilton Head Island for nursing, laboratory, pharmacy and other positions.
Scientists Discover How Excess RNA Can Disrupt the Energy Supply Inside Cells
Scientists at Texas A&M University discovered that excess RNA can interfere with the machinery cells use to produce energy, even without triggering certain immune defenses. The findings reveal an unex...
MTSU named among Billboard's Top Music Business Schools for 12th year in a row
Middle Tennessee State University has been named a top music business school by Billboard for the 12th year in a row.MTSU's Department of Recording Industry mad
ESMO: Roche touts ‘convincing’ phase 3 KRAS data after win over rivals
Roche has shed more light on its investigational KRAS G12C inhibitor's phase 3 victory over Amgen’s Lumakras and Bristol Myers Squibb’s Krazati. The open-label Krascendo 1 trial enrolled 338 people with previously treated KRAS G12C-mutated non-small cell lung cancer (NSCLC). Patients who had already received a KRAS G12C inhibitor or pan-KRAS/RAS inhibitor were excluded from the trial. Participants received either divarasib once daily, Lumakras once daily or Krazati twice daily. Roche announced back in July that divarasib had demonstrated statistically significant improvements in progression-free survival (PFS) and overall survival (OS), meeting the trial’s primary and key secondary endpoints. But the Swiss pharma had been holding back the detailed data until now. At the European Society for Medical Oncology (ESMO) Congress in Madrid, Roche revealed that median OS for the 167 patients who received divarasib was 17.7 months, compared to 12 months for the 171 patients who received Lumakras or Krazati. The benefit was similarly clear when it came to median PFS, which stood at 9.8 months versus 5.7 months, respectively. A total of 44% of patients receiving divarasib were alive without disease progression at one year, compared to 24% of the control group, according to Roche’s presentation. It was a similar story for the objective response rate, which came in at 58% for divarasib versus 32% for the control group, while median duration of response was 11.9 months versus 6.9 months. Stefan Frings, M.D., Ph.D., deputy chief medical officer at Roche Pharma, told Fierce that the data made for a “very comprehensive, strong package, which should be convincing to health authorities.” “It’s an important advance for patients with lung cancer,” Frings said in an interview at a Madrid hotel during the conference. “It's a second-line setting, and patients who receive divarasib benefit compared to the current first-generation KRAS G12C inhibitors by having far longer overall survival,” he continued. “They live longer. They have better progression-free survival, better response rates, and with a safety profile which is—if [anything]—even better,” he said. According to Roche, 4.8% of patients receiving divarasib discontinued treatment due to treatment-related adverse events, compared to 11.7% in the control group. Serious treatment-related adverse events were also less common with divarasib, at 7.8% versus 15.2%. Roche’s confidence in divarasib had been building even before this phase 3 success. The candidate had already shown better potency and selectivity than the incumbent KRAS G12C inhibitors Krazati and Lumakras in preclinical tests. After cross-trial comparisons suggested that the edge translated into better clinical outcomes, Roche axed a study comparing divarasib to the chemotherapy docetaxel and went toe-to-toe with Lumakras and Krazati. “We designed the drug on purpose with higher potency and better selectivity,” Frings explained. “So, based on preclinical models, we clearly knew it would be superior to the first generation.” “It’s honestly not so frequent that pharma companies go head-to-head,” he added. “But if you want to make a point, if you want to convince payers, prescribers and patients … then a head-to-head win is rather rewarding.” While Amgen and BMS reached the regulatory finish line first for KRAS G12C-mutated, locally advanced or metastatic NSCLC in 2021 and 2022, respectively, they have struggled to capitalize on their head start. Krazati brought in $55 million for BMS in the second quarter, while Lumakras delivered $111 million to Amgen. For its part, Roche is aiming for peak divarasib sales of 1 billion to 2 billion Swiss francs ($1.2 billion to $2.5 billion), according to Frings. The Big Pharma is currently recruiting patients into a phase 3 trial comparing divarasib plus Keytruda against Keytruda plus chemotherapy in previously untreated advanced or metastatic nonsquamous KRAS G12C-mutated NSCLC. Roche has previously suggested that sales in metastatic disease would account for most of the forecast. Frings was tight-lipped on the exact timeline for a regulatory filing but said the Swiss pharma is “certainly keen to get this to as many patients as possible around the world.” Roche has more RAS drugs coming up behind divarasib. The pharma has already launched phase 1 trials of a pan-RAS inhibitor called RG6505 and a KRAS G12D inhibitor dubbed RG6620 in solid tumors. Roche’s partner Chugai Pharmaceutical is also testing a pan-KRAS inhibitor called AUBE00. Roche has made a “deliberate effort” to test a range of RAS drugs, Frings said. “If you have many rare mutations and you are scrambling to find sufficient patients, a pan-RAS inhibitor makes a lot of sense,” he explained.
