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Is your AI delivering true business growth?
RSM explores why 97% AI satisfaction masks a transformation gap in the middle market. Learn more.
Art and science blend at Murie Ranch Art Festival
During his years as a wildlife biologist in Canada, Alaska and Wyoming, Olaus Murie generated volumes of notes and sketches of the creatures he encountered and the specimens he collected
This week in Santa Cruz County business: Mixed courtroom results for Joby Aviation; digging into summer tourism numbers
In her weekly look at Santa Cruz County business, Jessica M. Pasko relays how Joby Aviation has fared in the courtroom lately, crunches local summer tourism data and spotlights more names, numbers and dates to know.
Microsoft, Nvidia CEOs to unveil new AI laptop at San Francisco event
Microsoft will unveil on Wednesday a new laptop powered by Nvidia's chips, seeking to turn Windows into a platform for AI agents to handle tasks such as writing code without having to access the cloud, analysts said.
Wisconsin women's basketball coach sees new players bond early
Badgers coach Robin Pingeton is reassembling the team with several newcomers and says they're already showing initiative.
EXCLUSIVE: VP Vance blames Alaska LNG pipeline uncertainty South Korean ‘political dynamics’
“It’s different because you have a president who delivers on his promises,” Vance said, moments before leaving on Air Force 2.
Cook and Holmquist, the newest inductees into Nebraska Athletics Hall of Fame
Nebraska volleyball welcomes two new inductees into Husker Athletics Hall of Fame, previous head coach John Cook and former player Amber Holmquist. This pair has paved the way for Husker volleyball and women’s sports as a whole.
PTSD, Health-Related Social Needs Together Increase Cognitive Risks Significantly in Veterans
A recent study asked a question critically important to VHA clinicians: Are post-traumatic stress disorder (PTSD) and health-related social needs (HRSNs) associated with incident mild cognitive impairment, Alzheimer’s disease and Alzheimer’s disease-related dementias among U.S. veterans?
'Saved by the Bell' star Dennis Haskins' cause of death revealed
The cause of death for Dennis Haskins, an actor who played Principal Richard Belding across the 'Saved by the Bell' franchise, has been revealed. The sitcom star died Sept. 27 in Burbank.
Former Olympian asks watchdogs to investigate Reflecting Pool vandalism case
Lawyers for David Hearn, who was cleared of charges of vandalizing the pool, are asking government watchdogs to investigate the conduct of senior officials.
Detroiters ask RenCen developers for $40M in gifts. What's on the list
The list of requests for the Renaissance Center's Community Benefits deal includes nearly 100 items and runs for 18 pages.
Local leaders react with shock at President Trump's comment regarding LA
Politicians from both sides of the political spectrum took to social media to condemn the president’s statement
One Foot Down Reacts: Notre Dame’s Top Need Against Stanford
Welcome to SB Nation Reacts, a survey of fans across the NCAA. Throughout the year we ask questions of the most plugged-in Notre Dame fans and fans across the country. Sign up here to participate in the weekly emailed surveys: This week for One Foot Down Reacts, we’re asking: What do you, as a Notre […]
Leaked GameStop Memo Calls $1,399.99 Used PS5 Pro Pricing "Intentional"
GameStop is now reportedly asking $1,399.99 for a pre-owned PlayStation 5 Pro, which is $500 more than Sony's $899.99 list price for a new one. Consoles with the disc drive attached go for $1,499.99, and GameStop Pro members apparently get the base unit for $1,329.99. An internal memo shared on...
ABC and Trump's FCC battle in federal court over free speech and jurisdiction issues
A lawyer for ABC on Tuesday asked a federal judge to prevent the Trump administration from conducting an unusual, early review of its broadcast licenses, likening it to a looming execution by guillotine that was already chilling the network’s editorial decisions just weeks before the U.S. midterm elections.
What Detroit Lions fans want to know after Panthers loss
Here are the questions Detroit Lions fans are asking after their team’s rough loss to the Carolina Panthers.
Trump Journeys to Where He Is Still Popular
Usually presidents hold rallies to get voters excited about an upcoming election. Last night in Nebraska, the roles felt reversed.
Michigan basketball schedule start times, TV channels for 2026-27
Michigan Wolverines announced start times and TV channels for their entire 2026-27 schedule. Here's how and when to watch them play.
NCAA proposes summer competition for college basketball teams
The NCAA is proposing allowing summer competition between college basketball teams as a potential new revenue source.
Trump loves to bash California to rally the base. 'Let ’em take out' L.A. is just the latest
Bashing California is a reliable applause line in red states like Nebraska, Alabama, Texas and Oklahoma, where Trump has been holding rallies trying to ensure his supporters get out to vote.
What did people who went to Trump’s Nebraska rally have to say?
While the perception of Republicans seems gloomy ahead of the midterms, thousands came to see and support President Donald Trump at his rally.
Meet the GOP Boogeymen
A generational change in politics is here. Just ask Hasan Piker and Adam Mockler.