University of Rochester Medicine Home Healthcare holds inaugural Hospice 5K
13WHAM ABC Rochester provides local news, weather forecasts, traffic updates, health reports, notices of events and items of interest in the community, local sports and entertainment programming for Rochester and nearby towns and communities including Greece, Victor, Pittsford, Penfield, Henrietta, Webster, Irondequoit, Fairport, Chili, Gates, Rush, Wheatland, Canandaigua, Farmington, Spencerport and Hilton.
After long, strange trip, Compass CEO nears launch of psilocybin pill
Compass Pathways is on the cusp of FDA approval for a proprietary version of psilocybin — the active drug in magic mushrooms.
Health board still paying for research despite criticism over patient benefit
Betsi Cadwaladr health board was due to pay Bangor University £110,686 for two researchers.
Health board still paying for research with 'unclear' patient benefit
Betsi Cadwaladr health board was due to pay Bangor University £110,686 for two researchers.
AI in policing risks deepening discrimination, research warns
AI tools learn from biased records and may deepen discrimination against minorities without oversight, researchers say.
Democrats Bob Brooks, Paige Cognetti lead GOP incumbents in pair of key Pa. swing seats
Republicans are on pace to lose the two U.S. House seats they flipped just two years ago, according to a new Inquirer/New York Times/Siena University poll.
Unwanted endorsement: Political ad causes uproar at Jerusalem's Lev Academic Center
Those who know the highly regarded college, which since 1969 has produced religious graduates with degrees in a variety of engineering fields and nursing, were likely surprised. Thousands of drivers a...
‘Optimus Prime: Awakening’ review: Peter Cullen delivers an emotional performance | Texas A&M University-San Antonio
“Optimus Prime: Awakening” is a 12-minute short film that was screened alongside the 40th anniversary theatrical re-release of “The Transformers: The Movie.” Released in 1986 after the first two seasons of the animated series, “The Transformers: The Movie” returned to theaters in 2026 as part of Hasbro’s yearlong “Apology Tour.” The marketing campaign celebrated the...
GIS students mapping trees’ health at Indiana University Northwest
When Joe Blockland’s students at Indiana University Northwest want to call up a tree on campus, they can use an app he created for it.