Benson HS teen faces new hearing after release to mental health treatment
A 15-year-old accused of bringing dangerous chemicals to Benson High School is expected to be back in court Tuesday, where prosecutors could ask a judge to send
Nebraska kids sent out of state when they need serious mental health care
Nebraska sends more than half of children in its child welfare and juvenile justice systems out of state for serious mental health care, according to the most recent report from the state’s Foster Care Review Office, which oversees the state’s out-of-home placements.
Halle Berry denies ex-husband’s claim that she abused their 13-year-old son: ‘I would never hurt our child’
Olivier Martinez accused his ex-wife of abuse last week, asking for sole custody of their son.
USA TODAY Sports Super 10 Alaska high school flag football rankings, Week 7
After a 19-12 victory over Dimond, South Anchorage reclaims the No. 1 spot in the Alaska Super 10 flag football rankings ahead of playoffs.
University of Nebraska Sold $21K Worth of Used Urinals From Memorial Stadium
University of Nebraska fans are famously diehard — so much so that seven Cornhusker fanatics are now the proud owners of used urinal troughs from Memorial Stadium. The stadium is set to undergo a full renovation following the 2026 football season, and some of its fixtures are up for grabs. The university has already brought […]
Drake Maye's blunt response to Bills DB disrespecting Efton Chism
Patriots quarterback Drake Maye was asked about Bills safety C.J. Gardner-Johnson's comments on Efton Chism.
Trump's remark about letting Iran 'take out' LA, San Diego draws backlash
The president made the comment Monday night during a campaign rally in Nebraska
Auburn Basketball Faces Key Early Tests
Auburn basketball's opening games will serve as an early indicator of just how good this team can be. As players become more familiar with their roles, Auburn will have the chance to build confidence and team identity while also finding ways to grow. Even though early results do not matter as much as conference play, …
“Crystal Lake” gave Jason Voorhees actor the hockey mask — but only behind the scenes (exclusive)
Callum Vinson, 12, talks about his transformation into the future masked serial killer.
Vitalize secures $31M to scale AI-powered operating system for hospital staffing and scheduling
Hospital staffing and scheduling is unglamorous, complex and tedious work, and Veeraj Shah, Vitalize CEO and co-founder, believes it's the most valuable healthcare task to tackle. | Vitalize positions its software as an "air traffic control" system for healthcare operations, helping health systems automate staffing, forecast demand, manage capacity and reduce reliance on overtime and agency labor.
Another sign of rapidly expanding political map: Pollsters can’t keep up
Increased demand for polling has strained call centers that conduct surveys, squeezed capacity and complicated the task of getting accurate reads on public opinion, according to pollsters.
How to watch the Hornets’ preseason opener on Palmetto Sports & Entertainment Network
Charlotte Hornets basketball is back Tuesday night, and Grand Strand fans can watch it.
Ask Pete Dougherty your questions about the Green Bay Packers
Pete Dougherty is taking questions as the Green Bay Packers head into a Week 5 matchup against the rival Chicago Bears.
Trump signs order extending tax-free use of red-dyed diesel
He signed the order while campaigning in Nebraska
Trump signs order extending tax-free use of red-dyed diesel
He signed the order while campaigning in Nebraska
Trump signs order extending tax-free use of red-dyed diesel
He signed the order while campaigning in Nebraska
California leaders slam Trump for saying Iran could ‘take out’ L.A. or San Diego
Officials in California condemned the president's comments as “dangerous,” after he told a Nebraska rally the war in Iran was a “small price to pay for keeping the world safe.”
Trump says Iran can 'take out' LA or San Diego during political rally
President Donald Trump faces backlash for saying Iran could 'take out' Los Angeles and San Diego as a 'small price to pay' during Nebraska rally. (Source: POOL)
Trump says Iran can 'take out' LA or San Diego during political rally
President Donald Trump faces backlash for saying Iran could 'take out' Los Angeles and San Diego as a 'small price to pay' during Nebraska rally. (Source: POOL)
The Daily Mauling: 10/6/26
Kansas Jayhawks News The LJW has a writeup on what the return of Council means for the men’s basketball team. And it’s not paywalled! The KC Star took a close look at Darryn Peterson’s first NBA experience in this weekend’s preseason game. Should I consider DP content to be KU content? He doesn’t exactly carry […]
Crowley says Black infant health is a priority; Tiffany silent
We asked David Crowley and Tom Tiffany how they would address Wisconsin’s Black infant mortality crisis if elected governor. Tiffany didn’t respond.
Nebraska kids sent out of state when they need serious mental health care
Last year, children received care in such states as Massachusetts, Alabama and Virginia that local facilities either can't or won't provide. For kids, these separations can be jarring, complicating treatment and their return home, experts say.
California governor condemns Trump's 'let 'em take Los Angeles' comments
By Steve Gorman LOS ANGELES, Oct 5 (Reuters) - California Governor Gavin Newsom has lashed out at President Donald Trump for remarks to a crowd of his supporters in Nebraska's farm belt suggesting
Trump suggests Iran could 'take out' Los Angeles and San Diego
President Donald Trump suggested Monday during a political rally in Nebraska that Iran could “take out” Los Angeles and San Diego, comments that drew condemnation.
Red snapper season opens Friday; anglers can donate carcasses for science and prizes
MOREHEAD CITY, N.C. — Recreational anglers will have three days to harvest red snapper this weekend, and North Carolina fisheries officials are asking them to c
Vance says Alaska project will proceed after Trump warns Korea
Vice President JD Vance said an Alaska natural gas project with South Korea will move forward even as Seoul said its participation remains conditional on the venture being economically viable.
Chicago Sports Fans Fall Bucket List: Must Do's in the Windy City
Learn what fall sports fan activities you must do when you visit the Windy City of Chicago from basketball to football and even baseball.
Trump takes midterms message to deep red Nebraska
President Donald Trump gave supporters a campaign-style speech in Nebraska in a continued effort to fire up the GOP base ahead of the midterms. CNN’s Jeff Zeleny reports.
Texas voters get ‘Are you white?' political texts targeting James Talarico
Texas voters received political texts asking, “Are you white?” NBC 5 traced the website targeting James Talarico to political group AMERIPAC.
Hawaiʻi Island program bridges the gap between food and health
Through a partnership with the Hawaiʻi Island Community Health Center and the Food Basket, the initiative provided 25 patients with weekly food boxes that are completely locally sourced to measure how regular access to healthy, local foods would impact their overall health.
INTERVIEW: Community Health Assessment
The Chippewa, Dunn and Eau Claire City-County Health Departments are conducting a community health assessment and are asking for your thoughts.
Key Recruiting Target Visiting Duke Basketball on Monday
The Duke Blue Devils are getting a visit from a five-star recruit in the 2028 class on Monday.
Museum of Life and Science seeks additional $2M from Durham County as costs rise
The Museum of Life and Science is asking Durham County for an additional $2 million as rising construction costs have left the museum facing a $3.5 million funding gap.
Why I Don’t Think Ride Or Die Should Have Been Cancelled (And What Company Should Save It...)
(Welcome to my weekly streaming ratings report, the single best guide to what’s popular in streaming TV and what isn’t. I’m the Entertainment Strategy Guy, a former streaming executive who now analyzes business strategy in the entertainment industry. If you were forwarded this email, please subscribe to get these insights each week.) So…I recently came across a Reddit thread, talking about films on streaming, wondering why there are no reliable sources out there for streaming ratings data. Sigh. Honestly, as annoyed as I am that so many still don’t realize that we have streaming ratings, I somewhat get it. Until now, there was such a long delay between when a show or film came to streaming and when we got its viewership data; I understand why people were confused. (But, as you know, this just changed.) Also, even back in the day, how many people knew how well films did on television? Luckily, as a reader, you’re in the know. Okay, on to this week’s issue. I want to take a look at Prime Video cancelling Ride or Die and whether I agree with that decision. Overall, we didn’t have any breakout hits (no TV shows landed over 20 million hours according to Nielsen) but we have a lot of steady performers on the streaming charts. Plus, we’ll look at where $50 million in missing box office dollars went. (Spoiler: straight-to-streaming.) All that, plus new episodes of The Secret Lives of Mormon Wives, Supergirl heads to streaming, a new YA show does well on Netflix, the viewership for the Daily Wire’s $50 million fantasy show, what TV show hit-maker can’t make streaming hits, CD sales, all the flops, bombs and misses, and a whole lot more. Let’s dive right in! (Reminder: The streaming ratings report focuses on the U.S. market and compiles data from Nielsen’s weekly top ten viewership ranks, Luminate’s Top Ten Data, JustWatch and Reelgood interest data, Samba TV household viewership, company datecdotes, Netflix hours viewed data, Google Trends, and IMDb to determine the most popular content. While most data points are current, Nielsen’s data covers the weeks of September 7th to September 13th, 2026. You can find a link to my terminology here.) Subscribe Television - Ride or Die Is a Hit…But It Got Cancelled? What The Data “Says” I hate the phrase “here’s what the data says”, even though sometimes I find myself using it. If data just told us everything, we data folks would be out of a job! Data is often messy, complicated and nuanced. When it comes to strategy, many of the best decisions can’t actually use “data”, since it’s vastly too complicated to model. Anyways, I’ve been singing the praises of Prime Video’s Ride Or Die this summer, a show that did very well for them. And yet…it got cancelled. Now, usually when a show gets cancelled, a bunch of websites say “a hit show got cancelled”... Here’s the thing, though: in this case, they’re right! The data “says” that this show was a hit. Specifically, out of 522 first seasons to make a week on the Nielsen charts since 2020, it’s the 75th biggest. On Amazon, Ride or Die is eighth out of 41 first seasons: That’s top 15th percentile all time, almost exactly, which is my definition of a “hit”! I mean, outside of Reacher, Amazon needed a hit this summer! (Admittedly, Off Campus did well for Amazon in the spring, but Ride or Die performed even better.) So what happened? Why did Amazon cancel one of their