Netflix’s Leadership Shake Up…Explained
(Welcome to the “Most Important Story of the Week”, my bi-weekly strategy column analyzing the most important (but often not buzziest) news story of the last two weeks. I’m the Entertainment Strategy Guy, a former streaming executive who now analyzes business strategy in the entertainment industry. Please subscribe.) Well, I had a simple article planned for this week. Called “Whoa, I Missed It!”, I’d take a gander at a few important-but-under-the-radar stories I didn’t cover while I wrote about all things “Skydance. (Formerly known as “the saga of Netflix trying to buy Warner Bros., but not Discovery, then Paramount-Skydance bought all of Warner Bros. Discovery”.) Alas, that article will have to wait. Netflix made news. Ironically, my “Whoa, I Missed It!” article would have mostly been about “content” strategy decisions, which is also what today’s article is about. But instead of the entire industry, this article will only cover Netflix’s decision to upend their film and TV content teams. Just that! So that’s the full topic of the day. I’m going to tackle the issue in the opposite direction of the way “stuff” flows: uphill. We’ll start at film, then move onto TV, and then onto the CEOs themselves, and the strategy questions that still remain. But we start with the numbers driving this. Let’s dive in. Subscribe Most Important Story of the Week - Netflix Upends Their Corporate Hierarchy I’ve got a lot of thoughts, but we’ll start with the most common response to yesterday’s article. Let’s Talk Stock Price More than one person, responding to what I published two days ago, pointed out that, well, actually, the thing driving Netflix’s actions is this: In short, stock price! Even if Netflix isn’t obsessed with their own share price—they probably are, but, for the record, my strategic advice to every CEO is to absolutely ignore stock prices, which will, ironically, probably help the stock price long-term—most everyone thinks they are. By the way, I prefer market capitalization to stock prices, because it’s a more apples-to-apples way to compare companies: But there’s an even better way to look at it, and it kinda casts some doubt on the entire push here: price-to-earnings. I have a long list of articles that I wish I had written, and chief among them is an article titled, “Am I Still a Netflix ‘Bear’?” meaning someone who thinks Netflix’s stock is overvalued. As of last summer, Netflix had solved their biggest problem—which for me (circa 2019) was the lack of free cash flow—but their stock was CRAZY overvalued. That’s this chart here: Why did Netflix’s stock price increase to a price-to-earnings ratio of 50 last summer? What financial metric changed so quickly? Nothing. Given that, historically, mature entertainment companies average 10 to 20, with 16 being the average, that increase made little sense. Netflix’s stock swoon these last eight or so months wasn’t irrational; the stock price rise last year was. So if you want a really hot Netflix take, here it is: Netflix’s stock price has been going down because the financial industry recovered its senses, not because of any strategic mistake. Yes, that would imply that cleaning house may have been a mistake. That’s why the charts yesterday are so important, because they show that Netflix did have a strategic problem (a lack of hits) and that’s what they moved to address. (One could also argue the industry drastically overrated Netflix’s growth prospects, but that’s a financial industry problem, not a Netflix strategy problem per se. Some growth estimates are just crazy. *cough* AI *cough*) Now, the last time Netflix’s stock price crashed—circa 2022—it gave them an opening. I’d argue Netflix insiders knew they needed to expand post-COVID-19 crisis, adding advertising, cracking down on password sharing, and dabbling in sports. But if they had done that when their stock price was high, it would give folks a reason to second guess their strategy. (Arguably, last year, when Netflix pursued the Warner Bros. merger, it gave the industry a chance to review their business.) Instead, after the 2022 fall, they had the opening to make strategic changes. We may see Netflix pivot again following this latest slide. For example, the “binge versus weekly” conversation is alive and well again. Same for expanding into theaters even more. And adding both linear channels and streaming bundles. And maybe more either social, user-generated, vertical, or creator content. But the first shift came with who is making the content calls. A Message from Our Sponsor Last winter Pulp Fiction was on Netflix. For those same 90 days, it was also free, with ads, on Pluto TV and the Roku Channel. That is not a glitch, and it is not rare. The title has run on 20 different US streaming services since 2019, across 80 separate windows, and for more than 600 of those days it sat on a paid subscription service and a free ad-supported one at the same time. Almost nobody can see this, because when a title leaves a service, the record that it was ever there tends to leave with it. Reelgood keeps that record, dated to the day rather than the month: 4MM+ movie, show and episode titles across 300+ services globally, with timestamped arrivals, departures and moves across SVOD, AVOD, TVOD and vMVPD. Licensing teams price against