rare 2026 bright spots? Well, Deadline reported a reason—which I’ll get to—but I’d break it down into three relevant questions: What is a given streamer’s reasoning? Is that reasoning sound? Could the stated reason not be the real reason? According to Deadline, Amazon felt the show “over-indexed” in middle-aged women. (This was based on leaks from within Amazon.) The logic is this: Amazon already reaches this demographic because of unlimited two-day shipping bundled with Prime, so they don’t really need more shows like this. Now, it’s my job to ask if that’s a good reason, and I’ll be honest, in this case, I don’t think it is. Sure, this show may “over-index” in middle-aged women—I’ll just assume that’s the case here—but I think folks often oversell how important over-indexing actually is. When a show is a “hit”, it isn’t a bit bigger than its rivals; it’s usually multiples bigger. For example, Elle only made the charts for two weeks at 8.3 million hours each. So Ride or Die was 80% bigger in its first two weeks, and likely had a much stronger hold, with its terrific 13 million hours in week three. Ride or Die was nearly three times bigger than Sterling Point through three weeks too. And that means that _Elle, Sterling Point a_nd other Amazon YA shows need to not just over-index a little with younger women (assuming that’s who Amazon prefers over middle-aged women), but massively over-index. Otherwise, more people in that demo (and a bunch more besides) likely watched Ride or Die. (I’ll try to explore this concept more in a future article.) And don’t get me started on how Ride or Die did compared to a certain (very, very popular, possibly the world’s most popular) YouTuber’s reality show…which didn’t make the charts after its first week and likely cost much, much more than Ride or Die. All to say, Amazon-MGM Studios/Prime Video can tell reporters that this show didn’t reach the right audience, but that excuse feels weak to me. So this leads to the third question: could other reasons have come into play? Yes! Renewal or cancellation decisions rarely (I’m tempted to say “never”) boil down to one variable. At its simplest, it’s two things: budget versus viewership. But often factors like critical acclaim, ownership and, yes, personal opinion come into play. In this case, Amazon has a new executive running things, and this show isn’t owned by Amazon-MGM Studios (unlike Elle). And yes, it may not have indexed with the right target viewers, too. Likely all of those factors came into play.1 My guess is ownership ended up mattering most. Amazon doesn’t own Ride or Die. It’s actually produced by another major studio. Fortunately/allegedly, this show is being shopped around. I can think of one brand new CEO who should consider it for one of his two major streamers…especially if he wants to rebuild goodwill in Hollywood. His name is on this list of exec producers of Ride or Die… If David Ellison needs some goodwill—and he does—rescue this female-led show tomorrow and grab some good headlines for a day. The data justifies it. Quick Notes on TV We’re just getting started with this issue, but the rest is for paid subscribers of the Entertainment Strategy Guy, so if you’d like to find out… How The Secret Lives of Mormon Wives latest season did on Hulu, post-controversy... Whether Supergirl soared on HBO Max... Why the box office is losing money due to the streamers... The viewership for the Daily Wire’s $50 million fantasy show... Updates on The Gentlemen, Lanterns, Outer Banks, King of the Hill and more... What former hit-maker has three streaming flops in a row... Whether The Mandalorian and Grogu popped in week two... All the flops, bombs and misses... And a whole lot more... ...please subscribe! We can only keep doing this great work with your support. If you want an idea of just how much content you’d get in a full issue, check out this older issue. Coming Soon! Oh man, we’re almost caught up! We just have two more issues, then the streaming Ratings Report will be coming out just two weeks after a TV show premieres! Next issue, I’ll be looking at the first two weeks of the NFL Thursday night games on streaming, a huge new spinoff, Reacher’s Neagly on Prime Video, and the latest edition of Monster: The Lizzie Borden Story on Netflix, the return of Slow Horses on Apple and MobLand (quietly one of their biggest shows) on Paramount+, and Dancing with the Stars on both ABC and Disney+. Plus I’ll take a look at animation for adults in 2026. The week after, a ton of movies are coming to streaming: Toy Story 5 on Disney+, Backrooms on HBO Max, Jackass: Best and Last on Paramount+ and The Breadwinner on Netflix, plus a Unabomber film on Netflix and a romcom on Prime Video. Woody Harrelson and Matthew McConaughey have a show on Apple, along with a game show inspired by Willy Wonka that everyone seems to hate. Long term, some crazy (but hopefully crazy like a fox) IP news. FX ordered a new Sons of Anarchy show from Charlie Hunnam, but it’s not about the biker gang. No, it features the show’s cast playing themselves in a new “meta-thriller”. Huh. And a lot of the cast is coming back. Next, Ryan Gosling is producing a Flintstones movie about a “grown-up Bamm-Bamm Rubble”. Also, huh. This one is in “early development” so we’ll see what happens. Both projects are based on IP, but also seem to have crazy takes on the IP, which I like.
Could Hawaii Flyers Pay More To Get Seatback Screens?
Alaska's next premium MAX 10 will put built-in 4K screens only in its top two cabins.
The UNC Sports Week Ahead: October 5th-11th
It’s a quiet week for UNC sports… Until it isn’t. Following a busy weekend, most of the UNC sports in action take a break until the weekend. Then during the weekend, you’ll have a lot of options for watching the Tar Heels play. This also includes a pretty big debut. UNC Basketball Yes, the regular […]
Ana Navarro addresses Rosie O’Donnell’s potential return to “The View” (exclusive)
O’Donnell previously said that she’d return for season 30, while EW later confirmed a formal ask hadn’t gone out at the time.
How a controversial camera system is monitoring mental health patients
The Lampard Inquiry started back in September 2024 and I remember going to the first hearing in Chelmsford. Subscribe The bereaved families made placards of their loved ones, they stood outside in silence and then laid flowers to mark the moment. Now, two years on, in a process meant to last another two years, there’s been a development. Last week, we were told the chair, Baroness Lampard, pictured below, could be looking at making interim recommendations. Throughout the process, she has remarked that although this inquiry is looking at almost 2,000 people who were under the care of Essex mental health services from 2000-2023 when they died, the findings could have national implications for other trusts. ‘Records 24 hours a day in patient’s bedroom’ So why has this happened? One system that the inquiry is going to take a closer look at is a controversial monitoring system called Oxevision. It monitors some vital signs of patients remotely by using a camera placed in a room. It’s used by 40% of NHS mental health trusts. But campaigners, particularly the group Stop Oxevision, have asked for this technology to be removed from mental health wards as soon as possible. I spoke to a member, Hat Porter, today and they described to me what they thought this technology did and explained their concerns: “It records 24 hours a day and it’s located in a patient’s bedroom, which is obviously somewhere you’d usually expect to be a private place. “Our concerns are that the use of the technology has been has been kind of implemented as a substitute for proper in-person support, that it’s kind of over relied on and that there’s a lot of misunderstandings and that the presence of a camera, which has often been used without people’s consent, sometimes without even their knowledge, that that has a really big impact on privacy, dignity and human rights.” ‘Not sufficient’ I put it to them that the company behind Oxevision would dispute their claims about consent and in videos I’ve seen online from NHS trusts, they make it clear that the technology is complementary to trained staff and not a replacement. [ ](https://channel4news.substack.com/p/the-nottingham-inquiry-what-lessons) [ How the Nottingham inquiry shines a spotlight on other key mental health care failings ](https://channel4news.substack.com/p/the-nottingham-inquiry-what-lessons) Victoria Macdonald · Feb 12 [ Read full story ](https://channel4news.substack.com/p/the-nottingham-inquiry-what-lessons) A team of lawyers has been working on the inquiry and with bereaved family members who have concerns about this technology. I spoke to solicitor Priya Singh, from Hodge Jones & Allen, who made the point that questions usually asked by nurses would be missing from using devices like this. “It’s not sufficient to say, oh, the patient is moving around. Somebody must go in and say, are you okay? Are you distressed? Do you want help? Is there anything I can do? Share Channel 4 News “How are you spending your time? So I think a lot of our families cannot see the function of it when ultimately the patient should only really be observed when they’ve been prescribed to be observed, they can be observed more, but that more should really be happening face to face.” The Chair will hear evidence over the next two weeks and then a decision made after that, which could have national impact if she does decide this technology should be investigated or even removed. The Department of Health and Social Care said: “The Government is committed to ensuring that lessons are learned from the Lampard Inquiry to improve patient safety. “We are confident that the Inquiry will play an important role in identifying wider learnings for the health system following the tragic events in Essex and will contribute to improvements in patient safety.” We approached LIO Health, which runs Oxevision, for comment. Subscribe Share Channel 4 News Leave a comment
Sporting KC Weekly Schedule: Oct. 7-10, 2026
Sporting Kansas City returns home to host the Portland Timbers at 7:30 p.m. CT on Saturday at Sporting Park as the club celebrates National Hispanic Heritage Month. Tickets are available on SeatGeek, including a special Latino Heritage Night ticket pack featuring an exclusive luchador mask/hat and a Corona or Coca-Cola
Windows 11 26H2 brings a hidden performance boost — and may slash RAM usage
Windows 11 26H2 quietly brings several performance improvements, including a Low Latency Profile that makes common tasks feel faster. Some users are also reporting lower RAM usage after the update, although Microsoft has not confirmed that 26H2 itself is responsible.
WATCH LIVE: Trump campaigns with Ricketts in Nebraska, where ranchers have beef with his import plan
Supreme Court passes on 'Let's Go Brandon' student speech case
A middle school said brothers couldn't wear "Let's Go Brandon" sweatshirts to class. They asked the Supreme Court to get involved.
Column: Becerra on cruise control, Hilton offers contrived fixes for California's problems
Look, Xavier Becerra could cruise to a South Pacific island and bask on the beach until election day and Californians would still choose him as their next governor.
The 2026 Lookout List: Health and Wellness
Are you feeling centered? This is a place where we value having aligned chakras, purposeful movement, a good gym to frequent and a good dispensary to drop into (for those that partake). For our Health and Wellness category of the Lookout List, we asked you for the best spots to drop into for yoga, mindful moments, health food and more.