every prior window. Rights teams check what a licensee actually delivered, and when. Pick a title you think you know: data.reelgood.com/title-availability Film - Dan Lin Want to know why I don’t opine on individual film or TV executives, especially new hires? Dan Lin. As I always caution, it’s really, really, really tough to predict which executives will succeed in new roles and which won’t. The successful head of co-production/finance partner, Rideback, Lin was considered for the head of DC Studios job before taking the job as the head of Netflix. By all accounts at the time, this was a smart hire. (That’s my read of the news coverage anyways.) But now that Netflix has fired Dan Lin, we got a slew of news stories about how he was doing a terrible job. In sports media, Bryan Curtis, new Substack writer/podcaster from The Ringer, calls this the “now you tell us” story, when you only hear the bad news after a star athlete leaves a sports team. In this case, now they tell us that Dan Lin was bad with talent after he got kicked out the door. So was Dan Lin a flop? It’s actually tough to say. While film moves faster than TV, even two years isn’t really enough time to evaluate a person’s output. The new head hasn’t really taken control. As Emily Horgan noted, it takes much longer than two years to produce animated films, so yeah, it’s definitely too early to judge in that domain. As for live-action films, I just published an article by Brandon Katz called “Netflix’s Summer of Bummer”, but I’d point out Netflix had a bad summer two years ago too. Arguably, their best summer came from KPop Demon Hunters last year and Happy Gilmore 2, the latter of which I saw credited to Lin. Then, the stories came out that Dan Lin clashed with talent, both Ben Affleck and Greta Gerwig, classic “now they tell us” factoids to explain his firing. This may have been true, but also should have been expected given that he was given the mandate to bring budgets back in check, especially after Rebel Moon. So if he made folks upset, well, that’s what he was hired to do! But also, he was described as “well-liked” at his hiring! In that case, I’m a bit sympathetic to Lin, since he may have been undercut by senior leadership, as often happens. Basically, a CEO hires a subordinate to be their “bad cop” and keep budgets in check, but then when talent complains, the CEO ends up undercutting them. That’s how I think you end up with a Narnia movie as expensive as any of the other flops, along with a film executive the town no longer likes. As a result, I think that Netflix is now executing a classic “hire the opposite” move by hiring Peter Rice. This phrase comes from my experience following football and basketball coaching decisions, where teams generally hire the opposite of who they just had. If you have an offense-minded head coach, hire the defensive guy. Or in college football, if you have a strong recruiter, then you pivot to an “X’s and Os” type of guy. Or in pro basketball, if you have a very analytically minded coach, you hire the player-friendly guy. I see that here. After dropping Scott Stuber—arguably a talent-friendly executive with lax budget control—Netflix hired the business guy to keep costs in check. Now Netflix is pivoting back to Peter Rice and presumably a more talent-friendly regime. (Disney, by the way, has done this twice: hiring business guys to succeed talent-friendly Bob Iger. It didn’t work out last time.) When it comes to Peter Rice…we’ll see! Maybe he works out, but maybe he doesn’t. I’d actually say the biggest problem is that Netflix still hasn’t solved its “IP Problem”, in that they don’t own much IP, so they just have a lower hit rate. The new executive won’t solve that. (Though buying Lionsgate would help.) Share “Content” - Bela Bajaria I almost published yesterday’s article after this column, but ended up flipping the order, because it told the story so well. So if you want the data for why Netflix is looking at TV to fix their problems, it’s in that article, this graph in particular: I know I just wrote that it’s often hard to judge executives, but Bajaria ran TV for six years and film for three and a half more. That’s more than enough to judge hit rates, and Netflix needs more hits. That’s the story. Since 2023, Netflix hasn’t had as many hit shows as it used to, and many of its previous power house TV shows have ended their runs (Stranger Things most of all). Also, many shows from 2020 to 2022 probably pre-dated Bajaria’s tenure. (That said, one thing may have been outside of Bajaria’s control, which I explain below.) Let’s lump some content strategy thoughts about Netflix and TV into one place: We’re just getting started with this issue, but the rest is for paid subscribers of the Entertainment Strategy Guy, so if you’d like to find out… Why I partially blame Squid Game for Netflix’s latest troubles… What is “the football trap”... Why it might not be the TV shows or films’ fault at all… What change I don’t think Netflix will make... How Bela Bajaria evolved Netflix’s TV strategy in smart ways… Whose departure likely submarined Bajaria’s final few years… One sneaky explanation for Netflix’s content struggles... And a whole lot more... ...please subscribe! We can only keep doing this great work with your support.
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