Yale School of Medicine On the Science of Childhood Anxiety, Say, Anxiety Disorders Are the Most Common Mental Health Challenges In Youth
Credit: Matt Bradbury October 5, 2026 - By Isabella Backman - Anxiety disorders are the most common mental health challenges in youth. Left untreated, they can disrupt the lives of both children and their families. The good news is that with intervention, most children will overcome these conditions. Across Yale School of Medicine, scientists are working to understand anxiety at every level, from common anxious behaviors to molecular biomarkers in the brain. They are using their findings to develop and disseminate new evidence-based treatments for childhood anxiety. Today, the go-to treatment for childhood anxiety disorders is cognitive behavioral therapy (CBT). This is a form of psychotherapy that teaches children skills for confronting anxious thoughts and helps them practice managing situations that cause anxiety. While it is the gold-standard treatment backed by considerable scientific evidence, up to 50% of children will not see sufficient benefit from CBT alone. Wendy Silverman, PhD, Alfred A. Messer Professor in the Child Study Center, co-directs the Anxiety and Mood Disorders Program alongside Eli Lebowitz, PhD, associate professor in the Child Study Center. One of their main interests is learning how to improve outcomes beyond CBT. “We’re developing cutting-edge, research-based knowledge that can reduce the suffering that anxiety causes children and their families,” says Silverman. Changing parent behavior YSM experts are investigating how to improve CBT outcomes for children by involving the parents. Silverman’s research has uncovered two main components of parent intervention that improve childhood anxiety: not enabling children to completely avoid the things that make them anxious and taking steps to enhance their autonomy. Parents may unintentionally reinforce their child’s anxiety by allowing them to avoid what makes them anxious. They also may unintentionally limit the children’s sense of autonomy by being overly intrusive. “One of the things that we take pride in is that we’ve focused on trying to understand what parents need to do, and to test our ideas and see if changing the parents’ behaviors is enhancing the effects of CBT,” Silverman says. “Our findings thus far suggest that they do." As much as CBT can be helpful, it can also be challenging to get one’s child to do the necessary steps for CBT to work. This is one important reason why Lebowitz created a novel intervention program for parents named Supportive Parenting for Anxious Childhood Emotions (SPACE). Existing intervention programs often teach parents to act as therapists for their child, such as training them on how to practice breathing exercises. “It makes sense, but this doesn’t work very well in practice,” says Lebowitz. “And part of the reason, I think, is that it’s not easy to get your kid to do things, especially if they’re not excited about doing it.” SPACE is unique because it focuses entirely on parent involvement and changing parental behavior—children are not involved in the sessions. For example, parents learn how to use supportive messages that convey confidence that their child can tolerate and manage distress. “It might sound like a parent saying to a child, ‘I get that this is really hard for you, but I know that you can handle it,’” Lebowitz says. The program also works with parents to identify the ways in which they are accommodating anxious behaviors. “We’ll pick one thing that parents are doing that is an accommodation and help them make a detailed plan for how they’re going to change that,” Lebowitz explains. Treating Anxiety in Children and Adolescents Much of the existing research on SPACE has focused on parents of children under age 14. Ongoing studies are now exploring its use with parents of older teens. “Both anxiety and accommodation can interfere with normative developmental shifts during the teen years, including increased autonomy and individuation from parents,” says Rebecca Etkin, PhD, associate research scientist in the Child Study Center. “In this sense, SPACE may be particularly well-suited for anxious teens and their parents. We want to see whether it is effective during this distinct developmental window.” Unfortunately, many families in need of CBT face barriers, including limited availability of services and geographic constraints. One way to improve access is digital interventions. Silverman and her team are developing an evidence-based digitized intervention program for parents that they can access directly from their computer or smart phone. “The work we’re doing will be one of the very few parent interventions that is digitized and importantly tested for effectiveness,” she says. Creating interventions for anxiety-related challenges Silverman and Lebowitz recently received a generous gift to develop and test other interventions that help parents reduce other child anxiety-related behavioral and emotional difficulties, such as restrictive eating and unexplained somatic symptoms. One of these projects in particular focuses on understanding the risks of social media and its potential benefits, including offering a sense of connection. “A lot of research has focused on the idea that social media is harmful and the less of it the better,” says Lebowitz. “But we actually see is that this is not quite right—there are negatives, but there are also positives. So, we’re trying to get a little bit more nuanced of a picture.” The team is working with teens with social anxiety and their parents over an extended period to better understand their social media habits and how their anxiety levels affect engagement with different platforms. The teens will answer questions sent to an app on their phones about mood and social media usage in an effort to capture emotional responses as they unfold. “We hope to develop interventions that can help make the best of social media while protecting against the more problematic effects,” Lebowitz says. The brain’s role in anxiety Researchers are also testing therapies to address anxiety at the neurological and molecular levels. In collaboration with Dylan Gee, PhD, professor of psychology in Yale's Faculty of Arts and Sciences, and Hilary Blumberg, MD, John and Hope Furth Professor of Psychiatric Neuroscience at Yale School of Medicine, Lebowitz and Silverman are using brain imaging to identify changes in a child’s brain before and after parents enroll in SPACE. In one study, children viewed anxiety-inducing images while undergoing magnetic resonance imaging (MRI); the researchers conducted scans with and without the children’s parents nearby. Before SPACE, children’s brains were better able to activate the regulatory circuitry needed to turn off an anxious response when their parents were nearby. But after SPACE, children could activate this circuitry even without the parent around. “As parents work on gradually reducing some of their accommodations, you can see a child get better at regulating their own fear system in the brain,” Lebowitz says. “It’s remarkable.” Research into the molecular underpinnings of anxiety can also inform new childhood anxiety treatments. In a recent study, Lebowitz, Silverman, and Flora Vaccarino, MD, Harris Professor in the Child Study Center, discovered that a protein known as fibroblast growth factor 2 (FGF2) could be protective from the toxic effects of stress. FGF2 levels in children and their parents were linked to the children’s risk of developing anxiety and depression, the study showed. The findings could help explain why some children who are exposed to early life trauma such as poverty or abuse are more prone to developing mental health disorders. And FGF2 could be a target for treatment. “This is very novel because it starts to give a clue to what is the molecular chain that connects those lived experiences to the actual psychological outcomes,” Lebowitz says. New ways to study and treat childhood anxiety Michael Crowley, PhD, associate professor in the Child Study Center, collaborates with Silverman and Lebowitz to study the role that attention plays in development and maintenance of childhood anxiety. There is a large body of research that shows that anxious children, like anxious adults, are prone to focus on threatening stimuli such as angry faces compared with neutral faces. This has led to innovative interventions that involve attention retraining. The idea is that if experts train children to look away from threatening stimuli, it may reduce their anxiety—especially children with social anxiety who are most prone to attend to threats. The researchers have just completed a clinical trial for attention retraining with 10- to 14-year-olds with social anxiety disorders and are currently analyzing the findings. Besides this innovative attention retraining research, as Crowly notes, “I like to design tasks that are engaging to kids,” Crowley says. “My goal is to assess something without the kids knowing what we are assessing.” With this goal in mind, Crowley has created a virtual game, named Boom, to study threat processing in children with anxiety disorders. The game is similar to that of hot potato—the child and three digital players take turns virtually passing a ball to each other’s gloves. At some point, the ball turns into a bomb, and as the bomb lands in each player’s glove, the outline of the glove turns yellow. The goal is to avoid having the bomb go off in your glove. What isn’t obvious is that the game is designed to measure different types of threatening stimuli, both ambiguous and direct. In the game, the direct threat occurs as the bomb is traveling towards your glove. The ambiguous threat is the yellow outlined glove as it is unknown where the bomb will travel next. While children play the game, Crowley’s team measures their brain activity using electroencephalography (EEG). The researchers have discovered that in kids with anxiety, the brain reacts more strongly to ambiguous threats than it does in their peers, but less strongly to direct threats. They believe that the initial abnormally large brain response to not knowing where the bomb is going impairs the brain's ability to properly respond when the threat is actually traveling the child’s way. “The brains of children with anxiety are unable to differentiate between threats you need to do something about and those that are not your problem.” Michael Crowley, PhD, develops innovative games for studying anxiety in children and adolescents.Credit: Matt Bradbury Based on these insights, Crowley hopes to study whether interventions like attention training could restore appropriate threat processing. Crowley’s team is also working on a test called the Balloon Risk Avoidance Task, which evaluates risk-taking and avoidance behaviors. It features a digital balloon that is full of air and about to burst. Kids have six seconds to let air out of the balloon. The more air they let out, the less risk they face that the balloon will pop. But at the same time, the balloon becomes less valuable as it deflates. “The more air you keep in the balloon, the more points you get,” Crowley explains. So far, the researchers have found that when the balloons pop unexpectedly, teens with social anxiety show distinct brain responses. Studying these responses can help psychologists understand the underlying pathways driving the various manifestations of anxiety. The genetics of anxiety When Thomas Fernandez, MD, associate professor in the Child Study Center and of psychiatry, was still in training, there was a lot of excitement about understanding the genetics associated with autism spectrum disorder. Since then, scientists have identified around 250 genes associated with autism. The genetic contribution to anxiety disorders, on the other hand, has historically received less attention. Anxiety is less heritable than autism, but the genetic contribution for anxiety disorders that emerge in childhood may be higher than for anxiety disorders overall. While scientists estimate the heritability of anxiety disorders in general to be around 30% to 50%, some studies suggest higher heritability for certain childhood-onset anxiety presentations. “I saw firsthand how researchers in the field went about finding vulnerability genes for autism,” Fernandez says. “So, we’re using a very similar playbook for childhood anxiety.” “I saw firsthand how researchers in the field went about finding vulnerability genes for autism. So, we’re using a very similar playbook for childhood anxiety.” Thomas Fernandez, MD Associate Professor In the Child Study Center and in Psychiatry Now, Fernandez and Emily Olfson, MD, PhD, assistant professor in the Child Study Center, are studying children and their parents to identify genetic changes that are present in the child but not the parents, known as “de novo mutations.” “All of us have some de novo mutations—maybe about 50 to 100 sprinkled throughout the genome,” Olfson says. “But when they occur within the coding regions of genes, they can be really disruptive.” Previous research shows that people with autism have higher rates of damaging de novo mutations than the general population. In 2022, Olfson, Lebowitz, Silverman, and Fernandez published a study on 68 children and their families that found that children with anxiety had similarly high levels of these mutations. Studying de novo mutations can help point the researchers to where they should be looking for genes associated with anxiety. “The end game is using the genes to steer us toward the right part of biology that we can then target to come up with better treatments,” Fernandez says. Building on those findings, the team is now studying more families to better understand how these de novo mutations, along with other genetic and environmental factors, shape pediatric anxiety disorders. They recently received a National Institutes of Health grant to enroll 750 new families over the next five years. Olfson is the principal investigator, with co-investigators Lebowitz, Fernandez, Silverman, and Shuangge Steven Ma, PhD, department chair and professor of biostatistics at Yale School of Public Health. Neurodevelopment, Risk Genes, and Mental Health Conditions - The Olfson Lab Joel Gelernter, MD, Foundations Fund Professor of Psychiatry, is interested in how different anxiety disorders differ genomically. “We are studying social phobia, panic disorder, and generalized anxiety disorder, working to understand why people differ in their risk to these specific anxiety disorders and evaluating various risk factors,” he says. Gelernter was recently involved in one of the largest studies to date of the genomics underlying anxiety disorder. The study included around 122,000 people with anxiety disorders and around 730,000 without. It found that some genetic differences associated with anxiety were linked to signaling that helps reduce overactivity in the nervous system. Many anxiety medications available today work by targeting this process. “It’s nice when the biology that you get out of a large genome-wide study ratifies things that we already know because that can help increase confidence in further findings from the study,” Gelernter says. Uncovering the neurobiology of psychiatric disorders John Krystal, MD, Robert L. McNeil, Jr. Professor of Translational Research and chair of the Department of Psychiatry, is interested in the neurobiology of psychiatric disorders, including post-traumatic stress disorder (PTSD), of which anxiety is a major symptom. In the late 1980s, Krystal’s team discovered that the drug yohimbine activated symptoms in patients with PTSD. “This was the first time we could link a specific biological mechanism to the symptoms of PTSD,” Krystal says. At the time, he adds, this finding was highly controversial. “A lot of people felt that PTSD was a purely psychological syndrome that didn’t have an underlying biology.” Since then, Krystal has dived deep into understanding the neurobiology of PTSD to learn how to better treat it. His team is evaluating the use of ketamine and psychedelics. These would be among the first treatments to be developed specifically for PTSD. They may also be applicable for other disorders including anxiety disorders, Krystal adds. An important gap in PTSD treatment is the absence of biological tests that inform how to best help patients manage their PTSD symptoms. A doctor doesn’t diagnose cancer based on how they feel. Rather, they use tests of the biology of the cancer to determine the best course of treatment. “And we can’t do that in any psychiatric disorder other than Alzheimer’s disease,” Krystal says. “But now we are building a foundation for this approach to the treatment of anxiety disorders for the first time.” Source: Yale School of Medicine
Asked about his previous approach to the time before …
Asked about his previous approach to the time before …
Ruth Tucker joins the Bulletin
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Voters are increasingly using AI chatbots to fact-check and compare candidates
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Trump heads to Nebraska on Monday, where his plan to import more beef has angered ranchers
President Donald Trump is campaigning in Nebraska on Monday alongside GOP Sen. Pete Ricketts | News-Talk 1380 WAOK
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Gubernatorial candidate Byron Donalds speaks to FAMU for first townhall
The FAMU community gathered at Lee Hall to ask questions and hear from Byron Donalds, republican candidate for governor.
Ethan Hawke names surprising thriller co-starring ex Uma Thurman as his breakout: ‘Changed my life’
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Asked Jalen Duren what his main emotion is: "I would …
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Trump names national intelligence director to lead a new federal AI task force
Trump is calling it the “Super Intelligence Force,” because he has tried to rebrand AI as “super intelligence.”
Trump names national intelligence director to lead a new federal AI task force
Trump is calling it the “Super Intelligence Force,” because he has tried to rebrand AI as “super intelligence.”
Trump names national intelligence director to lead a new federal AI task force
Trump is calling it the “Super Intelligence Force,” because he has tried to rebrand AI as “super intelligence.”
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Trump names national intelligence director Jay Clayton to lead a new federal AI task force
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President Donald Trump announces creation of 'Super Intelligence Force' AI task force
President Donald Trump announced the formation of what he called a "Super Intelligence Force" to "ensure that America continues to lead the World" in AI.
Trump announces leadership of AI task force
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